Researcher Profile and Settings

Researcher

• Name

  Sato Hiroo

Affiliation

• Heavy Ion Medical Center(Research Institute), Assistant Professor

Profile and Settings

• Name

  Sato, Hiro

Alternate Names

• Hiro Sato

Affiliation

• Gunma University, Research Center for Heavy Particle Beam Medicine, Assistant Professor

Affiliation

• Affiliation

  Research Center fo Heavy Particle Beam Medicine

Education

• Apr. 2010, Nov. 2014, Gunma University, Graduate School of Medicine
• Apr. 2002, Mar. 2008, Gunma University, Faculty of Medicine, School of Medicine

Association Memberships

• JAPAN RADIOLOGICAL SOCIETY
• The American Society for Radiation Oncology
• THE JAPANESE CANCER ASSOCIATION
• JAPAN SOCIETY OF CLINICAL ONCOLOGY
• JAPANESE SOCIETY FOR RADIATION ONCOLOGY

Research Experience

• Aug. 2017, 9999, Gunma University, Research Center for Heavy Particle Beam Medicine, Assistant prof lv
• Apr. 2014, Jul. 2017, Gunma University, University Hospital, Radiology, Expert etc
• Oct. 2012, Mar. 2014
• Apr. 2012, Sep. 2012, Gunma University, University Hospital, Radiology, Expert etc
• Apr. 2010, Mar. 2012
• Apr. 2008, Mar. 2010

Research Activities

Research Areas

• Life sciences, Radiology

Published Papers

• Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy., Endang Nuryadi; Yasushi Sasaki; Yoshihiko Hagiwara; Tiara Bunga Mayang Permata; Hiro Sato; Shuichiro Komatsu; Yuya Yoshimoto; Kazutoshi Murata; Ken Ando; Nobuteru Kubo; Noriyuki Okonogi; Yosuke Takakusagi; Akiko Adachi; Mototaro Iwanaga; Keisuke Tsuchida; Tomoaki Tamaki; Shin-Ei Noda; Yuka Hirota; Atsushi Shibata; Tatsuya Ohno; Takashi Tokino; Takahiro Oike; Takashi Nakano, 24 Aug. 2018, Oncotarget, 9, 66, 32642, 32652, Scientific journal

  DOI
• Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions., Hiroki Ushijima; Yoshiyuki Suzuki; Takahiro Oike; Mayumi Komachi; Yuya Yoshimoto; Ken Ando; Noriyuki Okonogi; Hiro Sato; Shin-Ei Noda; Jun-Ichi Saito; Takashi Nakano, Jul. 2015, Journal of radiation research, 56, 4, 663, 8, Scientific journal

  DOI
• Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation., Yuya Yoshimoto; Takahiro Oike; Noriyuki Okonogi; Yoshiyuki Suzuki; Ken Ando; Hiro Sato; Shin-ei Noda; Mayu Isono; Kousaku Mimura; Koji Kono; Takashi Nakano, May 2015, Journal of radiation research, 56, 3, 509, 14, Scientific journal

  DOI
• Changes in bone mineral density in uterine cervical cancer patients after radiation therapy., Noriyuki Okonogi; Jun-ichi Saitoh; Yoshiyuki Suzuki; Shin-ei Noda; Tatsuya Ohno; Takahiro Oike; Yu Ohkubo; Ken Ando; Hiro Sato; Takashi Nakano, 01 Dec. 2013, International journal of radiation oncology, biology, physics, 87, 5, 968, 74, Scientific journal

  DOI
• Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy., Takahiro Oike; Tatsuya Ohno; Shin-ei Noda; Hiro Sato; Tomoaki Tamaki; Hiroki Kiyohara; Ken Ando; Takashi Nakano, May 2013, Journal of radiation research, 54, 3, 474, 8, Scientific journal

  DOI
• Changes in Rectal Dose Due to Alterations in Beam Angles for Setup Uncertainty and Range Uncertainty in Carbon-Ion Radiotherapy for Prostate Cancer., Yoshiki Kubota; Hidemasa Kawamura; Makoto Sakai; Ryou Tsumuraya; Mutsumi Tashiro; Ken Yusa; Nobuteru Kubo; Hiro Sato; Masahiro Kawahara; Hiroyuki Katoh; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, 2016, PloS one, 11, 4, e0153894, Scientific journal

  DOI
• Identification of DNA double strand breaks at chromosome boundaries along the track of particle irradiation., Atsuko Niimi; Motohiro Yamauchi; Siripan Limsirichaikul; Ryota Sekine; Takahiro Oike; Hiro Sato; Keiji Suzuki; Kathryn D Held; Takashi Nakano; Atsushi Shibata, Aug. 2016, Genes, chromosomes & cancer, 55, 8, 650, 60, Scientific journal

  DOI
• Anti-tumor immunity is fundamental to the therapeutic efficacy of irradiation., YOSHIMOTO,Yuya; SUZUKI,Yoshiyuki; MIURA,Kousaku; ANDO,Ken; OIKE,Takahiro; SATO,Hiro; OKONOGI,NOriyuki; MARUYAMA,Takanori; IZAWA,Shinitirou; NODA,Shin-ei; FUJII,Hideki; KONO,KOji; NAKANO,Takashi, Mar. 2014, PLoS one, 9, e92572, Research society
• Dose-volume prediction of radiationrelated complications after hypofractionated conformal radiotherapy for brain metastases in critical areas, Inoue HK; Sato H; Suzuki Y; Saitou JI; Noda SE; Seto KI; Torikai K; Nakano T, 2014, Cureus, 6, e189, Research society
• Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model., Yuya Yoshimoto; Yoshiyuki Suzuki; Kousaku Mimura; Ken Ando; Takahiro Oike; Hiro Sato; Noriyuki Okonogi; Takanori Maruyama; Shinichiro Izawa; Shin-ei Noda; Hideki Fujii; Koji Kono; Takashi Nakano, 2014, PloS one, 9, 3, e92572, Scientific journal

  DOI
• Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the Martinez Universal Perineal Interstitial Template (MUPIT) in computed tomography-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors?, Takahiro Oike; Tatsuya Ohno; Shin-Ei Noda; Hiroki Kiyohara; Ken Ando; Kei Shibuya; Tomoaki Tamaki; Yosuke Takakusagi; Hiro Sato; Takashi Nakano, 16 Oct. 2014, Radiation oncology (London, England), 9, 222, 222, Scientific journal

  DOI
• In Reply to Minhas and Tran., Noriyuki Okonogi; Yoshiyuki Suzuki; Hiro Sato; Takahiro Oike; Yuya Yoshimoto; Kosaku Mimura; Shin-Ei Noda; Masahiko Okamoto; Tomoaki Tamaki; Yukie Morokoshi; Sumitaka Hasegawa; Hiroko Ohgaki; Hideaki Yokoo; Takashi Nakano, 01 May 2019, International journal of radiation oncology, biology, physics, 104, 1, 223, 224

  DOI
• Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study., Hiroshi K Inoue; Hiro Sato; Yoshiyuki Suzuki; Jun-ichi Saitoh; Shin-ei Noda; Ken-ichi Seto; Kota Torikai; Hideyuki Sakurai; Takashi Nakano, 17 Oct. 2014, Radiation oncology (London, England), 9, 231, 231, Scientific journal

  DOI
• Five-fraction CyberKnife radiotherapy for large brain metastases in critical areas: impact on the surrounding brain volumes circumscribed with a single dose equivalent of 14 Gy (V14) to avoid radiation necrosis., Hiroshi K Inoue; Hiro Sato; Ken-ichi Seto; Kota Torikai; Yoshiyuki Suzuki; Jun-ichi Saitoh; Shin-ei Noda; Takashi Nakano, 01 Mar. 2014, Journal of radiation research, 55, 2, 334, 42, Scientific journal

  DOI
• HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer., Hiro Sato; Yoshiyuki Suzuki; Munenori Ide; Toshihide Katoh; Shin-Ei Noda; Ken Ando; Takahiro Oike; Yuya Yoshimoto; Noriyuki Okonogi; Kousaku Mimura; Takayuki Asao; Hiroyuki Kuwano; Takashi Nakano, 2014, PloS one, 9, 9, e108122, Scientific journal

  DOI
• Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells., Nakako Izumi Nakajima; Atsuko Niimi; Mayu Isono; Takahiro Oike; Hiro Sato; Takashi Nakano; Atsushi Shibata, Aug. 2017, Oncology reports, 38, 2, 693, 702, Scientific journal

  DOI
• p53 deficiency augments nucleolar instability after ionizing irradiation., Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi Shibata, Dec. 2019, Oncology reports, 42, 6, 2293, 2302, Scientific journal

  DOI
• Regulation of programmed death-ligand 1 expression in response to DNA damage in cancer cells: Implications for precision medicine., Hiro Sato; Penny A Jeggo; Atsushi Shibata, Nov. 2019, Cancer science, 110, 11, 3415, 3423, Scientific journal

  DOI
• Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy., Maxim Shevtsov; Hiro Sato; Gabriele Multhoff; Atsushi Shibata, 2019, Frontiers in oncology, 9, 156, 156, Scientific journal

  DOI
• Base excision repair regulates PD-L1 expression in cancer cells., Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Hiro Sato; Takaaki Yasuhara; Takahiro Oike; Soehartati Gondhowiardjo; Kathryn D Held; Takashi Nakano; Atsushi Shibata, Jun. 2019, Oncogene, 38, 23, 4452, 4466, Scientific journal

  DOI
• DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells., Hiro Sato; Atsuko Niimi; Takaaki Yasuhara; Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Mayu Isono; Endang Nuryadi; Ryota Sekine; Takahiro Oike; Sangeeta Kakoti; Yuya Yoshimoto; Kathryn D Held; Yoshiyuki Suzuki; Koji Kono; Kiyoshi Miyagawa; Takashi Nakano; Atsushi Shibata, 24 Nov. 2017, Nature communications, 8, 1, 1751, 1751, Scientific journal

  DOI
• BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation., Mayu Isono; Atsuko Niimi; Takahiro Oike; Yoshihiko Hagiwara; Hiro Sato; Ryota Sekine; Yukari Yoshida; Shin-Ya Isobe; Chikashi Obuse; Ryotaro Nishi; Elena Petricci; Shinichiro Nakada; Takashi Nakano; Atsushi Shibata, 10 Jan. 2017, Cell reports, 18, 2, 520, 532, Scientific journal

  DOI
• Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin., Daijiro Kobayashi; Takahiro Oike; Atsushi Shibata; Atsuko Niimi; Yoshiki Kubota; Makoto Sakai; Napapat Amornwhichet; Yuya Yoshimoto; Yoshihiko Hagiwara; Yuka Kimura; Yuka Hirota; Hiro Sato; Mayu Isono; Yukari Yoshida; Takashi Kohno; Tatsuya Ohno; Takashi Nakano, 16 Jan. 2017, Scientific reports, 7, 40588, 40588, Scientific journal

  DOI
• Moderately hypofractionated carbon ion radiotherapy for prostate cancer; a prospective observational study "GUNMA0702"., Hidemasa Kawamura; Nobuteru Kubo; Hiro Sato; Tatsuji Mizukami; Hiroyuki Katoh; Hitoshi Ishikawa; Tatsuya Ohno; Hiroshi Matsui; Kazuto Ito; Kazuhiro Suzuki; Takashi Nakano, 30 Jan. 2020, BMC cancer, 20, 1, 75, 75, Scientific journal

  DOI
• Long-term outcome of hypofractionated intensity-modulated radiotherapy using TomoTherapy for localized prostate cancer: A retrospective study., Yosuke Takakusagi; Hidemasa Kawamura; Masahiko Okamoto; Takuya Kaminuma; Nobuteru Kubo; Tatsuji Mizukami; Hiro Sato; Masahiro Onishi; Nobuaki Ohtake; Tetsuo Sekihara; Takashi Nakano, 2019, PloS one, 14, 2, e0211370, Scientific journal

  DOI
• Hypofractionated Intensity-modulated Radiotherapy for Intermediate- and High-risk Prostate Cancer: A Retrospective Study., Kubo N; Kawamura H; Oike T; Sato H; Iwanaga M; Mizukami T; Adachi A; Matsui H; Ito K; Suzuki K; Nakano T, Jul. 2019, In vivo (Athens, Greece), 33, 4, 1235, 1241

  DOI
• Deep learning-assisted literature mining for in vitro radiosensitivity data., Shuichiro Komatsu; Takahiro Oike; Yuka Komatsu; Yoshiki Kubota; Makoto Sakai; Toshiaki Matsui; Endang Nuryadi; Tiara Bunga Mayang Permata; Hiro Sato; Hidemasa Kawamura; Masahiko Okamoto; Takuya Kaminuma; Kazutoshi Murata; Naoko Okano; Yuka Hirota; Tatsuya Ohno; Jun-Ichi Saitoh; Atsushi Shibata; Takashi Nakano, Oct. 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 139, 87, 93, Scientific journal

  DOI
• Dosimetric parameters predictive of nasolacrimal duct obstruction after carbon-ion radiotherapy for head and neck carcinoma., Nobuteru Kubo; Yoshiki Kubota; Hidemasa Kawamura; Takahiro Oike; Makoto Sakai; Takuya Kumazawa; Yuhei Miyasaka; Shohei Okazaki; Daijiro Kobayashi; Hiro Sato; Tatsuji Mizukami; Atsushi Musha; Katsuyuki Shirai; Jun-Ichi Saitoh; Satoshi Yokoo; Kazuaki Chikamatsu; Tatsuya Ohno; Takashi Nakano, Dec. 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 141, 72, 77, Scientific journal

  DOI
• Quality of life in prostate cancer patients receiving particle radiotherapy: A review of the literature., Hidemasa Kawamura; Nobuteru Kubo; Hiro Sato; Yuhei Miyasaka; Hiroshi Matsui; Kazuto Ito; Kazuhiro Suzuki; Tatsuya Ohno, Jan. 2020, International journal of urology : official journal of the Japanese Urological Association, 27, 1, 24, 29, Scientific journal

  DOI
• Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia., Ken Ando; Yoshiyuki Suzuki; Takuya Kaminuma; Yuya Yoshimoto; Takahiro Oike; Noriyuki Okonogi; Hiro Sato; Tomoaki Tamaki; Shin-Ei Noda; Kosaku Mimura; Takashi Nakano, 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 35, 1, 226, 231, Scientific journal

  DOI
• Analysis of programmed death-ligand 1 expression in primary normal human dermal fibroblasts after DNA damage., Yoshihiko Hagiwara; Hiro Sato; Tiara Bunga Mayang Permata; Atsuko Niimi; Motohiro Yamauchi; Takahiro Oike; Takashi Nakano; Atsushi Shibata, Aug. 2018, Human immunology, 79, 8, 627, 631, Scientific journal

  DOI
• High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells., Masahiro Onishi; Noriyuki Okonogi; Takahiro Oike; Yuya Yoshimoto; Hiro Sato; Yoshiyuki Suzuki; Tadashi Kamada; Takashi Nakano, 01 Sep. 2018, Journal of radiation research, 59, 5, 541, 546, Scientific journal

  DOI
• Combination Therapy of Intravenously Injected Microglia and Radiation Therapy Prolongs Survival in a Rat Model of Spontaneous Malignant Glioma., Noriyuki Okonogi; Yoshiyuki Suzuki; Hiro Sato; Takahiro Oike; Yuya Yoshimoto; Kosaku Mimura; Shin-Ei Noda; Masahiko Okamoto; Tomoaki Tamaki; Yukie Morokoshi; Sumitaka Hasegawa; Hiroko Ohgaki; Hideaki Yokoo; Takashi Nakano, 01 Nov. 2018, International journal of radiation oncology, biology, physics, 102, 3, 601, 608, Scientific journal

  DOI
• Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation., Yoshihiko Hagiwara; Takahiro Oike; Atsuko Niimi; Motohiro Yamauchi; Hiro Sato; Siripan Limsirichaikul; Kathryn D Held; Takashi Nakano; Atsushi Shibata, 01 Jan. 2019, Journal of radiation research, 60, 1, 69, 79, Scientific journal

  DOI
• 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation., Yoshihiko Hagiwara; Atsuko Niimi; Mayu Isono; Motohiro Yamauchi; Takaaki Yasuhara; Siripan Limsirichaikul; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi Shibata, 12 Dec. 2017, Oncotarget, 8, 65, 109370, 109381, Scientific journal

  DOI
• An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T-cell immunotherapy and radiotherapy., Hiro Sato; Yoshiyuki Suzuki; Yuya Yoshimoto; Shin-Ei Noda; Kazutoshi Murata; Yosuke Takakusagi; Atsushi Okazaki; Tetsuo Sekihara; Takashi Nakano, Apr. 2017, Clinical case reports, 5, 4, 380, 384

  DOI
• Translational Research to Improve the Efficacy of Carbon Ion Radiotherapy: Experience of Gunma University., Takahiro Oike; Hiro Sato; Shin-Ei Noda; Takashi Nakano, 2016, Frontiers in oncology, 6, 139, 139, Scientific journal

  DOI
• Translational Research to Improve the Efficacy of Carbon Ion Radiotherapy: Experience of Gunma University, Oike Takahiro; Sato Hiro; Noda Shin-ei; Nakano Takashi, 2016, FRONTIERS IN ONCOLOGY, 6, 139

  DOI
• Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment., Takahiro Oike; Tatsuya Ohno; Shin-Ei Noda; Tomomi Murata; Takashi Hirakawa; Junko Hirato; Mio Furuya; Hiro Sato; Yuka Hirota; Takashi Minegishi; Takashi Nakano, Jan. 2016, Clinical case reports, 4, 1, 54, 61

  DOI
• Image Fusion for Radiosurgery, Neurosurgery and Hypofractionated Radiotherapy., Hiroshi K Inoue; Atsushi Nakajima; Hiro Sato; Shin-Ei Noda; Jun-Ichi Saitoh; Yoshiyuki Suzuki, Mar. 2015, Cureus, 7, 3, e252, Scientific journal

  DOI
• Evaluation of Carbon Ion Radiation-Induced Trismus in Head and Neck Tumors Using Dose-Volume Histograms., Atsushi Musha; Hirofumi Shimada; Nobuteru Kubo; Hidemasa Kawamura; Naoko Okano; Yuhei Miyasaka; Hiro Sato; Katsuyuki Shirai; Jun-Ichi Saitoh; Satoshi Yokoo; Kazuaki Chikamatsu; Tatsuya Ohno, 25 Oct. 2020, Cancers, 12, 11, Scientific journal

  DOI
• Induction of Micronuclei in Cervical Cancer Treated with Radiotherapy., Daijiro Kobayashi; Takahiro Oike; Kazutoshi Murata; Daisuke Irie; Yuka Hirota; Hiro Sato; Atsushi Shibata; Tatsuya Ohno, 03 Sep. 2020, Journal of personalized medicine, 10, 3, Scientific journal

  DOI
• Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status, Naoto Osu; Daijiro Kobayashi; Katsuyuki Shirai; Atsushi Musha; Hiro Sato; Yuka Hirota; Atsushi Shibata; Takahiro Oike; Tatsuya Ohno, 25 Jul. 2020, Journal of Personalized Medicine, 10, 3, 71, 71, Scientific journal

  DOI
• Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment., Hiro Sato; Noriyuki Okonogi; Takashi Nakano, May 2020, International journal of clinical oncology, 25, 5, 801, 809, Scientific journal

  DOI
• Kinetics of Prostate-Specific Antigen after Carbon Ion Radiotherapy for Prostate Cancer., Narisa Dewi Maulany Darwis; Takahiro Oike; Hidemasa Kawamura; Masahiro Kawahara; Nobuteru Kubo; Hiro Sato; Yuhei Miyasaka; Hiroyuki Katoh; Hitoshi Ishikawa; Hiroshi Matsui; Yoshiyuki Miyazawa; Kazuto Ito; Kazuhiro Suzuki; Soehartati Gondhowiardjo; Takashi Nakano; Tatsuya Ohno, 04 Mar. 2020, Cancers, 12, 3, Scientific journal

  DOI
• Impact of Inter-fractional Anatomical Changes on Dose Distributions in Passive Carbon-Ion Radiotherapy for Prostate Cancer: Comparison of Vertical and Horizontal Fields., Ayaka Yokoyama; Yoshiki Kubota; Hidemasa Kawamura; Yuhei Miyasaka; Nobuteru Kubo; Hiro Sato; Satoshi Abe; Kazuhisa Tsuda; Takayuki Sutou; Tatsuya Ohno; Takashi Nakano, 2020, Frontiers in oncology, 10, 1264, 1264, Scientific journal

  DOI
• Skin Dose Reduction by Layer-Stacking Irradiation in Carbon Ion Radiotherapy for Parotid Tumors., Nobuteru Kubo; Yoshiki Kubota; Takahiro Oike; Hidemasa Kawamura; Makoto Sakai; Ayaka Imamura; Shuichiro Komatsu; Yuhei Miyasaka; Hiro Sato; Atsushi Musha; Naoko Okano; Katsuyuki Shirai; Jun-Ichi Saitoh; Kazuaki Chikamatsu; Tatsuya Ohno, 2020, Frontiers in oncology, 10, 1396, 1396, Scientific journal

  DOI
• DNA Repair and Signaling in Immune-Related Cancer Therapy., Sangeeta Kakoti; Hiro Sato; Siddhartha Laskar; Takaaki Yasuhara; Atsushi Shibata, 2020, Frontiers in molecular biosciences, 7, 205, 205, Scientific journal

  DOI
• Efficacy and Feasibility of Salvage Re-Irradiation with CyberKnife for In-Field Neck Lymph Node Recurrence: A Retrospective Study., Daijiro Kobayashi; Hiro Sato; Jun-Ichi Saitoh; Takahiro Oike; Atsushi Nakajima; Shin-Ei Noda; Shingo Kato; Mototaro Iwanaga; Tsuneo Shimizu; Takashi Nakano, 07 Nov. 2019, Journal of clinical medicine, 8, 11, Scientific journal

  DOI
• [Radiotherapy and PD-L1 Expression]., Hiro Sato; Noriyuki Okonogi; Yuya Yoshimoto; Tomoaki Tamaki; Yoshiyuki Suzuki, May 2019, Gan to kagaku ryoho. Cancer & chemotherapy, 46, 5, 845, 849, Scientific journal
• How do we approach to the difficult－to－treat Japanese case. Combination therapy of Immunotherapy and Radiotherapy（Immuno－radiotherapy）, ;;;, 2020, Skin Cancer, 35, 3, 98, 104

  DOI
• 炭素イオン線特異的なDNA二本鎖切断修復開始機構の解析, ;;;;;;;, Oct. 2015, 1回, 6
• 高LET重粒子線照射により誘発される2つの異なる染色体間にまたがるクラスターDNA損傷の同定, ;;;;;;;;;, Dec. 2015, 88回・38回, [1P0630]
• 炭素線特異的なDNA end resection機序の解析, ;;;;;;;, Dec. 2015, 88回・38回, [1P0651]
• 多様なDNA損傷応答の統合制御機構2015　ゲノム不安定性の病態解明研究　BRCA1によるDSB end resectionの時空間的制御, ;;;;;;;;;;, Dec. 2015, 88回・38回, [3W2
• 放射線治療と免疫細胞療法の同時併用療法が施行された、全身状態不良の腎癌術後再発の1例, ;;;;;;;, Apr. 2016, 104回, PP2
• 手術不能原発性尿管癌に対する重粒子線治療の初期経験, ;;;;;;;;;;;;, Apr. 2016, 104回, PP3
• 総合　基礎研究が導くがん治療の新戦略　放射線治療時に免疫チェックポイント阻害剤の抗腫瘍効果増強を導くDNA修復機構の解明, ;;;;, Oct. 2016, 54回, MS23
• 前立腺　放射線治療　前立腺癌に対する重粒子線治療の初期経験(前向き観察研究GUNMA0702), ;;;;;;;;;;;;;;, Oct. 2016, 54回, WS23
• 【腫瘍に対する放射線治療-高度化・個別化治療へ-】放射線治療による抗腫瘍免疫誘導機序, ;;, Aug. 2017, 75, 8, 1289
• 前立腺癌術後PSA再発に対するTomoTherapyを用いた救済放射線療法の検討, ;;;;;;;;;;;;, Apr. 2017, 105回, OP82
• DNA二本鎖切断修復経路選択制に対する線エネルギー付与依存性の解析, ;;;;;;, Oct. 2016, 59回, 3
• 限局性前立腺癌で放射線治療を受けた患者における意思決定と健康関連QOLの検討, ;;;;;;;;;;;;, Apr. 2018, 106回, OP
• 前立腺癌に対する短期ホルモン療法併用重粒子線治療後のPSA値変化, ;;;;;;;;;;;;, Apr. 2018, 106回, PP1
• 特集 放射線治療-最近の話題- 放射線治療により誘導される抗腫瘍免疫と"免疫放射線療法", ;;, Nov. 2017, 62, 12, 1663, 1671

  DOI
• 特集 放射線療法と免疫療法との併用療法を考える 免疫放射線療法-放射線療法と免疫療法との併用療法, ;;;;, Oct. 2019, 64, 11, 1325, 1329

  DOI
• 群馬大学における頭頸部非扁平上皮癌に対する重粒子線治療の長期成績, ;;;;;;;;;;;;;;, Jul. 2020, 46, 2, 161
• Basic study of immunoradiation therapy using anti-PD-L1 antibody, Hara, Takamitsu;Sato, Hiroo;Suzuki, Yoshiyuki;Ohno, Tatsuya;Okazaki, Atsushi, 2022, CANCER SCIENCE, 113, 613, 613
• 前立腺　生検と初期診断　前立腺癌に対する放射線治療前の便潜血検査の有用性の検討, ;;;;;;;;;;;;;;, Oct. 2016, 54回, WS25
• 泌尿器　泌尿器がん治療の進歩　手術不能原発性尿管癌に対する重粒子線治療の初期経験, ;;;;;;;;;;;;;, Oct. 2016, 54回, WS63
• 総合　診断・予測　重粒子線治療における生体内での深部線量分布の精度測定法の確立, ;;;;;;;;;, Oct. 2016, 54回, WS85
• 非小細胞肺癌細胞においてEGFR変異状況は炭素イオン線照射療法の相対的生物学的有効性に影響を及ぼす(EGFR mutation status affects the relative biological effectiveness of carbon-ion irradiation in non-small cell lung carcinoma cells), ;;;;;;;, Oct. 2016, 54回, P15
• 【放射線治療-最近の話題-】放射線治療により誘導される抗腫瘍免疫と"免疫放射線療法", ;;, Nov. 2017, 62, 12, 1663
• 放射線照射により誘導される免疫チェックポイント標的分子PD-L1の発現制御機構, ;;;;;;;;;;;;;, Oct. 2017, 60回, 116
• 超解像度顕微鏡による重粒子線誘発クラスターDNA二本鎖切断の空間分布解析, ;;;;;;, Oct. 2017, 60回, 156
• 炭素イオン線特異的なDSB end resectionの解析, ;;;;, Oct. 2017, 60回, 157
• ゲノム恒常性維持機構の破綻と疾患発症の分子メカニズム　DNA二本鎖切断修復経路による免疫チェックポイント標的分子PD-L1の発現制御機構, ;;;;;;;;;;;;;, Dec. 2017, 2017年度, [3PW02
• 炭素イオン線特異的なDSB end resectionの解析, ;;;;, Dec. 2017, 2017年度, [3P
• 重粒子線に特徴的なDNA損傷の可視化と細胞運命決定に与える影響の解析, ;;;;;;, Dec. 2017, 2017年度, [4P2T14
• 放射線治療による頭頸部がん治療成績改善の取り組みと展望　放射線治療により誘導される抗腫瘍免疫と,免疫チェックポイント阻害剤との併用療法, ;;;, May 2018, 44, 2, 98
• 遠隔転移を有する前立腺癌の局所に対する症状の緩和・予防目的の放射線治療, ;;;;;;;;;;, Jun. 2018, 13, Suppl., S382
• 去勢抵抗性前立腺癌における放射線抵抗性機序の検討, ;;;;;;;;;, Apr. 2018, 106回, OP
• 【顎口腔・歯科領域の画像診断と放射線治療】口腔癌領域における放射線治療に役立つ知識　口腔癌に対する重粒子線治療, ;;;;;;;;;;, Nov. 2018, 34, 11, 1331
• varian RT REPORT　がん医療における放射線治療最前線(No.1)　免疫放射線治療の理論的背景と現状・今後の可能性, ;;;;;, Dec. 2018, 34, 1, 84
• 重粒子線誘発DSBクラスター領域でのDNA end resection促進機構の解明, ;;;;;;, Nov. 2018, 61回, 46
• 【がんにおけるPD-L1分子の発現調節】放射線治療とPD-L1発現, ;;;;, May 2019, 46, 5, 845
• 前立腺癌に対する重粒子線治療の前向き観察研究, ;;;;;;;;, Apr. 2019, 107回, OP
• ハイリスク前立腺がん:最新の治療法の使い分け　群馬大学における高リスク前立腺癌に対する重粒子線治療, ;;;;;;;;;;;, Jun. 2019, 32, 臨増, 631
• 群馬大学における前立腺癌に対する重粒子線治療, ;;;;;;;;;;;;;;, Oct. 2019, 57回, P107
• DNA損傷が惹起するHLAクラスIの抗原提示の分子機構, ;;;;;;;;;;;;, Mar. 2022, 142年会, 28L
• 子宮頸癌における腫瘍遺伝子変異量と放射線治療成績の関連解析, ;;;;;, Jul. 2022, 64回, 190
• 【がん免疫療法の最前線】免疫チェックポイント阻害薬と他の抗がん治療の併用　特に放射線治療との併用について, ;;;;, Apr. 2020, 36, 4, 451
• 群馬大学における頭頸部非扁平上皮癌に対する重粒子線治療の長期成績, ;;;;;;;;;;;;;;, Jul. 2020, 46, 2, 161
• 【進行期肺癌治癒への道-がんゲノム医療と免疫プレシジョン医療の接点】免疫チェックポイント阻害薬の進化:複合免疫療法　放射線治療とPD-1阻害薬の効果, ;, Aug. 2020, 68, 3, 420
• 免疫放射線療法　放射線治療と免疫チェックポイント阻害剤併用の現状と課題, 佐藤 浩央, Oct. 2020, 56回, S35
• 群馬大学重粒子線医学センターにおける高リスク前立腺癌に対する重粒子線治療, ;;;;;;;;;;;;;;, Oct. 2020, 58回, P
• イオン線照射後の核安定性に関する分析(Analysis of nucleolus stability after ionizing irradiation), ;;;;;, Nov. 2019, 62回, 44
• がん免疫応答を制御するDNA修復応答の解明, 佐藤 浩央, Dec. 2020, 34, 1
• 限局前立腺癌治療～エビデンスと私のこだわり～　放射線外照射(粒子線治療含む), ;;;;;;;;;;, Dec. 2020, 108回, 306
• 膀胱浸潤前立腺癌に対する重粒子線治療の検討, ;;;;;;;, Dec. 2020, 108回, 1344
• がん免疫と放射線治療(基礎と臨床)　新たながん治療戦略としての放射線治療と免疫チェックポイント阻害剤の併用(An anti-tumor immunity and radiation: basic and clinicalresearch　Combination of radiotherapy and immune checkpoint inhibitor as a novel cancer treatment strategy), 佐藤 浩央, Oct. 2020, 63回, 14
• 群馬大学における頭頸部非扁平上皮癌に対する重粒子線治療, ;;;;;;;;;;;;;;;, Apr. 2021, 47, 1, 53
• 群馬大学における前立腺癌に対する重粒子線治療, ;;;;;;;;;;;;, Dec. 2021, 109回, PP34
• DNA損傷が惹起するHLAクラスIの抗原提示の分子機構, ;;;;;;;;;;;;, Mar. 2022, 142年会, 28L
• 子宮頸癌における腫瘍遺伝子変異量と放射線治療成績の関連解析, ;;;;;, Jul. 2022, 64回, 190
• 放射線照射により促進されるパイオニアラウンド翻訳を介したHLAクラスIの提示(Ionizing radiation promotes HLA class I presentation by stimulating a pioneer round of translation associated antigen production), ;;;;;;;;;;;;, Sep. 2022, 65回, 48
• DNA損傷が惹起するパイオニアラウンド翻訳を介したHLAクラスIの抗原提示, ;;;;;;;;;;;;, Nov. 2022, 95回, 3T12a
• 免疫療法時代における局所療法の意義　放射線治療と免疫チェックポイント阻害剤併用の臨床応用に向けた現状と課題, 佐藤 浩央, Oct. 2020, 58回, SY9

MISC

• 肺癌の気管再発に対しCyberKnifeで再照射を行った1例, 岩永 素太郎; 齋藤 淳一; 佐藤 浩央; 野田 真永; 小林 大二郎; 阿部 孝憲; 白井 克幸; 中野 隆史, Nov. 2016, The Kitakanto Medical Journal, 66, 4, 304, 305
• トモセラピーによる寡分割放射線治療と免疫細胞療法を併用した免疫放射線治療の初期経験, 吉本由哉; 吉本由哉; 村田裕人; 村田裕人; 村田和俊; 野田真永; 野田真永; 岡本雅彦; 岡本雅彦; 佐藤浩央; 大西真弘; 大西真弘; 関原哲夫; 後藤重則; 後藤重則; 神垣隆; 神垣隆; 鈴木義行; 中野隆史, 2018, 日本放射線外科学会, 9th, 20
• 術前温熱化学放射線療法が施行された直腸癌患者におけるMHC class 1発現の変化と予後, 佐藤 浩央; 鈴木 義行; 井出 宗則; 野田 真永; 安藤 謙; 尾池 貴洋; 吉本 由哉; 小此木 範之; 浅尾 高行; 中野 隆史, Sep. 2013, 日本癌治療学会誌, 48, 3, 1920, 1920
• 放射線治療により誘導される抗腫瘍免疫と"免疫放射線療法", 吉本 由哉; 佐藤 浩央; 鈴木 義行, 2017, 62, 12, 1663, 1671

  DOI
• 放射線治療による抗腫瘍免疫誘導機序, 佐藤 浩央; 吉本 由哉; 鈴木 義行, 2017, 75, 8, 1289, 1293

Presentations

• Combination of radiotherapy and immune checkpoint inhibitor as a novel cancer treatment strategy, Hiro Sato, 日本放射線影響学会 第63回大会, English, Domestic conference
• Current status and issues of radiotherapy combined with immune checkpoint inhibitor, Hiro Sato, 第56回 日本医学放射線学会 秋季臨床大会, Domestic conference
• Clinical trials of combination of radiotherapy and immune checkpoint inhibitor, Hiro Sato, The 33rd Annual Meeting of Japanese Society for Radiation Oncology, Domestic conference
• Present status and issues for clinical application of radiotherapy combined with immune checkpoint inhibitor, Hiro Sato, The 58th Annual Meeting of Japan Society of Clinical Oncology, 22 Oct. 2020, 22 Oct. 2020, 24 Oct. 2020, English, Domestic conference
• Regulation of DNA damage signal-dependent PD-L1 upregulation in cancer cells after ionizing irradiation, Hiro Sato, 2020 ASTRO Annual Meeting, 25 Oct. 2020, 25 Oct. 2020, 28 Oct. 2020, English, International conference

Awards

• Apr. 2019
• Oct. 2018
• Jul. 2018
• Best Oral Presentation Award, Sato Hiro, The 3rd FARO (Federation of Asian Organizations for Radiation Oncology) Meeting, Sep. 2018
• Excellent Presentation Award, Sato Hiro, The 7th International Society of Radiation Neurobiology Conference, Feb. 2017
• Feb. 2012
• ITCCIR Presentation Award, International Training Course on Carbon-Ion Radiotherapy (ITCCIR), Dec. 2019

Research Projects

• 2018, Principal investigator, Competitive research funding
• 2018, Principal investigator, Competitive research funding
• 2018, Principal investigator, Competitive research funding
• 2018, Principal investigator, Competitive research funding
• Apr. 2017, Mar. 2020, Competitive research funding
• Apr. 2015, Mar. 2018, Competitive research funding
• Apr. 2015, Mar. 2017, Principal investigator, Competitive research funding
• Apr. 2017, Mar. 2019, Principal investigator, Competitive research funding
• 01 Apr. 2019, 31 Mar. 2022, 19K08182
• 01 Apr. 2019, 31 Mar. 2022, 19K08195
• 01 Apr. 2018, 31 Mar. 2021, 18K07706
• Apr. 2020, Mar. 2021, Principal investigator
• Feb. 2020, Mar. 2021
• Translational Research and Immunoradiotherapy in Advanced Cancer, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2017, 31 Mar. 2020, 17K10469
• Molecular mechanism of PD-L1 upregulation in cancer cells after DNA double-strand break repair pathway following irradiation, Sato Hiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Gunma University, 01 Apr. 2017, 31 Mar. 2019, DNA damage signal-dependent PD-L1 induction was observed after X-ray irradiation and chemotherapeutic agent treatment. In addition, DNA damage signal-dependent PD-L1 expression was enhanced via Chk1 activation in Ku80 or BRCA2 knockdown cancer cells. These data revealed that Chk1 activation is important for PD-L1 induction after DNA damage. Furthermore, the STAT1 / 3-IRF1 pathway is also involved in the induction of PD-L1 expression by DNA double strand breaks. Taken together, the mechanism by which the DNA damage response is involved in the regulation of PD-L1 expression in tumor cells was elucidated., 17K16420

  対象リソースIRI
• Basic and translational study for the establishment of the immuno-radiotherapy, Suzuki Yoshiyuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Fukushima Medical University, 01 Apr. 2015, 31 Mar. 2018, By the combination therapy (immunoradiometric therapy) of radiation therapy and the therapy (immune checkpoint repressors) of immunity, I put an important point for the activation of the particularly T cell-related immunity for the purpose of the development of the new cure that aimed at the reinforcement of the local site effect of treatment and the radiation therapy for the remote metastatic focus by the activation for local and systemic antitumor immunity and targeted cytotoxic T lymphocyte and the intratumoral permeation. For a glioblastoma and cancer of the esophagus patients, I analyzed a biopsy tumor tissue by immunohistochemistry dyeing. While the in-hospital IRB is approved about this study, and the making of the graft for analysis is finished from a paraffin block and, about onset of HLA class I, T-TIL, onset of PD-L1, confirms the most suitable dyeing condition and enforces analysis now., 15K10003

  対象リソースIRI
• Anti cancer specific immune response after carbon ion irradiation, Sato Hiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Gunma University, 01 Apr. 2015, 31 Mar. 2017, I found that carbon ion radiotherapy induced high-mobility group box 1 (HMGB1) release, and T cell activation and proliferation in mice with lymphoma. HMGB1 is a member of damage-associated molecular pattern, which is released by irradiated tumor cells and trigger the activation of antigen presentation cells (APCs). APCs present the tumor-derived antigens to cytotoxic T lymphocytes, which then kill the target cells. Therefore, the present data suggested that tumor cell death by carbon ion radiotherapy elicited activation of tumor antigen specific immune response., 15K19771

  対象リソースIRI