Researcher Profile and Settings

Researcher

• Name

  TORII SEIJI

Profile and Settings

• Name

  SEIJI, TORII

Website

• URI

  http://www.imcr.gunma-u.ac.jp/lab/secbio/

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University

Degree

• Master

Association Memberships

• JAPANESE SOCIETY FOR CHEMICAL BIOLOGY

Research Experience

• Jul. 2011, Dec. 2018, Gunma Univ, IMCR, Associate professor, Associate prof lecturer lv
• Sep. 1999, Jun. 2011, Gunma Univ, IMCR, Assistant professor, Assistant prof lv
• 1994, 1997
• 1997, 1999
• 1997, 1999, Post doctoral fellow

Research Activities

Research Areas

• Life sciences, Health Science
• Life sciences, Cell biology
• Life sciences, Physiology

Research Interests

• Peptide hormone
• Secretory granule
• Protein-tyrosine phosphatase
• Fluorescent imaging
• Cell death Growth Secretion Hormone Insulin Vesicle transport Intracellular localization Signal transduction

Published Papers

• Dominant Expression of Chromogranin B in Pituitary Corticotrophs and Its Putative Role in Interaction With Secretogranin III., Kikuchi S, Odashima K, Yasui T, Torii S, Hosaka M, Gomi H., Jan. 2025, Histochem Cell Biol, 73, 1-2, 29, 53
• Exposure to volatile ferroptosis inhibitor, TEMPO, reduced cutaneous ischemia-reperfusion injury progression to pressure ulcer formation in a mouse model., Ishikawa M, Uchiyama A, Kosaka K, Nishio M, Ogino S, Yokoyama Y, Torii R, Akai R, Iwawaki T, Torii S, Motegi SI, Sep. 2024, J Dermatol Sci, 115, 3, 130, 140, Scientific journal

  DOI
• Phogrin regulates high-fat diet-induced compensatory pancreatic β-cell growth by switching binding partners, Kubota C, Torii R, Hosaka M, Takeuchi T, Gomi H, Torii S, 04 Jan. 2024, Nutrients, 16, 1, 169

  DOI
• Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene, 2. Yasui T, Mashiko M, Obi A, Mori H, Ito-Murata M, Hayakawa H, Kikuchi S, Hosaka M, Kubota C, Torii S, Gomi H, 27 Dec. 2023, Histochem Cell Biol, Scientific journal

  DOI
• Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine, Seiya Nagai, Masaki Yoshida, Yuta Takigawa, Seiji Torii, Ichiro Koshiishi, May 2021, Food Chemistry, 343, 128511

  DOI
• The antipsychotic olanzapine-induced misfolding of proinsulin in the endoplasmic reticulum accounts for atypical development of diabetes, 3. Ninagawa S, Tada S, Okumura M, Inoguchi K, Kinoshita M, Kanemura S, Imami K, Umezawa H, Ishikawa T, Mackin RB, Torii S, Ishihama Y, Inaba K, Anazawa T, Nagamine T, Mori K, Nov. 2020, ELife, 9, -, e60970, e60970

  DOI
• Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a, Leonard M. G. Chavas,Kentaro Ihara,Masato Kawasaki,Seiji Torii,Tamami Uejima,Ryuichi Kato,Tetsuro Izumi,Soichi Wakatsuki, Oct. 2008, STRUCTURE, 16, 10, 1468, 1477, Scientific journal

  DOI
• TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer, N Pathan,H Marusawa,M Krajewska,S Matsuzawa,H Kim,K Okada,S Tori,S Kitada,S Krajewski,K Welsh,F Pio,A Godzik,JC Reed, Aug. 2001, JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 34, 32220, 32229, Scientific journal

  DOI
• Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content, Hiroshi Gomi,Satomi Morikawa,Naoki Shinmura,Hiroaki Moki,Tadashi Yasui,Azuma Tsukise,Seiji Torii,Tsuyoshi Watanabe,Yoshinori Maeda,Masahiro Hosaka, May 2015, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 63, 5, 350, 366, Scientific journal

  DOI
• Immunohistochemical Analysis of IA-2 Family of Protein Tyrosine Phosphatases in Rat Gastrointestinal Endocrine Cells, Hiroshi Gomi,Chisato Kubota-Murata,Tadashi Yasui,Azuma Tsukise,Seiji Torii, Feb. 2013, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 61, 2, 156, 168, Scientific journal

  DOI
• Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappa B, Rhonda Croxton,Lorena A. Puto,Ian de Belle,Michael Thomas,Seiji Torii,Farid Hanaii,Michael Cuddy,John C. Reed, Sep. 2006, CANCER RESEARCH, 66, 18, 9026, 9035, Scientific journal

  DOI
• Regulation of association of a 58-kDa peripheral membrane protein (58K) with the Golgi apparatus: Its membrane binding properties related to but distinct from those of COP I coat proteins, S Torii,K Murakami,K Nakayama, Feb. 1997, BIOMEDICAL RESEARCH-TOKYO, 18, 1, 37, 47, Scientific journal

  DOI
• Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p, HW Shin,C Shinotsuka,S Torii,K Murakami,K Nakayama, Sep. 1997, JOURNAL OF BIOCHEMISTRY, 122, 3, 525, 530, Scientific journal

  DOI
• CYTOTOXICITY OF BREFELDIN-A CORRELATES WITH ITS INHIBITORY EFFECT ON MEMBRANE-BINDING OF COP COAT PROTEINS, S TORII,T BANNO,T WATANABE,Y IKEHARA,K MURAKAMI,K NAKAYAMA, May 1995, JOURNAL OF BIOLOGICAL CHEMISTRY, 270, 19, 11574, 11580, Scientific journal

  DOI
• Cytoplasmic transport signal is involved in phogrin targeting and localization to secretory granules, S Torii,N Saito,A Kawano,SL Zhao,T Izumi,T Takeuchi, Dec. 2005, TRAFFIC, 6, 12, 1213, 1224, Scientific journal

  DOI
• Functional analysis of Rab27a effector granuphilin in insulin exocytosis, T Izumi,H Gomi,S Torii, 2005, GTPASES REGULATING MEMBRANE TARGETING AND FUSION, 403, 18, 216, 229, In book

  DOI
• Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs), S Torii,DA Egan,RA Evans,JC Reed, Nov. 1999, EMBO JOURNAL, 18, 21, 6037, 6049, Scientific journal

  DOI
• Preferential Release of Newly Synthesized Insulin Assessed by a Multi-Label Reporter System Using Pancreatic beta-Cell Line MIN6, Ni Hou,Hideo Mogami,Chisato Kubota-Murata,Meng Sun,Toshiyuki Takeuchi,Seiji Torii, Oct. 2012, PLOS ONE, 7, 10, e47921, Scientific journal

  DOI
• GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-golgi and involved in membrane association of the COPI coat, K Kawamoto,Y Yoshida,H Tamaki,S Torii,C Shinotsuka,S Yamashina,K Nakayama, Jul. 2002, TRAFFIC, 3, 7, 483, 495, Scientific journal

  DOI
• Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions, K Nagashima,S Torii,ZH Yi,M Igarashi,K Okamoto,T Takeuchi,T Izumi, Apr. 2002, FEBS LETTERS, 517, 1-3, 233, 238, Scientific journal

  DOI
• Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a, S Torii,SL Zhao,ZH Yi,T Takeuchi,T Izumi, Aug. 2002, MOLECULAR AND CELLULAR BIOLOGY, 22, 15, 5518, 5526, Scientific journal

  DOI
• The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules, Z Yi,H Yokota,S Torii,T Aoki,M Hosaka,S Zhao,K Takata,T Takeuchi,T Izumi, Mar. 2002, MOLECULAR AND CELLULAR BIOLOGY, 22, 6, 1858, 1867, Scientific journal

  DOI
• Involvement of Rab27b in the regulated secretion of pituitary hormones, SL Zhao,S Torii,H Yokota-Hashimoto,T Takeuchi,T Izumi, May 2002, ENDOCRINOLOGY, 143, 5, 1817, 1824, Scientific journal

  DOI
• Parathyroid hormone-related protein induces insulin expression through activation of MAP kinase-specific phosphatase-1 that dephosphorylates c-Jun NH2-terminal kinase in pancreatic beta-cells, B Zhang,M Hosaka,Y Sawada,S Torii,S Mizutani,M Ogata,T Izumi,T Takeuchi, Nov. 2003, DIABETES, 52, 11, 2720, 2730, Scientific journal

  DOI
• Functional localization of proprotein-convertase furin and its substrate TGF beta in EGF receptor-expressing gastric chief cells, T Fujisawa,H Kamimura,M Hosaka,S Torii,T Izumi,H Kuwano,T Takeuchi, Mar. 2004, GROWTH FACTORS, 22, 1, 51, 59, Scientific journal

  DOI
• Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3, Ryosuke Shintoku,Yuta Takigawa,Keiichi Yamada,Chisato Kubota,Yuhei Yoshimoto,Toshiyuki Takeuchi,Ichiro Koshiishi,Seiji Torii, Nov. 2017, CANCER SCIENCE, 108, 11, 2187, 2194, Scientific journal

  DOI
• Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a, S Torii,T Takeuchi,S Nagamatsu,T Izumi, May 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 21, 22532, 22538, Scientific journal

  DOI
• Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene, M Aihara,K Sugawara,S Torii,M Hosaka,H Kurihara,N Saito,T Takeuchi, Dec. 2004, LABORATORY INVESTIGATION, 84, 12, 1581, 1592, Scientific journal

  DOI
• An essential role for functional lysosomes in ferroptosis of cancer cells, Seiji Torii,Ryosuke Shintoku,Chisato Kubota,Makoto Yaegashi,Ryoko Torii,Masaya Sasaki,Toshinobu Suzuki,Masanobu Mori,Yuhei Yoshimoto,Toshiyuki Takeuchi,Keiichi Yamada, Mar. 2016, BIOCHEMICAL JOURNAL, 473, 6, 769, 777, Scientific journal

  DOI
• IDENTIFICATION AND FUNCTIONAL EXPRESSION OF A NEW MEMBER OF THE MAMMALIAN KEX2-LIKE PROCESSING ENDOPROTEASE FAMILY - ITS STRIKING STRUCTURAL SIMILARITY TO PACE4, T NAKAGAWA,M HOSAKA,S TORII,T WATANABE,K MURAKAMI,K NAKAYAMA, Feb. 1993, JOURNAL OF BIOCHEMISTRY, 113, 2, 132, 135
• LOCALIZATION OF KEX2-LIKE PROCESSING ENDOPROTEASES, FURIN AND PC4, WITHIN MOUSE TESTIS BY INSITU HYBRIDIZATION, S TORII,T YAMAGISHI,K MURAKAMI,K NAKAYAMA, Jan. 1993, FEBS LETTERS, 316, 1, 12, 16, Scientific journal

  DOI
• Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2, M Haraguchi,S Torii,S Matsuzawa,ZH Xie,S Kitada,S Krajewski,H Yoshida,TW Mak,JC Reed, May 2000, JOURNAL OF EXPERIMENTAL MEDICINE, 191, 10, 1709, 1720, Scientific journal

  DOI
• Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages, Rei Yamaguchi,Masahiro Hosaka,Seiji Torii,Ni Hou,Nobuhito Saito,Yuhei Yoshimoto,Hideaki Imai,Toshiyuki Takeuchi, Jun. 2011, BRAIN RESEARCH, 1397, 55, 65, Scientific journal

  DOI
• Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6), M Hosaka,K Toda,H Takatsu,S Torii,K Murakami,K Nakayama, Oct. 1996, JOURNAL OF BIOCHEMISTRY, 120, 4, 813, 819, Scientific journal

  DOI
• ATAT1 is essential for regulation of homeostasis-retaining cellular responses in corticotrophs along hypothalamic-pituitary-adrenal axis, Takashi Nakakura,Takeshi Suzuki,Seiji Torii,Anshin Asano-Hoshino,Yoko Nekooki-Machida,Hideyuki Tanaka,Kenjiro Arisawa,Yoshimi Nishijima,Takao Susa,Tomoki Okazaki,Yoshiko Kiuchi,Haruo Hagiwara, Oct. 2017, CELL AND TISSUE RESEARCH, 370, 1, 169, 178, Scientific journal

  DOI
• IDENTIFICATION OF THE 4TH MEMBER OF THE MAMMALIAN ENDOPROTEASE FAMILY HOMOLOGOUS TO THE YEAST KEX2 PROTEASE - ITS TESTIS-SPECIFIC EXPRESSION, K NAKAYAMA,WS KIM,S TORII,M HOSAKA,T NAKAGAWA,J IKEMIZU,T BABA,K MURAKAMI, Mar. 1992, JOURNAL OF BIOLOGICAL CHEMISTRY, 267, 9, 5897, 5900, Scientific journal
• VAMP7 Regulates Autophagosome Formation by Supporting Atg9a Functions in Pancreatic β-Cells From Male Mice., Aoyagi K,Itakura M,Fukutomi T,Nishiwaki C,Nakamichi Y,Torii S,Makiyama T,Harada A,Ohara-Imaizumi M, Nov. 2018, Endocrinology, 159, 11, 3674, 3688

  DOI
• Impaired processing of prohormones in secretogranin III-null mice causes maladaptation to an inadequate diet and stress, Yoshinori Maeda,Saki Kudo,Ken Tsushima,Eri Sato,Chisato Kubota,Chisato Kubota,Aika Kayamori,Hiroki Bochimoto,Daisuke Koga,Seiji Torii,Hiroshi Gomi,Tsuyoshi Watanabe,Masahiro Hosaka, 01 Feb. 2018, Endocrinology, 159, 2, 1213, 1227

  DOI
• Leucine-based signal in the cytoplasmic tail contributes targeting and localization of integral glycoprotein, phogrin, to secretory granules, Torii, Seiji;Saito, Naoya;Kawano, Ayumi;Takeuchi, Toshiyuki, 2005, CELL STRUCTURE AND FUNCTION, 30, 22, 22
• Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a, Torii, Seiji;Takeuchi, Toshiyuki;Izumi, Tetsuro, 2004, CELL STRUCTURE AND FUNCTION, 29, 108, 108
• Molecular probes for sensing the cholesterol composition of subcellular organelle membranes, Wang, Rong;Hosaka, Masahiro;Han, Lu;Yokota-Hashimoto, Hiromi;Suda, Masayuki;Mitsushima, Dai;Torii, Seiji;Takeuchi, Toshiyuki, 2006, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1761, 10, 1169, 1181

  DOI
• Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain, Yu, Miao;Kasai, Kazuo;Nagashima, Kazuaki;Torii, Seiji;Yokota-Hashimoto, Hiromi;Okamoto, Koichi;Takeuchi, Toshiyuki;Gomi, Hiroshi;Izumi, Tetsuro, 2007, MOLECULAR BIOLOGY OF THE CELL, 18, 2, 688, 696

  DOI
• Structure of the small GTPase Rab27b shows an unexpected swapped dimer, Chavas, Leonard M. G.;Torii, Seiji;Kamikubo, Hironari;Kawasaki, Masato;Ihara, Kentaro;Kato, Ryuichi;Kataoka, Mikio;Izumi, Tetsuro;Wakatsuki, Soichi, 2007, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 63, 769, 779

  DOI
• Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and C-jun N-terminal kinase, and mitogen-activated protein kinase phosphatases, Hou, Ni;Torii, Seiji;Saito, Naoya;Hosaka, Masahiro;Takeuchi, Toshiyuki, 2008, ENDOCRINOLOGY, 149, 4, 1654, 1665

  DOI
• Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic beta-Cell Growth, Torii, Seiji;Saito, Naoya;Kawano, Ayumi;Hou, Ni;Ueki, Kohjiro;Kulkarni, Rohit N.;Takeuchi, Toshiyuki, 2009, DIABETES, 58, 3, 682, 692

  DOI
• Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity, Kubota, Chisato;Torii, Seiji;Hou, Ni;Saito, Nobuhito;Yoshimoto, Yuhei;Imai, Hideaki;Takeuchi, Toshiyuki, 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 1, 667, 674

  DOI
• Luminal Interaction of Phogrin with Carboxypeptidase E for Effective Targeting to Secretory Granules, Saito, Naoya;Takeuchi, Toshiyuki;Kawano, Ayumi;Hosaka, Masahiro;Hou, Ni;Torii, Seiji, 2011, TRAFFIC, 12, 4, 499, 506

  DOI
• Multiple Sorting Systems for Secretory Granules Ensure the Regulated Secretion of Peptide Hormones, Sun, Meng;Watanabe, Tsuyoshi;Bochimoto, Hiroki;Sakai, Yuko;Torii, Seiji;Takeuchi, Toshiyuki;Hosaka, Masahiro, 2013, TRAFFIC, 14, 2, 205, 218

  DOI
• Expression of Secretogranin III in Chicken Endocrine Cells: Its Relevance to the Secretory Granule Properties of Peptide Prohormone Processing and Bioactive Amine Content, Gomi, Hiroshi;Morikawa, Satomi;Shinmura, Naoki;Moki, Hiroaki;Yasui, Tadashi;Tsukise, Azuma;Torii, Seiji;Watanabe, Tsuyoshi;Maeda, Yoshinori;Hosaka, Masahiro, 2015, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 63, 5, 350, 366

  DOI
• VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic beta-Cells, Aoyagi, Kyota;Ohara-Imaizumi, Mica;Itakura, Makoto;Torii, Seiji;Akimoto, Yoshihiro;Nishiwaki, Chiyono;Nakamichi, Yoko;Kishimoto, Takuma;Kawakami, Hayato;Harada, Akihiro;Takahashi, Masami;Nagamatsu, Shinya, 2016, DIABETES, 65, 6, 1648, 1659

  DOI
• Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties, Gomi, Hiroshi;Osawa, Hiromi;Uno, Rie;Yasui, Tadashi;Hosaka, Masahiro;Torii, Seiji;Tsukise, Azuma, 2017, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 65, 11, 637, 653

  DOI
• Lipid peroxide accumulation enhances iron-dependent cell death ferroptosis in cancer cells, Torii, Seiji, 2018, CANCER SCIENCE, 109, 586, 586
• Expression Pattern of the LacZ Reporter in Secretogranin III Gene-trapped Mice, Gomi, Hiroshi;Hinata, Airi;Yasui, Tadashi;Torii, Seiji;Hosaka, Masahiro, 2021, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69, 4, 229, 243

  DOI
• MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines, Tomita, Kazuo;Nagasawa, Taisuke;Kuwahara, Yoshikazu;Torii, Seiji;Igarashi, Kento;Roudkenar, Mehryar Habibi;Roushandeh, Amaneh Mohammadi;Kurimasa, Akihiro;Sato, Tomoaki, 2021, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22, 15, 8300

  DOI
• Differential Expression of Secretogranins II and III in Canine Adrenal Chromaffin Cells and Pheochromocytomas, Gomi, Hiroshi;Nagumo, Takahiro;Asano, Kazushi;Konosu, Makoto;Yasui, Tadashi;Torii, Seiji;Hosaka, Masahiro, 2022, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 70, 5, 335, 356

  DOI
• 2,2,6,6-Tetramethylpiperidine-1-oxyl acts as a volatile inhibitor of ferroptosis and neurological injury, Mizuno, Hiroyuki;Kubota, Chisato;Takigawa, Yuta;Shintoku, Ryosuke;Kannari, Naokatsu;Muraoka, Takako;Obinata, Hideru;Yoshimoto, Yuhei;Kanazawa, Masato;Koshiishi, Ichiro;Torii, Seiji, 2022, JOURNAL OF BIOCHEMISTRY, 172, 2, 71, 78

  DOI
• Structure-Activity Relationship of Cytotoxic Cyclic Peptide Sansalvamide A, UENO Hiromasa;YAMADA Keiichi;FUJISAWA Tomomi;TORII Seiji;HOSAKA Masahiro;OKU Hiroyuki;TAKEUCHI Toshiyuki;KATAKAI Ryoichi, Mar. 2008, 2007, 281, 284
• Expression and Function of IA-2 Family Proteins, Unique Neuroendocrine-specific Protein-tyrosine Phosphatases, TORII SEIJI, Aug. 2009, Endocrine Journal, 56, 5, 639, 648
• The Roles of Rab27 and Its Effectors in the Regulated Secretory Pathways, Izumi Tetsuro;Gomi Hiroshi;Kasai Kazuo;Mizutani Shin;Torii Seiji, 2003, Cell Structure and Function, 28, 5, 465, 474
• An essential role for functional lysosomes in ferroptosis of cancer cells., Torii Seiji;Shintoku Ryosuke;Kubota Chisato;Yaegashi Makoto;Torii Ryoko;Sasaki Masaya;Suzuki Toshinobu;Mori Masanobu;Yoshimoto Yuhei;Takeuchi Toshiyuki;Yamada Keiichi, 12 Jan. 2016, The Biochemical journal, 473, 6

  DOI
• The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells., Torii Seiji;Kubota Chisato;Saito Naoya;Kawano Ayumi;Hou Ni;Kobayashi Masaki;Torii Ryoko;Hosaka Masahiro;Kitamura Tadahiro;Takeuchi Toshiyuki;Gomi Hiroshi, 26 Feb. 2018, The Journal of biological chemistry, 293, 16

  DOI
• Culture in 10% O2 enhances the production of active hormones in neuro-endocrine cells by up-regulating the expression of processing enzymes., Sato Eri;Maeda Yoshinori;Sato Yui;Hinata Airi;Gomi Hiroshi;Koga Daisuke;Torii Seiji;Watanabe Tsuyoshi;Hosaka Masahiro, 12 Mar. 2019, The Biochemical journal, 476, 5, 827, 842

  DOI
• ニトロキシドTEMPOは飛行して遠隔のフェロトーシスを阻害する, ;;;;;;, Oct. 2023, 96回, [1P
• Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene., Yasui Tadashi;Mashiko Mutsumi;Obi Akihiro;Mori Hiroyuki;Ito-Murata Moeko;Hayakawa Hiroki;Kikuchi Shota;Hosaka Masahiro;Kubota Chisato;Torii Seiji;Gomi Hiroshi, Dec. 2023, Histochemistry and cell biology, 161, 3

  DOI
• Phogrin Regulates High-Fat Diet-Induced Compensatory Pancreatic β-Cell Growth by Switching Binding Partners., Kubota Chisato;Torii Ryoko;Hosaka Masahiro;Takeuchi Toshiyuki;Gomi Hiroshi;Torii Seiji, Jan. 2024, Nutrients, 16, 1

  DOI
• アラキドン酸リポキシゲナーゼALOX15のフェロトーシス感受性制御機構の解明, 鳥居 征司, Mar. 2024, 58, 44
• ニトロキシドTEMPOは飛行して遠隔のフェロトーシスを阻害する, ;;;;;;, Oct. 2023, 96回, [1P
• 急性期褥瘡におけるフェロトーシス制御機構と新規治療への応用, ;;;;;;;;;;, Aug. 2024, 74, 3, 244

MISC

• Metabolic change affects susceptibility to ferroptosis in cancer cells, Seiji Torii , Chisato Kubota, Sep. 2019
• 分泌顆粒蛋白質フォグリンによる膵β細胞増殖の制御, 久保田知里、竹内利行、小林雅樹、北村忠弘、鳥居征司, Aug. 2019, The Kitakanto Medical Journal
• 化学療法における食品成分の影響について　フェロトーシスと含硫化合物, 永井聖也、瀧川雄太、鳥居征司、輿石一郎, Aug. 2019, The Kitakanto Medical Journal
• The secretory granule protein phogrin connects insulin secretion and signaling in pancreatic beta cells, Chisato Kubota, Naoya Saito, Ayumi Kawano, Toshiyuki Takeuchi, Masaki Kobayashi, Tadahiro Kitamura, Masahiro Hosaka, Hiroshi Gomi, and Seiji Torii, Sep. 2018
• Lipid peroxide accumulation enhances iron-dependent cell death ferroptosis in cancer cells, Seiji Torii, Sep. 2018
• Increased lipid peroxides in membranes contribute to ferroptosis in cancer cells, Chisato Kubota, Ryosuke Shintoku, Yuta Takigawa, Keiichi Yamada, Yuhei Yoshimoto, Toshiyuki Takeuchi, Ichiro Koshiishi, and Seiji Torii, Dec. 2017
• がん細胞の鉄依存性細胞死を誘導する酸化脂質の生成と拡がり, 神徳亮介、久保田知里、好本裕平、鳥居征司, Aug. 2017, The Kitakanto Medical Journal
• 膵β細胞におけるIA2の増殖機能阻害蛋白質の同定, 鳥居征司, Feb. 2017
• 膵β細胞におけるインスリン分解機序の追跡, Sep. 2020
• 低分子化合物によるフェロトーシス感受性の調節, Nov. 2021
• 高用量トレミフェン併用術前化学療法第2相試験最終報告, 藤澤 知巳,平方 智子,宮本 健志,柳田 康弘,木村 盛彦,桑野 博行,竹内 利之,穂坂 正博,鳥居 征司, May 2012, 日本乳癌学会総会プログラム抄録集, 20回, 462, 462
• Structure-Activity Relationship of Cytotoxic Cyclic Peptide Sansalvamide A, Hiromasa Ueno,Keiichi Yamada,Tomomi Fujisawa,Seiji Torii,Masahiro Hosaka,Hiroyuki Oku,Toshiyuki Takeuchi,Ryoichi Katakai, 2008, Peptide Scienece, 2007, 281, 284
• インスリン顆粒の開口放出とグラニュフィリン(Granuphilin)., 鳥居 征司,泉 哲郎, 2003, 23-27
• インスリン分泌顆粒開口放出の分子機序, 河西和雄,鳥居 征司,泉哲郎, 2003, 17, 597, 603
• PML bodyと細胞死, 鳥居 征司, 2000, 37/,438-444

Books etc

• 分子糖尿病学の進歩 2003, Contributor, 2003
• 糖尿病学 2010, 2010

Presentations

• The nitroxide radical TEMPO prevents ferroptosis and neuronal cell death in an airborne manner, 鳥居 征司,　水野 寛之, 久保田 知里,　瀧川 雄太, 神徳 亮介, 好本 裕平, 輿石 一郎, 第96回生化学会大会, 31 Oct. 2023
• 2,2,6,6-テトラメチルピペリジン-1-オキシル(TEMPO)の 揮発投与によるフェロトーシス阻害及び脳保護効果, 水野 寛之, 久保田 知里, 瀧川 裕太, 神徳 亮介, 金澤 雅人, 輿石 一郎, 好本 裕平, 鳥居 征司, 第81回日本脳神経外科学会学術総会, Sep. 2022
• 2,2,6,6-テトラメチルピペリジン-1-オキシルの揮発投与による脳保護効果, 水野 寛之, 神徳 亮介, 好本 裕平, 鳥居 征司, 第22回日本脳神経血管内治療学会 関東地方学術集会, Sep. 2022
• 2,2,6,6-Tetramethylpiperidine-1-oxyl acts as a volatile inhibitor of ferroptosis and neurological injury, Hiroyuki Mizuno, Chosato Kubota, Yuta Takigawa, Ryosuke Shintoku, Masato Kanazawa, Yuhei Yoshimoto, Ichiro Koshiishi, Seiji Torii, 16th Congress of World Federation of Interventional and Therapeutic Neuroradiology, Aug. 2022
• 2,2,6,6-テトラメチルピペリジンN-オキシルの揮発投与により虚血性神経細胞死は抑制される, 久保田 知里, 水野 寛之, 瀧川 裕太, 神徳 亮介, 輿石 一郎, 好本 裕平, 鳥居 征司, 2022年度日本生化学会関東支部例会, Jun. 2022
• 癌細胞のフェロトーシス感受性を薬剤で調節する, 建部 貴輝、久保田 知里、矢山 萌、神徳 亮介、水野 寛之、大日方 英、鳥居 征司, 2021年度日本生化学会関東支部例会, Jun. 2021
• 低分子化合物によるフェロトーシス感受性の調節, 鳥居 征司、 建部 貴輝, 矢山 萌, 神徳 亮介,　水野 寛之, 大日方 英、久保田 知里, 第９４回日本生化学会大会, Nov. 2021
• ALOXによる酸化ストレス抵抗性制御, 富田 和男, 桑原 義和, 鳥居 征司, 五十嵐 健人, 髙 裕子, 長澤 大成, 田中 康一, 北中 純一, 北中 順惠, 栗政 明弘, 西谷 佳, 西山 信好, 竹村 基彦, 佐藤 友昭, 第73回日本薬理学会西南部会, Nov. 2020, Nov. 2020, Domestic conference
• SecretograninⅢジーントラップマウスにおけるLacZ遺伝子発現パターンの解析, 五味浩司、安井禎、日當愛梨、鳥居征司、穂坂正博, 第163回日本獣医学会学術集会, Sep. 2020, Sep. 2020, Domestic conference
• 膵β細胞におけるインスリン分解機序の追跡, 鳥居 征司、Hou Ni、久保田 知里、竹内 利行, 第93回日本生化学会大会, Sep. 2020, Sep. 2020, Domestic conference
• 鉄依存性細胞死フェロトーシスに対する感受性を解析する, 久保田知里,鳥居征司, 第18回生体機能研究会, Jul. 2019, Jul. 2019, Domestic conference
• 第二世代抗精神病薬オランザピンは、副作用としてProinsulinの適切なジスルフィド結合形成を阻害し糖尿病を誘発する, 蜷川暁,岡田徹也,梅澤元,石川時郎,鳥居征司,Robert Mackin,今見考志,石濱泰,長嶺敬彦,森和俊, 第92回日本生化学会大会, Sep. 2019, Sep. 2019, Domestic conference
• がん細胞におけるフェロトーシス誘導の感受性機構, 鳥居征司,久保田知里, 第92回日本生化学会大会, Sep. 2019, Sep. 2019, Domestic conference
• 分泌顆粒蛋白質フォグリンによる膵β細胞増殖の制御, 久保田知里,竹内利行,小林雅樹,北村忠弘,鳥居征司, 北関東医学会第66回総会, Sep. 2019, Sep. 2019, Domestic conference
• フェロトーシスと含硫化合物, 永井聖也,瀧川雄太,鳥居征司,輿石一郎, 北関東医学会第66回総会, Sep. 2019, Sep. 2019, Domestic conference
• 過酸化脂質の蓄積が癌細胞のフェロトーシスを増進する, 鳥居征司, 第77回日本癌学会学術集会, Sep. 2018, Sep. 2018
• 第二世代抗精神病薬オランザピンがインスリン分泌不全を引き起こし、糖尿病を誘起する分子メカニズムの解析, 蜷川暁,岡田徹也,今見考志,梅澤元,石川時郎,鳥居征司,Robert Mackin,石濱泰,長嶺敬彦,森和俊, 第91回日本生化学会大会, Sep. 2018, Sep. 2018, Domestic conference
• 分泌顆粒蛋白質フォグリンによるインスリン分泌とシグナルの連結機構, 久保田知里,斎藤直也,河野あゆみ,竹内利行,小林雅樹,北村忠弘,穂坂正博,五味浩司,鳥居征司, 第91回日本生化学会大会, Sep. 2018, Sep. 2018, Domestic conference
• VAMP7 regulates autophagosome formation by supporting Atg9a functions in pancreatic β-cells, 青柳共太,板倉誠,福富俊之,西脇知世乃,中道洋子,鳥居征司,牧山智彦,原田彰宏,今泉美佳, 第91回日本生化学会大会, Sep. 2018, Sep. 2018, Domestic conference
• イヌ口腔腺における Rabおよび SNAREタンパク質の発現解析, 五味浩司,大澤裕美,宇野理恵,安井禎,鳥居征司,穂坂正博,月瀬東, 第161回日本獣医学会学術集会, Sep. 2018, Sep. 2018, Domestic conference
• 鉄依存性細胞死フェロトーシスの解析, 久保田知里,神徳亮介,瀧川雄太,山田圭一,輿石一郎,鳥居征司, 第17回生体機能研究会, Jul. 2018, Jul. 2018, Domestic conference
• The secretory granule-resident pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β-cells., Torii S, Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13), Oct. 2018, Oct. 2018, English, International conference
• 分泌顆粒膜タンパク質フォグリンは膵β細胞の増殖を制御する, 第５１回日本糖尿病学会, 2008
• A secretory granule-resident protein-tyrosine phosphatase phogrin regulates autocrine insulin signaling in pancreatic β-cells, 8th International protein phosphatase conference, 2008
• 酸化ストレスによる神経細胞死とオートファジー, 第８回生体機能研究会, 2009
• 酸化ストレス性神経細胞死に対するオートファジーの関わり, 第８２回日本生化学会, 2009
• A protein-tyrosine phosphatase phogrin regulates autocrine insulin signaling through direct interaction with insulin receptor, 49th Annual meeting -The American Society for Cell Biology, 2009
• Implication of constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative cell death, 第６２回日本細胞生物学会, 2010
• 分泌顆粒膜タンパク質Phogrinはグルコース応答性の膵ベータ細胞増殖を制御する, 第６０回日本細胞生物学会, 2008
• Basal autophagy regulates oxidative stress-associated cell death in neuronal cells, 9th International protein phosphatase conference, 2011
• 細胞障害活性ペプチドSansalvamide Aの構造活性相関, 第４４回日本ペプチド学会ペプチド討論会, 2007
• 分泌顆粒局在RPTPフォグリンの膵β細胞における生理機能, 基生研研究会, 2008
• Preferential release of newly generated insulin assessed by a multi-labeling reporter system, 2012
• 虚血ストレス下におけるMKP-1の発現上昇及びERKの発現調節を介したその役割, ？ 第24回日本脳循環代謝学会, 2012
• Exocytosis-coupled interaction of insulin receptor and secretory granule-resident PTP phogrin allows for autocrine insulin signaling in pancreatic beta cells, 10th International Conference on Protein Phosphatase, 2013
• 内分泌細胞の分泌顆粒形成におけるグラニンタンパク質の役割, 第85回日本生化学会大会, 2012
• Revealing mechanisms of mitogen activated protein kinase phosphatase (MKP-1) up-regulation under ischemic stress, 42th Annual meeting of Society for Neuroscience, 2012
• マルチタグ・ラベリング法によるインスリン分泌機構の解析, 第３０回日本内分泌学会内分泌代謝学サマーセミナー, 2012
• ラット腸管内分泌細胞におけるIA2チロシンホスファターゼ分子群の発現様式, 第86回日本生化学会大会, 2013
• インスリン分泌における顆粒膜蛋白質フォグリンとインスリン受容体の結合は、膵β細胞のオートクライン増殖シグナルに必要である, 第57回日本糖尿病学会年次学術集会, 2014
• 鉄依存性細胞死フェロトーシスにリソソーム機能が関与する, 第２３回日本Cell Death学会学術集会, 2014
• がん細胞の鉄依存性細胞死を誘導する酸化脂質の生成と拡がり, 北関東医学会第64回総会, 2017
• Lipid peroxide accumulation enhances iron-dependent cell death by anti-tumor drugs., The 4th International Symposium of Gunma University Medical Innovation, 2017
• 鉄依存性細胞死フェロトーシスにおける膜脂質過酸化, 生命科学系学会合同年次集会ConBio2017, 2017
• Reactive oxygen species-generating activity in lysosomes contributes to an iron-dependent form of cell death, 第５８回日本神経化学会, 2015
• がん細胞に新規細胞死フェロトーシスを促す鉄依存性活性酸素種の解析, 日本ケミカルバイオロジー学会 第11回年会, 2016
• ニワトリ内分泌器官におけるセクレトグラニンIIIの発現解析, 159回 日本獣医学会学術集会, 2016
• 鉄依存性細胞死に感受性を示す癌細胞のレドックス機構, 第89回日本生化学会大会, 2016
• Local reactive oxygen species generation and lipid peroxidation are involved in ferroptosis of cancer cells, 3rd International Symposium of Gunma University Medical Innovation, 2016
• A secretory granule-resident protein-tyrosine phosphatase phogrin regulates autocrine insulin signaling in pancreatic β-cells, 8th International protein phosphatase conference, 2008
• A protein-tyrosine phosphatase phogrin regulates autocrine insulin signaling through direct interaction with insulin receptor, 49th Annual meeting -The American Society for Cell Biology, 2009
• Basal autophagy regulates oxidative stress-associated cell death in neuronal cells, 9th International protein phosphatase conference, 2011
• Exocytosis-coupled interaction of insulin receptor and secretory granule-resident PTP phogrin allows for autocrine insulin signaling in pancreatic beta cells, 10th International Conference on Protein Phosphatase, 2013
• Revealing mechanisms of mitogen activated protein kinase phosphatase (MKP-1) up-regulation under ischemic stress, 42th Annual meeting of Society for Neuroscience, 2012
• Lipid peroxide accumulation enhances iron-dependent cell death by anti-tumor drugs., The 4th International Symposium of Gunma University Medical Innovation, 2017
• Local reactive oxygen species generation and lipid peroxidation are involved in ferroptosis of cancer cells, 3rd International Symposium of Gunma University Medical Innovation, 2016

Research Projects

• Apr. 2021, Mar. 2022, Principal investigator
• Apr. 2020, Mar. 2021, Principal investigator
• Functional analysis of phogrin using aged mice., Apr. 2021, Mar. 2022, Principal investigator
• Functional analysis of phogrin using aged mice, Apr. 2020, Mar. 2021, Principal investigator

Social Contribution

Social Contribution

• 食品科学特論, Nov. 2020　(Target:　Graduate students, Teachers, Researchers, General)