研究者基本情報

研究者

• 氏名

  中村　和裕, ナカムラ　カズヒロ

基本情報

• 研究者氏名（日本語）

  中村, 和裕

• 研究者氏名（カナ）

  ナカムラ, カズヒロ

所属

• 群馬大学, 教授

学歴

• 1984年, 1990年, 筑波大学, 医学専門学群
• 1994年, 1998年, 東京大学大学院, 医学系研究科, 機能生物学

学位

• 博士

経歴

• 群馬大学

研究活動情報

研究分野

• ライフサイエンス, 病態医化学

研究キーワード

• Neurodegeneration

論文

• Infrared free electron laser-irradiated polyleucine does not exert aggregates-induced aversive effects on mouse brain, Ayaka Mori, Taichi Shiroishi, Jun Fujioka, Takashi Nakajima, Shinichi Mitsui, Hinaho Suginoma, Yohei Kakuta, Heishun Zen, Kazuhiro Nakamura, 2024年05月, Brain Disorders, 14, 100137
• Exogenous polyserine fibrils change membrane properties of phosphatidylcholine-liposome and red blood cells, Yutaro Iizuka, Akiko Katano-Toki, Fumio Hayashi, Jun Fujioka, Hiroshi Takahashi, Kazuhiro Nakamura, 2024年05月, Biochim Biophys Acta Biomembr, 1866, 184331
• Inner and outer penetrating spinal cord injuries lead to distinct overground walking in mice, Shirota Y, Otani T, Wasada S, Ito S, Mieda T, Nakamura K, 2024年02月, IBRO Neuroscience Reports, 16, 345, 352
• Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice, Hinaho Suginoma, Ryuji Owada, Akiko Katano-Toki, Ayaka Mori, Jun Fujioka, Kazuhiro Nakamura, 2024年01月, PLOS ONE, 19, 1, e0296750, e0296750
• Dissociation process of polyalanine aggregates by free electron laser irradiation., 2023年09月, PLOS ONE, 18, e0291093, e0291093
• Probing protein misfolding and dissociation with an infrared free-electron laser, Okumura H, Kawasaki T, Nakamura K., 2023年, Methods Enzymol., 679, 679, 65, 96
• Exogenous polyserine and polyleucine are toxic to recipient cells, Owada R, Mitsui S, Nakamura K, 2022年01月, Sci. Rep., 12, 1, 1685, 1685
• Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice, Owada R, Kakuta Y, Yoshida k, Mitsui S, Nakamura K., 2022年11月, Sci. Rep., 12, 1, 18718, 18718
• A simple scoring of beam walking performance after spinal cord injury in mice, Shunsuke Ito, Yohei Kakuta, Kosuke Yoshida, Yuma Shirota, Tokue Mieda, Yoichi Iizuka, Hirotaka Chikuda, Haku Iizuka and Kazuhiro Nakamura, 2022年08月, PLOS ONE, 17, 8, e0272233, e0272233
• Application study of infrared free-electron lasers towards the development of amyloidosis therapy, Jindo, Mikiko;Nakamura, Kazuhiro;Okumura, Hisashi;Tsukiyama, Koichi;Kawasaki, Takayasu, 2022年, JOURNAL OF SYNCHROTRON RADIATION, JOURNAL OF SYNCHROTRON RADIATION, 29, 1133, 1140

  DOI
• Role of Water Molecules and Helix Structure Stabilization in the Laser-Induced Disruption of Amyloid Fibrils Observed by Nonequilibrium Molecular Dynamics Simulations, Okumura, Hisashi;Itoh, Satoru G.;Nakamura, Kazuhiro;Kawasaki, Takayasu, 2021年, JOURNAL OF PHYSICAL CHEMISTRY B, JOURNAL OF PHYSICAL CHEMISTRY B, 125, 19, 4964, 4976

  DOI
• Toxicity of internalized polyalanine to cells depends on aggregation, Iizuka Y, Owada R, Kawasaki T, Hayashi F , Sonoyama M , Nakamura K, 2021年12月, Sci. Rep., 11, 1, 23441, 23441
• Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells., Owada Ryuji;Awata Saaya;Suzue Kazutomo;Kanetaka Hiroyasu;Kakuta Yohei;Nakamura Kazuhiro, 2020年09月06日, Heliyon, Heliyon, 6, 9, e04851

  DOI
• Spontaneous functional full recovery from motor and sensory deficits in adult mice after mild spinal cord injury, Kakuta, Yohei;Adachi, Anna;Yokohama, Marino;Horii, Toshiki;Mieda, Tokue;Iizuka, Yoichi;Takagishi, Kenji;Chikuda, Hirotaka;Iizuka, Haku;Nakamura, Kazuhiro, 2019年, HELIYON, 5, 6, e01847, e01847

  DOI
• Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells, Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K, 2018年10月, Neuroscience Letters, 685, 42, 49

  DOI
• Dissociation of Beta-Sheet Stacking of Amyloid Beta Fibrils by Irradiation of Intense, Short-Pulsed Mid-infrared Laser., Kawasaki T, Yaji T, Ohta T, Tsukiyama K, Nakamura K, 2018年, CELLULAR AND MOLECULAR NEUROBIOLOGY, 38, 5, 1039, 1049

  DOI
• Picosecond pulsed infrared laser tuned to amide I band dissociates polyglutamine fibrils in cells, Takayasu Kawasaki Gaku Ohori Tomoyuki Chiba Koichi Tsukiyama Kazuhiro Nakamura, 2016年09月, Lasers Med Sci, 31, 7, 1425, 1431

講演・口頭発表等

• Dissociation of polyleucine aggregate by free electron laser irradiation, Ayaka Mori, Hinaho Suginoma, Yuma Shirota, Kosuke Yoshida, Heishun Zen, Kazuhiro Nakamura, 13th International Symposium of Advanced Energy Science, 2022年09月05日, 2022年09月06日, 国際会議