OZAKI HIROAKI

Department of Pure and Applied ScienceProfessor
Last Updated :2026/10/02

■Researcher basic information

Researcher

  • Name

    OZAKI HIROAKI

Affiliation

  • Department of Pure and Applied Science, Professor

Profile and Settings

  • Name

    HIROAKI, OZAKI

Author Article

  • H Ozaki
  • OZAKI H.

Foreign language

  • Use in presentation

    English

  • Use in publication

    English

Affiliation

  • Gunma University
  • Gunma University

Affiliation

  • 所属情報

    Graduate School of Science and Technology

  • Job title

    Professor

Education

  • 1989, Kyoto University, Graduate School, Division of Engineering
  • 1989, Kyoto University
  • 1984, Kyoto Institute of Technology, Faculty of Textile Science and Technology
  • 1984, Kyoto Institute of Technology

Degree

  • (BLANK), Kyoto University
  • (BLANK)

Professional Memberships

  • Japanese Society for Chemical Biology

Research History

  • 2013, 2014
  • 2014, Gunma University, Graduate School of Science and Technology
  • 2009, 2013
  • 2007, 2009
  • 2001, 2007, Gunma University
  • 1992, 2001, Gunma University
  • 1990, 1992, Boston College, Postdoctral Fellow

■Research activity information

Research Areas

  • Nanotechnology/Materials, Biochemistry

Research Interests

  • Nucleic acid Chemistry

Papers

  • Effects of C5-polycyclic aromatic substituent of pyrimidine nucleosides on the detection of specific bases in the DNA using fluorescence, Juri Kamimura; Hiroaki Ozaki, May 2025, CHEMISTRY LETTERS, 54, 5, Scientific journal
    DOI
  • DNA Cleavage by Bisphenanthroline-polyamine-acridine Conjugates, Masato Morimura; Yuuki Sunaga; Tomokazu Masuda; Hiroaki Ozaki, 05 Jul. 2022, Chemistry Letters, 51, 7, 768, 770, Scientific journal
    DOI
  • Porphyrins ameliorate spinocerebellar ataxia type 36 GGCCTG repeat expansion-mediated cytotoxicity, Kimitoshi Hirayanagi; Hiroaki Ozaki; Setsuki Tsukagoshi; Natsumi Furuta; Yoshio Ikeda, Oct. 2021, Neuroscience Research, 171, 92, 102, Scientific journal
    DOI
  • Synthesis of RNA bearing C5-polyamine modified pyrimidine nucleosides at the 3´-end by T4 RNA Ligase, Tomokazu Masuda; Shingo Kimura; Mohammad Mehedi Masud; Hiroaki Ozaki, Feb. 2019, Letters in Organic Chemistry, 16, 2, 122, 127
    DOI
  • Synthesis and properties of microenvironment-sensitive oligonucleotides containing a small fluorophore, 3-aminobenzonitrile or 3-aminobenzoic acid, Hiroaki Ozaki; Takeshi Kawai; Masayasu Kuwahara, Dec. 2017, TETRAHEDRON, 73, 51, 7177, 7184, Scientific journal
    DOI
  • Polymerase Reactions that Involve Modified Nucleotides, Masayasu Kuwahara; Kenta Hagiwara; Hiroaki Ozaki, 2016, RNA Technologies, 429, 453, In book
    DOI
  • Hepatocyte Nuclear Factor 4 alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver, Shunsuke Matsuo; Masayuki Ogawa; Martina U. Muckenthaler; Yumiko Mizui; Shota Sasaki; Takafumi Fujimura; Masayuki Takizawa; Nagayuki Ariga; Hiroaki Ozaki; Masakiyo Sakaguchi; Frank J. Gonzalez; Yusuke Inoue, Dec. 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865, Scientific journal
    DOI
  • Polymerase-mediated high-density incorporation of amphiphilic functionalities into DNA: Enhancement of nuclease resistance and stability in human serum, Hiroto Fujita; Kohsuke Nakajima; Yuuya Kasahara; Hiroaki Ozaki; Masayasu Kuwahara, Jan. 2015, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25, 2, 333, 336, Scientific journal
    DOI
  • Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers, Yuri Imaizumi; Yuuya Kasahara; Hiroto Fujita; Shunsuke Kitadume; Hiroaki Ozaki; Tamaki Endoh; Masayasu Kuwahara; Naoki Sugimoto, Jun. 2013, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 25, 9412, 9419, Scientific journal
    DOI
  • Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment Selection of Base- and Sugar-Modified DNA Aptamers: Target Binding Dominated by 2 '-O,4 '-C-Methylene-Bridged/Locked Nucleic Acid Primer, Yuuya Kasahara; Yuuta Irisawa; Hiroto Fujita; Aiko Yahara; Hiroaki Ozaki; Satoshi Obika; Masayasu Kuwahara, May 2013, ANALYTICAL CHEMISTRY, 85, 10, 4961, 4967, Scientific journal
    DOI
  • 2 ',4 '-BNA/LNA aptamers: CE-SELEX using a DNA-based library of full-length 2 '-O,4 '-C-methylene-bridged/linked bicyclic ribonucleotides, Yuuya Kasahara; Yuuta Irisawa; Hiroaki Ozaki; Satoshi Obika; Masayasu Kuwahara, Mar. 2013, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23, 5, 1288, 1292, Scientific journal
    DOI
  • Cleavage of Supercoiled Plasmid DNA by Phenanthroline-Polyamine Conjugates as a Metal-free Artificial Nuclease, Tomokazu Masuda; Takeshi Sasagase; Akiko N. Ozaki; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Jan. 2013, CHEMISTRY LETTERS, 42, 1, 86, 88, Scientific journal
    DOI
  • Structural and affinity analyses of G-quadruplex DNA aptamers for camptothecin derivatives, Hiroto Fujita; Yuri Imaizumi; Yuuya Kasahara; Shunsuke Kitadume; Hiroaki Ozaki; Masayasu Kuwahara; Naoki Sugimoto, 2013, Pharmaceuticals, 6, 9, 1082, 1093, Scientific journal
    DOI
  • Specific Amino Acid Sensing Using a Single Acridone-labeled DNA Aptamer, Hiroaki Ozaki; Yasuhisa Hagiwara; Masayasu Kuwahara, Sep. 2012, CHEMISTRY LETTERS, 41, 9, 917, 919, Scientific journal
    DOI
  • Nucleotide modification and polymerase engineering for creating a novel class of artificial nucleic acid aptamers, Y. Imaizumi; Y. Takano; S. Kitadume; H. Ozaki; S. Obika; M. Kuwahara, 2011, IFMBE Proceedings, 37, 1023, 1026, International conference proceedings
    DOI
  • Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3´-overhang regions and its RNAi activity, Mohammad Mehedi Masud; Tomokazu Masuda; Yusuke Inoue; Masayasu Kuwahara; Hiroaki Sawai; Hiroaki Ozaki, Jan. 2011, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717, Scientific journal
    DOI
  • Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates, Masayasu Kuwahara; Yuuki Takano; Yuuya Kasahara; Hiroki Nara; Hiroaki Ozaki; Hiroaki Sawai; Akio Sugiyama; Satoshi Obika, Nov. 2010, MOLECULES, 15, 11, 8229, 8240, Scientific journal
    DOI
  • Effect of 3´-end capping of aptamer with various 2´,4´-bridged nucleotides: Enzymatic post-modification toward a practical use of polyclonal aptamers, Yuuya Kasahara; Shunsuke Kitadume; Kunihiko Morihiro; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai; Takeshi Imanishi; Satoshi Obika, Mar. 2010, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 5, 1626, 1629, Scientific journal
    DOI
  • SYNTHESIS AND PROPERTIES OF OLIGODEOXYRIBONUCLEOTIDES BEARING A POLYAMINO GROUP AT THE 2 ' POSITION VIA 2 '-O-CARBAMOYLMETHYL AND 2 '-S-CARBAMOYLMETHYL GROUPS, Hiroaki Ozaki; Shingo Nomura; Shingo Momiyama; Kazuyuki Yokotsuka; Masayasu Kuwahara; Hiroaki Sawai, Oct. 2009, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 28, 10, 943, 952, Scientific journal
    DOI
  • Smart conferring of nuclease resistance to DNA by 3´-end protection using 2´,4´-bridged nucleoside-5´-triphosphates, Masayasu Kuwahara; Satoshi Obika; Hidetoshi Takeshima; Yoshihiko Hagiwara; Jun-ichi Nagashima; Hiroaki Ozaki; Hiroaki Sawai; Takeshi Imanishi, Jun. 2009, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19, 11, 2941, 2943, Scientific journal
    DOI
  • Transcription and reverse transcription of artificial nucleic acids involving backbone modification by template-directed DNA polymerase reactions, Masayasu Kuwahara; Hidetoshi Takeshima; Jun-ichi Nagashima; Satoshi Minezaki; Hiroaki Ozaki; Hiroaki Sawai, Jun. 2009, BIOORGANIC & MEDICINAL CHEMISTRY, 17, 11, 3782, 3788, Scientific journal
    DOI
  • Fluorescent properties of acridonyl group in DNA duplex., Masayasu Kuwahara; Atsushi Kobayashi; Masayoshi Tajima; Shunsuke Kitazume; Keisuke Anahara; Hiroaki Ozaki; Seiji Tobita, 2009, Nucleic acids symposium series (2004), 53, 137, 138, Scientific journal
    DOI
  • Acridone-labeled DNA aptamer for the detection of biomolecules., Hiroaki Ozaki; Yasuhisa Hagiwara; Hiromi Asakura; Masayasu Kuwahara, 2009, Nucleic acids symposium series (2004), 53, 255, 256, Scientific journal
    DOI
  • Effect of backbone-modification of oligodeoxyribonucleic acid on primer extension reactions, Masayasu Kuwahara; Satoshi Minezaki; Jun-ichi Nagashima; Hiroaki Ozaki; Hiroaki Sawai, Sep. 2008, Nucleic Acids Symp. Series, 52, 453, 454, Scientific journal
  • Synthesis and incorporation of fluorescent C-nucleoside analogue into oligodeoxyribonucleotides, Hiroaki Ozaki; Takeshi Kawai; Masayasu Kuwahara; Hiroaki Sawai, Sep. 2008, Nucleic Acids Symp. Series, 52
  • Systematic analysis of enzymatic DNA polymerization using oligo-DNA templates and triphosphate analogs involving 2 ',4 '-bridged nucleosides, Masayasu Kuwahara; Satoshi Obika; Jun-ichi Nagashima; Yuki Ohta; Yoshiyuki Suto; Hiroaki Ozaki; Hiroaki Sawai; Takeshi Imanishi, Aug. 2008, NUCLEIC ACIDS RESEARCH, 36, 13, 4257, 4265, Scientific journal
    DOI
  • Acridone-tagged DNA as a new probe for DNA detection by fluorescence resonance energy transfer and for mismatch DNA recognition, Yasuhisa Hagiwara; Tomoya Hasegawa; Atushi Shoji; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Jul. 2008, BIOORGANIC & MEDICINAL CHEMISTRY, 16, 14, 7013, 7020, Scientific journal
    DOI
  • Fluorescence-enhanced europium-diethylenetriaminepentaacetic (DTPA)-monoamide complexes for the assessment of renal function, Lori K. Chinen; Karen P. Galen; K. T. Kuan; Mary E. Dyszlewski; Hiroaki Ozaki; Hiroaki Sawai; Raghootama S. Pandurangi; Frederick G. Jacobs; Richard B. Dorshow; Raghavan Rajagopalan, Feb. 2008, JOURNAL OF MEDICINAL CHEMISTRY, 51, 4, 957, 962, Scientific journal
    DOI
  • Arginine-modified DNA aptamers that show enantioselective recognition of the dicarboxylic acid moiety of glutamic acid, Kazuomi Ohsawa; Toshiyuki Kasamatsu; Jun-ichi Nagashima; Kazuo Hanawa; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Jan. 2008, ANALYTICAL SCIENCES, 24, 1, 167, 172, Scientific journal
  • Synthesis of novel fluorescent nucleoside bearing 3-aminobenzonitrile as a nucleobase, Hiroaki Ozaki; Takahiro Setaka; Syouta, Tsuchiya; Takeshi Kawai; Masayasu Kuwahara; Hiroaki Sawai, Nov. 2007, Nucleic Acids Symp. Series, 51, 137, 138, Scientific journal
    DOI
  • Interaction with and cleavage of DNA by novel phenanthroline-polyamine derivative, Takeshi Sasagase; Takeshi Arai; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Nov. 2007, Nucleic Acids Symp. Series, 51, 51, 193, 194, Scientific journal
    DOI
  • Modified DNA aptamer that binds the (R)-Isomer of a thalidomide derivative with high enantioselectivity, Atsushi Shoji; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Feb. 2007, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 5, 1456, 1464, Scientific journal
    DOI
  • Chemico-enzymatic synthesis of a new fluorescent-labeled DNA by PCR with a thymidine nucleotide analogue bearing an acridone derivative, Atsushi Shoji; Tomoya Hasegawa; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Feb. 2007, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17, 3, 776, 779, Scientific journal
    DOI
  • Systematic characterization of 2 '-deoxynucleoside-5 '-triphosphate analogs as substrates for DNA polymerases by polymerase chain reaction and kinetic studies on enzymatic production of modified DNA, Masayasu Kuwahara; Jun-ichi Nagashima; Masatoshi Hasegawa; Takehiro Tamura; Rina Kitagata; Kazuo Hanawa; Shin-ichi Hososhima; Toshiyuki Kasamatsu; Hiroaki Ozaki; Hiroaki Sawai, Nov. 2006, NUCLEIC ACIDS RESEARCH, 34, 19, 5383, 5394, Scientific journal
    DOI
  • Assembly of DNA nanostructures with branched tris-DNA, Takahiro Kuroda; Yoshimasa Sakurai; Yukinao Suzuki; Akiko O. Nakamura; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Oct. 2006, CHEMISTRY-AN ASIAN JOURNAL, 1, 4, 575, 580, Scientific journal
    DOI
  • Biomolecular sensor based on fluorescence-labeled aptamer, Hiroaki Ozaki; Akifumi Nishihira; Masayuki Wakabayashi; Masayasu Kuwahara; Hiroaki Sawai, Aug. 2006, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 16, 4381, 4384, Scientific journal
    DOI
  • Direct PCR amplification of various modified DNAs having amino acids: Convenient preparation of DNA libraries with high-potential activities for in vitro selection, M Kuwahara; K Hanawa; K Ohsawa; R Kitagata; H Ozaki; H Sawai, Apr. 2006, BIOORGANIC & MEDICINAL CHEMISTRY, 14, 8, 2518, 2526, Scientific journal
    DOI
  • Synthesis and property of DNA labeled with fluorescent acridon, Tomoya Hasegawa; Atsusi Shoji; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, 2006, Nucleic Acids Symp. Series, 50, 145, 146, Scientific journal
    DOI
  • Screening of a glutamic acid-binding aptamer from arginine-modified DNA library, Masayasu Kuwahara; Kazuomi Ohsawa; Toshiyuki Kasamatsu; Atsushi Shoji; Hiroaki Sawai; Hiroaki Ozaki, 2005, Nucleic Acids Symp. Series, 49, 81, 82, Scientific journal
    DOI
  • Comparison study on PCR amplification of modified DNA by using various kinds of polymerase and modified nucleoside triphosphates, Masayasu Kuwahara; Takehiro Tamura; Rina Kitagata; Hiroaki Sawai; Hiroaki Ozaki, 2005, Nucleic Acids Symp. Series,, 49, 275, 276, Scientific journal
    DOI
  • Selective binding and cleavage of DNA by Stereoisomers of N,N'-bis(phenanthrolin-2-yl)-1,2cyclohexanediamine conjugates, and their copper complexes, K Hayashi; R Nakajima; Kiyosawa, I; H Ozaki; H Sawai, Jun. 2004, CHEMISTRY LETTERS, 33, 6, 684, 685, Scientific journal
    DOI
  • Bis(phenanthroline)-ethylenediamine conjugate displays excimer fluorescence upon binding with DNA, K Hayashi; H Akutsu; H Ozaki; H Sawai, Jun. 2004, CHEMICAL COMMUNICATIONS, 1386-1387, 12, 1386, 1387, Scientific journal
  • Effect of imino group of a linker arm at the C5 position of a pyrimidine nucleoside on the thermal stabilities of DNA/DNA and DNA/RNA duplexes (vol 23, pg 339, 2004), H Ozaki; M Mine; K Shinozuka; H Sawai, May 2004, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 23, 5, 823, 823
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  • Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX, MM Masud; M Kuwahara; H Ozaki; H Sawai, Mar. 2004, BIOORGANIC & MEDICINAL CHEMISTRY, 12, 5, 1111, 1120, Scientific journal
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  • Synthesis and antisense properties of oligodeoxyribonucleotides containing C5-substituted arabinofurnosyluracil, H Ozaki; K Nakajima; M Kuwahara; H Sawai, Mar. 2004, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 5, 1115, 1118, Scientific journal
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  • Detection of biomolecule by aptamer beacon, Akifumi Nishihira; Hiroaki Ozaki; Masayuki Wakabayashi; Masayasu Kuwahara; Hiroaki Sawai, 2004, Nucleic Acids Symp. Series, 48, 135, 136, Scientific journal
  • Screening of modified DNA aptamers that recognize DNA secondary structure, Masayasu Kuwahara; Toshiyuki Kasamatsu; Masatoshi Hasegawa; Atsushi Shoji; Hiroaki Ozaki; Hiroaki Sawai, 2004, Nucleic Acids Symp. Series, 48, 265, 266, Scientific journal
  • Effect of imino group of a linker arm at the C5 position of a pyrimidine nucleoside on the thermal stabilities of DNA/DNA and DNA/RNA duplexes, H Ozaki; M Mine; K Shinozuka; H Sawai, Jan. 2004, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 23, 1-2, 339, 346, Scientific journal
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  • Substrate properties of C5-substituted pyrimidine 2 '-deoxynucleoside 5 '-triphosphates for thermostable DNA polymerases during PCR, M Kuwahara; Y Takahata; A Shoji; AN Ozaki; H Ozaki; H Sawai, Nov. 2003, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 13, 21, 3735, 3738, Scientific journal
    DOI
  • Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA, H Ozaki; K Nakajima; K Tatsui; C Izumi; M Kuwahara; H Sawai, Aug. 2003, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 13, 15, 2441, 2443, Scientific journal
    DOI
  • Modified DNA bearing 5-(methoxycarbonyl-methyl)-2 '-deoxyuridine: Preparation by PCR with thermophilic DNA polymerase and post-synthetic derivation, MM Masud; A Ozaki-Nakamura; M Kuwahara; H Ozaki; H Sawai, Jul. 2003, CHEMBIOCHEM, 4, 7, 584, 588, Scientific journal
    DOI
  • Simultaneous incorporation of three differentmodified nucleotides during PCR, Masayasu Kuwahara; Shin-ichi Hososhima; Yumi Takahata; Rina Kitagata; Atsushi Shoji; Kazuo Hanawa; Akiko N; Ozaki; Hiroaki Ozaki; Hiroaki Sawai, 2003, Nucleic Acids Res. Supplement,, 3, 37, 38, Scientific journal
    DOI
  • Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted arabinofuranosyluracils, Hiroaki Ozaki; Kiyohiro Nakajima; Kyoko Yajima; Kaoru Tatsui; Masayasu Kuwahara; Hiroaki Sawai, 2003, Nucleic Acids Res. Supplement, 3, 59, 60, Scientific journal
  • Synthesis of modified DNAs bearing two different fluorescent probes and its application to fluorescence resonance energy transfer, H Ozaki; H Kobari; K Takagi; H Sawai, 2003, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 22, 5-8, 1219, 1221, Scientific journal
    DOI
  • Enzymatic synthesis of labeled DNA by PCR using new fluorescent thymidine nucleotide analogue and superthermophilic KOD Dash DNA polymerase, T Obayashi; MM Masud; AN Ozaki; H Ozaki; M Kuwahara; H Sawai, Apr. 2002, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 12, 8, 1167, 1170, Scientific journal
  • Synthesis of new modified DNAs by hyperthermophilic DNA polymerase: Substrate and template specificity of functionalized thymidine analogues bearing an sp3-hybridized carbon at the C5 alpha-position for several DNA polymerases, H Sawai; A Ozaki-Nakamura; M Mine; H Ozaki, Mar. 2002, BIOCONJUGATE CHEMISTRY, 13, 2, 309, 316, Scientific journal
    DOI
  • Enzymatic incorporation of chemically-modified nucleoside into DNAs, Masayasu Kuwahara; Tsutomu Ohbayashi; Kazuo Hanawa; Atsushi Shoji; Akiko N. Ozaki; Hiroaki Ozaki; Hiroaki Sawai, 2002, Nucleic Acids Res. Supplement,, 2, 83, 84, Scientific journal
    DOI
  • Modified DNA aptamers against sweet agent aspartame, Hiroshi Saitoh; Akiko Nakamura; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, 2002, Nucleic Acids Res. Supplement, 2, 215, 216, Scientific journal
    DOI
  • Expansion of structural and functional diversities of DNA using new 5-substituted deoxyuridine derivatives by PCR with superthermophilic KOD Dash DNA polymerase, H Sawai; AN Ozaki; F Satoh; T Ohbayashi; MM Masud; H Ozaki, Dec. 2001, CHEMICAL COMMUNICATIONS, 24, 2604, 2605, Scientific journal
    DOI
  • Effect of the terminal amino group of a linker arm and its length at the C5 position of a pyrimidine nucleoside on the thermal stability of DNA duplexes, H Ozaki; M Mine; Y Ogawa; H Sawai, Aug. 2001, BIOORGANIC CHEMISTRY, 29, 4, 187, 197, Scientific journal
  • Enzymatic synthesis of modified DNA by PCR., M. M. Masud; A. Ozaki-Nakamura; F. Satou; T. Ohbayashi; H. Ozaki; H. Sawai, 2001, Nucleic acids research. Supplement (2001), 1, 21, 22, Scientific journal
    DOI
  • Post-synthetic functionalization of oligodeoxyribonucleotides at the 2 '-position, H Ozaki; S Momiyama; K Yokotsuka; H Sawai, Jan. 2001, TETRAHEDRON LETTERS, 42, 4, 677, 680, Scientific journal
  • Sensitization of Europium(III) luminescence by DTPA derivatives, H Ozaki; E Suda; T Nagano; H Sawai, Apr. 2000, CHEMISTRY LETTERS, /,312-313, 4, 312, 313, Scientific journal
  • Synthesis of oligodeoxyribonucleotide bearing 2 '-S-alkyl residue and its effect on the duplex stability, H Ozaki; Y Sato; S Azuma; H Sawai, 2000, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 19, 3, 593, 601, Scientific journal
  • Labeling of phosphorothioate antisense oligonucleotides with yttrium-90, Naoyuki Watanabe; Hiroaki Sawai; Keigo Endo; Kazuo Shinozuka; Hiroaki Ozaki; Shuji Tanada; Hajime Murata; Yasuhito Sasaki, Feb. 1999, Nuclear Medicine and Biology, 26, 2, 239, 243, Scientific journal
    DOI
  • Effect of acridine with various linker arms attached to C5 position of 2 '-deoxyuridine on the stability of DNA/DNA and DNA/RNA duplexes, H Ozaki; Y Ogawa; M Mine; H Sawai, 1998, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 17, 5, 911, 923, Scientific journal
  • Detection of DNA bending in a DNA-PAP1 protein complex by fluorescence resonance energy transfer, H Ozaki; N Iwase; H Sawai; T Kodama; Y Kyogoku, Feb. 1997, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 231, 3, 553, 556, Scientific journal
    DOI
  • Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique., S. Kohgo; A. Umeda; H. Ozaki; K. Shinozuka; H. Sawai, 1997, Nucleic acids symposium series, 37, 29, 30, Scientific journal
  • Synthesis and ribonuclease H related biochemical properties of α-anomeric 2'-deoxypyrimidine homooligomer and its phosphorothioate analog, Kazuo Shinozuka; Nobuaki Yamada; Akiko Nakamura; Hiroaki Ozaki; Hiroaki Sawai, 06 Aug. 1996, Bioorganic and Medicinal Chemistry Letters, 6, 15, 1843, 1848, Scientific journal
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  • NOVEL C5-SUBSTITUTED 2'-DEOXYURIDINE DERIVATIVES BEARING AMINO-LINKER ARMS - SYNTHESIS, INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES, AND THEIR HYBRIDIZATION PROPERTIES, H OZAKI; A NAKAMURA; M ARAI; M ENDO; H SAWAI, Jul. 1995, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 68, 7, 1981, 1987, Scientific journal
  • Double and triple helix formation of 2'-5' and 3'-5' oligonucleotides., J. Seki; K. Kuroda; H. Ozaki; H. Sawai, 1993, Nucleic acids symposium series, 29, 71, 72, Scientific journal
  • THE ESTIMATION OF DISTANCES BETWEEN SPECIFIC BACKBONE-LABELED SITES IN DNA USING FLUORESCENCE RESONANCE ENERGY-TRANSFER, H OZAKI; LW MCLAUGHLIN, Oct. 1992, NUCLEIC ACIDS RESEARCH, 20, 19, 5205, 5214, Scientific journal
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  • SITE-SPECIFIC LABELING OF DNA-SEQUENCES CONTAINING PHOSPHOROTHIOATE DIESTERS, JA FIDANZA; H OZAKI; LW MCLAUGHLIN, Jul. 1992, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 114, 14, 5509, 5517, Scientific journal
  • SYNTHESES AND PROPERTIES OF OLIGOTHYMIDYLATE ANALOGS CONTAINING STEREOREGULATED PHOSPHOROMORPHOLIDATE AND PHOSPHODIESTER LINKAGES IN AN ALTERNATING MANNER, H OZAKI; M KITAMURA; K YAMANA; A MURAKAMI; T SHIMIDZU, Jul. 1990, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 63, 7, 1929, 1936, Scientific journal
  • Effect of C5-polycyclic aromatic substituent of pyrimidine nucleosides on the detection of specific bases in the DNA using fluorescence, Juri Kamimura, Hiroaki Ozaki, No, Yes, Yes, 26 May 2025, Chemistry Letters, 54, 5, upaf102-1, upaf102-5, Scientific journal
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  • DNA Cleavage by Bisphenanthroline-polyamine-acridine Conjugates, Morimura, Masato;Sunaga, Yuuki;Masuda, Tomokazu;Ozaki, Hiroaki, Yes, 2022, CHEMISTRY LETTERS, 51, 7, 768, 770, Scientific journal
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  • Porphyrins ameliorate spinocerebellar ataxia type 36 GGCCTG repeat expansion-mediated cytotoxicity, Kimitoshi Hirayanagi, Hiroaki Ozaki, Setsuki Tsukagoshi, Natsumi Furuta, Yoshio Ikeda, No, No, No, Oct. 2021, Neuroscience Research, 171, 92, 102, Scientific journal
    DOI
  • Immobilization of Lanthanide Ion Chelates on DNA and Their Luminescence Properties, OZAKI H.;MATSUZAWA N.;SUDA E.;SAWAI H., May 1997, 30, 358, 359
  • Structural and affinity analyses of g-quadruplex DNA aptamers for camptothecin derivatives., Fujita Hiroto;Imaizumi Yuri;Kasahara Yuuya;Kitadume Shunsuke;Ozaki Hiroaki;Kuwahara Masayasu;Sugimoto Naoki, 29 Aug. 2013, Pharmaceuticals (Basel, Switzerland), 6, 9
    DOI
  • Acridone-labeled DNA aptamer for the detection of biomolecules., Ozaki Hiroaki;Hagiwara Yasuhisa;Asakura Hiromi;Kuwahara Masayasu, 2009, Nucleic acids symposium series (2004), 53
    DOI

Misc.

  • Synthesis and properties of oligonucleotides containing 5-substituted pyrimidine nucleoside, H Ozaki; M Kuwahara; H Sawai, Dec. 2004, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 62, 12, 1238, 1248, Introduction scientific journal
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  • Multi-functionalization of oligodeoxynucleotide: a facile post-synthetic modification technique for the preparation of oligodeoxynucleotides with two different functional molecules, K Shinozuka; S Kohgo; H Ozaki; H Sawai, 2000, CHEMICAL COMMUNICATIONS, /,59-60, 1, 59, 60
    DOI
  • Specific interaction between fluorescence-labeled DNA and nucleotide excision repair enzymes, UvrA and UvrB, from an extremely thermophilic bacterium, YAMAGATA Atsushi; NAKAGAWA Noriko; KATO Ryuichi; MASUI Ryoji; OZAKI Hiroaki; SAWAI Hiroaki; FUKUYAMA Keiichi; KURAMITSU Seiki, 01 Dec. 1998, 21, 374, 374
  • Non-enzymatic, template-directed ligation of 2 '-5 ' oligoribonucleotides. Joining of a template and a ligator strand, H Sawai; S Totsuka; K Yamamoto; H Ozaki, Jun. 1998, NUCLEIC ACIDS RESEARCH, 26, 12, 2995, 3000
    DOI
  • Synthesis of a novel 2 '-deoxyuridine derivative bearing a cyanomethoxycarbonylmethyl group at C-5 position and its use for versatile post-synthetic functionalization of oligodeoxyribonucleotides, S Kohgo; K Shinozuka; H Ozaki; H Sawai, Jun. 1998, TETRAHEDRON LETTERS, 39, 23, 4067, 4070
    DOI
  • Immobilization of Lanthanide Ion Chelates on DNA and Their Luminescence Properties, OZAKI H.; MATSUZAWA N.; SUDA E.; SAWAI H., 22 May 1997, 30, 358, 359
  • Double and Triple Helix Formation of 2′-5′ and 3′-5′ Linked Oligoribonucleotides. A Factor for Selective Advantage of Linkage Isomers of RNA, SAWAI Hiroaki; SEKI Junichi; OZAKI Hiroaki, Mar. 1997, 25, 1, 18, 18
  • Conformational and stacking properties of 3'-5' and 2'-5' linked oligoribonucleotides studied by CD, H Sawai; K Kuroda; J Seki; H Ozaki, Aug. 1996, BIOPOLYMERS, 39, 2, 173, 182
    DOI

Books and Other publications

  • 中分子創薬に資するペプチド・核酸・糖鎖の合成技術, Joint work, 萩原健太; 尾崎広明; 桒原正靖, Feb. 2018
  • Modified Nucleic Acids in Biology and Medicine, Joint work, Springer, International Publishing, 2016, 429-453, Scholarly book, 9783319341750
  • Frontiers in Organic Chemistry, Volume 1, Joint work, Hiroaki Ozaki; Masayasu Kuwahara; Hiroaki Sawai; Rahman, E, Oligonucleotides bearing a 5-substituted pyrimidine nucleoside; their synthesis, properties, and application, Bentham Science Publishers, 2005, 63-78, Scholarly book, 9077527060
  • Single work, 2003
  • 気軽に化学, Joint work, 群馬大学工学部化学系学科編, 上毛新聞社, 1996

Presentations

  • Synthesis and properties of fluorescent C5-aryl-2′-deoxyuridines and their incorporation into oligodeoxyribonucleotides, Juri Kamimura; Runa Ishikawa; Hiroaki Ozaki, The 46st International Symposium on Nucleic Acids Chemistry；ISNAC2019, 30 Nov. 2019, Tokyo, Japan
  • 08 Dec. 2018
  • Development of nucleic acid materials for gene mutation diagnosis, Yuka Kataoka; Kenta Hagiwara; Hiroaki Ozaki; Yasuyo Nakajima; Masanobu Yamada, 5th International Synposium of Gunma Unversity Medical Innovation and 9th International Conference on Advanced Mivro-Device Engineering, 06 Dec. 2018, Kiryu
  • Synthesis and fluorescence properties of C5-aryl-2′-deoxyuridine derivatives, Hiroaki Ozaki; Runa Ishikawa; Masato Abe; Yusuke Kuribara; Syouta Mamyouda, The 44st International Symposium on Nucleic Acids Chemistry；ISNAC2017, 15 Nov. 2017, Tokyo, Japan
  • Dec. 2015, Japanese
  • 12 Dec. 2014
  • Cleavage of DNA by phenanthroline-polyamine-acridine conjugates, Hiroaki Ozaki; Masato Morimura; Yuuki Sunaga; Tomokazu Masuda, The 41st International Symposium on Nucleic Acids Chemistry；ISNAC2014, 05 Nov. 2014, Kitakyushu, Japan
  • 23 Mar. 2013
  • 23 Mar. 2013
  • 2013
  • Study on binding properties of modified DNA aptamers that bind to CPT derivatives, Masayasu Kuwahara; Yuri Imaizumi; Yuuya Kasahara; Shunsuke Kitadume; Hiroaki Ozaki, The 39th International Symposium on Nucleic Acids Chemistry；ISNAC2012, 16 Nov. 2012, Nagoya, JAPAN
  • 2012
  • 2012
  • 2012
  • 10 Dec. 2011
  • 10 Dec. 2011
  • Synthesis of 1,10-phenanthroline with a silyl group and Ir(III) cyclometalated complexes, Saki Komoto; Takuya Hamada; Tomokazu Masuda; Keigo Fugami; Hiroaki Ozaki, First International Symposium on Element Inovatio, 09 Dec. 2011, Kiryu, Gunma
  • 13 Sep. 2011
  • 01 Sep. 2011
  • 22 Nov. 2010
  • Synthesis of modified siRNA and its activity for gene regulation, Mohammad Mehedi Masud; ○Tomokazu Masuda; Yusuke Inoue; Hiroaki Ozaki, The 37th International symposium on Nucleic Acid Chemistry 2010, 11 Nov. 2010, Yokohama, JAPAN
  • 30 Aug. 2010
  • 15 May 2010
  • 28 Mar. 2010
  • 28 Mar. 2010
  • 28 Mar. 2010
  • 05 Dec. 2009
  • 05 Dec. 2009
  • Fluorescent properties of acrydonyl group in DNA duplex, Masayasu Kuwahara; Ataushi Kobayashi; Masayoshi Tajima; Shunsuke Kitazume; Keisuke Anahara; Hiroaki Ozaki; Seiji Tobita, The 6th International symposium on Nucleic Acid Chemistry, 28 Sep. 2009, Gifu, Japan
  • Acridone-labeled DNA aptamer for the detection of biomolecules, Hiroaki Ozaki; Yasuhisa Hagiwara; Hiromi Asakura; Masayasu Kuwahara, The 6th International symposium on Nucleic Acid Chemistry, 28 Sep. 2009, Gifu, Japan
  • 14 Sep. 2009
  • 04 Sep. 2009
  • 04 Sep. 2009
  • 04 Sep. 2009
  • 27 Mar. 2009
  • 27 Mar. 2009
  • 27 Mar. 2009
  • 27 Mar. 2009
  • 18 Sep. 2008
  • 18 Sep. 2008
  • Effect of backbone-modification of oligodeoxyribonucleic acid on primer extension reactions, Masayasu Kuwahara; Satoshi Minezaki; Jun-ichi Nagashima; Hiroaki Ozaki; Hiroaki Sawai, Joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry, 09 Sep. 2008, Kyoto
  • Synthesis and incorporation of fluorescent C-nucleoside analogue into oligodeoxyribonucleotides, Hiroaki Ozaki; Takeshi Kawai; Masayasu Kuwahara; Hiroaki Sawai, Joint Symposium of 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and 35th International Symposium on Nucleic Acids Chemistry, 09 Sep. 2008, Kyoto
  • Mar. 2008
  • Mar. 2008
  • Mar. 2008
  • Mar. 2008
  • Fluorescence-enhanced europium complexes for the assessment of renal function, L. K. Chinen; K. P. Galen; K. T. Kuan; M. E. Dyszlewski; H. Ozaki; H. Sawai; R. Pandurangi; F. E. jacobs; R. B. Dorshow; R. Rajagopalan, SPIE Photonic WEST, Jan. 2008, San Jose, California, USA
  • Synthesis of novel fluorescent nucleoside bearing 3-aminobenzonitrile as a nucleobase, Hiroaki Ozaki; Takahiro Setaka; Syouta, Tsuchiya; Takeshi Kawai; Masayasu Kuwahara; Hiroaki Sawai, Fifth International Synposium on Nucleic Acids Chemistry, Nov. 2007, Tokyo
  • Interaction with and cleavage of DNA by novel phenanthroline-polyamine derivative, Takeshi Sasagase; Takeshi Arai; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, Fifth International Synposium on Nucleic Acids Chemistry, Nov. 2007, Tokyo
  • Fluorescence-enhanced europium complexes for the assessment of renal function, R. Rajagopalan; L. K. Chinen; K. P. Galen; K. T. Kuan; M. E. Dyszlewski; H. Ozaki; H. Sawai; R. Pandurangi; F. E. jacobs; R. B. Dorshow, Contrast Media Research CMR2007, 18 Oct. 2007, Banff, Canada
  • 27 Sep. 2007
  • 27 Sep. 2007
  • Sep. 2007
  • Synthesis of sugar modified DNA by chemical and enzymatic method, Takahiro Shimizu; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, The 2nd Gunma International Symposium on Chemistry, 21 Jul. 2007, Kiryu, Gunma
  • Substrate property and incorporation accuracy of various dATP analogs during enzymatic polymerization, Yoshiyuki Suto; Satoshi Minezaki; Rina Kitakata; Jun-ichi Nagashima; Masayasu Kuwahara; Hiroaki Ozaki; Hiroaki Sawai, The "nd Gunma International Symposium on Chemistry, 21 Jul. 2007, Kiryu, Gunma
  • Synthesis and Properties of Novel Fluorescent Nucleoside Analog Bearing 3-Aminobenzonitrile, Hiroaki Ozaki; Syouta Tsuchiya; Takahiro Setaka; Takeshi Kawai; Masayasu Kuwahara; Hiroaki Sawai, The 2nd Gunma International Symposium on Chemistry, 21 Jul. 2007, kiryu, Gunma
  • 28 Mar. 2007
  • 28 Mar. 2007
  • 25 Mar. 2007
  • 25 Mar. 2007
  • 25 Mar. 2007
  • Synthesis and property of DNA labeled with fluorescent acridone, Nov. 2006
  • Mar. 2006
  • Mar. 2006
  • Synthesis of oligodeoxyribonucleotides containing C5-substituted arabinofuranosyluracil by post-synthetic modification, PACIFICHEM 2005, Dec. 2005
  • Kinetic studies on primer extension reactions by using C5-modified analog of thymidine, Masayasu Kuwahara; Masatoshi Hasegawa; Jun-ichi Nagashima; Hiroaki Sawai; Hiroaki Ozaki, PACIFICHEM 2005, Dec. 2005, Hawaii
  • Nov. 2005
  • Sep. 2005
  • Comparison study on PCR amplification of modified DNA by using various kinds of polymerase and modified nucleoside triphosphate, Masayasu Kuwahara; Takehiro Tamura; Rina Kitagata; Hiroaki Sawai; Hiroaki Ozaki, The 4th International Symposium on Nucleic Acids Chemistry(2005), Sep. 2005, Fukuoka
  • Screening of a glutamic acid-binding aptamer from arginine-modified DNA library, Masayasu Kuwahara; Kazuomi Ohsawa; Toshiyuki Kasamatsu; Atsushi Shoji; Hiroaki Sawai; Hiroaki Ozaki, The 4th International Symposium on Nucleic Acids Chemistry(2005), Sep. 2005, Fukuoka
  • Mar. 2005
  • Mar. 2005
  • Detection of biomolecule by aptamer beacon, Nov. 2004
  • Detection of a Small Biomolecule by DNA Aptamer Beacon, Hiroaki Ozaki; Akifumi Nishihira; Masayuki Wakabayashi; Masayasu Kuwahara; Hiroaki Sawai, First Gunma International Symposium on Chemistry, Nov. 2004, gunma
  • Nov. 2004
  • Modified DNAzyme with aldolase activity, The First Gunma International Symposium on Chemistry, Nov. 2004, 群馬
  • Oct. 2004
  • Oct. 2004
  • Sep. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Mar. 2004
  • Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted arabinofuranosyluracils, 尾崎 広明; 中島 清尋; 矢島 杏子; 辰井 薫; 桑原 正靖; 澤井 宏明, 第3回国際核酸化学シンポジウム, Sep. 2003, 北海道
  • Mar. 2003
  • Mar. 2003
  • Mar. 2003
  • Nov. 2002
  • Synthesis of modified DNAs bearing two different fluorescent probes and its application to fluorescence resonance energy transfer, Hiroaki Ozaki; Hiroshi Kobari; Kazuki Takagi; Hiroaki Sawai, 15th International round table on Nucleosides, Nucleotides and Nucleic Acids,, Sep. 2002, Leuven, Belgium
  • Mar. 2002
  • Mar. 2002
  • Mar. 2002
  • Fluorescence properties of C5-heteroaryl-pyrimidine nucleosides and post-synthetic modification of DNA, Miu Hara, Keita Kudo, Kie Sakurai, Wakaba Yoshizawa, Hiroaki Ozaki, The 104th CSJ Annual Meeting (2024), 19 Mar. 2024, Funabashi, Chiba, Japan
  • 03 Dec. 2022, Japanese, Japan
  • 5-(4メトキシフェニル)-2´-デオキシウリジン含有DNAの合成と蛍光特性, 05 Dec. 2020, Japanese

■Information on Social Contribution Activities

Social Activities

  • 09 Aug. 2020, 09 Aug. 2020, Qualification seminar, Yes