Researcher Profile and Settings

Researcher

• Name

  Hattori Naoko

Profile and Settings

• Name

  Hattori, Naoko

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Institute for Molecular and Cellular Regulation, Professor
• Hoshi University, 客員教授

Education

• Apr. 2000, Mar. 2005
• Apr. 1996, Mar. 2000, Tohoku University, Faculty of Agriculture

Research Experience

• Apr. 2024, 9999, Hoshi University
• Apr. 2024, 9999, Gunma University, Institute for Molecular and Cellular Regulation, Professor
• Sep. 2022, 9999
• Oct. 2022, Mar. 2024, Hoshi University
• Apr. 2022, Sep. 2022, National Cancer Center Research Institute
• Apr. 2011, Mar. 2022, National Cancer Center Research Institute, Div. of Epigenomics, Staff Scientist
• Apr. 2008, Mar. 2011, National Cancer Center Research Institute, Carcinogenesis Division, Research Resident
• Apr. 2006, Mar. 2008, The University of Tokyo, Dep. of Animal Resource Sciences, Research Associate
• Apr. 2004, Mar. 2006, The University of Tokyo, Dep. of Animal Resource Sciences, Research Fellow of JSPS

Research Activities

Research Areas

• Life sciences, Tumor biology, Epigenetics

Research Interests

• Epigenetics
• Stem cell
• Cancer

Published Papers

• Intrinsic signaling pathways modulate targeted protein degradation, Yuki Mori Yoshino Akizuki Rikuto Honda Miyu Takao Ayaka Tsuchimoto Sota Hashimoto Hiroaki Iio Masakazu Kato Ai Kaiho-Soma Yasushi Saeki Jun Hamazaki Shigeo Murata Toshikazu Ushijima Naoko Hattori Fumiaki Ohtake, 02 Jul. 2024, Nature communications, 15, 1, 5379, Scientific journal

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• DNA demethylating agents for chemoprevention of oncovirus-associated leukemogenesis., Yuta Yamamoto Tatsuro Watanabe Hiroshi Ureshino Yuki Kurahashi Yuki Fukuda-Kurahashi Kazuharu Kamachi Kazunori Kawasoe Keisuke Kidoguchi Satoshi Yamashita Naoko Hattori Toshikazu Ushijima Shinya Kimura, 05 Jun. 2024, Leukemia, 387, 7, 1613, 1616, Scientific journal

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• Sleeping Beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development., Kana Shimomura; Naoko Hattori; Naoko Iida; Yukari Muranaka; Kotomi Sato; Yuichi Shiraishi; Yasuhito Arai; Natsuko Hama; Tatsuhiro Shibata; Daichi Narushima; Mamoru Kato; Hiroyuki Takamaru; Koji Okamoto; Haruna Takeda, 16 Oct. 2023, Nature communications, 14, 1, 6514, 6514, Scientific journal

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• HSD17B4 methylation enhances glucose dependence of BT-474 breast cancer cells and increases lapatinib sensitivity, Nobuaki Arai; Naoko Hattori; Satoshi Yamashita; Yu-Yu Liu; Takahiro Ebata; Chihiro Takeuchi; Hideyuki Takeshima; Satoshi Fujii; Haruhiko Kondo; Hirofumi Mukai; Toshikazu Ushijima, Jun. 2023, Breast Cancer Research and Treatment, Scientific journal

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• DNA Methylation Analysis, Naoko Hattori; Yu-Yu Liu; Toshikazu Ushijima, Jun. 2023, Methods in Molecular Biology, 2691, 165, 183, Scientific journal

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• Mouse methylation profiles for leukocyte cell types, and estimation of leukocyte fractions in inflamed gastrointestinal DNA samples., Kazuhiro Nishiyama; Hitomi Nishinakamura; Hideyuki Takeshima; Liu Yuyu; Chihiro Takeuchi; Naoko Hattori; Haruna Takeda; Satoshi Yamashita; Mika Wakabayashi; Kotomi Sato; Kazutaka Obama; Toshikazu Ushijima, 2023, PloS one, 18, 10, e0290034, Scientific journal

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• Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation., Yoshito Yamashiro; Karina Ramirez; Kazuaki Nagayama; Naoko Hattori; Yu-Yu Liu; Shinji Matsunaga; Shuhei Tomita; Yoshiaki Kubota; Hiromi Yanagisawa, 20 Dec. 2022, Cardiovascular research, Scientific journal

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• Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL., Yuki Kurahashi; Tatsuro Watanabe; Yuta Yamamoto; Hiroshi Ureshino; Kazuharu Kamachi; Nao Yoshida-Sakai; Yuki Fukuda-Kurahashi; Satoshi Yamashita; Naoko Hattori; Hideaki Nakamura; Atsushi Kawaguchi; Toshikazu Ushijima; Eisaburo Sueoka; Shinya Kimura, 14 Dec. 2022, Blood advances, 7, 8, 1545, 1559, Scientific journal

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• A quantification method of somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy, Sho Ueda; Satoshi Yamashita; Miho Nakajima; Tadashi Kumamoto; Chitose Ogawa; Yu-Yu Liu; Harumi Yamada; Emi Kubo; Naoko Hattori; Hideyuki Takeshima; Mika Wakabayashi; Naoko Iida; Yuichi Shiraishi; Masayuki Noguchi; Yukio Sato; Toshikazu Ushijima, Aug. 2022, Proceedings of the National Academy of Sciences of the United States of America, 119, 31, e2123241119, e2123241119, Scientific journal

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• ARID1A loss-of-function induces CpG island methylator phenotype., Harumi Yamada; Hideyuki Takeshima; Ryoji Fujiki; Satoshi Yamashita; Shigeki Sekine; Takayuki Ando; Naoko Hattori; Atsushi Okabe; Takaki Yoshikawa; Kazutaka Obama; Hitoshi Katai; Atsushi Kaneda; Toshikazu Ushijima, 05 Feb. 2022, Cancer letters, 532, 215587, 215587, Scientific journal

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• Combination of a synthetic retinoid and a DNA demethylating agent induced differentiation of neuroblastoma through retinoic acid signal reprogramming., Naoko Hattori; Kiyoshi Asada; Nozomu Miyajima; Akiko Mori; Yoko Nakanishi; Kana Kimura; Mika Wakabayashi; Hideyuki Takeshima; Chika Nitani; Junichi Hara; Toshikazu Ushijima, 11 Oct. 2021, British journal of cancer, 125, 12, 1647, 1656, Scientific journal

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• Prediction of tissue origin of adenocarcinomas in the esophagogastric junction by DNA methylation., Chun-Dong Zhang; Hideyuki Takeshima; Shigeki Sekine; Satoshi Yamashita; Yu-Yu Liu; Naoko Hattori; Hiroyuki Abe; Hiroharu Yamashita; Masahide Fukuda; Yu Imamura; Tetsuo Ushiku; Hitoshi Katai; Hiroshi Makino; Masayuki Watanabe; Yasuyuki Seto; Toshikazu Ushijima, 23 Sep. 2021, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 25, 2, 336, 345, Scientific journal

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• Rapid manipulation of mitochondrial morphology in a living cell with iCMM, Takafumi Miyamoto; Hideki Uosaki; Yuhei Mizunoe; Song-Iee Han; Satoi Goto; Daisuke Yamanaka; Masato Masuda; Yosuke Yoneyama; Hideki Nakamura; Naoko Hattori; Yoshinori Takeuchi; Hiroshi Ohno; Motohiro Sekiya; Takashi Matsuzaka; Fumihiko Hakuno; Shin-Ichiro Takahashi; Naoya Yahagi; Koichi Ito; Hitoshi Shimano, Jul. 2021, Cell Reports Methods, 1, 4, 100052, 100052, Scientific journal

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• Phase I study of tamibarotene monotherapy in pediatric and young adult patients with recurrent/refractory solid tumors., Chika Nitani; Junichi Hara; Hiroshi Kawamoto; Tomoaki Taguchi; Toshimi Kimura; Kenichi Yoshimura; Akinobu Hamada; Shigehisa Kitano; Naoko Hattori; Toshikazu Ushijima; Hiromi Ono; Masako Nakamoto; Tsukiko Higuchi; Akihiro Sato, Jul. 2021, Cancer chemotherapy and pharmacology, 88, 1, 99, 107, Scientific journal

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• Silylation of deoxynucleotide analog yields an orally available drug with anti-leukemia effects., Hiroshi Ureshino; Yuki Kurahashi; Tatsuro Watanabe; Satoshi Yamashita; Kazuharu Kamachi; Yuta Yamamoto; Yuki Fukuda-Kurahashi; Nao Yoshida-Sakai; Naoko Hattori; Yoshihiro Hayashi; Atsushi Kawaguchi; Kaoru Tohyama; Seiji Okada; Hironori Harada; Toshikazu Ushijima; Shinya Kimura, 27 May 2021, Molecular cancer therapeutics, 20, 8, 1412, 1421, Scientific journal

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• SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation., Yoshimi Yasukawa; Naoko Hattori; Naoko Iida; Hideyuki Takeshima; Masahiro Maeda; Tohru Kiyono; Shigeki Sekine; Yasuyuki Seto; Toshikazu Ushijima, 25 Feb. 2021, Carcinogenesis, 42, 2, 180, 189, Scientific journal

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• Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy., Satoshi Yamashita; Naoko Hattori; Satoshi Fujii; Takeshi Yamaguchi; Masato Takahashi; Yasuo Hozumi; Takahiro Kogawa; Omar El-Omar; Yu-Yu Liu; Nobuaki Arai; Akiko Mori; Hiroko Higashimoto; Toshikazu Ushijima; Hirofumi Mukai, 23 Sep. 2020, Scientific reports, 10, 1, 15530, 15530, Scientific journal

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• Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100, Tatsuro Watanabe; Satoshi Yamashita; Hiroshi Ureshino; Kazuharu Kamachi; Yuki Kurahashi; Yuki Fukuda-Kurahashi; Nao Yoshida; Naoko Hattori; Hideaki Nakamura; Akemi Sato; Atsushi Kawaguchi; Naoko Sueoka-Aragane; Kensuke Kojima; Seiji Okada; Toshikazu Ushijima; Shinya Kimura; Eisaburo Sueoka, 13 Aug. 2020, Blood, 136, 7, 871, 884, Scientific journal

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• Correction to: Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways., Hiroshi Moro; Naoko Hattori; Yoshiaki Nakamura; Kana Kimura; Toshio Imai; Masahiro Maeda; Masakazu Yashiro; Toshikazu Ushijima, Jan. 2020, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23, 1, 116, 117, Scientific journal

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• Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways., Hiroshi Moro; Naoko Hattori; Yoshiaki Nakamura; Kana Kimura; Toshio Imai; Masahiro Maeda; Masakazu Yashiro; Toshikazu Ushijima, Jan. 2020, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23, 1, 105, 115, Scientific journal

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• Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level, Takeshima, H.; Yoda, Y.; Wakabayashi, M.; Hattori, N.; Yamashita, S.; Ushijima, T., 2020, Clinical Epigenetics, 12, 1, 142, 142, Scientific journal

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• Genetic and epigenetic profiling indicates the proximal tubule origin of renal cancers in end-stage renal disease, Ishihara, H.; Yamashita, S.; Liu, Y.-Y.; Hattori, N.; El-Omar, O.; Ikeda, T.; Fukuda, H.; Yoshida, K.; Takagi, T.; Taneda, S.; Kondo, T.; Nagashima, Y.; Tanabe, K.; Ushijima, T., 2020, Cancer Science, 111, 11, 4276, 4287, Scientific journal

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• Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3, Maeda, M.; Takeshima, H.; Iida, N.; Hattori, N.; Yamashita, S.; Moro, H.; Yasukawa, Y.; Nishiyama, K.; Hashimoto, T.; Sekine, S.; Ishii, G.; Ochiai, A.; Fukagawa, T.; Katai, H.; Sakai, Y.; Ushijima, T., 2020, Gut, 69, 2, 243, 251, Scientific journal

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• Epigenetic reprogramming underlies efficacy of DNA demethylation therapy in osteosarcomas, Asano, N.; Takeshima, H.; Yamashita, S.; Takamatsu, H.; Hattori, N.; Kubo, T.; Yoshida, A.; Kobayashi, E.; Nakayama, R.; Matsumoto, M.; Nakamura, M.; Ichikawa, H.; Kawai, A.; Kondo, T.; Ushijima, T., 2019, Scientific Reports, 9, 1, 20360, 20360, Scientific journal

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• Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model, Hattori, N.; Niwa, T.; Ishida, T.; Kobayashi, K.; Imai, T.; Mori, A.; Kimura, K.; Mori, T.; Asami, Y.; Ushijima, T., 2019, Cancer Science, 110, 1, 147, 156, Scientific journal

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• LINC00162 confers sensitivity to 5-Aza-2′-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1, Zong, L.; Hattori, N.; Yasukawa, Y.; Kimura, K.; Mori, A.; Seto, Y.; Ushijima, T., 2019, Oncogene, 38, 26, 5281, 5293, Scientific journal

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• Novel prodrugs of decitabine with greater metabolic stability and less toxicity, Hattori, N.; Sako, M.; Kimura, K.; Iida, N.; Takeshima, H.; Nakata, Y.; Kono, Y.; Ushijima, T., 2019, Clinical Epigenetics, 11, 1, 111, 111, Scientific journal

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• Three-Component Repurposed Technology for Enhanced Expression: Highly Accumulable Transcriptional Activators via Branched Tag Arrays., Kunii A; Hara Y; Takenaga M; Hattori N; Fukazawa T; Ushijima T; Yamamoto T; Sakuma T, Oct. 2018, The CRISPR journal, 1, 337, 347, Scientific journal

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• Establishment of a high-throughput detection system for DNA demethylating agents, Okochi-Takada, E.; Hattori, N.; Ito, A.; Niwa, T.; Wakabayashi, M.; Kimura, K.; Yoshida, M.; Ushijima, T., 2018, Epigenetics, 13, 2, 147, 155, Scientific journal

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• Analysis of DNA methylation in tissues exposed to inflammation, Hattori, N.; Ushijima, T., 2018, Methods in Molecular Biology, 1725, 185, 199, Scientific journal

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• Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues, Yamashita, S.; Kishino, T.; Takahashi, T.; Shimazu, T.; Charvat, H.; Kakugawa, Y.; Nakajima, T.; Lee, Y.-C.; Iida, N.; Maeda, M.; Hattori, N.; Takeshima, H.; Nagano, R.; Oda, I.; Tsugane, S.; Wu, M.-S.; Ushijima, T., 2018, Proceedings of the National Academy of Sciences of the United States of America, 115, 6, 1328, 1333, Scientific journal

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• Analysis of gene-specific DNA methylation, Hattori, N.; Ushijima, T., 2017, Handbook of Epigenetics: The New Molecular and Medical Genetics, Scientific journal

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• Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway, Nakamura, Y.; Hattori, N.; Iida, N.; Yamashita, S.; Mori, A.; Kimura, K.; Yoshino, T.; Ushijima, T., 2017, Cancer Letters, 402, 100, 109, Scientific journal

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• A novel method to quantify base substitution mutations at the 10⁻⁶ per bp level in DNA samples, Yamashita, S.; Iida, N.; Takeshima, H.; Hattori, N.; Maeda, M.; Kishino, T.; Nagano, R.; Shimazu, T.; Tsugane, S.; Ushijima, T., 2017, Cancer Letters, 403, 152, 158, Scientific journal

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• Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer, Liang Zong; Naoko Hattori; Yukie Yoda; Satoshi Yamashita; Hideyuki Takeshima; Takamasa Takahashi; Masahiro Maeda; Hitoshi Katai; Sohachi Nanjo; Takayuki Ando; Yasuyuki Seto; Toshikazu Ushijima, Apr. 2016, GASTRIC CANCER, 19, 2, 361, 369, Scientific journal

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• Molecular mechanisms of gastric carcinogenesis, Toshikazu Ushijima; Naoko Hattori; Satoshi Yamashita, 2016, Journal of Japanese Society of Gastroenterology, 113, 11, 1868, 1877, Scientific journal

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• Early-stage induction of SWI/SNF mutations during esophageal squamous cell carcinogenesis, Nakazato, H.; Takeshima, H.; Kishino, T.; Kubo, E.; Hattori, N.; Nakajima, T.; Yamashita, S.; Igaki, H.; Tachimori, Y.; Kuniyoshi, Y.; Ushijima, T., 2016, PLoS ONE, 11, 1, e0147372, Scientific journal

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• Epigenetic impact of infection on carcinogenesis: mechanisms and applications, Naoko Hattori; Toshikazu Ushijima, Jan. 2016, GENOME MEDICINE, 8, 1, 10

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• Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway, Fu-Zheng Wei; Ziyang Cao; Xi Wang; Hui Wang; Mu-Yan Cai; Tingting Li; Naoko Hattori; Donglai Wang; Yipeng Du; Boyan Song; Lin-Lin Cao; Changchun Shen; Lina Wang; Haiying Wang; Yang Yang; Dan Xie; Fan Wang; Toshikazu Ushijima; Ying Zhao; Wei-Guo Zhu, Dec. 2015, AUTOPHAGY, 11, 12, 2309, 2322, Scientific journal

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• Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy, Hideyuki Takeshima; Mika Wakabayashi; Naoko Hattori; Satoshi Yamashita; Toshikazu Ushijima, Feb. 2015, CARCINOGENESIS, 36, 2, 192, 201, Scientific journal

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• Compendium of aberrant DNA methylation and histone modifications in cancer, Naoko Hattori; Toshikazu Ushijima, Dec. 2014, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 455, 1-2, 3, 9

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• Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis, Zhaojun Liu; Jun Zhang; Yanhong Gao; Lirong Pei; Jing Zhou; Liankun Gu; Lianhai Zhang; Budong Zhu; Naoko Hattori; Jiafu Ji; Yasuhito Yuasa; Wooho Kim; Toshikazu Ushijima; Huidong Shi; Dajun Deng, Sep. 2014, CLINICAL CANCER RESEARCH, 20, 17, 4598, 4612, Scientific journal

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• ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis, E. Okochi-Takada; N. Hattori; T. Tsukamoto; K. Miyamoto; T. Ando; S. Ito; Y. Yamamura; M. Wakabayashi; Y. Nobeyama; T. Ushijima, Apr. 2014, ONCOGENE, 33, 17, 2273, 2278, Scientific journal

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• Estimation of the fraction of cancer cells in a tumor DNA sample using DNA methylation, Takamasa Takahashi; Yasunori Matsuda; Satoshi Yamashita; Naoko Hattori; Ryoji Kushima; Yi-Chia Lee; Hiroyasu Igaki; Yuji Tachimori; Masato Nagino; Toshikazu Ushijima, 02 Dec. 2013, PLoS ONE, 8, 12, e82302, Scientific journal

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• Visualization of multivalent histone modification in a single cell reveals highly concerted epigenetic changes on differentiation of embryonic stem cells, Naoko Hattori; Tohru Niwa; Kana Kimura; Kristian Helin; Toshikazu Ushijima, Aug. 2013, Nucleic Acids Research, 41, 15, 7231, 7239, Scientific journal

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• Molecular Pathways: Involvement of Helicobacter pylori-Triggered Inflammation in the Formation of an Epigenetic Field Defect, and Its Usefulness as Cancer Risk and Exposure Markers, Toshikazu Ushijima; Naoko Hattori, Feb. 2012, CLINICAL CANCER RESEARCH, 18, 4, 923, 929, Scientific journal

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• Non-CpG Methylation Occurs in the Regulatory Region of the Sry Gene, Koichiro Nishino; Naoko Hattori; Shun Sato; Yoshikazu Arai; Satoshi Tanaka; Andras Nagy; Kunio Shiota, Oct. 2011, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 57, 5, 586, 593, Scientific journal

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• Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas, Naoko Hattori; Eriko Okochi-Takada; Mizuho Kikuyama; Mika Wakabayashi; Satoshi Yamashita; Toshikazu Ushijima, Jul. 2011, CANCER SCIENCE, 102, 7, 1337, 1343, Scientific journal

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• Analysis of gene-specific dna methylation, Naoko Hattori; Toshikazu Ushijima, 2011, Handbook of Epigenetics, 125, 134, In book

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• Genome-wide DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) residing in mouse pluripotent stem cells, Shinya Sato; Shintaro Yagi; Yoshikazu Arai; Keiji Hirabayashi; Naoko Hattori; Misa Iwatani; Keisuke Okita; Jun Ohgane; Satoshi Tanaka; Teruhiko Wakayama; Shinya Yamanaka; Kunio Shiota, Jun. 2010, GENES TO CELLS, 15, 6, 607, 618, Scientific journal

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• Resistance to 5-aza-2 '-deoxycytidine in Genic Regions Compared to Non-genic Repetitive Sequences, Hui Wen Lim; Misa Iwatani; Naoko Hattori; Satoshi Tanaka; Shintaro Yagi; Kunio Shiota, Feb. 2010, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 56, 1, 86, 93, Scientific journal

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• DNA methylation profile of tissue-dependent and differentially methylated regions (T-DMRs) in mouse promoter regions demonstrating tissue-specific gene expression, Shintaro Yagi; Keiji Hirabayashi; Shinya Sato; Wei Li; Yoko Takahashi; Tsutomu Hirakawa; Guoying Wu; Naoko Hattori; Naka Hattori; Jun Ohgane; Satoshi Tanaka; X. Shirley Liu; Kunio Shiota, Dec. 2008, GENOME RESEARCH, 18, 12, 1969, 1978, Scientific journal

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• Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation, Hiromi Asada; Yoshiaki Yamagata; Toshiaki Taketani; Aki Matsuoka; Hiroshi Tamura; Naoko Hattori; Jun Ohgane; Naka Hattori; Kunio Shiota; Norihiro Sugino, Sep. 2008, MOLECULAR HUMAN REPRODUCTION, 14, 9, 539, 545, Scientific journal

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• DNA hypomethylation circuit of the mouse oocyte-specific histone H1foo gene in female germ cell lineage, Chiaki Maeda; Shun Sato; Naoko Hattori; Satoshi Tanaka; Shintaro Yagi; Kunio Shiota, May 2008, BIOLOGY OF REPRODUCTION, 78, 5, 816, 821, Scientific journal

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• Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells, Naoko Hattori; Yuko Imao; Koichiro Nishino; Naka Hattori; Jun Ohgane; Shintaro Yagi; Satoshi Tanaka; Kunio Shiota, Mar. 2007, GENES TO CELLS, 12, 3, 387, 396, Scientific journal

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• Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development, YG Ko; K Nishino; N Hattori; Y Arai; S Tanaka; K Shiota, Mar. 2005, JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 10, 9627, 9634, Scientific journal

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• Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells, N Hattori; T Abe; N Hattori; M Suzuki; T Matsuyama; S Yoshida; E Li; K Shiota, Sep. 2004, GENOME RESEARCH, 14, 9, 1733, 1740, Scientific journal

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• DNA methylation-mediated control of Sry gene expression in mouse gonadal development, K Nishino; N Hattori; S Tanaka; K Shiota, May 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 21, 22306, 22313, Scientific journal

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• Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells, N Hattori; K Nishino; YG Ko; N Hattori; J Ohgane; S Tanaka; K Shiota, Apr. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 17, 17063, 17069, Scientific journal

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• [TWO CASES OF α-GAL SYNDROME CAUSED BY INGESTION OF WILD BOAR MEAT]., Hattori Naoko;Matsumoto Mai;Chinuki Yuko;Takenaka Motoi;Tomimura Saori;Tsukazaki Naoko;Murota Hiroyuki, Arerugi = [Allergy], 73, 8

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MISC

• 【胃癌の全て】胃癌の発生に関わる最新の知見, 牛島 俊和; 服部 奈緒子; 山田 晴美, Sep. 2021, 78, 10, 1139, 1146
• 【エピゲノムで新たな解明が進む「先天性疾患」】(第5章)エピゲノム治療・創薬 DNAメチル化阻害剤, 服部 奈緒子; 牛島 俊和, Apr. 2021, 36, 196, 203
• 【肉腫-基礎・臨床の最新知見-】肉腫の発生メカニズムと基礎研究 肉腫の研究最前線 エピジェネティクス, 服部 奈緒子; 牛島 俊和, Oct. 2020, 78, 増刊5 肉腫, 95, 102
• 【エピジェネティクスと疾患】治療への展開 DNA脱メチル化剤および変異型IDH阻害薬の臨床導入と新規開発の現状, 服部 奈緒子; 牛島 俊和, Jan. 2020, 272, 1, 106, 114
• 【エピジェネティック作用薬:現状と将来】DNA脱メチル化剤の作用機序、臨床導入および新規開発の状況, 服部 奈緒子; 牛島 俊和, Sep. 2018, 266, 11, 823, 829
• 【肝胆膵疾患のエピジェネティクスを学ぶ】エピジェネティクスの基礎 後天的な遺伝子発現制御機構, 牛島 俊和; 服部 奈緒子, May 2018, 76, 5, 851, 858
• DNA脱メチル化剤は胃癌に対して化学療法の感受性を改善する(DNA demethylating agents enhance sensitivity of gastric cancer cell to cytotoxic drugs), 茂呂 浩史; 服部 奈緒子; 中村 能章; 前田 将宏; 八代 正和; 牛島 俊和, Mar. 2018, 日本胃癌学会総会記事, 90回, 553, 553
• DNA脱メチル化剤は胃癌におけるイリノテカンの感受性を改善する, 茂呂 浩史; 服部 奈緒子; 中村 能章; 八代 正和; 牛島 俊和, Sep. 2017, 日本癌学会総会記事, 76回, P, 1163
• State of the art H.pylori感染と胃癌 どこまで分かったか?, 牛島 俊和; 茂呂 浩史; 前田 将宏; 服部 奈緒子, Jun. 2017, 9, 2, 106, 116
• 【クリニカルエピゲノミクス】がん診断への応用 エピゲノムを用いたがんの予後診断, 服部 奈緒子; 牛島 俊和, Nov. 2015, 255, 6, 629, 635
• 【遺伝性消化器癌とその対策】遺伝性癌発症のメカニズム, 牛島 俊和; 服部 奈緒子, Jun. 2014, 22, 3, 208, 212
• 【エピジェネティクスと病気】(第1章)エピジェネティクスの基礎 国際ヒトエピゲノムコンソーシアム, 牛島 俊和; 服部 奈緒子; 波羅 仁, Aug. 2013, 25, 55, 61
• 【血液疾患におけるエピゲノム異常と治療】がんエピゲノムと新規診断法開発と創薬への活用, 牛島 俊和; 服部 奈緒子; 竹島 秀幸, Mar. 2013, 66, 3, 265, 273
• 【エピジェネティクス:健康を理解する遺伝学の新しい視点】がんのエピジェネティクス, 服部 奈緒子; 牛島 俊和, Mar. 2012, 15, 3, 193, 197
• 【エピジェネティクスと疾患 基礎メカニズムと解析手法の最新知見からがん・神経・代謝・アレルギー疾患などへの応用まで】がんとエピジェネティクス エピジェネティック異常の誘発要因と機構, 牛島 俊和; 竹島 秀幸; 服部 奈緒子, Sep. 2010, 28, 15, 2457, 2463
• 【生き物を形作るしくみ エピジェネティクス】発がんとエピジェネティクス 新たにわかったがんの原因とその治療の可能性, 服部 奈緒子; 牛島 俊和, Sep. 2009, 5, 3, 22, 27
• エピジェネティクス, 服部奈緒子; 大鐘潤; 塩田邦郎, 2006, 化学と生物, 44, 12, 841, 850

  DOI
• 【Epigeneticsと疾患】エピジェネティクスの基礎 発生・生殖とエピジェネティクス, 服部 奈緒子; 塩田 邦郎, May 2003, 35, 5, 977, 984
• Differentiation of trophoblast lineage is associated with DNA methylation and demethylation., J. Ohgane; N. Hattori; M. Oda; S. Tanaka; K. Shiota, 2002, 290, 2, 701, 706

  DOI

Books etc

• 実験医学別冊：論文図表を読む作法, Contributor, Jul. 2022
• Epigenetic Epidemiology: Epigenetic epidemiology of infectious diseases, Joint work, Ushijima T; Furuichi Y; Takeshima H; Hattori N, Springer Nature, Apr. 2022
• がん生物学イラストレイテッド第2版, Joint work, Aug. 2019
• Methods in Molecular Biology, Contributor, Hattori N; Ushijima T, Inflammation and Cancer: Analysis of DNA methylation in tissues exposed to inflammation, Jan. 2018
• エピジェネティクス実験スタンダード : もう悩まない!ゲノム機能制御の読み解き方, Contributor, Jun. 2017, 394p, ISBN: 9784758101998
• DNAメチル化研究法, Contributor, Dec. 2006, xi, 250p, ISBN: 4762230529

Presentations

• Epigenomic Alterations in Normal Tissue Ecosystems and their Impact on Carcinogenesis, Naoko Hattori , Yoshimi Yasukawa , Yu-Yu Liu , Toshikazu Ushijima, The 83rd Annual Meeting of the Japanese Cancer Association, 20 Sep. 2024, English
• 環境要因による正常組織エコシステムのエピゲノム変化と発がんへの影響, 服部奈緒子 , リュウ ユユ , 安川佳美 , 牛島俊和, 第51回日本毒性学会学術年会, 03 Jul. 2024
• Current status and future prospects of academia drug discovery targeting epigenome abnormality, 服部奈緒子、安川佳美、牛島俊和, 日本薬学会第144年会, 29 Mar. 2024, 29 Mar. 2024, 31 Mar. 2024, Japanese
• 組織微小環境のエピゲノム変化と発がんへの影響, 服部奈緒子; 安川佳美; 牛島俊和, 第46回日本分子生物学会年会, 06 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023, Japanese
• ES細胞のエピゲノム複製に関与するヒストンリーダーの同定, 服部奈緒子; Yu-Yu Liu; 奥 輝明; 小泉美帆; 本田浩章; 牛島俊和, 第96回日本生化学会大会, 01 Nov. 2023, 31 Oct. 2023, 02 Nov. 2023, Japanese
• Epigenetic alterations in cancer ecosystem contribute to determination of cancer cell phenotype, Naoko Hattori; Yoshimi Yasukawa; Yu-Yu Liu; Satoshi Yamashita; Toshikazu Ushijima, 第82回日本癌学会, 21 Sep. 2023, 21 Sep. 2023, 23 Sep. 2023, English
• 慢性炎症シグナルによる正常細胞におけるエピジェネティクス修飾変化の誘発, 服部奈緒子; リュウ ユユ; 竹島秀幸; 牛島俊和, 第53回日本神経精神薬理学会年会, 09 Sep. 2023, 07 Sep. 2023, 09 Sep. 2023, Japanese
• HSD17B4のDNAメチル化による脂肪酸組成異常とHER2標的薬感受性機構の解明, 服部奈緒子; 新井信晃; 山下聡; 牛島俊和, 第9回がんと代謝研究会, 01 Jun. 2023, 31 May 2023, 01 Jun. 2023, Japanese
• Epigenomic alterations in tumor ecosystems in response to intrinsic and extrinsic factors, Naoko Hattori; Yu-Yu Liu; Yoshimi Yasukawa; Hideyuki Takeshima; Toshikazu Ushijima, Scientific Session at the Society of Toxicology (SOT) 62nd Annual Meeting, 21 Mar. 2023, 20 Mar. 2023, 23 Mar. 2023, English
• iChmo法を用いた単一細胞のヒストン修飾組合せの可視化, 服部奈緒子, 第39回日本毒性病理学会学術総会, 25 Jan. 2023, 25 Jan. 2023, 26 Jan. 2023, Japanese
• クロモドメインタンパクによる幹細胞のH3K9me3パターン形成, 服部奈緒子; Yu-Yu Liu; 木村佳那; 小泉美帆; 本田浩章; 牛島俊和, 第45回日本分子生物学会年会, 30 Nov. 2022
• 正常組織エコシステムのエピゲノム変化と発がんへの関与, 服部奈緒子; リュウ ユユ; 安川佳美; 牛島俊和, 第95回日本生化学会大会, 09 Nov. 2022
• DNA methylation of HSD17B4 alters cell membrane homeostasis, which may enhance drug sensitivity in breast cancer cells, 服部奈緒子; 新井信晃; 山下聡; 向井博文; 牛島俊和, 第81回日本癌学会学術総会, 01 Oct. 2022, 29 Sep. 2022, 01 Oct. 2022
• ES細胞の維持に関与するエピゲノム形成メカニズムとその破綻, 服部奈緒子, 第115回日本繁殖生物学会, 12 Sep. 2022, Japanese
• HSD17B4遺伝子のDNAメチル化は乳がん細胞の細胞膜環境を変化させて抗がん剤の奏功性に関与する, 服部奈緒子; 新井信晃; 山下智; 牛島俊和, 第4回がんと代謝研究会, 20 Jul. 2022, 19 Jul. 2022, 22 Jul. 2022
• 環境要因による正常組織エコシステムにおけるエピゲノム変化, 服部奈緒子; リュウ ユユ; 安川佳美; 竹島秀幸; 牛島俊和, 第49回日本毒性学会学術年会, 30 Jun. 2022, 30 Jun. 2022, 02 Jul. 2022, Japanese
• 環境要因によるエピゲノム撹乱と発がんへの関与, 服部奈緒子, 環境エピゲノミクス研究会ネットシンポジウム2022, 18 Jun. 2022, Japanese
• Involvement of a chromodomain protein, Cdyl2, in H3K9me3 pattern formation in mouse embryonic stem cells, Naoko Hattori; Yu-Yu Liu; Kana Kimura; Miho Koizumi; Hiroaki Honda; Toshikazu Ushijima, 第15回日本エピジェネティクス研究会年会, 09 Jun. 2022, 09 Jun. 2022, 10 Jun. 2022, Japanese
• Identification of a histone reader involved in the memory system of stem cell epigenome, Naoko Hattori, 第44回日本分子生物学会年会, Dec. 2021
• Identification of bivalent chromatin domain in senescent cells, Naoko Hattori, 第80回日本癌学会学術総会, 30 Sep. 2021, English
• エピジェネティクス撹乱要因による発がん機構とその制御, 第3回環境エピジェネティクス交流会, 19 Jun. 2021, Japanese
• がんゲノム医療におけるリキッドバイオプシーの基礎から応用, 株式会社R&D支援センターセミナー, 11 Jun. 2021, Japanese
• 幹細胞の多能性維持に関与するヒストンリーダーCdyl2の同定, 第14回日本エピジェネティクス研究会年会, 30 Mar. 2021, Japanese
• リキッドバイオプシーを中心としたがんゲノム医療の現在, （株）情報機構主催セミナー., 18 Feb. 2021, Japanese
• Visualization of multivalent histone modification in cellular differentiation and cellular senescence, 第43回日本分子生物学会年会, Dec. 2020, English
• DNA methylation of HSD17B4 is involved in drug sensitivity of breast cancer through metabolic shift, 第79回日本癌学会学術総会, 02 Oct. 2020, English
• Novel prodrugs of decitabine with greater metabolic stability and less toxicity, Post-A3 Meeting 2020, 19 Sep. 2020, English
• ゲノム・エピゲノム情報を利用した創薬の最新情報と今後の展望〜次世代シークエンスやシングルセル解析の事例、医療への関わり〜, （株）情報機構主催セミナー, 20 Feb. 2020
• 幹細胞の多能性維持に関与するヒストンリーダーCdyl2の同定, 第42回日本分子生物学会年会, Dec. 2019, Japanese
• Identification of a chromodomain protein, Cdyl2, involved in pluripotency of stem cells, Abcam Epigenetics Conference and 14th Asia Epigenome Meeting, Oct. 2019
• Identification of Environmental Factors that Induce Aberrant DNA Methylation, 第78回日本癌学会学術総会, Sep. 2019, English
• HSD17B4遺伝子のDNAメチル化は酸化的リン酸化反応を優位にして抗がん剤の奏功性に関与する, 第7回がんと代謝研究会, Aug. 2019
• Cdyl2 is a chromodomain protein involved in pluripotency of stem cells, Post-A3 Meeting 2019, Jul. 2019
• クロモドメインタンパクCdyl2は幹細胞の多能性維持に重要である, 第13回日本エピジェネティクス研究会年会, May 2019
• マウスES細胞の分化開始機序に関わるヒストンリーダーの同定, 第41回日本分子生物学会年会, Nov. 2018
• A preclinical study of epigenetic drug-based differentiation therapy for neuroblastoma, Post-A3 Meeting 2018, Nov. 2018, English
• Epigenome Reprogramming as a Basis for Combination Therapy, The Fourth Shanghai International Workshop of Epigenetics in Development and Diseases/ The 13th Annual Meeting of Asian Epigenome Alliance, 18 Sep. 2018, English
• がん幹細胞の特性に関わるヒストンリーダーの同定, 第77回日本癌学会学術総会, Sep. 2018
• クロモドメインタンパクCdyl2は幹細胞エピゲノムのリーダーである, 第12回日本エピジェネティクス研究会年会, May 2018
• Preclinical study of epigenetic drug-based differentiation therapy for neuroblastom, AACR Special Conference on Targeting DNA Methylation and Chromatin for Cancer Therapy, Mar. 2018
• A preclinical study of epigenetic drug-based differentiation therapy for neuroblastoma, Advances in Neuroblastoma Research (ANR) 2018 Conference, Mar. 2018
• マウスES細胞の分化開始機序に関わるヒストンリーダーの同定, 第41回日本分子生物学会年会, Dec. 2017
• エピジェネティック異常を標的としたがん予防, 第40回日本分子生物学会年会・第90回日本生化学会大会, Dec. 2017, Japanese
• 環境要因によるエピジェネティクス撹乱とがん予防を目指したその制御, 日本環境変異原学会第46回大会, 07 Nov. 2017
• CDYL2 is a chromodomain protein involved in reading of stem cell epigenome, The 72nd Fujihara Seminar, Nov. 2017
• Epigenome reprogramming as a basis for combination therapy, 第76回日本癌学会学術総会, Oct. 2017, English
• CDYL2 is a chromodomain protein involved in the regulation of stem cell propertie, 12th Asian Epigenomics Meeting, Sep. 2017
• CDYL2 is a chromodomain protein involved in the regulation of stem cell properties, Post-A3 Meeting 2017, Jul. 2017
• クロモドメインタンパクCdyl2はがん幹細胞の機能を調節している, 第11回日本エピジェネティクス研究会年会, May 2017
• Cdyl2 is a chromodomain protein involved in the maintenance of pluripotency of stem cells, Annual Meeting of AACR, Apr. 2017
• Development of novel DNA demethylating agents with greater stability and less toxicity, 28th EORTC-NCI-AACR Symposium, Dec. 2016
• Cdyl2 is a chromodomain protein involved in stem cell pluripotency: potential role in cancer stem cells, 第75回日本癌学会学術総会, Oct. 2016, English
• Establishment of the combination strategy of a DNA demethylating agent and a cytotoxic drug for gastric cancer, 26th Seoul International Cancer Symposium, Jun. 2016
• 幹細胞におけるエピゲノム修飾の可視化とヒストンリーダーの解析, 第10回日本エピジェネティクス研究会年会, May 2016, Japanese
• Preclinical study of epigenetic drug-based differentiation therapy for neuroblastoma, Annual Meeting of AACR, Apr. 2016
• クロモドメインタンパクCdyl2はES細胞の未分化性維持に関与している, 第38回日本分子生物学会年会, Dec. 2015, Japanese
• Preclinical study of DNA demethylation therapy for neuroblastoma, 第74回日本癌学会学術総会, Oct. 2015
• Molecular Characteristics of Gastric Cancer-Associated Fibroblasts, 第73回日本癌学会学術総会, Sep. 2014
• Molecular Characteristics of Gastric Cancer-Associated Fibroblasts, JSPS A3 Foresight Program 2014 Kyoto Meeting, May 2014
• Establishment of a Novel Method to Visualize a Combination of Histone Modifications, 2014 GRL meeting, Feb. 2014
• Cell Cycle-dependence of a Combination of Heterochromatin Marks in Normal and Cancer Cells, 8th Annual Conference of Asia Epigenome Alliance/2nd Taipei Epigenetics and Chromatin Meeting, Nov. 2013
• がんにおけるエピジェネティクスの重要性と診断・治療への応用, 第7回緩和医療薬学会年会, 16 Sep. 2013
• Studies for Bivalent Histone Modification and Cancer-Prone Niche, National Research Foundation of Korea A3 Foresight Program 2013 Seminar, Jul. 2013
• Visualization of multivalent histone modification in a single cell, and its application, Gordon Research Conference, Apr. 2013
• Applications of iChmo to Analyzing Novel Biological Phenomema, JSPS A3 Foresight Program 2013 Sapporo Meeting, Mar. 2013
• Visualization of a combination of histone modifications in a single cell, The 2nd Epigenomics of Common Diseases Conference, Oct. 2012
• Development of a novel technique to visualize combination of histone modifications, 第71回日本癌学会学術総会, Sep. 2012
• Development of a novel technique to visualize a combination of histone modifications, ISSCR 10th Annual Meeting, Jun. 2012, English
• Development of a novel technique to visualize a combination of histone modifications, A3 Foresight Program 2012 Seminar, Jun. 2012
• ヒストン修飾の組合せの可視化技術の開発, 第34回日本分子生物学年会, Dec. 2011
• Identification of genes with promoter methylation in rat mammary carcinomas by a combination of DNA methylation microarray and expression microarray, International Symposium "Sex-differences in Epigenetics and Epigenomics", 11 Sep. 2011, English
• 網羅的DNAメチル化解析および遺伝子発現解析を用いたラット乳がんでの異常DNAメチル化の同定, 平成22年度個体レベルでのがん研究支援活動ワークショップ, Feb. 2011
• Screening of promoter CpG islands methylated in human mammary epithelial cells, NSFC A3 foresight program 2010 seminar, Sep. 2010
• Identification of five genes with promoter methylation in rat mammary carcinomas by a combination of DNA methylation microarray and expression microarray, The XVIIIth International Workshop on Genetic Systems in the Rat, Sep. 2010
• Identification of a gene silenced in rat mammary carcinomas by combination of DNA methylation microarray and chemical genomic screening, 101st Annual Meeting of American Association for Cancer Research, Apr. 2010
• Identification of a gene silenced in rat mammary carcinomas by a combination of DNA methylation microarray and chemical genomic screening, JSPS A3 foresight program 2010 seminar, Feb. 2010

Industrial Property Rights

• Patent right, JP2018016514, 24 Apr. 2018, ; , WO2018-199049, 01 Nov. 2018
• Patent right, JP2004002914, 05 Mar. 2004, ; , WO2004-078971, 16 Sep. 2004

Awards

• EMBO Poster Clinic Prize, Involvement of a chromodomain protein in H3K9me3 pattern formation of stem cells, Dec. 2022
• 2019
• 2015
• 2007

Research Projects

• 01 Apr. 2024, 31 Mar. 2027, 24K10366

  対象リソースIRI
• Apr. 2023, Mar. 2026, Coinvestigator, 23K06744

  対象リソースIRI
• Jan. 2024, Dec. 2025, Principal investigator
• May 2024, Sep. 2025, Principal investigator
• 01 Apr. 2022, 31 Mar. 2024, 22H04705

  対象リソースIRI
• Apr. 2020, Mar. 2023, Coinvestigator, 20K07593

  対象リソースIRI
• Establishment of an imaging system for environment-induced epigenome alterations, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), National Cancer Center Japan, Apr. 2020, Mar. 2023, Principal investigator, 20K07628

  対象リソースIRI
• Development of new drugs and elucidation of immunity to cure all chronic myeloid leukemia patients, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Saga University, Apr. 2020, Mar. 2023, Coinvestigator, 20K08756

  対象リソースIRI
• Apr. 2019, Mar. 2022, Coinvestigator, JP19ck0106466
• Involvement of lnc162 on sensitivity to DNA demethylating agents, Ushijima Toshikazu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), National Cancer Center Japan, Apr. 2018, Mar. 2021, Coinvestigator, DNA demethylation therapy is now expanding from hematological tumors to solid tumors. Previously, we have identified a long noncoding RNA, linc00162 (lnc162), as highly and frequently expressed in gastric cancer cell lines sensitive to 5-aza-2′-deoxycytidine (5-aza-dC). Here, we aimed to reveal the molecular mechanisms how lnc162 is involved in 5-aza-dC sensitivity and the function of lnc162 in other solid tumors. In vivo experiments showed that lnc162 overexpression increased the sensitivity. Mechanistically, lnc162 interacted with an RNA splicing protein, HNRNPH1, and decreased splicing of an anti-apoptotic splicing variant, BCL-XL. In liposarcomas cell lines, lnc162 expression was induced by the treatment of 5-aza-dC, meaning that the involvement of lnc162 in 5-aza-dC sensitivity is universally applicable to solid tumors. lnc162 may have translational value to predict patients who will respond to 5-aza-dC. We have published these findings as an original paper., 18H02704

  対象リソースIRI
• 2020, 2021, Principal investigator
• Investigation of the role of histone reader in cancer stem cells and application of its inhibition to modulate differentiation ability of cancer stem cells, Hattori Naoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), National Cancer Center Japan, Apr. 2017, Mar. 2020, Principal investigator, In this study, to develop therapeutic strategy for cancer stem cells by targeting histone reader, we explored the role of human CDYL2 in cancer stem cells (CSCs). Expression of exogenous CDYL2 increased the CSC population in two breast and three colorectal cancer cell lines, and upregulated genes involved in cancer invasion and cancer metastasis. On the other hand, CDYL2-knock-out decreased CSC population in colorectal cancer cells, and its reduction was cancelled by CDYL2-rescue. The effect of CDYL2 expression on drug sensitivity was also investigated. In breast cancer cells with CDYL2-overexpression, the sensitivity to 5-FU was significantly decreased, and in CDYL2-knock-out colorectal cancer cells, the sensitivities to 5-FU and irinotecan were enhanced, indicating the possibility of a combination therapy of CDYL2 inhibitor and cytotoxic drugs. These data demonstrate that CDYL2 is important for maintenance of cancer stem cells., 17K07190

  対象リソースIRI
• Involvement of bivalent histone modification in age-specific cancer susceptibility, Hattori Naoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), National Cancer Center Japan, Apr. 2015, Mar. 2017, Principal investigator, To reveal the molecular mechanism of age-specific cancer susceptibility of mammary glands, I investigated the involvement of bivalent histone modification. ChIP-chip analysis of H3K4me3 and H3K27me3 using rat mammary epithelial cells showed that 91 genes were identified as the bivalent genes in sensitive period. Among the 91 genes, 7 genes were methylated in rat mammary carcinomas, and 4 genes did not express in normal mammary epithelial cells. The human homolog of one gene was known as a tumor suppressor gene that is methylation-silenced in breast cancer. I identified the sensitive period-specific bivalent genes in mammary gland, which were methylated in mammary carcinoma, suggesting that bivalent modification might be a seed of DNA methylation during carcinogenesis., 15K18420

  対象リソースIRI
• 2014, 2016, Principal investigator
• Involvement of histone reader proteins in maintenance of pluripotency of normal and cancer stem cells, HATTORI Naoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), National Cancer Center Japan, Apr. 2013, Mar. 2015, Principal investigator, In this study, to identify histone reader proteins involved in the maintenance of pluripotency of normal and cancer stem cells, we analyzed the function of chromodomain protein, Cdyl2. Mouse embryonic stem cells (ESC) with Cdyl2 reduction by knock down system and with increase expression of exogenous Cdyl2 showed that the differentiation ability of ESC was perturbed by the change of Cdyl2 expression level. ChIP assay revealed that Cdyl2 was enriched at the promoter regions of differentiation-associated genes. Furthermore, immunoprecipitation-western blotting showed that Cdyl2 co-localized with EZH2, and recognized H3K27me3. These findings demonstrate that Cdyl2 is involved in the maintenance of pluripotency in ESC, and suggest that Cdyl2 represses development-associated genes to keep an undifferentiated state., 25830094

  対象リソースIRI
• 2004, 2006, Principal investigator, 04J11105

  対象リソースIRI

Educational Activities

Teaching Experience

• Jun. 2023, Jul. 2023
• Jul. 2023
• Jun. 2022
• Jul. 2021
• Nov. 2007