Life sciences, Radiology

Space biology

Hyperthermic biology

Radiation biology

Elucidation of molecular mechanisms for radiation-induced cellular responses, Radiation,　DNA damage, repair, cell death, Personal, 2011, 2015, Radiation Science, JST Target Oriented Research for Embryonic Science and Technology (TOREST)

Biological effect of space radiation, Domestic Collaboration, 2015, -, Radiation/Chemical Substance Influence Science, Grant-in-Aid for Scientific Research

Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice, Kenshi Suzuki, Chizuru Tsuruoka, Takamitsu Morioka, Hitomi Seo, Mari Ogawa, Ryosuke Kambe, Tatsuhiko Imaoka, Shizuko Kakinuma, Akihisa Takahashi, No, Yes, No, Mar. 2024, Life Sci Space Res (Amst), 41, 202, 209, Scientific journal

Synthetic torpor protects rats from exposure to accelerated heavy ions, Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, Palma Simoniello, Marco Durante, Walter Tinganelli, No, No, No, 30 Sep. 2022, Sci Rep ., 12, 1, 16405, Scientific journal

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Zhenlin Ju, Tamlyn N. Thomas, Yi-Jen Chiu, Sakuya Yamanouchi, Yukari Yoshida, Jun-ichi Abe, Akihisa Takahashi, Jing Wang, Keigi Fujiwara, Megumi Hada, No, No, No, 30 May 2022, Int J Mol Sci, 23, 11, 6127, Scientific journal

Th balance related host genetic background affects the therapeutic effects of combining carbon-ion radiotherapy with dendritic cell immunotherapy, Liqiu Ma, Yoshimitsu Sakamoto, Ken Ando, Hidetoshi Fujita, Akihisa Takahashi, Tsuguhide Takeshima, Hiromi Otsuka, Daniel K Ebner, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa, No, No, No, 03 Nov. 2021, Int J Radiat Oncol Biol Phys, 112, 3, 780, 789, Scientific journal

The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Sakuya Yamanouchi;Takuya Adachi;Yukari Yoshida;Jordan Rhone;Jian-Hua Mao;Keigi Fujiwara;Premkumar B. Saganti;Akihisa Takahashi;Megumi Hada, No, No, Yes, Jul. 2021, Biological Sciences in Space, Scientific journal

Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with a partial gravity environment, Shenke Zhang, Daishin Ueno, Takashi Ohira, Hisashi Kato, Tetsuya Izawa, Sakuya Yamanouchi, Yukari Yoshida, Akihisa Takahashi, Yoshinobu Ohira, No, No, Yes, Jun. 2021, Frontiers in Cell and Development Biology, Scientific journal

Combined-environment simulator for low-dose-rate radiation and partial gravity of Moon and Mars, Akihisa Takahashi; Sakuya Yamanouchi; Kazuomi Takeuchi; Shogo Takahashi; Mutsumi Tashiro; Jun Hidema; Atsushi Higashitani; Takuya Adachi; Shenke Zhang; Fady Nagy Lotfy Guirguis; Yukari Yoshida; Aiko Nagamatsu; Megumi Hada; Kunihito Takeuchi; Tohru Takahashi; Yuji Sekitomi, No, Yes, Nov. 2020, Life, 10, 11, 274, 274, Scientific journal

Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations, Yamanouchi Sakuya;Rhone Jordan;Mao Jian-Hua;Fujiwara Keigi;Saganti Premkumar B;Takahashi Akihisa;Hada Megumi, No, No, Yes, 10 Sep. 2020, Life (Basel), 10, 9, 187, 187

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways., Ito Soichiro S;Nakagawa Yosuke;Matsubayashi Masaya;Sakaguchi Yoshihiko M;Kobashigawa Shinko;Matsui Takeshi K;Nanaura Hitoki;Nakanishi Mari;Kitayoshi Fumika;Kikuchi Sotaro;Kajihara Atsuhisa;Tamaki Shigehiro;Sugie Kazuma;Kashino Genro;Takahashi Akihisa;Hasegawa Masatoshi;Mori Eiichiro;Kirita Tadaaki, No, No, No, 16 Jul. 2020, The Journal of Biological Chemistry, 295, 37, 12946, 12961

Correction: Oh, J.Y., et al. Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells, Cancers 2019, 11, 1812., Oh Ju Yeon;Kim Eun Ho;Lee Yeon-Joo;Sai Sei;Lim Sun Ha;Park Jang Woo;Chung Hye Kyung;Kim Joon;Vares Guillaume;Takahashi Akihisa;Jeong Youn Kyoung;Kim Mi-Sook;Kong Chang-Bae, 26 May 2020, Cancers (Basel), 12, 6

Characterization of a novel murine colon carcinoma subline with high-metastatic activity established by in vivo selection method., Liqiu Ma; Yoshimitsu Sakamoto; Akinori Kanai; Hiromi Otsuka; Akihisa Takahashi; Kazuhiro Kakimi; Takashi Imai; Takashi Shimokawa, No, No, 18 Apr. 2020, International Kournal of Molecular Sciences, 21, 8, 2829, Scientific journal

Carbon-ion beam irradiation alone or in combination with zoledronic acid effectively kills osteosarcoma cells, Kim Eun Ho;Kim Mi-Sook;Takahashi Akihisa;Suzuki Masao;Vares Guillaume;Uzawa Akiko;Fujimori Akira;Ohno Tatsuya;Sai Sei, No, No, No, 16 Mar. 2020, Cancers (Basel), 12, 3, 698, 698, Scientific journal

Synergistic autophagy effect of miR-212-3p in zoledronic acid-treated in vitro and orthotopic in vvo models and in patient-derived osteosarcoma cells, Oh Ju Yeon;Kim Eun Ho;Lee Yeon-Joo;Sai Sei;Lim Sun Ha;Park Jang Woo;Chung Hye Kyung;Kim Joon;Vares Guillaume;Takahashi Akihisa;Jeong Youn Kyoung;Kim Mi-Sook;Kong Chang-Bae, No, No, No, 18 Nov. 2019, Cancers (Basel), 11, 11, 1812, 1812, Scientific journal

Anti-metastatic benefits produced by hyperthermia and a CCL3 derivative, Ma Liqiu;Kambe Ryosuke;Tsuchiya Tomoko;Kanegasaki Shiro;Takahashi Akihisa, No, Yes, Yes, 11 Nov. 2019, Cancers (Basel), 11, 11, 1770, 1770, Scientific journal

X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity., Puspitasari Anggraeini;Yamazaki Hiroyuki;Kawamura Hidemasa;Nakano Takashi;Takahashi Akihisa;Shirao Tomoaki;Held Kathryn D, No, No, No, 08 Nov. 2019, Neuroscience Research, 160, 11, 24, Scientific journal

Yes, No, Yes, Oct. 2019, 68, 10, 701, Scientific journal

No, Yes, No, Oct. 2019, 68, 10, 723, Scientific journal

Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Ikeda Hiroko;Muratani Masafumi;Hidema Jun;Hada Megumi;Fujiwara Keigi;Souda Hikaru;Yoshida Yukari;Takahashi Akihisa, No, Yes, Yes, 26 Sep. 2019, International Journal of Molecular Sciences, 20, 19, 4791, 4791, Scientific journal

Melatonin is a potential drug for the prevention of bone loss during space flight., Ikegame Mika;Hattori Atsuhiko;Tabata Makoto J;Kitamura Kei-Ichiro;Tabuchi Yoshiaki;Furusawa Yukihiro;Maruyama Yusuke;Yamamoto Tatsuki;Sekiguchi Toshio;Matsuoka Risa;Hanmoto Taizo;Ikari Takahiro;Endo Masato;Omori Katsunori;Nakano Masaki;Yashima Sayaka;Ejiri Sadakazu;Taya Toshiki;Nakashima Hiroshi;Shimizu Nobuaki;Nakamura Masahisa;Kondo Takashi;Hayakawa Kazuichi;Takasaki Ichiro;Kaminishi Atsushi;Akatsuka Ryosuke;Sasayama Yuichi;Nishiuchi Takumi;Nara Masayuki;Iseki Hachiro;Chowdhury Vishwajit S;Wada Shigehito;Ijiri Kenichi;Takeuchi Toshio;Suzuki Tohru;Ando Hironori;Matsuda Kouhei;Somei Masanori;Mishima Hiroyuki;Mikuni-Takagaki Yuko;Funahashi Hisayuki;Takahashi Akihisa;Watanabe Yoshinari;Maeda Masahiro;Uchida Hideaki;Hayashi Akio;Kambegawa Akira;Seki Azusa;Yano Sachiko;Shimazu Toru;Suzuki Hiromi;Hirayama Jun;Suzuki Nobuo, 19 Jul. 2019, Journal of pineal research, 67, 3

Effects of p53 Status of Tumor Cells and Combined Treatment With Mild Hyperthermia, Wortmannin or Caffeine on Recovery From Radiation-Induced Damage., Masunaga Shin-Ichiro;Tano Keizo;Sanada Yu;Suzuki Minoru;Takahashi Akihisa;Ohnishi Ken;Ono Koji, 29 Jun. 2019, World journal of oncology, 10, 3

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Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation., Hada Megumi;Ikeda Hiroko;Rhone Jordan R;Beitman Andrew J;Plante Ianik;Souda Hikaru;Yoshida Yukari;Held Kathryn D;Fujiwara Keigi;Saganti Premkumar B;Takahashi Akihisa, 22 Dec. 2018, International journal of molecular sciences, 20, 1

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice., Takahashi Akihisa;Wakihata Shoto;Ma Liqiu;Adachi Takuya;Hirose Hiroki;Yoshida Yukari;Ohira Yoshinobu, 09 Dec. 2018, International journal of molecular sciences, 19, 12

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Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks., Takahashi Akihisa;Ikeda Hiroko;Yoshida Yukari, 21 Sep. 2018, International journal of particle therapy, 5, 1

Heat induces histone γH2AX gormation under hypoxia, Yoshida Y; Tominaga S; Ma L; Takahashi A, Sep. 2018, Thermal Medicine, 34, 3, 45, 51, Scientific journal

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X-ray irradiation induces disruption of the blood-brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain., Yoshida Yukari;Sejimo Yukihiko;Kurachi Masashi;Ishizaki Yasuki;Nakano Takashi;Takahashi Akihisa, 12 Mar. 2018, Neurochemistry international, 119

Performance evaluation of new devices to synchronize heavy-ion or X-ray irradiation and simulated microgravity for space radiation research ~ Improvement of a control stage ~., Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T, 2018, The 31st International Symposium on Space Technology and Science (ISTS), proceeding (Theses ID: 2017-p-09), International conference proceedings

Heavy-ion irradiation overcomes Lin28B-induced X-ray resistance in melanoma cells, Takahashi, Akihisa;Yoshida, Yukari;Ohno, Tatsuya;Nakano, Takashi, 2018, CANCER SCIENCE, 109, 750, 750

Establishment and characterization of a novel highly metastatic colon carcinoma clone, Colon-26MGS, Ma, Liqiu;Takahashi, Akihisa;Imai, Takashi;Shimokawa, Takashi, 2018, CANCER SCIENCE, 109, 874, 874

Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells, Seong-Joon Park; Kyu Heo; Chulwon Choi; Kwangmo Yang; Akiko Adachi; Hiroko Okada; Yukari Yoshida; Tatsuya Ohno; Takashi Nakano; Akihisa Takahashi, Nov. 2017, Journal of Radiation Research, 58, 6, 765, 771, Scientific journal

BRCA2 protects mammalian cells from heat shock., Nakagawa Yosuke;Kajihara Atsuhisa;Takahashi Akihisa;Murata Akiho S;Matsubayashi Masaya;Ito Soichiro S;Ota Ichiro;Nakagawa Takahiko;Hasegawa Masatoshi;Kirita Tadaaki;Ohnishi Takeo;Mori Eiichiro, 10 Sep. 2017, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 34, 6

Takeo Ohnishi, PhD, 1944-2017., Takahashi Akihisa;Mori Eiichiro;Ohnishi Ken;Matsumoto Hideki, 02 Aug. 2017, Radiation research, 188, 4

Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells, Akihisa Takahashi; Eiichiro Mori; Yosuke Nakagawa; Atsuhisa Kajihara; Tadaaki Kirita; Douglas L. Pittman; Masatoshi Hasegawa; Takeo Ohnishi, May 2017, International Journal of Hyperthermia, 33, 3, 336, 342, Scientific journal

Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system., Ikeda Hiroko;Souda Hikaru;Puspitasari Anggraeini;Held Kathryn D;Hidema Jun;Nikawa Takeshi;Yoshida Yukari;Kanai Tatsuaki;Takahashi Akihisa, 23 Jan. 2017, Life sciences in space research, 12

Future Scenario of the Space Radiation Research Using Space Environment, TAKAHASHI Akihisa;HIDEMA Jun;YASUDA Hiroshi, 2017, International journal of microgravity science and application, 34, 2

A new system for three-dimensional clinostat synchronized X-irradiation with a high-speed shutter for space radiation research, Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T; Takahashi A, Dec. 2016, Biological Science in Space, 30, 0, 8, 16, Scientific journal

Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells., Takahashi Akihisa;Mori Eiichiro;Nakagawa Yosuke;Kajihara Atsuhisa;Kirita Tadaaki;Pittman Douglas L;Hasegawa Masatoshi;Ohnishi Takeo, 13 Nov. 2016, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 33, 3

Effects of Charged Particles on Human Tumor Cells., Held Kathryn D;Kawamura Hidemasa;Kaminuma Takuya;Paz Athena Evalour S;Yoshida Yukari;Liu Qi;Willers Henning;Takahashi Akihisa, 12 Feb. 2016, Frontiers in oncology, 6

A New System for Three-dimensional Clinostat Synchronized X-irradiation with a High-speed Shutter for Space Radiation Research, Ikeda Hiroko;Souda Hikaru;Puspitasari Anggraeini;Held Kathryn D.;Hidema Jun;Nikawa Takeshi;Yoshida Yukari;Kanai Tatsuaki;Takahashi Akihisa, 2016, Biological Sciences in Space, 30, 0, 8, 16

Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775., Ma Hongyu;Takahashi Akihisa;Sejimo Yukihiko;Adachi Akiko;Kubo Nobuteru;Isono Mayu;Yoshida Yukari;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 08 Dec. 2015, Radiation research, 184, 6

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells., Ma Hongyu;Takahashi Akihisa;Yoshida Yukari;Adachi Akiko;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 09 Nov. 2015, Radiation oncology (London, England), 10

Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells., Isono Mayu;Yoshida Yukari;Takahashi Akihisa;Oike Takahiro;Shibata Atsushi;Kubota Yoshiki;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 11 Jun. 2015, Journal of radiation research, 56, 5

Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460., Kubo Nobuteru;Noda Shin-ei;Takahashi Akihisa;Yoshida Yukari;Oike Takahiro;Murata Kazutoshi;Musha Atsushi;Suzuki Yoshiyuki;Ohno Tatsuya;Takahashi Takeo;Nakano Takashi, 18 Jan. 2015, Journal of radiation research, 56, 2

Targeting of Carbon Ion-Induced G(2) Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775, Ma, Hongyu;Takahashi, Akihisa;Sejimo, Yukihiko;Adachi, Akiko;Kubo, Nobuteru;Isono, Mayu;Yoshida, Yukari;Kanai, Tatsuaki;Ohno, Tatsuya;Nakano, Takashi, 2015, RADIATION RESEARCH, 184, 6, 660, 669

3　Particle Beam Therapy for Cancer:A Radiobiological Perspective, TAKAHASHI Akihisa;YOSHIDA Yukari, 2015, RADIOISOTOPES, 64, 6, 377, 381

Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation., Takahashi Akihisa;Kubo Makoto;Ma Hongyu;Nakagawa Akiko;Yoshida Yukari;Isono Mayu;Kanai Tatsuaki;Ohno Tatsuya;Furusawa Yoshiya;Funayama Tomoo;Kobayashi Yasuhiko;Nakano Takashi, 12 Aug. 2014, Radiation research, 182, 3

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells., Murata Kazutoshi;Noda Shin-ei;Oike Takahiro;Takahashi Akihisa;Yoshida Yukari;Suzuki Yoshiyuki;Ohno Tatsuya;Funayama Tomoo;Kobayashi Yasuhiko;Takahashi Takeo;Nakano Takashi, 21 Mar. 2014, Journal of radiation research, 55, 4

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells., Nakagawa Yosuke;Kajihara Atsuhisa;Takahashi Akihisa;Kondo Natsuko;Mori Eiichiro;Kirita Tadaaki;Ohnishi Takeo, 11 Mar. 2014, Oncology reports, 31, 5

Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells., Takahashi A; Ma H; Nakagawa A; Yoshida Y; Kanai T; Ohno T; Kuwahara Y; Fukumoto M; Nakano T, 2014, Int J Med Phys Clin Engin Radiat Oncol., 3, 133, 142

Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation, Takahashi, Akihisa;Kubo, Makoto;Ma, Hongyu;Nakagawa, Akiko;Yoshida, Yukari;Isono, Mayu;Kanai, Tatsuaki;Ohno, Tatsuya;Furusawa, Yoshiya;Funayama, Tomoo;Kobayashi, Yasuhiko;Nakano, Takashi, 2014, RADIATION RESEARCH, 182, 3, 338, 344

Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation, Yosuke Nakagawa; Akihisa Takahashi; Atsuhisa Kajihara; Nobuhiro Yamakawa; Yuichiro Imai; Ichiro Ota; Noritomo Okamoto; Eiichiro Mori; Taichi Noda; Yoshiya Furusawa; Tadaaki Kirita; Takeo Ohnishi, Jul. 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423, 4, 654, 660, Scientific journal

Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells, T. Shimura; N. Noma; T. Oikawa; Y. Ochiai; S. Kakuda; Y. Kuwahara; Y. Takai; A. Takahashi; M. Fukumoto, Jun. 2012, ONCOGENESIS, 1, e12, Scientific journal

The combination of olaparib and camptothecin for effective radiosensitization, Katsutoshi Miura; Koh-ichi Sakata; Masanori Someya; Yoshihisa Matsumoto; Hideki Matsumoto; Akihisa Takahashi; Masato Hareyama, Apr. 2012, RADIATION ONCOLOGY, 7, 62, Scientific journal

Expression of p53-regulated proteins in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight., Takahashi Akihisa;Suzuki Hiromi;Omori Katsunori;Seki Masaya;Hashizume Toko;Shimazu Toru;Ishioka Noriaki;Ohnishi Takeo, 25 Feb. 2012, Journal of radiation research, 53, 2

Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells, F. Yatagai; M. Honma; A. Ukai; K. Omori; H. Suzuki; T. Shimazu; A. Takahashi; T. Ohnishi; N. Dohmae; N. Ishioka, Feb. 2012, ADVANCES IN SPACE RESEARCH, 49, 3, 479, 486, Scientific journal

Therapeutic strategies for head and neck cancer based on p53 status (Review), Ota, Ichiro;Okamoto, Noritomo;Yane, Katsunari;Takahashi, Akihisa;Masui, Takashi;Hosoi, Hiroshi;Ohnishi, Takeo, 2012, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 3, 4, 585, 591

Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight, TAKAHASHI Akihisa;SUZUKI Hiromi;OMORI Katsunori;SEKI Masaya;HASHIZUME Toko;SHIMAZU Toru;ISHIOKA Noriaki;OHNISHI Takeo, 2012, Journal of Radiation Research, 53, 2, 168, 175

Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G_2/M Phase-dependent, SU Xiaoming;TAKAHASHI Akihisa;KONDO Natsuko;NAKAGAWA Yosuke;IWASAKI Toshiyasu;GUO Guozhen;OHNISHI Takeo, Sep. 2011, 52, 5, 609, 615

FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Minoru Suzuki; Yuko Kinashi; Shinichiro Masunaga; Koji Ono; Masatoshi Hasegawa; Takeo Ohnishi, May 2011, PLOS ONE, 6, 5, e19659, Scientific journal

Toward Future Space Experiments for Life Sciences, HOSON Takayuki;TAKAHASHI Akihisa;NIKAWA Takeshi;FUKUI Keiji;OGAWA Shiho;HIGASHITANI Atsushi, Apr. 2011, Biological sciences in space, 25, 1, 21, 24

Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation, Fumio Yatagai; Masamitsu Honma; Akihisa Takahashi; Katsunori Omori; Hiromi Suzuki; Toru Shimazu; Masaya Seki; Toko Hashizume; Akiko Ukai; Kaoru Sugasawa; Tomoko Abe; Naoshi Dohmae; Shuichi Enomoto; Takeo Ohnishi; Alasdair Gordon; Noriaki Ishioka, Mar. 2011, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 50, 1, 125, 134, Scientific journal

Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state, A. Takahashi; H. Suzuki; K. Omori; M. Seki; T. Hashizume; T. Shimazu; N. Ishioka; T. Ohnishi, Mar. 2011, ADVANCES IN SPACE RESEARCH, 47, 6, 1062, 1070, Scientific journal

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage, Taichi Noda; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Noritomo Okamoto; Yosuke Nakagawa; Ken Ohnishi; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Hideo Asada; Takeo Ohnishi, Jan. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 1, 206, 210, Scientific journal

siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells, Noritomo Okamoto; Akihisa Takahashi; Ichiro Ota; Ken Ohnishi; Eiichiro Mori; Natsuko Kondo; Taichi Noda; Yosuke Nakagawa; Hirokazu Uemura; Katunari Yane; Hiroshi Hosoi; Takeo Ohnishi, 2011, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 27, 3, 297, 304, Scientific journal

Ultrasound-induced DNA damage and signal transductions indicated by gammaH2AX, Yukihiro Furusawa; Yoshisada Fujiwara; Qing-Li Zhao; Mariame Ali Hassan; Ryohei Ogawa; Yoshiaki Tabuchi; Ichiro Takasaki; Akihisa Takahashi; Takeo Ohnishi; Takashi Kondo, 2011, 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010), 1359, 322, +, International conference proceedings

Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G2/M Phase-dependent, SU Xiaoming;TAKAHASHI Akihisa;KONDO Natsuko;NAKAGAWA Yosuke;IWASAKI Toshiyasu;GUO Guozhen;OHNISHI Takeo, 2011, Journal of Radiation Research, 52, 5, 609, 615

p53-DEPENDENT ADAPTIVE RESPONSES IN HUMAN CELLS EXPOSED TO SPACE RADIATIONS, Akihisa Takahashi; Xiaoming Su; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Toshiyasu Iwasaki; Takeo Ohnishi, Nov. 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 4, 1171, 1176, Scientific journal

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status, Yoko Nagata; Akihisa Takahashi; Ken Ohnishi; Ichiro Ota; Takeo Ohnishi; Takashi Tojo; Shigeki Taniguchi, Oct. 2010, INTERNATIONAL JOURNAL OF ONCOLOGY, 37, 4, 1001, 1010, Scientific journal

DNA ligase IV is a potential molecular target in ACNU sensitivity, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Xiaoming Su; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Koji Ono; Takeo Ohnishi, Aug. 2010, CANCER SCIENCE, 101, 8, 1881, 1885, Scientific journal

Gimeracil sensitizes cells to radiation via inhibition of homologous recombination, Masaru Takagi; Koh-ichi Sakata; Masanori Someya; Hiroshi Tauchi; Kenta Iijima; Yoshihisa Matsumoto; Toshihiko Torigoe; Akari Takahashi; Masato Hareyama; Masakazu Fukushima, Aug. 2010, RADIOTHERAPY AND ONCOLOGY, 96, 2, 259, 266, Scientific journal

The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight, Akihisa Takahashi; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Takeo Ohnishi, Aug. 2010, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 86, 8, 669, 681, Scientific journal

Recent Advances in the Biology of Heavy-Ion Cancer Therapy, Nobuyuki Hamada; Tatsuhiko Imaoka; Shin-ichiro Masunaga; Toshiyuki Ogata; Ryuichi Okayasu; Akihisa Takahashi; Takamitsu A. Kato; Yasuhiko Kobayashi; Takeo Ohnishi; Koji Ono; Yoshiya Shimada; Teruki Teshima, Jul. 2010, JOURNAL OF RADIATION RESEARCH, 51, 4, 365, 383, Scientific journal

ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating, Akihisa Takahashi; Eiichiro Mori; Xiaoming Su; Yosuke Nakagawa; Noritomo Okamoto; Hirokazu Uemura; Natsuko Kondo; Taichi Noda; Atsushi Toki; Yosuke Ejima; David J. Chen; Ken Ohnishi; Takeo Ohnishi, Jul. 2010, JOURNAL OF RADIATION RESEARCH, 51, 4, 417, 422, Scientific journal

BIPHASIC EFFECTS OF NITRIC OXIDE RADICALS ON RADIATION-INDUCED LETHALITY AND CHROMOSOME ABERRATIONS IN HUMAN LUNG CANCER CELLS CARRYING DIFFERENT p53 GENE STATUS, Xiaoming Su; Akhisa Takahashi; Guozhen Guo; Eiichiro Mori; Noritomo Okamoto; Ken Ohnishi; Toshiyasu Iwasaki; Takeo Ohnishi, Jun. 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 2, 559, 565, Scientific journal

The Foci of DNA Double Strand Break-recognition Proteins Localize with gamma H2AX after Heat Treatment, Akihisa Takahashi; Eiichiro Mori; Takeo Ohnishi, Jan. 2010, JOURNAL OF RADIATION RESEARCH, 51, 1, 91, 95, Scientific journal

Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status, Shin-ichiro Masunaga; Keizo Tano; Jun Nakamura; Masami Watanabe; Genro Kashino; Akihisa Takahashi; Hiroki Tanaka; Minoru Suzuki; Ken Ohnishi; Yuko Kinashi; Yong Liu; Takeo Ohnishi; Koji Ono, Jan. 2010, JOURNAL OF RADIATION RESEARCH, 51, 1, 27, 35, Scientific journal

DNA damage induced by alkylating agents and repair pathways, Natsuko Kondo; Akihisa Takahashi; Koji Ono; Takeo Ohnishi, 2010, Journal of Nucleic Acids, 2010, 543531

Detection of space radiation-induced double strand breaks as a track in cell nucleus, Takeo Ohnishi; Akihisa Takahashi; Aiko Nagamatsu; Katsunori Omori; Hiromi Suzuki; Toru Shimazu; Noriaki Ishioka, Dec. 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 390, 3, 485, 488, Scientific journal

DNA double-strand breaks: Their production, recognition, and repair in eukaryotes, Takeo Ohnishi; Eiichiro Mori; Akihisa Takahashi, Oct. 2009, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 669, 1-2, 8, 12

DNA ligase IV as a new molecular target for temozolomide, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Takeo Ohnishi, Oct. 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 387, 4, 656, 660, Scientific journal

A low dose: pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning, A. Takahashi; T. Ohnishi, Apr. 2009, ADVANCES IN SPACE RESEARCH, 43, 8, 1185, 1192, Scientific journal

High LET Heavy Ion Radiation Induces p53-Independent Apoptosis, Eiichiro Mori; Akihisa Takahashi; Nobuhiro Yamakawa; Tadaaki Kirita; Takeo Ohnishi, Jan. 2009, JOURNAL OF RADIATION RESEARCH, 50, 1, 37, 42

Alkylating agents-induced DNA damage- Repair Mechanisms and Application for Cancer Therapy, N. Kondo; A. Takahashi; T. Ohnishi, 2009, Radiat. Biol. Res. Commun, 44, 140, 153

Computational image processing and analysis of heat-induced γH2AX foci., Somakos GI; Takahashi A; Mori E; Ohnishi T, 2009, Thermal Med., 25, 25, 34

A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status., Takahashi A; Ohnishi T, 2009, Thermal Med., 25, 13, 23

Restraint plus water-immersion stress (RWIS)-induced stomach ulcers in mice are depressed by a conditioning heat treatment., Yamagata R; Takahashi A; Su X; Morimoto T; Ohnishi T, 2009, Thermal Med., 25, 81, 87

Chemotherapy combined with hyperthermia improves the prognosis for non-small-cell lung cancer., Toki A; Takahashi A; Tachibana S, 2009, Thermal Med., 25, 4, 115, 122

DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus, Aklhlsa Takahashi; Nobuhiro Yamakawa; Tadaaki Kirita; Katsunori Omori; Noriaki Ishioka; Yoshiya Furusawa; Eiichiro Mori; Ken Ohnishi; Takeo Ohnishi, Nov. 2008, JOURNAL OF RADIATION RESEARCH, 49, 6, 645, 652, Scientific journal

Heat induces gammaH2AX foci formation in mammalian cells., Takahashi A; Mori E; Somakos GI; Ohnishi K; Ohnishi T, Oct. 2008, Mutation research, 656, 1-2, 88, 92

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation, Nobuhiro Yamakawa; Akihisa Takahashi; Eiichiro Mori; Yuichiro Imai; Yoshiya Furusawa; Ken Ohnishi; Tadaaki Kirita; Takeo Ohnishi, Jul. 2008, CANCER SCIENCE, 99, 7, 1455, 1460, Scientific journal

Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP, Ken Ohnishi; Yoko Nagata; Akihisa Takahashi; Shigeki Taniguchi; Takeo Ohnishi, Jul. 2008, ONCOLOGY REPORTS, 20, 1, 57, 61, Scientific journal

Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response, Akihisa Takahashi; Hideki Matsumoto; Takeo Ohnishi, Jun. 2008, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 71, 2, 550, 558, Scientific journal

Time course and spacial distribution of UV effects on human skin in organ culture, Eiichiro Mori; Akihisa Takahashi; Kou Kitagawa; Saki Kakei; Daiki Tsujinaka; Megumi Unno; Shoko Nishikawa; Ken Ohnishi; Mitsuo Hatoko; Norio Murata; Masakatsu Watanabe; Yoshiya Furusawa; Takeo Ohnishi, May 2008, JOURNAL OF RADIATION RESEARCH, 49, 3, 269, 277, Scientific journal

Development of thermotolerance requires interaction between polymerase-beta and heat shock proteins, Akihisa Takahashi; Nobuhiro Yamakawa; Eiichiro Mori; Ken Ohnishi; Shin-ichi Yokota; Noriyuki Sugo; Yasuaki Aratani; Hideki Koyama; Takeo Ohnishi, May 2008, CANCER SCIENCE, 99, 5, 973, 978, Scientific journal

Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes, Atsuhisa Kajihara; Akihisa Takahashi; Ken Ohnishi; Yuichiro Imai; Nobuhiro Yamakawa; Jun-ichi Yasumoto; Takeo Ohnishi; Tadaaki Kirita, 2008, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 24, 8, 605, 612, Scientific journal

Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population, Shin-ichiro Masunaga; Akihisa Takahashi; Ken Ohnishi; Kenji Nagata; Minoru Suzuki; Genro Kashino; Yuko Kinashi; Takeo Ohnishi; Koji Ono, Dec. 2007, ONCOLOGY REPORTS, 18, 6, 1589, 1596, Scientific journal

Nitric oxide radicals choreograph a radioadaptive response, Hideki Matsumoto; Akihisa Takahashi; Takeo Ohnishi, Sep. 2007, CANCER RESEARCH, 67, 18, 8574, 8579, Scientific journal

Vanguards of Paradigm Shift in Radiation Biology : Radiation-Induced Adaptive and Bystander Responses, MATSUMOTO Hideki;HAMADA Nobuyuki;TAKAHASHI Akihisa;KOBAYASHI Yasuhiko;OHNISHI Takeo, Mar. 2007, Journal of Radiation Research, 48, 2, 97, 106

Heat-induced phosphorylation of NBS1 in human skin fibroblast cells, Ken Ohnishi; Zorica Scuric; David Yau; Robert H. Schiestl; Noritomo Okamoto; Akihisa Takahashi; Takeo Ohnishi, Dec. 2006, JOURNAL OF CELLULAR BIOCHEMISTRY, 99, 6, 1642, 1650, Scientific journal

siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status, Ken Ohnishi; Zorica Scuric; Robert H. Schiestl; Noritomo Okamoto; Akihisa Takahashi; Takeo Ohnishi, Sep. 2006, RADIATION RESEARCH, 166, 3, 454, 462, Scientific journal

Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells, Ken Ohnishi; Shinichi Yokota; Akihisa Takahashi; Takeo Ohnishi, Aug. 2006, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 82, 8, 569, 575, Scientific journal

LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells, Ken Ohnishi; Jun-Ichi Yasumoto; Akihisa Takahashi; Takeo Ohnishi, Jul. 2006, INTERNATIONAL JOURNAL OF ONCOLOGY, 29, 1, 249, 253, Scientific journal

UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis, A Takahashi; N Shibata; S Nishikawa; K Ohnishi; N Ishioka; T Ohnishi, 2006, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 5, 5, 467, 471, Scientific journal

Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status, A Takahashi; H Matsumoto; Y Furusawa; K Ohnishi; N Ishioka; T Ohnishi, Aug. 2005, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 81, 8, 581, 586, Scientific journal

Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells, SI Masunaga; H Nagasawa; Y Uto; H Hori; K Ohnishi; A Takahashi; T Ohnishi; M Suzuki; K Nagata; Y Kinashi; K Ono, Aug. 2005, ONCOLOGY REPORTS, 14, 2, 393, 400, Scientific journal

Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis, Y Imai; K Ohnishi; J Yasumoto; A Kajiwara; N Yamakawa; A Takahashi; T Ohnishi; T Kirita, Jul. 2005, ORAL ONCOLOGY, 41, 6, 631, 636, Scientific journal

Reactivation in Paramecium tetraurelia under conditions of various degrees of ozone layer depletion, A Takahashi; T Kumatani; S Usui; R Tsujimura; T Seki; K Morimoto; T Ohnishi, Jul. 2005, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 81, 4, 1010, 1014, Scientific journal

Evidence for the involvement of double-strand breaks in heat-induced cell killing, A Takahashi; H Matsumoto; K Nagayama; M Kitano; S Hirose; H Tanaka; E Mori; N Yamakawa; J Yasumoto; K Yuki; K Ohnishi; T Ohnishi, Dec. 2004, CANCER RESEARCH, 64, 24, 8839, 8845, Scientific journal

Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene, K Yuki; A Takahashi; Ota, I; K Ohnishi; J Yasumoto; K Yane; H Kanata; N Okamoto; H Hosoi; T Ohnishi, Nov. 2004, APOPTOSIS, 9, 6, 853, 859, Scientific journal

High-let radiation enhanced apoptosis but not necrosis regardless of P53 status, A Takahashi; H Matsumoto; K Yuki; JI Yasumoto; A Kajiwara; M Aoki; Y Furusawa; K Ohnishi; T Ohnishi, Oct. 2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 2, 591, 597, Scientific journal

Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations, SI Masunaga; A Takahashi; K Ohnishi; T Ohnishi; K Nagata; M Suzuki; Y Kinashi; K Ono, Oct. 2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 2, 570, 577, Scientific journal

C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells, K Ohnishi; H Inaba; J Yasumoto; K Yuki; A Takahashi; T Ohnishi, Sep. 2004, APOPTOSIS, 9, 5, 591, 597, Scientific journal

Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status, K Ohnishi; A Takahashi; S Yokota; T Ohnishi, Aug. 2004, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 80, 8, 607, 614, Scientific journal

Comparative study of otolith organs between two species of upside-down swimming catfish Synodontis nigriventris showing converse swimming postures, K Ohnishi; Y Ogawa; A Takahashi; M Yamashita; T Ohnishi, Jul. 2004, ACTA ZOOLOGICA, 85, 3, 201, 209, Scientific journal

Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene, K Yuki; A Takahashi; Ota, I; K Ohnishi; JI Yasumoto; H Kanata; K Yane; H Hosoi; T Ohnishi, Apr. 2004, ONCOLOGY REPORTS, 11, 4, 821, 824, Scientific journal

Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53, J Yasumoto; T Kirita; A Takahashi; K Ohnishi; Y Imai; K Yuki; T Ohnishi, Feb. 2004, CANCER LETTERS, 204, 1, 41, 51, Scientific journal

Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation, A. Takahashi; K. Ohnishi; T. Ohnishi, 2004, International Journal of Low Radiation, 1, 2, 199, 207, Scientific journal

Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53, T Tamamoto; H Yoshimura; A Takahashi; Asakawa, I; Ota, I; H Nakagawa; K Ohnishi; H Ohishi; T Ohnishi, Nov. 2003, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 19, 6, 590, 597, Scientific journal

The effect of clinorotation on vestibular compensation in upside-down swimming catfish., Ohnishi K; Okamoto N; Yamanaka T; Takahashi A; Hosoi H; Ohnishi T, Oct. 2003, Biol Sci Space., 17, 3, 165, 166

Effects of p53 Status and Wortmannin Treatment on Potentially Lethal Damage Repair, with Emphasis on the Response of Intratumor Quiescent Cells, Shin-Ichiro Masunaga; Akihisa Takahashi; Ken Ohnishi; Takeo Ohnishi; Minoru Suzuki; Kenji Nagata; Yuko Kinashi; Koji Ono, May 2003, Radiation Medicine - Medical Imaging and Radiation Oncology, 21, 3, 120, 127, Scientific journal

Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene, J Yasumoto; Y Imai; A Takahashi; K Ohnishi; K Yuki; T Kirita; T Ohnishi, Mar. 2003, JOURNAL OF RADIATION RESEARCH, 44, 1, 41, 45, Scientific journal

Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status, S Masunaga; K Ono; A Takahashi; K Ohnishi; T Ohnishi; M Suzuki; K Nagata; Y Kinashi; H Nagasawa; Y Uto; H Hori, Jan. 2003, CANCER SCIENCE, 94, 1, 125, 133, Scientific journal

Radiation-induced apoptosis in SCID mice spleen after low dose irradiation, A Takahashi; N Kondo; H Inaba; K Uotani; Y Kiyohara; K Ohnishi; T Ohnishi, 2003, SPACE LIFE SCIENCES: BIODOSIMETRY, BIOMARKERS AND LATE STOCHASTIC EFFECTS OF SPACE RADIATION, 31, 6, 1569, 1573, Scientific journal

p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation, A Takahashi; Ota, I; T Tamamoto; Asakawa, I; Y Nagata; H Nakagawa; N Kondo; K Ohnishi; Y Furusawa; H Matsumoto; T Ohnishi, 2003, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 19, 2, 145, 153, Scientific journal

Usefulness of combined treatment with mild hyperthermia and/or tirapazamine in the treatment of solid tumors consisting of mutated p53 status cells, Masunaga S; Ono K; Takahashi A; Ohnishi K; Ohnishi T; Suzuki M; Nagata K; Kinashi Y; Nagasawa H; Uto Y; Hori H, 2003, Int J Radiat Oncol Biol Phys, 55, 485, 486

Impact of the p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cells, S Masunaga; K Ono; A Takahashi; Y Sakurai; K Ohnishi; T Kobayashi; Y Kinashi; M Takagaki; T Ohnishi, Dec. 2002, JAPANESE JOURNAL OF CANCER RESEARCH, 93, 12, 1366, 1377, Scientific journal

Detection of DNA damage induced by space radiation in Mir and space shuttle, T Ohnishi; K Ohnishi; A Takahashi; Y Taniguchi; M Sato; T Nakano; S Nagaoka, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S133, S136, Scientific journal

Mutation frequency of plasmid DNA and Escherichia coli following long-term space flight on Mir, A Takahashi; K Ohnishi; A Yokota; T Kumagai; T Nakano; T Ohnishi, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S137, S140, Scientific journal

Studies about space radiation promote new fields in radiation biology, T Ohnishi; A Takahashi; K Ohnishi, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S7, S12, Scientific journal

Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells, Ken Ohnishi; Ichiro Ota; Akihisa Takahashi; Kazue Yuki; Mie Emoto; Hiroshi Hosoi; Takeo Ohnishi, 04 Oct. 2002, Molecular Cancer, 1, 4, Scientific journal

Analysis of death pattern in cancer cells by using different kinds of LET radiation, Akihisa Takahashi; Ken Ohnishi; Mizuho Aoki; Yoshiya Furusawa; Takeo Ohnishi, Sep. 2002, Nippon Acta Radiologica, 62, 10, 531, 534, Scientific journal

Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck, K Ohnishi; Ota, I; A Takahashi; K Yane; H Matsumoto; T Ohnishi, Aug. 2002, APOPTOSIS, 7, 4, 367, 372, Scientific journal

Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation, A Takahashi; Asakawa, I; K Yuki; T Matsumoto; M Kumamoto; N Kondo; K Ohnishi; A Tachibana; T Ohnishi, Aug. 2002, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 78, 8, 689, 693, Scientific journal

Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status, Asakawa, I; H Yoshimura; A Takahashi; K Ohnishi; H Nakagawa; Ota, I; Y Furusawa; T Tamamoto; H Ohishi; T Ohnishi, Jul. 2002, ANTICANCER RESEARCH, 22, 4, 2037, 2043, Scientific journal

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53, Takeo Ohnishi; Ken Ohnishi; Akihisa Takahashi, 19 Apr. 2002, BMC Biotechnology, 2, 6, Scientific journal

Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells, S Masunaga; K Ono; A Takahashi; T Ohnishi; Y Kinashi; M Takagaki, Mar. 2002, EUROPEAN JOURNAL OF CANCER, 38, 5, 718, 727, Scientific journal

High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventris., Ohnishi K; Yamamoto T; Ogawa Y; Takahashi A; Yamashita M; Ohnishi T, Mar. 2002, Biol Sci Space., 16, 1, 18, 21

Significance of the p53 status of the tumor cells in neutron captutre therapy, S Masunaga; K Ono; A Takahashi; Y Sakurai; T Kobayashi; Y Kinashi; T Ohnishi, 2002, RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 739, 743, International conference proceedings

p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET, A Takahashi; K Ohnishi; Ota, I; Asakawa, I; T Tamamoto; Y Furusawa; H Matsumoto; T Ohnishi, Oct. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 10, 1043, 1051, Scientific journal

Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation, A Takahashi; K Ohnishi; Asakawa, I; N Kondo; H Nakagawa; M Yonezawa; A Tachibana; H Matsumoto; T Ohnishi, Sep. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 9, 939, 945, Scientific journal

Alkylating agent (MNU)-induced mutation in space environment, T. Ohnishi; A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka, Aug. 2001, Advances in Space Research, 28, 4, 563, 568, Scientific journal

The effects of microgravity on induced mutation in Escherichia coli and saccharomyces cerevisiae, A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka; T. Ohnishi, Aug. 2001, Advances in Space Research, 28, 4, 555, 561, Scientific journal

Differentation of dictyostelium discoideum vegetative cells into spores during earth orbit in space, A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka; T. Ohnishi, Aug. 2001, Advances in Space Research, 28, 4, 549, 553, Scientific journal

Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells, A Takahashi, Feb. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 2, 215, 224, Scientific journal

Tumor suppressor p53 response is blunted by low-dose-rate radiation, T Ohnishi; A Takahashi; K Ohnishi; M Yonezawa, 2001, PHYSICA MEDICA, 17, 215, 216, Scientific journal

Possible enhancement p53 gene therapy for undifferentiated thyroid carcinomas, Ota, I; K Yane; H Miyahara; M Emoto; K Ohnishii; A Takahashi; H Hosoi; T Ohnishi, 2001, BRONCHOLOGY AND BRONCHOESOPHAGOLOGY: STATE OF THE ART, 1217, 889, 891, International conference proceedings

Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53, K Ohnishi; Ota, I; A Takahashi; T Ohnishi, Dec. 2000, BRITISH JOURNAL OF CANCER, 83, 12, 1735, 1739, Scientific journal

Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir, T Fukuda; K Fukuda; A Takahashi; T Ohnishi; T Nakano; M Sato; N Gunge, Oct. 2000, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 470, 2, 125, 132, Scientific journal

CDDP induces p53-dependent apoptosis in tongue cancer cells, H Kanata; K Yane; Ota, I; H Miyahara; T Matsunaga; A Takahashi; K Ohnishi; T Ohnishi; H Hosoi, Sep. 2000, INTERNATIONAL JOURNAL OF ONCOLOGY, 17, 3, 513, 517, Scientific journal

rpsL mutation induction after space flight on MIR, F Yatagai; T Saito; A Takahashi; A Fujie; S Nagaoka; M Sato; T Ohnishi, Sep. 2000, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 453, 1, 1, 4, Scientific journal

The effects of microgravity on ligase activity in the repair of DNA double-strand breaks, A Takahashi; K Ohnishi; S Takahashi; M Masukawa; K Sekikawa; T Amano; T Nakano; S Nagaoka; T Ohnishi, Jun. 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 6, 783, 788, Scientific journal

Brief Communication: Heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from the SCID mouse, T Ohnishi; K Komatsu; H Tauchi; Wang, X; A Takahashi; K Ohnishi; A Shiba; H Matsumoto, May 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 5, 711, 715, Scientific journal

The dependence of p53 on the radiation enhancement of thermosensitivity at different LET, A Takahashi; K Ohnishi; XJ Wang; M Kobayashi; H Matsumoto; T Tamamoto; H Aoki; Y Furusawa; O Yukawa; T Ohnishi, May 2000, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 47, 2, 489, 494, Scientific journal

Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma, Ota, I; K Ohnishi; A Takahashi; K Yane; H Kanata; H Miyahara; T Ohnishi; H Hosoi, May 2000, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 47, 2, 495, 501, Scientific journal

WAF1 accumulation by carbon-ion beam and alpha-particle irradiation in human glioblastoma cultured cells, A Takahashi; K Ohnishi; K Tsuji; H Matsumoto; H Aoki; Wang, X; T Tamamoto; O Yukawa; Y Furusawa; Y Ejima; A Tachibana; T Ohnishi, Mar. 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 3, 335, 341, Scientific journal

Enzymic chemical reaction under microgravity environment in space., Ohnishi T; Takahashi A; Ohnishi K; Nakano T; Nagaoka S, 2000, J Gravit Phys., 7, 69, 70

Accumulation of tumor suppressor p53 in rat muscle after a space flight, T Ohnishi; Wang, X; S Fukuda; A Takahashi; K Ohnishi; S Nagaoka, 2000, LIFE SCIENCES: MICROGRAVITY AND SPACE RADIATION EFFECTS, 25, 10, 2119, 2122, Scientific journal

Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight, T Ohnishi; A Takahashi; XJ Wang; K Ohnishi; Y Ohira; S Nagaoka, Dec. 1999, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 430, 2, 271, 274, Scientific journal

Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells, M Fujino; K Ohnishi; M Asahi; Wang, X; A Takahashi; T Ohnishi, Oct. 1999, BRITISH JOURNAL OF DERMATOLOGY, 141, 4, 652, 657, Scientific journal

Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis, VV Ostapenko; XJ Wang; K Ohnishi; A Takahashi; Yamamoto, I; Y Tanaka; T Ohnishi, Sep. 1999, RADIATION RESEARCH, 152, 3, 321, 327, Scientific journal

Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene, T Ohnishi; H Matsumoto; Wang, X; A Takahashi; T Tamamoto; K Ohnishi, Sep. 1999, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 75, 9, 1095, 1098, Scientific journal

The effect of labyrinthectomy on postural control of upside-down swimming catfish, Synodontis nigriventris, under pseudomicrogravity, K Ohnishi; T Yamamoto; A Takahashi; H Tanaka; M Koyama; T Ohnishi, Aug. 1999, PHYSIOLOGY & BEHAVIOR, 67, 1, 89, 93, Scientific journal

The protein kinase inhibitor, H-7, suppresses heat-induced activation of heat shock transcription factor 1, K Ohnishi; Wang, X; A Takahashi; H Matsumoto; T Ohnishi, Jul. 1999, MOLECULAR AND CELLULAR BIOCHEMISTRY, 197, 1-2, 129, 135, Scientific journal

Correlation between gamma-ray-induced G(2) arrest and radioresistance in two human cancer cells, T Tamamoto; K Ohnishi; A Takahashi; XJ Wang; H Yosimura; H Ohishi; H Uchida; T Ohnishi, Jul. 1999, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 44, 4, 905, 909, Scientific journal

Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone, T Ohnishi; K Ohnishi; XJ Wang; A Takahashi; K Okaichi, Apr. 1999, RADIATION RESEARCH, 151, 4, 498, 500, Scientific journal

Detection of DNA damages and repair in human culture cells with simulated space radiation, S Nagaoka; T Nakano; S Endo; T Onizuka; Y Kagawa; K Fujitaka; K Ohnishi; A Takahashi; T Ohnishi, Apr. 1999, ACTA ASTRONAUTICA, 44, 7-12, 561, 567, Scientific journal

Low-dose-rate radiation attenuates the response of the tumor suppressor TP53, T Ohnishi; XJ Wang; A Takahashi; K Ohnishi; Y Ejima, Mar. 1999, RADIATION RESEARCH, 151, 3, 368, 372, Scientific journal

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation, XJ Wang; K Ohnishi; A Takahashi; T Ohnishi, Dec. 1998, ONCOGENE, 17, 22, 2819, 2825, Scientific journal

Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line, K Ohnishi; XJ Wang; A Takahashi; H Matsumoto; H Aoki; T Ohnishi, Apr. 1998, CELLULAR SIGNALLING, 10, 4, 259, 264, Scientific journal

Hyperthermic enhancement of tumour growth inhibition by accelerated carbon-ions in transplantable human esophageal cancer, T Ohnishi; A Takahashi; T Yano; H Matsumoto; Wang, X; K Ohnishi; T Tamamoto; K Tsuji; Y Furusawa; O Yukawa, Mar. 1998, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14, 2, 195, 202, Scientific journal

p53-independent WAF1 induction by ACNU in human glioblastoma cells, H Aoki; K Ohnishi; XJ Wang; A Takahashi; T Ohnishi; M Nakamura; T Sakaki, Mar. 1998, MOLECULAR CARCINOGENESIS, 21, 3, 171, 176, Scientific journal

p53-dependent induction of WAF1 by cold shock in human glioblastoma cells, T Ohnishi; XJ Wang; K Ohnishi; A Takahashi, Mar. 1998, ONCOGENE, 16, 11, 1507, 1511, Scientific journal

Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines, K Ohnishi; XJ Wang; A Takahashi; T Ohnishi, Feb. 1998, EXPERIMENTAL CELL RESEARCH, 238, 2, 399, 406, Scientific journal

Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice, A Takahashi; T Yano; H Matsumoto; XJ Wang; K Ohnishi; T Tamamoto; K Tsuji; O Yukawa; T Ohnishi, Jan. 1998, CANCER LETTERS, 122, 1-2, 181, 186, Scientific journal

Accumulation of stress protein 72 (HSP72) in muscle and spleen of goldfish taken into space, T. Ohnishi; K. Tsuji; T. Ohmura; H. Matsumoto; X. Wang; A. Takahahsi; S. Nagaoka; A. Takabayashi, 1998, Advances in Space Research, 21, 8-9, 1077, 1080

Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation, XJ Wang; A Takahashi; K Ohnishi; H Matsumoto; K Suda; T Ohnishi, Nov. 1997, EXPERIMENTAL CELL RESEARCH, 237, 1, 186, 191, Scientific journal

p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells, T Ohtsubo; XJ Wang; A Takahashi; K Ohnishi; H Saito; CW Song; T Ohnishi, Sep. 1997, CANCER RESEARCH, 57, 18, 3910, 3913, Scientific journal

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress, H Matsumoto; A Takahashi; XJ Wang; K Ohnishi; T Ohnishi, Jul. 1997, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 38, 5, 1089, 1095, Scientific journal

Induction of cdk2 after gamma-ray irradiation is dependent on p53 status, H Matsumoto; XJ Wang; A Takahashi; T Ohnishi, Jun. 1997, INTERNATIONAL JOURNAL OF ONCOLOGY, 10, 6, 1257, 1260, Scientific journal

Cell growth and morphology of Dictyostelium discoideum in space environment., Ohnishi T; Takahashi A; Okaichi K; Ohnishi K; Matsumoto H; Takahashi S; Yamanaka H; Nakano T; Nagaoka S, 1997, Biol Sci Space., 11, 1, 29, 34

Mutation frequency of Dictyostelium discoideum spores exposed to the space environment., Akihisa Takahashi; Ken Ohnishi; Mitsuyo Fukui; Tamotsu Nakano; Katsumi Yamaguchi; Shunji Nagaoka; Takeo Ohnishi, 1997, Biological Sciences in Space, 11, 2, 81, 86, Scientific journal

Heat shock transcription factor, HSF, is activated by ultraviolet irradiation, K Ohnishi; H Matsumoto; A Takahashi; XJ Wang; T Ohnishi, Dec. 1996, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 64, 6, 949, 952, Scientific journal

p53 accumulation in the organs of low-dose X-ray-irradiated mice, XJ Wang; H Matsumoto; A Takahashi; T Nakano; K Okaichi; M Ihara; T Ohnishi, Jun. 1996, CANCER LETTERS, 104, 1, 79, 84, Scientific journal

p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells, T Ohnishi; XJ Wang; K Ohnishi; H Matsumoto; A Takahashi, Jun. 1996, JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 24, 14510, 14513, Scientific journal

Relationship between frequency of upside-down posture and space size around upside-down catfish, Synodontis nigriventris., Ohnishi K; Takahashi A; Tanaka H; Ohnishi T, 1996, Biol Sci Space., 10, 247, 251

DNA-damaging agents induce the 72-kD heat shock protein in SV40 transformed normal human fibroblasts, Tsutomu Muramatsu; Haruhiko Ohno; Toshihiko Shirai; Akihisa Takahashi; Takeo Ohnishi, 1996, Journal of Dermatology, 23, 9, 589, 593, Scientific journal

Postural control under clinorotation in upside-down catfish, Synodontis nigriventris., Ken Ohnishil; Akihisa Takahashi; Masato Koyama; Takeo Ohnishi, 1996, Biological Sciences in Space, 10, 4, 252, 258, Scientific journal

ACCUMULATION OF MUTANT P53 AND HSP72 BY HEAT-TREATMENT, AND THEIR ASSOCIATION IN A HUMAN GLIOBLASTOMA CELL-LINE, T OHNISHI; H MATSUMOTO; A TAKAHASHI; M SHIMURA; HJ MAJIMA, Sep. 1995, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11, 5, 663, 671, Scientific journal

8-METHOXYPSORALEN PLUS UVA INDUCES THE 72 KDA HEAT-SHOCK PROTEIN IN ORGAN-CULTURED NORMAL HUMAN SKIN, T MURAMATSU; Y YAMASHINA; H TADA; N KOBAYASHI; M YAMAJI; H OHNO; T SHIRAI; A TAKAHASHI; T OHNISHI, Dec. 1993, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 58, 6, 809, 812, Scientific journal

LIGHT-INDUCED ANTHOCYANIN REDUCES THE EXTENT OF DAMAGE TO DNA IN UV-IRRADIATED CENTAUREA-CYANUS CELLS IN CULTURE, A TAKAHASHI; K TAKEDA; T OHNISHI, Jun. 1991, PLANT AND CELL PHYSIOLOGY, 32, 4, 541, 547, Scientific journal

Stable blue complexes of anthocyanin-aluminium-3-p-coumaroyl- or 3-caffeoyl-quinic acid involved in the blueing of Hydrangea flower, Kosaku Takeda; Tomoko Yamashita; Akihisa Takahashi; Colin F. Timberlake, 1990, Phytochemistry, 29, 4, 1089, 1091, Scientific journal

Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells., Park Seong-Joon;Heo Kyu;Choi Chulwon;Yang Kwangmo;Adachi Akiko;Okada Hiroko;Yoshida Yukari;Ohno Tatsuya;Nakano Takashi;Takahashi Akihisa, Journal of radiation research, 58, 6

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells, Murata, Kazutoshi;Noda, Shin-ei;Oike, Takahiro;Takahashi, Akihisa;Yoshida, Yukari;Suzuki, Yoshiyuki;Ohno, Tatsuya;Funayama, Tomoo;Kobayashi, Yasuhiko;Takahashi, Takeo;Nakano, Takashi, 2014, JOURNAL OF RADIATION RESEARCH, 55, 4, 658, 664

Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations, Yamanouchi, Sakuya;Rhone, Jordan;Mao, Jian-Hua;Fujiwara, Keigi;Saganti, Premkumar B.;Takahashi, Akihisa;Hada, Megumi, 2020, LIFE-BASEL, 10, 9

Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars, Takahashi, Akihisa;Yamanouchi, Sakuya;Takeuchi, Kazuomi;Takahashi, Shogo;Tashiro, Mutsumi;Hidema, Jun;Higashitani, Atsushi;Adachi, Takuya;Zhang, Shenke;Guirguis, Fady Nagy Lotfy;Yoshida, Yukari;Nagamatsu, Aiko;Hada, Megumi;Takeuchi, Kunihito;Takahashi, Tohru;Sekitomi, Yuji, 2020, LIFE-BASEL, 10, 11

X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity, Puspitasari, Anggraeini;Yamazaki, Hiroyuki;Kawamura, Hidemasa;Nakano, Takashi;Takahashi, Akihisa;Shirao, Tomoaki;Held, Kathryn D., 2020, NEUROSCIENCE RESEARCH, 160, 11, 24

Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b, Kim, Eun Ho;Kim, Jeong Yub;Kim, Mi-Sook;Vares, Guillaume;Ohno, Tatsuya;Takahashi, Akihisa;Uzawa, Akiko;Seo, Seung-Jun;Sai, Sei, 2020, AMERICAN JOURNAL OF CANCER RESEARCH, 10, 12, 4357, 4371

Hibernation as a Tool for Radiation Protection in Space Exploration, Puspitasari, Anggraeini;Cerri, Matteo;Takahashi, Akihisa;Yoshida, Yukari;Hanamura, Kenji;Tinganelli, Walter, 2021, LIFE-BASEL, 11, 1

Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment, Zhang, Shenke;Ueno, Daishin;Ohira, Takashi;Kato, Hisashi;Izawa, Tetsuya;Yamanouchi, Sakuya;Yoshida, Yukari;Takahashi, Akihisa;Ohira, Yoshinobu, 2021, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9

⁶⁴Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity, Nachankar, Ankita;Oike, Takahiro;Hanaoka, Hirofumi;Kanai, Ayaka;Sato, Hiro;Yoshida, Yukari;Obinata, Hideru;Sakai, Makoto;Osu, Naoto;Hirota, Yuka;Takahashi, Akihisa;Shibata, Atsushi;Ohno, Tatsuya, 2021, CANCERS, 13, 24

Th Balance-Related Host Genetic Background Affects the Therapeutic Effects of Combining Carbon-Ion Radiation Therapy With Dendritic Cell Immunotherapy, Ma, Liqiu;Sakamoto, Yoshimitsu;Ando, Ken;Fujita, Hidetoshi;Takahashi, Akihisa;Takeshima, Tsuguhide;Otsuka, Hiromi;Ebner, Daniel K.;Kakimi, Kazuhiro;Imai, Takashi;Shimokawa, Takashi, 2022, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 112, 3, 780, 789

Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells, Beheshti, Afshin;McDonald, J. Tyson;Hada, Megumi;Takahashi, Akihisa;Mason, Christopher E.;Mognato, Maddalena, 2021, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22, 19

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Ju, Zhenlin;Thomas, Tamlyn N.;Chiu, Yi-Jen;Yamanouchi, Sakuya;Yoshida, Yukari;Abe, Jun-ichi;Takahashi, Akihisa;Wang, Jing;Fujiwara, Keigi;Hada, Megumi, 2022, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23, 11

Synthetic torpor protects rats from exposure to accelerated heavy ions, Puspitasari, Anggraeini;Squarcio, Fabio;Quartieri, Martina;Totis, Cristina;Hitrec, Timna;Takahashi, Akihisa;Yoshida, Yukari;Hanamura, Kenji;Yako, Tomoko;Cerri, Matteo;Simoniello, Palma;Durante, Marco;Tinganelli, Walter, 2022, SCIENTIFIC REPORTS, 12, 1

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Hirayama, Jun;Hattori, Atsuhiko;Takahashi, Akihisa;Furusawa, Yukihiro;Tabuchi, Yoshiaki;Shibata, Masahiro;Nagamatsu, Aiko;Yano, Sachiko;Maruyama, Yusuke;Matsubara, Hajime;Sekiguchi, Toshio;Suzuki, Nobuo, 2023, JOURNAL OF PINEAL RESEARCH, 74, 1

A new type of simulated partial gravity apparatus for rats based on a pully-spring system, Zhang, Shenke;Adachi, Takuya;Zhang, Shengli;Yoshida, Yukari;Takahashi, Akihisa, 2022, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10

Partial liver irradiation in rats induces the hypertrophy of nonirradiated liver lobes through hepatocyte proliferation^&DAG;, Adachi, Takuya;Yoshida, Yukari;Shibuya, Kei;Sato, Ken;Yamazaki, Yuichi;Kakizaki, Satoru;Uraoka, Toshio;Takahashi, Akihisa, 2023, JOURNAL OF RADIATION RESEARCH, 64, 4, 693, 701

The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Yamanouchi Sakuya;Adachi Takuya;Yoshida Yukari;Rhone Jordan;Mao Jian-Hua;Fujiwara Keigi;Saganti Premkumar B.;Takahashi Akihisa;Hada Megumi, 2021, Biological Sciences in Space, 35, 0, 15, 23

Partial liver irradiation in rats induces the hypertrophy of nonirradiated liver lobes through hepatocyte proliferation†., Adachi Takuya;Yoshida Yukari;Shibuya Kei;Sato Ken;Yamazaki Yuichi;Kakizaki Satoru;Uraoka Toshio;Takahashi Akihisa, Journal of radiation research, 64, 4

Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity., Malatesta Polina;Kyriakidis Konstantinos;Hada Megumi;Ikeda Hiroko;Takahashi Akihisa;Saganti Premkumar B;Georgakilas Alexandros G;Michalopoulos Ioannis, Jan. 2024, Biomolecules, 14, 1

;;;, Nov. 2019, 62回, 101

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;;;;, Oct. 2020, 63回, 75

Nov. 2021, 279, 6, 550

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Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars., Takahashi Akihisa;Yamanouchi Sakuya;Takeuchi Kazuomi;Takahashi Shogo;Tashiro Mutsumi;Hidema Jun;Higashitani Atsushi;Adachi Takuya;Zhang Shenke;Guirguis Fady Nagy Lotfy;Yoshida Yukari;Nagamatsu Aiko;Hada Megumi;Takeuchi Kunihito;Takahashi Tohru;Sekitomi Yuji, Nov. 2020, Life (Basel, Switzerland), 10, 11

Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b., Kim Eun Ho;Kim Jeong Yub;Kim Mi-Sook;Vares Guillaume;Ohno Tatsuya;Takahashi Akihisa;Uzawa Akiko;Seo Seung-Jun;Sai Sei, Dec. 2020, American journal of cancer research, 10, 12

Hibernation as a Tool for Radiation Protection in Space Exploration., Puspitasari Anggraeini;Cerri Matteo;Takahashi Akihisa;Yoshida Yukari;Hanamura Kenji;Tinganelli Walter, Jan. 2021, Life (Basel, Switzerland), 11, 1

Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment., Zhang Shenke;Ueno Daishin;Ohira Takashi;Kato Hisashi;Izawa Tetsuya;Yamanouchi Sakuya;Yoshida Yukari;Takahashi Akihisa;Ohira Yoshinobu, Jul. 2021, Frontiers in cell and developmental biology, 9

Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells., Beheshti Afshin;McDonald J Tyson;Hada Megumi;Takahashi Akihisa;Mason Christopher E;Mognato Maddalena, Sep. 2021, International journal of molecular sciences, 22, 19

Th Balance-Related Host Genetic Background Affects the Therapeutic Effects of Combining Carbon-Ion Radiation Therapy With Dendritic Cell Immunotherapy., Ma Liqiu;Sakamoto Yoshimitsu;Ando Ken;Fujita Hidetoshi;Takahashi Akihisa;Takeshima Tsuguhide;Otsuka Hiromi;Ebner Daniel K;Kakimi Kazuhiro;Imai Takashi;Shimokawa Takashi, Nov. 2021, International journal of radiation oncology, biology, physics, 112, 3

64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity., Nachankar Ankita;Oike Takahiro;Hanaoka Hirofumi;Kanai Ayaka;Sato Hiro;Yoshida Yukari;Obinata Hideru;Sakai Makoto;Osu Naoto;Hirota Yuka;Takahashi Akihisa;Shibata Atsushi;Ohno Tatsuya, Dec. 2021, Cancers, 13, 24

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector., Ju Zhenlin;Thomas Tamlyn N;Chiu Yi-Jen;Yamanouchi Sakuya;Yoshida Yukari;Abe Jun-Ichi;Takahashi Akihisa;Wang Jing;Fujiwara Keigi;Hada Megumi, May 2022, International journal of molecular sciences, 23, 11

A new type of simulated partial gravity apparatus for rats based on a pully-spring system., Zhang Shenke;Adachi Takuya;Zhang Shengli;Yoshida Yukari;Takahashi Akihisa, Aug. 2022, Frontiers in cell and developmental biology, 10

Synthetic torpor protects rats from exposure to accelerated heavy ions., Puspitasari Anggraeini;Squarcio Fabio;Quartieri Martina;Totis Cristina;Hitrec Timna;Takahashi Akihisa;Yoshida Yukari;Hanamura Kenji;Yako Tomoko;Cerri Matteo;Simoniello Palma;Durante Marco;Tinganelli Walter, Sep. 2022, Scientific reports, 12, 1

;;;;, Aug. 2021, 71, 3, 237

;, Aug. 2022, 38, Suppl., 036

Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody, Liqiu Ma; Yang Li; Yoshimitsu Sakamoto; Lin Xie; Saaya Suzuki; Yukari Yoshida; Li Sui; Gang Guo; Jialing Wen; Wangcai Ren; Kazuhiro Kakimi; Kensuke Osada; Akihisa Takahashi; Takashi Shimokawa, Dec. 2024, Neoplasia, 60, 101099, Scientific journal

Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles, Shengli Zhang; Shenke Zhang; Zhen Wang; Takuya Adachi; Yukari Yoshida; Akihisa Takahashi, Aug. 2024, Life Sciences in Space Research, 43, 54, 67, Scientific journal

Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 Apc/+ mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, May 2024, Life Sciences in Space Research, 41, 202, 209, Scientific journal

Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity, Polina Malatesta; Konstantinos Kyriakidis; Megumi Hada; Hiroko Ikeda; Akihisa Takahashi; Premkumar Saganti; Alexandros Georgakilas; Ioannis Michalopoulos, No, No, No, Jan. 2024, Biomolecules, 14, 1, 88, Scientific journal

Partial liver irradiation in rats induces the hypertrophy of non-irradiated liver lobes through hepatocyte proliferation, Takuya Adachi; Yukari Yoshida; Kei Shibuya; Ken Sato; Yuichi Yamazaki; Satoru Kakizaki; Toshio Uraoka; Akihisa Takahashi, Yes, Yes, 2023, J Radiat Res, 64, 693, 701, Scientific journal

Synthetic torpor protects rats from exposure to accelerated heavy ions, Anggraeini Puspitasari; Fabio Squarcio; Martina Quartieri; Cristina Totis; Timna Hitrec; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Tomoko Yako; Matteo Cerri; Palma Simoniello; Marco Durante; Walter Tinganelli, 30 Sep. 2022, Scientific Reports, 12, 1, 16405, 16405, Scientific journal

A new type of simulated partial gravity apparatus for rats based on a pully-spring system, Shenke Zhang; Takuya Adachi; Shengli Zhang; Yukari Yoshida; Akihisa Takahashi, Yes, Yes, Aug. 2022, Front Cell Dev Biol ., 10, 965656, Scientific journal

Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Zhenlin Ju; Tamlyn Thomas; Yi-Jen Chiu; Sakuya Yamanouchi; Yukari Yoshida; Jun-ichi Abe; Akihisa Takahashi; Jing Wang; Keigi Fujiwara; Megumi Hada, May 2022, International Journal of Molecular Sciences, 23, 6127, Scientific journal

⁶⁴Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity, ANKITA NACHANKAR; Takahiro Oike; Hirofumi Hanaoka; Ayaka Kanai; Hiro Sato; Yukari Yoshida; Hideru Obinata; Makoto SAKAI; Naoto Osu; Yuka Hirota; Akihisa Takahashi; Atsushi Shibata; Tatsuya Ohno, Dec. 2021, Cancers, Scientific journal

Th balance related host genetic background affects the therapeutic effects of combining carbon-ion radiotherapy with dendritic cell immunotherapy, Liqiu Ma; Yoshimitsu Sakamoto; Ken Ando; Hidetoshi Fujita; Akihisa Takahashi; Tsuguhide Takeshima; Hiromi Otsuka; Daniel K Ebner; Kazuhiro Kakimi; Takashi Imai; Takashi Shimokawa, Nov. 2021, Int J Radiat Oncol Biol Phys, 112, 3, 3780, 789, Scientific journal

The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, Jul. 2021, Biological Sciences in Space, 35, 15, 23, Scientific journal

Depression of Bone Density at the Weight-bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated with a Partial Gravity Environment, Shenke Zhang; Daishin Ueno; Takashi Ohira; Hisashi Kato; Tetsuya Izawa; Sakuya Yamanouchi; Yukari Yoshida; Akihisa Takahashi; Yoshinobu Ohira, Jun. 2021, Frontiers in Cell and Development Biology, 9, 707470, Scientific journal

Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations, Sakuya Yamanouchi; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, Sep. 2020, Life, 10, 9, 187, Scientific journal

Inhibition of the ATR kinase enhances 5-FU sensitivity independently of non-homologous end-joining and homologous recombination repair pathways., Soichiro S Ito; Yosuke Nakagawa; Masaya Matsubayashi; Yoshihiko M Sakaguchi; Shinko Kobashigawa; Takeshi K Matsui; Hitoki Nanaura; Mari Nakanishi; Fumika Kitayoshi; Sotaro Kikuchi; Atsuhisa Kajihara; Shigehiro Tamaki; Kazuma Sugie; Genro Kashino; Akihisa Takahashi; Masatoshi Hasegawa; Eiichiro Mori; Tadaaki Kirita, 16 Jul. 2020, J Biol Chem, 295, 37, 12946, 12961, Scientific journal

Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells, Eun Ho Kim; Mi-Sook Kim; Akihisa Takahashi; Masao Suzuki; Guillaume Vares; Akiko Uzawa; Akira Fujimori; Tatsuya Ohno; Sei Sai, Mar. 2020, Cancers, 12, 698, Scientific journal

Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells, Ju Yeon Oh; Eun Ho Kim; Yeon-Joo Lee; Sei Sai; Sun Ha Lim; Jang Woo Park; Hye Kyung Chung; Joon Kim; Guillaume Vares; Akihisa Takahashi; Youn Kyoung Jeong; Mi-Sook Kim; Chang-Bae Kong, Nov. 2019, Cancers, 11, 1812, Scientific journal

X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity, Anggraeini Puspitasari; Hiroyuki Yamazaki; Hidemasa Kawamura; Takashi Nakano; Akihisa Takahashi; Tomoaki Shirao; Kathryn Held, Nov. 2019, Neuroscience Research, S0168-0102, 19, 30320, 30327, Scientific journal

Anti-Metastatic Benefits Produced by Hyperthermia and a CCL3 Derivative, Liqiu Ma; Ryosuke Kambe; Tomoko Tsuchiya; Shiro Kanegasaki; Akihisa Takahashi, Nov. 2019, Cancers, 11, 11, 1770, Scientific journal

Melatonin is a potential drug for the prevention of bone loss during space flight, Mika Ikegame; Atsuhiko Hattori; Makoto J. Tabata; Kei-ichiro Kitamura; Yoshiaki Tabuchi; Yukihiro Furusawa; Yusuke Maruyama; Tatsuki Yamamoto; Toshio Sekiguchi; Risa Matsuoka; Taizo Hanmoto; Takahiro Ikari; Masato Endo; Katsunori Omori; Masaki Nakano; Sayaka Yashima; Sadakazu Ejiri; Toshiki Taya; Hiroshi Nakashima; Nobuaki Shimizu; Masahisa Nakamura; Takashi Kondo; Kazuichi Hayakawa; Ichiro Takasaki; Atsushi Kaminishi; Ryosuke Akatsuka; Yuichi Sasayama; Takumi Nishiuchi; Masayuki Nara; Hachiro Iseki; Vishwajit S. Chowdhury; Shigehito Wada; Kenichi Ijiri; Toshio Takeuchi; Tohru Suzuki; Hironori Ando; Kouhei Matsuda; Masanori Somei; Hiroyuki Mishima; Yuko Mikuni-Takagaki; Hisayuki Funahashi; Akihisa Takahashi; Yoshinari Watanabe; Masahiro Maeda; Hideaki Uchida; Akio Hayashi; Akira Kambegawa; Azusa Seki; Sachiko Yano; Toru Shimazu; Hiromi Suzuki; Jun Hirayama; Nobuo Suzuki, Oct. 2019, Journal of Pineal Research, 67, 3, e12594, Scientific journal

Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida; Akihisa Takahashi, Sep. 2019, International Journal of Molecular Science, 20, 19, 4791, Scientific journal

Effects of p53 status of tumor cells and combined treatment with mild hyperthermia, wortmannin or caffeine on recovery from radiation-induced damage., Shin-Ichiro Masunaga; Keizo Tano; Yu Sanada; Minoru Suzuki; Akihisa Takahashi; Ken Ohnishi; Koji Ono, Jun. 2019, World Journal of Oncology, 10, 3, 132, 141, Scientific journal

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Hiroko Ikeda; Jordan R. Rhone; Andrew J. Beitman; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn D. Held; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi, Dec. 2018, International Journal of Molecular Sciences, 20, 43, Scientific journal

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice, Akihisa Takahashi; Shoto Wakihata; Liqiu Ma; Takuya Adachi; Hiroki Hirose; Yukari Yoshida; Yoshinobu Ohira, Dec. 2018, International Journal of Molecular Sciences, 19, 3959, Scientific journal

X-ray irradiation induces disruption of the blood–brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain, Yukari Yoshida; Yukihiko Sejimo; Masashi Kurachi; Yasuki Ishizaki; Takashi Nakano; Akihisa Takahashi, Oct. 2018, Neurochemistry International, 119, 199, 206, Scientific journal

In vivo and in vitro immunochemical assay for CNS synaptic dysfunction by X-irradiation, Shirao Tomoaki; Puspitasari Anggraeini; Koganezawa Noriko; Kawamura Hidemasa; Takahashi Akihisa; Sekino Yuko; Nakano Takashi; Held Kathryn D, Sep. 2018, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 93, 136, 136

BRCA2 protects mammalian cells from heat shock., Yosuke Nakagawa; Atsuhisa Kajihara; Akihisa Takahashi; Akiho S Murata; Masaya Matsubayashi; Soichiro S Ito; Ichiro Ota; Takahiko Nakagawa; Masatoshi Hasegawa; Tadaaki Kirita; Takeo Ohnishi; Eiichiro Mori, Sep. 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 34, 6, 795, 801, Scientific journal

Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system, Hiroko Ikeda; Hikaru Souda; Anggraeini Puspitasari; Kathryn D. Held; Jun Hidema; Takeshi Nikawa; Yukari Yoshida; Tatsuaki Kanai; Akihisa Takahashi, 01 Feb. 2017, Life Sciences in Space Research, 12, 51, 60, Scientific journal

Future Scenario of the Space Radiation Research Using Space Environment, Akihisa Takahashi; Jun Hidema; Hiroshi Yasuda, 2017, INTERNATIONAL JOURNAL OF MICROGRAVITY SCIENCE AND APPLICATION, 34, 2, Scientific journal

Targeting of carbon ion-induced G2 checkpoint activation in lung cancer cells using Wee-1 inhibitor MK-1775, Hongyu Ma; Akihisa Takahashi; Yukihiko Sejimo; Akiko Adachi; Nobuteru Kubo; Mayu Isono; Yukari Yoshida; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Dec. 2015, Radiation Research, 184, 6, 660, 669, Scientific journal

Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells, Hongyu Ma; Akihisa Takahashi; Yukari Yoshida; Akiko Adachi; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Nov. 2015, RADIATION ONCOLOGY, 10, 225, Scientific journal

Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells, Mayu Isono; Yukari Yoshida; Akihisa Takahashi; Takahiro Oike; Atsushi Shibata; Yoshiki Kubota; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Sep. 2015, JOURNAL OF RADIATION RESEARCH, 56, 5, 856, 861, Scientific journal

May 2015, 65, 2, 167, 167

Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460, Nobuteru Kubo; Shin-ei Noda; Akihisa Takahashi; Yukari Yoshida; Takahiro Oike; Kazutoshi Murata; Atsushi Musha; Yoshiyuki Suzuki; Tatsuya Ohno; Takeo Takahashi; Takashi Nakano, Mar. 2015, JOURNAL OF RADIATION RESEARCH, 56, 2, 229, 238, Scientific journal

Sep. 2014, 57回, 130, 130

Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation, Akihisa Takahashi; Makoto Kubo; Hongyu Ma; Akiko Nakagawa; Yukari Yoshida; Mayu Isono; Tatsuaki Kanai; Tatsuya Ohno; Yoshiya Furusawa; Tomoo Funayama; Yasuhiko Kobayashi; Takashi Nakano, Sep. 2014, Radiation Research, 182, 3, 338, 344, Scientific journal

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells, Kazutoshi Murata; Shin-ei Noda; Takahiro Oike; Akihisa Takahashi; Yukari Yoshida; Yoshiyuki Suzuki; Tatsuya Ohno; Tomoo Funayama; Yasuhiko Kobayashi; Takeo Takahashi; Takashi Nakano, Jul. 2014, Journal of Radiation Research, 55, 4, 658, 664, Scientific journal

Jun. 2014, 49, 3, 1696, 1696

The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells, Yosuke Nakagawa; Atsuhisa Kajihara; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Tadaaki Kirita; Takeo Ohnishi, May 2014, ONCOLOGY REPORTS, 31, 5, 2001, 2006, Scientific journal

Degradation of initiator tRNA(Met) by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells, Kazunori Watanabe; Ryu Miyagawa; Chie Tomikawa; Rie Mizuno; Akihisa Takahashi; Hiroyuki Hori; Kenichi Ijiri, Apr. 2013, NUCLEIC ACIDS RESEARCH, 41, 8, 4671, 4685, Scientific journal

Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight, Akihisa Takahashi; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Takeo Ohnishi, Mar. 2012, JOURNAL OF RADIATION RESEARCH, 53, 2, 168, 175, Scientific journal

DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines, Yukihiro Furusawa; Yoshisada Fujiwara; Paul Campbell; Qing-Li Zhao; Ryohei Ogawa; Mariame Ali Hassan; Yoshiaki Tabuchi; Ichiro Takasaki; Akihisa Takahashi; Takashi Kondo, Jan. 2012, PLOS ONE, 7, 1, e29012, Scientific journal

Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G(2)/M Phase-dependent, Xiaoming Su; Akihisa Takahashi; Natsuko Kondo; Yosuke Nakagawa; Toshiyasu Iwasaki; Guozhen Guo; Takeo Ohnishi, Sep. 2011, JOURNAL OF RADIATION RESEARCH, 52, 5, 609, 615, Scientific journal

Heat induces gamma H2AX foci formation in mammalian cells, Akihisa Takahashi; Eiichiro Mori; Georgios I. Somakos; Ken Ohnishi; Takeo Ohnishi, Oct. 2008, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 656, 1-2, 88, 92, Scientific journal

Proposal from space radiation biologists. Importance of Centrifuge Facility in the study of biological effect by space radiation, A. Takahashi; T. Ohnishi, 2001, Biological sciences in space = Uchū seibutsu kagaku, 15, 3, 167, 171, Scientific journal

Space radiation biology, A. Takahashi; T. Ohnishi, 2001, Biological sciences in space = Uchū seibutsu kagaku, 15, 1, 40, 46, Scientific journal

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress, H Matsumoto; A Takahashi; XJ Wang; K Ohnishi; T Ohnishi, Aug. 1997, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 39, 1, 197, 203, Scientific journal

Goldfish regenerated scale culture at low temperatures improves osteoblast and osteoclast survival in scales without loss of the osteoblast and osteoclast response to changes in gravity, Nobuo Suzuki; Kouhei Kuroda; Mika Ikegame; Harumi Takino; Keito Tsunoda; Riku Izumi; Masato Endo; Yoshiaki Tabuchi; Hajime Matsubara; Sachiko Yano; Yukihiro Furusawa; Toru Shimazu; Koji Yachiguchi; Masato Honda; Yusuke Maruyama; Kazuki Watanabe; Akihisa Takahashi; Jun Hirayama; Atsuhiko Hattori, Apr. 2025, Life Sciences in Space Research

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Jun Hirayama;Atsuhiko Hattori;Akihisa Takahashi;Yukihiro Furusawa;Yoshiaki Tabuchi;Masahiro Shibata;Aiko Nagamatsu;Sachiko Yano;Yusuke Maruyama;Hajime Matsubara;Toshio Sekiguchi;Nobuo Suzuki, No, No, No, 06 Oct. 2022, J Pineal Res ., Introduction scientific journal

Genomic changes driven by radiation-induced DNA damage and microgravity in human cells, Afshin Beheshti , J. Tyson McDonald , Megumi Hada , Akihisa , Takahashi , Christopher E Mason , Maddalena Mognato, No, No, No, 29 Sep. 2021, Int J Mol Sci., 22, 19, 10507

Hibernation as a tool for radiation protection in space exploration, Anggraeini Puspitasari; Matteo Cerri; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Walter Tinganelli, Jan. 2021, Life, 11, 1, 54, Introduction scientific journal

Space radiation biology for “Living in Space”, Satoshi Furukawa; Aiko Nagamatsu; Mitsuru Nenoi; Akira Fujimori; Shizuko Kakinuma; Takanori Katsube; Bing Wang; Chizuru Tsuruoka; Toshiyuki Shirai; Asako J. Nakamura; Asako Sakaue-Sawano; Atsushi Miyawaki; Hiroshi Harada; Minoru Kobayashi; Junya Kobayashi; Takekazu Kunieda; Tomoo Funayama; Michiyo Suzuki; Tatsuo Miyamoto; Jun Hidema; Yukari Yoshida; Akihisa Takahashi, Mar. 2020, BioMed Research International, 2020, 4703286, 4703286, Introduction scientific journal

How does spaceflight affect the acquired immune system?, Taishin Akiyama; Kenta Horie; Eiichi Hinoi; Manami Hiraiwa; Akihisa Kato; Yoichi Maekawa; Akihisa Takahashi; Satoshi Furukawa, 2020, NPJ microgravity, 6, 14, 14, Introduction scientific journal

Feb. 2019, 51, 2, 24, 27, Introduction commerce magazine

Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks, Akihisa Takahashi; Hiroko Ikeda; Yukari Yoshida, Aug. 2018, International Journal of Particle Therapy, 5, 1, 151, 159, Introduction scientific journal

Oct. 2018, 50, 591, 596, Introduction commerce magazine

Apr. 2018, 69, 2, 152, 156, Introduction commerce magazine

Apr. 2017, 34, 2, 340203, Introduction scientific journal

ヒト膵癌細胞におけるLPA受容体を介した遊走・浸潤と放射線治療戦略, 小町麻由美; 野田真永; 村田和俊; 中野隆史; 高橋昭久; 岡本雅彦; 鈴木義行, 2016, Kitakanto Medical Journal, 66, 4, 297(J‐STAGE)

Effects of charged particles on human tumor cells, Kathryn D. Held; Hidemasa Kawamura; Takuya Kaminuma; Athena Evalour S. Paz; Yukari Yoshida; Qi Liu; Henning Willers; Akihisa Takahashi, 2016, Frontiers in Oncology, 6, 23, Book review

Jun. 2015, 64, 6, 371, 381, Introduction scientific journal

01 May 2015, 65, 2, 171, 172

Therapeutic strategies for head and neck cancer based on p53 status (Review), Ichiro Ota; Noritomo Okamoto; Katsunari Yane; Akihisa Takahashi; Takashi Masui; Hiroshi Hosoi; Takeo Ohnishi, Apr. 2012, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 3, 4, 585, 591, Book review

2011年度生物科学系スモールペイロード宇宙実験研究チーム活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2012, 宇宙利用シンポジウム, 28th, 185, 186

2010年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2011, 宇宙利用シンポジウム, 27th, 219, 220

2011

2011

Signal Transduction of Radiation and/or Hyperthermic Cancer Therapies, Takeo Ohnishi; Akihisa Takahashi, Sep. 2010, CURRENT SIGNAL TRANSDUCTION THERAPY, 5, 3, 231, 236, Book review

平成21年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2010, 宇宙利用シンポジウム, 26th, 201, 202

Molecular Mechanisms Involved in Adaptive Responses to Radiation, UV light, and Heat, Akihisa Takahashi; Takeo Ohnishi, Sep. 2009, JOURNAL OF RADIATION RESEARCH, 50, 5, 385, 393, Book review

2009, 44, 2, 140, 153

Expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment., Ohnishi T; Takahashi A; Suzuki H; Omori K; Shimazu T; Ishioka N, 2009, Biol Sci Space., 23, 3, 10, Introduction scientific journal

2009, 23, 11, 16

Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes (vol 24, pg 605, 2008), A. Kajihara; A. Takahashi; K. Ohnishi; Y. Imai; N. Yamakawa; J. Yasumoto; T. Ohnishi; T. Kirita, 2009, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 25, 5, 403, 404, Others

温熱誘導DNA二本鎖切断の生物学(The Biology of Heat-Induced DNA Double-Strand Breaks), 森 英一朗; 高橋 昭久; 大西 武雄, Jun. 2008, Thermal Medicine, 24, 2, 39,(54), 50,(54)

p53 targeting can enhance cancer therapy via radiation, heat and anti-cancer agents, Takeo Ohnishi; Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi, Jun. 2008, ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 8, 5, 564, 570, Book review

平成19年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 最上善広; 永瀬睦; 嶋津徹; 藤本信義; 山崎丘; 石岡憲昭, Mar. 2008, 宇宙利用シンポジウム, 24th, 337, 338

2008, 25, 695, 700

2008, 25, 686, 690

2008, 43, 1, 91, 99

2008, 43, 4, 409, 423

Vanguards of paradigm shift in radiation biology: Radiation-induced adaptive and bystander responses, Hideki Matsumoto; Nobuyuki Hamada; Akihisa Takahashi; Yasuhiko Kobayashi; Takeo Ohnishi, Mar. 2007, JOURNAL OF RADIATION RESEARCH, 48, 2, 97, 106, Book review

線虫(C.elegans)を用いる回収衛星宇宙実験研究班WG活動報告, 石岡憲昭; 石原昭彦; 宇佐美真一; 高橋昭久; 夏井坂誠; 二川健; 東谷篤志; 東端晃; 藤本信義; 馬嶋秀行; 保田浩志; 山崎丘, Mar. 2007, 宇宙利用シンポジウム, 23rd, 340, 341

平成18年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 最上善広; 永瀬睦; 嶋津徹; 藤本信義; 山崎丘; 石岡憲昭, Mar. 2007, 宇宙利用シンポジウム, 23rd, 342, 343

Does gamma H2AX foci formation depend on the presence of DNA double strand breaks? (vol 229, pg 171, 2005), A Takahashi; T Ohnishi, May 2006, CANCER LETTERS, 236, 1, 155, 156, Others

What is the critical hyperthermia target in cancer cells?, Takahashi A; Ohnishi T, 2006, Jpn J Hyperthermic Oncol (Thermal Med)., 22, 229, 237, Introduction scientific journal

Does gamma H2AX foci formation depend on the presence of DNA double strand breaks?, A Takahashi; T Ohnishi, Nov. 2005, CANCER LETTERS, 229, 2, 171, 179, Book review

A possible role of DNA double strand breaks in heat-induced cell killing - In response, A Takahashi; E Mori; T Ohnishi, Nov. 2005, CANCER RESEARCH, 65, 22, 10633, 10633, Report scientific journal

2005, 22, 151, 154

2005, 40, 139, 147

2004, -HIMAC10周年記念 研究成果要覧-, 131, 135

Radiation-induced adaptive responses and bystander effects., Matsumoto H; Takahashi A; Ohnishi T, 2004, Biol Sci Space., 18, 247, 254, Introduction scientific journal

The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space Station., Takahashi A; Ohnishi T, 2004, Biol Sci Space., 18, 255, 260, Introduction scientific journal

Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation, A. Takahashi; K. Ohnishi; T. Ohnishi, 2004, International Journal of Low Radiation, 1, 2, 199, 207

The role of p53 molecule in radiation and hyperthermic therapies, J Yasumoto; A Takahashi; K Ohnishi; T Ohnishi, Aug. 2003, JOURNAL OF HEALTH SCIENCE, 49, 4, 273, 277, Book review

2003

2003, 38, 3, 245, 259

Pre-irradiation at a low dose-rate blunted p53 response, A Takahashi, Mar. 2002, JOURNAL OF RADIATION RESEARCH, 43, 1, 1, 9, Book review

Radiobiological characteristics of solid tumors depending on the p53 status of the tumor cells -- reference to the response of intratumor quiescent cells., Masunaga S; Takahashi A; Ohnishi T; Takagaki M; Kinashi Y; Ono K, 2002, the 6th International Symposium on Predictive Oncology and Therapy, 0, 0

2002, 48, 324, 327

2002, 62, 3, 6

Radiation biology in space: DNA damage and biological effects of space radiation., Ohnishi T; Takahashi A; Ohnishi K, 2002, J Photosci., 9, 37, 40, Introduction scientific journal

2002, 22, 2037, 2043

2002, 50, 56

2001, 15, 167, 171

2001, 15, 40, 46

2001, 36, 4, 401, 412

Biological effects of space radiation., Ohnishi T; Takahashi A; Ohnishi K, 2001, Biol Sci Space., 15, 203, 210, Introduction scientific journal

2000, 18, 156, 157

2000, 35, 152, 163

2000, 35, 67, 79

Unique postural control of upside-down swimming catfish, Synodontis nigriventris, not affected by the change of gravity., Akihisa Takahashi, 01 Jul. 2000, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 7, 97, 98

Enzymic chemical reaction under microgravity environment in space., Ohnishi T; Takahashi A; Ohnishi K; Nakano T; Nagaoka S, 2000, J Gravit Phys., 7, 69, 70

Relationship between p53 status and amount of hsp72 induction in human cancer cell, A Tsubakimoto; K Ohnishi; A Takahashi; M Hatoko; T Muramatsu; T Shirai; T Ohnishi, Apr. 1999, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 112, 4, 589, 589, Summary international conference

1999, 17, 108, 109

1999, 34, 1, 86, 97

DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment, OHNISHI Takeo; TAKAHASHI Akihisa; OHNISHI Ken; MATSUMOTO Hideki, 1999, Biological Sciences in Space, 13, 2, 82, 87

Behavior and development of animals in outer space., TAKAHASHI Akihisa; OHNISHI Ken; OHNISHI Takeo, 1999, KAGAKU TO SEIBUTSU, 37, 6, 404, 407

1998, 33, 4, 338, 350

1998, 9, 117, 120

1998, 44, 183, 184

1998, 8, 15, 19

1997, 9, 1, 13

1996, 31, 52, 61

1996, 31, 3, 232, 245

1995, 30, 286, 298

1995, 30, 105, 117

LICHT-INDUCED ANTHOCYANIN REDUCES THE EXTENT OF DAMAGE TO DNA IN UV-IRRADIATED CENTAUREA-CYANUS CELLS IN CULTURE, T OHNISHI; A TAKAHASHI; K TAKEDA, Dec. 1992, MUTATION RESEARCH, 272, 3, 277, 277, Summary international conference

Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara, Toshio Sekiguchi, Nobuo Suzuki, Oct. 2022, Journal of Pineal Research, e12834

Study for Managing Space Radiation Risk in Deep Space, Akihisa Takahashi, Yes, Yes, Nov. 2021, Igaku no ayumi, 279, 6, 550, 554, Introduction commerce magazine

Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells, Afshin Beheshti; John McDonald; Megumi Hada; Akihisa Takahashi; Christopher E Mason; Maddalena Mognato, Sep. 2021, International Journal of Molecular Sciences, Introduction scientific journal

Research on Combined Effects of Space Radiation and Variable Gravity, Takahashi Akihisa; Kambe Ryosuke; Suzuki Kenshi; Tsuruoka Chizuru; Morioka Takamitsu; Takeshima Tsuguhide; Yoshida Yukari; Nakamura Asako; Hada Megumi; Nagamatsu Aiko; Ohira Yoshinobu; Inatomi Yuko; Kakinuma Shizuko, Jan. 2020, 34

Combined effects of variable gravity and simulated solar UV light on plant in space, Hidema Jun; Kitaya Yoshiaki; Takahashi Akihisa; Inatomi Yuko, Jan. 2018, 32

01 May 2015, 65, 2, 165, 165

The scientific aspects of hyperthermic cancer therapy, Akihisa Takahashi; Takeo Ohnishi, Nov. 2006, Biotherapy, 20, 6, 515, 520, Book review

Aug. 2006, 76, 8, 824, 826

Mar. 2006, 8, 10

Pre-irradiation with a Low Dose-rate Depressed Radiation-induced Biological Effects (2), TAKAHASHI Akihisa; OHNISHI Ken; TACHIBANA Akira; KUNUGITA Naoki; NORIMURA Toshiyuki; OHNISHI Takeo, 01 Nov. 2002, 16, 3, 195, 196

Study of Biological Response by Pre-irradiation at a Low Dose or a Low Dose-rate, OHNISHI Takeo; TAKAHASHI Akihisa; OHNISHI Ken, 01 Nov. 2002, 16, 3, 103, 104

Accumulation of p53 and induction of apoptosis gene by low dose ionizing radiation and/or artificial gravity, OKAICHI Kumio; OKUMURA Yutaka; OHNISHI Ken; TAKASASHI Akihisa; OHINISHI Takeo, Sep. 1999, 13, 3, 242, 243

Expression of tumor suppressor gene in cells after low dose or low dose rate irradiation, OHNISHI Takeo; OHNISHI Ken; TAKAHASHI Akihisa, Sep. 1999, 13, 3, 244, 245

The effect of microgravity on induced mutation through DNA synthesis during space flight, TAKAHASHI Akihisa; OHNISHI Ken; FUKUI Mitsuyo; NAKANO Tamotsu; NAGAOKA Shunji; OHINISHI Takeo, Sep. 1999, 13, 3, 234, 235

SOS response in X-ray- or UV-irradiated E. coli cells under microgravity, OHINISHI Ken; TAKAHASHI Akihisa; NAKANO Tamotsu; NAGAOKA Shunji; OHNISHI Takeo, Sep. 1999, 13, 3, 232, 233

Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody, Liqiu Ma; Yang Li; Yoshimitsu Sakamoto; Lin Xie; Saaya Suzuki; Yukari Yoshida; Li Sui; Gang Guo; Jialing Wen; Wangcai Ren; Kazuhiro Kakimi; Kensuke Osada; Akihisa Takahashi; Takashi Shimokawa, Jun. 2024, International Journal of Particle Therapy, 12, 63, 64, Summary international conference

The DAMPs mediate the distal tumor rejection and metastasis inhibition induced by carbon ion beam., Jialing Wen; Akihisa Takahashi; Yukari Yoshida; Wangcai Ren; Xuanzhang Tu; Li Sui; Gang Guo; Takashi; Shimokawa; Liqiu Ma, Jun. 2024, International Journal of Particle Therapy, 12, 84, Summary international conference

Metastasis inhibition at multiple sites induced by carbon ions., Wangcai Ren; Akihisa Takahashi; Yukari Yoshida; Jialing Wen; Xuanzhang Tu; Li Sui; Gang Guo; Takashi Shimokawa; Liqiu Ma, Jun. 2024, International Journal of Particle Therapy,, 12, 63, Summary international conference

Nov. 2011, Summary national conference

硼素中性子捕捉反応による抗腫瘍効果に対するp53 statusの関与の可能性, 増永 慎一郎; 小野 公二; 鈴木 実; 永田 憲司; 高橋 昭久; 大西 武雄, Oct. 2002, 日本癌学会総会記事, 61回, 182, 182

Contributor, 30 Nov. 2020, 1174, 1123-1127, Dictionary or encycropedia, 978-4-621-30561-4

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23 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference

Increases chromosome aberrations in human cells exposed simultaneously to simulated microgravity and neutron, M. Hada, H. Ikeda, P.B. Saganti, A. Takahashi, ASGSR2022, Nov. 2022, English, Houston, United States, International conference

07 Oct. 2020, Japanese, Japan, Domestic conference

23 Feb. 2020, Japanese

21 Jan. 2020, Japanese

RNA sequencing of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Takahashi A; Ikeda H; Muratani M; Hidema J; Fujiwara K; Souda H; Yoshida Y; Hada M, 2020 NASA Human Research Program Investigators' Workshop, 30 Jan. 2020, English

Increased chromosome aberrations in lymphoblastoid cells exposed simultaneously to simulated microgravity and radiation, Yamanouchi S; Rhone J; Takahashi A; Hada M, 2020 NASA Human Research Program Investigators' Workshop, 30 Jan. 2020

How to research about simulated space environments on the Earth, TAKAHASHI Akihisa, International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS2019), Kiryu, Japan, 04 Dec. 2019, English, International conference

Assessment of Cancer Risk from Radiation Hazard in Space, TAKAHASHI Akihisa, The 3rd International Moon Village Workshop and Symposium, 05 Dec. 2019, English, International conference

30 Oct. 2019, Japanese, Domestic conference

16 Nov. 2019, Japanese, Domestic conference

Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Jordan Rhone; Andrew J Beitman; Hiroko Ikeda; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn D Held; Keigi Fujiwara; Premkumar B Saganti; Akihisa Takahashi, ASGSR2019, 20 Nov. 2019, English, International conference

Expression Profile of Cell Cycle-related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity, Akihisa Takahashi; Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida, ASGSR2019, 21 Nov. 2019, English, International conference

22 Sep. 2019, Japanese, Domestic conference

21 Sep. 2019, Japanese, Domestic conference

06 Sep. 2019, Japanese, Domestic conference

Is gravity parameter necessary for cancer risk assessment in long-term manned space missions?, Akihisa Takahashi, ISRBW2019, Dalian, China, 30 Sep. 2019, English, International conference

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-limb Unloading, Akihisa Takahashi; Shoto Wakihata; Liqiu Ma; Takuya Adachi; Yukari Yoshida; Yoshinobu Ohira, ISTS2019, Fukui, Japan, 19 Jun. 2019, English, International conference

Space Experiments for "Cancer Progression" in the International Space Station, Akihisa Takahashi; Masafumi Muratani; Asako Sawano; Atushi Miyawaki, ISGP2019, Nagoya, Japan, 26 May 2019, English, International conference

Future space experiments for “cancer risk assessment” in the ISS and the Gateway, TAKAHASHI Akihisa, SMME2019, Kiryu, Japan, 20 Mar. 2019, English, International conference

Gunma University Heavy Ion Medical Center (GHMC): Therapy and Space Research, TAKAHASHI Akihisa, ICTSS2019, Kiryu, Japan, 08 May 2019, English, International conference

24 Jan. 2019, Japanese, Domestic conference

01 Mar. 2019, Japanese, Domestic conference

The synergistic effect of simulated microgravity and charged particle radiation on gene expression in human fibroblasts., Ikeda H; Muratani M; Puspitasari A; Held KD; Hidema J; Yoshida Y; Takahashi A, 42nd COSPAR, Jul. 2018, English, International conference

15 Sep. 2018, Japanese, Domestic conference

16 Sep. 2018, Japanese, Domestic conference

23 Sep. 2018, Japanese, Domestic conference

25 Jan. 2019, Japanese, Domestic conference

Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation., Rhone JR; Beitman A; Ikeda H; Souda H; Yoshida Y; Held KD; Fujiwara K; Takahashi A; Saganti PB; Hada M, 2019 NASA Human Research Program Investigators' Workshop, Jan. 2019, English, International conference

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New p53-targeted gene or chemical chaperone therapy in radiation and hyperthermic oncologies., Eur Symp Hyperthermic Oncol., 2002

New p53-targeted therapy combined with gene or chemical chaperone therapy with radiation and hyperthernic cancer therapies., 1st Congr Egypt Soci Hyperthermic Therapy., 2002

New hyperthermic therapies based on p53 gene status., 26th Congr Int Clin Hyperthermia Soc., 2004

New hyperthermic therapy based on p53 gene status., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004

(The young investigator Award of JSHO) Dynamics of DNA damage-recognizing proteins at heat-induced foci., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006

Accumulation of wild-type p53 is induced by heat treatment in a heat resistant human cancer cell line., 10th Radiat Biol Center Int Symp,, 1993

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation., 11th Int Congr Radiat Res., 1999

New strategy of hyperthermic therapy combined to gene therapy or chemical chaperone therapy., 8th Int Congr Hyperthermic Oncol., 2000

p53 status-based cancer therapy., Jpn-China Radiat Oncol Symp Kyoto., 2001

DNA-PK activity plays an important role in radioadaptation by pre-irradiation with low-dose or low-dose rate in mouse spleen., Int Symp Radiat Health., 2001

DNA-PK activity depressed radioadaptation of apoptosis induced by pre-irradiation at low-dose or low-dose rate in mouse spleen., Int Symp Radiat Homeostasis., 2001

Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation., 1st Radiat Protect Asia-Oceania., 2002

Radiation-induced apoptosis in Scid mouse spleen after a low-dose irradiation., 34th COSPAR., 2002

New p53-targeted therapy combined with gene or chemical chaperone therapy., 19th Radiat Biol Cent Int Symp., 2002

Restoration of mp53 to wtp53 by chemical chaperones brought p53-dependent apoptosis after radiotherapy., 12th Int Congr Radiat Res., 2003

Analysis of cellular response by exposure to acute or chronic radiation in human lymphoblastoid TK-6 cells., 35th COSPAR., 2004

The p53 gene status and new p53-targeted therapies of chemical chaperones and high LET radiations for cancer., BAERI Symp., 2005

Radiation-induced p53-dependent and -independent apoptosis., 1st Asian Congr Radiat Res., 2005

Radioadaptive response by pre-irradiation at a low dose-rate., World Congr Nncl Med Biol., 2006

Analysis of mutations of the rpsL gene in E. coli, B. subtilis and S. cerevisiae following long-term space flight on Mir., COSPAR Coll Mutag Cons Space Environ., 2006

The biological function of radiation-induced nitric oxide radicals through Hdm2-p53 interaction., 13th Int Congr Radiat Res., 2007

Development of thermotolerance requires interaction between polymerase β and heat shock proteins., 12th Biennial Natl Conf Indian Associat Hyperthermia Oncol Med., 2008

Heat-induced DNA damage and signal transduction., 4th Int Congr Stress Resp Biol Med., 2009

Molecular chaperone therapy against human cancer cells., 4th Int Congr Stress Resp Biol Med., 2009

Cell growth, morphology and cell differentiation of Dictyostelium in space environment., Int Workshop Ultra-long-term Cryogenic Preserv Network Biol Environ Specimens., 1997

Gene expression of p53-regulated genes in mammalian cultured cells after exposure to space environment., 18th Ann NASA Space Radiat Invest Workshop., 2007

Possibility of synergism on biological effects of space radiations under microgravity environment., 1st Asian Congr Radiat Res., 2005

NHEJ pathway and low dose-rate effects (LDRE)., 1st Asian Congr Radiat Res., 2005

Radioadaptive response by pre-irradiation at a low dose-rate., 5th Jpn-France Workshop Radiobiol Med Imaging., 2004

Aim, preparation and fight in Rad Gene/LOH space experiments., 5th NIRS Int Open Lab Workshop., 2010

Reports of “Rad Gene”-space radiation effects on human cells-., 5th NIRS Int Open Lab Workshop., 2010

Gene expression analysis from human cultured cells frown in space., 5th NIRS Int Open Lab Workshop., 2010

Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture., 11th Int Conf Photobiol., 1992

Induction of wild p53 following γ-irradiation, ultraviolet ray exposure and hyperthermia in a human glioblastoma cell line A-7., 42nd Ann Meeting Radiat Res Society & 14th Ann Meeting North Am Hyperthermic Soci., 1994

p53-independent accumulation of WAF1 gene expression by heat., 10th Int Congr Radiat Res., 1995

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermo sensitivity and stimulates apoptosis by heat stress., 7th Int Congr Hyperthermic Oncol., 1996

Hyperthermic enhancement of tumor growth inhibition by accelerated carbon-ion in transplantable human esophageal cancer., NIRS Int Sem Heavy Charged Particle Therapy Cancer., 1997

CDDP induces p53-dependent apoptosis in tangue cancer cells., 1st World Congr Head Neck Oncol., 1998

Induction of p53-dependent signal transduction by low dose radiations and space environment in rats., 49th Int Astronaut Congr., 1998

Mutation induction in the rpsL gene on an E. coli-B. subtillis shuttle vector by space flight on MIR., 49th Int Astronaut Congr., 1998

Accumulation of a tumor suppressor p53 in rat muscle after a space flight., 32nd COSPAR., 1998

Accumulation of tumor suppressor p53 in rat muscle after space flight., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998

Cell growth, cell differentiation and morphology of Dictyostelium discoideum in space environment., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998

Tumor suppressor p53 response by low-dose-rate and chronic radiation., Natl Instit Radiol Sci Int Workshop., 1998

Accumulation of a tumor suppression p53 in rat muscle after a space flight., Ann Invest Workshop Space Radiat Res., 1998

Mutation induction by Mir flight in a bacterial rpsL shuttle vector., Ann Invest Workshop Space Radiat Res., 1998

Mutant p53 gene transfection enhanced radiation-induced radioresistance and G2 arrest in human cancer cells., 11th Int Congr Radiat Res., 1999

Detection of DNA damage induced by space radiations at Mir-space station and space shuttle by post-labeling of DNA., 11th Int Congr Radiat Res., 1999

Low-dose-rate radiation attenuates tumor suppressor p53 response., 11th Int Congr Radiat Res Sat Meeting Biol Effects Low Dose Radiat., 1999

Detection of DNA damage induced by space radiation in the MIR-station and space shuttle by post-labeling of DNA., 10th Ann Space Radiat Health Investigat Workshop., 1999

New strategy of cancer therapy: Restoration of mutant p53 to normal p53 function by glycerol as a chemical chaperone., 11th Int Congr Radiat Res., 1999

The effects of microgravity on ligase activity in DNA repair for double strand breaks., 10th Ann Space Radiat Health Investigat Workshop., 1999

Relationship between p53 status and amounts of hsp72 induction in human cancer cells., 60th Ann Meeting Soci Invest Dermatol., 1999

Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone., Int Forum Hyperthermia Osaka., 1999

Differentiation of Dictyostelium discoideum vegetative cells into spores during earth orbit in space., 33rd COSPAR., 2000

Alkylating agent (MNU)-induced mutation in space environment., 33rd COSPAR., 2000

The effects of microgravity on induced mutation in E. coli and S. cerevisiae cells., 33rd COSPAR., 2000

Low-dose and low dose rate radiation attenuates apoptosis through tumor suppressor p53 response., 1st Int Workshop Space Radiat., 2000

Tumor suppressor p53 response is blunted by low-dose-rate radiation., 10th Int Congr Int Radiat Protect Associat., 2000

Suppression of p53 and Bax accumulation after X-irradiation by small dose pre-irradiation in radioadaptive survival response of C57BL/6 mice., 10th Int Congr Int Radiat Protect Associat., 2000

Enzymatic chemical reaction under microgravity environment in space., Ann Int Gravitat Physiol Meeting., 2000

Unique postural control of upside-down swimming catfish, Synodontis nigriventris, not affected by the change of gravity., Ann Int Gravitat Physiol Meeting., 2000

The effect of microgravity on induced mutation through DNA synthesis during space flight., 22nd Int Symp Space Technol Sci., 2000

DNA-PK activity acts radioadaptation of apoptosis induced by pre-irradiation at a low-dose in mouse spleen., 52nd Int Astronaut Congr., 2001

Radiation-induced apoptosis in SCID mouse spleen after low-dose or low-dose rate irradiation., 2nd Int Coff Eff Low Very Low Doses Ionizing Radiat Human Health Word Council Nuclear Workers., 2001

Radiation-induced apoptosis in Scid mouse spleen after low-dose or low-dose rate irradiation., 12th Ann Space Radiat Health Investigat Workshop., 2001

Suppression of X-ray-induced apoptosis by low dose pre-irradiation in the spleen of C57BL/6 mice., Int Symp Radiat Homeostasis., 2001

Effect of pre-irradiation with X-ray to mice whole body on radiation-induced killing, induction of splenic lymphocyte apoptosis and gene expression of mutated in Ca2+ channel α1A subunit., Int Symp Radiat Homeostasis., 2001

New strategy of hyperthermic therapy: Combination with gene or molecular chaperone therapy., Godon Conf Radiat Therapy Cancer., 2001

Pre-irradiation with a low dose-rate depressed radiation-induced TcR gene mutation., Int Symp Biol Effects Low Dose Radiat., 2002

Enhanced radiation-induced fatal sensitivity and splenic lymphocyte apoptosis in mice with mutation in P/Q-type Ca2+ channel α1A subunit gene., Int Symp Biol Effects Low Dose Radiat., 2002

Analysis of radiosensitivity in human squamous cell carcinoma cells with different p53 genetic status using cDNA microarray., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002

Glycerol enhances CDDP-induced growth inhibition of mutant p53 tumors., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002

Radiation biology in space: DNA damage and biological effects of space radiation., 1st Asia Congr Photobiol., 2002

Effects of an HSP inhibitor, KNK437, on heat sensitivity and heat tolerance., 3rd Asia Congr Hypthermic Oncol., 2002

p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET., 3rd Asia Congr Hypthermic Oncol., 2002

Detection of DNA damage induced by space radiation in Mir and Space Shuttle., 2nd Int Workshop Space Radiat Res., 2002

Pre-irradiation at a low-dose-rate blunted tumor suppressor p53 response., 2nd Int Workshop Space Radiat Res., 2002

The effect of microgravity on induced mutation through DNA synthesis during space flight., 2nd Int Workshop Space Radiat Res., 2002

Radiation microbiology in space environment conducted using space shuttle and space station Mir., 2nd Int Workshop Space Radiat Res., 2002

Repair system for DNA damages in meiotic cells of Caenorhabditis elegans., 2nd Int Workshop Space Radiat Res., 2002

Radiation responses of survival and splenic lymphocyte apoptosis in rolling mouse Nagoya following low-dose pre-irradiation., 2nd Int Workshop Space Radiat Res., 2002

Radiation-induced gene expression about apoptosis-related genes by DNA array analysis., 2nd Int Workshop Space Radiat Res., 2002

The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae during space flight., 2nd Int Workshop Space Radiat Res., 2002

The effects of microgravity on ligase activity in DNA repair of double-strand breaks during space flight., 2nd Int Workshop Space Radiat Res., 2002

Differentiation of Dictyostelium discoideum during space flight., 2nd Int Workshop Space Radiat Res., 2002

Mutation frequency of plasmid DNA and Escherichia coli by long-term space flight on Mir., 2nd Int Workshop Space Radiat Res., 2002

Sensitization by glycerol for CDDP-therapy against mutant p53 tumors., 7th Japan-Taiwan Conf Otolaryngol Head Neck Surg., 2003

New p53-targeted cancer therapies combined with chemical or molecular chaperone., 1st Int Congr Stress Resp Biol Med., 2003

Gene expression after X-irradiation and/or glycerol in human anaplastic carcinoma cells harboring mutated p53 gene., 12th Int Congr Radiat Res., 2003

Pre-irradiation at a low dose-rate blunted p53 response., 12th Int Congr Radiat Res., 2003

Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene., 12th Int Congr Radiat Res., 2003

The mechanism of radiation adaptive response., Conf Recent Trend Radiat Biol., 2004

Glycerol restores radio-sensitivity of transplanted mp53 tumors., 6th Int Conf Head Neck Cancer., 2004

Expression of gene and protein after CDDP and/or glycerol treatment of mutated p53 cells., 6th Int Conf Head Neck Cancer., 2004

Dorsal light reflex is absent in the postural control system of the upside-down swimming catfish, Synodontis nigriventris., 35th COSPAR., 2004

Heat sensitization by inhibitors targeted for signaling factors of cellular survival., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004

Evidence for DSBs as a critical trigger of heat-induced cell killing., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004

High-LET radiation enhanced p53-independent apoptosis., 3rd Int Workshop Space Radiat., 2004

Effects of mild hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, referring to the effect on intratumor quiescent cells., 9th Int Congr Hyperthermic Oncol., 2004

DSB is the targets of cell killing induced by heat., 9th Int Congr Hyperthermic Oncol., 2004

Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53., 9th Int Congr Hyperthermic Oncol., 2004

Heat sensitizers-targeted for anti-apoptosis signal transduction pathways in human cultured cancer cells., 9th Int Congr Hyperthermic Oncol., 2004

Mediation of NBS1 to radiation-induced cellular survival signaling pathway via NF-κB., 1st Asian Congr Radiat Res., 2005

p53-independent enhancement of radiation sensitivity by siRNA targeted for NBS1 in human tongue cancer cells., 1st Asian Congr Radiat Res., 2005

Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 1st Asian Congr Radiat Res., 2005

Heat sensitization by PD98059, an inhibitor targeted for MAPK cascade., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006

Heat sensitization by targeting heat-induced cell survival signal transduction through Akt., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006

Apoptosis-related protein expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53 with protein microarray., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006

The role of polymerase β and HSPs on the thermo-tolerance., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006

Radioadaptive response by low or high LET-radiation., 36th COSPAR., 2006

Analysis of matrix proteins of otolith in upside-down catfish., 36th COSPAR., 2006

Phosphorylation of DNA damage-recognizing proteins at heavy-ion track., 36th COSPAR., 2006

Dynamics of DNA damage-recognizing proteins at heavy-ion-induced track., 4th Int Workshop Space Radiat Res., 2006

Review: Interaction of microgravity and space radiations., 27th Ann Int Gravit Phys Meeting., 2006

p53-independent heat sensitization of lung cancer cells by PD98059, an inhibitor targeting for MAPK cascade., 12th Congr Asian Pacific Soc Respirol., 2007

siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner., 13th Int Congr Radiat Res., 2007

Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 13th Int Congr Radiat Res., 2007

Spatio-temporal responses to different UV wavelengths in human skin organ culture., 13th Int Congr Radiat Res., 2007

High-LET radiations enhanced apoptosis regardless of p53 status., 13th Int Congr Radiat Res., 2007

Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks., 13th Int Congr Radiat Res., 2007

Preparation for ISS experiment; biological influences of space radiation and microgravity., 15th Int Acad Astron., 2007

Heat-induced DNA strand breaks and their repair., 8th ICHS Annual-Convention & 4th Biennel Natl Meet Int Associat Hyperthermic Oncol Med., 2007

The p53-dependent radioadaptive response., 37th COSPAR., 2008

Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with ？H2AX in the nucleus after heat treatment., Ataxia-Telangiectasia Workshop 2008., 2008

Hdm2 and NO radicals contribute to the p53-dependent radioadaptive response., Ataxia-Telangiectasia Workshop 2008., 2008

The study of target genes deciding heat-sensitivity., 10th Int Congr Hyperthermic Oncol., 2008

Development of thermotolerance requires interaction between polymerase β and heat shock protein., 10th Int Congr Hyperthermic Oncol., 2008

Tween80 enhances heat-induced arrest of cell proliferation through regulating Akt and NBS1 signaling pathways., 10th Int Congr Hyperthermic Oncol., 2008

A low dose pre-irradiation induces radio- and heat- resistance via HDM2 and NO radicals, and is associated with p53 functioning., Int Conf Radiat Damage Biomol Systems., 2009

DNA-DSB recognition proteins localize along heavy-ion induced tracks in the cell nucleus., Heavy Ions Ther Space Symp., 2009

The molecular mechanism of p53-dependent radioadaptive response by NO radicals., Heavy Ions Ther Space Symp., 2009

The molecular mechanism of radioadaptive response., 2nd Asian Congr Radiat Res., 2009

Cell death induced by high LET and low LET radiations., 2nd Asian Congr Radiat Res., 2009

NO radicals choreograph p53-different radio-sensitivity in human lung cancer cells., 2nd Asian Congr Radiat Res., 2009

Protein microarray analysis of apoptosis-related protein expression following heat shock in human toungue squamous cell carcinomas containing different p53 phenotypes., 2nd Asian Congr Radiat Res., 2009

The therapeutic target of DNA repair pathways against alkylating agents., 2nd Asian Congr Radiat Res., 2009

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity in lung cancer cells bearing different p53 gene status., 2nd Asian Congr Radiat Res., 2009

Formaldehyde-induced DNA damage and its repair., 2nd Asian Congr Radiat Res., 2009

Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells., 2nd Asian Congr Radiat Res., 2009

Space experiment “Rad Gene”-report 1; p53-Dependent gene expression in human cultured cells exposed to space environment., 38th COSPAR., 2010

Space experiment “Rad Gene”-report; Detection of DNA damage and adaptive response activity of human cells exposed to space radiations., 38th COSPAR., 2010

Cell lethality by carbon- Ion beams in X-ray resistant cells., 51st Ann Meeting of Particle Therapy Co-operative Group, 2012

Expression of genes and proteins in human cultured lymphoblastoid cells during spaceflight., 39th COSPAR, 2012

Recent advances in the biology of carbon-ion cancer therapy, KHIMA Seminar on Heavy-ion Radiotherapy, 2012

A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status., 11th Int Congr Hyperthermic Oncol., 2012

Heat treatment as well as X-ray-irradiation depresses gastric mucosal damage induced with restraint plus water-immersion stress through HSP-induction in mice., 11th Int Congr Hyperthermic Oncol., 2012

ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating., 11th Int Congr Hyperthermic Oncol., 2012

Hyperthermic sensitization efficacy as a target of homologous recombination repair pathways in the oral cancer cells., 11th Int Congr Hyperthermic Oncol., 2012

Space experiment of “Rad Gene” in ISS Kibo: Radiation effects in human cultured cells., 3rd Asian Congress of Radiation Research (ACRR2013)., 2013

LET-dependent biological effect of DNA DSB repair on cell killing., Ion Therapy and Space Radiation Symposium 2013 (HITSRS2013)., 2013

LET-dependent biological effect of DNA double-strand break repair on radiosensitivity., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013

Combination effect of carbon-ion beams and DNA repair inhibitor and/or cell cycle regulation inhibitor on cell killing in lung cancer cells., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013

Depression of p53-independent Akt survival signals in human oral cancer cells after exposure to high-LET radiation., Asian Congress of Radiation Research (ACRR2013)., 2013

Achievement of the first life science experiments in the Japanese Experimental Module "Kibo" of the ISS, The 28th International Symposium on Space Technology and Science, 2011

Long term stay against space radiation for human health, The 28th International Symposium on Space Technology and Science, 2011

FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ, ICRR 2011, 2011

Space radiation effects on human cultured cells in an International Space Station at Kibo module, ICRR 2011, 2011

NHEJ plays a more important role than HR in defining radiosensitivity after exposure to high-LET radiation, ICRR2015, 2015

Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells, SRHIT2015, 2015

Enhancement of heat sensitivity of human cancer cells by HR inhibitor B02 but not NHEJ inhibitor NU7026., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol, 2014

Research of biological effect by solar radiation using exposure area at ISS platform., 2014

Enhancement of heat sensitivity by depression of homologous recombination repair., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol., 2014

Increase in cell motility by C-ion irradiation and its inhibition by the ROCK inhibitor in lung adenocarcinoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53), 2014

Combination effect of carbon-ion beams and cell cycle regulation inhibitor on cell killing in lung cancer cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014

Relation between sensitivity to carbon-ion beams and expression of cancer stem cell marker in melanoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014

Enhancement of heat sensitivity of human cancer cells by inhibitor of HR but not NHEJ, ICHO2016, 2016

Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells, PTCOG56, 2017

Performance evaluation of new devices to synchronize X-ray or heavy-ion irradiation and simulated microgravity for space radiation research, ISTS2017, 2017

New devices to synchronize irradiation and simulated microgravity for space radiation research, ISSRPRT, 2017

Heat induces DNA double strand breaks under hypoxia, The 7th Asian Congress of Hyperthermic Oncology, 2018

Anti-tumor and anti-metastasis effects of carbon-ion radiotherapy combined with anti-CTLA4 antibody, PTCOG57, 2018

Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632., ICRR2015, 2015

Effect of DSB repair on cell killing by radiation with different LET values, 2015

Targeting carbon-ion beams-induced G2 checkpoint activation with the Wee-1 inhibitor MK-1775 in lung cancer cells, 2015

Depression of p53-independent Akt survival signals after high-LET radiation in mutated p53 cells, The 40th COSPAR Scientific Assembly, 2014

Stress proteins are induced by space environment, The 40th COSPAR Scientific Assembly, 2014

Development of 3D-clinostat synchronized heavy-ion irradiation system, Asian Microgravity Symposium 2016, 2016

RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences., 63rd Annual RRS Meeting, 2017

Development of 3D clinostat synchronized irradiation system for simulating space conditions., 2018 NASA Human Research Program Investigators' Workshop, 2018

15 Oct. 2020, 16 Oct. 2020, Japanese

15 Oct. 2020, 16 Oct. 2020, Japanese

15 Oct. 2020, 16 Oct. 2020, Japanese

15 Oct. 2020, 16 Oct. 2020, Japanese

07 Oct. 2020, Japanese

07 Oct. 2020, Japanese

07 Oct. 2020, Japanese, Japan, Domestic conference

15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference

15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference

15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference

Study on the preventive and therapeutic effects of melatonin on diseases caused by space: Analysis using fish scales on board a satellite, 21 Jan. 2025, 21 Jan. 2025, 22 Jan. 2025, Japanese

Future outlook for science for human planetary habitation in space, Akihisa Takahashi, 21 Jan. 2025, 21 Jan. 2025, 22 Jan. 2025, Japanese

10 Jan. 2025, 09 Jan. 2025, 10 Jan. 2025, Japanese

08 Dec. 2024, 07 Dec. 2024, 08 Dec. 2024, Japanese

07 Dec. 2024, 06 Dec. 2024, 07 Dec. 2024, Japanese

23 Nov. 2024, 23 Nov. 2024, 23 Nov. 2024, Japanese

17 Nov. 2024, 16 Nov. 2024, 17 Nov. 2024, Japanese

14 Nov. 2024, 14 Nov. 2024, 14 Nov. 2024, Japanese

08 Oct. 2024, 08 Oct. 2024, 08 Oct. 2024, Japanese

The Effect of Carbon Ion Ultra-high Dose Rate Irradiation on Proliferation in Mouse Osteosarcoma Cells, Hiromu Suda; Yukari Yoshida; Akihisa Takahashi; Tatsuya Ohno, 26 Sep. 2024, 25 Sep. 2024, 28 Sep. 2024, English

Biological effects of FLASH carbon-ion irradiation on normal tissues, Yukari Yoshida; Hiromu Suda; Wenteng Cao; Mutsumi Tashiro; Ken Yusa; Masao Nakao; Akihisa Takahashi; Tatsuya Ohno, 25 Sep. 2024, 25 Sep. 2024, 28 Sep. 2024, English

My research history for;Living in Space, Akihisa Takahashi, 2nd Korea-US Space Medicine Symposium, 25 Sep. 2024, 25 Sep. 2024, 25 Sep. 2024, English

20 Sep. 2024, 20 Sep. 2024, 23 Sep. 2024, Japanese

20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese

20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese

20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese

Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles, Shengli Zhang; Shenke Zhang; Zhen Wang; Takuya Adachi; Yukari Yoshida; Akihisa Takahashi, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, English

Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, English

19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese

Combined effects of radiation and simulated microgravity on intestinal tumorigeness in ApcMin/+ mice, Chizuru Tsuruoka; Kenshi Suzuki; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, COSPAR2024, 19 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English, Busan, Korea, Republic of, International conference

INCREASED CHROMOSOME ABERRATIONS IN HUMAN CELLS EXPOSED TO SIMULATED MICROGRAVITY AND RADIATION SIMULTANEOUSLY, Premkumar Saganti; Megumi Hada; Hiroko Ikeda; Ianik Plante; Jian-Hua Mao; Alexandros G. Georgakilas; Akihisa Takahashi; Ioannis Michalopoulos, COSPAR2024, 14 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English, Busan, Korea, Republic of, International conference

17 May 2024, 17 May 2024, 17 May 2024, Japanese, Japan, Domestic conference

Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, 17 May 2024, 17 May 2024, 17 May 2024, English, Maebashi, Japan, Domestic conference

17 May 2024, 17 May 2024, 17 May 2024, Japanese, Japan, Domestic conference

Analysis of FLASH effect with carbon-ion beams in vivo study, Yukari Yoshida; Hiromu Suda; Mutsumi Tashiro; Ken Yusa; Masao Nakao; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference

Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference

Biological response of cancer cells to carbon FLASH irradiation, Hiromu Suda; Yukari Yoshida; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference

Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference

Differential gene expression in human fibroblasts using a Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity change (SwiNG), Polina Malatesta; Konstantinos Kyriakidis; Megumi Hada; Hiroko Ikeda; Akihisa Takahashi; Premkumar Saganti; Alexandros Georgakilas; Ioannis Michalopoulos, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference

DIFFERENTIAL GENE EXPRESSION IN HUMAN FIBROBLASTS SIMULTANEOUSLY EXPOSED TO PARTIAL GRAVITY AND LOW DOSE-RATE NEUTRONS, P. Malatesta; K. Kyriakidis; M. Hada; H. Ikeda; A. Takahashi; P. B. Saganti; A. G. Georgakilas; I. Michalopoulos, NASA HRP meeting 2024, 16 Feb. 2024, English, Houston, United States, International conference

Study of melatonin as an effective therapeutic agent for various diseases in astronauts, Nobuo Suzuki; Jun Hirayama; Akihisa Takahashi; Kouhei Kuroda; Natsuno Yasuda; Yoshiaki Tabuchi; Yukihiro Furusawa; Mika Ikegame; Kazuki Watanabe; Yusuke Maruyama; Hajime Matsubara; Takayoshi Nakano; Hiromi Kimura-Suda; Ryotaro Kawamura; Hiroyuki Mishima; Haruyasu Kato; Azusa Seki; Atsuhiko Hattori, SUS38, 16 Jan. 2024, 16 Jan. 2024, 17 Jan. 2024, Japanese, Japan, Domestic conference

Biological Combined Effects of Simultaneous Exposure to Low-dose-rate Radiation and Partial Gravity Simulation the Moon, A.Takahashi; J-H Mao; P.B.Saganti; M,Hada, 7th GLOBAl MOON VILLAGE WORKSHOP＆ SYMPOSIUM, 07 Dec. 2023, 06 Dec. 2023, 10 Dec. 2023, English, Okayama, Tottori, Japan, International conference

01 Dec. 2023, 01 Dec. 2023, 01 Dec. 2023, Japanese, Japan, Domestic conference

24 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference

23 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese

24 Sep. 2023, 22 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference

Ground simulation experiment: Chromosome aberration frequencies due to space radiation exposure on the Moon and Mars, Akihisa Takahashi; Hiroko Ikeda; Jian-Hua Mao; Premkumar B. Saganti; Megumi Hada, ISRN2023, 04 Mar. 2023, English, Japan, Domestic conference

12 Feb. 2023, Japanese, Japan

Differential gene expression in human fibroblasts simultaneously exposed to radiation and simulated microgravity, P. Malatesta; H. Ikeda; A. Takahashi; M. Hada; A. G. Georgakilas; I. Michalopoulos, NASA HRP meeting2023, 09 Feb. 2023, English, Houston, United States, International conference

Chromosome aberration induction by simulation environment of outer space, Moon and Mars, Akihisa Takahashi; Hiroko Ikeda; Jian-Hua Mao; Premkumar B. Saganti; Megumi Hada, 2nd JSQMS meeting, 09 Dec. 2022, English, Japan, Domestic conference

Deep space and mitochondria, Akihisa Takahashi, JPW2022, 02 Dec. 2022, English, Japan, Domestic conference

FLASH carbon-ion irradiation~First report: construction of system and cultur ed cell experiments~, Yukari Yoshida; Mutsumi Tashiro; Takahiro Oike; Masao Nakao; Ken Yusa; Yuka Hirota; Akihisa Takahashi; Tatsuya Ohno, Nov. 2022, 10 Nov. 2022, 12 Nov. 2022, Japanese, Japan, Domestic conference

Expression profile of cell cycle / aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, H. Ikeda; M. Hada; A. Takahashi, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English, Houston, United States, International conference

The early proteomic responses of cultured mammalian cells exposed to simulated microgravity, Zhenlin Ju; Jing Wang; Megumi Hada; Akihisa Takahashi; Keigi Fujiwara, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English, Houston, United States, International conference

ncreases chromosome aberrations in human cells exposed simultaneously to simulated microgravity and neutron, M. Hada; H. Ikeda; P.B. Saganti; A. Takahashi, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English

Adenosine agonist treatment increases radioresistance in vitro and in vivo, Anggraeini Puspitasari; Matteo Cerri; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Martina Quartieri; Cristina Totis; Olga Sokol; Palma Simonello; Marco Durante; Walter Tinganelli, RRS2022, 17 Oct. 2022, 16 Oct. 2022, 19 Oct. 2022, English, Hawaii, United States, International conference

15 Oct. 2022, 15 Oct. 2022, 15 Oct. 2022, Japanese, Japan, Domestic conference

Adenosine Agonist treatment shows protective effects to C-ion irradiation, Anggraeini Puspitasari; Matteo Cerri; Fabio Squarcio; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Martina Quartieri; Cristina Totis; Palma Simonello; Marco Durante; Walter Tinganelli, ERRS2022, 21 Sep. 2022, 21 Sep. 2022, 24 Sep. 2022, English, Catania, Italy, International conference

Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons using SwiNG, Akihisa Takahashi; Hiroko Ikeda; Megumi Hada, Sep. 2022, 17 Sep. 2022, 18 Sep. 2022, Japanese

The synergistic effects of radiation and simulated microgravity to expression profile changes of cell cycle / aging-related genes in human fibroblasts, Hiroko Ikeda; Megumi Hada; Akihisa Takahashi, 16 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, Japanese, Osaka, Japan, Domestic conference

Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons simulating outer space, the Moon, and Mars, Akihisa Takahashi; Hiroko Ikeda; Megumi Hada, 15 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, English, Osaka, Japan, Domestic conference

First trial of cell experiments with FLASH carbon-ion irradiation, Yukari Yoshida; Mutsumi Tashiro; Takahiro Oike; Masao Nakao; Ken Yusa; Yuka Hirota; Akihisa Takahashi; Tatsuya Ohno, Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, Japanese, Osaka, Japan, Domestic conference

Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Akihisa Takahashi; Hiroko Ikeda; Nagy Lotfy Guiriuis; Yukari Yoshida; Fady; Megumi Hada, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference

Increases chromosome aberrations in human cells exposed to simulated microgravity and radiation simultaneously, M. Hada; H. Ikeda; J-H. Mao; P.B. Saganti; A. Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference

Expression profile of cell cycle or aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Hiroko Ikeda; Megumi Hada; Akihisa Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference

Evaluation of cancer risk in space simulated environment using APCMin / + mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Akihisa Takahashi; Shizuko Kakinuma, 44th COSPAR Scientific Assembly, 19 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference

24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese, Japan, Domestic conference

24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese, Japan, Domestic conference

Invitation to “space medicine”, Akihisa Takahashi, The 123rd scientific meeting of the Japan Society of Medical Physics (JSMP), 16 Apr. 2022, 14 Apr. 2022, 18 Apr. 2022, Japanese, Yokohama, Japan, Domestic conference

My future dream through "Living in Space", Akihisa Takahashi, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, English, Online, Japan, Domestic conference

Development of the Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Guirguis FNL; Yamanouchi S; Takeuchi K; Takahashi S; Tashiro M; Hidema J; Higashitani A; Adachi T; Zhang S; Yoshida Y; Nagamatsu A; Hada M; Takeuchi K; Takahashi T; Sekitomi Y; Takahashi A, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, English, Online, Japan, Domestic conference

Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector: Adaptation to Microgravity and Changes in Cell Motility., Zhenlin Ju; Yi-Jen Chiu; Tamlyn N. Thomas; Sakuya Yamanouchi; Yukari Yoshida; Jun-ichi Abe; Akihisa Takahashi; Jing Wang; Keigi Fujiwara; Megumi Hada, NASA HRP IWS meeting 2022, 10 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference

SwiNG: Combined-environment simulator of Moon and Mars, A. Takahashi; S. Yamanouchi; K. Takeuchi; S. Takahashi; M. Tashiro. Hidema; A. Higashitani; T. Adachi; S. Zhang; F.N.L. Guirguis; Y. Yoshida; A. Nagamatsu; M. Hada; K. Takeuchi; T. Takahashi; Y. Sekitomi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference

Comprehensive gene expression analysis of human fibroblasts using 3D clinostat synchronized irradiation systems, Hiroko Ikeda; Megumi Hada; Alkihisa Takahashi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference

Combined effects of space radiation and variable gravity -2021 Annual Report-, TAKAHASHI Akihisa; SUZUKI Kenshi; TSURUOKA Chizuru; MORIOKA Takamistu; TAKESHIMA Tsuguhide; YOSHIDA Yukari; NAKAMURA Asako; IKEDA Hiroko; HADA Megumi; NAGAMATSU Aiko; OHIRA Yoshinobu; INATOMI Yuko; KAKINUMA Shizuko, 18 Jan. 2022, 18 Jan. 2022, 19 Jan. 2022, Japanese, Japan, Domestic conference

Increased Chromosome Aberrations in Human Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Sakuya Yamanouchi; Jian Hua Mao; Hiroko Ikeda; Ianik Plante; Premkumar Saganti; Akihisa Takahashi, 2021 American Society for Gravitational and Space Research, 03 Nov. 2021, 03 Nov. 2021, 06 Nov. 2021, English, United States, International conference

Radiation protection effect of Synthetic hibernation following Carbon ion irradiation, Anggraeini Puspitasari; Fabio Squarcio; Matteo Cerri; Akihisa Takahashi; Kenji Hanamura; Yukari Yoshida; Tomoko Yakou; Tomoaki Shirao; Palma Simoniello; Cristina Totis; Julius Oppermann; Walter Tinganelli; Marco Durante, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, 03 Oct. 2021, 06 Oct. 2021, English, Puerto Rico, International conference

Biological effects of proton and carbon ions dual exposure in human fibroblasts, Hada M; Oizumi T; Nakamura A.J; Hirayama R; Takahashi A; Saganti P, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, English, International conference

The increases of chromosome aberration in human peripheral blood lymphocytes exposed to simulated microgravity and radiation simultaneously, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, 30 Sep. 2021, English

Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with a partial gravity environment, Shenke Zhang; Daishin Ueno; Takashi Ohira; Hisashi Kato; Tetsuya Izawa; Sakuya Yamanouchi; Yukari Yoshida; Akihisa Takahashi; Yoshinobu Ohira, 30 Sep. 2021, English

24 Sep. 2021, 24 Sep. 2021, 26 Sep. 2021, Japanese, Domestic conference

25 Sep. 2021, Japanese

Recent findings on the relative biological effectiveness (RBE) for deterministic effects, Hiroshi YASUDA; Yukari YOSHIDA; Bing WANG; Kento NAGATA; Arifumi HASEGAWA; Akihisa TAKAHASHI, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, Japanese, Domestic conference

Chromosome aberrations in human peripheral blood lymphocytes exposed simultaneously to radiation and simulated microgravity, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, English, Domestic conference

Synthetic hibernation and radioprotection, A. Puspitasari; M. Cerri; T. Hitrec; F. Squarcio; P. Simoniello; C. Totis; J. Oppermann; A. Takahashi; K. Hanamura; Y. Yoshida; T. Yakou; T. Shirao; M. Durante; W. Tinganelli, Italian Society for Radiation Research, 10 Sep. 2021, English, Italy, International conference

04 Jun. 2021, Japanese, Domestic conference

06 Feb. 2021, 06 Feb. 2021, 06 Feb. 2021, Japanese, Japan, Domestic conference

Increased chromosome aberrations in human cells exposed simultaneously to simulated microgravity and radiationIncreased chromosome aberrations in human cells exposed simultaneously to simulated microg, Megumi Hada; Sakuya Yamanouchi; Jordan Rhone; Jian-Hua Mao; Hiroko Ikeda; Ianik Plante; Keigi Fujiwara; Premkumar Saganti; Akihisa Takahashi, NASA HRP-IWS, 03 Feb. 2021, English, United States, International conference

Combined effects of radiation and simulated microgravity on decreased locomotor activity in the normal mouse brain, Yukari Yoshida; David Fernandez-Quezada; Sonia Luquin; de Anda; Akihisa Takahashi; Araceli Espinosa-Jeffrey, 43rd COSPAR, 02 Feb. 2021, English, Australia, International conference

Dose cancer progress in space?, Akihisa Takahashi, 43rd COSPAR, 02 Feb. 2021, English, Australia, International conference

Research on Combined Effects of Space Radiation and Variable Gravity – 2020 Annual Report-, TAKAHASHI Akihisa; SUZUKI Kenshi; TSURUOKA Chizuru; MORIOKA Takamistu; TAKESHIMA Tsuguhide; YOSHIDA Yukari; NAKAMURA Asako; IKEDA Hiroko; HADA Megumi; NAGAMATSU Aiko; OHIRA Yoshinobu; INATOMI Yuko; KAKINUMA Shizuko, 19 Jan. 2021, Japanese, Japan, Domestic conference

22 Jan. 2025, 21 Jan. 2025, 22 Jan. 2025, Japanese

28 Nov. 2024, 27 Nov. 2024, 29 Nov. 2024, Japanese

One of the Most Valued Reviewers from 2021 (LSSR), Akihisa Takahashi, One of the Most Valued Reviewers from 2021 (LSSR), Elsevier, Mar. 2022, Official journal

2002

1980

Young Investigator Award from Japanese Association of Space Biology Science, 1998

Incentive Award from Japanese Association of Radiation Research Society, 2001

Young Investigator Award from International Association for the Sensitization of Cancer Treatment, 2000

Young Investigator Award from Radiation Effects Association, 2008

ICRR2015 Excellent Poster Award, 2015

Association Award, International Association for the Sensitization of Cancer Treatment, 2009

Abe Award, Japanese Society of Thermal Medicine, 2009

2013

2013

Excellent Award of the 41st Japan Health & Research Institute, 2016

Scientific Dream Award of The 6th International Society of Radiation Neurobiology Conference, 2016

The Prize of The Japanese Society for Biological Sciences in, 2016

2005

2005

2010

One of the Most Valued Reviewers from 2019 (LSSR), Akihisa Takahashi, Elsevier, Aug. 2020

Cancer progression under microgravity environment in space, Akihisa Takahashi, Japan Space Forum, 01 Apr. 2019, 31 Mar. 2022

Combined effects of simulated microgravity and space radiation on human cells, Prairie View A & M University, Researcher, 28 Jul. 2017, 28 Jul. 2022, Principal investigator

06 Sep. 2017, 31 Mar. 2022, Principal investigator

07 Jul. 2017, 31 Mar. 2023, Principal investigator

05 Sep. 2019, 31 Mar. 2022, Principal investigator

2015, 2019, Competitive research funding, rm:published_papers

Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates, 髙橋昭久; 重粒子線医学推進機構, 新学術領域研究(研究領域提案型), 2015, 2019, Principal investigator, Competitive research funding, rm:published_papers

Apr. 2019, Mar. 2025, Principal investigator, Competitive research funding, rm:published_papers

Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2019, Mar. 2022, Principal investigator, Competitive research funding

2017, 2019, Competitive research funding

2016, 2018, Principal investigator, Competitive research funding

Apr. 2019, Mar. 2022, Principal investigator, Competitive research funding

2000, 2004, Competitive research funding

Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer, 太田 一郎; 奈; 医学部, 基盤研究(C), 2014, 2016, Competitive research funding

Selection of DSBs repair pathways in heat-induced cell death mediated by BRCA2, 梶原 淳久; 奈; 医学部; 研究員, 基盤研究(C), 2014, 2016, Competitive research funding

Elucidation of the suppression mechanism to activation of cancer stem cells by hyperthermia, 高橋 昭久; 先端科学研究指導者育成ユニット, 基盤研究(B), 2011, 2013, Competitive research funding

Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer, 太田 一郎; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(C), Grant-in-Aid for Scientific Research (C), Nara Medical University, 2011, 2013, In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer., Competitive research funding, 23592537, kaken

Elucidation of the radio-sensitization mechanism by heat, 高橋 昭久; 先端科学研究指導者育成ユニッ ト, Japan Society for the Promotion of Science, 挑戦的萌芽研究, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 2010, 2012, We already proposed the formation of DNA double-strand breaks (DSBs) by heat-treatment. Here we found that the HR-deficient cells were sensitive, and were low efficiency of DSB repair by heat when compared to the NHEJ-deficient cells and their parental cells. In addition, we demonstrated that heat-induced DSBs were repaired by HR. Our novel findings suggest that the HR exerts an importantrole in the radio-sensitization mechanism by heat., Competitive research funding, 22659224, kaken

Mechanism of Radioadaptation, 大西 武雄; 奈; 医学部; 特任教授, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2009, 2011, The aim of this study was to examine biological effects of nitric oxide(NO) on radioadaptation such as the induction of radioresistance and the depression of chromosomal aberration from the cell cycle phase and p53 gene status in human cancer cells. This radioadaptation effect was observed during a clearly shortened G_2/M phase and a slightly prolonged S phase. By pre-irradiation with low dose or mild-heat treatment, we found that water-immersion stress(RWIS)-induced stomach ulcer and apoptosis in stomach cells were depressed though the induction of heat shock proteins. To clarify the biological effects of space environment, especially space radiations, a space experiment of "Rad Gene" was performed as the first life experiment with two human lymphoblastoid cell lines bearing wild-type p53 gene(wtp53) and mutated p53 gene mp53 in an International Space Station(ISS) for 133 days. The space flown cells at frozen state were cultured and then exposed to challenging X-ray-irradiation. All of the radioadaptive responses of cell killing, apoptosis, chromosomal aberrations and mutations were found only in wtp53 cells, but not in the mp53 cells., Competitive research funding, 21310040, kaken

2009, 2010, Competitive research funding

Analysis of cell nuclear dynamics in thermotolerance development, 高橋 昭久; 先端科学研究指導者育成ユニット, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2008, 2010, After heat treatment at 45.5℃ for 20 min, DNA DSB recognizing proteins were partially localized with γH2AX foci. Here we show that there were slight differences in the localization pattern among these proteins, such as a disappearance from the nucleus (phospho-ATM) and translocation to the cytoplasm (phospho-NBS1) at 30 min after heat treatment, and some foci (phospho- DNA-PKcs and phospho-Chk2) appeared at 8 h after heat treatment. In addition, we demonstrated that not NHEJ deficient cells but HR deficient cells is heat-sensitivity compared with these proficient cells. Polβ functions as a critical elements involved in thermotolerance. Moreover, we indicated that heat-induced foci of γH2AX and these DNA DSB recognizing proteins were suppressed in thermotolerance development., Competitive research funding, 20390330, kaken

Effect of mTOR inhibitors on radiation sensitivity of head and neck cancer cells, 太田 一郎; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(C), Grant-in-Aid for Scientific Research (C), Nara Medical University, 2008, 2010, A high extent of activation of the PI3K/Akt pathway is involved in head and neck cancer therapeutic resistance, including radiotherapy and chemotherapy. The aim of this study was to examine whether the effect of rapamycin, an inhibitor of mTOR, on chemo- and radio-sensitivity is affected in human head and neck cancer cells. Rapamycin could enhance the effect of radiation and cisplatin through the repression of pro-survival signals, including PI3K/Akt pathway, and the reduction in the apoptotic threshold., Competitive research funding, 20592025, kaken

A study of the Heavy-ion beams medical treatment on the oral cancer, 桐田 忠昭; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2006, 2008, Competitive research funding, 18390546, kaken

2006, 2007, Competitive research funding

To clarify of the mechanism of thermotolerance, 高橋 昭久; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2006, 2007, Although heat shock proteins (HSPs) are well known to contribute to thermotolerance, they only play a supporting role in the phenomenon. Recently, it has been reported that heat sensitivity depends on heat-induced DNA double-strand breaks (DSBs), and thermotolerance also depends on the suppression of DSB formation. However the critical elements involved in thermotolerance have not yet been fully identified. Heat produces DSBs and leads to cell death through denaturation and dysfunction of heat-labile repair proteins such as DNA polymerase β (Polβ). Here we show that thermotolerance was partially suppressed in Polβ-/- mouse embryonic fibroblasts (MEFs) when compared to the wild type MEFs, and was also suppressed in the presence of the HSP inhibitor, KNK437, in both cell lines. Moreover, we found that heat-induced γH2AX was suppressed in the thermotolerant cells. These results suggest that Polβ at least contributes to thermotolerance through its reactivation and stimulation by Hsp27 and Hsp70. In addition, it appears possible that fewer DSBs were formed after a challenging heat exposure because pre-heat-induced Hsp27 and Hsp70 can rescue or restore other, as yet unidentified, heat-labile proteins besides Polβ. Our novel findings provide strong evidence that Polβ functions as a critical element involved in thermotolerance and exerts an important role in heat-induced DSBs., Competitive research funding, 18390335, kaken

Regulation of radiation-induced apoptosis targeting signal transduction factors, 大西 武雄; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(A), Grant-in-Aid for Scientific Research (A), Nara Medical University, 2005, 2007, To develop more efficient regimens for various malignant tumors the attention has focused on searching for substances to sensitize cell lethality of tumors by radiation. Inhibitors against anti-apoptosis and/or cellular Proliferation signal transductions are as good candidates for enhancers of radiation Sensitivity on human cancer calls This study examined whether siRNAs or chemical inhibitors targeting key factors (NBS1, XIAP, P13-K, MAPK, Akt and heat proteins) in DNA repair and survival Signal transductions for anti-apoptosis and/or cellular, proliferation after radiation enhance radiation induced apoptosis, Further, it was examined whether; heavy-ion bin effectively, induce apoptosis p53 independently. We analyzed radiation/heat sensitivity apoptosis with colony formation assay, Western blot, fluorescent immuno-cytochemistry, arid hoechst staining using wild-type p53 or mutated p53 gene-transfected human lung and tongue cancer cells. We showed siRNAs targeting NBS1 and XIAP enhanced radiation sensitivity more efficiently in mutated p53 cells than the wild-type p53 cell Furthermore, LY294002 (inhibitor of PI3-K) enhanced radiation/heat sensitivity and radiation/heat-induced apoptosis p53 independently. PD98059 (inhibitor of MEK) and-SB203580 (inhibitor of p38) enhanced heat sensitivity but not radiation Sensitivity, Heavy-ion beams induced p53 independent apoptosis. Our results suggest that these siRNAs, chemical inhibitors and heavy-ion beams might contribute to high curative efficiency in radiation/heat cancer therapy for malignant cancer leading to enhanced, p53 independent radiation/heat sensitivity., Competitive research funding, 17201015, kaken

2004, 2005, Competitive research funding

Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks, 内海 博司; 体質研究会; 主任研究員, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Health Research Foundation, 2004, 2006, Introduction : In general, the dose rate of sparsely ionizing radiation is reduced over a period of time the biological effect of a given total dose is reduced. This low dose-rate effects (LDRE) has been generally accepted to result from the sub-lethal damage (SLD) recovery. To study the molecular mechanism of LDRE, we analyzed the knock-out mutants KU70^<-/->, RAD54^<-/->, and KU70^<-/->/RAD541^<-/->of the chicken B-cell line, DT40 (Cell (1997) 89:185-193,EMBO J (1998) 17:5497-5508), since our recent studies on SLD recovery, using these DT40 cells showed that the recovery of SLD is due to DSB repair mediated by homologous recombination (HR) (Radiat.Res (2001) 155,680-686). Materials and Methods : Our results were obtained with these knockout mutant clones of DT40. The length of cell cycle is almost the same,〜8 h, between the four types of cells. LDR radiation was delivered at under 1Gy/day using a ^<137>Cs g-ray source (Sangyo Kagaku Co., Ltd., Tokyo) at the RBC, Kyoto University. Cells were irradiated in suspension continuously at 39.5℃ in an incubator set in front of the ^<137>Cs source. Subsequently, serially diluted cells were inoculated into several individual culture dishes (Iwaki, Japan) containing 6 ml of 1.5% (w/v) methylcellulose (Aldrich, Milwaukee, WI) containing D-MEM/F-12 (Gibco-BRL), 15% FCS, 1.5% chicken serum and 10mM b-mercaptoethanol for each radiation dose. The cells were allowed to grow for 7 days. Results and Discussions : Survival enhancement by LDR irradiation was observed in parent DT40 and RAD54^<-/-> cells but not in non-homologous end-joining (NHEJ) deficient KU70^<-/-> and KU70^<-/->/RAD54^<-/-> cells. Under continuous LDR irradiation, NHEJ-deficient cells will be irradiated in G1 phase and killed since there is no repair system of DSBs in G1 phase. In LDRE, NHEJ pathway shall be more important than HR pathway because NHEJ pathway is working in whole cell cycle. We studied further LDRE using the deficient KU70^<-/-> and KU70^<-/->/53BP1^<-/-> cells since 53BP1 is reported to play a role in new NHEJ repair (Genes to Cells (2006) 11:935-948). KU70^<-/->/53BP1^<-/-> cells were sensitive than KU70^<-/-> cells under 1 Gy/day dose rate irradiation. These results suggest that 53BP1 play a role in a pathway distinct form Ku-dependent NHEJ pathways, and that both NHEJ pathway is important for LDRE., Competitive research funding, 16310040, kaken

2002, 2003, Competitive research funding

2000, 2001, Competitive research funding

2011, 2015, Competitive research funding

Elucidation of molecular mechanisms for radiation-induced cellular responses, JST Target Oriented Research for Embryonic Science and Technology (TOREST), 2011, 2015, Competitive research funding

Biological effect of space radiation, Grant-in-Aid for Scientific Research, 2015, Competitive research funding

26 Mar. 2018, 31 Mar. 2022, Principal investigator

01 Apr. 2019, 31 Mar. 2022, Principal investigator

01 Apr. 2017, 31 Mar. 2018, Principal investigator

Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2021, Mar. 2022, Principal investigator, Competitive research funding

Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2020, Mar. 2021, Principal investigator, Competitive research funding

01 Apr. 2022, 31 Mar. 2025, 23K24402, kaken

01 Apr. 2022, 31 Mar. 2025, 22H03143, kaken

01 Apr. 2020, 31 Mar. 2023, 20K09718, kaken