Researcher Profile and Settings

Researcher

• Name

  SASAKI Nobuo

Profile and Settings

• Name

  Sasaki, Nobuo

Alternate Names

• Sasaki Nobuo

Website

• URI

  https://sasaki-lab.imcr.gunma-u.ac.jp/

Affiliation

• Gunma University, Institute for Molecular and Cellular Regulation

Education

• Apr. 2003, Mar. 2006, Tokyo University of Science, Graduate School of Industrial Science and Technology
• Apr. 2001, Mar. 2003, Tokyo University of Science, Graduate School of Industrial Science and Technology
• Apr. 1997, Mar. 2001, Tokyo University of Science, Faculty of Industrial Science and Technology, Biological Science and Technology

Degree

• Ph.D.

Research Experience

• Apr. 2021, 9999, Gunma University, Institute for Molecular and Cellular Regulation, Professor
• Jan. 2016, Mar. 2021, Keio University, School of Medicine
• Jan. 2011, Dec. 2015
• Apr. 2006, Dec. 2010, National Institute of Genetics

Research Activities

Research Areas

• organ development, orgnaoid
• Life sciences, Gastroenterology

Research Interests

• organoid
• developmental biology
• Gut microbiology
• adult tissue stem cell biology

Published Papers

• Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression, Ishihara R, Oda T, Murakami Y, Matsumura I, Watanabe S, Asao Y, Masuda Y, Gotoh N, Kasamatsu T, Takei H, Kobayashi N, Sasaki N, Saitoh T, Murakami H, Handa H., Jan. 2023, Int J Mol Sci, 24, 3, 2216, Scientific journal

  DOI
• DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nulear foci and phase separation, Oda T, Gotoh N, Kasamatsu T, Handa H, Saitoh T, Sasaki N, Jan. 2023, Cell Proliferation, e13398

  DOI
• Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium., Nobuo Sasaki; Kentaro Miyamoto; Kendle M Maslowski; Hiroshi Ohno; Takanori Kanai; Toshiro Sato, Jul. 2020, Gastroenterology, 159, 1, 388, 390, Scientific journal

  DOI
• Somatic inflammatory gene mutations in human ulcerative colitis epithelium., Kosaku Nanki; Masayuki Fujii; Mariko Shimokawa; Mami Matano; Shingo Nishikori; Shoichi Date; Ai Takano; Kohta Toshimitsu; Yuki Ohta; Sirirat Takahashi; Shinya Sugimoto; Kazuhiro Ishimaru; Kenta Kawasaki; Yoko Nagai; Ryota Ishii; Kosuke Yoshida; Nobuo Sasaki; Toshifumi Hibi; Soichiro Ishihara; Takanori Kanai; Toshiro Sato, Jan. 2020, Nature, 577, 7789, 254, 259, Scientific journal

  DOI
• Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion., Johan H van Es; Kay Wiebrands; Carmen Lopez-Iglesias; Marc van de Wetering; Laura Zeinstra; Maaike van den Born; Jeroen Korving; Nobuo Sasaki; Peter J Peters; Alexander van Oudenaarden; Hans Clevers, 16 Dec. 2019, Proceedings of the National Academy of Sciences of the United States of America, Scientific journal

  DOI
• Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells., Han S, Fink J, Jorg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Ph, 05 Sep. 2019, Cell stem cell, 25, 3, 342, 356, Scientific journal

  DOI
• Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids., Ana C F Bolhaqueiro; Bas Ponsioen; Bjorn Bakker; Sjoerd J Klaasen; Emre Kucukkose; Richard H van Jaarsveld; Judith V; Ingrid Verlaan-Klink; Nizar Hami; Diana C J Spierings; Nobuo Sasaki; Devanjali Dutta; Sylvia F Boj; Robert G J Vries; Peter M Lansdorp; Marc van de Wetering; Alexander van Oudenaarden; Hans Clevers; Onno Kranenburg; Floris Foijer; Hugo J G Snippert; Geert J P L Kops, May 2019, Nature genetics, 51, 5, 824, 834, Scientific journal

  DOI
• Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis., Nobuhiro Nakamoto; Nobuo Sasaki; Ryo Aoki; Kentaro Miyamoto; Wataru Suda; Toshiaki Teratani; Takahiro Suzuki; Yuzo Koda; Po-Sung Chu; Nobuhito Taniki; Akihiro Yamaguchi; Mitsuhiro Kanamori; Nobuhiko Kamada; Masahira Hattori; Hiroshi Ashida; Michiie Sakamoto; Koji Atarashi; Seiko Narushima; Akihiko Yoshimura; Kenya Honda; Toshiro Sato; Takanori Kanai, Mar. 2019, Nature microbiology, 4, 3, 492, 503, Scientific journal

  DOI
• Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites., Akiko Mito; Yukiko Nakano; Takako Saitoh; Sabine S S Gouraud; Yoshiki Yamaguchi; Toshiro Sato; Nobuo Sasaki; Kyoko Kojima-Aikawa, 01 Dec. 2018, Glycobiology, 28, 1, 21, 31, Scientific journal

  DOI
• Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology., Nobuo Sasaki; Hans Clevers, Oct. 2018, Current opinion in genetics & development, 52, 117, 122, Scientific journal

  DOI
• Intra-tumour diversification in colorectal cancer at the single-cell level., Sophie F Roerink; Nobuo Sasaki; Henry Lee-Six; Matthew D Young; Ludmil B Alexandrov; Sam Behjati; Thomas J Mitchell; Sebastian Grossmann; Howard Lightfoot; David A Egan; Apollo Pronk; Niels Smakman; Joost van Gorp; Elizabeth Anderson; Stephen J Gamble; Chris Alder; Marc van de Wetering; Peter J Campbell; Michael R Stratton; Hans Clevers, Apr. 2018, Nature, 556, 7702, 457, 462, Scientific journal

  DOI
• Automated brightfield morphometry of 3D organoid populations by OrganoSeg., Michael A Borten; Sameer S Bajikar; Nobuo Sasaki; Hans Clevers; Kevin A Janes, 28 Mar. 2018, Scientific reports, 8, 1, 5319, 5319, Scientific journal

  DOI
• Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer., Jarno Drost; Ruben van Boxtel; Francis Blokzijl; Tomohiro Mizutani; Nobuo Sasaki; Valentina Sasselli; Joep de Ligt; Sam Behjati; Judith E Grolleman; Tom van Wezel; Serena Nik-Zainal; Roland P Kuiper; Edwin Cuppen; Hans Clevers, 13 Oct. 2017, Science (New York, N.Y.), 358, 6360, 234, 238, Scientific journal

  DOI
• Tissue-specific mutation accumulation in human adult stem cells during life., Francis Blokzijl; Joep de Ligt; Myrthe Jager; Valentina Sasselli; Sophie Roerink; Nobuo Sasaki; Meritxell Huch; Sander Boymans; Ewart Kuijk; Pjotr Prins; Isaac J Nijman; Inigo Martincorena; Michal Mokry; Caroline L Wiegerinck; Sabine Middendorp; Toshiro Sato; Gerald Schwank; Edward E S Nieuwenhuis; Monique M A Verstegen; Luc J W van der Laan; Jeroen de Jonge; Jan N M IJzermans; Robert G Vries; Marc van de Wetering; Michael R Stratton; Hans Clevers; Edwin Cuppen; Ruben van Boxtel, 13 Oct. 2016, Nature, 538, 7624, 260, 264, Scientific journal

  DOI
• Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon., Nobuo Sasaki; Norman Sachs; Kay Wiebrands; Saskia I J Ellenbroek; Arianna Fumagalli; Anna Lyubimova; Harry Begthel; Maaike van den Born; Johan H van Es; Wouter R Karthaus; Vivian S W Li; Carmen Lpez-Iglesias; Peter J Peters; Jacco van Rheenen; Alexander van Oudenaarden; Hans Clevers, 13 Sep. 2016, Proceedings of the National Academy of Sciences of the United States of America, 113, 37, E5399-407, Scientific journal

  DOI
• Single-cell messenger RNA sequencing reveals rare intestinal cell types., Dominic Grun; Anna Lyubimova; Lennart Kester; Kay Wiebrands; Onur Basak; Nobuo Sasaki; Hans Clevers; Alexander van Oudenaarden, 10 Sep. 2015, Nature, 525, 7568, 251, 5, Scientific journal

  DOI
• Long-term culture of genome-stable bipotent stem cells from adult human liver., Meritxell Huch; Helmuth Gehart; Ruben van Boxtel; Karien Hamer; Francis Blokzijl; Monique M A Verstegen; Ewa Ellis; Martien van Wenum; Sabine A Fuchs; Joep de Ligt; Marc van de Wetering; Nobuo Sasaki; Susanne J Boers; Hans Kemperman; Jeroen de Jonge; Jan N M Ijzermans; Edward E S Nieuwenhuis; Ruurdtje Hoekstra; Stephen Strom; Robert R G Vries; Luc J W van der Laan; Edwin Cuppen; Hans Clevers, 15 Jan. 2015, Cell, 160, 1-2, 299, 312, Scientific journal

  DOI
• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients., Gerald Schwank; Bon-Kyoung Koo; Valentina Sasselli; Johanna F Dekkers; Inha Heo; Turan Demircan; Nobuo Sasaki; Sander Boymans; Edwin Cuppen; Cornelis K van der Ent; Edward E S Nieuwenhuis; Jeffrey M Beekman; Hans Clevers, 05 Dec. 2013, Cell stem cell, 13, 6, 653, 8, Scientific journal

  DOI
• In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration., Meritxell Huch; Craig Dorrell; Sylvia F Boj; Johan H van Es; Vivian S W Li; Marc van de Wetering; Toshiro Sato; Karien Hamer; Nobuo Sasaki; Milton J Finegold; Annelise Haft; Robert G Vries; Markus Grompe; Hans Clevers, 14 Feb. 2013, Nature, 494, 7436, 247, 50, Scientific journal

  DOI
• Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster., Naoki Aoyama; Tomoko Yamakawa; Takeshi Sasamura; Yuka Yoshida; Maki Ohori; Hiroyuki Okubo; Eriko Iida; Nobuo Sasaki; Ryu Ueda; Kenji Matsuno, 2013, Genes & genetic systems, 88, 1, 45, 57, Scientific journal
• Generation of BAC transgenic epithelial organoids., Gerald Schwank; Amanda Andersson-Rolf; Bon-Kyoung Koo; Nobuo Sasaki; Hans Clevers, 2013, PloS one, 8, 10, e76871, Scientific journal

  DOI
• Dll1+ secretory progenitor cells revert to stem cells upon crypt damage., Johan H van Es; Toshiro Sato; Marc van de Wetering; Anna Lyubimova; Annie Ng Yee Nee; Alex Gregorieff; Nobuo Sasaki; Laura Zeinstra; Maaike van den Born; Jeroen Korving; Anton C M Martens; Nick Barker; Alexander van Oudenaarden; Hans Clevers, Oct. 2012, Nature cell biology, 14, 10, 1099, 1104, Scientific journal

  DOI
• Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo., Toshinao Oyama; Kenichi Harigaya; Nobuo Sasaki; Yoshiaki Okamura; Hiroki Kokubo; Yumiko Saga; Katsuto Hozumi; Akiko Suganami; Yutaka Tamura; Takahiro Nagase; Hisashi Koga; Motoi Nishimura; Reiko Sakamoto; Mitsuharu Sato; Nobuaki Yoshida; Motoo Kitagawa, Dec. 2011, Development (Cambridge, England), 138, 23, 5235, 46, Scientific journal

  DOI
• The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis., Nobuo Sasaki; Makoto Kiso; Motoo Kitagawa; Yumiko Saga, Jan. 2011, Development (Cambridge, England), 138, 1, 55, 64, Scientific journal

  DOI
• Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome., Alberto S Cornier; Karen Staehling-Hampton; Kym M Delventhal; Yumiko Saga; Jean-Francois Caubet; Nobuo Sasaki; Sian Ellard; Elizabeth Young; Norman Ramirez; Simon E Carlo; Jose Torres; John B Emans; Peter D Turnpenny; Olivier Pourquié, Jun. 2008, American journal of human genetics, 82, 6, 1334, 41, Scientific journal

  DOI
• The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila., Takeshi Sasamura; Hiroyuki O Ishikawa; Nobuo Sasaki; Syunsuke Higashi; Maiko Kanai; Shiho Nakao; Tomonori Ayukawa; Toshiro Aigaki; Katsuhisa Noda; Eiji Miyoshi; Naoyuki Taniguchi; Kenji Matsuno, Apr. 2007, Development (Cambridge, England), 134, 7, 1347, 56, Scientific journal
• The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite., Mitsuru Morimoto; Nobuo Sasaki; Masayuki Oginuma; Makoto Kiso; Katsuhide Igarashi; Ken-ichi Aizaki; Jun Kanno; Yumiko Saga, Apr. 2007, Development (Cambridge, England), 134, 8, 1561, 9, Scientific journal
• Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells., Nobuo Sasaki; Takeshi Sasamura; Hiroyuki O Ishikawa; Maiko Kanai; Ryu Ueda; Kaoru Saigo; Kenji Matsuno, Jan. 2007, Genes to cells : devoted to molecular & cellular mechanisms, 12, 1, 89, 103, Scientific journal
• Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis., Mitsuru Morimoto; Makoto Kiso; Nobuo Sasaki; Yumiko Saga, 15 Dec. 2006, Developmental biology, 300, 2, 687, 98, Scientific journal
• neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions., Takeshi Sasamura; Nobuo Sasaki; Fumiyasu Miyashita; Shiho Nakao; Hiroyuki O Ishikawa; Mikiko Ito; Motoo Kitagawa; Kenichi Harigaya; Eric Spana; David Bilder; Norbert Perrimon; Kenji Matsuno, Oct. 2003, Development (Cambridge, England), 130, 20, 4785, 95, Scientific journal
• Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios(+) Tregs in the gut, Yoshimatsu, Yusuke;Sujino, Tomohisa;Miyamoto, Kentaro;Harada, Yosuke;Tanemoto, Shun;Ono, Keiko;Umeda, Satoko;Yoshida, Kosuke;Teratani, Toshiaki;Suzuki, Takahiro;Mikami, Yohei;Nakamoto, Nobuhiro;Sasaki, Nobuo;Takabayashi, Kaoru;Hosoe, Naoki;Ogata, Haruhiko;Sawada, Kazuaki;Imamura, Takeshi;Yoshimura, Akihiko;Kanai, Takanori, 2022, CELL REPORTS, 39, 6

  DOI
• Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice, Yamazaki, Kyoko;Miyauchi, Eiji;Kato, Tamotsu;Sato, Keisuke;Suda, Wataru;Tsuzuno, Takahiro;Yamada-Hara, Miki;Sasaki, Nobuo;Ohno, Hiroshi;Yamazaki, Kazuhisa, 2022, JOURNAL OF ORAL MICROBIOLOGY, 14, 1

  DOI
• DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation, Oda, Tsukasa;Gotoh, Nanami;Kasamatsu, Tetsuhiro;Handa, Hiroshi;Saitoh, Takayuki;Sasaki, Nobuo, 2023, CELL PROLIFERATION, 56, 6

  DOI
• Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression, Ishihara, Rei;Oda, Tsukasa;Murakami, Yuki;Matsumura, Ikuko;Watanabe, Saki;Asao, Yuta;Masuda, Yuta;Gotoh, Nanami;Kasamatsu, Tetsuhiro;Takei, Hisashi;Kobayashi, Nobuhiko;Sasaki, Nobuo;Saitoh, Takayuki;Murakami, Hirokazu;Handa, Hiroshi, 2023, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 3

  DOI
• DNA損傷誘導性細胞老化は液-液相分離で形成される53BP1核内フォーカスにより制御される(DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation), ;;;;;, Sep. 2023, 82回, 964
• 腸内細菌研究における腸管オルガノイド, ;, Jan. 2024, 81, 1, 51
• 【オルガノイドがもたらすライフサイエンス革命　あなたの研究に、どう使う?進化と深化を生む未来型研究30選】(第3章)オルガノイド生命医科学研究が生み出す新領域の萌芽　オルガノイドが切り拓く腸内細菌学の新時代, 佐々木 伸雄, Mar. 2024, 42, 5, 842
• Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice., Yamazaki Kyoko;Miyauchi Eiji;Kato Tamotsu;Sato Keisuke;Suda Wataru;Tsuzuno Takahiro;Yamada-Hara Miki;Sasaki Nobuo;Ohno Hiroshi;Yamazaki Kazuhisa, Aug. 2022, Journal of oral microbiology, 14, 1

  DOI
• DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation., Oda Tsukasa;Gotoh Nanami;Kasamatsu Tetsuhiro;Handa Hiroshi;Saitoh Takayuki;Sasaki Nobuo, Jan. 2023, Cell proliferation, 56, 6

  DOI
• Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression., Ishihara Rei;Oda Tsukasa;Murakami Yuki;Matsumura Ikuko;Watanabe Saki;Asao Yuta;Masuda Yuta;Gotoh Nanami;Kasamatsu Tetsuhiro;Takei Hisashi;Kobayashi Nobuhiko;Sasaki Nobuo;Saitoh Takayuki;Murakami Hirokazu;Handa Hiroshi, Jan. 2023, International journal of molecular sciences, 24, 3

  DOI
• D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease., Umeda Satoko;Sujino Tomohisa;Miyamoto Kentaro;Yoshimatsu Yusuke;Harada Yosuke;Nishiyama Keita;Aoto Yoshimasa;Adachi Keika;Hayashi Naoki;Amafuji Kimiko;Moritoki Nobuko;Shibata Shinsuke;Sasaki Nobuo;Mita Masashi;Tanemoto Shun;Ono Keiko;Mikami Yohei;Sasabe Jumpei;Takabayashi Kaoru;Hosoe Naoki;Suzuki Toshihiko;Sato Toshiro;Atarashi Koji;Teratani Toshiaki;Ogata Haruhiko;Nakamoto Nobuhiro;Shiomi Daisuke;Ashida Hiroshi;Kanai Takanori, Aug. 2023, Cellular and molecular gastroenterology and hepatology, 16, 6

  DOI
• 「食品成分による代謝調節研究の新展開-エネルギー代謝を中心に-」　オルガノイド技術が切り拓く腸内細菌・栄養学研究, 佐々木 伸雄, Mar. 2023, 77回, 149
• HIF-1αの安定化剤を用いた模擬低酸素環境下における多発性骨髄腫細胞の遺伝子発現解析, ;;;;;;;;;;;;;, Aug. 2023, 73, 3, 254
• 大腸上皮幹細胞ニッチであるDeep Crypt Secretory(DCS)細胞の細胞系譜解析, ;;;;, Aug. 2023, 73, 3, 254
• ムチン層の制御に関与する腸内細菌の探索, ;;;;, Aug. 2023, 73, 3, 255
• ヒト回腸由来オルガノイドを利用した胆汁酸トランスポーターASBTの発現解析, ;;;;;, Aug. 2023, 73, 3, 260
• 【腸内デザインに向けた代謝物質の機能理解】腸内代謝物質を介した免疫系の修飾, ;, Aug. 2023, 95, 4, 475
• デフェロキサミンによるHIF-1安定化を介した多発性骨髄腫における遺伝子発現変動の解析, ;;;;;;;;;;;;;, Oct. 2022, 84回, 1177
• DNA損傷誘導性細胞老化は液-液相分離で形成される53BP1核内フォーカスにより制御される(DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation), ;;;;;, Sep. 2023, 82回, 964
• 腸内細菌研究における腸管オルガノイド, ;, Jan. 2024, 81, 1, 51
• 【オルガノイドがもたらすライフサイエンス革命　あなたの研究に、どう使う?進化と深化を生む未来型研究30選】(第3章)オルガノイド生命医科学研究が生み出す新領域の萌芽　オルガノイドが切り拓く腸内細菌学の新時代, 佐々木 伸雄, Mar. 2024, 42, 5, 842
• 【腸内細菌研究における動物実験代替法の現状】ヒト大腸オルガノイドを用いた腸内細菌との共培養研究, ;;, Jul. 2024, 38, 3, 157
• "幹細胞学・再生医学を切り拓くオルガノイド培養法", 佐々木 伸雄, Aug. 2022, 72, 3, 298
• 大腸上皮幹細胞ニッチであるDCS細胞の細胞系譜解析, ;;;;, Aug. 2022, 72, 3, 320
• 「食品成分による代謝調節研究の新展開-エネルギー代謝を中心に-」　オルガノイド技術が切り拓く腸内細菌・栄養学研究, 佐々木 伸雄, Mar. 2023, 77回, 149
• デフェロキサミンによるHIF-1安定化を介した多発性骨髄腫における遺伝子発現変動の解析, ;;;;;;;;;;;;;, Oct. 2023, 85回, 1177

MISC

• 腸内環境を自在にデザインする未来の創生を目指し, 佐々木　伸雄, 01 Feb. 2023, The Kitakanto Medical Journal, 73, 91, 92
• 腸内細菌-宿主細胞の相互作用メカニズムを紐解く新規共培養系の開発, 佐々木　伸雄, 2021, 75, 1, 77, 81, Introduction scientific journal
• 腸オルガノイド, 佐々木 伸雄,　小田　司，佐藤　俊朗, 76, 5, 471, 477, Introduction scientific journal
• Intra-tumor diversification in colorectal cancer at the single-cell level, Nobuo Sasaki; Hans Clevers, 2019, Clinical immunology & allergology, 71, 1, 86, 91
• 大腸がんにおいて1細胞のレベルで明らかにされた単一の腫瘍における不均一性, 佐々木 伸雄; Hans Clevers, 2018
• Maintaining Colon Homeostasis by Controlling Intestinal Stem Cell., Nobuo Sasaki; Hans Clevers, Oct. 2016, Clinical Immunology & Allergology, 66, 4, 407, 412

Books etc

• オルガノイドを用いた解析, Contributor, 25 Nov. 2022, 113-117
• オルガノイド実験スタンダード : 決定版 : 開発者直伝!珠玉のプロトコール集, Contributor, Apr. 2019, 368p, ISBN: 9784758122399
• Biology and Engineering of Stem Cell Niches, Contributor, Ajaykumar Vishwakarma; Jeffrey Karp, Chapter 8 - Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids, Apr. 2017
• 再生医療と疾患解明の鍵となる組織幹細胞 : 生体内の維持・分化制御からオルガノイド形成、がん・幹細胞疾患まで, Contributor, Nov. 2016, 196p, ISBN: 9784758103589
• 生物機能モデルと新しいリソース・リサーチツール, Contributor, Feb. 2011, 671p, ISBN: 9784900487482
• 糖鎖科学の新展開 : 機能解明・次世代型材料・医薬品開発に向けて, Contributor, Aug. 2005, 2, 4, 11, 536, 15, 20p, 図版14p, ISBN: 4860430816

Presentations

• オルガノイドを利用した内分泌学・腸内細菌研究のススメ, 佐々木　伸雄, 第36回　日本糖尿病・肥満動物学会年次学術集会, 17 Feb. 2023
• 佐々木　伸雄, Toward the establishment of Gut Design Science ~ Developing new ideas based on the past study, 01 Dec. 2022
• DNA損傷誘導性の細胞老化は液ー液相分離で形成される53BP1 nuclar fociにより制御される, 小田司，後藤七海， 笠松哲光，半田寛， 齋藤貴之， 佐々木伸雄, 第45回日本分子生物学会年会, 30 Nov. 2022
• 新技術が切り拓く今後の腸内細菌研究, 佐々木　伸雄, 第2回腸内デザイン学会, 15 Nov. 2022
• 第2回腸内デザイン学会, 15 Nov. 2022
• Cigarette smoking modulates colonic mucosal microbiota and immune responses in patients with inflammatory bowel diseases, Eiji Miyauchi, Nobuo Sasaki, Hiroshi Ohno, The 8th IMCR Symposium on Endocrine and Metabolism, 10 Nov. 2022
• DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation, Tsukasa Oda, Nobuo Sasaki, The 8th IMCR Symposium on Endocrine and Metabolism, 10 Nov. 2022
• 大腸上皮幹細胞ニッチであるDeep Crypt Sedretory細胞の細胞系譜解析, 青柳　瑠南, 佐々木　伸雄, 第69回北関東医学会総会, 29 Sep. 2022
• 生体調節研究所における癌研究, 佐々木　伸雄，小田　司, 第81回日本癌学会学術総会, 29 Sep. 2022
• オルガノイドが紐解く消化管の複雑性, 佐々木　伸雄, 第26回腸内細菌学会, 08 Jul. 2022
• オルガノイドが切り拓くHuman Biologyの新時代, 佐々木　伸雄, 第45回セルセラピーセミナー, 15 Apr. 2022
• 幹細胞学・再生医学を切り拓くオルガノイド培養法, 佐々木　伸雄, 第89回日本泌尿器科学会群馬地方会, 19 Feb. 2022, 19 Feb. 2022, 19 Feb. 2022, Japanese, Japan
• Toward coherent design of host bacterial symbiosis, 佐々木　伸雄, 第44回日本分子生物学会, 02 Dec. 2021, 01 Dec. 2021, 03 Dec. 2021, English, Japan
• オルガノイドが切り拓く腸内細菌研究, 佐々木　伸雄, 第一回腸内デザイン学会, 18 Nov. 2021, 18 Nov. 2021, 18 Nov. 2021, Japanese, Japan
• オルガノイドが切り拓く腸内細菌研究, 佐々木　伸雄, 2021年度第4回生活習慣病予防のための機能性食品開発に関する研究会, 11 Nov. 2021, 11 Nov. 2021, 11 Nov. 2021, Japanese, Japan
• 本当のところオルガノイドって何？, 佐々木　伸雄, 群馬大学生体調節研究所ランチョンセミナー, 26 Oct. 2021, 26 Oct. 2021, 26 Oct. 2021, Japanese, Japan
• オルガノイドが切り拓く腸内細菌研究, 佐々木　伸雄, 第20回生体機能研究会, 15 Oct. 2021, 15 Oct. 2021, 16 Oct. 2021, Japanese, Japan
• オルガノイドが切り拓く腸内細菌研究の新時代, 佐々木　伸雄, 第7回内分泌・代謝シンポジウム, 09 Sep. 2021, 09 Sep. 2021, 10 Sep. 2021, Japanese, Japan

Awards

• 2017
• 2012
• 2011
• 2010

Research Projects

• 01 Apr. 2022, 31 Mar. 2030, Principal investigator, Competitive research funding
• 01 Dec. 2021, 31 Mar. 2027, Principal investigator, Competitive research funding
• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Keio University, Apr. 2019, Mar. 2023, 19H03455
• Apr. 2017, Mar. 2022, Principal investigator, Competitive research funding
• Oct. 2016, Mar. 2022, Coinvestigator
• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Keio University, Jun. 2019, Mar. 2021, 19K22544
• A novel culture system of intestinal epithelium for study the interaction among microbiome-host epithelium-immune cells, Sasaki Nobuo; SATO Toshiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Keio University, Apr. 2017, Mar. 2019, As organoids cultured in the original method represent 3D structures, the gut microbiome is needed to transplant inside of organoid by microinjection to study the mechanism of their interaction. However, this microinjection on organoid is intrusive and required for high skill. Here, we developed a novel monolayer culture of the intestinal epithelium by some modification of an original recipe. Using this culture condition, the human normal intestinal epithelial cells were cultured containing not only stem cell, but also every functional differentiated cell such as enterocyte, goblet cell, and enteroendocrine cell. Therefore, this culture method of the monolayered human gut epithelium represented the almost same physiological condition of the gut in our body in the dish, and we strongly emphasized it is a very easy system to study the interaction mechanism between host cells and bacteria., 17K15968

  対象リソースIRI
• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, Grant-in-Aid for Research Activity Start-up, Keio University, Aug. 2016, Mar. 2018, 16H07176
• Jan. 2012, Dec. 2013, Principal investigator, Competitive research funding
• Jan. 2011, Dec. 2011, Principal investigator, Competitive research funding
• Apr. 2010, Mar. 2011, Principal investigator, Competitive research funding
• Principal investigator, Competitive research funding

Academic Contribution

• Feb. 2112, Feb. 2112

Social Contribution

Social Contribution

• Symposium of Frontiers in Mammalian Development, 03 Mar. 2023　(Target:　Graduate students, Teachers, Researchers)
• オルガノイドが切り拓くHuman Biologyの新時代, 13 Jan. 2023　(Target:　Company)
• 最先端生命科学＆重粒子線医学セミナー, 11 Mar. 2023　(Target:　High school students)
• 第2回腸内デザイン学会, 15 Nov. 2022

  添付ファイルのURL
• オルガノイド技術が切り拓く"ヒト"腸内細菌研究, 07 Nov. 2022　(Target:　Researchers, General, Company, Civic organization)
• 第4回生活習慣病予防のための機能性食品開発に関する研究会, 11 Nov. 2021　(Target:　Researchers, General, Company)
• 最先端生命科学＆重粒子線医学セミナー, Dec. 2203　(Target:　High school students)
• 福島県立相馬高等学校理数科　特別講義, 2201, Lecture　(Target:　High school students)

Media Coverage

• 高校生のための最先端生命科学＆重粒子線医学セミナー, Other than myself, 13 Mar. 2022, Paper