Researcher Profile and Settings

Researcher

• Name

  Shirakawa Jun

Profile and Settings

• Name

  Shirakawa, Jun

Affiliation

• Gunma University

Education

• 2011, Yokohama City University, Graduate School of Medicine
• 2006, Tsukuba University, School of Medicine

Degree

• M.D.
• Ph.D.
• M.D.
• Ph.D.
• M.D.
• M.D.
• Ph.D., University of Tsukuba

Association Memberships

• JAPANESE SOCIETY OF EXPERIMENTAL DIABETES AND OBESITY (JSEDO)
• THE JANPANESE SOCIETY OF INTERNAL MEDICINE
• THE JAPAN ENDOCRINE SOCIETY
• JAPAN DIABETES SOCIETY

Research Experience

• 2020, 9999, Gunma University, Institute for Molecular and Cellular Regulation, Laboratory of Diabetes and Metabolic Disorders, Professor, Prof lv
• 2019, 2020, Yokohama City University, Associate prof lecturer lv
• 2017, 2019, Yokohama City University, Assistant prof lv
• 2014, 2017, Harvard Medical School, Joslin Diabetes Center, Research Fellow, Researcher postdoc lv
• 2011, 2013, Yokohama City University, Assistant Professor, Assistant prof lv
• 2009, 2011, JSPS, fellow
• 2006, 2008, Kanto Central Hpspital
• 2013, 2014, Yokohama City University, School of Medicine, Department of Endocrinology and Metabolism, Assistant Professor, Assistant prof lv

Research Activities

Research Areas

• Life sciences, Metabolism and endocrinology
• Life sciences, Nutrition and health science
• Life sciences, Pathobiochemistry
• Life sciences, Laboratory animal science
• Life sciences, Cell biology

Research Interests

• obesity
• human islets
• pancreatic beta cell
• diabetes
• endocrinology
• database analysis

Published Papers

• E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance., Jun Shirakawa; Yu Togashi; Giorgio Basile; Tomoko Okuyama; Ryota Inoue; Megan Fernandez; Mayu Kyohara; Dario F De Jesus; Nozomi Goto; Wei Zhang; Takahiro Tsuno; Tatsuya Kin; Hui Pan; Jonathan M Dreyfuss; A M James Shapiro; Peng Yi; Yasuo Terauchi; Rohit N Kulkarni, 04 Oct. 2022, Cell reports, 41, 1, 111436, 111436, Scientific journal

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• Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER., Ryota Inoue; Takahiro Tsuno; Yu Togashi; Tomoko Okuyama; Aoi Sato; Kuniyuki Nishiyama; Mayu Kyohara; Jinghe Li; Setsuko Fukushima; Tatsuya Kin; Daisuke Miyashita; Yusuke Shiba; Yoshitoshi Atobe; Hiroshi Kiyonari; Kana Bando; A M James Shapiro; Kengo Funakoshi; Rohit N Kulkarni; Yasuo Terauchi; Jun Shirakawa, 15 Jul. 2022, iScience, 25, 7, 104603, 104603, Scientific journal

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• Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes patients: A retrospective cross-sectional study., Yu Togashi; Daisuke Miyashita; Takahiro Tsuno; Ryota Inoue; Tomoko Okuyama; Mayu Kyohara; Kuniyuki Nishiyama; Masanori Arai; Kenta Kanematsu; Soichiro Kanataki; Yasuo Terauchi; Jun Shirakawa, 12 Jul. 2022, Journal of diabetes investigation, 13, 11, 1861, 1872, Scientific journal

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• The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion., Mitsuaki Sobajima; Masato Miyake; Yoshimasa Hamada; Kazue Tsugawa; Miho Oyadomari; Ryota Inoue; Jun Shirakawa; Hiroshi Arima; Seiichi Oyadomari, 16 Apr. 2022, Biochemical and biophysical research communications, 611, 165, 171, Scientific journal

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• Recent developments in Phos-tag electrophoresis for the analysis of phosphoproteins in proteomics., Hisashi Hirano; Jun Shirakawa, 22 Mar. 2022, Expert review of proteomics, 1, 12, Scientific journal

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• Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway., Jinghe Li; Ryota Inoue; Yu Togashi; Tomoko Okuyama; Aoi Satoh; Mayu Kyohara; Kuniyuki Nishiyama; Takahiro Tsuno; Daisuke Miyashita; Tatsuya Kin; A M James Shapiro; Resilind Su Ern Chew; Adrian Kee Keong Teo; Seiichi Oyadomari; Yasuo Terauchi; Jun Shirakawa, 01 Mar. 2022, Diabetes, 71, 3, 424, 439, Scientific journal

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• Validity and reliability of the Japanese version of the diabetes knowledge test among in-patients with type 2 diabetes., Taichi Minami; Jun Shirakawa; Hiroko Hiiragi; Taku Yamada; Youichi Suzuki; Shinitiro Shirabe; Hajime Maeda; Yasuo Terauchi, Mar. 2022, Journal of diabetes investigation, 13, 3, 580, 587, Scientific journal

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• Insulin regulates arginine-stimulated insulin secretion in humans., Florencia Halperin; Teresa Mezza; Ping Li; Jun Shirakawa; Rohit N Kulkarni; Allison B Goldfine, Mar. 2022, Metabolism: clinical and experimental, 128, 155117, 155117, Scientific journal

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• Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study., Mayu Kyohara; Daisuke Miyashita; Ryota Inoue; Kuniyuki Nishiyama; Takahiro Tsuno; Tomoko Okuyama; Yu Togashi; Yasuo Terauchi; Jun Shirakawa, 04 Nov. 2022, PloS one, 17, 11, e0276915, Scientific journal

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• Pancreatic β-cell fate in subjects with COVID-19., Jun Shirakawa, Dec. 2021, Journal of diabetes investigation, 12, 12, 2126, 2128, Scientific journal

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• Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study., Sakiko Terui; Ryoichi Akamatsu; Masanori Arai; Ryota Inoue; Tomoko Okuyama; Mayu Kyohara; Jinghe Li; Takahiro Tsuno; Daisuke Miyashita; Yu Togashi; Yasuo Terauchi; Jun Shirakawa, Nov. 2021, Diabetes therapy : research, treatment and education of diabetes and related disorders, 12, 11, 2873, 2889, Scientific journal

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• Translational research on human pancreatic β-cell mass expansion for the treatment of diabetes., Jun Shirakawa, Oct. 2021, Diabetology international, 12, 4, 349, 355, Scientific journal

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• Asymptomatic meningitis diagnosed by positron emission tomography in a patient with syndrome of inappropriate antidiuretic hormone secretion: a case report., Masanori Hasebe; Jun Shirakawa; Daisuke Miyashita; Rieko Kunishita; Mayu Kyohara; Tomoko Okuyama; Yu Togashi; Yasuo Terauchi, 22 Jul. 2021, Journal of medical case reports, 15, 1, 390, 390, Scientific journal

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• The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes., Ryota Inoue; Kuniyuki Nishiyama; Jinghe Li; Daisuke Miyashita; Masato Ono; Yasuo Terauchi; Jun Shirakawa, 24 Jun. 2021, Cells, 10, 7, Scientific journal

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• The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling., Tomoko Okuyama; Mayu Kyohara; Yasuo Terauchi; Jun Shirakawa, 24 Jun. 2021, International journal of molecular sciences, 22, 13, Scientific journal

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• Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice., Tomozumi Takatani; Jun Shirakawa; Kimitaka Shibue; Manoj K Gupta; Hyunki Kim; Shusheng Lu; Jiang Hu; Morris F White; Robert T Kennedy; Rohit N Kulkarni, 08 Apr. 2021, The Journal of biological chemistry, 100646, 100646, Scientific journal

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• Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells., Chutima Charoensuk; Prapaporn Jungtrakoon Thamtarana; Chutima Chanprasert; Watip Tangjittipokin; Jun Shirakawa; Yu Togashi; Kazuki Orime; Pucharee Songprakhon; Chartchai Chaichana; Zuroida Abubakar; Paweena Ouying; Jatuporn Sujjitjoon; Alessandro Doria; Nattachet Plengvidhya; Pa-Thai Yenchitsomanus, 15 Feb. 2021, Molecular and cellular endocrinology, 522, 111126, 111126, Scientific journal

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• Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes., Tomoko Okuyama; Jun Shirakawa; Takashi Nakamura; Takayo Murase; Daisuke Miyashita; Ryota Inoue; Mayu Kyohara; Yu Togashi; Yasuo Terauchi, 12 Feb. 2021, Scientific reports, 11, 1, 3768, 3768, Scientific journal

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• A case of an elderly patient with insulin-dependent diabetes and dementia receiving one basal insulin plus one bolus insulin injections a day for 6 months., Taichi Minami; Jun Shirakawa; Akiko Kameda; Yoichi Suzuki; Kaoru Watanabe; Taku Yamada; Hiroko Hiiragi; Soichiro Takeda; Mayuko Takahashi; Yasuo Terauchi, Jan. 2021, Diabetology international, 12, 1, 135, 139

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• Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane., Hao Wang; Kouichi Mizuno; Noriko Takahashi; Eri Kobayashi; Jun Shirakawa; Yasuo Terauchi; Haruo Kasai; Katsuhide Okunishi; Tetsuro Izumi, Dec. 2020, Diabetes, 69, 12, 2655, 2666, Scientific journal

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• Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells., Manoj K Gupta; Heidrun Vethe; Samir Softic; Tata Nageswara Rao; Vilas Wagh; Jun Shirakawa; Harald Barsnes; Marc Vaudel; Tomozumi Takatani; Sevim Kahraman; Masaji Sakaguchi; Rachael Martinez; Jiang Hu; Yngvild Bjørlykke; Helge Raeder; Rohit N Kulkarni, 10 Nov. 2020, Stem cell reports, 15, 5, 1067, 1079, Scientific journal

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• Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor., Tomoko Okuyama; Jun Shirakawa; Kazuki Tajima; Yoko Ino; Heidrun Vethe; Yu Togashi; Mayu Kyohara; Ryota Inoue; Daisuke Miyashita; Jinghe Li; Nozomi Goto; Taiga Ichikawa; Shingo Yamasaki; Haruka Ohnuma; Rie Takayanagi; Yayoi Kimura; Hisashi Hirano; Yasuo Terauchi, 22 Oct. 2020, International journal of molecular sciences, 21, 21, Scientific journal

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• Potential linkage between dipeptidyl peptidase-4 inhibitor use and the risk of pancreatitis/pancreatic cancer., Jun Shirakawa; Yasuo Terauchi, Jul. 2020, Journal of diabetes investigation, 11, 4, 789, 791, Scientific journal

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• Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway., Jun Shirakawa; Kazuki Tajima; Tomoko Okuyama; Mayu Kyohara; Yu Togashi; Dario F De Jesus; Giorgio Basile; Tatsuya Kin; A M James Shapiro; Rohit N Kulkarni; Yasuo Terauchi, Mar. 2020, Diabetologia, 63, 3, 577, 587, Scientific journal

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• Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality., Jun Shirakawa; Yasuo Terauchi, 28 Jan. 2020, Endocrine journal, 67, 1, 1, 8, Scientific journal

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• Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects., Mayu Kyohara; Jun Shirakawa; Tomoko Okuyama; Yu Togashi; Ryota Inoue; Jinghe Li; Daisuke Miyashita; Yasuo Terauchi, 2020, Diabetology & metabolic syndrome, 12, 83, 83, Scientific journal

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• Influence of Timing of Insulin Initiation on Long-term Glycemic Control in Japanese Patients with Type 2 Diabetes: A Retrospective Cohort Study., Takashi Miyazaki; Jun Shirakawa; Jo Nagakura; Makoto Shibuya; Mayu Kyohara; Tomoko Okuyama; Yu Togashi; Akinobu Nakamura; Yoshinobu Kondo; Shinobu Satoh; Shigeru Nakajima; Masataka Taguri; Yasuo Terauchi, 01 Dec. 2019, Internal medicine (Tokyo, Japan), 58, 23, 3361, 3367, Scientific journal

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• Drug-induced hyperglycemia in the Japanese Adverse Drug Event Report database: association of evelolimus use with diabetes., Hiromi Konishi; Jun Shirakawa; Masanori Arai; Yasuo Terauchi, 28 Jun. 2019, Endocrine journal, 66, 6, 571, 574, Scientific journal

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• Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity., Yewei Ji; Shengyi Sun; Neha Shrestha; Laurel B Darragh; Jun Shirakawa; Yuan Xing; Yi He; Bethany A Carboneau; Hana Kim; Duo An; Minglin Ma; Jose Oberholzer; Scott A Soleimanpour; Maureen Gannon; Chengyang Liu; Ali Naji; Rohit N Kulkarni; Yong Wang; Sander Kersten; Ling Qi, Jun. 2019, Nature immunology, 20, 6, 677, 686, Scientific journal

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• Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes., Prapaporn Jungtrakoon; Jun Shirakawa; Patinut Buranasupkajorn; Manoj K Gupta; Dario F De Jesus; Marcus G Pezzolesi; Aussara Panya; Timothy Hastings; Chutima Chanprasert; Christine Mendonca; Rohit N Kulkarni; Alessandro Doria, May 2019, Diabetes, 68, 5, 1084, 1093, Scientific journal

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• Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion., Abdelfattah El Ouaamari; InSug O-Sullivan; Jun Shirakawa; Giorgio Basile; Wenwei Zhang; Sandra Roger; Thomas Thomou; Shanshan Xu; Guifen Qiang; Chong Wee Liew; Rohit N Kulkarni; Terry G Unterman, 18 Jan. 2019, The Journal of biological chemistry, 294, 3, 1059, 1069, Scientific journal

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• Effects of SGLT2 Inhibition on eGFR and Glomerular and Tubular Damage Markers in Japanese Patients With Type 2 Diabetes, Hiromi Konishi; Jun Shirakawa; Kazuki Tajima; Tomoko Okuyama; Yu Togashi; Hikaru Takamine; Yoshinobu Kondo; Rieko Kunishita; Yasuo Terauchi, Oct. 2018, JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 8, 5, 106, 112, Scientific journal

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• Bullous Pemphigoid and Dipeptidyl Peptidase 4 Inhibitors: A Disproportionality Analysis Based on the Japanese Adverse Drug Event Report Database., Masanori Arai; Jun Shirakawa; Hiromi Konishi; Naoko Sagawa; Yasuo Terauchi, Sep. 2018, Diabetes care, 41, 9, e130-e132, e132

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• Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation., Hideaki Inoue; Jun Shirakawa; Yu Togashi; Kazuki Tajima; Tomoko Okuyama; Mayu Kyohara; Yui Tanaka; Kazuki Orime; Yoshifumi Saisho; Taketo Yamada; Kimitaka Shibue; Rohit N Kulkarni; Yasuo Terauchi, 20 Apr. 2018, The Journal of biological chemistry, 293, 16, 5934, 5946, Scientific journal

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• SUSTAINable management of type 2 diabetes: feasibility of use and safety of semaglutide., Jun Shirakawa; Yasuo Terauchi, Apr. 2018, Annals of translational medicine, 6, 7, 129, 129

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• A Randomized Controlled Trial of a Mini Low-Carbohydrate Diet and an Energy-Controlled Diet Among Japanese Patients With Type 2 Diabetes., Masayo Kimura; Yoshinobu Kondo; Kazutaka Aoki; Jun Shirakawa; Hiroshi Kamiyama; Kazunari Kamiko; Shigeru Nakajima; Yasuo Terauchi, Mar. 2018, Journal of clinical medicine research, 10, 3, 182, 188, Scientific journal

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• Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans., Mayu Kyohara; Jun Shirakawa; Tomoko Okuyama; Ayuko Kimura; Yu Togashi; Kazuki Tajima; Hisashi Hirano; Yasuo Terauchi, 01 Dec. 2017, Endocrinology, 158, 12, 4152, 4164, Scientific journal

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• Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation., Bente Berg Johansson; Karianne Fjeld; Marie Holm Solheim; Jun Shirakawa; Enming Zhang; Magdalena Keindl; Jiang Hu; Andreas Lindqvist; Anne Døskeland; Gunnar Mellgren; Torgeir Flatmark; Pål Rasmus Njølstad; Rohit N Kulkarni; Nils Wierup; Ingvild Aukrust; Lise Bjørkhaug, 15 Oct. 2017, Molecular and cellular endocrinology, 454, 146, 157, Scientific journal

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• Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet., Kazuki Tajima; Jun Shirakawa; Tomoko Okuyama; Mayu Kyohara; Shunsuke Yamazaki; Yu Togashi; Yasuo Terauchi, 01 Sep. 2017, American journal of physiology. Endocrinology and metabolism, 313, 3, E367-E380, Scientific journal

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• GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice., Dan Kawamori; Jun Shirakawa; Chong Wee Liew; Jiang Hu; Tomoaki Morioka; Alokesh Duttaroy; Bryan Burkey; Rohit N Kulkarni, Aug. 2017, Diabetologia, 60, 8, 1442, 1453, Scientific journal

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• Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass., J Shirakawa; D F De Jesus; R N Kulkarni, Jul. 2017, European journal of clinical nutrition, 71, 7, 896, 903, Scientific journal

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• Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906., Kazuki Tajima; Jun Shirakawa; Yu Togashi; Shunsuke Yamazaki; Tomoko Okuyama; Mayu Kyohara; Hiromi Konishi; Yasuo Terauchi, 23 Jun. 2017, Scientific reports, 7, 1, 4119, 4119, Scientific journal

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• Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets., Tomoko Okuyama; Jun Shirakawa; Hiromi Yanagisawa; Mayu Kyohara; Shunsuke Yamazaki; Kazuki Tajima; Yu Togashi; Yasuo Terauchi, 24 May 2017, Scientific reports, 7, 1, 2364, 2364, Scientific journal

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• Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation., Jun Shirakawa; Megan Fernandez; Tomozumi Takatani; Abdelfattah El Ouaamari; Prapaporn Jungtrakoon; Erin R Okawa; Wei Zhang; Peng Yi; Alessandro Doria; Rohit N Kulkarni, 04 Apr. 2017, Cell metabolism, 25, 4, 868, 882, Scientific journal

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• Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling., Jun Shirakawa; Yasuo Terauchi, Mar. 2017, Journal of diabetes investigation, 8, 2, 149, 151, Scientific journal

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• Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors., Teresa Mezza; Jun Shirakawa; Rachael Martinez; Jiang Hu; Andrea Giaccari; Rohit N Kulkarni, 07 Oct. 2016, The Journal of biological chemistry, 291, 41, 21485, 21495, Scientific journal
• Novel factors modulating human β-cell proliferation., J Shirakawa; R N Kulkarni, Sep. 2016, Diabetes, obesity & metabolism, 18 Suppl 1, 71, 7, Scientific journal

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• IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation., Tomozumi Takatani; Jun Shirakawa; Michael W Roe; Colin A Leech; Bernhard F Maier; Raghavendra G Mirmira; Rohit N Kulkarni, 05 Jul. 2016, Scientific reports, 6, 28177, 28177, Scientific journal

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• ERRγ-A New Player in β Cell Maturation., Jun Shirakawa; Rohit N Kulkarni, 10 May 2016, Cell metabolism, 23, 5, 765, 7, Scientific journal

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• Evaluation of the appropriateness of using glucometers for measuring the blood glucose levels in mice., Yu Togashi; Jun Shirakawa; Tomoko Okuyama; Shunsuke Yamazaki; Mayu Kyohara; Ayumi Miyazawa; Takafumi Suzuki; Mari Hamada; Yasuo Terauchi, 06 May 2016, Scientific reports, 6, 25465, 25465, Scientific journal

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• Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation., Ivan Achel Valdez; Ercument Dirice; Manoj K Gupta; Jun Shirakawa; Adrian Kee Keong Teo; Rohit N Kulkarni, 19 Apr. 2016, Cell reports, 15, 3, 460, 470, Scientific journal

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• Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model., Kazuki Orime; Jun Shirakawa; Yu Togashi; Kazuki Tajima; Hideaki Inoue; Yoji Nagashima; Yasuo Terauchi, 05 Feb. 2016, European journal of pharmacology, 772, 22, 32, Scientific journal

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• SerpinB1 Promotes Pancreatic β Cell Proliferation., Abdelfattah El Ouaamari; Ercument Dirice; Nicholas Gedeon; Jiang Hu; Jian-Ying Zhou; Jun Shirakawa; Lifei Hou; Jessica Goodman; Christos Karampelias; Guifeng Qiang; Jeremie Boucher; Rachael Martinez; Marina A Gritsenko; Dario F De Jesus; Sevim Kahraman; Shweta Bhatt; Richard D Smith; Hans-Dietmar Beer; Prapaporn Jungtrakoon; Yanping Gong; Allison B Goldfine; Chong Wee Liew; Alessandro Doria; Olov Andersson; Wei-Jun Qian; Eileen Remold-O'Donnell; Rohit N Kulkarni, 12 Jan. 2016, Cell metabolism, 23, 1, 194, 205, Scientific journal

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• DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid., Jun Shirakawa; Tomoko Okuyama; Mayu Kyohara; Eiko Yoshida; Yu Togashi; Kazuki Tajima; Shunsuke Yamazaki; Mitsuyo Kaji; Megumi Koganei; Hajime Sasaki; Yasuo Terauchi, 2016, Diabetology & metabolic syndrome, 8, 16, 16, Scientific journal

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• Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice., Yun-Jung Lee; Conglin Liu; Mengyang Liao; Galina K Sukhova; Jun Shirakawa; Meriem Abdennour; Karine Iamarene; Sebastien Andre; Karen Inouye; Karine Clement; Rohit N Kulkarni; Alexander S Banks; Peter Libby; Guo-Ping Shi, Nov. 2015, Endocrinology, 156, 11, 4047, 58, Scientific journal

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• Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts., Manoj K Gupta; Adrian Kee Keong Teo; Tata Nageswara Rao; Shweta Bhatt; Andre Kleinridders; Jun Shirakawa; Tomozumi Takatani; Jiang Hu; Dario F De Jesus; Rebecca Windmueller; Amy J Wagers; Rohit N Kulkarni, Oct. 2015, Stem cells translational medicine, 4, 10, 1101, 8, Scientific journal

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• Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics., Abdelfattah El Ouaamari; Jian-Ying Zhou; Chong Wee Liew; Jun Shirakawa; Ercument Dirice; Nicholas Gedeon; Sevim Kahraman; Dario F De Jesus; Shweta Bhatt; Jong-Seo Kim; Therese Rw Clauss; David G Camp 2nd; Richard D Smith; Wei-Jun Qian; Rohit N Kulkarni, 07 Aug. 2015, Journal of proteome research, 14, 8, 3111, 3122, Scientific journal

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• Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes., Shweta Bhatt; Manoj K Gupta; Mogher Khamaisi; Rachael Martinez; Marina A Gritsenko; Bridget K Wagner; Patrick Guye; Volker Busskamp; Jun Shirakawa; Gongxiong Wu; Chong Wee Liew; Therese R Clauss; Ivan Valdez; Abdelfattah El Ouaamari; Ercument Dirice; Tomozumi Takatani; Hillary A Keenan; Richard D Smith; George Church; Ron Weiss; Amy J Wagers; Wei-Jun Qian; George L King; Rohit N Kulkarni, 04 Aug. 2015, Cell metabolism, 22, 2, 239, 52, Scientific journal

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• Selective and sequential loss of transcriptional factors: A hallmark of β-cell failure in type 2 diabetes?, Jun Shirakawa; Yasuo Terauchi, Jul. 2014, Journal of diabetes investigation, 5, 4, 359, 61, Scientific journal

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• Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice., Jun Shirakawa; Tomoko Okuyama; Eiko Yoshida; Mari Shimizu; Yuka Horigome; Takayuki Tuno; Moe Hayasaka; Shiori Abe; Masahiro Fuse; Yu Togashi; Yasuo Terauchi, Jun. 2014, Endocrinology, 155, 6, 2102, 11, Scientific journal

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• β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice., Yu Togashi; Jun Shirakawa; Kazuki Orime; Mitsuyo Kaji; Eri Sakamoto; Kazuki Tajima; Hideaki Inoue; Akinobu Nakamura; Yoshihiro Tochino; Yoshio Goshima; Iichiro Shimomura; Yasuo Terauchi, May 2014, Endocrinology, 155, 5, 1643, 52, Scientific journal

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• Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy., Jun Shirakawa; Yuko Murohashi; Noriko Okazaki; Shunsuke Yamazaki; Tetsuya Tamura; Tomoko Okuyama; Yu Togashi; Yasuo Terauchi, 2014, Endocrine journal, 61, 11, 1115, 23, Scientific journal
• Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice., K Tajima; A Nakamura; J Shirakawa; Y Togashi; K Orime; K Sato; H Inoue; M Kaji; E Sakamoto; Y Ito; K Aoki; Y Nagashima; T Atsumi; Y Terauchi, 15 Oct. 2013, American journal of physiology. Endocrinology and metabolism, 305, 8, E987-98, Scientific journal

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• Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells., Jun Shirakawa; Yu Togashi; Eri Sakamoto; Mitsuyo Kaji; Kazuki Tajima; Kazuki Orime; Hideaki Inoue; Naoto Kubota; Takashi Kadowaki; Yasuo Terauchi, Oct. 2013, Diabetes, 62, 10, 3448, 58, Scientific journal

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• Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation., Kazuki Orime; Jun Shirakawa; Yu Togashi; Kazuki Tajima; Hideaki Inoue; Yuzuru Ito; Koichiro Sato; Akinobu Nakamura; Kazutaka Aoki; Yoshio Goshima; Yasuo Terauchi, Jan. 2013, Endocrinology, 154, 1, 54, 64, Scientific journal

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• AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration., Kazuki Tajima; Jun Shirakawa; Yu Togashi; Hideaki Inoue; Koichiro Sato; Kazuki Orime; Yuzuru Ito; Mitsuyo Kaji; Eri Sakamoto; Akinobu Nakamura; Kazutaka Aoki; Yoshio Goshima; Tatsuya Atsumi; Yasuo Terauchi, 2013, PloS one, 8, 5, e64633, Scientific journal

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• Non-Alcoholic Fatty Liver Disease Adversely Affects the Glycemic Control Afforded by Sitagliptin, Tomoyuki Iwasaki; Wataru Tomeno; Masato Yoneda; Masahiko Inamori; Jun Shirakawa; Kento Imajo; Keigo Kawashima; Yasuo Terauchi; Atsushi Nakajima, Jul. 2012, HEPATO-GASTROENTEROLOGY, 59, 117, 1522, 1525, Scientific journal

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• Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes., Jun Shirakawa; Yu Togashi; Kazuki Tajima; Kazuki Orime; Kaori Kikuchi; Takashi Miyazaki; Koichiro Sato; Mari Kimura; Yoshio Goshima; Yasuo Terauchi, Jul. 2012, Diabetes research and clinical practice, 97, 1, e9-12, Scientific journal

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• Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice., Jun Shirakawa; Ritsuko Tanami; Yu Togashi; Kazuki Tajima; Kazuki Orime; Naoto Kubota; Takashi Kadowaki; Yoshio Goshima; Yasuo Terauchi, Jul. 2012, Endocrinology, 153, 7, 3066, 75, Scientific journal

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• Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions., A Nakamura; Y Togashi; K Orime; K Sato; J Shirakawa; M Ohsugi; N Kubota; T Kadowaki; Y Terauchi, Jun. 2012, Diabetologia, 55, 6, 1745, 54, Scientific journal

  DOI
• [Glucokinase activators]., Jun Shirakawa; Yasuo Terauchi, May 2012, Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 3, 721, 7, Scientific journal
• Impact of the dipeptidyl peptidase-4 inhibitor vildagliptin on glucose tolerance and β-cell function and mass in insulin receptor substrate-2-knockout mice fed a high-fat diet., Koichiro Sato; Akinobu Nakamura; Jun Shirakawa; Tomonori Muraoka; Yu Togashi; Kazuaki Shinoda; Kazuki Orime; Naoto Kubota; Takashi Kadowaki; Yasuo Terauchi, Mar. 2012, Endocrinology, 153, 3, 1093, 102, Scientific journal

  DOI
• Double-blind randomized clinical trial of the effects of ezetimibe on postprandial hyperlipidaemia and hyperglycaemia., Kaori Kikuchi; Uru Nezu; Koji Inazumi; Takashi Miyazaki; Kanako Ono; Kazuki Orime; Jun Shirakawa; Koichiro Sato; Hirofumi Koike; Tadashi Wakasugi; Misako Sato; Chihiro Kawakami; Shinichiro Watanabe; Tadashi Yamakawa; Yasuo Terauchi, 2012, Journal of atherosclerosis and thrombosis, 19, 12, 1093, 101, Scientific journal
• Sitagliptin as a Novel Treatment Agent for Non-Alcoholic Fatty Liver Disease Patients with Type 2 Diabetes Mellitus, Tomoyuki Iwasaki; Masato Yoneda; Masahiko Inamori; Jun Shirakawa; Takuma Higurashi; Shin Maeda; Yasuo Terauchi; Atsushi Nakajima, Nov. 2011, HEPATO-GASTROENTEROLOGY, 58, 112, 2103, 2105, Scientific journal

  DOI
• Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes., Jun Shirakawa; Kikuko Amo; Hirokazu Ohminami; Kazuki Orime; Yu Togashi; Yuzuru Ito; Kazuki Tajima; Megumi Koganei; Hajime Sasaki; Eiji Takeda; Yasuo Terauchi, 22 Jul. 2011, The Journal of biological chemistry, 286, 29, 25467, 76, Scientific journal

  DOI
• Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice., Jun Shirakawa; Hideki Fujii; Kei Ohnuma; Koichiro Sato; Yuzuru Ito; Mitsuyo Kaji; Eri Sakamoto; Megumi Koganei; Hajime Sasaki; Yoji Nagashima; Kikuko Amo; Kazutaka Aoki; Chikao Morimoto; Eiji Takeda; Yasuo Terauchi, Apr. 2011, Diabetes, 60, 4, 1246, 57, Scientific journal

  DOI
• Correlations of fasting and postprandial blood glucose increments to the overall diurnal hyperglycemic status in type 2 diabetic patients: variations with levels of HbA1c., Kaori Kikuchi; Uru Nezu; Jun Shirakawa; Koichiro Sato; Yu Togashi; Taisuke Kikuchi; Kazutaka Aoki; Yuzuru Ito; Mari Kimura; Yasuo Terauchi, 2010, Endocrine journal, 57, 3, 259, 66, Scientific journal
• Comparison of pre- versus post-meal administration of voglibose in men with or without impaired glucose tolerance., Kazutaka Aoki; Yuzuru Ito; Kaori Saito; Jun Shirakawa; Yu Togashi; Kouichiro Satoh; Tomonori Muraoka; Kazuaki Shinoda; Kiyomi Masuda; Mari Kimura; Yasuo Terauchi, Feb. 2009, Diabetes research and clinical practice, 83, 2, e31-2

  DOI
• Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy., Jun Shirakawa; Tohru Takeshita; Mariko Miyao; Satoshi Orimo; Yasuo Terauchi; Yuzo Mizuno, 2009, Internal medicine (Tokyo, Japan), 48, 6, 441, 6, Scientific journal
• LFA-1 decreases the antigen dose for T cell activation in vivo., Yinan Wang; Kazuko Shibuya; Yumi Yamashita; Jun Shirakawa; Kai Shibata; Hirayasu Kai; Tadashi Yokosuka; Takashi Saito; Shin-ichiro Honda; Satoko Tahara-Hanaoka; Akira Shibuya, Sep. 2008, International immunology, 20, 9, 1119, 27, Scientific journal

  DOI
• LFA-1-dependent lipid raft recruitment of DNAM-1 (CD226) in CD4+ T cell., Jun Shirakawa; Yinan Wang; Satoko Tahara-Hanaoka; Shin-ichiro Honda; Kazuko Shibuya; Akira Shibuya, Jun. 2006, International immunology, 18, 6, 951, 7, Scientific journal
• Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226)., Jun Shirakawa; Kazuko Shibuya; Akira Shibuya, Mar. 2005, International immunology, 17, 3, 217, 23, Scientific journal
• CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation., Kazuko Shibuya; Jun Shirakawa; Tomie Kameyama; Shin-Ichiro Honda; Satoko Tahara-Hanaoka; Akitomo Miyamoto; Masafumi Onodera; Takayuki Sumida; Hiromitsu Nakauchi; Hiroyuki Miyoshi; Akira Shibuya, 15 Dec. 2003, The Journal of experimental medicine, 198, 12, 1829, 39, Scientific journal
• A disproportionality analysis of the adverse effect profiles of methimazole and propylthiouracil in patients with hyperthyroidism using the Japanese Adverse Drug Event Report Database., Masanori Arai; Takahiro Tsuno; Hiromi Konishi; Kuniyuki Nishiyama; Yasuo Terauchi; Ryota Inoue; Jun Shirakawa, 02 May 2023, Thyroid : official journal of the American Thyroid Association, Scientific journal

  DOI
• Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model., Ayako Fukunaka; Mari Shimura; Takayuki Ichinose; Ofejiro B Pereye; Yuko Nakagawa; Yasuko Tamura; Wakana Mizutani; Ryota Inoue; Takato Inoue; Yuto Tanaka; Takashi Sato; Tatsuya Saitoh; Toshiyuki Fukada; Yuya Nishida; Takeshi Miyatsuka; Jun Shirakawa; Hirotaka Watada; Satoshi Matsuyama; Yoshio Fujitani, 15 Mar. 2023, Scientific reports, 13, 1, 3484, 3484, Scientific journal

  DOI
• Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes., Daisuke Miyashita; Ryota Inoue; Takahiro Tsuno; Tomoko Okuyama; Mayu Kyohara; Chigusa Nakahashi-Oda; Kuniyuki Nishiyama; Setsuko Fukushima; Yutaro Inada; Yu Togashi; Akira Shibuya; Yasuo Terauchi; Jun Shirakawa, 22 Dec. 2022, iScience, 25, 12, 105662, 105662, Scientific journal

  DOI
• Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion., Sohyun Moon; Lamyaa Alsarkhi; Tai-Tu Lin; Ryota Inoue; Azeddine Tahiri; Cecilia Colson; Weikang Cai; Jun Shirakawa; Wei-Jun Qian; Jerry Yingtao Zhao; Abdelfattah El Ouaamari, Oct. 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37, 10, e23185, Scientific journal

  DOI
• Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice., Kuniyuki Nishiyama; Masato Ono; Takahiro Tsuno; Ryota Inoue; Ayako Fukunaka; Tomoko Okuyama; Mayu Kyohara; Yu Togashi; Setsuko Fukushima; Takuto Atsumi; Aoi Sato; Asuka Tsurumoto; Chisato Sakai; Yoshio Fujitani; Yasuo Terauchi; Shuichi Ito; Jun Shirakawa, 14 Jun. 2023, Endocrinology, 164, 8, Scientific journal

  DOI
• Encapsulated human islets in alginate fiber maintain long-term functionality., Junko Nishida; Takahiro Tsuno; Shigeharu G Yabe; Tatsuya Kin; Satsuki Fukuda; Fujie Takeda; Jun Shirakawa; Hitoshi Okochi, 28 Mar. 2024, Endocrine journal, 71, 3, 253, 264, Scientific journal

  DOI
• Immediate Impact of Switching from Dipeptidyl Peptidase 4 (DPP4) Inhibitors to Low-Dose (0.3 mg) Liraglutide on Glucose Profiles: A Retrospective Observational Study., Sakiko Terui; Mari Igari; Takahiro Tsuno; Tomoko Okuyama; Ryota Inoue; Mayu Kyohara; Yasuo Terauchi; Jun Shirakawa, 18 Mar. 2024, Diabetes therapy : research, treatment and education of diabetes and related disorders, Scientific journal

  DOI
• Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes., Jun Shirakawa, Jun. 2023, Journal of diabetes investigation, 14, 6, 735, 740, Scientific journal

  DOI
• Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets., Mayu Kyohara; Rie Takayanagi; Takahiro Tsuno; Esther Ong Yajima; Ryota Inoue; Naoya Yamashita; Tomoko Okuyama; Kuniyuki Nishiyama; Kohichi Matsunaga; Emi Ishida; Shuichi Ito; Yasuo Terauchi; Yoshio Goshima; Jun Shirakawa, 27 Mar. 2025, Scientific reports, 15, 1, 10546, 10546, Scientific journal

  DOI
• The antitumor effects of metformin are potentially mediated through LPA receptor inhibition., Koichi Sato; Hideaki Ogasawara; Yuichi Ikeda; Hidetoshi Kumagai; Ryota Inoue; Takahiro Tsuno; Koichi Matsunaga; Emi Ishida; Jun Shirakawa, 10 Mar. 2025, Diabetes research and clinical practice, 222, 112094, 112094, Scientific journal

  DOI
• The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner., Tomoko Okuyama; Takahiro Tsuno; Ryota Inoue; Setsuko Fukushima; Mayu Kyohara; Anzu Matsumura; Daisuke Miyashita; Kuniyuki Nishiyama; Yusuke Takano; Yu Togashi; Makiko Meguro-Horike; Shin-Ichi Horike; Tatsuya Kin; A M James Shapiro; Hiromi Yanagisawa; Yasuo Terauchi; Jun Shirakawa, 21 Feb. 2025, iScience, 28, 2, 111856, 111856, Scientific journal

  DOI
• Vagal sensory neuron-derived FGF3 controls insulin secretion., Azeddine Tahiri; Ayman Youssef; Ryota Inoue; Sohyun Moon; Lamyaa Alsarkhi; Laila Berroug; Xuan Thi Anh Nguyen; Le Wang; Hyokjoon Kwon; Zhiping P Pang; Jerry Yingtao Zhao; Jun Shirakawa; Luis Ulloa; Abdelfattah El Ouaamari, 06 Jan. 2025, Developmental cell, 60, 1, 51, 61, Scientific journal

  DOI
• Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle., Masahiko Honda; Ryota Inoue; Kuniyuki Nishiyama; Takeshi Ueda; Akiyoshi Komuro; Hisayuki Amano; Ryoichi Sugisawa; Suman Dash; Jun Shirakawa; Hitoshi Okada, 17 Sep. 2024, Journal of cellular physiology, e31436, Scientific journal

  DOI
• Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects, Kyohara, Mayu;Shirakawa, Jun;Okuyama, Tomoko;Togashi, Yu;Inoue, Ryota;Li, Jinghe;Miyashita, Daisuke;Terauchi, Yasuo, 2020, DIABETOLOGY & METABOLIC SYNDROME, 12, 1

  DOI
• Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor, Okuyama, Tomoko;Shirakawa, Jun;Tajima, Kazuki;Ino, Yoko;Vethe, Heidrun;Togashi, Yu;Kyohara, Mayu;Inoue, Ryota;Miyashita, Daisuke;Li, Jinghe;Goto, Nozomi;Ichikawa, Taiga;Yamasaki, Shingo;Ohnuma, Haruka;Takayanagi, Rie;Kimura, Yayoi;Hirano, Hisashi;Terauchi, Yasuo, 2020, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21, 21

  DOI
• Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane, Wang, Hao;Mizuno, Kouichi;Takahashi, Noriko;Kobayashi, Eri;Shirakawa, Jun;Terauchi, Yasuo;Kasai, Haruo;Okunishi, Katsuhide;Izumi, Tetsuro, 2020, DIABETES, 69, 12, 2655, 2666

  DOI
• Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells, Charoensuk, Chutima;Thamtarana, Prapaporn Jungtrakoon;Chanprasert, Chutima;Tangjittipokin, Watip;Shirakawa, Jun;Togashi, Yu;Orime, Kazuki;Songprakhon, Pucharee;Chaichana, Chartchai;Abubakar, Zuroida;Ouying, Paweena;Sujjitjoon, Jatuporn;Doria, Alessandro;Plengvidhya, Nattachet;Yenchitsomanus, Pa-thai, 2021, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 522

  DOI
• Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes, Okuyama, Tomoko;Shirakawa, Jun;Nakamura, Takashi;Murase, Takayo;Miyashita, Daisuke;Inoue, Ryota;Kyohara, Mayu;Togashi, Yu;Terauchi, Yasuo, 2021, SCIENTIFIC REPORTS, 11, 1

  DOI
• The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling, Okuyama, Tomoko;Kyohara, Mayu;Terauchi, Yasuo;Shirakawa, Jun, 2021, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22, 13

  DOI
• Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice, Takatani, Tomozumi;Shirakawa, Jun;Shibue, Kimitaka;Gupta, Manoj K.;Kim, Hyunki;Lu, Shusheng;Hu, Jiang;White, Morris F.;Kennedy, Robert T.;Kulkarni, Rohit N., 2021, JOURNAL OF BIOLOGICAL CHEMISTRY, 296

  DOI
• The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes, Inoue, Ryota;Nishiyama, Kuniyuki;Li, Jinghe;Miyashita, Daisuke;Ono, Masato;Terauchi, Yasuo;Shirakawa, Jun, 2021, CELLS, 10, 7

  DOI
• Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study, Terui, Sakiko;Akamatsu, Ryoichi;Arai, Masanori;Inoue, Ryota;Okuyama, Tomoko;Kyohara, Mayu;Li, Jinghe;Tsuno, Takahiro;Miyashita, Daisuke;Togashi, Yu;Terauchi, Yasuo;Shirakawa, Jun, 2021, DIABETES THERAPY, 12, 11, 2873, 2889

  DOI
• Pancreatic beta-cell fate in subjects with COVID-19, Shirakawa, Jun, 2021, JOURNAL OF DIABETES INVESTIGATION, 12, 12, 2126, 2128

  DOI
• Validity and reliability of the Japanese version of the diabetes knowledge test among in-patients with type 2 diabetes, Minami, Taichi;Shirakawa, Jun;Hiiragi, Hiroko;Yamada, Taku;Suzuki, Youichi;Shirabe, Shinitiro;Maeda, Hajime;Terauchi, Yasuo, 2022, JOURNAL OF DIABETES INVESTIGATION, 13, 3, 580, 587

  DOI
• Insulin regulates arginine-stimulated insulin secretion in humans, Halperin, Florencia;Mezza, Teresa;Li, Ping;Shirakawa, Jun;Kulkarni, Rohit N.;Goldfine, Allison B., 2022, METABOLISM-CLINICAL AND EXPERIMENTAL, 128

  DOI
• Recent developments in Phos-tag electrophoresis for the analysis of phosphoproteins in proteomics, Hirano, Hisashi;Shirakawa, Jun, 2022, EXPERT REVIEW OF PROTEOMICS, 19, 2, 103, 114

  DOI
• Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER, Inoue, Ryota;Tsuno, Takahiro;Togashi, Yu;Okuyama, Tomoko;Sato, Aoi;Nishiyama, Kuniyuki;Kyohara, Mayu;Li, Jinghe;Fukushima, Setsuko;Kin, Tatsuya;Miyashita, Daisuke;Shiba, Yusuke;Atobe, Yoshitoshi;Kiyonari, Hiroshi;Bando, Kana;Shapiro, A. M. James;Funakoshi, Kengo;Kulkarni, Rohit N.;Terauchi, Yasuo;Shirakawa, Jun, 2022, ISCIENCE, 25, 7

  DOI
• Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes patients: A retrospective cross-sectional study, Togashi, Yu;Miyashita, Daisuke;Tsuno, Takahiro;Inoue, Ryota;Okuyama, Tomoko;Kyohara, Mayu;Nishiyama, Kuniyuki;Arai, Masanori;Kanematsu, Kenta;Kanataki, Soichiro;Terauchi, Yasuo;Shirakawa, Jun, 2022, JOURNAL OF DIABETES INVESTIGATION, 13, 11, 1861, 1872

  DOI
• The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion, Sobajima, Mitsuaki;Miyake, Masato;Hamada, Yoshimasa;Tsugawa, Kazue;Oyadomari, Miho;Inoue, Ryota;Shirakawa, Jun;Arima, Hiroshi;Oyadomari, Seiichi, 2022, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 611, 165, 171

  DOI
• E2F1 transcription factor mediates a link between fat and islets to promote ? cell proliferation in response to acute insulin resistance, Shirakawa, Jun;Togashi, Yu;Basile, Giorgio;Okuyama, Tomoko;Inoue, Ryota;Fernandez, Megan;Kyohara, Mayu;De Jesus, Dario F.;Goto, Nozomi;Zhang, Wei;Tsuno, Takahiro;Kin, Tatsuya;Pan, Hui;Dreyfuss, Jonathan M.;Shapiro, A. M. James;Yi, Peng;Terauchi, Yasuo;Kulkarni, Rohit N., 2022, CELL REPORTS, 41, 1

  DOI
• Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway, Li, Jinghe;Inoue, Ryota;Togashi, Yu;Okuyama, Tomoko;Satoh, Aoi;Kyohara, Mayu;Nishiyama, Kuniyuki;Tsuno, Takahiro;Miyashita, Daisuke;Kin, Tatsuya;Shapiro, A. M. James;Chew, Resilind Su Ern;Teo, Adrian Kee Keong;Oyadomari, Seiichi;Terauchi, Yasuo;Shirakawa, Jun, 2022, DIABETES, 71, 3, 424, 439

  DOI
• Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes, Miyashita, Daisuke;Inoue, Ryota;Tsuno, Takahiro;Okuyama, Tomoko;Kyohara, Mayu;Nakahashi-Oda, Chigusa;Nishiyama, Kuniyuki;Fukushima, Setsuko;Inada, Yutaro;Togashi, Yu;Shibuya, Akira;Terauchi, Yasuo;Shirakawa, Jun, 2022, ISCIENCE, 25, 12

  DOI
• Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study, Kyohara, Mayu;Miyashita, Daisuke;Inoue, Ryota;Nishiyama, Kuniyuki;Tsuno, Takahiro;Okuyama, Tomoko;Togashi, Yu;Terauchi, Yasuo;Shirakawa, Jun, 2022, PLOS ONE, 17, 11

  DOI
• Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes, Shirakawa, Jun, 2023, JOURNAL OF DIABETES INVESTIGATION, 14, 6, 735, 740

  DOI
• Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model, Fukunaka, Ayako;Shimura, Mari;Ichinose, Takayuki;Pereye, Ofejiro B.;Nakagawa, Yuko;Tamura, Yasuko;Mizutani, Wakana;Inoue, Ryota;Inoue, Takato;Tanaka, Yuto;Sato, Takashi;Saitoh, Tatsuya;Fukada, Toshiyuki;Nishida, Yuya;Miyatsuka, Takeshi;Shirakawa, Jun;Watada, Hirotaka;Matsuyama, Satoshi;Fujitani, Yoshio, 2023, SCIENTIFIC REPORTS, 13, 1

  DOI
• A Disproportionality Analysis of the Adverse Effect Profiles of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Using the Japanese Adverse Drug Event Report Database, Arai, Masanori;Tsuno, Takahiro;Konishi, Hiromi;Nishiyama, Kuniyuki;Terauchi, Yasuo;Inoue, Ryota;Shirakawa, Jun, 2023, THYROID, 33, 7, 804, 816

  DOI
• Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice, Nishiyama, Kuniyuki;Ono, Masato;Tsuno, Takahiro;Inoue, Ryota;Fukunaka, Ayako;Okuyama, Tomoko;Kyohara, Mayu;Togashi, Yu;Fukushima, Setsuko;Atsumi, Takuto;Sato, Aoi;Tsurumoto, Asuka;Sakai, Chisato;Fujitani, Yoshio;Terauchi, Yasuo;Ito, Shuichi;Shirakawa, Jun, 2023, ENDOCRINOLOGY, 164, 8

  DOI
• Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion, Moon, Sohyun;Alsarkhi, Lamyaa;Lin, Tai-Tu;Inoue, Ryota;Tahiri, Azeddine;Colson, Cecilia;Cai, Weikang;Shirakawa, Jun;Qian, Wei-Jun;Zhao, Jerry Yingtao;El Ouaamari, Abdelfattah, 2023, FASEB JOURNAL, 37, 10

  DOI
• Human islets for research: progress, challenges, and suggestions, Shirakawa Jun, 2021, Organ Biology, 28, 2, 113, 120

  DOI
• Phos-tag diagonal electrophoresis to analyze phosphoproteins, Hirano Hisashi;Shirakawa Jun, 2021, Electrophoresis Letters, 65, 2, 51, 62

  DOI
• Translational Research on Human Pancreatic β cell Mass Expansion for the Treatment of Diabetes, Shirakawa Jun, Jan. 2022, Journal of the Japan Diabetes Society, 65, 1, 20, 22

  DOI
• 【モデル動物を用いた糖尿病・肥満症研究による病態解明と治療法開発】インスリンシグナルに非依存的な液性因子を介した膵β細胞増殖機構, 白川 純, Oct. 2020, 51, 4, 260
• 【糖尿病治療・研究の最前線2021】基礎研究　膵β細胞量調節の分子機構, ;;, Jan. 2021, 276, 5, 371
• ヒト膵島を用いた糖尿病根本治療へ向けたトランスレーショナルリサーチ, 白川 純, Oct. 2020, 71, 4, 581
• 膵β細胞でのUCP2を介したアルドラーゼB発現上昇が2型糖尿病におけるインスリン分泌障害を惹起する, ;;;;;, Apr. 2021, 97, 1, 243
• Semaphorin関連分子群の膵島における遺伝子発現の検討, ;;;, Apr. 2021, 97, 1, 320
• ERストレス誘発β細胞アポトーシスに対するイメグリミンの保護作用(Protective effects of imeglimin on ER stress-induced β cell apoptosis), ;;;;;;, Apr. 2021, 97, 1, 321
• 膵β細胞の発生,分化と量の調節機構　培養ヒト膵島を用いた膵β細胞機能と膵β細胞量の制御機構の解析, 白川 純, May 2021, 64, Suppl.1, S13
• ヒト膵島におけるUCP2およびアルドラーゼBがインスリン分泌に与える影響の検討, ;;;;;, May 2021, 64, Suppl.1, I
• Prodynorphinの膵島における発現変化の検討, ;;;;;;, May 2021, 64, Suppl.1, I
• 【ヒト組織の研究利用-わが国の現状俯瞰と膵島研究の展望】ヒト膵島の研究転用の意義と課題　本邦での実現を見据えて, 白川 純, Jul. 2021, 28, 2, 113
• 保険適用となった膵島移植と今後の展望　日本人ヒト膵島の研究転用の意義と課題, 白川 純, Sep. 2021, 56, 総会臨時, SWS4
• 生体分子解析の技術革新と生命・医科学研究への応用　リン酸化タンパク質解析のためのPhos-tag対角線電気泳動, ;, Aug. 2021, 65, 2, 51
• 幹細胞・膵島再生研究と展望, ;, Jan. 2022, 54, 1, 74
• 新規糖尿病治療薬イメグリミン, 白川 純, Mar. 2022, 140, 3, 284
• プロトン感知性受容体TDAG8はマウス脳虚血モデルの脳損傷において抑制的に働く, ;;;, Nov. 2021, 94回, [3T13a
• 膵臓内分泌細胞の最前線　液性因子を介した膵β細胞増殖促進機構の新機軸, 白川 純, Apr. 2022, 98, 1, 182
• Imegliminは小胞体ストレスによるアポトーシスからβ細胞を保護する(Imeglimin protects β-cells against endoplasmic reticulum stress-induced apoptosis), ;;, Apr. 2022, 98, 1, 286
• 新時代における分子糖尿病学　糖尿病の合併症予防へ向けた分子機序からのアプローチ, 白川 純, Apr. 2022, 65, Suppl.1, S
• 分子糖尿病学研究へのいざない　UCP2およびアルドラーゼBによる膵β細胞障害機構の解明, ;;, Apr. 2022, 65, Suppl.1, S
• 膵β細胞障害過程におけるUCP2によるAldB誘導機構の解析, ;;;;;, Apr. 2022, 65, Suppl.1, S
• Imegliminは小胞体ホメオスタシス経路調節によりβ細胞生存を促進する(Imeglimin promotes β-cell survival by modulating the endoplasmic reticulum homeostasis pathway), ;;, Apr. 2022, 65, Suppl.1, S
• 膵島においてグルコースにより誘導されるProdynorphinの糖代謝への影響, ;;;;;;, Apr. 2022, 65, Suppl.1, S
• 金属刺激によるヒト気道平滑筋細胞のインターロイキン-6産生とプロトン感知性OGR1受容体の関与, ;;;;;, Nov. 2022, 95回, 3T12a
• 糖毒性下におけるUCP2およびアルドラーゼBを介した膵β細胞障害機構の解明, ;;, Apr. 2023, 58回, 44
• 膵島の膵α細胞における機能的不均一性の探索, ;;;, Apr. 2023, 58回, 53
• 糖尿病下の膵島で増加するアルドラーゼBの膵β細胞における機能解析, ;;, May 2023, 99, 1, 305
• 膵島研究(再生,移植,インスリン分泌)の現状と展望　急性インスリン抵抗性に対する膵β細胞量の代償性増大機構, 白川 純, Apr. 2023, 66, Suppl.1, S
• 経口血糖降下薬の新展開　イメグリミン, 白川 純, Apr. 2023, 66, Suppl.1, S
• インスリン抵抗性に応答する代償性β細胞複製のメカニズム(Mechanisms underlying compensatory β cell replication in response to insulin resistance), 白川 純, Apr. 2023, 66, Suppl.1, S
• 2型糖尿病ヒト膵島で発現上昇するアルドラーゼBの膵β細胞における作用の解析, ;;, Apr. 2023, 66, Suppl.1, S
• 肥満糖尿病db/dbマウスにおけるimegliminとmetforminの併用による膵β細胞保護効果の検討, ;;;;;;;, Apr. 2023, 66, Suppl.1, S
• 膵島のMulti electrode array(MEA:微小電極アレイ)を用いた生理機能の解析, ;;;;, Apr. 2023, 66, Suppl.1, S
• ヒト型糖尿病モデルマウスの膵島における金属動態変化, ;;;;;;;, Apr. 2023, 66, Suppl.1, S
• Imegliminの膵α細胞機能や遺伝子発現への影響の解析, ;;;;;, Apr. 2023, 66, Suppl.1, S
• ヒト膵島を用いた糖尿病治療研究の基盤形成, 白川 純, Dec. 2023, 37, 1
• 【患者の将来を見据えた実践的糖尿病診療-脱"血糖屋さん"のススメ】膵β細胞からみた日本人糖尿病患者の病態と最適な治療, ;;;, May 2024, 133, 5, 1195
• 膵α細胞におけるimegliminによるグルカゴン分泌抑制と脱分化誘導の機序解明, ;;;;, May 2024, 100, 1, 317
• β細胞生物学の新展開:マウスからヒトへ　β細胞におけるグルコースシグナル伝達(New developments in beta-cell biology: from mice to humans　Glucose signaling in β-cells), 白川 純, Apr. 2024, 67, Suppl.1, S
• 糖尿病学における動物研究の今と未来　動物モデルを用いた膵β細胞研究, ;, Apr. 2024, 67, Suppl.1, S
• ヒト膵島を用いた糖尿病治療研究　本邦におけるヒト膵島を用いた膵β細胞研究, ;, Apr. 2024, 67, Suppl.1, S
• 糖尿病における膵島の変化と治療, 白川 純, Apr. 2024, 67, Suppl.1, S
• 糖尿病下の膵島で増加するアルドラーゼBの膵β細胞における機能解析, ;, Apr. 2024, 67, Suppl.1, S
• 内在性オピオイド前駆体Prodynorphinの膵β細胞増殖における役割, ;;;;, Apr. 2024, 67, Suppl.1, S
• 新規グルコース依存性インスリン分泌促進化合物の作用機序の解析, ;;;;;, Apr. 2024, 67, Suppl.1, S
• 膵α細胞においてimegliminはグルカゴン分泌の抑制および脱分化・分化転換を誘導する, ;;;;, Apr. 2024, 67, Suppl.1, S
• ヒト膵島を用いた糖尿病のトランスレーショナルリサーチ, 白川 純, Aug. 2023, 73, 3, 236
• 基礎と臨床の観点から考える経口GLP-1受容体作動薬の可能性, 白川 純, Aug. 2024, 86, 3, 146
• 新規インクレチン関連薬の可能性と期待, 白川 純, Jul. 2024, 74, 31
• 最適なインスリン治療の理論と実践, 白川 純, Oct. 2024, 24, 3, S
• 日本人2型糖尿病の特徴から考えた糖尿病治療, 白川 純, Oct. 2024, 100, 2, 581
• Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane., Wang Hao;Mizuno Kouichi;Takahashi Noriko;Kobayashi Eri;Shirakawa Jun;Terauchi Yasuo;Kasai Haruo;Okunishi Katsuhide;Izumi Tetsuro, Sep. 2020, Diabetes, 69, 12

  DOI
• Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects., Kyohara Mayu;Shirakawa Jun;Okuyama Tomoko;Togashi Yu;Inoue Ryota;Li Jinghe;Miyashita Daisuke;Terauchi Yasuo, Sep. 2020, Diabetology & metabolic syndrome, 12

  DOI
• Linagliptin Ameliorates Hepatic Steatosis via Non-Canonical Mechanisms in Mice Treated with a Dual Inhibitor of Insulin Receptor and IGF-1 Receptor., Okuyama Tomoko;Shirakawa Jun;Tajima Kazuki;Ino Yoko;Vethe Heidrun;Togashi Yu;Kyohara Mayu;Inoue Ryota;Miyashita Daisuke;Li Jinghe;Goto Nozomi;Ichikawa Taiga;Yamasaki Shingo;Ohnuma Haruka;Takayanagi Rie;Kimura Yayoi;Hirano Hisashi;Terauchi Yasuo, Oct. 2020, International journal of molecular sciences, 21, 21

  DOI
• Autosomal dominant diabetes associated with a novel ZYG11A mutation resulting in cell cycle arrest in beta-cells., Charoensuk Chutima;Thamtarana Prapaporn Jungtrakoon;Chanprasert Chutima;Tangjittipokin Watip;Shirakawa Jun;Togashi Yu;Orime Kazuki;Songprakhon Pucharee;Chaichana Chartchai;Abubakar Zuroida;Ouying Paweena;Sujjitjoon Jatuporn;Doria Alessandro;Plengvidhya Nattachet;Yenchitsomanus Pa-Thai, Dec. 2020, Molecular and cellular endocrinology, 522

  DOI
• Association of the plasma xanthine oxidoreductase activity with the metabolic parameters and vascular complications in patients with type 2 diabetes., Okuyama Tomoko;Shirakawa Jun;Nakamura Takashi;Murase Takayo;Miyashita Daisuke;Inoue Ryota;Kyohara Mayu;Togashi Yu;Terauchi Yasuo, Feb. 2021, Scientific reports, 11, 1

  DOI
• Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice., Takatani Tomozumi;Shirakawa Jun;Shibue Kimitaka;Gupta Manoj K;Kim Hyunki;Lu Shusheng;Hu Jiang;White Morris F;Kennedy Robert T;Kulkarni Rohit N, Apr. 2021, The Journal of biological chemistry, 296

  DOI
• The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes., Inoue Ryota;Nishiyama Kuniyuki;Li Jinghe;Miyashita Daisuke;Ono Masato;Terauchi Yasuo;Shirakawa Jun, Jun. 2021, Cells, 10, 7

  DOI
• The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling., Okuyama Tomoko;Kyohara Mayu;Terauchi Yasuo;Shirakawa Jun, Jun. 2021, International journal of molecular sciences, 22, 13

  DOI
• Asymptomatic meningitis diagnosed by positron emission tomography in a patient with syndrome of inappropriate antidiuretic hormone secretion: a case report., Hasebe Masanori;Shirakawa Jun;Miyashita Daisuke;Kunishita Rieko;Kyohara Mayu;Okuyama Tomoko;Togashi Yu;Terauchi Yasuo, Jul. 2021, Journal of medical case reports, 15, 1

  DOI
• Pancreatic β-cell fate in subjects with COVID-19., Shirakawa Jun, Sep. 2021, Journal of diabetes investigation, 12, 12

  DOI
• Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study., Terui Sakiko;Akamatsu Ryoichi;Arai Masanori;Inoue Ryota;Okuyama Tomoko;Kyohara Mayu;Li Jinghe;Tsuno Takahiro;Miyashita Daisuke;Togashi Yu;Terauchi Yasuo;Shirakawa Jun, Sep. 2021, Diabetes therapy : research, treatment and education of diabetes and related disorders, 12, 11

  DOI
• Validity and reliability of the Japanese version of the diabetes knowledge test among in-patients with type 2 diabetes., Minami Taichi;Shirakawa Jun;Hiiragi Hiroko;Yamada Taku;Suzuki Youichi;Shirabe Shinitiro;Maeda Hajime;Terauchi Yasuo, Oct. 2021, Journal of diabetes investigation, 13, 3

  DOI
• Translational research on human pancreatic β-cell mass expansion for the treatment of diabetes., Shirakawa Jun, Aug. 2021, Diabetology international, 12, 4

  DOI
• Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway., Li Jinghe;Inoue Ryota;Togashi Yu;Okuyama Tomoko;Satoh Aoi;Kyohara Mayu;Nishiyama Kuniyuki;Tsuno Takahiro;Miyashita Daisuke;Kin Tatsuya;Shapiro A M James;Chew Resilind Su Ern;Teo Adrian Kee Keong;Oyadomari Seiichi;Terauchi Yasuo;Shirakawa Jun, Diabetes, 71, 3

  DOI
• Insulin regulates arginine-stimulated insulin secretion in humans., Halperin Florencia;Mezza Teresa;Li Ping;Shirakawa Jun;Kulkarni Rohit N;Goldfine Allison B, Jan. 2022, Metabolism: clinical and experimental, 128

  DOI
• Recent developments in Phos-tag electrophoresis for the analysis of phosphoproteins in proteomics., Hirano Hisashi;Shirakawa Jun, Mar. 2022, Expert review of proteomics, 19, 2

  DOI
• The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion., Sobajima Mitsuaki;Miyake Masato;Hamada Yoshimasa;Tsugawa Kazue;Oyadomari Miho;Inoue Ryota;Shirakawa Jun;Arima Hiroshi;Oyadomari Seiichi, Apr. 2022, Biochemical and biophysical research communications, 611

  DOI
• Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER., Inoue Ryota;Tsuno Takahiro;Togashi Yu;Okuyama Tomoko;Sato Aoi;Nishiyama Kuniyuki;Kyohara Mayu;Li Jinghe;Fukushima Setsuko;Kin Tatsuya;Miyashita Daisuke;Shiba Yusuke;Atobe Yoshitoshi;Kiyonari Hiroshi;Bando Kana;Shapiro A M James;Funakoshi Kengo;Kulkarni Rohit N;Terauchi Yasuo;Shirakawa Jun, Jun. 2022, iScience, 25, 7

  DOI
• Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes patients: A retrospective cross-sectional study., Togashi Yu;Miyashita Daisuke;Tsuno Takahiro;Inoue Ryota;Okuyama Tomoko;Kyohara Mayu;Nishiyama Kuniyuki;Arai Masanori;Kanematsu Kenta;Kanataki Soichiro;Terauchi Yasuo;Shirakawa Jun, Jul. 2022, Journal of diabetes investigation, 13, 11

  DOI
• E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance., Shirakawa Jun;Togashi Yu;Basile Giorgio;Okuyama Tomoko;Inoue Ryota;Fernandez Megan;Kyohara Mayu;De Jesus Dario F;Goto Nozomi;Zhang Wei;Tsuno Takahiro;Kin Tatsuya;Pan Hui;Dreyfuss Jonathan M;Shapiro A M James;Yi Peng;Terauchi Yasuo;Kulkarni Rohit N, Cell reports, 41, 1

  DOI
• Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study., Kyohara Mayu;Miyashita Daisuke;Inoue Ryota;Nishiyama Kuniyuki;Tsuno Takahiro;Okuyama Tomoko;Togashi Yu;Terauchi Yasuo;Shirakawa Jun, Nov. 2022, PloS one, 17, 11

  DOI
• Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes., Miyashita Daisuke;Inoue Ryota;Tsuno Takahiro;Okuyama Tomoko;Kyohara Mayu;Nakahashi-Oda Chigusa;Nishiyama Kuniyuki;Fukushima Setsuko;Inada Yutaro;Togashi Yu;Shibuya Akira;Terauchi Yasuo;Shirakawa Jun, Nov. 2022, iScience, 25, 12

  DOI
• Signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes., Shirakawa Jun, Mar. 2023, Journal of diabetes investigation, 14, 6

  DOI
• Zinc and iron dynamics in human islet amyloid polypeptide-induced diabetes mouse model., Fukunaka Ayako;Shimura Mari;Ichinose Takayuki;Pereye Ofejiro B;Nakagawa Yuko;Tamura Yasuko;Mizutani Wakana;Inoue Ryota;Inoue Takato;Tanaka Yuto;Sato Takashi;Saitoh Tatsuya;Fukada Toshiyuki;Nishida Yuya;Miyatsuka Takeshi;Shirakawa Jun;Watada Hirotaka;Matsuyama Satoshi;Fujitani Yoshio, Mar. 2023, Scientific reports, 13, 1

  DOI
• A Disproportionality Analysis of the Adverse Effect Profiles of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Using the Japanese Adverse Drug Event Report Database., Arai Masanori;Tsuno Takahiro;Konishi Hiromi;Nishiyama Kuniyuki;Terauchi Yasuo;Inoue Ryota;Shirakawa Jun, May 2023, Thyroid : official journal of the American Thyroid Association, 33, 7

  DOI
• Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice., Nishiyama Kuniyuki;Ono Masato;Tsuno Takahiro;Inoue Ryota;Fukunaka Ayako;Okuyama Tomoko;Kyohara Mayu;Togashi Yu;Fukushima Setsuko;Atsumi Takuto;Sato Aoi;Tsurumoto Asuka;Sakai Chisato;Fujitani Yoshio;Terauchi Yasuo;Ito Shuichi;Shirakawa Jun, Endocrinology, 164, 8

  DOI
• Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion., Moon Sohyun;Alsarkhi Lamyaa;Lin Tai-Tu;Inoue Ryota;Tahiri Azeddine;Colson Cecilia;Cai Weikang;Shirakawa Jun;Qian Wei-Jun;Zhao Jerry Yingtao;El Ouaamari Abdelfattah, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37, 10

  DOI
• Encapsulated human islets in alginate fiber maintain long-term functionality., Nishida Junko;Tsuno Takahiro;G Yabe Shigeharu;Kin Tatsuya;Fukuda Satsuki;Takeda Fujie;Shirakawa Jun;Okochi Hitoshi, Dec. 2023, Endocrine journal

  DOI
• Corrigendum to "The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion" [Biochem. Biophys. Res. Commun. 611 (2022) 165-171]., Sobajima Mitsuaki;Miyake Masato;Hamada Yoshimasa;Tsugawa Kazue;Oyadomari Miho;Inoue Ryota;Shirakawa Jun;Arima Hiroshi;Oyadomari Seiichi, Dec. 2023, Biochemical and biophysical research communications, 692

  DOI
• Immediate Impact of Switching from Dipeptidyl Peptidase 4 (DPP4) Inhibitors to Low-Dose (0.3 mg) Liraglutide on Glucose Profiles: A Retrospective Observational Study., Terui Sakiko;Igari Mari;Tsuno Takahiro;Okuyama Tomoko;Inoue Ryota;Kyohara Mayu;Terauchi Yasuo;Shirakawa Jun, Mar. 2024, Diabetes therapy : research, treatment and education of diabetes and related disorders

  DOI
• プロトン感知性受容体TDAG8はマウス脳虚血モデルの脳損傷において抑制的に働く, ;;;, Nov. 2021, 94回, [3T13a
• 膵臓内分泌細胞の最前線　液性因子を介した膵β細胞増殖促進機構の新機軸, 白川 純, Apr. 2022, 98, 1, 182
• Imegliminは小胞体ストレスによるアポトーシスからβ細胞を保護する(Imeglimin protects β-cells against endoplasmic reticulum stress-induced apoptosis), ;;, Apr. 2022, 98, 1, 286
• 新時代における分子糖尿病学　糖尿病の合併症予防へ向けた分子機序からのアプローチ, 白川 純, Apr. 2022, 65, Suppl.1, S
• 分子糖尿病学研究へのいざない　UCP2およびアルドラーゼBによる膵β細胞障害機構の解明, ;;, Apr. 2022, 65, Suppl.1, S
• 膵β細胞障害過程におけるUCP2によるAldB誘導機構の解析, ;;;;;, Apr. 2022, 65, Suppl.1, S
• Imegliminは小胞体ホメオスタシス経路調節によりβ細胞生存を促進する(Imeglimin promotes β-cell survival by modulating the endoplasmic reticulum homeostasis pathway), ;;, Apr. 2022, 65, Suppl.1, S
• 膵島においてグルコースにより誘導されるProdynorphinの糖代謝への影響, ;;;;;;, Apr. 2022, 65, Suppl.1, S
• 膵島研究(再生,移植,インスリン分泌)の現状と展望　急性インスリン抵抗性に対する膵β細胞量の代償性増大機構, 白川 純, Apr. 2023, 66, Suppl.1, S
• 経口血糖降下薬の新展開　イメグリミン, 白川 純, Apr. 2023, 66, Suppl.1, S
• インスリン抵抗性に応答する代償性β細胞複製のメカニズム(Mechanisms underlying compensatory β cell replication in response to insulin resistance), 白川 純, Apr. 2023, 66, Suppl.1, S
• 2型糖尿病ヒト膵島で発現上昇するアルドラーゼBの膵β細胞における作用の解析, ;;, Apr. 2023, 66, Suppl.1, S
• 肥満糖尿病db/dbマウスにおけるimegliminとmetforminの併用による膵β細胞保護効果の検討, ;;;;;;;, Apr. 2023, 66, Suppl.1, S
• 膵島のMulti electrode array(MEA:微小電極アレイ)を用いた生理機能の解析, ;;;;, Apr. 2023, 66, Suppl.1, S
• ヒト型糖尿病モデルマウスの膵島における金属動態変化, ;;;;;;;, Apr. 2023, 66, Suppl.1, S
• Imegliminの膵α細胞機能や遺伝子発現への影響の解析, ;;;;;, Apr. 2023, 66, Suppl.1, S
• ヒト膵島を用いた糖尿病のトランスレーショナルリサーチ, 白川 純, Aug. 2023, 73, 3, 236
• ヒト膵島を用いた糖尿病治療研究の基盤形成, 白川 純, Dec. 2023, 37, 1
• 【患者の将来を見据えた実践的糖尿病診療-脱"血糖屋さん"のススメ】膵β細胞からみた日本人糖尿病患者の病態と最適な治療, ;;;, May 2024, 133, 5, 1195
• 膵α細胞におけるimegliminによるグルカゴン分泌抑制と脱分化誘導の機序解明, ;;;;, May 2024, 100, 1, 317
• β細胞生物学の新展開:マウスからヒトへ　β細胞におけるグルコースシグナル伝達(New developments in beta-cell biology: from mice to humans　Glucose signaling in β-cells), 白川 純, Apr. 2024, 67, Suppl.1, S
• 糖尿病学における動物研究の今と未来　動物モデルを用いた膵β細胞研究, ;, Apr. 2024, 67, Suppl.1, S
• ヒト膵島を用いた糖尿病治療研究　本邦におけるヒト膵島を用いた膵β細胞研究, ;, Apr. 2024, 67, Suppl.1, S
• 糖尿病における膵島の変化と治療, 白川 純, Apr. 2024, 67, Suppl.1, S
• 糖尿病下の膵島で増加するアルドラーゼBの膵β細胞における機能解析, ;, Apr. 2024, 67, Suppl.1, S
• 内在性オピオイド前駆体Prodynorphinの膵β細胞増殖における役割, ;;;;, Apr. 2024, 67, Suppl.1, S
• 新規グルコース依存性インスリン分泌促進化合物の作用機序の解析, ;;;;;, Apr. 2024, 67, Suppl.1, S
• 膵α細胞においてimegliminはグルカゴン分泌の抑制および脱分化・分化転換を誘導する, ;;;;, Apr. 2024, 67, Suppl.1, S
• 新規インクレチン関連薬の可能性と期待, 白川 純, Jul. 2024, 74, 31
• 基礎と臨床の観点から考える経口GLP-1受容体作動薬の可能性, 白川 純, Aug. 2024, 86, 3, 146
• 日本人2型糖尿病の特徴から考えた糖尿病治療, 白川 純, Oct. 2024, 100, 2, 581
• 最適なインスリン治療の理論と実践, 白川 純, Oct. 2024, 24, 3, S
• 最適なインスリン治療の理論と実践, 白川 純, Feb. 2025, 25, 1, S

MISC

• Characterization of Insulin-Like Growth Factor-2 Receptor (IGF-2R) in Pancreatic beta-Cells, Jun Shirakawa; Erin R. Okawa; Rohit N. Kulkarni, Jun. 2017, DIABETES, 66, A12, A12, Summary international conference
• Identification of Soluble EGFR as a Serum Biomarker of Insulin Resistance by a Quantitative Proteomic Analysis Using Mice with Diabetes, Mayu Kyohara; Jun Shirakawa; Ayuko Kimura; Hisashi Hirano; Yasuo Terauchi, Jun. 2017, DIABETES, 66, A542, A542, Summary international conference
• Differential Regulation of Metabolic and Protein Synthesis Pathways in Mouse Embryonic Fibroblasts and Induced Pluripotent Stem Cells from Leptin Receptor Deficient Mice, Manoj K. Gupta; Heidrun Vethe; Vilas Wagh; Jun Shirakawa; Samir Softic; Harald Barsnes; Marc Vaudel; Tomozumi Takatani; Rachel Martinez; Jiang Hu; Helge Raeder; Rohit N. Kulkarni, Jun. 2016, DIABETES, 65, A504, A505, Summary international conference
• Histone H3 Variant Centromere Protein A (CENP-A) Is Critical for beta-Cell Proliferation, Jun Shirakawa; Megan Fernandez; Rohit N. Kulkarni, Jun. 2016, DIABETES, 65, A17, A17, Summary international conference
• Inflammatory Cytokines Activate NGN3 and Induce Pancreatic Ductal-to-Endocrine Cell Differentiation, Ivan A. Valdez; Ercument Dirice; Manoj K. Gupta; Jun Shirakawa; Adrian K. K. Teo; Rohit N. Kulkarni, Jun. 2016, DIABETES, 65, A531, A531, Summary international conference
• Fibulin5 Deficiency Improved Insulin Resistance and Hepatic Steatosis Induced by High-Fat Feeding, Tomoko Okuyama; Jun Shirakawa; Hiromi Yanagisawa; Yasuo Terauchi, Jun. 2015, DIABETES, 64, A492, A493, Summary international conference
• Identification of Novel Genes Contributing to Autosomal Dominant Diabetes by Whole-Exome Sequencing, Prapaporn Jungtrakoon; Patinut Buranasupkajorn; Timothy Hastings; Jun Shirakawa; Marcus Pezzolesi; Christine Mendonca; Rohit N. Kulkarni; Alessandro Doria, Jun. 2015, DIABETES, 64, A460, A461, Summary international conference
• Quantitative Comparative Proteomic Analysis of Serum Proteins Associated with the Progression of Diabetes in db/db Mouse, Mayu Kyohara; Jun Shirakawa; Ayuko Kimura; Hisashi Hirano; Yasuo Terauchi, Jun. 2015, DIABETES, 64, A545, A545, Summary international conference
• IRS-1 Plays Distinct Roles in ER Stress-mediated beta-Cell Death by Modulating the IRE1 Alpha-XBP-1 Arm and Protein Translation, Tomozumi Takatani; Jun Shirakawa; Rohit N. Kulkarni, Jun. 2015, DIABETES, 64, A34, A35, Summary international conference
• Insulin Regulates G2/M-phase Cell Cycle Transition by Modulating the Expression and Deposition of CENP-A in Pancreatic beta Cells, Jun Shirakawa; Tomozumi Takatani; Abdelfattah El Ouaamari; Rohit N. Kulkarni, Jun. 2015, DIABETES, 64, A65, A65, Summary international conference
• The role of S100A8 and S100A9 in inflammatory interaction between pancreatic islets and macrophages, H. Inoue; J. Shirakawa; K. Orime; Y. Togashi; K. Tajima; Y. Terauchi, Sep. 2014, DIABETOLOGIA, 57, S304, S304, Summary international conference
• Isolation of target genes of liraglutide, a GLP-1 receptor agonist, in pancreatic islets by using nano-LC-MS/MS system, E. Yoshida; J. Shirakawa; A. Kimura; H. Hirano; Y. Terauchi, Sep. 2014, DIABETOLOGIA, 57, S171, S171, Summary international conference
• Coordinated effects of macrophages and free fatty acids on the inflammatory gene expression in pancreatic islets, H. Inoue; J. Shirakawa; K. Orime; Y. Togashi; Y. Terauchi, Sep. 2013, DIABETOLOGIA, 56, S303, S303, Summary international conference
• Partial Pancreatectomy Facilitated beta-Cell Proliferation in Glucokinase Haploinsufficient Mice and IRS-2 Deficient Mice, Yu Togashi; Jun Shirakawa; Kazuki Orime; Hideaki Inoue; Akinobu Nakamura; Yasuo Terauchi, Jul. 2013, DIABETES, 62, A564, A564, Summary international conference
• Characterization of Target Genes of Glucokinase Activator (GKA) in Pancreatic Islets, Jun Shirakawa; Kazuki Orime; Yu Togashi; Hideaki Inoue; Yasuo Terauchi, Jul. 2013, DIABETES, 62, A94, A95, Summary international conference
• Metformin prevents high-fat diet-induced liver tumorigenesis in C57BL/6J mice, K. Tajima; A. Nakamura; J. Shirakawa; K. Orime; Y. Togashi; Y. Nagashima; Y. Terauchi, Oct. 2012, DIABETOLOGIA, 55, S288, S289, Summary international conference
• Regulation of Expression of Incretin Receptors In Islet by Dephosphorylation of AMPK, Kazuki Tajima; Jun Shirakawa; Kazuki Orime; Yu Togashi; Yasuo Terauchi, Jun. 2012, DIABETES, 61, A543, A543, Summary international conference
• Glucokinase Activator Ameliorates beta Cell ER Stress and Apoptosis by both IRS-2-Dependent and -Independent Pathways, Jun Shirakawa; Yasuo Terauchi, Jun. 2012, DIABETES, 61, A66, A66, Summary international conference
• Trefoil Factor 2 Promotes Cell Proliferation in Pancreatic B Cells Through a Cxcr4-Mediated Erk1/2 Pathway, Kazuki Orime; Jun Shirakawa; Akinobu Nakamura; Kazuki Tajima; Yu Togashi; Yasuo Terauchi, Jun. 2012, DIABETES, 61, A530, A530, Summary international conference
• Protective effects of DPP-4 inhibitor against increased beta cell apoptosis with multiorgan glucolipotoxicity by a combination of dietary sugar and fatty acid, J. Shirakawa; E. Takeda; Y. Terauchi, Sep. 2010, DIABETOLOGIA, 53, Summary international conference
• Increased beta Cell Apoptosis with Multiorgan Glucolipotoxicity by a Combination of Dietary Sugar and Fatty Acid and Protective Effects of DPP-4 Inhibitor Des-Fluoro-Sitagliptin Against Them, Jun Shirakawa; Eiji Takeda; Yasuo Terauchi, Jun. 2010, DIABETES, 59, A440, A440, Summary international conference
• A Crucial Role of IRS-2 in the Proliferation of Beta Cells Stimulated by Small Molecule Glucokinase Activator, Akinobu Nakamura; Yu Togashi; Koichiro Sato; Jun Shirakawa; Yasuo Terauchi, Jun. 2010, DIABETES, 59, A123, A123, Summary international conference
• Long-Term High-Fat Diet Loading Induced Steatohepatitis and Hepatocellular Carcinoma in a Mouse Model, Akinobu Nakamura; Koichiro Sato; Jun Shirakawa; Yoji Nagashima; Yasuo Terauchi, Jun. 2010, DIABETES, 59, A415, A415, Summary international conference
• Protective effects of DPP-4 inhibitor des-fluoro-sitagliptin against multiorgan glucolipotoxicity induced by dietary sugar and fatty acids, Jun Shirakawa; Eiji Takeda; Yasuo Terauchi, Mar. 2010, ENDOCRINE JOURNAL, 57, S361, S361, Summary international conference
• Role of glucokinase on pancreatic beta-cell mass and impact of glucokinase activator on the regulation of beta-cell mass, Yasuo Terauchi; Akinobu Nakamura; Jun Shirakawa, Mar. 2010, ENDOCRINE JOURNAL, 57, S215, S215, Summary international conference
• beta Cell Proliferation and Expansion of beta Cell Mass Were Independent of Glucokinase in 60% Partial Pancreatectomized Mice, Yu Togashi; Jun Shirakawa; Akinobu Nakamura; Yasuo Terauchi, Jul. 2011, DIABETES, 60, A529, A529, Summary international conference
• ヒト膵島研究の世界的動向 (糖尿病) -- (基礎分野での進歩), 白川 純; 寺内 康夫, 2016, 13, 20
• GLUCOSE SIGNAL-MEDIATED REGULATION OF ENDOPLASMIC RETICULUM STRESS IN PANCREATIC β CELLS, 白川 純, Oct. 2014, 65, 4, 523, 528
• The effects of glucokinase activation on β cell function, proliferation, and survival, 白川 純; 寺内 康夫, Apr. 2014, 38, 4, 339, 345
• 注目の新薬 シタグリプチンリン酸塩水和物(ジャヌビア錠,グラクティブ錠), 白川 純; 寺内 康夫, Dec. 2010, 98, 12, 2043, 2047
• DPP-4 inhibitors, 白川 純; 寺内 康夫, Jan. 2010, 58, 1, 73, 79
• Defects in regulation beta cell mass in response to insulin resistance, 白川 純; 中村 昭伸; 寺内 康夫, Sep. 2008, The Cell, 40, 10, 421, 425
• 縁取り空胞型遠位型ミオパチー(DMRV)を合併したバセドウ病の一例, 白川 純; 岸田 日帯; 菊地 香織; 折目 和基; 佐藤 光一郎; 富樫 優; 宮崎 岳之; 伊藤 譲; 黒岩 義之; 寺内 康夫, Dec. 2010, 86, 3, 726, 726

Awards

• JDS Lilly award, May 2021
• May 2020
• Jun. 2019
• May 2019
• Sep. 2018
• Feb. 2018
• American Diabetes Association's (ADA) 77nd Scientific Sessions Young Investigator Travel Grant Award, American Diabetes Association's (ADA), Jun. 2017
• May 2014
• 72nd Scientific Sessions Young Investigator Travel Grant Award, Jun Shirakawa, American Diabetes Association's (ADA), Jun. 2012
• May 2012
• Apr. 2012
• Mar. 2012
• Dec. 2011
• Nov. 2011
• the grand prize, Jun Shirakawa, JASSO's Student of the Year, Dec. 2005
• Mar. 2005
• Asian Association for Study of Diabetes (AASD) The Masato Kasuga Award for Outstanding Scientific Achievement, Jun Shirakawa, Oct. 2022

Research Projects

• Regulation of beta cell fate during dedifferentiation, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2020, 31 Mar. 2023, 20K08866

  対象リソースIRI
• Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Yokohama City University, 01 Apr. 2020, 31 Mar. 2023, 20H03733

  対象リソースIRI
• A novel sarcopenia model by insulin / IGF-1 receptor inhibition, TOGASHI Yu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Yokohama City University, 01 Apr. 2018, 31 Mar. 2021, We analyzed the mechanism of sarcopenia in patients with type 2 diabetes using an animal model treated with OSI-906, the insulin receptor (IR)/ IGF-1 receptor (IFG1R) inhibitor. After 14 days of administration of OSI-906, the OSI-906 group showed hyperglycemia, body weight loss, and decreased weight of quadriceps and gastrocnemius muscles. Tissue analysis showed a significant increase in the number and proportion of oxidative fibers in the tibialis anterior muscle after OSI-906 administration, indicating that inhibition of IR and IGF1R induces plastic changes in fully differentiated skeletal muscle. Genetic analysis indicated OSI-906 promotes glucose uptake in skeletal muscle, suppress cell cycle control, promotes proteolysis, and enhances autophagy., 18K08484

  対象リソースIRI
• Heterogeneity of pancreatic islets, Shirakawa Jun, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Yokohama City University, 01 Apr. 2018, 31 Mar. 2020, Recent studies showed subpopulation of pancreatic β cells in the context of functional and phenotypic heterogeneity. Distinct β cell subpopulations potentially have unique functional identity. We topologically divided pancreas into a head (right side, nestled in the curve of the duodenum), body, and tail (left side in close proximity with the spleen) region in mice. Then, we compared head islets with tail islets histologically and functionally. Tail islets contained significantly higher proportion of α-cells. Glucose-stimulated insulin secretion was significantly greater in tail islets than in head islets, while β cells in head islets showed higher response to GLP-1. The results of gene expression microarray analysis and proteomics analysis indicated that some functional genes including pancreatic progenitor markers were differentially expressed between head and tail islets. Thus, pancreatic islets harbor functional diversity in terms of various aspects of β cell function., 18K16240

  対象リソースIRI
• Fate determination of pancreatic beta cells by glucokinase activation, Terauchi Yasuo; Tajima Kazuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Yokohama City University, 01 Apr. 2016, 31 Mar. 2019, We had investigated the impacts of glucokinase-mediated glucose signal in the regulation of beta cell function and proliferation. We now systematically investigated changes in the expression of genes involved in beta cell function and proliferation in mouse islets stimulated with glucokinase activator (GKA). GKA-stimulated IRS2 production affected beta cell proliferation but not beta cell function. Specifically, we focused the roles of fibulin 5, EGFR and S100A8 in beta cells. Of note, both glucotoxicity and lipotoxicity triggered S100A8 secretion from pancreatic islets, which in turn promoted macrophage infiltration of the islets. A positive feedback loop between islet-derived S100A8 and macrophages drives beta-cell apoptosis and pancreatic islet inflammation., 16H05329

  対象リソースIRI
• Glucokinase Activation Ameliorates ER Stress-Induced Apoptosis in Pancreatic Beta-Cells, SHIRAKAWA JUN, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Yokohama City University, 01 Apr. 2013, 31 Mar. 2015, Glucokinase upregulates insulin receptor substrate 2 (IRS-2) expression in beta-cells, but the role of glucokinase and IRS-2 in ER stress has been unclear. In this study, we investigated the impact of glucokinase activation by glucokinase activator (GKA) on ER stress in beta-cells. GKA administration improved beta-cell apoptosis in Akita mice, a model of ER stress-mediated diabetes. IRS-2-deficient islets were vulnerable, but bIRS-2-Tg islets were resistant to ER stress-induced apoptosis. Meanwhile, GKA regulated the expressions of C/EBP homologous protein (CHOP) and other ER stress-related genes in an IRS-2-independent fashion in islets. GKA suppressed the expressions of CHOP and Bcl2-associated X protein (Bax) and protected against beta-cell apoptosis under ER stress in an ERK1/2-dependent, IRS-2-independent manner. Taken together, GKA ameliorated ER stress-mediated apoptosis by harmonizing IRS-2 upregulation and the IRS-2-independent control of apoptosis in beta-cells., 25860754

  対象リソースIRI
• Establishing a base for tailor-made therapy on diabetes from the view point of the pancreatic beta cell mass, TERAUCHI Yasuo; SHIRAKAWA Jun, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Yokohama City University, 01 Apr. 2012, 31 Mar. 2015, We investigated changes in the expression of genes involved in beta cell function and proliferation in mouse islets stimulated with glucokinase activator (GKA) in order to elucidate the mechanisms by which GKA stimulates beta cell function and proliferation. GKA-stimulated IRS2 production affected beta cell proliferation but not beta cell function. We investigated the impact of glucokinase activation by GKA on ER stress in β cells. GKA administration improved β-cell apoptosis in Akita mice, a model of ER stress-mediated diabetes. GKA ameliorated ER stress-mediated apoptosis by harmonizing IRS-2 upregulation and the IRS-2-independent control of apoptosis in β cells. IRS-2 knockout mice exhibited an enhancement in β-cell proliferation after a pancreatectomy equal to that observed in wild-type mice. A pancreatectomy stimulated β-cell proliferation via a signaling pathway different from that involved in high-fat diet-induced β-cell expansion., 24390235

  対象リソースIRI