Researcher Profile and Settings

Researcher

• Name

  JINDE Seichiro

Profile and Settings

• Name

  Jinde, Seiichiro

Affiliation

• Gunma University, Graduate School of Medicine, Professor

Degree

• Mar. 2004

Research Experience

• Nov. 2024, 9999, Gunma University, Graduate School of Medicine Psychiatry and Neuroscience, Professor, Prof lv
• Dec. 2016, Oct. 2024, The University of Tokyo, Neuroscience, Graduate School of Medicine, Associate prof lecturer lv
• Jan. 2009, Oct. 2024, The Univ of Tokyo
• May 2010, Nov. 2016, The University of Tokyo, Faculty of Medicine University Hospital, Department of Neurology and Psychiatry, Associate prof lecturer lv
• Jan. 2009, May 2010, The University of Tokyo, Faculty of Medicine University Hospital, Department of Neurology and Psychiatry, Assistant prof lv
• Oct. 2005, Dec. 2008, UGCB/NIMH/NIH, visiting post-doc fellow
• Apr. 2004, Sep. 2005, The University of Tokyo, Faculty of Medicine University Hospital, Department of Neurology and Psychiatry, Research assistance
• Apr. 2000, Mar. 2004, The University of Tokyo, Neuroscience, Graduate School of Medicine, Others
• Apr. 1997, Mar. 2000
• Jun. 1996, Mar. 1997, Shiga University of Medical Science, University Hospital

Research Activities

Research Areas

• Life sciences, Psychiatry

Published Papers

• Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism., Zhilei Zhao; Naohiro Okada; Sho Yagishita; Noriaki Yahata; Nobuhiro Nitta; Sayaka Shibata; Yoshifumi Abe; Susumu Morita; Eureka Kumagai; Kenji F Tanaka; Tetsuya Suhara; Toru Takumi; Kiyoto Kasai; Seiichiro Jinde, Aug. 2024, Neuroscience Research, Scientific journal

  DOI
• Lower plasma betaine levels in men at clinical high risk for psychosis: Findings from a metabolomics investigation., Tatsuro Asai; Tempei Ikegame; Yoshihiro Satomura; Eureka Kumagai; Takuto Minami; Susumu Morita; Masahiro Kiyota; Eimu Shoji; Zhilei Zhao; Akiko Kanehara; Mariko Tada; Naohiro Okada; Shinsuke Koike; Miki Bundo; Kazuya Iwamoto; Kiyoto Kasai; Seiichiro Jinde, 27 Jul. 2024, Schizophrenia research, 271, 281, 282

  DOI
• Physical and psychosocial factors associated with fatigue in individuals with 22q11.2 deletion syndrome, Yusuke Takahashi; Yutaka Sawai; Akito Uno; Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Ichiro Sakamoto; Sho Yagishita; Seiichiro Jinde; Kiyoto Kasai, 07 Jun. 2024, Psychiatry and Clinical Neurosciences Reports, 3, 2, Scientific journal

  DOI
• Relationship between high trait anxiety in 22q11.2 deletion syndrome and the difficulties in medical, welfare, and educational services, Naomi Nakajima; Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Noriko Ohkouchi; Junko Hamada; Tomoko Ogawa; Hidetaka Tamune; Mutsumi Nakahara; Shunsuke Mori; Kayo Ichihashi; Seiichiro Jinde; Yukiko Kano; Ichiro Sakamoto; Kyoko Tanaka; Yoichiro Hirata; Hirofumi Ohashi; Tokuko Shinohara; Kiyoto Kasai, 13 Feb. 2023, Psychiatry and Clinical Neurosciences Reports, 2, 1, Scientific journal

  DOI
• Educational challenges for 22q11.2 deletion syndrome in Japan: Findings from a mixed methods survey., Miho Tanaka; Akiko Kanehara; Ryo Morishima; Yousuke Kumakura; Noriko Okouchi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Hidetaka Tamune; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kiyoto Kasai, 13 Feb. 2023, Journal of applied research in intellectual disabilities : JARID, 36, 3, 558, 570, Scientific journal

  DOI
• 22q11.2欠失症候群における身体疾患・神経疾患・知的障害の多疾病罹患と生活の質の関連の検証, Ryo Morishima; Hayato Yamana; Seiichiro Jinde; Yousuke Kumakura; Akiko Kanehara; Miho Tanaka; Taisuke Jo; Nobuaki Michihata; Kiyoto Kasai, 2023, Iryo To Shakai, Scientific journal

  DOI
• Retrospective chart review‐based assessment scale for adverse childhood events and experiences, Mika Yamagishi; Yoshihiro Satomura; Hanako Sakurada; Akiko Kanehara; Eisuke Sakakibara; Naohiro Okada; Shinsuke Koike; Sho Yagishita; Kayo Ichihashi; Shinsuke Kondo; Seiichiro Jinde; Masato Fukuda; Kiyoto Kasai, 17 Nov. 2022, Psychiatry and Clinical Neurosciences Reports, 1, 4, Scientific journal

  DOI
• Betaine supplementation improves positive symptoms in schizophrenia., Kenji Kirihara; Mao Fujioka; Motomu Suga; Shinsuke Kondo; Kayo Ichihashi; Daisuke Koshiyama; Kentaro Morita; Tempei Ikegame; Mariko Tada; Tsuyoshi Araki; Seiichiro Jinde; Kazuki Taniguchi; Taiga Hosokawa; Kazuyuki Sugishita; Shinjiro Dogan; Kohei Marumo; Masanari Itokawa; Kiyoto Kasai, 16 Nov. 2022, Schizophrenia research, 250, 120, 122

  DOI
• Children with special health care needs and mothers' anxiety/depression: Findings from the Tokyo Teen Cohort study, Namiko Kaji; Shuntaro Ando; Atsushi Nishida; Syudo Yamasaki; Hitoshi Kuwabara; Akiko Kanehara; Yoshihiro Satomura; Seiichiro Jinde; Yukiko Kano; Mariko Hiraiwa‐Hasegawa; Takashi Igarashi; Kiyoto Kasai, Dec. 2021, Psychiatry and Clinical Neurosciences, 75, 12, 394, 400, Scientific journal

  DOI
• Medical, welfare, and educational challenges and psychological distress in parents caring for an individual with 22q11.2 deletion syndrome: A cross-sectional survey in Japan., Ryo Morishima; Yousuke Kumakura; Satoshi Usami; Akiko Kanehara; Miho Tanaka; Noriko Okochi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Shuntaro Ando; Hidetaka Tamune; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kyoko Tanaka; Yoichiro Hirata; Akira Oka; Kiyoto Kasai, 03 Sep. 2021, American journal of medical genetics. Part A, 188, 1, 37, 45, Scientific journal

  DOI
• AKR1A1 Variant Associated With Schizophrenia Causes Exon Skipping, Leading to Loss of Enzymatic Activity., Kyoka Iino; Kazuya Toriumi; Riko Agarie; Mitsuhiro Miyashita; Kazuhiro Suzuki; Yasue Horiuchi; Kazuhiro Niizato; Kenichi Oshima; Atsushi Imai; Yukihiro Nagase; Itaru Kushima; Shinsuke Koike; Tempei Ikegame; Seiichiro Jinde; Eiichiro Nagata; Shinsuke Washizuka; Toshio Miyata; Shunya Takizawa; Ryota Hashimoto; Kiyoto Kasai; Norio Ozaki; Masanari Itokawa; Makoto Arai, 2021, Frontiers in genetics, 12, 762999, 762999, Scientific journal

  DOI
• Toward co-production of research in 22q11.2 deletion syndrome: Research needs from the caregiver's perspective., Hidetaka Tamune; Yousuke Kumakura; Ryo Morishima; Akiko Kanehara; Miho Tanaka; Noriko Okochi; Naomi Nakajima; Junko Hamada; Tomoko Ogawa; Mutsumi Nakahara; Seiichiro Jinde; Yukiko Kano; Kyoko Tanaka; Yoichiro Hirata; Akira Oka; Kiyoto Kasai, Nov. 2020, Psychiatry and clinical neurosciences, 74, 11, 626, 627

  DOI
• Social withdrawal and testosterone levels in early adolescent boys, Hayashi N; Ando A; Jinde S; Fujikawa S; Okada N; Toriyama R; Masaoka M; Sugiyama H; Shirakawa T; Yagi T; Morita M; Morishima R; Kiyono T; Yamasaki S; Nishida A; Kasai K, Jan. 2020, Psychoneuroendocrinology, in press
• 気分障害患者における病前および現在IQの臨床的意義 両者の一致度と主観的QOLとの関連の検討, 山岸 美香; 櫻田 華子; 金原 明子; 岡村 由美子; 里村 嘉弘; 榊原 英輔; 松岡 潤; 岡田 直大; 小池 進介; 神出 誠一郎; 近藤 伸介; 笠井 清登, Dec. 2019, 61, 12, 1469, 1478
• Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes., Zhilei Zhao; Seiichiro Jinde; Shinsuke Koike; Mariko Tada; Yoshihiro Satomura; Akane Yoshikawa; Yukika Nishimura; Ryu Takizawa; Akihide Kinoshita; Eisuke Sakakibara; Hanako Sakurada; Mika Yamagishi; Fumichika Nishimura; Aya Inai; Masaki Nishioka; Yosuke Eriguchi; Tsuyoshi Araki; Atsuhiko Takaya; Chiemi Kan; Maki Umeda; Akihito Shimazu; Hideki Hashimoto; Miki Bundo; Kazuya Iwamoto; Chihiro Kakiuchi; Kiyoto Kasai, 11 Nov. 2019, Translational psychiatry, 9, 1, 289, 289

  DOI
• Evaluation of the usefulness of saliva for DNA methylation analysis in cohort studies., Yui Murata; Ayaka Fujii; Sho Kanata; Shinya Fujikawa; Tempei Ikegame; Yutaka Nakachi; Zhilei Zhao; Seiichiro Jinde; Kiyoto Kasai; Miki Bundo; Kazuya Iwamoto, Aug. 2019, Neuropsychopharmacology reports, ahead of prints, Scientific journal

  DOI
• Auditory Steady State Response; nature and utility as a translational science tool., Kozono N; Honda S; Tada M; Kirihara K; Zhao Z; Jinde S; Uka T; Yamada H; Matsumoto M; Kasai K; Mihara T, Jun. 2019, Scientific reports, 9, 1, 8454, Scientific journal

  DOI
• Population-neuroscience study of the Tokyo TEEN Cohort (pn-TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development., Naohiro Okada; Shuntaro Ando; Motoyuki Sanada; Sachiko Hirata-Mogi; Yudai Iijima; Hiroshi Sugiyama; Toru Shirakawa; Mika Yamagishi; Akiko Kanehara; Masaya Morita; Tomoko Yagi; Noriyuki Hayashi; Daisuke Koshiyama; Kentaro Morita; Kingo Sawada; Tempei Ikegame; Noriko Sugimoto; Rie Toriyama; Mio Masaoka; Shinya Fujikawa; Sho Kanata; Mariko Tada; Kenji Kirihara; Noriaki Yahata; Tsuyoshi Araki; Seiichiro Jinde; Yukiko Kano; Shinsuke Koike; Kaori Endo; Syudo Yamasaki; Atsushi Nishida; Mariko Hiraiwa-Hasegawa; Miki Bundo; Kazuya Iwamoto; Saori C Tanaka; Kiyoto Kasai, May 2019, Psychiatry and clinical neurosciences, 73, 5, 231, 242, Scientific journal

  DOI
• 気分障害患者におけるWAIS-III成人知能検査簡易実施法の有用性の検討, 櫻田 華子; 山岸 美香; 金原 明子; 岡村 由美子; 里村 嘉弘; 榊原 英輔; 松岡 潤; 岡田 直大; 小池 進介; 神出 誠一郎; 近藤 伸介; 笠井 清登, Feb. 2019, 61, 2, 213, 217
• Integrated support for children with special health care needs reached AYA generation and their families, Yosuke Kumakura; Junko Hamada; Tomoko Ogawa; Hidetaka Tamune; Akiko Kanehara; Ryo Morishima; Noriko Okouchi; Naomi Nakajima; Tempei Ikegame; Kentaro Morita; Kenji Kirihara; Kayo Ichihashi; Seiichiro Jinde; Yukiko Kano; Kiyoto Kasai, Jan. 2019, Wage & social security, 1721, 1721・1722, 12, 31, Scientific journal
• Severity-dependent and -independent brain regions of major depressive disorder: A long-term longitudinal near-infrared spectroscopy study., Satomura Y; Sakakibara E; Takizawa R; Koike S; Nishimura Y; Sakurada H; Yamagishi M; Shimojo C; Kawasaki S; Okada N; Matsuoka J; Kinoshita A; Jinde S; Kondo S; Kasai K, Jan. 2019, Journal of affective disorders, 243, 249, 254, Scientific journal

  DOI
• Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus), Junko Ueda; Yui Murata; Miki Bundo; Arata Oh-Nishi; Hidetoshi Kassai; Tempel Ikegame; Zhilei Zhao; Seiichiro Jinde; Atsu Aiba; Tetsuya Suhara; Kiyoto Kasai; Tadafumi Kato; Kazuya Iwamoto, Jul. 2017, NEUROSCIENCE RESEARCH, 120, 60, 65, Scientific journal

  DOI
• Extracellular elevation of adrenomedullin, a gene associated with schizophrenia, suppresses heat shock protein 1A/1B mRNA, Zhilei Zhao; Seiichiro Jinde; Chihiro Kakiuchi; Kiyoto Kasai, Dec. 2016, NEUROREPORT, 27, 18, 1312, 1316, Scientific journal

  DOI
• Mismatch negativity as a "translatable" brain marker toward early intervention for psychosis: a review., Tatsuya Nagai; Mariko Tada; Kenji Kirihara; Tsuyoshi Araki; Seiichiro Jinde; Kiyoto Kasai, 23 Sep. 2013, Frontiers in psychiatry, 4, 115, 115, Scientific journal

  DOI
• GluN2B in corticostriatal circuits governs choice learning and choice shifting, Jonathan L. Brigman; Rachel A. Daut; Tara Wright; Ozge Gunduz-Cinar; Carolyn Graybeal; Margaret I. Davis; Zhihong Jiang; Lisa M. Saksida; Seiichiro Jinde; Matthew Pease; Timothy J. Bussey; David M. Lovinger; Kazu Nakazawa; Andrew Holmes, Aug. 2013, NATURE NEUROSCIENCE, 16, 8, 1101, U176, Scientific journal

  DOI
• Hilar mossy cell circuitry controlling dentate granule cell excitability, Seiichiro Jinde; Veronika Zsiros; Kazu Nakazawa, Feb. 2013, FRONTIERS IN NEURAL CIRCUITS, 7, 14

  DOI
• Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation, Seiichiro Jinde; Veronika Zsiros; Zhihong Jiang; Kazuhito Nakao; James Pickel; Kenji Kohno; Juan E. Belforte; Kazu Nakazawa, Dec. 2012, NEURON, 76, 6, 1189, 1200, Scientific journal

  DOI
• Acute psychosis during the postictal period in a patient with idiopathic generalized epilepsy: Postictal psychosis or aggravation of schizophrenia? A case report and review of the literature, Eisuke Sakakibara; Takuji Nishida; Kazuyuki Sugishita; Seiichiro Jinde; Yushi Inoue; Kiyoto Kasai, Jul. 2012, EPILEPSY & BEHAVIOR, 24, 3, 373, 376

  DOI
• The NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5 (NDUFA5) gene variants are associated with autism, T. Marui; I. Funatogawa; S. Koishi; K. Yamamoto; H. Matsumoto; O. Hashimoto; S. Jinde; H. Nishida; T. Sugiyama; K. Kasai; K. Watanabe; Y. Kano; N. Kato, Feb. 2011, ACTA PSYCHIATRICA SCANDINAVICA, 123, 2, 118, 124, Scientific journal

  DOI
• Association between autism and variants in the wingless-type MMTV integration site family member 2 (WNT2) gene, Tetsuya Marui; Ikuko Funatogawa; Shinko Koishi; Kenji Yamamoto; Hideo Matsumoto; Ohiko Hashimoto; Seiichiro Jinde; Hisami Nishida; Toshiro Sugiyama; Kiyoto Kasai; Keiichiro Watanabe; Yukiko Kano; Nobumasa Kato, May 2010, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13, 4, 443, 449, Scientific journal

  DOI
• Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning, Jonathan L. Brigman; Tara Wright; Giuseppe Talani; Shweta Prasad-Mulcare; Seiichiro Jinde; Gail K. Seabold; Poonam Mathur; Margaret I. Davis; Roland Bock; Richard M. Gustin; Roger J. Colbran; Veronica A. Alvarez; Kazu Nakazawa; Eric Delpire; David M. Lovinger; Andrew Holmes, Mar. 2010, JOURNAL OF NEUROSCIENCE, 30, 13, 4590, 4600, Scientific journal

  DOI
• Levetiracetam inhibits kindling-induced synaptic potentiation in the dentate gyrus of freely moving rats, Yuki Sugaya; Seiichiro Jinde; Nobumasa Kato; Eiichi Maru, Feb. 2010, NEUROSCIENCE RESEARCH, 66, 2, 228, 231, Scientific journal

  DOI
• Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death, Seiichiro Jinde; Juan E. Belforte; Jun Yamamoto; Matthew A. Wilson; Susumu Tonegawa; Kazu Nakazawa, Sep. 2009, EUROPEAN JOURNAL OF NEUROSCIENCE, 30, 6, 1036, 1055, Scientific journal

  DOI
• Influence of age or circadian time on bcl-2 and bax mRNA expression in the rat hippocampus after corticosterone exposure, Atsushi Yoshimura; Akira Masui; Seiichiro Jinde; Hirohiko Kanai; Nobumasa Kato; Masako Okawa, Jul. 2007, BRAIN RESEARCH BULLETIN, 73, 4-6, 254, 258, Scientific journal

  DOI
• Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring, K Kohda; S Jinde; K Iwamoto; M Bundo; N Kato; T Kato, Apr. 2006, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 9, 2, 201, 208, Scientific journal

  DOI
• Differential changes in messenger RNA expressions and binding sites of neuropeptide YY1, Y-2 and Y-5 receptors in the hippocampus of an epileptic mutant rat: Noda epileptic rat, S Jinde; A Masui; S Morinobu; A Noda; N Kato, 2002, NEUROSCIENCE, 115, 4, 1035, 1045, Scientific journal
• Elevated neuropeptide Y and corticotropin-releasing factor in the brain of a novel epileptic mutant rat: Noda epileptic rat, S Jinde; A Masui; S Morinobu; Y Takahashi; K Tsunashima; A Noda; N Yamada; N Kato, Jul. 1999, BRAIN RESEARCH, 833, 2, 286, 290, Scientific journal

  DOI
• Risperidoneが奏功した分裂病型人格障害の一症例, 神出誠一郎; 石田展弥; 山田尚登; 加藤進昌, 1998, 1, 1195, 1200, Scientific journal
• Risperidone が奏効した分裂病型人格障害の1例, Jinde S; Ishida N; Yamada N; Kato N, 1998, 1, 637, 640, Scientific journal

MISC

• 22q11.2欠失症候群メンタルヘルス専門外来における受診動機に関するカルテ調査, 田中 美歩; 熊倉 陽介; 池亀 天平; 榊原 英輔; 小川 知子; 金原 明子; 宇野 晃人; 澤井 大和; 高橋 優輔; 柳下 祥; 金生 由紀子; 神出 誠一郎; 笠井 清登, Nov. 2023, 35, Suppl., S, 188
• 22q11.2欠失症候群メンタルヘルス専門外来における受診動機に関するカルテ調査, 田中 美歩; 熊倉 陽介; 池亀 天平; 榊原 英輔; 小川 知子; 金原 明子; 宇野 晃人; 澤井 大和; 高橋 優輔; 柳下 祥; 金生 由紀子; 神出 誠一郎; 笠井 清登, Nov. 2023, 35, Suppl., S, 188
• 【複合的困難を抱える人達のための精神科医療】22q11.2欠失症候群メンタルヘルス専門外来 複合的困難の声を聴く, 熊倉 陽介; 高橋 優輔; 澤井 大和; 宇野 晃人; 神出 誠一郎; 笠井 清登, Aug. 2023, 38, 8, 879, 885
• 22q11.2欠失症候群の重複障害の解析 療育手帳の有無に伴う医療的困難・ニーズ, 澤井 大和; 宇野 晃人; 高橋 優輔; 田中 美歩; 金原 明子; 熊倉 陽介; 柳下 祥; 神出 誠一郎; 笠井 清登, Jun. 2023, 2023特別号, S571, S571
• 22q11.2欠失症候群のある人と家族が抱える福祉制度に関する困難とニーズ : 混合研究法によるアンケート回答解析—Welfare System Difficulties and Desired Support for Individuals with 22q11.2 Deletion Syndromes and Their Families : Analysis of Web Survey Results by Mixed Method Research, 宇野 晃人; 田中 美歩; 高橋 優輔; 澤井 大和; 熊倉 陽介; 森島 遼; 中島 直美; 金原 明子; 濱田 純子; 小川 知子; 田宗 秀隆; 柳下 祥; 池亀 天平; 榊原 英輔; 金生 由紀子; 神出 誠一郎; 笠井 清登, 2023, 125, 6, 486, 497
• 【精神疾患を最新のゲノム解析・脳画像技術からとらえる】精神疾患と遺伝的多様性, 池亀 天平; 神出 誠一郎, Oct. 2021, 4, 11, 1014, 1017
• 医療・福祉・教育の困難と22q11.2欠失症候群をもつ子の養育者の心の健康, 森島 遼; 熊倉 陽介; 宇佐美 慧; 金原 明子; 田中 美歩; 大河内 範子; 中島 直美; 濱田 純子; 小川 知子; 安藤 俊太郎; 田宗 秀隆; 中原 睦美; 神出 誠一郎; 金生 由紀子; 田中 恭子; 平田 陽一郎; 岡 明; 笠井 清登, 2021, 85, PD-025, PD-025

  DOI
• 22q11.2欠失症候群のある人の家族を対象としたウェブニーズ調査, 熊倉陽介; 熊倉陽介; 森島遼; 田中美歩; 金原明子; 大河内範子; 中島直美; 濱田純子; 小川知子; 田宗秀隆; 中原睦美; 中原睦美; 神出誠一郎; 金生由紀子; 岡明; 笠井清登, 2020, 10, 1
• Identification and validation of DNA methylation changes in the offspring of maternal poly(I:C) injection, 村田唯; 上田順子; 内布恵美; 大西新; 葛西秀俊; 池亀天平; 趙治磊; 神出誠一郎; 饗場篤; 須原哲也; 笠井清登; 加藤忠史; 文東美紀; 岩本和也, 2019, 日本生物学的精神医学会(Web), 41st, 42 (WEB ONLY)
• Infinium MethylationEPIC kitを用いた精神疾患モデルマーモセットにおけるDNAメチル化状態の予備的解析, 上田順子; 村田唯; 文東美紀; 大西新; 葛西秀俊; 池亀天平; 趙治磊; 神出誠一郎; 饗場篤; 須原哲也; 笠井清登; 加藤忠史; 岩本和也, 2017, 日本生化学会大会(Web), 90th, ROMBUNNO.1LBA‐027 (WEB ONLY)
• Identification of Differentially Expressed microRNAs in First-Episode Psychosis, Zhilei Zhao; Shinsuke Koike; Kiyoto Kasai; Seiichiro Jinde, May 2014, BIOLOGICAL PSYCHIATRY, 75, 9, 218S, 218S, Summary international conference
• 心気症状が前景に立った強迫スペクトラム障害の1例, 梅田恵理子; 岡田直大; 音羽健司; 矢野幹一郎; 市橋香代; 神出誠一郎; 笠井清登, 25 Sep. 2013, 精神神経学雑誌, 115, 9, 1009
• 双極性障害II型に線維筋痛症を合併し、mECTに抵抗性を示した1例, 矢野 幹一良; 若林 淳一; 管 心; 音羽 健司; 神出 誠一郎; 笠井 清登, Aug. 2013, 115, 8, 903, 904
• 音楽性幻聴にescitalopramが著効したうつ病の1例, 森田 正哉; 小池 進介; 市橋 香代; 音羽 健司; 神出 誠一郎; 笠井 清登, 25 Jul. 2013, 精神神経学雑誌, 115, 7, 798, 798
• 困難な症例から学ぶ(第45回) 経過とともに診断が変遷していった統合失調症の一例, 森田 健太郎; 切原 賢治; 神出 誠一郎; 笠井 清登, Sep. 2012, Schizophrenia Frontier, 13, 1, 47, 52
• 右側頭葉および後頭葉の欠損を伴う双極性障害の1例, 杉下 瑞希; 蒲谷 洋平; 西田 拓司; 神出 誠一郎; 笠井 清登, Aug. 2012, 114, 8, 995, 996
• 海馬の構造・機能障害と精神疾患 海馬の神経回路と記憶, 神出誠一郎, 10 Apr. 2012, 12, 2, 68, 73
• てんかん発作後に急性精神病を呈した特発性全般てんかんの1例, 榊原 英輔; 西田 拓司; 杉下 和行; 中村 光; 荒木 剛; 神出 誠一郎; 井上 有史; 笠井 清登, Sep. 2011, 精神神経学雑誌, 113, 9, 928, 928
• パニック障害と診断されていた側頭葉てんかんの1例, 杉本 徳子; 西田 拓司; 大久保 裕史; 古川 賢臣; 荒木 剛; 神出 誠一郎; 山末 英典; 笠井 清登, Jan. 2011, 28, 3, 491, 492
• 妊娠中に修正型電気けいれん療法(mECT)を施行した統合失調症の1例, 稲井彩; 稲井彩; 岩白訓周; 音羽健司; 西田拓司; 荒木剛; 神出誠一郎; 山末英典; 中安信夫; 笠井清登, 2011, 113, 2
• Autism spectrum disorders - Recent advances in the research on the impairment in social communication, Nobumasa Kato; Hidenori Yamasue; Keiichiro Watanabe; Seiichiro Jinde; Miyuki Sadamatsu, Sep. 2010, Brain and Nerve, 62, 9, 975, 986, Book review
• 自閉症スペクトラム障害の脳科学―社会性の障害に注目して, 加藤進昌; 加藤進昌; 山末英典; 山末英典; 渡辺慶一郎; 神出誠一郎; 定松美幸, 01 Sep. 2010, 62, 9, 975, 986
• 強制正常化を伴う幻覚妄想状態を呈したヘルペス脳炎後てんかんの1例, 伊敷 一馬; 小椋 哲; 神出 誠一郎; 垣内 千尋; 西田 拓司; 笠井 清登, Mar. 2010, 112, 3, 281, 282
• 統合失調症のグルタミン酸・GABA神経伝達異常, 切原賢治; 荒木剛; 神出誠一郎; 笠井清登, 05 Dec. 2009, 231, 10, 1040, 1044
• 動物に精神医学はあるか 海馬研究はこれからどこに向かうのか, 神出誠一郎, 28 Aug. 2009, 15, 2, 149, 152
• 統合失調症は神経発達障害か,神経変性疾患か 脳画像所見と背景をなす分子病態, 笠井清登; 神出誠一郎, 20 Apr. 2009, 12, 2, 191, 194
• Role of hippocampal NR1 receptor in learning and memory impairment, Seiichiro Jinde; Kazu Nakazawa, 2009, NEUROSCIENCE RESEARCH, 65, S8, S8, Summary international conference

  DOI
• Characterization of dentate mossy cell-restricted NMDA receptor knockout mice, Kazutoshi Nakazawa; Seiichiro Jinde; Catherine J. Cravens; Juan E. Belforte, 2007, NEUROSCIENCE RESEARCH, 58, S14, S14, Summary international conference
• 目で見る精神医学~脳科学の最前線~ 外傷後ストレス障害(PTSD)の脳画像, 山末英典; 神出誠一郎; 加藤進昌, 15 Jun. 2004, 131, 12, S14
• 目で見る精神医学~脳科学の最前線~ 外傷後ストレス障害(PTSD)の分子病態, 武井邦夫; 神出誠一郎; 加藤進昌, 15 Jun. 2004, 131, 12, S15-S16
• FK506 inhibits neuronal death of trimethyltin-induced rats, TSUNASIMA Koichi; SADAMATSU Miyuki; IMAI Hideki; NAKAGAMI Ryuichi; JINDE Seiichiro; KITA Yasuhiro; MORITA Masahiko; NISHIMURA Shintaro; LIU Y.; XU X.; KATO Nobumasa, 25 Dec. 2003, 23, 6, 303, 303
• 精神疾患とニューロジェネシス ストレスとの関係を中心に, 武井邦夫; 神出誠一郎; 幸田和久; 加藤進昌, 25 Jan. 2003, 13, 4, 433, 441
• I E2 The expression of NPY Y2 receptors after kainic acid-induced seizures in hippocampus of mice lacking Y1 receptors, Jinde Seiichiro; Takei Kunio; Nakamura Motonao; Kato Nobumasa, 11 Sep. 2002, 36, 141, 141
• てんかんの分子生物学 NPYとてんかん 海馬における作用を中心に, 神出誠一郎; 増井晃; 加藤進昌, 25 Jul. 2001, 1, 4, 375, 381
• C-3 自発性てんかんモデルの発作後海馬におけるニューロペプチドY受容体の経時的変化, 神出誠一郎; 増井晃; 高橋良斉; 野田篤; 加藤進昌, 21 Sep. 2000, 34, 82, 82
• The expression of neuropeptide YY2 receptor in the hippocampus of epileptic mutant rat; Noda epileptic rat (NER), S Jinde; A Masui; S Morinobu; Y Takahashi; M Sadamatsu; H Kanai; N Ishida; N Yamada; A Noda; N Koto, 1999, EPILEPSIA, 40, 36, 36, Summary international conference
• 図解ホルモンのすべて 分子生物学的観点から I. 視床下部―下垂体 ニューロペプチドY 神経ペプチドの中枢作用について, 神出誠一郎; 増井晃; 加藤進昌, May 1998, 46, 152, 164
• Alprazolamが奏効した季節性感情障害の1症例, 神出誠一郎; 山田尚登; 加藤進昌, May 1998, 40, 5, 539, 541

  DOI

Research Projects

• 01 Apr. 2021, 31 Mar. 2024, 21K07539

  対象リソースIRI
• Understanding the mechanisms of epileptogenesis in the hippocampal dentate gyrus using in vivo calcium imaging., Jinde Seiichiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 01 Apr. 2018, 31 Mar. 2021, Mossy cells in the hippocampal dentate gyrus are known to be deeply involved in the pathophysiology of temporal lobe epilepsy, but the exact role of mossy cells has not been elucidated. In the present study, the activity of mossy cells was visualized during epileptic seizures in the awake state by combining the mice that can be genetically engineered specifically for mossy cells with in vivo calcium imaging. The results showed that the activity of mossy cells was largely affected by increased activity along with behavioral epileptic seizures, and that, when the mossy cells was excited, the epileptic activity of granule cells in the dentate gyrus was increased. These studies have revealed a part of the mechanisms of epileptogenesis in temporal lobe epilepsy, and are further expected to lead to the development of new therapies in the future., 18K07589

  対象リソースIRI
• Development of neuroimaging-based, translatable biomarkers applicable to both human and mouse, Yahata Noriaki; KASAI Kiyoto; JINDE Seiichiro; TANAKA Shinji; AOKI Ichio, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 01 Apr. 2013, 31 Mar. 2016, We aimed to establish a neuroimaging-based biomarker that allows quantitative characterization of autism in the mouse-to-human translational research. Specifically, by using magnetic resonance imaging, we conducted longitudinal measurements of mouse brains (C57BL/6J) and thereby explored differential characteristics of the structure and spontaneous activity between autism model and wild-type mice. Conducting voxel-based morphometry on the structural images, inter-regional functional connectivity analysis on the resting-state functional images, as well as comparison of these findings with independent human studies, we have identified that gray matter volume and functional connectivity involving the limbic system through basal ganglia are candidate biomarkers of autism that are common to both human and mouse. Future investigation on their relationship with autism-specific behavioral phenotypes (such as socio-communicative deficits) is required to further clarify the clinical implication., 25461752

  対象リソースIRI
• Studies on the role of hippocampal glutamatergic system in cognitive function using hippocampal subregion-specific NMDA receptor knockout mice, JINDE Seichiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 2010, 2012, In this study, a conditional NMDA receptor subunit 1 (NR1) knockout mouse strain, in which NR1 is selectively ablated in the hippocampal mossy cells by 12week of age, were subjected to histological and behavioral analyses to elucidate the functional role of mossy cells on cognition or emotion. This strain showed the reduced emotional reactivity and the decreased hippocampal neurogenesis. These results implicate thecrucial role of mossy cell NR1 in the maturation of newly generated dentate granule cells, which may regulate emotional behavior., 22591274

  対象リソースIRI
• 2005, 2006, 17790805

  対象リソースIRI
• The effects of hippocampal degeneration during development on the stress susceptibility of animal models of stress, TSUNASHIMA Koichi; WATANABE Keiichiro; KOHDA Kazuhisa; JINDE Seiichiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), The University of Tokyo, 2003, 2004, 1.Bisphenol A (BPA) model : BPA, one of the endocrine disrupters, is widely known to act as an estrogen receptor agonist. In this study, we examined whether a perinatal exposure to a low dose BPA modulates the stress sensitivity including the functions of HPA-axis and neurotrophic factiors in later life. In female rats, the serum corticosterone (CORT) level of BPA+ rats was significantly higher than BPA-rats under basal conditions. No difference was observed in CORT level immediately after the immobilization stress, whereas CORT level of BPA+ rats was significantly higher than BPA-rats 12 h after the immobilization stress. In male rats, there was no difference between BPA+ and BPA-rats in the serum corticosterone level under basal conditions nor after the immobilization stress. No difference was detected in the expression of GR, BDNF and c-fos mRNA between BPA+ and BPA-rats before treatment nor after a stress. 2.Maternal separation (MS) model : In experimental animals, maternal separation (MS) during neonatal period was found critical for susceptibility to stress in adult offspring. Differential gene expression caused by the MS stress was investigated with DNA microarray analysis using the rat hippocampal samples. RT-PCR was also performed to validate the results. Expression of transthyretin (TTR) was drastically reduced in the MS group. It is known that TTR is specifically expressed in the choroid plexus (CP). When normalized by prostaglandin D synthase, TTR still indicated significant decrease. The two other CP-enriched genes, angiotensin I converting enzyme I and insulin-like growth factor II, were also significantly down-regulated in the MS group. Considering that TTR is a carrier protein of thyroid hormone and retinol and that those factors are indispensable for neuronal development and function, significant reduction of TTR should have critical roles in generation of stress susceptibility., 15591211

  対象リソースIRI