Researcher Profile and Settings

Researcher

• Name

  NAKAGAWA Yuuko

Affiliation

• Institute for Molecular and Cellular Regulation, Assistant Professor

Profile and Settings

• Name

  Nakagawa, Yuuko

Affiliation

• Gunma University
• Gunma University

Affiliation

• Affiliation

  Institute for Molecular and Cellular Regulation

• Job title

  Assistant Professor

Research Experience

• Gunma University, Research Assistant, Assistant prof lv

Research Activities

Research Areas

• Life sciences, Physiology
• Life sciences, Clinical pharmacy

Research Interests

• GPCR cAMP calcium DAG DM

Published Papers

• Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model, Ayako Fukunaka, Mari Shimura , Takayuki Ichinose , Ofejiro B Pereye , Yuko Nakagawa , Yasuko Tamura , Wakana Mizutani , Ryota Inoue , Takato Inoue , Yuto Tanaka , Takashi Sato , Tatsuya Saitoh , Toshiyuki Fukada , Yuya Nishida , Takeshi Miyatsuka , Jun Shirakawa , Hirotaka Watada , Satoshi Matsuyama , Yoshio Fujitani, 15 Mar. 2023, Sci Rep ., 13, 1
• Establishment of an enzyme-linked immunosorbent assay for mouse pancreatic polypeptide clarifies the regulatory mechanism of its secretion from pancreatic γ cells, Daisuke Saito, Yuko Nakagawa , Takashi Sato , Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama , Hirotaka Watada , Yoshio Fujitani, 17 Aug. 2022, PLoS One, 17, 8, e0269958
• Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice, Takahiro Fukaishi , Yuko Nakagawa, Ayako Fukunaka , Takashi Sato, Akemi Hara, Keiko Nakao , Michiko Saito , Kenji Kohno , Takeshi Miyatsuka, Motoyuki Tamaki 8 , Munehide Matsuhisa, Taka-Aki Matsuoka , Tetsuya Yamada , Hirotaka Watada , Yoshio Fujitani, 06 Dec. 2021, Diabetologia ., 64, 12, 2803, 2816
• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice, Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Noriyasu Ohshima, Chinatsu Saito, Wakana Iwasaki, Yuko Nakagawa, Yoshio Fujitani, Ryo Yoshida, Yoshifumi Saito 1 , Takashi Izumi, Shin-Ichi Terawaki, Masakiyo Sakaguchi, Frank J Gonzalez , Yusuke Inoue, 26 Apr. 2023, J Biochem ., 173, 5, 393, 411
• Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide, Akemi Hara, Yuko Nakagawa, Keiko Nakao, Motoyuki Tamaki, Tetsuya Ikemoto, Mitsuo Shimada , Munehide Matsuhisa, Hiroki Mizukami , Nobuhiro Maruyama , Hirotaka Watada , Yoshio Fujitani, 28 May 2019, Endocr J ., 66, 5, 459, 468
• Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic beta-Cells, Yuko Nakagawa; Masahiro Nagasawa; Johan Medina; Itaru Kojima, Dec. 2015, PLOS ONE, 10, 12, Scientific journal

  DOI
• Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic beta-cells, Kunihisa Hamano; Yuko Nakagawa; Yoshiaki Ohtsu; Longfei Li; Johan Medina; Yuji Tanaka; Katsuyoshi Masuda; Mitsuhisa Komatsu; Itaru Kojima, Jul. 2015, JOURNAL OF ENDOCRINOLOGY, 226, 1, 57, 66, Scientific journal

  DOI
• Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic beta-cells, Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Kunihisa Hamano; Johan Medina; Masahiro Nagasawa, May 2015, Journal of Diabetes Investigation, 6, 3, 256, 263

  DOI
• Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose, Johan Medina; Yuko Nakagawa; Masahiro Nagasawa; Anny Fernandez; Kazushige Sakaguchi; Tetsuya Kitaguchi; Itaru Kojima, Oct. 2016, JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 44, 23126, 23135, Scientific journal

  DOI
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells, Yoshiaki Ohtsu; Yuko Nakagawa; Masahiro Nagasawa; Shigeki Takeda; Hirokazu Arakawa; Itaru Kojima, Aug. 2014, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 394, 1-2, 70, 79, Scientific journal

  DOI
• Role of the glucose-sensing receptor in insulin secretion, Itaru Kojima; Johan Medina; Yuko Nakagawa, Sep. 2017, DIABETES OBESITY & METABOLISM, 19, 1, 54, 62

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137, Scientific journal

  DOI
• T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells, Yosuke Masubuchi; Yuko Nakagawa; Johan Medina; Masahiro Nagasawa; Itaru Kojima; Mark M. Rasenick; Takeshi Inagaki; Hiroshi Shibata, May 2017, PLOS ONE, 12, 5, Scientific journal

  DOI
• A mechanosensitive anion channel in Arabidopsis thaliana mesophyll cells, Z Qi; A Kishigami; Y Nakagawa; H Iida; M Sokabe, Nov. 2004, PLANT AND CELL PHYSIOLOGY, 45, 11, 1704, 1708, Scientific journal
• Arabidopsis plasma membrane protein crucial for Ca2+ influx and touch sensing in roots, Yuko Nakagawa; Takeshi Katagiri; Kazuo Shinozaki; Zhi Qi; Hitoshi Tatsumi; Takuya Furuichi; Akio Kishigami; Masahiro Sokabe; Itaru Kojima; Shusei Sato; Tomohiko Kato; Satoshi Tabata; Kazuko Iida; Asuka Terashima; Masataka Nakano; Mitsunobu Ikeda; Takuya Yamanaka; Hidetoshi Iida, Feb. 2007, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 9, 3639, 3644, Scientific journal

  DOI
• Sweet Taste Receptor Expressed in Pancreatic beta-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion, Yuko Nakagawa; Masahiro Nagasawa; Satoko Yamada; Akemi Hara; Hideo Mogami; Viacheslav O. Nikolaev; Martin J. Lohse; Noriatsu Shigemura; Yuzo Ninomiya; Itaru Kojima, Apr. 2009, PLOS ONE, 4, 4, Scientific journal

  DOI
• MCA1 and MCA2 that mediate Ca2+ uptake have distinct and overlapping roles in Arabidopsis., Yamanaka T; Nakagawa Y; Mori K; Nakano M; Imamura T; Kataoka H; Terashima A; Iida K; Kojima I; Katagiri T; Shinozaki K; Iida H, Jan. 2010, 152, 3
• The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells., Oct. 2011, Diabetes Metab J., 35
• Interferon Regulatory Factor-2 Regulates Exocytosis Mechanisms Mediated by SNAREs in Pancreatic Acinar Cells, Hirosato Mashima; Taku Sato; Yasuo Horie; Yuko Nakagawa; Itaru Kojima; Toshiaki Ohteki; Hirohide Ohnishi, Sep. 2011, GASTROENTEROLOGY, 141, 3, 1102, U459, Scientific journal

  DOI
• Plasma membrane protein OsMCA1 is involved in regulation of hypo-osmotic shock-induced Ca2+ influx and modulates generation of reactive oxygen species in cultured rice cells, Takamitsu Kurusu; Daisuke Nishikawa; Yukari Yamazaki; Mariko Gotoh; Masataka Nakano; Haruyasu Hamada; Takuya Yamanaka; Kazuko Iida; Yuko Nakagawa; Hikaru Saji; Kazuo Shinozaki; Hidetoshi Iida; Kazuyuki Kuchitsu, Jan. 2012, BMC PLANT BIOLOGY, 12, Scientific journal

  DOI
• Function of sweet taste receptor in pancreatic β-cells, Yuko Nakagawa, 2011, Seikagaku, 83, 7, 647, 651, Scientific journal
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Tsutomu Sasaki; Mayumi Shimpuku; Tomoya Kitazumi; Haruna Hiraga; Yuko Nakagawa; Hiroshi Shibata; Yuko Okamatsu-Ogura; Osamu Kikuchi; Hye-Jin Kim; Yuki Fujita; Jun Maruyama; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Masayuki Saito; Tadahiro Kitamura, 2013, Endocrine Journal, 60, 10, 1117, 1129, Scientific journal

  DOI
• Multimodal function of the sweet taste receptor expressed in pancreatic beta-cells: generation of diverse patterns of intracellular signals by sweet agonists, Yuko Nakagawa; Masahiro Nagasawa; Hideo Mogami; Martin Lohse; Yuzo Ninomiya; Itaru Kojima, Oct. 2013, ENDOCRINE JOURNAL, 60, 10, 1191, 1206, Scientific journal
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells, Yosuke Masubuchi; Yuko Nakagawa; Jinhui Ma; Tsutomu Sasaki; Tadahiro Kitamura; Yoritsuna Yamamoto; Hitoshi Kurose; Itaru Kojima; Hiroshi Shibata, 15 Jan. 2013, PLoS ONE, 8, 1, Scientific journal

  DOI
• Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states, Anya Medina; Yuko Nakagawa; Jinhui Ma; Longfei Li; Kunihisa Hamano; Toshio Akimoto; Yuzo Ninomiya; Itaru Kojima, Aug. 2014, ENDOCRINE JOURNAL, 61, 8, 797, 805, Scientific journal

  DOI
• Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists., Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Anya Medina; Masahiro Nagasawa, Mar. 2014, Endocrinology and metabolism (Seoul, Korea), 29, 1, 12, 9, Scientific journal

  DOI
• Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3, Yuko Nakagawa; Yoshiaki Ohtsu; Masahiro Nagasawa; Hiroshi Shibata; Itaru Kojima, Feb. 2014, ENDOCRINE JOURNAL, 61, 2, 119, 131, Scientific journal

  DOI
• Prolonged Insulin Stimulation Down-regulates GLUT4 through Oxidative Stress-mediated Retromer Inhibition by a Protein Kinase CK2-dependent Mechanism in 3T3-L1 Adipocytes, Ma, Jinhui; Nakagawa, Yuko; Kojima, Itaru; Shibata, Hiroshi, Jan. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 1

  DOI
• Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic beta-Cells, Itaru Kojima; Yuko Nakagawa; Kunihisa Hamano; Johan Medina; Longfei Li; Masahiro Nagasawa, May 2015, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38, 5, 674, 679, Scientific journal

  DOI
• Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms, Longfei Li; Yoshiaki Ohtsu; Yuko Nakagawa; Katsuyoshi Masuda; Itaru Kojima, Aug. 2016, ENDOCRINE JOURNAL, 63, 8, 715, 725, Scientific journal
• Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide, Akemi Hara; Yuko Nakagawa; Keiko Nakao; Motoyuki Tamaki; Tetsuya Ikemoto; Mitsuo Shimada; Munehide Matsuhisa; Hiroki Mizukami; Nobuhiro Maruyama; Hirotaka Watada; Yoshio Fujitani, 2019, Endocrine Journal, 66, 5, 459, 468, Scientific journal

  DOI
• グルコース感知受容体を介する代謝促進機構, 李 龍飛; 中川 祐子; 大津 義晃; 小島 至, Apr. 2016, 59, Suppl.1, S, 354
• ラクチゾールは膵β細胞のグルコース感知受容体T1R3を抑制する, 濱野 邦久; 中川 祐子; 李 龍飛; 大津 義晃; 田中 佑司; 小島 至, Apr. 2014, 57, Suppl.1, S, 323
• 膵β細胞におけるグルコース感知受容体T1R3の発現変化, 中川 祐子; Anya Medina; 濱野 邦久; 大津 義晃; 李 龍飛; 馬 金輝; 小島 至, Apr. 2014, 57, Suppl.1, S, 404
• [Ca2+ channels in plants]., Iida H; Kishigami A; Tada T; Nakagawa Y; Yamanaka T, Nov. 2003, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
• Pancreatic cancer model using PpyCre mediated-oncogene activation(和訳中), ;;;;;, Jun. 2022, 84, 2, 128
• 悪性転化における遺伝的に誘導されたPpy発現細胞の不死化(Genetically induced immortalization of Ppy-expressing cells results in malignant transformation), ;;;;;, Apr. 2022, 98, 1, 294
• マウス膵島が産生するGABAの主要合成酵素の解明, ;;;;;, Aug. 2021, 71, 3, 257
• Ppy遺伝子の活性化がβ細胞のheterogeneityを規定する, ;;;;;;;;, May 2021, 64, Suppl.1, RP1
• GIPはPP分泌を促進する　新規PP ELISA系を用いた解析, ;;;;;;;;, Apr. 2021, 97, 1, 287
• 内分泌前駆細胞としてのPpy lineage cellの解析, ;;;;;;;;, Aug. 2020, 63, Suppl.1, S
• 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPP細胞の解析, ;;;;;;;;, Feb. 2020, 82, 1, 46
• グルコース感知受容体を介する代謝促進機構の解明, ;;;;;, Apr. 2018, 61, Suppl.1, S
• グルコース感知受容体の分子実体の解明　CaSRノックアウト細胞を用いた検討, ;;;, Aug. 2017, 67, 3, 271
• T1R3ホモダイマーの機能解析, ;;, Apr. 2017, 60, Suppl.1, S
• Function of sweet taste receptor in pancreatic β-cells, NAKAGAWA Yuko, Jul. 2011, 83, 7, 647, 651
• 【GPCR研究の最前線2016】GPCR機能の新展開【内分泌】グルコース感知受容体によるインスリン分泌の制御, ;, Jan. 2016, 256, 5, 514
• インスリンによる過酸化水素産生亢進におけるペルオキシレドキシン1の役割, ;;, Apr. 2016, 59, Suppl.1, S
• グルコース感知受容体を介する代謝促進機構, ;;;, Apr. 2016, 59, Suppl.1, S
• T1R3/CaSRヘテロダイマーはグルコース感知受容体として機能する, ;;, Apr. 2016, 59, Suppl.1, S
• グルコースによるカルシウム感知受容体の活性化, ;;, Apr. 2016, 59, Suppl.1, S
• DGシグナリングと糖尿病関連疾患　膵β細胞のグルコース感知受容体　グルコースが産生する細胞内シグナルの再検討, ;;, Dec. 2015, 88回・38回, [2W20
• 肝の体性幹様細胞を機能肝細胞に効率よく分化誘導する補助肝臓の作成, ;;;;;;;;;;, Apr. 2017, 117回, PS
• グルコース感知受容体の分子実体の解明　CaSR/T1R3へテロダイマーの機能解析, ;;;, Apr. 2017, 60, Suppl.1, S
• PP特異的抗PPモノクローナル抗体の作製, ;;;;;;;, Apr. 2018, 61, Suppl.1, S
• Ppy-Creを介した発がん遺伝子活性化を用いた膵がんモデル(Pancreatic cancer model using Ppy-Cre mediated-oncogene activation), ;;;;;, Aug. 2021, 83, 3, 166
• マウス膵島が産生するGABAの主要合成酵素の解明, ;;;;;, Aug. 2021, 71, 3, 257
• Pancreatic polypeptide分泌メカニズムの解明, ;;;;;;, Apr. 2022, 98, 1, 362
• 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPP細胞の解析, ;;;;;;;;, Aug. 2019, 81, 3, 217
• 新規Ppyノックインレポーターマウスを用いた,内分泌前駆細胞としてのPpy発現細胞の解析, ;;;;;;;;, Apr. 2019, 62, Suppl.1, S
• プレプログルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, ;;;, Apr. 2019, 62, Suppl.1, S
• 新規Ppyノックインレポーターマウスを用いた、内分泌前駆細胞としてのPpy lineage cellの解析, ;;;;;;;;, Aug. 2020, 96, 1, 232
• グルカゴンシグナルによる膵PP細胞の過形成のメカニズムの解明, ;;;;;, Aug. 2020, 63, Suppl.1, S
• 肝臓特異的グルカゴン作用不全によるPP細胞量の制御メカニズムの解明, ;;;;;;;;;;, Apr. 2021, 97, 1, 321

MISC

• Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic beta-Cells, Yuko Nakagawa; Masahiro Nagasawa; Johan Medina; Itaru Kojima, Dec. 2015, PLOS ONE, 10, 12, e0144053

  DOI
• Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic beta-Cells, Yuko Nakagawa; Masahiro Nagasawa; Johan Medina; Itaru Kojima, Dec. 2015, PLOS ONE, 10, 12, e0144053

  DOI
• Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic beta-cells, Kunihisa Hamano; Yuko Nakagawa; Yoshiaki Ohtsu; Longfei Li; Johan Medina; Yuji Tanaka; Katsuyoshi Masuda; Mitsuhisa Komatsu; Itaru Kojima, Jul. 2015, JOURNAL OF ENDOCRINOLOGY, 226, 1, 57, 66

  DOI
• Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic beta-cells, Kunihisa Hamano; Yuko Nakagawa; Yoshiaki Ohtsu; Longfei Li; Johan Medina; Yuji Tanaka; Katsuyoshi Masuda; Mitsuhisa Komatsu; Itaru Kojima, Jul. 2015, JOURNAL OF ENDOCRINOLOGY, 226, 1, 57, 66

  DOI
• Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic beta-cells, Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Kunihisa Hamano; Johan Medina; Masahiro Nagasawa, May 2015, Journal of Diabetes Investigation, 6, 3, 256, 263, Book review

  DOI
• Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic beta-cells, Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Kunihisa Hamano; Johan Medina; Masahiro Nagasawa, May 2015, Journal of Diabetes Investigation, 6, 3, 256, 263, Book review

  DOI
• Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic beta-Cells, Itaru Kojima; Yuko Nakagawa; Kunihisa Hamano; Johan Medina; Longfei Li; Masahiro Nagasawa, May 2015, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38, 5, 674, 679

  DOI
• Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic beta-Cells, Itaru Kojima; Yuko Nakagawa; Kunihisa Hamano; Johan Medina; Longfei Li; Masahiro Nagasawa, May 2015, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38, 5, 674, 679

  DOI
• Sweet Taste Receptor Expressed in Pancreatic beta-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion, Yuko Nakagawa; Masahiro Nagasawa; Satoko Yamada; Akemi Hara; Hideo Mogami; Viacheslav O. Nikolaev; Martin J. Lohse; Noriatsu Shigemura; Yuzo Ninomiya; Itaru Kojima, Apr. 2009, PLOS ONE, 4, 4, e5106

  DOI
• Sweet Taste Receptor Expressed in Pancreatic beta-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion, Yuko Nakagawa; Masahiro Nagasawa; Satoko Yamada; Akemi Hara; Hideo Mogami; Viacheslav O. Nikolaev; Martin J. Lohse; Noriatsu Shigemura; Yuzo Ninomiya; Itaru Kojima, Apr. 2009, PLOS ONE, 4, 4, e5106

  DOI
• Multimodal function of the sweet taste receptor expressed in pancreatic beta-cells: generation of diverse patterns of intracellular signals by sweet agonists, Yuko Nakagawa; Masahiro Nagasawa; Hideo Mogami; Martin Lohse; Yuzo Ninomiya; Itaru Kojima, Oct. 2013, ENDOCRINE JOURNAL, 60, 10, 1191, 1206

  DOI
• Multimodal function of the sweet taste receptor expressed in pancreatic beta-cells: generation of diverse patterns of intracellular signals by sweet agonists, Yuko Nakagawa; Masahiro Nagasawa; Hideo Mogami; Martin Lohse; Yuzo Ninomiya; Itaru Kojima, Oct. 2013, ENDOCRINE JOURNAL, 60, 10, 1191, 1206

  DOI
• MCA1 and MCA2 That Mediate Ca2+ Uptake Have Distinct and Overlapping Roles in Arabidopsis, Takuya Yamanaka; Yuko Nakagawa; Kendo Mori; Masataka Nakano; Tomomi Imamura; Hajime Kataoka; Asuka Terashima; Kazuko Iida; Itaru Kojima; Takeshi Katagiri; Kazuo Shinozaki; Hidetoshi Iida, Mar. 2010, PLANT PHYSIOLOGY, 152, 3, 1284, 1296

  DOI
• MCA1 and MCA2 That Mediate Ca2+ Uptake Have Distinct and Overlapping Roles in Arabidopsis, Takuya Yamanaka; Yuko Nakagawa; Kendo Mori; Masataka Nakano; Tomomi Imamura; Hajime Kataoka; Asuka Terashima; Kazuko Iida; Itaru Kojima; Takeshi Katagiri; Kazuo Shinozaki; Hidetoshi Iida, Mar. 2010, PLANT PHYSIOLOGY, 152, 3, 1284, 1296

  DOI
• Arabidopsis plasma membrane protein crucial for Ca2+ influx and touch sensing in roots, Yuko Nakagawa; Takeshi Katagiri; Kazuo Shinozaki; Zhi Qi; Hitoshi Tatsumi; Takuya Furuichi; Akio Kishigami; Masahiro Sokabe; Itaru Kojima; Shusei Sato; Tomohiko Kato; Satoshi Tabata; Kazuko Iida; Asuka Terashima; Masataka Nakano; Mitsunobu Ikeda; Takuya Yamanaka; Hidetoshi Iida, Feb. 2007, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 9, 3639, 3644

  DOI
• Arabidopsis plasma membrane protein crucial for Ca2+ influx and touch sensing in roots, Yuko Nakagawa; Takeshi Katagiri; Kazuo Shinozaki; Zhi Qi; Hitoshi Tatsumi; Takuya Furuichi; Akio Kishigami; Masahiro Sokabe; Itaru Kojima; Shusei Sato; Tomohiko Kato; Satoshi Tabata; Kazuko Iida; Asuka Terashima; Masataka Nakano; Mitsunobu Ikeda; Takuya Yamanaka; Hidetoshi Iida, Feb. 2007, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104, 9, 3639, 3644

  DOI
• Plasma membrane protein OsMCA1 is involved in regulation of hypo-osmotic shock-induced Ca2+ influx and modulates generation of reactive oxygen species in cultured rice cells, Takamitsu Kurusu; Daisuke Nishikawa; Yukari Yamazaki; Mariko Gotoh; Masataka Nakano; Haruyasu Hamada; Takuya Yamanaka; Kazuko Iida; Yuko Nakagawa; Hikaru Saji; Kazuo Shinozaki; Hidetoshi Iida; Kazuyuki Kuchitsu, Jan. 2012, BMC PLANT BIOLOGY, 12, 11

  DOI
• Plasma membrane protein OsMCA1 is involved in regulation of hypo-osmotic shock-induced Ca2+ influx and modulates generation of reactive oxygen species in cultured rice cells, Takamitsu Kurusu; Daisuke Nishikawa; Yukari Yamazaki; Mariko Gotoh; Masataka Nakano; Haruyasu Hamada; Takuya Yamanaka; Kazuko Iida; Yuko Nakagawa; Hikaru Saji; Kazuo Shinozaki; Hidetoshi Iida; Kazuyuki Kuchitsu, Jan. 2012, BMC PLANT BIOLOGY, 12, 11

  DOI
• Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose, Johan Medina; Yuko Nakagawa; Masahiro Nagasawa; Anny Fernandez; Kazushige Sakaguchi; Tetsuya Kitaguchi; Itaru Kojima, Oct. 2016, JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 44, 23126, 23135

  DOI
• Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose, Johan Medina; Yuko Nakagawa; Masahiro Nagasawa; Anny Fernandez; Kazushige Sakaguchi; Tetsuya Kitaguchi; Itaru Kojima, Oct. 2016, JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 44, 23126, 23135

  DOI
• Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms, Longfei Li; Yoshiaki Ohtsu; Yuko Nakagawa; Katsuyoshi Masuda; Itaru Kojima, Aug. 2016, ENDOCRINE JOURNAL, 63, 8, 715, 725

  DOI
• Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms, Longfei Li; Yoshiaki Ohtsu; Yuko Nakagawa; Katsuyoshi Masuda; Itaru Kojima, Aug. 2016, ENDOCRINE JOURNAL, 63, 8, 715, 725

  DOI
• Interferon Regulatory Factor-2 Regulates Exocytosis Mechanisms Mediated by SNAREs in Pancreatic Acinar Cells, Hirosato Mashima; Taku Sato; Yasuo Horie; Yuko Nakagawa; Itaru Kojima; Toshiaki Ohteki; Hirohide Ohnishi, Sep. 2011, GASTROENTEROLOGY, 141, 3, 1102, U459

  DOI
• Prolonged Insulin Stimulation Down-regulates GLUT4 through Oxidative Stress-mediated Retromer Inhibition by a Protein Kinase CK2-dependent Mechanism in 3T3-L1 Adipocytes, Jinhui Ma; Yuko Nakagawa; Itaru Kojima; Hiroshi Shibata, Jan. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 1, 133, 142

  DOI
• Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states, Anya Medina; Yuko Nakagawa; Jinhui Ma; Longfei Li; Kunihisa Hamano; Toshio Akimoto; Yuzo Ninomiya; Itaru Kojima, Aug. 2014, ENDOCRINE JOURNAL, 61, 8, 797, 805

  DOI
• Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states, Anya Medina; Yuko Nakagawa; Jinhui Ma; Longfei Li; Kunihisa Hamano; Toshio Akimoto; Yuzo Ninomiya; Itaru Kojima, Aug. 2014, ENDOCRINE JOURNAL, 61, 8, 797, 805

  DOI
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells, Yoshiaki Ohtsu; Yuko Nakagawa; Masahiro Nagasawa; Shigeki Takeda; Hirokazu Arakawa; Itaru Kojima, Aug. 2014, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 394, 1-2, 70, 79

  DOI
• Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3, Yuko Nakagawa; Yoshiaki Ohtsu; Masahiro Nagasawa; Hiroshi Shibata; Itaru Kojima, Feb. 2014, ENDOCRINE JOURNAL, 61, 2, 119, 131

  DOI
• Role of the glucose-sensing receptor in insulin secretion, Itaru Kojima; Johan Medina; Yuko Nakagawa, Sep. 2017, DIABETES OBESITY & METABOLISM, 19, 1, 54, 62, Book review

  DOI
• Role of the glucose-sensing receptor in insulin secretion, Itaru Kojima; Johan Medina; Yuko Nakagawa, Sep. 2017, DIABETES OBESITY & METABOLISM, 19, 1, 54, 62, Book review

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells, Yosuke Masubuchi; Yuko Nakagawa; Johan Medina; Masahiro Nagasawa; Itaru Kojima; Mark M. Rasenick; Takeshi Inagaki; Hiroshi Shibata, May 2017, PLOS ONE, 12, 5, e0176841

  DOI
• T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells, Yosuke Masubuchi; Yuko Nakagawa; Johan Medina; Masahiro Nagasawa; Itaru Kojima; Mark M. Rasenick; Takeshi Inagaki; Hiroshi Shibata, May 2017, PLOS ONE, 12, 5, e0176841

  DOI
• The role of the sweet taste receptor in enteroendocrine cells and pancreatic β-cells, Itaru Kojima; Yuko Nakagawa, Oct. 2011, Diabetes and Metabolism Journal, 35, 5, 451, 457, Book review

  DOI
• Function of sweet taste receptor in pancreatic beta-cells, 2011
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Tsutomu Sasaki; Mayumi Shimpuku; Tomoya Kitazumi; Haruna Hiraga; Yuko Nakagawa; Hiroshi Shibata; Yuko Okamatsu-Ogura; Osamu Kikuchi; Hye-Jin Kim; Yuki Fujita; Jun Maruyama; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Masayuki Saito; Tadahiro Kitamura, 2013, Endocrine Journal, 60, 10, 1117, 1129

  DOI
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells, Yosuke Masubuchi; Yuko Nakagawa; Jinhui Ma; Tsutomu Sasaki; Tadahiro Kitamura; Yoritsuna Yamamoto; Hitoshi Kurose; Itaru Kojima; Hiroshi Shibata, 15 Jan. 2013, PLoS ONE, 8, 1, e54500

  DOI
• Diverse Signaling Systems Activated by the Sweet Taste-sensing Receptor in Human GLP-1-secreting Cells, Yoshiaki Ohtsu; Yuko Nakagawa; Masahiro Nagasawa; Hirokazu Arakawa; Itaru Kojima, Jun. 2014, DIABETES, 63, 1-2., A485, A486, Summary international conference

  DOI
• Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists., Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Anya Medina; Masahiro Nagasawa, Mar. 2014, Endocrinology and metabolism (Seoul, Korea), 29, 1, 12, 9

  DOI
• The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic β-Cells., 2011, Diabetes Metab J., 35, 451, 457

  DOI
• Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells., 2011, Gastroenterology., 141, 1102, 1113

  DOI
• Function of sweet taste receptor in pancreatic beta-cells, 2011, seikagaku
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Tsutomu Sasaki; Mayumi Shimpuku; Tomoya Kitazumi; Haruna Hiraga; Yuko Nakagawa; Hiroshi Shibata; Yuko Okamatsu-Ogura; Osamu Kikuchi; Hye-Jin Kim; Yuki Fujita; Jun Maruyama; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Masayuki Saito; Tadahiro Kitamura, 2013, Endocrine Journal, 60, 10, 1117, 1129

  DOI
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells, Yosuke Masubuchi; Yuko Nakagawa; Jinhui Ma; Tsutomu Sasaki; Tadahiro Kitamura; Yoritsuna Yamamoto; Hitoshi Kurose; Itaru Kojima; Hiroshi Shibata, 15 Jan. 2013, PLoS ONE, 8, 1, e54500

  DOI
• Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists., Itaru Kojima; Yuko Nakagawa; Yoshiaki Ohtsu; Anya Medina; Masahiro Nagasawa, Mar. 2014, Endocrinology and metabolism (Seoul, Korea), 29, 1, 12, 9

  DOI
• Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3., Yuko Nakagawa; Yoshiaki Ohtsu; Masahiro Nagasawa; Hiroshi Shibata; Itaru Kojima, 2014, Endocrine journal, 61, 2, 119, 31

  DOI
• Prolonged insulin stimulation down-regulates GLUT4 through oxidative stress-mediated retromer inhibition by a protein kinase CK2-dependent mechanism in 3T3-L1 adipocytes, Jinhui Ma; Yuko Nakagawa; Itaru Kojima; Hiroshi Shibata, 03 Jan. 2014, Journal of Biological Chemistry, 289, 1, 133, 142

  DOI
• 肝の体性幹様細胞を機能肝細胞に効率よく分化誘導する補助肝臓の作成, 小暮 公孝; 柴田 宏; 長澤 雅裕; 中川 祐子; 李 龍飛; 小島 至; 稲垣 毅; 根本 雅明; 石崎 政利; 桑野 博行; 幕内 雅敏, Apr. 2017, 日本外科学会定期学術集会抄録集, 117回, PS, 129
• Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages., NAGASAWA Masahiro; NAKAGAWA Yuko; TANAKA Shigeyasu; KOJIMA Itaru, 2006, 210, 3, 692, 702

  DOI

Presentations

• Genetically induced immortalization of Ppy-expressing cells result in Pancreatic Ductal Adenocarcinoma, Ofejiro B. Pereye, Takashi Sato, Yuko Nakagawa, Ayako Fukunaka, Akihisa Fukuda, Hiroki Mizukami and Yoshio Fujitani, 18 Feb. 2023
• ‘Genetically induced immortalization of Ppy-expressing cells result in Pancreatic Ductal Adenocarcinoma’, Ofejiro B. Pereye, Takashi Sato, Yuko Nakagawa, Ayako Fukunaka, Shuhei Aoyama,Yuya Nishida, Hirotaka Watada, Akihisa Fukuda, Hiroki Mizukami and Yoshio Fujitani, 10 Nov. 2022
• 特定時期における膵内分泌細胞の運命変換機序の解明, 佐藤 隆史 ,　中川 祐子 , 深石 貴大 ,　福中 彩子 , 藤谷 与士夫, 北関東医学会, 29 Sep. 2022
• Pancreatic polypeptide分泌メカニズムの解明, 中川 祐子, 齊藤 大祐, Ofejiro B. Pereye, 福中 彩子, 佐藤 隆史, 丸山　順裕, 藤谷 与士夫, 第95回日本内分泌学会学術総会, 02 Jun. 2022
• ‘A novel Islet-derived mouse pancreatic ductal adenocarcinoma model’, Ofejiro B. Pereye, Takashi Sato, Yuko Nakagawa, Ayako Fukunaka and Yoshio Fujitani, 第35日本糖尿病・肥満動物学会年次学術集会, 22 May 2022
• A trial for the establishment of pancreatic endocrine cell lines using a new mouse model, Ofejiro B. Pereye, Takashi Sato, Yuko Nakagawa, Ayako Fukunaka, and Yoshio Fujitani, 第67回北関東医学会総会, 24 Sep. 2020, 24 Sep. 2020, 25 Sep. 2020
• GIPはPP分泌を促進する　ー新規PP ELISA系を用いた解析ー, 齊藤 大祐, 中川祐子, Ofejiro B. Pereye, 福中彩子,　深石貴大,　佐藤隆史, 丸山順裕, 綿田裕孝, 藤谷与士夫, 第94回 日本内分泌学会学術総会, 24 Apr. 2021, 22 Apr. 2021, 24 Apr. 2021, Japanese
• プログルカゴン遺伝子産物による膵PP細胞の増殖制御機構の解明, 中川 祐子, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫, 第17回 生体機能研究会, 27 Jul. 2018, 27 Jul. 2018, 28 Jul. 2018, Japanese, Domestic conference
• Proliferative regulation of pancreatic polypeptide producing cells by the proglucagon, Yuko Nakagawa, Yoshitaka Hayashi, Tadahiro Kitamura, Takuro Horii, Izuho Hatada, and Yoshio Fujitani., The 4th IMCR Symposium on Endocrine and Metabolism, 19 Nov. 2018, 19 Nov. 2018, 2018, English, International conference
• PP特異的抗PPモノクローナル抗体の作製, 中川 祐子, 原　朱美, 中尾 啓子, 田蒔 基行, 松久 宗英, 水上 浩哉, 綿田 裕孝, 藤谷 与士夫., 第61回 日本糖尿病学会年次学術集会, 26 May 2018, 24 May 2018, 26 May 2018, Japanese
• グルカゴンシグナルによる膵PP細胞の増殖制御メカニズムの解明, 中川 祐子, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫, 20200201, 01 Feb. 2020, 31 Jan. 2020, 01 Feb. 2020, Domestic conference
• グルカゴンシグナルによる膵PP細胞の増殖制御メカニズムの解明, 中川 祐子, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫., 第5回 群馬大学生体調節研究所 内分泌代謝シンポジウム, 14 Nov. 2019, 14 Nov. 2019, 15 Nov. 2019, Japanese, Domestic conference
• グルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, 中川 祐子, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫, 第18回 生体機能研究会, 26 Jul. 2019, 26 Jul. 2019, 27 Jul. 2019, Domestic conference
• グルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, 中川 祐子, 林 良敬, 北村 忠弘, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫, 第62回 日本糖尿病学会年次学術集会, 25 May 2019, 23 May 2019, 25 May 2019, Japanese, Domestic conference
• グルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, 2. ポスター, 中川 祐子, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫., 第63回 日本糖尿病学会年次学術集会, 13 Oct. 2020, 05 Oct. 2020, 16 Oct. 2020, Japanese
• 肝臓特異的グルカゴン作用不全によるPP細胞量の制御メカニズムの解明, 中川 祐子, Ofejiro B. Pereye, 齊藤 大祐, 深石 貴大, 福中 彩子, 佐藤 隆史, 林 良敬, 北村 忠弘, 堀居 拓郎, 畑田 出穂, 藤谷 与士夫., 第94回 日本内分泌学会学術総会, 24 Apr. 2021, 22 Apr. 2021, 24 Apr. 2021, Japanese
• グルコース作用における甘味受容体の関与：代謝経路との連関, 2013
• 膵β細胞におけるグルコース作用：代謝に依存しないcAMPシグナル伝達経路の解明, 2012
• 膵β細胞におけるグルコース作用：代謝に依存しないDAGシグナル伝達経路の解明, 2011
• Gs共役型T1R3ホモマー甘味受容体による微小管脱重合とRho活性化を介したインスリン依存性グルコース輸送の抑制, 2014
• 膵β細胞におけるグルコース感知受容体T1R3の発現変化, 2014
• ラクチゾールは膵β細胞のグルコース感知受容体T1R3を抑制する, 2014
• Expression of the Glucose-sensing Receptor T1R3 in Pancreatic Islets, 2014
• Activators of the Sweet Taste Receptor Energize Mitochondria and Augment ATP Production in Glucose-responsive MIN6, 2014
• A Heterodimer of the Calcium-sensing Receptor and T1R3 Functions As Glucose-sensing Receptor, 2016
• T1R3/CaSR へテロダイマーはグルコース感知受容体として機能する, 2016
• グルコース感知受容体を介する代謝促進機構, 2016
• グルコース感知受容体 T1R3による糖代謝の促進機構, 2014
• GLP1分泌細胞HuTu-80における甘味受容体の機能解析, 2013
• Expression of the Glucose-sensing Receptor T1R3 in Pancreatic Islets, 2014
• Activators of the Sweet Taste Receptor Energize Mitochondria and Augment ATP Production in Glucose-responsive MIN6, 2014
• A Heterodimer of the Calcium-sensing Receptor and T1R3 Functions As Glucose-sensing Receptor, 2016
• シロイヌナズナのCa2+透過性伸展活性化陽イオンチャネル候補AtMID1Aの接触刺激応答における機能解析, 中川 祐子, Dec. 2004
• シロイヌナズナの伸展活性化Ca2+透過チャネル候補の分子遺伝学的研究, 中川 祐子, Oct. 2001
• シロイヌナズナの伸展活性化Ca2+透過チャネル候補の分子遺伝学的研究, 中川 祐子, Mar. 2006
• シロイヌナズナのCa2+透過性伸展活性化陽イオンチャネル候補AtMID1Aの接触刺激応答における機能解析, 中川 祐子, Dec. 2004
• シロイヌナズナの伸展活性化Ca2+透過チャネル候補の分子遺伝学的研究, 中川 祐子, Oct. 2001

Industrial Property Rights

• Patent right, -

Research Projects

• 01 Apr. 2022, 31 Mar. 2023

Research Grants & Projects

• 20220401, 20230331