Researcher Profile and Settings

Researcher

• Name

  NAKAMURA Kazuhiro

Profile and Settings

• Name

  Nakamura, Kazuhiro

Affiliation

• Gunma University, Professor

Education

• 1984, 1990
• 1994, 1998, The University of Tokyo

Degree

• doctor

Research Experience

• Gunma University

Research Activities

Research Areas

• Life sciences, Pathobiochemistry

Research Interests

• Neurodegeneration

Published Papers

• Infrared free electron laser-irradiated polyleucine does not exert aggregates-induced aversive effects on mouse brain, Ayaka Mori, Taichi Shiroishi, Jun Fujioka, Takashi Nakajima, Shinichi Mitsui, Hinaho Suginoma, Yohei Kakuta, Heishun Zen, Kazuhiro Nakamura, May 2024, Brain Disorders, 14, 100137
• Exogenous polyserine fibrils change membrane properties of phosphatidylcholine-liposome and red blood cells, Yutaro Iizuka, Akiko Katano-Toki, Fumio Hayashi, Jun Fujioka, Hiroshi Takahashi, Kazuhiro Nakamura, May 2024, Biochim Biophys Acta Biomembr, 1866, 184331
• Inner and outer penetrating spinal cord injuries lead to distinct overground walking in mice, Shirota Y, Otani T, Wasada S, Ito S, Mieda T, Nakamura K, Feb. 2024, IBRO Neuroscience Reports, 16, 345, 352
• Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice, Hinaho Suginoma, Ryuji Owada, Akiko Katano-Toki, Ayaka Mori, Jun Fujioka, Kazuhiro Nakamura, Jan. 2024, PLOS ONE, 19, 1, e0296750, e0296750
• Dissociation process of polyalanine aggregates by free electron laser irradiation., Sep. 2023, PLOS ONE, 18, e0291093, e0291093
• Probing protein misfolding and dissociation with an infrared free-electron laser, Okumura H, Kawasaki T, Nakamura K., 2023, Methods Enzymol., 679, 679, 65, 96
• Exogenous polyserine and polyleucine are toxic to recipient cells, Owada R, Mitsui S, Nakamura K, Jan. 2022, Sci. Rep., 12, 1, 1685, 1685
• Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice, Owada R, Kakuta Y, Yoshida k, Mitsui S, Nakamura K., Nov. 2022, Sci. Rep., 12, 1, 18718, 18718
• A simple scoring of beam walking performance after spinal cord injury in mice, Shunsuke Ito, Yohei Kakuta, Kosuke Yoshida, Yuma Shirota, Tokue Mieda, Yoichi Iizuka, Hirotaka Chikuda, Haku Iizuka and Kazuhiro Nakamura, Aug. 2022, PLOS ONE, 17, 8, e0272233, e0272233
• Application study of infrared free-electron lasers towards the development of amyloidosis therapy, Jindo, Mikiko;Nakamura, Kazuhiro;Okumura, Hisashi;Tsukiyama, Koichi;Kawasaki, Takayasu, 2022, JOURNAL OF SYNCHROTRON RADIATION, 29, 1133, 1140

  DOI
• Role of Water Molecules and Helix Structure Stabilization in the Laser-Induced Disruption of Amyloid Fibrils Observed by Nonequilibrium Molecular Dynamics Simulations, Okumura, Hisashi;Itoh, Satoru G.;Nakamura, Kazuhiro;Kawasaki, Takayasu, 2021, JOURNAL OF PHYSICAL CHEMISTRY B, 125, 19, 4964, 4976

  DOI
• Toxicity of internalized polyalanine to cells depends on aggregation, Iizuka Y, Owada R, Kawasaki T, Hayashi F , Sonoyama M , Nakamura K, Dec. 2021, Sci. Rep., 11, 1, 23441, 23441
• Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells., Owada Ryuji;Awata Saaya;Suzue Kazutomo;Kanetaka Hiroyasu;Kakuta Yohei;Nakamura Kazuhiro, 06 Sep. 2020, Heliyon, 6, 9, e04851

  DOI
• Spontaneous functional full recovery from motor and sensory deficits in adult mice after mild spinal cord injury, Kakuta, Yohei;Adachi, Anna;Yokohama, Marino;Horii, Toshiki;Mieda, Tokue;Iizuka, Yoichi;Takagishi, Kenji;Chikuda, Hirotaka;Iizuka, Haku;Nakamura, Kazuhiro, 2019, HELIYON, 5, 6, e01847, e01847

  DOI
• Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells, Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K, Oct. 2018, 685, 42, 49

  DOI
• Dissociation of Beta-Sheet Stacking of Amyloid Beta Fibrils by Irradiation of Intense, Short-Pulsed Mid-infrared Laser., Kawasaki T, Yaji T, Ohta T, Tsukiyama K, Nakamura K, 2018, CELLULAR AND MOLECULAR NEUROBIOLOGY, 38, 5, 1039, 1049

  DOI
• Picosecond pulsed infrared laser tuned to amide I band dissociates polyglutamine fibrils in cells, Takayasu Kawasaki Gaku Ohori Tomoyuki Chiba Koichi Tsukiyama Kazuhiro Nakamura, Sep. 2016, Lasers Med Sci, 31, 7, 1425, 1431

Presentations

• Dissociation of polyleucine aggregate by free electron laser irradiation, Ayaka Mori, Hinaho Suginoma, Yuma Shirota, Kosuke Yoshida, Heishun Zen, Kazuhiro Nakamura, 13th International Symposium of Advanced Energy Science, 05 Sep. 2022, 06 Sep. 2022, Kyoto, Japan, International conference