Researcher Profile and Settings

Researcher

• Name

  KAMITANI Wataru

Affiliation

• Parasitology, Professor

Profile and Settings

• Name

  Kamitani, Wataru

Affiliation

• Gunma University, Graduate School of Medicine

Affiliation

• Affiliation

  Graduate School of Medicine

Education

• Apr. 1999, Mar. 2003, Osaka University, Graduate School of Medicine
• Apr. 1993, Mar. 1999, Rakuno Gakuen University

Research Experience

• Oct. 2019, 9999, Gunma University, Graduate School of Medicine, Prof lv
• Apr. 2013, Sep. 2019, 大阪大学/微生物病研究所, Associate prof lecturer lv
• Apr. 2009, Mar. 2013, 大阪大学/微生物病研究所, Associate prof lecturer lv
• May 2004, Mar. 2009, Researcher postdoc lv

Research Activities

Research Areas

• Life sciences, Virology

Published Papers

• 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents., Sho Konno; Kiyotaka Kobayashi; Miki Senda; Yuta Funai; Yuta Seki; Ikumi Tamai; Laura Schäkel; Kyousuke Sakata; Thanigaimalai Pillaiyar; Akihiro Taguchi; Atsuhiko Taniguchi; Michael Gütschow; Christa E Müller; Koh Takeuchi; Mikako Hirohama; Atsushi Kawaguchi; Masaki Kojima; Toshiya Senda; Yoshiyuki Shirasaka; Wataru Kamitani; Yoshio Hayashi, 27 Jul. 2021, Journal of medicinal chemistry, 65, 4, 2926, 2939, Scientific journal

  DOI
• Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection., Masateru Taniguchi; Shohei Minami; Chikako Ono; Rina Hamajima; Ayumi Morimura; Shigeto Hamaguchi; Yukihiro Akeda; Yuta Kanai; Takeshi Kobayashi; Wataru Kamitani; Yutaka Terada; Koichiro Suzuki; Nobuaki Hatori; Yoshiaki Yamagishi; Nobuei Washizu; Hiroyasu Takei; Osamu Sakamoto; Norihiko Naono; Kenji Tatematsu; Takashi Washio; Yoshiharu Matsuura; Kazunori Tomono, 17 Jun. 2021, Nature communications, 12, 1, 3726, 3726, Scientific journal

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• Long-term acrylamide exposure exacerbates brain and lung pathology in a mouse malaria model., Ha Ngo-Thanh; Trang Dam Thuy; Kazutomo Suzue; Wataru Kamitani; Hideaki Yokoo; Koji Isoda; Chikako Shimokawa; Hajime Hisaeda; Takashi Imai, May 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 151, 112132, 112132, Scientific journal

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• Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction., Shiho Torii; Chikako Ono; Rigel Suzuki; Yuhei Morioka; Itsuki Anzai; Yuzy Fauzyah; Yusuke Maeda; Wataru Kamitani; Takasuke Fukuhara; Yoshiharu Matsuura, 20 Apr. 2021, Cell reports, 35, 3, 109014, 109014, Scientific journal

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• Roles of OmpX, an outer membrane protein on virulence and flagellar expression in uropathogenic Escherichia coli., Hidetada Hirakawa; Kazutomo Suzue; Ayako Takita; Wataru Kamitani; Haruyoshi Tomita, 22 Mar. 2021, Infection and immunity, 89, 6, Scientific journal

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• Neutralizing and binding activities against SARS-CoV-1/2, MERS-CoV, and human coronaviruses 229E and OC43 by normal human intravenous immunoglobulin derived from healthy donors in Japan., Ritsuko Kubota-Koketsu; Yutaka Terada; Mikihiro Yunoki; Tadahiro Sasaki; Emi E Nakayama; Wataru Kamitani; Tatsuo Shioda, Feb. 2021, Transfusion, 61, 2, 356, 360, Scientific journal

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• Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth., Makoto Ujike; Yukako Kawachi; Yui Matsunaga; Yuka Etho; Hideki Asanuma; Wataru Kamitani; Fumihiro Taguchi, 13 Jan. 2021, Journal of virology, 95, 3, Scientific journal

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• The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells., Shutoku Matsuyama; Miyuki Kawase; Naganori Nao; Kazuya Shirato; Makoto Ujike; Wataru Kamitani; Masayuki Shimojima; Shuetsu Fukushi, 09 Dec. 2020, Journal of virology, 95, 1, Scientific journal

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• Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA., Ha Ngo-Thanh; Tsutomu Sasaki; Kazutomo Suzue; Hideaki Yokoo; Koji Isoda; Wataru Kamitani; Chikako Shimokawa; Hajime Hisaeda; Takashi Imai, Dec. 2020, International journal for parasitology, 50, 14, 1167, 1175, Scientific journal

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• Molecular pharmacology of ciclesonide against SARS-CoV-2., Hirokazu Kimura; Hiromu Kurusu; Mitsuru Sada; Daisuke Kurai; Koichi Murakami; Wataru Kamitani; Haruyoshi Tomita; Kazuhiko Katayama; Akihide Ryo, Aug. 2020, The Journal of allergy and clinical immunology, 146, 2, 330, 331

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• Middle East Respiratory Syndrome Coronavirus in Dromedaries in Ethiopia Is Antigenically Different From the Middle East Isolate EMC., Kazuya Shirato; Simenew Keskes Melaku; Kengo Kawachi; Naganori Nao; Naoko Iwata-Yoshikawa; Miyuki Kawase; Wataru Kamitani; Shutoku Matsuyama; Tesfaye Sisay Tessema; Hiroshi Sentsui, 2019, Frontiers in microbiology, 10, 10, 1326, 1326, Scientific journal

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• Development of fluorescent reverse transcription loop-mediated isothermal amplification (RT-LAMP) using quenching probes for the detection of the Middle East respiratory syndrome coronavirus, Kazuya Shirato; Shohei Semba; Sherif A. El-Kafrawy; Ahmed M. Hassan; Ahmed M. Tolah; Ikuyo Takayama; Tsutomu Kageyama; Tsugunori Notomi; Wataru Kamitani; Shutoku Matsuyama; Esam Ibraheem Azhar, 01 Aug. 2018, Journal of Virological Methods, 258, 41, 48, Scientific journal

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• Identification and analysis of host proteins that interact with the 3′-untranslated region of tick-borne encephalitis virus genomic RNA, Memi Muto; Wataru Kamitani; Mizuki Sakai; Minato Hirano; Shintaro Kobayashi; Hiroaki Kariwa; Kentaro Yoshii, Apr. 2018, Virus Research, 249, 52, 56, Scientific journal

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• Construction of a high-yield dengue virus by replacing nonstructural proteins 3–4B without increasing virulence, Supranee Phanthanawiboon; Sabar Pambudi; Magot Diata Omokoko; Keiko Hanabara; Atchareeya A-nuegoonpipat; Wataru Kamitani; Kazuyoshi Ikuta; Takeshi Kurosu, 01 Jan. 2018, Biochemical and Biophysical Research Communications, 495, 1, 1221, 1226, Scientific journal

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• Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane, Ming Chen; Chie Aoki-Utsubo; Masanori Kameoka; Lin Deng; Yutaka Terada; Wataru Kamitani; Kei Sato; Yoshio Koyanagi; Makoto Hijikata; Keiko Shindo; Takeshi Noda; Michinori Kohara; Hak Hotta, Nov. 2017, SCIENTIFIC REPORTS, 7, 1, 15931, Scientific journal

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• MERS coronavirus nsp1 participates in an efficient propagation through a specific interaction with viral RNA, Yutaka Terada; Kengo Kawachi; Yoshiharu Matsuura; Wataru Kamitani, Nov. 2017, VIROLOGY, 511, 95, 105, Scientific journal

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• Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication, Yusuke Sakai; Kengo Kawachi; Yutaka Terada; Hiroko Omori; Yoshiharu Matsuura; Wataru Kamitani, Oct. 2017, VIROLOGY, 510, 165, 174, Scientific journal

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• Nonstructural protein p39 of feline calicivirus suppresses host innate immune response by preventing IRF-3 activation, Yo Yumiketa; Takanori Narita; Yosuke Inoue; Go Sato; Wataru Kamitani; Tomoichiro Oka; Kazuhiko Katayama; Takemasa Sakaguchi; Yukinobu Tohya, Mar. 2016, VETERINARY MICROBIOLOGY, 185, 62, 67, Scientific journal

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• Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation, Hiroshi Katoh; Toru Okamoto; Takasuke Fukuhara; Hiroto Kambara; Eiji Morita; Yoshio Mori; Wataru Kamitani; Yoshiharu Matsuura, Jan. 2013, JOURNAL OF VIROLOGY, 87, 1, 489, 502, Scientific journal

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• Severe Acute Respiratory Syndrome Coronavirus nsp1 Facilitates Efficient Propagation in Cells through a Specific Translational Shutoff of Host mRNA, Tomohisa Tanaka; Wataru Kamitani; Marta L. DeDiego; Luis Enjuanes; Yoshiharu Matsuura, Oct. 2012, JOURNAL OF VIROLOGY, 86, 20, 11128, 11137, Scientific journal

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• Establishment of a Novel Permissive Cell Line for the Propagation of Hepatitis C Virus by Expression of MicroRNA miR122, Hiroto Kambara; Takasuke Fukuhara; Mai Shiokawa; Chikako Ono; Yuri Ohara; Wataru Kamitani; Yoshiharu Matsuura, Feb. 2012, JOURNAL OF VIROLOGY, 86, 3, 1382, 1393, Scientific journal

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• Heterogeneous Nuclear Ribonucleoprotein A2 Participates in the Replication of Japanese Encephalitis Virus through an Interaction with Viral Proteins and RNA, Hiroshi Katoh; Yoshio Mori; Hiroto Kambara; Takayuki Abe; Takasuke Fukuhara; Eiji Morita; Kohji Moriishi; Wataru Kamitani; Yoshiharu Matsuura, Nov. 2011, JOURNAL OF VIROLOGY, 85, 21, 10976, 10988, Scientific journal

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• A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein, Wataru Kamitani; Cheng Huang; Krishna Narayanan; Kumari G. Lokugamage; Shinji Makino, Nov. 2009, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 16, 11, 1134, U2, Scientific journal

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• A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein, Wataru Kamitani; Cheng Huang; Krishna Narayanan; Kumari G Lokugamage; Shinji Makino, Nov. 2009, Nature Structural and Molecular Biology, 16, 11, 1134, 1140, Scientific journal

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• Suppression of Host Gene Expression by nsp1 Proteins of Group 2 Bat Coronaviruses, Yukinobu Tohya; Krishna Narayanan; Wataru Kamitani; Cheng Huang; Kumari Lokugamage; Shinji Makino, May 2009, JOURNAL OF VIROLOGY, 83, 10, 5282, 5288, Scientific journal

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• Rift Valley Fever Virus NSs Protein Promotes Post-Transcriptional Downregulation of Protein Kinase PKR and Inhibits eIF2 alpha Phosphorylation, Tetsuro Ikegami; Krishna Narayanan; Sungyong Won; Wataru Kamitani; C. J. Peters; Shinji Makino, Feb. 2009, PLOS PATHOGENS, 5, 2, e1000287, Scientific journal

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• Dual Functions of Rift Valley Fever Virus NSs Protein: Inhibition of Host mRNA Transcription and Post-transcriptional Downregulation of Protein Kinase PKR, Tetsuro Ikegami; Krishna Narayanan; Sungyong Won; Wataru Kamitani; C. J. Peters; Shinji Makino, 2009, IMMUNOLOGY AND PATHOGENESIS OF VIRAL HEMORRHAGIC FEVERS, 1171, S1, E75, E85, Scientific journal

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• Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells, Krishna Narayananj; Cheng Huang; Kumari Lokugamage; Wataru Kamitani; Tetsuro Ikegami; Chien-Te K. Tseng; Shinji Makino, May 2008, JOURNAL OF VIROLOGY, 82, 9, 4471, 4479, Scientific journal

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• Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces vascular inflammatory responses in brains persistently infected with Borna disease virus, Naohiro Ohtaki; Wataru Kamitani; Yohei Watanabe; Yohei Hayashi; Hideyuki Yanai; Kazuyoshi Ikuta; Keizo Tomonaga, Jun. 2007, JOURNAL OF VIROLOGY, 81, 11, 5940, 5948, Scientific journal

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• Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility., Yohei Watanabe; Madiha S Ibrahim; Katsuro Hagiwara; Minoru Okamoto; Wataru Kamitani; Hideyuki Yanai; Naohiro Ohtaki; Yohei Hayashi; Hiroyuki Taniyama; Kazuyoshi Ikuta; Keizo Tomonaga, Apr. 2007, Microbes and infection, 9, 4, 417, 27, Scientific journal

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• Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation, Wataru Kamitani; Krishna Narayanan; Cheng Huang; Kumari Lokugamage; Tetsuro Ikegami; Naoto Ito; Hideyuki Kubo; Shinji Makino, Aug. 2006, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, 34, 12885, 12890, Scientific journal

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• Persistent Borna disease virus infection confers instability of HSP70 mRNA in glial cells during heat stress, M Yamashita; W Kamitani; H Yanai; N Ohtaki; Y Watanabe; BJ Lee; S Tsuji; K Ikuta; K Tomonaga, Feb. 2005, JOURNAL OF VIROLOGY, 79, 4, 2033, 2041, Scientific journal

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• Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1, GQ Zhang; T Kobayashi; W Kamitani; S Komoto; M Yamashita; S Baba; H Yanai; K Ikuta; K Tomonaga, Nov. 2003, JOURNAL OF VIROLOGY, 77, 22, 12243, 12251, Scientific journal

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• Age- and host-dependent control of Borna disease virus spread in the developing brains of gerbils and rats, BJ Lee; M Watanabe; W Kamitani; S Baba; M Yamashita; T Kobayashi; K Tomonaga; K Ikuta, Nov. 2003, MICROBES AND INFECTION, 5, 13, 1195, 1204, Scientific journal

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• Experimental vertical transmission of Borna disease virus in the mouse, M Okamoto; K Hagiwara; W Kamitani; T Sako; K Hirayama; R Kirisawa; M Tsuji; C Ishihara; H Iwai; T Kobayashi; K Tomonaga; K Ikuta; H Taniyama, Aug. 2003, ARCHIVES OF VIROLOGY, 148, 8, 1557, 1568, Scientific journal

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• Modulation of Borna disease virus phosphoprotein nuclear localization by the viral protein X encoded in the overlapping open reading frame, T Kobayashi; GQ Zhang; BJ Lee; S Baba; M Yamashita; W Kamitani; H Yanai; K Tomonaga; K Ikuta, Jul. 2003, JOURNAL OF VIROLOGY, 77, 14, 8099, 8107, Scientific journal

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• Glial expression of Borna disease virus phosphoprotein induces behavioral and neurological abnormalities in transgenic mice, W Kamitani; E Ono; S Yoshino; T Kobayashi; S Taharaguchi; BJ Lee; M Yamashita; T Kobayashi; M Okamoto; H Taniyama; K Tomonaga; K Ikuta, Jul. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 15, 8969, 8974, Scientific journal

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• Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell destructions, M Watanabe; BJ Lee; M Yamashita; W Kamitani; T Kobayashi; K Tomonaga; K Ikuta, Jun. 2003, VIROLOGY, 310, 2, 245, 253, Scientific journal

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• Borna disease in a dog in Japan, M Okamoto; Y Kagawa; W Kamitani; K Hagiwara; R Kirisawa; H Iwai; K Ikuta; H Taniyama, May 2002, JOURNAL OF COMPARATIVE PATHOLOGY, 126, 4, 312, 317, Scientific journal

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• Varied persistent life cycles of Borna disease virus in a human oligodendroglioma cell line, MS Ibrahim; M Watanabe; JA Palacios; W Kamitani; S Komoto; T Kobayashi; K Tomonaga; K Ikuta, Apr. 2002, JOURNAL OF VIROLOGY, 76, 8, 3873, 3880, Scientific journal

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• Nosological study of Borna disease virus infection in race horses, K Hagiwara; M Okamoto; W Kamitani; S Takamura; H Taniyama; N Tsunoda; H Tanaka; H Iwai; K Ikuta, Feb. 2002, VETERINARY MICROBIOLOGY, 84, 4, 367, 374, Scientific journal

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• Borna disease in a heifer in Japan, M Okamoto; H Furuoka; K Hagiwara; W Kamitani; R Kirisawa; K Ikuta; H Taniyama, Jan. 2002, VETERINARY RECORD, 150, 1, 16, 18, Scientific journal
• Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1, W Kamitani; Y Shoya; T Kobayashi; M Watanabe; BJ Lee; GQ Zhang; K Tomonaga; K Ikuta, Sep. 2001, JOURNAL OF VIROLOGY, 75, 18, 8742, 8751, Scientific journal

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• Borna disease virus nucleoprotein requires both nuclear localization and export activities for viral nucleocytoplasmic shuttling, T Kobayashi; W Kamitani; GQ Zhang; M Watanabe; K Tomonaga; K Ikuta, Apr. 2001, JOURNAL OF VIROLOGY, 75, 7, 3404, 3412, Scientific journal

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• Equine Borna disease in Japan, H Taniyama; M Okamoto; K Hirayama; K Hagiwara; R Kirisawa; W Kamitani; N Tsunoda; K Ikuta, Apr. 2001, VETERINARY RECORD, 148, 15, 480, 482, Scientific journal
• Neurological diseases and viral dynamics in the brains of neonatally borna disease virus-infected gerbils, M Watanabe; BJ Lee; W Kamitani; T Kobayashi; H Taniyama; K Tomonaga; K Ikuta, Mar. 2001, VIROLOGY, 282, 1, 65, 76, Scientific journal

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• Identification of alternative splicing and negative splicing activity of a nonsegmented negative-strand RNA virus, Borna disease virus, K Tomonaga; T Kobayashi; BJ Lee; M Watanabe; W Kamitani; K Ikuta, Nov. 2000, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97, 23, 12788, 12793, Scientific journal

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• Translation initiation of a bicistronic mRNA of borna disease virus: A 16-kDa phosphoprotein is initiated at an internal start codon, T Kobayashi; M Watanabe; W Kamitani; K Tomonaga; K Ikuta, Nov. 2000, VIROLOGY, 277, 2, 296, 305, Scientific journal

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• Detection of Borna disease virus in a pregnant mare and her fetus, K Hagiwara; W Kamitani; S Takamura; H Taniyama; T Nakaya; H Tanaka; R Kirisawa; H Iwai; K Ikuta, Mar. 2000, VETERINARY MICROBIOLOGY, 72, 3-4, 207, 216, Scientific journal

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• Molecular ratio between borna disease viral-p40 and-p24 proteins in infected cells determined by quantitative antigen capture ELISA, M Watanabe; Q Zhong; T Kobayashi; W Kamitani; K Tomonaga; K Ikuta, 2000, MICROBIOLOGY AND IMMUNOLOGY, 44, 9, 765, 772, Scientific journal

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• Single Amino Acid Substitution in the Receptor Binding Domain of Spike Protein Is Sufficient To Convert the Neutralization Profile between Ethiopian and Middle Eastern Isolates of Middle East Respiratory Coronavirus, Satoko Sugimoto; Masatoshi Kakizaki; Miyuki Kawase; Kengo Kawachi; Makoto Ujike; Wataru Kamitani; Hiroshi Sentsui; Kazuya Shirato, 06 Feb. 2023, Microbiology Spectrum, Scientific journal

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• Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein, Ryota Otsubo; Takeharu Minamitani; Kouji Kobiyama; Junso Fujita; Toshihiro Ito; Shiori Ueno; Itsuki Anzai; Hiroki Tanino; Hiroshi Aoyama; Yoshiharu Matsuura; Keiichi Namba; Ken-Ichi Imadome; Ken J. Ishii; Kouhei Tsumoto; Wataru Kamitani; Teruhito Yasui, 22 Nov. 2022, Scientific Reports, 12, 1, 20120, 20120, Scientific journal

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• Versatile live-attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity., Akiho Yoshida; Shinya Okamura; Shiho Torii; Sayuri Komatsu; Paola Miyazato; Hitomi Sasaki; Shiori Ueno; Hidehiko Suzuki; Wataru Kamitani; Chikako Ono; Yoshiharu Matsuura; Shiro Takekawa; Koichi Yamanishi; Hirotaka Ebina, 18 Nov. 2022, iScience, 25, 11, 105412, 105412, Scientific journal

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• A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in Enterohemorrhagic Escherichia coli, Which Attenuates Virulence., Hidetada Hirakawa; Kazutomo Suzue; Motoyuki Uchida; Ayako Takita; Wataru Kamitani; Haruyoshi Tomita, 2022, Frontiers in microbiology, 13, 883689, 883689, Scientific journal

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• Reverse Genetics with a Full-length Infectious cDNA Clone of Bovine Torovirus., Makoto Ujike; Yuka Etoh; Naoya Urushiyama; Fumihiro Taguchi; Hideki Asanuma; Luis Enjuanes; Wataru Kamitani, 24 Nov. 2021, Journal of virology, 96, 3, JVI0156121, Scientific journal

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• ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury., Tomokazu Yamaguchi; Midori Hoshizaki; Takafumi Minato; Satoru Nirasawa; Masamitsu N Asaka; Mayumi Niiyama; Masaki Imai; Akihiko Uda; Jasper Fuk-Woo Chan; Saori Takahashi; Jianbo An; Akari Saku; Ryota Nukiwa; Daichi Utsumi; Maki Kiso; Atsuhiro Yasuhara; Vincent Kwok-Man Poon; Chris Chung-Sing Chan; Yuji Fujino; Satoru Motoyama; Satoshi Nagata; Josef M Penninger; Haruhiko Kamada; Kwok-Yung Yuen; Wataru Kamitani; Ken Maeda; Yoshihiro Kawaoka; Yasuhiro Yasutomi; Yumiko Imai; Keiji Kuba, 23 Nov. 2021, Nature communications, 12, 1, 6791, 6791, Scientific journal

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• COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions., Emiko Urano; Tomotaka Okamura; Chikako Ono; Shiori Ueno; Satoshi Nagata; Haruhiko Kamada; Mahoko Higuchi; Mugi Furukawa; Wataru Kamitani; Yoshiharu Matsuura; Yoshihiro Kawaoka; Yasuhiro Yasutomi, 26 Oct. 2021, Proceedings of the National Academy of Sciences of the United States of America, 118, 43, Scientific journal

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• Adsorption of Phenazines Produced by Pseudomonas aeruginosa Using AST-120 Decreases Pyocyanin-Associated Cytotoxicity., Hidetada Hirakawa; Ayako Takita; Motoyuki Uchida; Yuka Kaneko; Yuto Kakishima; Koichi Tanimoto; Wataru Kamitani; Haruyoshi Tomita, 13 Apr. 2021, Antibiotics (Basel, Switzerland), 10, 4, Scientific journal

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• An artificial intelligence nanopore platform for SARS-CoV-2 virus detection, Masateru Taniguchi; Shohei Minami; Chikako Ono; Rina Hamajima; Ayumi Morimura; Shigeto Hamaguchi; Yukihiro Akeda; Yuta Kanai; Takeshi Kobayashi; Wataru Kamitani; Yutaka Terada; Koichiro Suzuki; Nobuaki Hatori; Yoshiaki Yamagishi; Nobuei Washizu; Hiroyasu Takei; Osamu Sakamoto; Norihiko Naono; Kenji Tatematsu; Takashi Washio; Yoshiharu Matsuura; Kazunori Tomono, 28 Oct. 2020

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• Establishment of a Virulent Full-Length cDNA Clone for Type I Feline Coronavirus Strain C3663., Yutaka Terada; Yudai Kuroda; Shigeru Morikawa; Yoshiharu Matsuura; Ken Maeda; Wataru Kamitani, 01 Nov. 2019, Journal of virology, 93, 21, Scientific journal

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• Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells., Matsuyama S; Shirato K; Kawase M; Terada Y; Kawachi K; Fukushi S; Kamitani W, Oct. 2018, Journal of virology, 92, 19

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• S1 Subunit of Spike Protein from a Current Highly Virulent Porcine Epidemic Diarrhea Virus Is an Important Determinant of Virulence in Piglets., Suzuki T; Terada Y; Enjuanes L; Ohashi S; Kamitani W, Aug. 2018, Viruses, 10, 9, 467, 467, Scientific journal

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• MERSコロナウイルスmRNAのUTRはnsp1との相互作用により、nsp1による翻訳抑制を回避する, 寺田 豊; 前田 健; 松浦 善治; 神谷 亘, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2LBA073], [2LBA073]
• RAGE機能阻害によるウイルス性脳炎の抑制, 大滝 尚広; 神谷 亘; 渡邊 洋平; 矢内 英之; 林 陽平; 生田 和良; 朝長 啓造, Aug. 2005, 140回, 101, 101
• ウシ由来BDV野外分離株の性状解析, 渡邊 洋平; 神谷 亘; 大滝 尚広; 矢内 英之; 林 陽平; 萩原 克郎; 岡本 実; 谷山 弘行; 生田 和良; 朝長 啓造, Aug. 2005, 140回, 102, 102
• Radioligand assayによる抗ボルナ病ウイルスIgGおよびIgMの検出, 松永 秀典; 田中 進; 網野 信行; 武田 雅俊; 神谷 亘; 朝長 啓造; 生田 和良, Sep. 2004, 9, 2, 73, 73
• BDV感染による糖化最終産物レセプター(RAGE)の発現動態の解析, 大滝 尚広; 神谷 亘; 李 丙載; 渡邊 洋平; 山下 真紀子; 矢内 英之; 生田 和良; 朝長 啓造, Mar. 2004, 137回, 96, 96
• BDV持続感染細胞にみられる核内ドット状構造物の動態とゲノム複製への役割, 矢内 英之; 神谷 亘; 李 丙載; 張 国旗; 山下 真紀子; 渡邊 洋平; 大滝 尚広; 生田 和良; 朝長 啓造, Mar. 2004, 137回, 96, 96
• ボルナ病ウイルス持続感染機序の解析, 朝長 啓造; 矢内 英之; 神谷 亘; 渡邊 洋平; 大滝 尚広; 李 丙載; 山下 真紀子; 生田 和良, Mar. 2004, 137回, 96, 96
• ウシにおけるボルナ病ウイルス疫学調査と野外分離株の性状解析, 渡邊 洋平; 神谷 亘; 李 丙載; 山下 真紀子; 大滝 尚広; 矢内 英之; 笹尾 芙蓉子; 岡本 実; 谷山 弘行; 荻原 克郎; 生田 和良; 朝長 啓造, Mar. 2004, 137回, 97, 97
• [Borna disease virus infection]., Kamitani W; Tomonaga K; Ikuta K, Feb. 2003, Nihon rinsho. Japanese journal of clinical medicine, 61 Suppl 2, 128, 134
• Basic information of Coronavirus, KAMITANI Wataru, 2020, Uirusu, 70, 1, 29, 36

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• COVID-19 and SARS Coronavirus-2, KAMITANI WATARU, Jun. 2021, Sen'i Gakkaishi, 77, 6, P-274, P-277

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• コロナウイルスとは, 神谷 亘, Dec. 2020, 21, 4, 189
• 【新型コロナ感染症パンデミック宣言とICU】SARS-CoV-2ウイルスの特徴, 神谷 亘, Nov. 2020, 44, 11, 677
• 【新型ウイルスの最新情報と対応】コロナウイルスの基礎ウイルス(遺伝子解析), 神谷 亘, Jan. 2021, 39, 1, 9
• 【COVID-19の病態・診断・治療　現場の知恵とこれからの羅針盤】(II章)COVID-19を理解するために必要な基礎知識　臨床医が知っておきたいSARS-CoV-2の基礎, 神谷 亘, Jan. 2021, 別冊, 14
• 【感染免疫の分子制御メカニズム】コロナウイルス(SARS-CoV、SARS-CoV-2、MERS-CoV)に対する感染防御機構とウイルス逃避, 神谷 亘, Feb. 2021, 29, 2, 104
• COVID-19の基礎から臨床まで　コロナウイルスとは?, 神谷 亘, Feb. 2021, 125, 2, 174
• コロナウイルスと免疫細胞のクロストーク, 神谷 亘, Mar. 2021, 2020年度, 102
• 小児におけるCOVID-19　SARS-CoV-2の微生物学的特徴, 神谷 亘, Oct. 2021, 53回, 79
• SARS-CoV-2の感染・病態におけるウイルス-宿主間相互作用　SARS-CoV-2の非構造蛋白質1と宿主相互作用の解明, 神谷 亘, Nov. 2021, 94回, [1S10e
• マクロ孔型の多孔質炭素は、腸管出血性大腸菌の病原性を抑制する, ;;;;, Feb. 2022, 77, 1, 90
• 【ウイルス感染症の克服に向けた新展開】SARS、MERS、そしてSARS-CoV-2の制圧に向けて, 神谷 亘, May 2022, 54, 5, 234
• 新型コロナウィルス流行下でのヒトと動物の暮らし　COVID研究の現状と展望, 神谷 亘, Sep. 2021, 164回, [V2
• SARS-CoV-2の感染・病態におけるウイルス-宿主間相互作用　SARS-CoV-2の非構造蛋白質1と宿主相互作用の解明, 神谷 亘, Nov. 2021, 94回, [1S10e
• マクロ孔型の多孔質炭素は、腸管出血性大腸菌の病原性を抑制する, ;;;;, Feb. 2022, 77, 1, 90
• 新型コロナウィルス流行下でのヒトと動物の暮らし　COVID研究の現状と展望, 神谷 亘, Sep. 2021, 164回, [V2
• 【ウイルス感染症の克服に向けた新展開】SARS、MERS、そしてSARS-CoV-2の制圧に向けて, 神谷 亘, May 2022, 54, 5, 234
• 【日々変化する新型コロナウイルス感染症とその管理】新型コロナウイルスの変異株について, 神谷 亘, May 2022, 46, 5, 265
• SARSコロナウイルス2の分子生物学的特徴について, 神谷 亘, Jun. 2022, 70回, np56
• Neutralizing and binding activities against SARS-CoV-1/2, MERS-CoV, and human coronaviruses 229E and OC43 by normal human intravenous immunoglobulin derived from healthy donors in Japan, Kubota-Koketsu, Ritsuko;Terada, Yutaka;Yunoki, Mikihiro;Sasaki, Tadahiro;Nakayama, Emi E.;Kamitani, Wataru;Shioda, Tatsuo, 2021, TRANSFUSION, 61, 2, 356, 360

  DOI
• Blood-cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA, Ha Ngo-Thanh;Sasaki, Tsutomu;Suzue, Kazutomo;Yokoo, Hideaki;Isoda, Koji;Kamitani, Wataru;Shimokawa, Chikako;Hisaeda, Hajime;Imai, Takashi, 2020, INTERNATIONAL JOURNAL FOR PARASITOLOGY, 50, 14, 1167, 1175

  DOI
• The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells, Matsuyama, Shutoku;Kawase, Miyuki;Nao, Naganori;Shirato, Kazuya;Ujike, Makoto;Kamitani, Wataru;Shimojima, Masayuki;Fukushi, Shuetsu, 2021, JOURNAL OF VIROLOGY, 95, 1

  DOI
• Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth, Ujike, Makoto;Kawachi, Yukako;Matsunaga, Yui;Etho, Yuka;Asanuma, Hideki;Kamitani, Wataru;Taguchi, Fumihiro, 2021, JOURNAL OF VIROLOGY, 95, 3

  DOI
• The long-quarantined case of COVID-19 with prolonged viral shedding and intermittent fever for more than 70 days, Yamada, Eijiro;Ishida, Emi;Nakajima, Yasuyo;Horiguchi, Kazuhiko;Matsumoto, Shunichi;Okada, Shuichi;Kamitani, Wataru;Yamada, Masanobu, 2021, FUTURE VIROLOGY, 16, 2, 79, 84

  DOI
• Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction, Torii, Shiho;Ono, Chikako;Suzuki, Rigel;Morioka, Yuhei;Anzai, Itsuki;Fauzyah, Yuzy;Maeda, Yusuke;Kamitani, Wataru;Fukuhara, Takasuke;Matsuura, Yoshiharu, 2021, CELL REPORTS, 35, 3

  DOI
• Long-term acrylamide exposure exacerbates brain and lung pathology in a mouse malaria model, Ha Ngo-Thanh;Trang Dam Thuy;Suzue, Kazutomo;Kamitani, Wataru;Yokoo, Hideaki;Isoda, Koji;Shimokawa, Chikako;Hisaeda, Hajime;Imai, Takashi, 2021, FOOD AND CHEMICAL TOXICOLOGY, 151

  DOI
• Adsorption of Phenazines Produced by Pseudomonas aeruginosa Using AST-120 Decreases Pyocyanin-Associated Cytotoxicity, Hirakawa, Hidetada;Takita, Ayako;Uchida, Motoyuki;Kaneko, Yuka;Kakishima, Yuto;Tanimoto, Koichi;Kamitani, Wataru;Tomita, Haruyoshi, 2021, ANTIBIOTICS-BASEL, 10, 4

  DOI
• Roles of OmpX, an Outer Membrane Protein, on Virulence and Flagellar Expression in Uropathogenic Escherichia coli, Hirakawa, Hidetada;Suzue, Kazutomo;Takita, Ayako;Kamitani, Wataru;Tomita, Haruyoshi, 2021, INFECTION AND IMMUNITY, 89, 6

  DOI
• Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection, Taniguchi, Masateru;Minami, Shohei;Ono, Chikako;Hamajima, Rina;Morimura, Ayumi;Hamaguchi, Shigeto;Akeda, Yukihiro;Kanai, Yuta;Kobayashi, Takeshi;Kamitani, Wataru;Terada, Yutaka;Suzuki, Koichiro;Hatori, Nobuaki;Yamagishi, Yoshiaki;Washizu, Nobuei;Takei, Hiroyasu;Sakamoto, Osamu;Naono, Norihiko;Tatematsu, Kenji;Washio, Takashi;Matsuura, Yoshiharu;Tomono, Kazunori, 2021, NATURE COMMUNICATIONS, 12, 1

  DOI
• COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions, Urano, Emiko;Okamura, Tomotaka;Ono, Chikako;Ueno, Shiori;Nagata, Satoshi;Kamada, Haruhiko;Higuchi, Mahoko;Furukawa, Mugi;Kamitani, Wataru;Matsuura, Yoshiharu;Kawaoka, Yoshihiro;Yasutomi, Yasuhiro, 2021, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118, 43

  DOI
• ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury, Yamaguchi, Tomokazu;Hoshizaki, Midori;Minato, Takafumi;Nirasawa, Satoru;Asaka, Masamitsu N.;Niiyama, Mayumi;Imai, Masaki;Uda, Akihiko;Chan, Jasper Fuk-Woo;Takahashi, Saori;An, Jianbo;Saku, Akari;Nukiwa, Ryota;Utsumi, Daichi;Kiso, Maki;Yasuhara, Atsuhiro;Poon, Vincent Kwok-Man;Chan, Chris Chung-Sing;Fujino, Yuji;Motoyama, Satoru;Nagata, Satoshi;Penninger, Josef M.;Kamada, Haruhiko;Yuen, Kwok-Yung;Kamitani, Wataru;Maeda, Ken;Kawaoka, Yoshihiro;Yasutomi, Yasuhiro;Imai, Yumiko;Kuba, Keiji, 2021, NATURE COMMUNICATIONS, 12, 1

  DOI
• Reverse Genetics with a Full-Length Infectious cDNA Clone of Bovine Torovirus, Ujike, Makoto;Etoh, Yuka;Urushiyama, Naoya;Taguchi, Fumihiro;Asanuma, Hideki;Enjuanes, Luis;Kamitani, Wataru, 2022, JOURNAL OF VIROLOGY, 96, 3
• 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents, Konno, Sho;Kobayashi, Kiyotaka;Senda, Miki;Funai, Yuta;Seki, Yuta;Tamai, Ikumi;Schaekel, Laura;Sakata, Kyousuke;Pillaiyar, Thanigaimalai;Taguchi, Akihiro;Taniguchi, Atsuhiko;Guetschow, Michael;Mueller, Christa E.;Takeuchi, Koh;Hirohama, Mikako;Kawaguchi, Atsushi;Kojima, Masaki;Senda, Toshiya;Shirasaka, Yoshiyuki;Kamitani, Wataru;Hayashi, Yoshio, 2022, JOURNAL OF MEDICINAL CHEMISTRY, 65, 4, 2926, 2939

  DOI
• A Macroporous Magnesium Oxide-Templated Carbon Adsorbs Shiga Toxins and Type III Secretory Proteins in Enterohemorrhagic Escherichia coli, Which Attenuates Virulence, Hirakawa, Hidetada;Suzue, Kazutomo;Uchida, Motoyuki;Takita, Ayako;Kamitani, Wataru;Tomita, Haruyoshi, 2022, FRONTIERS IN MICROBIOLOGY, 13

  DOI
• Vaccine Topics Q&A　新型コロナウイルス感染症の感染防御対策について教えてください, 神谷 亘, Sep. 2020, 8, Suppl.1, 20
• 人と動物のコロナウイルス　COVID-19　SARS-CoV-2に関する最新知見, 神谷 亘, Oct. 2020, 163回, 128
• Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication, Shiori Ueno; Sodbayasgalan Amarbayasgalan; Yoshiro Sugiura; Tatsuki Takahashi; Kenta Shimizu; Keisuke Nakagawa; Reika Kawabata-Iwakawa; Wataru Kamitani, Jul. 2024, Virology, 595, 110068, 110068, Scientific journal

  DOI
• Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II., Tatsuki Takahashi; Shiori Ueno; Yoshiro Sugiura; Kenta Shimizu; Wataru Kamitani, 09 Jul. 2023, Microbiology and immunology, Scientific journal

  DOI

MISC

• ダニ媒介性脳炎ウイルスの3'非翻訳領域に関わる宿主因子の検索, 武藤 芽未; 神谷 亘; 境 瑞紀; 平野 港; 小林 進太郎; 苅和 宏明; 好井 健太朗, Aug. 2017, 160回, 411, 411
• ダニ媒介性脳炎ウイルス由来非コードRNAと相互作用するマダニ宿主蛋白質の同定及び機能解析, 西山 祥子; 平野 港; 武藤 芽未; 小林 進太郎; 神谷 亘; 苅和 宏明; 好井 健太朗, Aug. 2019, 162回, 421, 421
• 国内猫及び犬コロナウイルスの全塩基配列の決定, 黒田 雄大; 寺田 豊; 神先 芽衣; 立本 完吾; Supriyono Supriyono; Ngo Thi Bao Tran; 南 昌平; 米満 研三; 鍬田 龍星; 下田 宙; 神谷 亘; 前田 健, Aug. 2018, 日本獣医学会学術集会講演要旨集, 161回, 348, 348
• 高FIP起病性を有するI型FCoV株を用いた逆遺伝子操作系の作出, 寺田 豊; 黒田 雄大; 前田 健; 神谷 亘, Aug. 2018, 日本獣医学会学術集会講演要旨集, 161回, 367, 367
• Therapeutic effects of angiotensin converting enzyme 2 (ACE2) enzyme activity on acute lung injury in COVID-19, Tomokazu Yamaguchi; Midori Hoshizaki; Takafumi Minato; Satoru Nirasawa; Masamitsu Asaka; Mayumi Niiyama; Jianbo An; Daichi Utsumi; Satoshi Nagata; Haruhiko Kamada; Wataru Kamitani; Yoshihiro Kawaoka; Yasuhiro Yasutomi; Yumiko Imai; Keiji Kuba, 2022, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95, 2, O

  DOI
• SARS-CoV-2の新規リバースジェネティクス法の確立, 鳥居志保; 小野慎子; 鈴木理滋; 森岡佑平; 安齋樹; FAUZYAH Yuzy; 前田裕輔; 神谷亘; 福原崇介; 福原崇介; 松浦善治, 2020, 43rd
• コウモリ由来細胞におけるSARSコロナウイルスnsp1タンパク質のshutoff能の比較, 神谷亘; 坂井祐介; 前田健; 松浦善治, 2014, 62nd

Presentations

• コロナウイルスとの共存と 脱却に向けてウイルス学的に考える, 神谷亘, 高崎健康福祉大学FD, 03 Feb. 2023, Japanese
• Identification of a kinase inhibitor with inhibitory effect on intracellular replication of SARS-CoV-2, 清水健太、上野栞、鈴木理滋、津田祥美、高橋龍樹、杉浦嘉郎、神谷亘、福原崇介, 第６９回日本ウイルス学会学術集会, 14 Nov. 2022
• HiBiT発現ヒト RSウイルスの確立, 高橋 龍樹、上野 栞、杉浦 嘉郎、清水 健太、神谷 亘, 第６９回日本ウイルス学会学術集会, 13 Nov. 2022
• SARS-CoV-2の nsp1-HiBiT組換えウイルスの作出の試み, 上野 栞、高橋 龍樹、清水 健太、杉浦 嘉郎、神谷 亘, 第６９回日本ウイルス学会学術集会, 13 Nov. 2022
• SARS-CoV-2 nsp1のN末端側８アミノ酸残基欠損の病原性への影響, 上野栞、高橋龍樹、清水健太、杉浦嘉郎、神谷亘, 第69回北関東医学会総会, 29 Sep. 2022
• コロナウイルスの分子生物学的特徴について, 神谷亘, 化学工学会第53回秋季大会, 16 Sep. 2022, Japanese
• コロナウイルスの特性と 複製と 病原性, 神谷亘, 神奈川県衛生研究所 学術講演会 令和4年度第1回公衆衛生専門技術研修, 14 Sep. 2022, Japanese
• 人獣共通感染症としてのコロナウイルス, 神谷亘, 令和４年度宮崎大学大学院特別セミナー, 29 Jul. 2022, Japanese
• SARSコロナウイルス2と その遺伝子組換え, 神谷亘, 第14回 遺伝子組換え実験安全研修会, 23 Jul. 2022, Japanese
• COVID-19の現状と展望, 神谷亘, 刀城クラブ, 13 Jul. 2022, Japanese
• 新型コロナウイルスを含む コロナウイルスの遺伝子操作系とコロナウイルスの複製, 神谷亘, 第35回インフルエンザ研究者交流の会シンポジウム, 08 Jul. 2022, Japanese
• 新興βコロナウイルス感染症としてのCOVID-19とSARS-CoV-2 の複製機構の解析, 神谷亘, 第55回日本ウイルス学会北海道支部シンポジウム, 02 Jul. 2022, Japanese
• コロナウイルスを読み解く, 神谷亘, 明寿大学「講座」, 20 Jun. 2022, Japanese
• SARSコロナウイルス２の分子生物学的特徴について, 神谷亘, 第70回日本消化器病学会甲信越支部例会, 18 Jun. 2022
• 「コロナウイルスの基礎と今後について考える」, 神谷亘, 群馬市民大学「講座」, 09 Jun. 2022, Japanese
• SARS-CoV-2 Up to date  ～ウイルス基礎から戦略を考える～, 神谷亘, 第96回 日本感染症学会総会・学術講演会 共催セミナー, 22 Apr. 2022, Japanese
• コロナウイルスの増殖と病気について, 神谷亘, 第17回霊長類医科学フォーラム 「市民公開講座」, Nov. 2021
• コロナウイルスの非構造蛋白質による複製制御, 神谷亘, "第68回日本ウイルス学会学術集会　シンポジウム3「SARS-CoV-2（新型コロナウイルス）」 ", 17 Nov. 2021
• COVID-19を読み解く, 神谷亘, 群馬医療福祉大学「公開講座」, 06 Nov. 2021
• SARS-CoV-2の非構造蛋白質1と宿主相互作用の解明, 神谷亘, 第94回日本生化学会大会シンポジウムSARS-CoV-2の感染・病態におけるウイルス-宿主間相互作用, 03 Nov. 2021
• COVID-19の発生から今日までを振り返る～研究者の視点から～, 神谷亘, 第21回 人と動物の共通感染症研究会学術集会, 23 Oct. 2021
• SARS-CoV-2の生物学的特徴, 神谷亘, 第53回日本小児科学会学術集会シンポジウム小児におけるCOVID-19, 09 Oct. 2021
• Emerging and Re-emerging Coronaviruses in humans and animals, 神谷亘, 第9回SaSSOH, 16 Sep. 2021
• COVID研究の現状と展望, 神谷亘, 第164回日本獣医学会学術集会司宰機関企画市民公開講座１, 07 Sep. 2021
• コロナウイルスの基礎から新型コロナウイルスの今後について, 神谷亘, 令和３年度 群馬県感染症予防・対策研修会, 05 Jul. 2021
• コロナウイルスの分子生物学的特徴と複製機構, 神谷亘, 2021年生化学会関東支部例会, 19 Jun. 2021
• コロナウイルスに関する講演, 神谷亘, 第68回日本実験動物学会総会, 19 May 2021, Japanese
• MERS SARSについて, 神谷亘, 福岡県”One Health"国際フォーラム2021, 30 Jan. 2021, 30 Jan. 2021, 30 Jan. 2021, Japanese, Domestic conference
• コロナウイルスを上毛野国で考える-どうしてコロナウイルスなのか-, 神谷亘, ウイルス学若手研究集会2020, 18 Dec. 2020, 18 Dec. 2020, 18 Dec. 2020, Japanese, Domestic conference
• 霊長類医科学フォーラム　COVID-19に関する基礎ウイルス学的特徴について, 神谷亘, 第16回霊長類医科学フォーラム, 17 Nov. 2020, 17 Nov. 2020, 17 Nov. 2020, Japanese, Japan, Domestic conference
• 日本学術会議　公開シンポジウム, 神谷亘, 日本学術会議・人と動物の共通感染症研究会　公開シンポジウム, 14 Nov. 2020, 14 Nov. 2020, 14 Nov. 2020, Japanese, Domestic conference
• 日本学術会議北海道地区会議学術講演　コロナウイルス感染症, 神谷亘, 日本学術会議北海道地区会議学術講演, 07 Nov. 2020, 07 Nov. 2020, 07 Nov. 2020, Japanese, Domestic conference
• SARS,MERS, COVID-19, 神谷亘, 第20回人と動物の共通感染症研究会学術集会, 24 Oct. 2020, 24 Oct. 2020, 24 Oct. 2020, Japanese, Domestic conference
• MiUワークショップ　新型コロナウイルスに関するウイルス学的情報, 神谷亘, 埼玉大学先端産業国際ラボラトリー第13回ワークショップ, 14 Sep. 2020, 14 Sep. 2020, 14 Sep. 2020, Japanese, Domestic conference
• COVID-19：SARS-CoV-2に関する最新知見, 神谷亘, 第163回日本獣医学会学術集会, 08 Sep. 2020, 08 Sep. 2020, 10 Sep. 2020, Japanese, Domestic conference
• コロナウイルスってどんなウイルス？, 神谷亘, 第124回日本小児科学学術集会, 17 Apr. 2021, 16 Apr. 2021, 18 Apr. 2021, Japanese, Domestic conference
• MERS SARSについて, 神谷亘, 福岡県”One Health"国際フォーラム2021, 30 Jan. 2021, 30 Jan. 2021, 30 Jan. 2021, Japanese, Domestic conference
• 霊長類医科学フォーラム COVID-19に関する基礎ウイルス学的特徴について, 神谷亘, 第16回霊長類医科学フォーラム, 17 Nov. 2020, 17 Nov. 2020, 17 Nov. 2020, Japanese, Domestic conference
• 日本学術会議 公開シンポジウム, 神谷亘, 日本学術会議・人と動物の共通感染症研究会 公開シンポジウム, 14 Nov. 2020, 14 Nov. 2020, 14 Nov. 2020, Japanese, Domestic conference
• 日本学術会議北海道地区会議学術講演 コロナウイルス感染症, 神谷亘, 日本学術会議北海道地区会議学術講演, 07 Nov. 2020, 07 Nov. 2020, 07 Nov. 2020, Japanese, Domestic conference
• SARS,MERS, COVID-19, 神谷亘, 第20回人と動物の共通感染症研究会学術集会, 24 Oct. 2020, 24 Oct. 2020, 24 Oct. 2020, Japanese, Domestic conference
• MiUワークショップ 新型コロナウイルスに関するウイルス学的情報, 神谷亘, 埼玉大学先端産業国際ラボラトリー第13回ワークショップ, 14 Sep. 2020, 14 Sep. 2020, 14 Sep. 2020, Japanese, Domestic conference
• COVID-19：SARS-CoV-2に関する最新知見, 神谷亘, 第163回日本獣医学会学術集会, 08 Sep. 2020, 08 Sep. 2020, 10 Sep. 2020, Japanese, Domestic conference

Industrial Property Rights

• Patent right

Research Projects

• Application of reverse genetics system of MERS coronavirus, Kamitani Wataru, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2016, 31 Mar. 2019, Middle East respiratory syndrome (MERD) coronavirus emerged in Saudi Arabia. MERS coronavirus is lethal human coronavirus still endemic in the Arabian Peninsula. In this study, we established a reverse genetic system for MERS coronavirus using a BAC system. We studied the effect of nonstructural protein 1 (nsp1) on viral replication using the reverse genetics system. We found that MERS coronavirus nsp1 bound to viral genomic RNA. We revealed that the specific binding of nsp1 with viral genomic RNA was critical for the efficient replication of MERS coronavirus. Our data indicated that the specific binding is new target for development of novel antivirals against MERS coronavirus., 16K08811

  対象リソースIRI
• Understanding of viral replication through the interaction with coronavirus nsp1 and host proteins, WATARU KAMITANI, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Osaka University, 01 Apr. 2012, 31 Mar. 2014, Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a newly emerged disease. Nsp1 binds to 40S ribosome subunits, which causes a translational shutoff in the cells expressing nsp1. The nsp1-40S complex further induces an endonucleolytic RNA cleavage near the 5'UTR of host mRNA, resulting in the promotion of RNA decay. However, the mechanism by which nsp1-induced RNA cleavage is unknown. We identified Upf1 as a binding partner of nsp1 by pulldown purification and mass spectrometry. Upf1 is a predominantly cytoplasmic RNA-binding protein that is essential for nonsense-mediated RNA decay pathway. Coimmunoprecipitation analyses in transfected cells confirmed a specific interaction between nsp1 and Upf1. Small interfering RNA-mediated knockdown of Upf1 resulted in suppression of nsp1-mediated RNA cleavage. Our data indicate a novel mechanism of host mRNA cleavage by SARA-CoV nsp1 protein., 24790439

  対象リソースIRI
• Circumvention of RNA decay in cells infected with SARS coronavirus, KAMITANI Wataru, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Osaka University, 2010, 2011, SARS coronavirus nsp1 protein was shown to suppress host protein syntheses through the degradation of mRNA and the binding to 40S ribosomal subunits. However, SCoV is capable of replicating well in cells impaired the host protein syntheses by the expression of nsp1. To determine the mechanism of an efficient translation of mRNA of SCoV in cells expressing the nsp1, we investigated the effect of the UTRs of SCoV on the evasion from the nsp1-mediated translational suppression. We generated the reporter plasmids carrying a firefly luciferase gene flanked by the 5' UTR and/ or 3' UTR of SCoV and determined the luciferase activity in cells expressing the nsp1. Suppression of luciferase activity by the expression of nsp1 was cancelled by the transfection of the reporter plasmids carrying the 5' UTR of SCoV but not by those possessing the 3' UTR. Protein-RNA binding assay revealed that the positively charged region in the nsp1 responsible for a specific interaction with the stem-loop1 in the 5' UTR., 22790431

  対象リソースIRI
• 2009, 2010, 21890126

  対象リソースIRI
• 01 Apr. 2022, 31 Mar. 2025, 22K06073

  対象リソースIRI

Social Contribution

Social Contribution

• プロフェッサービジット, 17 Mar. 2021, 17 Mar. 2021　(Target:　High school students)
• 群馬大学地域貢献シンポジウム　「新型コロナウイルスの基礎知識」, 23 Feb. 2021, 23 Feb. 2021, Lecture　(Target:　General)
• 2021次世代センサ総合シンポジウム　コロナウイルスの基礎ウイルス学的情報, 17 Feb. 2021, 19 Feb. 2021, Lecture　(Target:　Researchers, General)
• コロナ禍における図書館運営　新型コロナウイルスについて, 26 Nov. 2020, Lecture　(Target:　General)
• 霊長類医科学フォーラム　市民公開講座　, 17 Nov. 2020, 17 Nov. 2020, Lecture　(Target:　Researchers, General)
• ウィズ・コロナにおいて伝えたいこと, 15 Oct. 2020, 15 Oct. 2020, Lecture　(Target:　General)
• ナレッジキャピタル　「コロナウイルスを知る」, 06 Jun. 2020, 06 Jun. 2020　(Target:　General)
• プロフェッサービジット, 17 Mar. 2021, 17 Mar. 2021
• 群馬大学地域貢献シンポジウム 「新型コロナウイルスの基礎知識」, 23 Feb. 2021, 23 Feb. 2021
• 2021次世代センサ総合シンポジウム コロナウイルスの基礎ウイルス学的情報, 17 Feb. 2021, 19 Feb. 2021
• コロナ禍における図書館運営 新型コロナウイルスについて, 26 Nov. 2020
• 霊長類医科学フォーラム 市民公開講座, 17 Nov. 2020, 17 Nov. 2020
• ウィズ・コロナにおいて伝えたいこと, 15 Oct. 2020, 15 Oct. 2020
• ナレッジキャピタル 「コロナウイルスを知る」, 06 Jun. 2020, 06 Jun. 2020

Media Coverage

• プロフェッサービジットの広告掲載, 28 Sep. 2020