Researcher Profile and Settings

Researcher

• Name

  KONNO Ayumu

Profile and Settings

• Name

  Konno, Ayumu

Alternate Names

• Konno, Ayumu

Website

• URI

  http://synapse.dept.med.gunma-u.ac.jp/

Education

• Apr. 2003, Mar. 2008
• Apr. 1999, Mar. 2003, Tohoku University, Faculty of Agriculture, Department of Applied Biological Chemistry

Association Memberships

• 日本神経科学学会
• 日本生理学会
• 日本生化学会
• 日本農芸化学会
• 日本糖質学会

Research Experience

• Apr. 2009, Mar. 2011
• Aug. 2016, 9999
• Apr. 2011, Jul. 2016
• Mar. 2008, Mar. 2008, Tohoku University, Graduate School of Life Sciences
• Apr. 2006, Mar. 2008, 東北大学 生命科学研究科, 学術振興会特別研究員（ＤＣ２）
• Apr. 2008, Mar. 2009, 東北大学 学際科学国際高等研究センター, ポスドク

Research Activities

Research Areas

• Life sciences, Applied biochemistry
• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general

Research Interests

• AAV
• Adeno-associated virus
• チャネルロドプシン
• ウイルスベクター
• 神経科学
• 脳プロ
• 包括脳ネットワーク

Published Papers

• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice., Kengo Inada, Mitsue Hagihara, Kazuko Tsujimoto, Takaya Abe, Ayumu Konno, Hirokazu Hirai, Hiroshi Kiyonari, Kazunari Miyamichi, 12 Apr. 2022, Neuron

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation, Erika Ueda, Tomoko Ohta, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, Takahiro Seki, 05 Apr. 2022, Cells, 11, 7, 1230, 1230

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells., Hirokazu Hirai, Yuuki Fukai, Ayumu Konno, Nobutake Hosoi, 26 Feb. 2022, Cerebellum (London, England), Scientific journal

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+ -activated large-conductance K + channels and motor coordination, Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hiroyuki Yasui, Mika Kawachi, Takuro Horii, Yasunori Matsuzaki, Izuho Hatada, Hirokazu Hirai, 15 Feb. 2022, Proceedings of the National Academy of Sciences, 119, 7, Scientific journal

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating, Akinobu Suzuki, Sakurako Kosugi, Emi Murayama, Eri Sasakawa, Noriaki Ohkawa, Ayumu Konno, Hirokazu Hirai, Kaoru Inokuchi, Jan. 2022, Nature Communication
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury, Ryo Kawakami, Miki Matsui, Ayumu Konno, et al., Hirokazu Hirai, Masahiko Kurabayashi, Tatsuya Iso, 09 Dec. 2021, The Journal of Pathology, 255, 4, 362, 373, Scientific journal

  DOI
• Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia., Tomoko Ohta, Yuri Morikawa, Masahiro Sato, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, Takahiro Seki, Sep. 2021, Experimental neurology, 343, 113791, 113791, Scientific journal

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Putri T. Radhiyanti , Ayumu Konno , Yasunori Matsuzaki , Hirokazu Hirai, Jun. 2021, Neuroscience Letters, 756, 135956, 135956, Scientific journal

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia, Hiroyuki Yasui, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai, May 2021, Neuroscience, 462, 328, 336, Scientific journal

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice, Hisako Sugimoto, Takuro Horii, Jun-Na Hirota, Yoshitake Sano, Yo Shinoda, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Hajime Hirase, Izuho Hatada, Teiichi Furuichi, Tetsushi Sadakata, Mar. 2021, Molecular Brain, 14, 1, 52, 52, Scientific journal

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter, Chiaki Hoshino*, Ayumu Konno*, (*Contributed equally to this work), Nobutake Hosoi, Ryosuke Kaneko, Ryo Mukai, Junichi Nakai, Hirokazu Hirai, Feb. 2021, Molecular Brain, 14, 1, 33, 33, Scientific journal

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Masashi Watanave; Chiaki Hoshino; Ayumu Konno; Yumi Fukuzaki; Yasunori Matsuzaki; Tohru Ishitani; Hirokazu Hirai, Jan. 2019, Neurobiology of disease, 121, 263, 273, Scientific journal

  DOI
• UV Irradiation Promotes the Accumulation of Triglyceride in Lipomyces lipofer, Ayumu Konno*; Yoshihisa Suzuki; Tomohisa Ogawa; Tetsuo Taniuchi (*corresponding author), Nov. 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73, 11, 2474, 2477, Scientific journal

  DOI
• Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants, Ayumu Konno; Shintarou Yonemaru; Atsushi Kitagawa; Koji Muramoto; Tsuyoshi Shirai; Tomohisa Ogawa, Feb. 2010, BMC EVOLUTIONARY BIOLOGY, 10, 43, Scientific journal

  DOI
• Reconstruction of a probable ancestral form of conger eel galectins revealed their rapid adaptive evolution process for specific carbohydrate recognition, Ayumu Konno; Tomohisa Ogawa; Tsuyoshi Shirai; Koji Muramoto, Nov. 2007, MOLECULAR BIOLOGY AND EVOLUTION, 24, 11, 2504, 2514, Scientific journal

  DOI
• In vitro evolutionary thermostabilization of congerin II: A limited reproduction of natural protein evolution by artificial selection pressure, C Shionyu-Mitsuyama; Y Ito; A Konno; Y Miwa; T Ogawa; K Muramoto; T Shirai, Mar. 2005, JOURNAL OF MOLECULAR BIOLOGY, 347, 2, 385, 397, Scientific journal

  DOI
• Ancestral protein reconstruction as a new field in protein engineering, Ayumu Konno; Tomohisa Ogawa; Tsuyoshi Shirai, 2010, Ribosomal Proteins and Protein Engineering: Design, Selection and Applications, 65, 90, In book
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Akira Iizuka; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Jul. 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889, Scientific journal

  DOI
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia, Yusuke Sawada; Ayumu Konno; Jun Nagaoka; Hirokazu Hirai, Jun. 2016, SCIENTIFIC REPORTS, 6, 27758, Scientific journal

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Toshihiro Yanai; Aya Kurosawa; Yoshiaki Nikaido; Nozomi Nakajima; Tamio Saito; Hiroyuki Osada; Ayumu Konno; Hirokazu Hirai; Shigeki Takeda, Jul. 2016, GENES TO CELLS, 21, 7, 717, 727, Scientific journal

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Mamiko Suzuki; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry K. Y. Chan; Hirokazu Hirai, Nov. 2016, PLOS ONE, 11, 11, e0164202, Scientific journal

  DOI
• FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype, Jason Arsenault; Shervin Gholizadeh; Yosuke Niibori; Laura K. Pacey; Sebok K. Halder; Enea Koxhioni; Ayumu Konno; Hirokazu Hirai; David R. Hampson, Dec. 2016, HUMAN GENE THERAPY, 27, 12, 982, 996, Scientific journal

  DOI
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain, Hiromu Monai; Masamichi Ohkura; Mika Tanaka; Yuki Oe; Ayumu Konno; Hirokazu Hirai; Katsuhiko Mikoshiba; Shigeyoshi Itohara; Junichi Nakai; Youichi Iwai; Hajime Hirase, Mar. 2016, NATURE COMMUNICATIONS, 7, 11100, Scientific journal

  DOI
• Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells, Masahiro Sato; Takahiro Seki; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki, Aug. 2016, GENES TO CELLS, 21, 8, 861, 873, Scientific journal

  DOI
• Evaluation of a Sindbis virus vector displaying an immunoglobulin-binding domain: Antibody-dependent infection of neurons in living mice, Ayumu Konno*; Tatsuya Honjo; Atsushi Uchida; Toru Ishizuka; Hiromu Yawo (*corresponding author), Dec. 2011, NEUROSCIENCE RESEARCH, 71, 4, 328, 334, Scientific journal

  DOI
• Tracing Protein Evolution through Ancestral Structures of Fish Galectin, Ayumu Konno; Atsushi Kitagawa; Mizuki Watanabe; Tomohisa Ogawa; Tsuyoshi Shirai, May 2011, STRUCTURE, 19, 5, 711, 721, Scientific journal

  DOI
• Reconstraction of Ancestral Conger Eel Galectins Have Revealed Their Molecular Diversification Process by Accelerated Evolution, Konno Ayumu; Ogawa Tomohisa; Muramoto Koji; Shirai Tsuyoshi, 05 Nov. 2006, Peptide Science 2006, 138, 139, International conference proceedings
• Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells, Ayumu Konno; Anton N. Shuvaev; Noriko Miyake; Koichi Miyake; Akira Iizuka; Serina Matsuura; Fathul Huda; Kazuhiro Nakamura; Shigeru Yanagi; Takashi Shimada; Hirokazu Hirai, Feb. 2014, CEREBELLUM, 13, 1, 29, 41, Scientific journal

  DOI
• One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice, H. Saida; Y. Matsuzaki; K. Takayama; A. Iizuka; A. Konno; S. Yanagi; H. Hirai, Sep. 2014, GENE THERAPY, 21, 9, 820, 827, Scientific journal

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Yasunori Matsuzaki; Ayumu Konno; Ryo Mukai; Fumiaki Honda; Masafumi Hirato; Yuhei Yoshimoto; Hirokazu Hirai, Apr. 2017, MOLECULAR NEUROBIOLOGY, 54, 3, 1745, 1758, Scientific journal

  DOI
• Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging, Kazuki Harada; Motoki Ito; Xiaowen Wang; Mika Tanaka; Devina Wongso; Ayumu Konno; Hirokazu Hirai; Hajime Hirase; Takashi Tsuboi; Tetsuya Kitaguchi, Aug. 2017, Scientific Reports, 7, Scientific journal

  DOI
• CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously, Tsuyoshi Hattori; Minoru Kaji; Hiroshi Ishii; Roboon Jureepon; Mika Takarada-Iemata; Hieu Minh Ta; Thuong Manh Le; Ayumu Konno; Hirokazu Hirai; Yoshitake Shiraishi; Noriyuki Ozaki; Yasuhiko Yamamoto; Hiroshi Okamoto; Shigeru Yokoyama; Haruhiro Higashida; Yasuko Kitao; Osamu Hori, Jun. 2017, GLIA, 65, 6, 974, 989, Scientific journal

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Keisuke Nitta; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Sep. 2017, Molecular Therapy - Methods and Clinical Development, 6, 159, 170, Scientific journal

  DOI
• Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA, Daiki Tatsumi; Kei Nanatani; Yuto Koike; Kiyoto Kamagata; Satoshi Takahashi; Ayumu Konno; Tadaomi Furuta; Minoru Sakurai; Nobuyuki Uozumi, Jun. 2017, BIOCHEMICAL JOURNAL, 474, 1993, 2007, Scientific journal

  DOI
• Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo, Yoichiro Shinohara; Toshinori Ohtani; Ayumu Konno; Hirokazu Hirai, Dec. 2017, Cerebellum, 16, 5-6, 913, 922, Scientific journal

  DOI
• Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments., Nobutake Hosoi; Koji Shibasaki; Mayu Hosono; Ayumu Konno; Yo Shinoda; Hiroshi Kiyonari; Kenichi Inoue; Shin-Ichi Muramatsu; Yasuki Ishizaki; Hirokazu Hirai; Teiichi Furuichi; Tetsushi Sadakata, 07 Aug. 2019, The Journal of neuroscience : the official journal of the Society for Neuroscience, 39, 32, 6339, 6353, Scientific journal

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System., Shinohara Y†; Konno A†; (†Contributed equally to this work); Nitta K; Matsuzaki Y; Yasui H; Suwa J; Hiromura K; Hirai H, Jun. 2019, Molecular Neurobiology, 56, 6, 4203, 4214, Scientific journal

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice., Matsuzaki Y; Tanaka M; Hakoda S; Masuda T; Miyata R; Konno A; Hirai H, Apr. 2019, Molecular Therapy, 27, 4, 700, 704, Scientific journal

  DOI
• Advanced CUBIC tissue clearing for whole-organ cell profiling., Katsuhiko Matsumoto; Tomoki T Mitani; Shuhei A Horiguchi; Junichi Kaneshiro; Tatsuya C Murakami; Tomoyuki Mano; Hiroshi Fujishima; Ayumu Konno; Tomonobu M Watanabe; Hirokazu Hirai; Hiroki R Ueda, Dec. 2019, Nature protocols, 14, 12, 3506, 3537, Scientific journal

  DOI
• Rapamycin activates mammalian microautophagy., Sato M; Seki T; Konno A; Hirai H; Kurauchi Y; Hisatsune A; Katsuki H, Jun. 2019, J Pharmacol Sci, 140, 2, 201, 204, Scientific journal

  DOI
• Study on the structure-activity relationship of conger eel galectins using the reconstruction of the molecular evolutionary history, 今野 歩, Mar. 2008, Doctoral thesis
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Fathul Huda; Ayumu Konno; Yasunori Matsuzaki; Hanna Goenawan; Koichi Miyake; Takashi Shimada; Hirokazu Hirai, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1, 14032, Scientific journal

  DOI
• d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production., Seki T; Sato M; Konno A; Hirai H; Kurauchi Y; Hisatsune A; Katsuki H, Oct. 2018, Molecular and Cellular Neuroscience, 93, 36, 47, Scientific journal

  DOI
• Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240., Seki T; Sato M; Kibe Y; Ohta T; Oshima M; Konno A; Hirai H; Kurauchi Y; Hisatsune A; Katsuki H, Dec. 2018, Neurobiology of Disease, 120, 34, 50, Scientific journal

  DOI
• Elavl3 is essential for the maintenance of Purkinje neuron axons., Ogawa Y; Kakumoto K; Yoshida T; Kuwako KI; Miyazaki T; Yamaguchi J; Konno A; Hata J; Uchiyama Y; Hirai H; Watanabe M; Darnell RB; Okano H; Okano HJ, Feb. 2018, Scientific Reports, 8, 1, 2722, 2722, Scientific journal

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Yasunori Matsuzaki; Ayumu Konno; Ryuta Mochizuki; Yoichiro Shinohara; Keisuke Nitta; Yukihiro Okada; Hirokazu Hirai, 05 Feb. 2018, Neuroscience Letters, 665, 182, 188, Scientific journal

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells., Takahashi N; Shuvaev AN; Konno A; Matsuzaki Y; Watanave M; Hirai H, Oct. 2017, Journal of Neurochemistry, 143, 6, 660, 670, Scientific journal

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains., Shinohara Y†; Konno A†; (†Contributed equally to this work); Takahashi N; Matsuzaki Y; Kishi S; Hirai H, Aug. 2016, PLoS ONE, 11, 11, e0164202, Scientific journal

  DOI
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB, Ayumu Konno; Hirokazu Hirai, Dec. 2020, Journal of Neuroscience Methods, 346, 108914, 108914, Scientific journal

  DOI
• Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance, Yuki Oe; Xiaowen Wang; Tommaso Patriarchi; Ayumu Konno; Katsuya Ozawa; Kazuko Yahagi; Hirokazu Hirai; Takashi Tsuboi; Tetsuya Kitaguchi; Lin Tian; Thomas J. McHugh; Hajime Hirase, Jan. 2020, Nature Communications, 11, 1, 471, 3447, Scientific journal

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone‐mediated autophagy in cerebellar neurons, Masahiro Sato; Tomoko Ohta; Yuri Morikawa; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki; Takahiro Seki, 09 Aug. 2020, Neuropathology and Applied Neurobiology, 47, 2, 198, 209, Scientific journal

  DOI
• Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy, Masahiro Sato; Erika Ueda; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki; Takahiro Seki, Jul. 2020, Biochemical and Biophysical Research Communications, 528, 1, 199, 205, Scientific journal

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia., Hiroyuki Yasui; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, May 2021, Neuroscience, 462, 328, 336, Scientific journal

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Huda, Fathul;Konno, Ayumu;Matsuzaki, Yasunori;Goenawan, Hanna;Miyake, Koichi;Shimada, Takashi;Hirai, Hirokazu, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1

  DOI
• Evaluation of a Sindbis virus vector displaying an immunoglobulin-binding domain: Antibody-dependent infection of neurons in living mice, Konno, Ayumu;Honjo, Tatsuya;Uchida, Atsushi;Ishizuka, Toru;Yawo, Hiromu, 2011, NEUROSCIENCE RESEARCH, 71, 4, 328, 334

  DOI
• Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells, Konno, Ayumu;Shuvaev, Anton N.;Miyake, Noriko;Miyake, Koichi;Iizuka, Akira;Matsuura, Serina;Huda, Fathul;Nakamura, Kazuhiro;Yanagi, Shigeru;Shimada, Takashi;Hirai, Hirokazu, 2014, CEREBELLUM, 13, 1, 29, 41

  DOI
• Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA, Tatsumi, Daiki;Nanatani, Kei;Koike, Yuto;Kamagata, Kiyoto;Takahashi, Satoshi;Konno, Ayumu;Furuta, Tadaomi;Sakurai, Minoru;Uozumi, Nobuyuki, 2017, BIOCHEMICAL JOURNAL, 474, 1993, 2007

  DOI
• Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging, Harada, Kazuki;Ito, Motoki;Wang, Xiaowen;Tanaka, Mika;Wongso, Devina;Konno, Ayumu;Hirai, Hirokazu;Hirase, Hajime;Tsuboi, Takashi;Kitaguchi, Tetsuya, 2017, SCIENTIFIC REPORTS, 7

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Nitta, Keisuke;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2017, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 6, 159, 170

  DOI
• Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo, Shinohara, Yoichiro;Ohtani, Toshinori;Konno, Ayumu;Hirai, Hirokazu, 2017, CEREBELLUM, 16, 5-6, 913, 922

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells, Takahashi, Nobutaka;Shuvaev, Anton N.;Konno, Ayumu;Matsuzaki, Yasunori;Watanave, Masashi;Hirai, Hirokazu, 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 660, 670

  DOI
• Elavl3 is essential for the maintenance of Purkinje neuron axons, Ogawa, Yuki;Kakumoto, Kyoko;Yoshida, Tetsu;Kuwako, Ken-ichiro;Miyazaki, Taisuke;Yamaguchi, Junji;Konno, Ayumu;Hata, Junichi;Uchiyama, Yasuo;Hirai, Hirokazu;Watanabe, Masahiko;Darnell, Robert B.;Okano, Hideyuki;Okano, Hirotaka James, 2018, SCIENTIFIC REPORTS, 8

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Matsuzaki, Yasunori;Konno, Ayumu;Mochizuki, Ryuta;Shinohara, Yoichiro;Nitta, Keisuke;Okada, Yukihiro;Hirai, Hirokazu, 2018, NEUROSCIENCE LETTERS, 665, 182, 188

  DOI
• Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240, Seki, Takahiro;Sato, Masahiro;Kibe, Yuki;Ohta, Tomoko;Oshima, Mutsumi;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2018, NEUROBIOLOGY OF DISEASE, 120, 34, 50

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor a function mitigates spinocerebellar ataxia type 3 pathology, Watanave, Masashi;Hoshino, Chiaki;Konno, Ayumu;Fukuzaki, Yumi;Matsuzaki, Yasunori;Ishitani, Tohru;Hirai, Hirokazu, 2019, NEUROBIOLOGY OF DISEASE, 121, 263, 273

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice, Matsuzaki, Yasunori;Tanaka, Masami;Hakoda, Sachiko;Masuda, Tatsuki;Miyata, Ryota;Konno, Ayumu;Hirai, Hirokazu, 2019, MOLECULAR THERAPY, 27, 4, 700, 704

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System, Shinohara, Yoichiro;Konno, Ayumu;Nitta, Keisuke;Matsuzaki, Yasunori;Yasui, Hiroyuki;Suwa, Junya;Hiromura, Keiju;Hirai, Hirokazu, 2019, MOLECULAR NEUROBIOLOGY, 56, 6, 4203, 4214

  DOI
• Rapamycin activates mammalian microautophagy, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2019, JOURNAL OF PHARMACOLOGICAL SCIENCES, 140, 2, 201, 204

  DOI
• Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments, Hosoi, Nobutake;Shibasaki, Koji;Hosono, Mayu;Konno, Ayumu;Shinoda, Yo;Kiyonari, Hiroshi;Inoue, Kenichi;Muramatsu, EShin-ichi;Ishizaki, Yasuki;Hirai, Hirokazu;Furuichi, Telichi;Sadakata, Tetsushi, 2019, JOURNAL OF NEUROSCIENCE, 39, 32, 6339, 6353

  DOI
• Advanced CUBIC tissue clearing for whole-organ cell profiling, Matsumoto, Katsuhiko;Mitani, Tomoki T.;Horiguchi, Shuhei A.;Kaneshiro, Junichi;Murakami, Tatsuya C.;Mano, Tomoyuki;Fujishima, Hiroshi;Konno, Ayumu;Watanabe, Tomonobu M.;Hirai, Hirokazu;Ueda, Hiroki R., 2019, NATURE PROTOCOLS, 14, 12, 3506, 3537

  DOI
• Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy, Sato, Masahiro;Ueda, Erika;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi;Seki, Takahiro, 2020, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 528, 1, 199, 205

  DOI
• Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance, Oe, Yuki;Wang, Xiaowen;Patriarchi, Tommaso;Konno, Ayumu;Ozawa, Katsuya;Yahagi, Kazuko;Hirai, Hirokazu;Tian, Lin;McHugh, Thomas J.;Hirase, Hajime, 2020, NATURE COMMUNICATIONS, 11, 1

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons, Sato, Masahiro;Ohta, Tomoko;Morikawa, Yuri;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi;Seki, Takahiro, 2020, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

  DOI
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry;Hirai, Hirokazu, 2015, MOLECULAR THERAPY, 23, S237, S237
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain, Monai, Hiromu;Ohkura, Masamichi;Tanaka, Mika;Oe, Yuki;Konno, Ayumu;Hirai, Hirokazu;Mikoshiba, Katsuhiko;Itohara, Shigeyoshi;Nakai, Junichi;Iwai, Youichi;Hirase, Hajime, 2016, NATURE COMMUNICATIONS, 7

  DOI
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia, Sawada, Yusuke;Konno, Ayumu;Nagaoka, Jun;Hirai, Hirokazu, 2016, SCIENTIFIC REPORTS, 6

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Yanai, Toshihiro;Kurosawa, Aya;Nikaido, Yoshiaki;Nakajima, Nozomi;Saito, Tamio;Osada, Hiroyuki;Konno, Ayumu;Hirai, Hirokazu;Takeda, Shigeki, 2016, GENES TO CELLS, 21, 7, 717, 727

  DOI
• Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, GENES TO CELLS, 21, 8, 861, 873

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Iizuka, Akira;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Shinohara, Yoichiro;Konno, Ayumu;Takahashi, Nobutaka;Matsuzaki, Yasunori;Kishi, Shoji;Hirai, Hirokazu, 2016, PLOS ONE, 11, 8

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Suzuki, Mamiko;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry K. Y.;Hirai, Hirokazu, 2016, PLOS ONE, 11, 11

  DOI
• FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype, Arsenault, Jason;Gholizadeh, Shervin;Niibori, Yosuke;Pacey, Laura K.;Halder, Sebok K.;Koxhioni, Enea;Konno, Ayumu;Hirai, Hirokazu;Hampson, David R., 2016, HUMAN GENE THERAPY, 27, 12, 982, 996

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Matsuzaki, Yasunori;Konno, Ayumu;Mukai, Ryo;Honda, Fumiaki;Hirato, Masafumi;Yoshimoto, Yuhei;Hirai, Hirokazu, 2017, MOLECULAR NEUROBIOLOGY, 54, 3, 1745, 1758

  DOI
• CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously, Hattori, Tsuyoshi;Kaji, Minoru;Ishii, Hiroshi;Jureepon, Roboon;Takarada-Iemata, Mika;Hieu Minh Ta;Thuong Manh Le;Konno, Ayumu;Hirai, Hirokazu;Shiraishi, Yoshitake;Ozaki, Noriyuki;Yamamoto, Yasuhiko;Okamoto, Hiroshi;Yokoyama, Shigeru;Higashida, Haruhiro;Kitao, Yasuko;Hori, Osamu, 2017, GLIA, 65, 6, 974, 989

  DOI
• Establishment of model mice of spinocerebellar ataxia type 21 using adeno-associated viral vectors, Kibe, Yuki;Seki, Takahiro;Kurauchi, Yuki;Konno, Ayumu;Hirai, Hirokazu;Hisatsune, Akinori;Katsuki, Hiroshi, 2017, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133, 3, S207, S207
• Rapamycin activates mammalian microautophagy, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2017, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133, 3, S245, S245
• Effect of mutant TMEM240 that causes spinocerebellar ataxia 21 on neural morphology, Seki, Takahiro;Sato, Masahiro;Kibe, Yuki;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130, 3, S104, S104
• Visualization of microautophagy and chaperone-mediated autophagy in primary cultured neurons, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130, 3, S192, S192
• 神経炎症により神経細胞特異的NSEプロモーター活性が神経細胞からグリア細胞へと可逆的に変化する, ;;;, Aug. 2016, 66, 3, 245
• アデノ随伴ウイルスベクターを用いた神経細胞特異的NSEプロモーターの解析, ;;;, Aug. 2017, 67, 3, 273
• リピート病における神経変性の分子機構解明を目指して　アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, ;;;;;, Dec. 2017, 2017年度, [3PW23
• クローズアップ実験法(series 308)　ウイルスベクターの静脈投与によるマウス脳全域への遺伝子導入, ;, Mar. 2019, 37, 4, 581
• モデルマウスを用いた本態性振戦発症機序の解明, ;;;;;;;, Aug. 2018, 68, 3, 211
• マウスCNSにおけるAAV-PHP.Bの中和抗体と遺伝子発現の検討, ;;;;;, Aug. 2018, 68, 3, 211
• Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells., Konno Ayumu;Shuvaev Anton N;Miyake Noriko;Miyake Koichi;Iizuka Akira;Matsuura Serina;Huda Fathul;Nakamura Kazuhiro;Yanagi Shigeru;Shimada Takashi;Hirai Hirokazu, Cerebellum (London, England), 13, 1

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model., Huda Fathul;Konno Ayumu;Matsuzaki Yasunori;Goenawan Hanna;Miyake Koichi;Shimada Takashi;Hirai Hirokazu, 06 Aug. 2014, Molecular therapy. Methods & clinical development, 1

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα., Iizuka Akira;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 30 Jun. 2015, Brain structure & function, 221, 6

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors., Matsuzaki Yasunori;Konno Ayumu;Mukai Ryo;Honda Fumiaki;Hirato Masafumi;Yoshimoto Yuhei;Hirai Hirokazu, 16 Feb. 2016, Molecular neurobiology, 54, 3

  DOI
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain., Monai Hiromu;Ohkura Masamichi;Tanaka Mika;Oe Yuki;Konno Ayumu;Hirai Hirokazu;Mikoshiba Katsuhiko;Itohara Shigeyoshi;Nakai Junichi;Iwai Youichi;Hirase Hajime, 22 Mar. 2016, Nature communications, 7

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain., Yanai Toshihiro;Kurosawa Aya;Nikaido Yoshiaki;Nakajima Nozomi;Saito Tamio;Osada Hiroyuki;Konno Ayumu;Hirai Hirokazu;Takeda Shigeki, 17 May 2016, Genes to cells : devoted to molecular & cellular mechanisms, 21, 7

  DOI
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia., Sawada Yusuke;Konno Ayumu;Nagaoka Jun;Hirai Hirokazu, 13 Jun. 2016, Scientific reports, 6

  DOI
• Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells., Sato Masahiro;Seki Takahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 05 Jul. 2016, Genes to cells : devoted to molecular & cellular mechanisms, 21, 8

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains., Shinohara Yoichiro;Konno Ayumu;Takahashi Nobutaka;Matsuzaki Yasunori;Kishi Shoji;Hirai Hirokazu, 29 Aug. 2016, PloS one, 11, 8

  DOI
• FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype., Arsenault Jason;Gholizadeh Shervin;Niibori Yosuke;Pacey Laura K;Halder Sebok K;Koxhioni Enea;Konno Ayumu;Hirai Hirokazu;Hampson David R, 07 Sep. 2016, Human gene therapy, 27, 12

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice., Huda Fathul;Fan Yiping;Suzuki Mamiko;Konno Ayumu;Matsuzaki Yasunori;Takahashi Nobutaka;Chan Jerry K Y;Hirai Hirokazu, 01 Nov. 2016, PloS one, 11, 11

  DOI
• CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously., Hattori Tsuyoshi;Kaji Minoru;Ishii Hiroshi;Jureepon Roboon;Takarada-Iemata Mika;Minh Ta Hieu;Manh Le Thuong;Konno Ayumu;Hirai Hirokazu;Shiraishi Yoshitake;Ozaki Noriyuki;Yamamoto Yasuhiko;Okamoto Hiroshi;Yokoyama Shigeru;Higashida Haruhiro;Kitao Yasuko;Hori Osamu, 13 Mar. 2017, Glia, 65, 6

  DOI
• Probing native metal ion association sites through quenching of fluorophores in the nucleotide-binding domains of the ABC transporter MsbA., Tatsumi Daiki;Nanatani Kei;Koike Yuto;Kamagata Kiyoto;Takahashi Satoshi;Konno Ayumu;Furuta Tadaomi;Sakurai Minoru;Uozumi Nobuyuki, 30 May 2017, The Biochemical journal, 474, 12

  DOI
• Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo., Shinohara Yoichiro;Ohtani Toshinori;Konno Ayumu;Hirai Hirokazu, Cerebellum (London, England), 16, 5-6

  DOI
• Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging., Harada Kazuki;Ito Motoki;Wang Xiaowen;Tanaka Mika;Wongso Devina;Konno Ayumu;Hirai Hirokazu;Hirase Hajime;Tsuboi Takashi;Kitaguchi Tetsuya, 04 Aug. 2017, Scientific reports, 7, 1

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates., Nitta Keisuke;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 27 Jul. 2017, Molecular therapy. Methods & clinical development, 6

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells., Takahashi Nobutaka;Shuvaev Anton N;Konno Ayumu;Matsuzaki Yasunori;Watanave Masashi;Hirai Hirokazu, 29 Nov. 2017, Journal of neurochemistry, 143, 6

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain., Matsuzaki Yasunori;Konno Ayumu;Mochizuki Ryuta;Shinohara Yoichiro;Nitta Keisuke;Okada Yukihiro;Hirai Hirokazu, 24 Nov. 2017, Neuroscience letters, 665

  DOI
• Elavl3 is essential for the maintenance of Purkinje neuron axons., Ogawa Yuki;Kakumoto Kyoko;Yoshida Tetsu;Kuwako Ken-Ichiro;Miyazaki Taisuke;Yamaguchi Junji;Konno Ayumu;Hata Junichi;Uchiyama Yasuo;Hirai Hirokazu;Watanabe Masahiko;Darnell Robert B;Okano Hideyuki;Okano Hirotaka James, 09 Feb. 2018, Scientific reports, 8, 1

  DOI
• Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240., Seki Takahiro;Sato Masahiro;Kibe Yuki;Ohta Tomoko;Oshima Mutsumi;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 02 Sep. 2018, Neurobiology of disease, 120

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System., Shinohara Yoichiro;Konno Ayumu;Nitta Keisuke;Matsuzaki Yasunori;Yasui Hiroyuki;Suwa Junya;Hiromura Keiju;Hirai Hirokazu, 05 Oct. 2018, Molecular neurobiology, 56, 6

  DOI
• d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production., Seki Takahiro;Sato Masahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 19 Oct. 2018, Molecular and cellular neurosciences, 93

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Watanave Masashi;Hoshino Chiaki;Konno Ayumu;Fukuzaki Yumi;Matsuzaki Yasunori;Ishitani Tohru;Hirai Hirokazu, 19 Oct. 2018, Neurobiology of disease, 121

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice., Matsuzaki Yasunori;Tanaka Masami;Hakoda Sachiko;Masuda Tatsuki;Miyata Ryota;Konno Ayumu;Hirai Hirokazu, 28 Feb. 2019, Molecular therapy : the journal of the American Society of Gene Therapy, 27, 4

  DOI
• Rapamycin activates mammalian microautophagy., Sato Masahiro;Seki Takahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 24 May 2019, Journal of pharmacological sciences, 140, 2

  DOI
• Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments., Hosoi Nobutake;Shibasaki Koji;Hosono Mayu;Konno Ayumu;Shinoda Yo;Kiyonari Hiroshi;Inoue Kenichi;Muramatsu Shin-Ichi;Ishizaki Yasuki;Hirai Hirokazu;Furuichi Teiichi;Sadakata Tetsushi, 14 Jun. 2019, The Journal of neuroscience : the official journal of the Society for Neuroscience, 39, 32

  DOI
• Advanced CUBIC tissue clearing for whole-organ cell profiling., Matsumoto Katsuhiko;Mitani Tomoki T;Horiguchi Shuhei A;Kaneshiro Junichi;Murakami Tatsuya C;Mano Tomoyuki;Fujishima Hiroshi;Konno Ayumu;Watanabe Tomonobu M;Hirai Hirokazu;Ueda Hiroki R, 20 Nov. 2019, Nature protocols, 14, 12

  DOI
• Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance., Oe Yuki;Wang Xiaowen;Patriarchi Tommaso;Konno Ayumu;Ozawa Katsuya;Yahagi Kazuko;Hirai Hirokazu;Tsuboi Takashi;Kitaguchi Tetsuya;Tian Lin;McHugh Thomas J;Hirase Hajime, 24 Jan. 2020, Nature communications, 11, 1

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia., Yasui Hiroyuki;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 08 Apr. 2020, Neuroscience

  DOI
• Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy., Sato Masahiro;Ueda Erika;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, 30 May 2020, Biochemical and biophysical research communications, 528, 1

  DOI
• Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance., Oe Yuki;Wang Xiaowen;Patriarchi Tommaso;Konno Ayumu;Ozawa Katsuya;Yahagi Kazuko;Hirai Hirokazu;Tsuboi Takashi;Kitaguchi Tetsuya;Tian Lin;McHugh Thomas J;Hirase Hajime, 07 Jul. 2020, Nature communications, 11, 1

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons., Sato Masahiro;Ohta Tomoko;Morikawa Yuri;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, 28 Jul. 2020, Neuropathology and applied neurobiology

  DOI
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB., Konno Ayumu;Hirai Hirokazu, 15 Aug. 2020, Journal of neuroscience methods, 346

  DOI
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, ;;;;;;, Sep. 2019, 92回, [1T14a
• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice., Kengo Inada; Mitsue Hagihara; Kazuko Tsujimoto; Takaya Abe; Ayumu Konno; Hirokazu Hirai; Hiroshi Kiyonari; Kazunari Miyamichi, 12 Apr. 2022, Neuron, Scientific journal

  DOI
• Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation, Xiaowen Wang; Christine Delle; Antonis Asiminas; Sonam Akther; Marta Vittani; Peter Brøgger; Peter Kusk; Camilla Trang Vo; Ayumu Konno; Hirokazu Hirai; Masahiro Fukuda; Pia Weikop; Steven A Goldman; Maiken Nedergaard; Hajime Hirase, 10 Apr. 2022, Scientific journal

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation, Erika Ueda; Tomoko Ohta; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Hiroshi Katsuki; Takahiro Seki, 05 Apr. 2022, Cells, 11, 7, 1230, 1230, Scientific journal

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells., Hirokazu Hirai; Yuuki Fukai; Ayumu Konno; Nobutake Hosoi, 26 Feb. 2022, Cerebellum (London, England), Scientific journal

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca 2+ -activated large-conductance K + channels and motor coordination, Masashi Watanave; Nobutaka Takahashi; Nobutake Hosoi; Ayumu Konno; Hikaru Yamamoto; Hiroyuki Yasui; Mika Kawachi; Takuro Horii; Yasunori Matsuzaki; Izuho Hatada; Hirokazu Hirai, 15 Feb. 2022, Proceedings of the National Academy of Sciences, 119, 7, Scientific journal

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating, Akinobu Suzuki; Sakurako Kosugi; Emi Murayama; Eri Sasakawa; Noriaki Ohkawa; Ayumu Konno; Hirokazu Hirai; Kaoru Inokuchi, Jan. 2022, Nature Communications, Scientific journal

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury, Ryo Kawakami; Miki Matsui; Ayumu Konno; Ryosuke Kaneko; Shreya Shrestha; Suman Shrestha; Hiroaki Sunaga; Hirofumi Hanaoka; Sawako Goto; Michihiro Hosojima; Hideyuki Kabasawa; Masaru Obokata; Norimichi Koitabashi; Hiroki Matsui; Tsutomu Sasaki; Akihiko Saito; Motoko Yanagita; Hirokazu Hirai; Masahiko Kurabayashi; Tatsuya Iso, 09 Dec. 2021, The Journal of Pathology, Scientific journal

  DOI
• Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia., Tomoko Ohta; Yuri Morikawa; Masahiro Sato; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki; Takahiro Seki, Sep. 2021, Experimental neurology, 343, 113791, 113791, Scientific journal

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Putri T. Radhiyanti; Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, Jun. 2021, Neuroscience Letters, 756, 135956, 135956, Scientific journal

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice, Hisako Sugimoto; Takuro Horii; Jun-Na Hirota; Yoshitake Sano; Yo Shinoda; Ayumu Konno; Hirokazu Hirai; Yasuki Ishizaki; Hajime Hirase; Izuho Hatada; Teiichi Furuichi; Tetsushi Sadakata, Mar. 2021, Molecular Brain, 14, 1, 52, 52, Scientific journal

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter, Chiaki Hoshino; Ayumu Konno; Nobutake Hosoi; Ryosuke Kaneko; Ryo Mukai; Junichi Nakai; Hirokazu Hirai, Feb. 2021, Molecular Brain, 14, 1, 33, 33, Scientific journal

  DOI
• マウスCNSにおけるAAV-PHP.Bの中和抗体と遺伝子発現の検討, 篠原 洋一郎; 今野 歩; 諏訪 絢也; 廣村 桂樹; 秋山 英雄; 平井 宏和, Aug. 2018, 68, 3, 211, 212
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating, Suzuki, Akinobu;Kosugi, Sakurako;Murayama, Emi;Sasakawa, Eri;Ohkawa, Noriaki;Konno, Ayumu;Hirai, Hirokazu;Inokuchi, Kaoru, 2022, NATURE COMMUNICATIONS, 13, 1

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C gamma Translocation in Cerebellar Purkinje Cells, Hirai, Hirokazu;Fukai, Yuuki;Konno, Ayumu;Hosoi, Nobutake, 2022, CEREBELLUM, 21, 5, 776, 783

  DOI
• Protein kinase C gamma in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination, Watanave, Masashi;Takahashi, Nobutaka;Hosoi, Nobutake;Konno, Ayumu;Yamamoto, Hikaru;Yasui, Hiroyuki;Kawachi, Mika;Horii, Takuro;Matsuzaki, Yasunori;Hatada, Izuho;Hirai, Hirokazu, 2022, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, 7

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation, Ueda, Erika;Ohta, Tomoko;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Katsuki, Hiroshi;Seki, Takahiro, 2022, CELLS, 11, 7

  DOI
• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice, Inada, Kengo;Hagihara, Mitsue;Tsujimoto, Kazuko;Abe, Takaya;Konno, Ayumu;Hirai, Hirokazu;Kiyonari, Hiroshi;Miyamichi, Kazunari, 2022, NEURON, 110, 12, 2009, +

  DOI
• Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation, Tokuyama, Takeshi;Uosaki, Hideki;Sugiura, Ayumu;Nishitai, Gen;Takeda, Keisuke;Nagashima, Shun;Shiiba, Isshin;Ito, Naoki;Amo, Taku;Mohri, Satoshi;Nishimura, Akiyuki;Nishida, Motohiro;Konno, Ayumu;Hirai, Hirokazu;Ishido, Satoshi;Yoshizawa, Takahiro;Shindo, Takayuki;Takada, Shingo;Kinugawa, Shintaro;Inatome, Ryoko;Yanagi, Shigeru, 2022, ISCIENCE, 25, 7

  DOI
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, ;;;;;;, Sep. 2019, 92回, [1T14a
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter., Hoshino Chiaki;Konno Ayumu;Hosoi Nobutake;Kaneko Ryosuke;Mukai Ryo;Nakai Junichi;Hirai Hirokazu, Feb. 2021, Molecular brain, 14, 1

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice., Sugimoto Hisako;Horii Takuro;Hirota Jun-Na;Sano Yoshitake;Shinoda Yo;Konno Ayumu;Hirai Hirokazu;Ishizaki Yasuki;Hirase Hajime;Hatada Izuho;Furuichi Teiichi;Sadakata Tetsushi, Mar. 2021, Molecular brain, 14, 1

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB., Radhiyanti Putri T;Konno Ayumu;Matsuzaki Yasunori;Hirai Hirokazu, May 2021, Neuroscience letters, 756

  DOI
• Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia., Ohta Tomoko;Morikawa Yuri;Sato Masahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, Jun. 2021, Experimental neurology, 343

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury., Kawakami Ryo;Matsui Miki;Konno Ayumu;Kaneko Ryosuke;Shrestha Shreya;Shrestha Suman;Sunaga Hiroaki;Hanaoka Hirofumi;Goto Sawako;Hosojima Michihiro;Kabasawa Hideyuki;Obokata Masaru;Koitabashi Norimichi;Matsui Hiroki;Sasaki Tsutomu;Saito Akihiko;Yanagita Motoko;Hirai Hirokazu;Kurabayashi Masahiko;Iso Tatsuya, Sep. 2021, The Journal of pathology, 255, 4

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating., Suzuki Akinobu;Kosugi Sakurako;Murayama Emi;Sasakawa Eri;Ohkawa Noriaki;Konno Ayumu;Hirai Hirokazu;Inokuchi Kaoru, Jan. 2022, Nature communications, 13, 1

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination., Watanave Masashi;Takahashi Nobutaka;Hosoi Nobutake;Konno Ayumu;Yamamoto Hikaru;Yasui Hiroyuki;Kawachi Mika;Horii Takuro;Matsuzaki Yasunori;Hatada Izuho;Hirai Hirokazu, Proceedings of the National Academy of Sciences of the United States of America, 119, 7

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells., Hirai Hirokazu;Fukai Yuuki;Konno Ayumu;Hosoi Nobutake, Feb. 2022, Cerebellum (London, England)

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation., Ueda Erika;Ohta Tomoko;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Katsuki Hiroshi;Seki Takahiro, Apr. 2022, Cells, 11, 7

  DOI
• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice., Inada Kengo;Hagihara Mitsue;Tsujimoto Kazuko;Abe Takaya;Konno Ayumu;Hirai Hirokazu;Kiyonari Hiroshi;Miyamichi Kazunari, Apr. 2022, Neuron, 110, 12

  DOI
• Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation., Tokuyama Takeshi;Uosaki Hideki;Sugiura Ayumu;Nishitai Gen;Takeda Keisuke;Nagashima Shun;Shiiba Isshin;Ito Naoki;Amo Taku;Mohri Satoshi;Nishimura Akiyuki;Nishida Motohiro;Konno Ayumu;Hirai Hirokazu;Ishido Satoshi;Yoshizawa Takahiro;Shindo Takayuki;Takada Shingo;Kinugawa Shintaro;Inatome Ryoko;Yanagi Shigeru, Jun. 2022, iScience, 25, 7

  DOI
• 発現増強因子WPREの短鎖化がマウス脳におけるアデノ随伴ウイルスベクターによる遺伝子発現強度に及ぼす影響, ;;;;, Mar. 2022, 142年会, 28PO7
• D-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production, Seki, Takahiro;Sato, Masahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2018, MOLECULAR AND CELLULAR NEUROSCIENCE, 93, 36, 47

  DOI
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB, Konno, Ayumu;Hirai, Hirokazu, 2020, JOURNAL OF NEUROSCIENCE METHODS, 346

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter, Hoshino, Chiaki;Konno, Ayumu;Hosoi, Nobutake;Kaneko, Ryosuke;Mukai, Ryo;Nakai, Junichi;Hirai, Hirokazu, 2021, MOLECULAR BRAIN, 14, 1

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice, Sugimoto, Hisako;Horii, Takuro;Hirota, Jun-Na;Sano, Yoshitake;Shinoda, Yo;Konno, Ayumu;Hirai, Hirokazu;Ishizaki, Yasuki;Hirase, Hajime;Hatada, Izuho;Furuichi, Teiichi;Sadakata, Tetsushi, 2021, MOLECULAR BRAIN, 14, 1

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor a in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia, Yasui, Hiroyuki;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2021, NEUROSCIENCE, 462, 328, 336

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Radhiyanti, Putri T.;Konno, Ayumu;Matsuzaki, Yasunori;Hirai, Hirokazu, 2021, NEUROSCIENCE LETTERS, 756

  DOI
• Therapeutic potential of D-cysteine against in vitro and in vivo models of spinocerebellar ataxia, Ohta, Tomoko;Morikawa, Yuri;Sato, Masahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi;Seki, Takahiro, 2021, EXPERIMENTAL NEUROLOGY, 343

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury, Kawakami, Ryo;Matsui, Miki;Konno, Ayumu;Kaneko, Ryosuke;Shrestha, Shreya;Shrestha, Suman;Sunaga, Hiroaki;Hanaoka, Hirofumi;Goto, Sawako;Hosojima, Michihiro;Kabasawa, Hideyuki;Obokata, Masaru;Koitabashi, Norimichi;Matsui, Hiroki;Sasaki, Tsutomu;Saito, Akihiko;Yanagita, Motoko;Hirai, Hirokazu;Kurabayashi, Masahiko;Iso, Tatsuya, 2021, JOURNAL OF PATHOLOGY, 255, 4, 362, 373

  DOI
• Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo, Okada, Yukihiro;Hosoi, Nobutake;Matsuzaki, Yasunori;Fukai, Yuuki;Hiraga, Akito;Nakai, Junichi;Nitta, Keisuke;Shinohara, Yoichiro;Konno, Ayumu;Hirai, Hirokazu, 2022, COMMUNICATIONS BIOLOGY, 5, 1

  DOI
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers, Jin, Mingyue;Matsumoto, Sakiko;Ayaki, Takashi;Yamakado, Hodaka;Taguchi, Tomoyuki;Togawa, Natsuko;Konno, Ayumu;Hirai, Hirokazu;Nakajima, Hiroshi;Komai, Shoji;Ishida, Ryuichi;Chiba, Syuhei;Takahashi, Ryosuke;Takao, Toshifumi;Hirotsune, Shinji, 2022, NATURE COMMUNICATIONS, 13, 1

  DOI
• Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans, Murase, Shuhei;Sakitani, Naoyoshi;Maekawa, Takahiro;Yoshino, Daisuke;Takano, Kouji;Konno, Ayumu;Hirai, Hirokazu;Saito, Taku;Tanaka, Sakae;Shinohara, Keisuke;Kishi, Takuya;Yoshikawa, Yuki;Sakai, Takamasa;Ayaori, Makoto;Inanami, Hirohiko;Tomiyasu, Koji;Takashima, Atsushi;Ogata, Toru;Tsuchimochi, Hirotsugu;Sato, Shinya;Saito, Shigeyoshi;Yoshino, Kohzoh;Matsuura, Yuiko;Funamoto, Kenichi;Ochi, Hiroki;Shinohara, Masahiro;Nagao, Motoshi;Sawada, Yasuhiro, 2023, NATURE BIOMEDICAL ENGINEERING

  DOI
• Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice, Yaguchi, Kasane;Hagihara, Mitsue;Konno, Ayumu;Hirai, Hirokazu;Yukinaga, Hiroko;Miyamichi, Kazunari, 2023, PLOS ONE, 18, 5

  DOI
• A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant, Kawabata, Hayato;Konno, Ayumu;Matsuzaki, Yasunori;Hirai, Hirokazu, 2023, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 29, 81, 92

  DOI
• Astrocytic GPCR-Induced Ca²⁺ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes, Ozawa, Katsuya;Nagao, Masaki;Konno, Ayumu;Iwai, Youichi;Vittani, Marta;Kusk, Peter;Mishima, Tsuneko;Hirai, Hirokazu;Nedergaard, Maiken;Hirase, Hajime, 2023, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 17

  DOI
• 発現増強因子WPREの短鎖化がマウス脳におけるアデノ随伴ウイルスベクターによる遺伝子発現強度に及ぼす影響, ;;;;, Mar. 2022, 142年会, 28PO7
• Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation., Wang Xiaowen;Delle Christine;Asiminas Antonis;Akther Sonam;Vittani Marta;Brøgger Peter;Kusk Peter;Vo Camilla Trang;Radovanovic Tessa;Konno Ayumu;Hirai Hirokazu;Fukuda Masahiro;Weikop Pia;Goldman Steven A;Nedergaard Maiken;Hirase Hajime, Sep. 2022, Cell reports methods, 2, 10

  DOI
• Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo., Okada Yukihiro;Hosoi Nobutake;Matsuzaki Yasunori;Fukai Yuuki;Hiraga Akito;Nakai Junichi;Nitta Keisuke;Shinohara Yoichiro;Konno Ayumu;Hirai Hirokazu, Nov. 2022, Communications biology, 5, 1

  DOI
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers., Jin Mingyue;Matsumoto Sakiko;Ayaki Takashi;Yamakado Hodaka;Taguchi Tomoyuki;Togawa Natsuko;Konno Ayumu;Hirai Hirokazu;Nakajima Hiroshi;Komai Shoji;Ishida Ryuichi;Chiba Syuhei;Takahashi Ryosuke;Takao Toshifumi;Hirotsune Shinji, Nov. 2022, Nature communications, 13, 1

  DOI
• A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant., Kawabata Hayato;Konno Ayumu;Matsuzaki Yasunori;Hirai Hirokazu, Mar. 2023, Molecular therapy. Methods & clinical development, 29

  DOI
• Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice., Yaguchi Kasane;Hagihara Mitsue;Konno Ayumu;Hirai Hirokazu;Yukinaga Hiroko;Miyamichi Kazunari, May 2023, PloS one, 18, 5

  DOI
• Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans., Murase Shuhei;Sakitani Naoyoshi;Maekawa Takahiro;Yoshino Daisuke;Takano Kouji;Konno Ayumu;Hirai Hirokazu;Saito Taku;Tanaka Sakae;Shinohara Keisuke;Kishi Takuya;Yoshikawa Yuki;Sakai Takamasa;Ayaori Makoto;Inanami Hirohiko;Tomiyasu Koji;Takashima Atsushi;Ogata Toru;Tsuchimochi Hirotsugu;Sato Shinya;Saito Shigeyoshi;Yoshino Kohzoh;Matsuura Yuiko;Funamoto Kenichi;Ochi Hiroki;Shinohara Masahiro;Nagao Motoshi;Sawada Yasuhiro, Jul. 2023, Nature biomedical engineering

  DOI
• Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes., Ozawa Katsuya;Nagao Masaki;Konno Ayumu;Iwai Youichi;Vittani Marta;Kusk Peter;Mishima Tsuneko;Hirai Hirokazu;Nedergaard Maiken;Hirase Hajime, Sep. 2023, International journal of molecular sciences, 24, 17

  DOI
• State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice., Nagashima Takashi;Mikami Kaori;Tohyama Suguru;Konno Ayumu;Hirai Hirokazu;Watabe Ayako M, Nov. 2023, Frontiers in neural circuits, 17

  DOI
• Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice., Morishima Mieko;Matsumura Sohta;Tohyama Suguru;Nagashima Takashi;Konno Ayumu;Hirai Hirokazu;Watabe Ayako M, Dec. 2023, Frontiers in cellular neuroscience, 17

  DOI
• Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization., Kawabata Hayato;Konno Ayumu;Matsuzaki Yasunori;Sato Yumika;Kawachi Mika;Aoki Ryo;Tsutsumi Saki;Togai Shota;Kobayashi Ryosuke;Horii Takuro;Hatada Izuho;Hirai Hirokazu, Jan. 2024, Molecular therapy. Methods & clinical development, 32, 1

  DOI
• Anxiety control by astrocytes in the lateral habenula., Tan Wanqin;Ikoma Yoko;Takahashi Yusuke;Konno Ayumu;Hirai Hirokazu;Hirase Hajime;Matsui Ko, Feb. 2024, Neuroscience research

  DOI
• Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells., Watanave Masashi;Kawachi Mika;Konno Ayumu;Aoki Ryo;Fukai Yuuki;Matsuzaki Yasunori;Kaneko Ryosuke;Hirai Hirokazu, Feb. 2024, Frontiers in cellular neuroscience, 18

  DOI
• 抑制性ニューロン特異的AAVベクターの開発とその応用, ;;;, May 2024, 74, 2, 189
• Enhancement of Protein Thermostability by Accelerated Evolution, OGAWA Tomohisa;KON-NO Ayumu;MURAMOTO Koji;SHIRAI Tsuyoshi, 2006, Seibutsu Butsuri, 46, 4, 201, 208

  DOI
• 第65回北関東医学会総会, ;;;;;;;, Aug. 2018, 68, 3, 211, 211
• Motor dysfunction is triggered by miRNA-mediated knockdown of LAMP2A in mouse cerebellar neurons, Sato Masahiro;Ohta Tomoko;Seki Takahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Katsuki Hiroshi, 2020, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93, 0, 2-P-187

  DOI
• D-Cysteine regulates chaperone-mediated autophagy and microautophagy through the generation of hydrogen sulfide., Erika Ueda;Seki Takahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Katsuki Hiroshi, 2021, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94, 0, 1-P1-33

  DOI
• Motor dysfunction and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons., Seki Takahiro;Sato Masahiro;Ohta Tomoko;Morikawa Yuri;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Katsuki Hiroshi, 2021, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94, 0, 2-O-B2-1

  DOI
• In vitro evolutionary thermostabilization of congerin II: a limited reproduction of natural protein evolution by artificial selection pressure., Shionyu-Mitsuyama Clara;Ito Yoshimaro;Konno Ayumu;Miwa Yukiko;Ogawa Tomohisa;Muramoto Koji;Shirai Tsuyoshi, Jan. 2005, Journal of molecular biology, 347, 2

  DOI
• Reconstruction of a probable ancestral form of conger eel galectins revealed their rapid adaptive evolution process for specific carbohydrate recognition., Konno Ayumu;Ogawa Tomohisa;Shirai Tsuyoshi;Muramoto Koji, Sep. 2007, Molecular biology and evolution, 24, 11

  DOI
• UV irradiation promotes the accumulation of triglyceride in Lipomyces lipofer., Konno Ayumu;Suzuki Yoshihisa;Ogawa Tomohisa;Taniuchi Tetsuo, Nov. 2009, Bioscience, biotechnology, and biochemistry, 73, 11

  DOI
• Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants., Konno Ayumu;Yonemaru Shintarou;Kitagawa Atsushi;Muramoto Koji;Shirai Tsuyoshi;Ogawa Tomohisa, Feb. 2010, BMC evolutionary biology, 10

  DOI
• Tracing protein evolution through ancestral structures of fish galectin., Konno Ayumu;Kitagawa Atsushi;Watanabe Mizuki;Ogawa Tomohisa;Shirai Tsuyoshi, Structure (London, England : 1993), 19, 5

  DOI
• Evaluation of a Sindbis virus vector displaying an immunoglobulin-binding domain: antibody-dependent infection of neurons in living mice., Konno Ayumu;Honjo Tatsuya;Uchida Atsushi;Ishizuka Toru;Yawo Hiromu, Sep. 2011, Neuroscience research, 71, 4

  DOI
• Virally induced CRISPR/Cas9-based knock-in of fluorescent albumin allows long-term visualization of cerebral circulation in infant and adult mice., Vittani Marta;Knak Philip Aleksander Gade;Fukuda Masahiro;Nagao Masaki;Wang Xiaowen;Kjaerby Celia;Konno Ayumu;Hirai Hirokazu;Nedergaard Maiken;Hirase Hajime, Jul. 2023, bioRxiv : the preprint server for biology

  DOI
• Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice., Kinoshita Keita;Motomura Kensuke;Ushida Keisuke;Hirata Yuma;Konno Ayumu;Hirai Hirokazu;Kotani Shunsuke;Hitora-Imamura Natsuko;Kurauchi Yuki;Seki Takahiro;Katsuki Hiroshi, May 2024, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 21, 4

  DOI
• Production of Spinocerebellar Ataxia Type 3 Model Mice by Intravenous Injection of AAV-PHP.B Vectors., Konno Ayumu;Shinohara Yoichiro;Hirai Hirokazu, Jun. 2024, International journal of molecular sciences, 25, 13

  DOI
• Optimal different adeno-associated virus capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex., Matsuzaki Yasunori;Fukai Yuuki;Konno Ayumu;Hirai Hirokazu, Sep. 2024, Molecular therapy. Methods & clinical development, 32, 4

  DOI
• Critical factors for flow cytometry analysis of the brain., Sadakata Mizuki;Konno Ayumu;Takase Akinori;Kasamatsu Tetsuhiro;Iijima Takatoshi;Hirai Hirokazu;Sadakata Tetsushi, Mar. 2025, The FEBS journal

  DOI
• A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments., Pan Miao;Liu Pin-Wu;Ozawa Yukihiro;Arima-Yoshida Fumiko;Dong Geyao;Sawahata Masahito;Mori Daisuke;Nagase Masashi;Fujii Hajime;Ueda Shuhei;Yabuuchi Yurie;Liu Xinzi;Narita Hajime;Konno Ayumu;Hirai Hirokazu;Ozaki Norio;Yamada Kiyofumi;Kidokoro Hiroyuki;Bito Haruhiko;Mizoguchi Hiroyuki;M Watabe Ayako;Horigane Shin-Ichiro;Takemoto-Kimura Sayaka, Mar. 2025, Translational psychiatry, 15, 1

  DOI

MISC

• 進化工学による魚類ガレクチンの耐熱化とその構造要素の解析, 今野歩; 伊藤由麿; 小川智久; 塩生(光山)くらら; 白井剛; 村本光二, 05 Mar. 2004, 日本農芸化学会大会講演要旨集, 2004, 100
• 加速進化型ガレクチンの糖結合特異性に対する網羅的変異解析, 今野歩; 小川智久; 村本光二, 05 Mar. 2005, 日本農芸化学会大会講演要旨集, 2005, 24
• 祖先型マアナゴ ガレクチンCongerinの復元, 今野歩; 小川智久; 白井剛; 村本光二, 05 Mar. 2006, 日本農芸化学会大会講演要旨集, 2006, 28
• 魚類ガレクチンの変異体作成とその応用性, 今野歩; 小川智久; 村本光二; 神谷久男, 30 Mar. 2006, 日本水産学会大会講演要旨集, 2006, 265
• ガレクチンの加速進化による糖認識能の多様化:祖先型ガレクチンの復元による解析, 小川智久; 今野歩; 白井剛; 村本光二, 28 Jul. 2006, 日本糖質学会年会要旨集, 26th, 75
• 加速進化型ガレクチン,コンジェリンのゲノム遺伝子構造の解析, 山岸興; 小川智久; 今野歩; 中村修; 村本光二, 2007, 生化学, 4P-1251
• ガレクチンの多様な糖鎖結合能に関わるループ構造の重要性, 安川泰史; 今野歩; 小川智久; 村本光二, 2007, 日本農芸化学会東北支部大会プログラム・講演要旨集, 142nd, 22
• 分子進化トレース法による魚類ガレクチンの糖鎖認識能に関わる構造要素の解析, 今野歩; 小川智久; 白井剛; 村本光二, 10 Jul. 2007, 日本糖質学会年会要旨集, 27th, 109
• 祖先型変異体によるアナゴガレクチンの分子進化に関わる構造要素の解析, 今野歩; 小川智久; 白井剛; 村本光二, 05 Mar. 2007, 日本農芸化学会大会講演要旨集, 2007, 158
• 祖先型タンパク質による機能解析:加速進化型アナゴガレクチンを例として, 今野歩; 小川智久; 白井剛; 村本光二, 07 May 2007, 日本蛋白質科学会年会プログラム・要旨集, 7th, 64
• 魚類ガレクチンの糖結合特異性に関わる構造要素の解明, 安川泰史; 今野歩; 小川智久; 村本光二, 07 May 2007, 日本蛋白質科学会年会プログラム・要旨集, 7th, 64
• コンジェリン進化過程の構造生物学的研究, 北川篤; 今野歩; 小川智久; 村本光二; 白井剛, 23 May 2008, 日本蛋白質科学会年会プログラム・要旨集, 8th, 105
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, 定方 哲史; 細井 延武; 柴崎 貢志; 今野 歩; 平井 宏和; 石崎 泰樹; 古市 貞一, Sep. 2019, 日本生化学会大会プログラム・講演要旨集, 92回, [1T14a, 01]
• モデルマウスを用いた本態性振戦発症機序の解明, 細井 延武; 柴崎 貢志; 今野 歩; 村松 慎一; 石崎 泰樹; 平井 宏和; 古市 貞一; 定方 哲史, Aug. 2018, 68, 3, 211, 211
• モデルマウスを用いた本態性振戦発症機序の解明, 細井延武; 柴崎貢志; 今野歩; 村松慎一; 石崎泰樹; 平井宏和; 古市貞一; 定方哲史, Aug. 2018, 北関東医学会総会プログラム・抄録, 65th, 3, 31, 211
• 加速進化によるタンパク質の耐熱化 : 進化工学による耐熱化機構の解明から, 小川智久; 今野歩; 村本光二; 白井剛, 25 Jul. 2006, 46, 4, 201, 208

  DOI
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry Chan; Hirokazu Hirai, May 2015, MOLECULAR THERAPY, 23, S237, S237, Summary international conference
• The gene transfer through neuron-type specific membrane proteins using Sindbis virus vector displaying specific antibody, Ayumu Konno; Tatsuya Honjo; Toru Ishizuka; Hiromu Yawo, 2010, NEUROSCIENCE RESEARCH, 68, E220, E220, Summary international conference

  DOI
• Targeted gene transfer by sindbis virus vector displaying the cell-specific antibody, Ayumu Konno; Tatsuya Honjo; Toru Ishizuka; Hiromu Yawo, 2010, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S206, S206, Summary international conference

Books etc

• Ancestral protein reconstruction as a new field in protein engineering In Ribosomal Proteins and Protein Engineering: Design, Selection and Applications (Ortendhal, V. & Salchow, H., eds.), Joint work, Konno, A; Ogawa, T; Shirai, T, Nova Science Publishers, NY., 2010
• 決定版ウイルスベクターによる遺伝子導入実験ガイド : 培養細胞から個体まで、研究を飛躍させる実践テクニックのすべて, Contributor, Nov. 2020, 281, 11p, ISBN: 9784758122474
• クローズアップ実験法「ウイルスベクターの静脈投与によるマウス全脳域への遺伝子導入」, Joint work, Mar. 2019, 6, p496-636, 10p, ISBN: 9784758125178

Presentations

• Combination of AAV-PHP.B with a cell type-specific promoter can express a transgene in a cell type-specific manner throughout the brain., Ayumu Konno; Yoichiro Shinohara; Keisuke Nitta; Chiaki Hoshino; Hirokazu Hirai, 9th International Symposium of the Society for Research on the Cerebellum and Ataxias, 16 May 2018, English, International conference
• In vivo evaluation of shortened version of neuron-specific enolase promoter, Ayumu Konno; Yoichiro Shinohara; Toshinori Ohtani; Hirokazu Hirai, 7th annual meeting of International Society of Radiation Neurobiology, 09 Feb. 2017, International conference
• Generation of a marmoset model of spinocerebellar ataxia type 3 via AAV9 vector-mediated gene transfer, Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, Neuroscience2016, 14 Nov. 2016, English, International conference
• AAV9 vector-mediated production of animal models of spinocerebellar ataxia, Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, International Society of Radiation Neurobiology 6th Conference, 12 Feb. 2016, International conference
• Producing animal models of spinocerebellar ataxia type 3 via a viral vector-mediated gene delivery, Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, International Society of Radiation Neurobiology 5th Conference, 21 Feb. 2015, International conference
• Production of animal models of spinocerebellar ataxia type 3 by a viral vector-mediated gene delivery, Ayumu Konno; Yasunori Matsuzaki; Naoya Ohta; Hirokazu Hirai, GUMI&AMDE2014, 05 Dec. 2014, International conference
• Perturbation of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the rescue by intravascular administration of AAV9, A. KONNO; A. N. SHUVAEV; S. YANAGI; H. HIRAI, Neuroscience2013, 10 Nov. 2013, English, International conference
• Disruption of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the partial restoration via intravenous administration of AAV9, A. KONNO; A. N. SHUVAEV; S. YANAGI; H. HIRAI, 23rd Neuropharmacology Conference, 07 Nov. 2013, English, International conference
• Antibody-directed gene delivery with Sindbis viral vectors displaying the IgG-binding domain of protein A, Ayumu KonnoAyumu Konno; Tatsuya Honjo; Toru Ishizuka; Hiromu Yawo, International Symposium on Multidisciplinary Neuroscience, 21 Jan. 2011, English, International conference
• Cell type-specific transgene expression throughout the brain by intravenous injection of AAV-PHP.B, 今野 歩; 篠原 洋一郎; 新田 啓介; 星野 千秋; 平井 宏和, 第41回日本神経科学大会, 28 Jul. 2018, Domestic conference
• アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, 今野 歩; 渡邊 将; 星野 千秋; 篠原 洋一郎; 松﨑 泰教; 平井 宏和, 2017年度生命科学系学会合同年次大会（ConBio2017）, 08 Dec. 2017, Japanese, Domestic conference
• PHP.B-mediated cell type-specific gene expression in mouse CNS in vivo, Ayumu Konno; Yoichiro Sh; Keisuke Nitta; Hirokazu Hirai, 第9回光操作研究会, 21 Oct. 2017, Domestic conference
• In vivo evaluation of the shortened-WPRE in the cerebellum, Ayumu Konno; Kazuma Hachisu; Hirokazu Hirai, 第40回日本神経科学大会, 22 Jul. 2017, Domestic conference
• Generation of animal models of spinocerebellar ataxia via AAV9 vector-mediated gene transfer, Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, 第22回日本遺伝子細胞治療学会学術集会, 29 Jul. 2016, Domestic conference
• Optimization of the neuron-specific enolase promoter for AAV vectors, Ayumu Konno; Yoichiro Shinohara; Toshinori Ohtani; Hirokazu Hirai, 第39回日本神経科学大会, 21 Jul. 2016, Domestic conference
• Generation of animal models of spinocerebellar ataxia by AAV9-mediated gene delivery, Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, 第93回日本生理学会大会, 23 Mar. 2016, Domestic conference
• A marmoset model of spinocerebellar ataxia type 3 generated using AAV vectors, Ayumu Konno; Yasunori Matsuzaki; Yoichiro Shinohara; Hirokazu Hirai, 第38回日本神経科学大会, 28 Jul. 2015, Domestic conference
• アデノ随伴ウイルスによる小脳全域への遺伝子導入を介した脊髄小脳変性症3型モデル動物の作出, 今野歩; 松﨑泰教; 平井宏和, 2014年度包括型脳科学研究推進支援ネットワーク冬のワークショップ, 12 Dec. 2014, Domestic conference
• AAV9 vector-mediated production of animal models of spinocerebellar ataxia type 3, Ayumu Konno; Hirokazu Hirai, 第37回日本神経科学大会, 13 Sep. 2014, Domestic conference
• DISRUPTION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALING AND RESCUE THROUGH INTRAVASCULAR ADMINISTRATION OF AAV9 IN A MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE 3, Ayumu Konno; Anton N. Shuvaev; Noriko Miyake; Koichi Miyake; Shigeru Yanagi; Takashi Shimada; Hirokazu Hirai, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, Domestic conference
• Deficient metabotropic glutamate receptor signaling and rescue through intravascular administration of AAV9 in a mouse model of spinocerebellar ataxia type 3, 今野 歩; Anton N Shuvaev; 三宅 紀子; 三宅 弘一; 柳 茂; 島田 隆; 平井 宏和, Neuro2013（第36回日本神経科学大会）, 20 Jun. 2013, Domestic conference
• Gene therapy for spinocerebellar ataxia type-3 using trans-blood-brain barrier gene delivery by AAV9, 今野 歩; Anton N Shuvaev; 三宅 紀子; 三宅 弘一; 柳 茂; 島田 隆; 平井 宏和, 第35回日本神経科学大会, 19 Sep. 2012, Domestic conference
• 抗体提示型シンドビスウイルスベクターによる抗体依存的な遺伝子導入技術の評価, 今野 歩; 本城 達也; 内田 敦; 石塚 徹; 八尾 寛, 2011年度包括型脳科学研究推進支援ネットワーク夏のワークショップ, 23 Aug. 2011, Domestic conference
• The gene transfer through neuron-type specific membrane proteins using Sindbis virus vector displaying specific antibody, 今野 歩; 本城 達也; 石塚 徹; 八尾 寛, Neuro2010（第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会）, 02 Sep. 2010, Domestic conference
• Comprehensive mutation analysis of carbohydrate-binding specificity of conger eel galectins, 今野 歩; 小川 智久; 村本 光二, 第76回日本生化学会大会, Oct. 2003, Japanese, Domestic conference
• 進化工学による魚類ガレクチンの耐熱化とその構造要素の解析, 今野歩; 小川智久; 伊藤由麿; 塩生-光山くらら; 白井剛; 村本光二, 2004年度農芸化学会大会, Mar. 2004, Japanese, Domestic conference
• Comprehensive mutation analyses of conger eel galectins, Congerins I and II, reveal their unique carbohydrate-binding specificities, Ayumu Konno; Tomohisa Ogawa; Koji Muramoto, Interlec21: 21st International Lectin Meeting, May 2004, English, International conference
• 進化工学およびX線構造解析による魚類ガレクチンの耐熱化メカニズムの解明, 今野歩; 伊藤由麿; 小川智久; 塩生-光山くらら; 白井剛; 村本光二, 平成１６年度生物物理学会東北支部総会, Jun. 2004, Japanese, Domestic conference
• Comprehensive mutation analyses of conger eel galectins, Congerins I and II, reveal their unique carbohydrate-binding specificities, 今野 歩; 小川 智久; 村本 光二, 第５１回FCCA セミナー・第１１回グライコサイエンス若手の会, Aug. 2004, Japanese, Domestic conference
• Structural elements involved in the highly thermal stability of fish galectin, 今野歩; 伊藤由麿; 小川智久; 塩生-光山くらら; 白井剛; 村本光二, 第77回日本生化学会大会, Oct. 2004, Japanese, Domestic conference
• 加速進化型ガレクチンの糖結合特異性に対する網羅的変異解析, 今野 歩; 小川 智久; 村本光二, 日本農芸化学会2005年度大会, Mar. 2005, Japanese, Domestic conference
• Application of Congerin mutants with unique sugar binding profiles as tool for analyzing the carbohydrate structures and activities, 今野 歩; 小川 智久; 村本 光二, 第78回日本生化学会大会, Oct. 2005, Japanese, Domestic conference
• 祖先型マアナゴ ガレクチンCongerinの復元, 今野歩; 小川智久; 白井剛; 村本光二, 2006年度日本農芸化学会大会, Mar. 2006, Japanese, Domestic conference
• Reconstruction of ancestral Conger eel galectins have revealed their accelerated evolution process, Tomohisa Ogawa; Ayumu Konno; Koji Muramoto; Tsuyoshi Shirai, 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Jun. 2006, English, International conference
• 祖先型変異体によるアナゴガレクチンの分子進化に関わる構造要素の解析, 今野 歩; 小川 智久; 白井 剛; 村本 光二, 2007年度日本農芸化学会大会, Mar. 2007, Japanese, Domestic conference
• 祖先型タンパク質による機能解析：加速進化型アナゴ ガレクチンを例として, 今野 歩; 小川 智久; 白井 剛; 村本 光二, 第７回日本蛋白質科学会年会, May 2007, Japanese, Domestic conference
• 分子進化トレース法による魚類ガレクチンの糖鎖認識能に関わる構造要素の解析, 今野 歩; 小川 智久; 白井 剛; 村本 光二, 第27回日本糖質学会年会, Aug. 2007, Japanese, Domestic conference
• 魚類ガレクチンはどのように進化してきたのか？：祖先型タンパク質の復元解析から, 今野 歩; 小川 智久; 白井 剛; 村本 光二, 第1回東北糖鎖研究会, Dec. 2007, Japanese, Domestic conference
• Targeted gene transfer by sindbis virus vector displaying the cell-specific antibody, 今野 歩; 本城 達也; 石塚 徹; 八尾 寛, 第87回日本生理学会大会, May 2010, Japanese, Domestic conference
• Antibody-Dependent Gene Transfer Using Sindbis Virus Vectors Displaying IgG-binding Domains of Protein A, Ayumu Konno; Lei Wen; Tatsuya Honjo; Toru Ishizuka; Hiromu Yawo, Tohoku University – Taiwan Neuroscience Workshop for Young Scientists, Jan. 2010, English, International conference

Awards

• Feb. 2017
• Jul. 2016
• Jul. 2013
• 学生優秀発表賞, 今野 歩, 生物物理学会 東北支部, Jun. 2004
• 生命科学研究科長賞, 今野 歩, 東北大学 生命科学研究科, Mar. 2008

Research Projects

• Aug. 2017, Mar. 2018, Principal investigator, Competitive research funding
• Apr. 2016, Mar. 2020, Competitive research funding
• Apr. 2016, Mar. 2017, Principal investigator, Competitive research funding
• Apr. 2015, Mar. 2016, Principal investigator, Competitive research funding
• Apr. 2015, Mar. 2018, Principal investigator, Competitive research funding
• Aug. 2014, Mar. 2015, Principal investigator, Competitive research funding
• Jul. 2013, Mar. 2014, Principal investigator, Competitive research funding
• Apr. 2012, Mar. 2015, Principal investigator, Competitive research funding, 24700394

  対象リソースIRI
• Aug. 2012, Mar. 2013, Principal investigator, Competitive research funding
• Jul. 2013, Mar. 2014, Principal investigator, Competitive research funding
• 01 Apr. 2020, 31 Mar. 2024, 20K05933
• 01 Apr. 2019, 31 Mar. 2022, 19K06899
• Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing, Hirai Hirokazu; HOSOI Nobutake; KONNO Ayumu; MATSUZAKI Yasunori, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 01 Apr. 2016, 31 Mar. 2018, In this research, we aimed to establish a technique that allows elimination of a disease-causing gene from specific cell populations in the brain, using adeno-associated virus (AAV) vectors in combination with CRISPR/Cas9 system. Initially, we characterized neuron-specific, astrocyte-specific and cerebellar Purkinje cell-specific promoters available for AAV vector-mediated transgene expression. The results were published in 3 papers. Then, using the AAV vectors, we examined whether a gene responsible for developmental defects of the brain could be knocked out from Purkinje cells by CRISPR/Cas9 system. The results showed successful removal of the gene from around two thirds of Purkinje cells., 16K15477

  対象リソースIRI