Researcher Profile and Settings

Researcher

• Name

  NISHIMURA Takashi

Affiliation

• Institute for Molecular and Cellular Regulation, Professor

Profile and Settings

• Name

  Nishimura, Takashi

ホームページ

• URI

  https://sites.google.com/view/nishimura-lab/, Lab HP

Affiliation

• RIKEN Center for Biosystems Dynamics Research, Laboratory for Morphogenetic Signaling, Senior Researcher

Education

• Apr. 2001, Mar. 2004, Nagoya University, Graduate School of Medicine
• Apr. 1999, Mar. 2001, Nara Institute of Science and Technology, Graduate School of Biological Science
• Apr. 1995, Mar. 1999, Hokkaido University, School of Fisheries Sciences

Degree

• Ph.D.

Research Experience

• Mar. 2021, 9999, Gunma University, Institute for Molecular and Cellular Regulation, Laboratory of Metabolic Regulation and Genetics, Professor, Prof lv
• Jul. 2019, Feb. 2021, RIKEN Center for Biosystems Dynamics Research, Laboratory for Morphogenetic Signaling, Senior Researcher
• Apr. 2018, Jun. 2019, RIKEN Center for Biosystems Dynamics Research, Laboratory for Growth Control Signaling, Team Leader
• Nov. 2014, Apr. 2018, RIKEN Center for Developmental Biology, Laboratory for Growth Control Signaling, Team Leader
• Jul. 2009, Nov. 2014, RIKEN Center for Developmental Biology, Laboratory for Growth Control Signaling, Team Leader
• Apr. 2009, Jun. 2009, RIKEN Center for Developmental Biology, Visiting Researcher
• Apr. 2006, Mar. 2009, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, HFSP long-term fellowship
• Apr. 2004, Mar. 2006, Nagoya University Graduate School of Medicine, JSPS Research Fellow (PD)

Research Activities

Research Areas

• Life sciences, Animals: biochemistry, physiology, behavioral science
• Life sciences, Genetics
• Life sciences, Developmental biology

Research Interests

• Environmental adaptation
• Insulin-like peptide
• Steroid horomone
• Neural stem cell
• Developmental timing
• Metabolic homeostasis
• Body Growth
• Drosophila melanogaster

Published Papers

• A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster., Yoshinari Y#, Nishimura T#, Yoshii T, Kondo S, Tanimoto H, Kobayashi T, Matsuyama M, Niwa R#, 30 Dec. 2024, Nature Communications, 15, 1, 10819

  DOI
• Arrayed CRISPRi library to suppress genes required for Schizosaccharomyces pombe viability, Ishikawa K, Soejima S, Nishimura T, Saitoh S, 08 Oct. 2024, Journal of Cell Biology, 224, 1, e202404085, Scientific journal

  DOI
• Sex-dependent regulation of vertebrate somatic growth and aging by germ cells, Abe K, Ino H, Niwa T, Semmy D, Takaochi A, Nishimura T, Mogi C, Uenaka M, Ishii M, Tanaka K, Ohkawa Y, Ishitani T#, 14 Jun. 2024, Science Advances, 10, 24, eadi1621, Scientific journal

  DOI
• Nacα protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila, Yamada T, Yoshinari Y, Tobo M, Habara O, Nishimura T., 01 Sep. 2023, Nat Commun, 14, 1, 1, 19, Scientific journal

  DOI
• Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila., Hoshino R, Sano H, Yoshinari Y, Nishimura T, Niwa R, Feb. 2023, Science Advances, 9, 8, 1, 16

  DOI
• Isolation of a novel missense mutation in insulin receptor as a spontaneous revertant of ImpL2 mutants in Drosophila., Banzai K, and Nishimura T, Jan. 2023, Development, 150, 1, 1, 14

  DOI
• The polyol pathway is an evolutionarily conserved system for sensing glucose uptake, Hiroko Sano, Akira Nakamura, Mariko Yamane, Hitoshi Niwa, Takashi Nishimura, Kimi Araki, Kazumasa Takemoto, Kei-Ichiro Ishiguro, Hiroki Aoki, Yuzuru Kato, Masayasu Kojima, 2022, PLoS Biolology, 20, 6, 1, 25, Scientific journal

  DOI
• Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes, Hanna M Ciesielski, Hiroshi Nishida, Tomomi Takano, Aya Fukuhara, Tetsuhisa Otani, Yuko Ikegawa, Morihiro Okada, Takashi Nishimura, Mikio Furuse, Sa Kan Yoo, 2022, PLoS Biology, 20, 4, 1, 21

  DOI
• Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti, Inaba K, Ebihara K, Senda M, Yoshino R, Sakuma C, Koiwai K, Takaya D, Watanabe C, Watanabe A, Kawashima Y, Fukuzawa K, Imamura R, Kojima H, Okabe T, Uemura N, Kasai S, Kanuka H, Nishimura T, Watanabe, 17 Feb. 2022, BMC Biology, 20, 1, 43

  DOI
• Sima, a Drosophila homolog of HIF-1α, in fat body tissue inhibits larval body growth by inducing Tribbles gene expression, Noguchi K, Yokozeki K, Tanaka Y, Suzuki Y, Nakajima K, Nishimura T, Goda N., 27 Feb. 2022, Genes Cells, 27, 2, 145, 151

  DOI
• white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila., Ayaka Sasaki; Takashi Nishimura; Tomomi Takano; Saki Naito; Sa Kan Yoo, Apr. 2021, Nature Metabolism, 3, 4, 546, 557, Scientific journal

  DOI
• A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila, Takayuki Yamada; Ken-ichi Hironaka; Okiko Habara; Yoshihiro Morishita; Takashi Nishimura, Oct. 2020, Nature Metabolism, 2, 10, 1096, 1112, Scientific journal

  DOI
• Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila, Takashi Nishimura, Sep. 2020, Current Biology, 30, 18, 3624, 3632.e5, Scientific journal

  DOI
• The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster., Eisuke Imura; Yuko Shimada-Niwa; Takashi Nishimura; Sebastian Hückesfeld; Philipp Schlegel; Yuya Ohhara; Shu Kondo; Hiromu Tanimoto; Albert Cardona; Michael J Pankratz; Ryusuke Niwa, 08 Jun. 2020, Current biology : CB, 30, 11, 2156, 2165, Scientific journal

  DOI
• Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis, Ryota Matsushita; Takashi Nishimura, Apr. 2020, Communications Biology, 3, 1, 170, Scientific journal

  DOI
• Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly, Jordan T. Silver; Frederik Wirtz-Peitz; Sérgio Simões; Milena Pellikka; Dong Yan; Richard Binari; Takashi Nishimura; Yan Li; Tony J.C. Harris; Norbert Perrimon; Ulrich Tepass, 07 Oct. 2019, Journal of Cell Biology, 218, 10, 3397, 3414, Scientific journal

  DOI
• Optimal Scaling of Critical Size for Metamorphosis in the Genus Drosophila, Ken-ichi Hironaka; Koichi Fujimoto; Takashi Nishimura, Oct. 2019, iScience, 20, 348, 358, Scientific journal

  DOI
• The role of glycogen in development and adult fitness in Drosophila, Takayuki Yamada; Okiko Habara; Yuka Yoshii; Ryota Matsushita; Hitomi Kubo; Yosui Nojima; Takashi Nishimura, 15 Apr. 2019, Development, 146, 8, dev176149, dev176149, Scientific journal

  DOI
• Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in drosophila, Takayuki Yamada; Okiko Habara; Hitomi Kubo; Takashi Nishimura, 01 Mar. 2018, Development, 145, 6, dev158865, Scientific journal

  DOI
• Assembly of insect hormone enthusiasts at Nasu Highland, Japan: Report of the 3rd International Insect Hormone (21st Ecdysone) Workshop, Ryusuke Niwa; Takashi Nishimura, 01 Jan. 2018, Genes to Cells, 23, 1, 16, 21, International conference proceedings

  DOI
• Adaptation to dietary conditions by trehalose metabolism in Drosophila, Tetsuo Yasugi; Takayuki Yamada; Takashi Nishimura, 01 Dec. 2017, Scientific Reports, 7, 1, Scientific journal

  DOI
• Molecular characterization of Tps1 and Treh genes in Drosophila and their role in body water homeostasis, Miki Yoshida; Hiroko Matsuda; Hitomi Kubo; Takashi Nishimura, 29 Jul. 2016, Scientific Reports, 6, 1, Scientific journal

  DOI
• Temporal regulation of the generation of neuronal diversity in Drosophila, Tetsuo Yasugi; Takashi Nishimura, 01 Jan. 2016, Development Growth and Differentiation, 58, 1, 73, 87, Scientific journal

  DOI
• Signaling from Glia and Cholinergic Neurons Controls Nutrient-Dependent Production of an Insulin-like Peptide for Drosophila Body Growth, Naoki Okamoto; Takashi Nishimura, 09 Nov. 2015, Developmental Cell, 35, 3, 295, 310, Scientific journal

  DOI
• Flies without trehalose, Hiroko Matsuda; Takayuki Yamada; Miki Yoshida; Takashi Nishimura, 09 Sep. 2015, Journal of Biological Chemistry, 290, 2, 1244, 1255, Scientific journal

  DOI
• A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in drosophila, Naoki Okamoto; Rinna Nakamori; Tomoka Murai; Yuki Yamauchi; Aya Masuda; Takashi Nishimura, 01 Jan. 2013, Genes and Development, 27, 1, 87, 97, Scientific journal

  DOI
• Conserved role for the Dachshund protein with Drosophila Pax6 homolog eyeless in insulin expression, Naoki Okamoto; Yuka Nishimori; Takashi Nishimura, 14 Feb. 2012, Proceedings of the National Academy of Sciences of the United States of America, 109, 7, 2406, 2411, Scientific journal

  DOI
• Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis, Norimichi Itoh; Masanori Nakayama; Takashi Nishimura; Shin Fujisue; Tomoki Nishioka; Takashi Watanabe; Kozo Kaibuchi, May 2010, Cytoskeleton, 67, 5, 297, 308, Scientific journal

  DOI
• Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization, Frederik Wirtz-Peitz; Takashi Nishimura; Juergen A. Knoblich, Oct. 2008, Cell, 135, 1, 161, 173, Scientific journal

  DOI
• Rho-Kinase Phosphorylates PAR-3 and Disrupts PAR Complex Formation, Masanori Nakayama; Takaaki M. Goto; Masayuki Sugimoto; Takashi Nishimura; Takafumi Shinagawa; Sigeo Ohno; Mutsuki Amano; Kozo Kaibuchi, 12 Feb. 2008, Developmental Cell, 14, 2, 205, 215, Scientific journal

  DOI
• Numb Controls Integrin Endocytosis for Directional Cell Migration with aPKC and PAR-3, Takashi Nishimura; Kozo Kaibuchi, 03 Jul. 2007, Developmental Cell, 13, 1, 15, 28, Scientific journal

  DOI
• Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation, Mikito Takefuji; Kazutaka Mori; Yasuhiro Morita; Nariko Arimura; Takashi Nishimura; Masanori Nakayama; Mikio Hoshino; Akihiro Iwamatsu; Toyoaki Murohara; Kozo Kaibuchi; Mutsuki Amano, 13 Apr. 2007, Biochemical and Biophysical Research Communications, 355, 3, 788, 794, Scientific journal

  DOI
• Role of Numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2, Takashi Nishimura; Tomoya Yamaguchi; Akinori Tokunaga; Akitoshi Hara; Tomonari Hamaguchi; Katsuhiro Kato; Akihiro Iwamatsu; Hideyuki Okano; Kozo Kaibuchi, Mar. 2006, Molecular Biology of the Cell, 17, 3, 1273, 1285, Scientific journal

  DOI
• PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1, Takashi Nishimura; Tomoya Yamaguchi; Katsuhiro Kato; Masato Yoshizawa; Yo-Ichi Nabeshima; Shigeo Ohno; Mikio Hoshino; Kozo Kaibuchi, Mar. 2005, Nature Cell Biology, 7, 3, 270, 277, Scientific journal

  DOI
• Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity, Takashi Nishimura; Katsuhiro Kato; Tomoya Yamaguchi; Yuko Fukata; Shigeo Ohno; Kozo Kaibuchi, Apr. 2004, Nature Cell Biology, 6, 4, 328, 334, Scientific journal

  DOI
• 【脳・神経研究2004 神経発生・可塑性と高次脳機能のメカニズム,そして脳・神経疾患の分子機構の解明へ】神経系の発生・分化と回路形成 神経細胞の極性形成機構, 西村 隆史; 山口 知也; 加藤 勝洋; 貝淵 弘三, Nov. 2003, 21, 17, 2324, 2329
• 神経細胞極性制御分子CRMP-2はNumbを介したエンドサイトーシスに関与する, 西村 隆史; 加藤 勝洋; 山口 知也; 深田 優子; 貝淵 弘三, Oct. 2003, 22, 11, 1210, 1211
• CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth, Takashi Nishimura; Yuko Fukata; Katsuhiro Kato; Tomoya Yamaguchi; Yoshiharu Matsuura; Hiroyuki Kamiguchi; Kozo Kaibuchi, 01 Sep. 2003, Nature Cell Biology, 5, 9, 819, 826, Scientific journal

  DOI
• 細胞極性形成分子PAR-3の神経細胞における機能及び局在化機構の解析, 加藤 勝洋; 西村 隆史; 深田 優子; 大野 茂男; 貝淵 弘三, May 2003, 56回, 48, 48
• CRMP-2 binds to tubulin heterodimers to promote microtubule assembly, Yuko Fukata; Tomohiko J. Itoh; Toshihide Kimura; Celine Ménager; Takashi Nishimura; Takashi Shiromizu; Hiroyasu Watanabe; Naoyuki Inagaki; Akihiro Iwamatsu; Hirokazu Hotani; Kozo Kaibuchi, 2002, Nature Cell Biology, 4, 8, 583, 591, Scientific journal

  DOI
• 細胞極性形成分子ASIP結合タンパク質の同定, 加藤 勝洋; 西村 隆史; 則竹 淳; 中川 誠人; 深田 優子; 深田 正紀; 大野 茂男; 貝淵 弘三, May 2001, 54回, 93, 93
• CRMP-2 induces axons in cultured hippocampal neurons, Naoyuki Inagaki; Kazuyasu Chihara; Nariko Arimura; Céline Ménager; Yoji Kawano; Naruhiro Matsuo; Takashi Nishimura; Mutsuki Amano; Kozo Kaibuchi, 2001, Nature Neuroscience, 4, 8, 781, 782, Scientific journal

  DOI

Presentations

• Scaling of hormone levels with body size in the fruit fly Drosophila., Takashi Nishimura, The 10th IMCR Symposium on Endocrine and Metabolism, Oct. 2024
• 体サイズの変化に応じたホルモン量調節のスケーリング機構, 西村隆史, 第71回北関東医学総会, Sep. 2024
• 体サイズと分泌量の変化に応じたホルモン量の調節機構, 西村隆史, 第42回内分泌代謝サマーセミナー, Jul. 2024
• ショウジョウバエにおけるグルカゴン様ホルモンの分泌動態と生理機能の解析, 荒川 智成, 吉成 祐人, 西村 隆史, 第46回日本分子生物学会年会, 08 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023
• 蛋白恒常性の破綻により生じるアポートシス抵抗性細胞の細胞死, 山田 貴佑記, 西村 隆史, 第46回日本分子生物学会年会, 07 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023
• 進化的に保存された新規ホルモン様分子CG14075は飢餓応答を調節する, 吉成 祐人, 阿部 真生子, 星野 涼, 黒木 祥友, 水野 陽介, 井村 英輔, 西村 隆史, 丹羽 隆介, 第46回日本分子生物学会年会, 07 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023
• 分裂酵母の必須遺伝子ノックダウンライブラリによる遺伝子機能解析, 石川 健, 副島 朗子, ブラウン ウイリアム, 西村 隆史, 齋藤 成昭, 第46回日本分子生物学会年会, 07 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023
• グルコース感知による多細胞生命システムの自律性生成機構, 佐野 浩子, 中村 輝, 山根 万里子, 丹羽 仁史, 西村 隆史, 荒木 喜美, 竹本 一政, 石黒 啓一郎, 青木 浩樹, 加藤 譲, 第46回日本分子生物学会年会, 08 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023
• 発育過程における脳内インスリンシグナルの調節機構, 西村隆史, 新学術領域　第6回 領域班会議概要, 10 Dec. 2021, 09 Dec. 2021, 12 Dec. 2021
• Regulation of brain insulin signaling in Drosophila, Takashi Nishimiura, The 16th International Symposium of the Institute Network for Biomedical Sciences KEY FORUM 2021 International Symposium, 12 Nov. 2021, 11 Nov. 2021, 12 Nov. 2021, Kumamoto University
• 発育ステージの移行に伴うエネルギー代謝調節, 西村隆史, モデル生物代謝研究会, 05 Nov. 2021, 05 Nov. 2021, 05 Nov. 2021
• ショウジョウバエにおける貯蔵糖の代謝特性と生理的意義, 西村隆史, 第20回生体機能研究会, 15 Oct. 2021, 15 Oct. 2021, 16 Oct. 2021
• メタボローム技術講習会, 西村隆史, メタボローム技術講習会, 28 Sep. 2021, 28 Sep. 2021, 28 Sep. 2021
• Two glia-derived insulin/IGF-binding proteins antagonistically control neuroblast reactivation in Drosophila, Takashi NISHIMURA, JDRC14, 13 Sep. 2021, 13 Sep. 2021, 16 Sep. 2021
• 栄養状態に応じた脳内インスリンシグナルと神経産生の制御機構, 西村隆史, 群馬大学生体調節研究所　第7回内分泌・代謝シンポジウム, 09 Sep. 2021, 09 Sep. 2021, 10 Sep. 2021

Research Projects

• 01 Apr. 2021, 31 Mar. 2025, 21H02495
• 01 Apr. 2017, 31 Mar. 2020, 17H03658
• Toward understanding of regulatory mechanism of body growth and metabolism based on optimal control theory, Nishimura Takashi; Hironaka Ken-ichi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Institute of Physical and Chemical Research, 30 Jun. 2017, 31 Mar. 2019, In order to understand how species-specific final body size is determined, it is important to clarify how gene-environment interactions affect growth and metabolism at the level of organisms. The growth of many multicellular organisms are divided into two phases: the growth phase and the maturation phase. The progression to the maturation phase irreversibly determines the final body size. Using the fruit fly Drosophila as a model animal, we found that the threshold, which determins the progression to the maturation phase, adaptively optimizes energy allocation to support sexual maturation. Moreover, we reveaed that metabolic remodeling occurs after reaching the threshold through the action of endocrine hormones. Our study contributes to our understanding of the metabolic regulation as a life history strategy., 17K19433

  対象リソースIRI
• 01 Apr. 2017, 31 Mar. 2019, 17H05778
• Regulation of body growth and metabolism through nutritional signal, Nishimura Takashi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Institute of Physical and Chemical Research, 01 Apr. 2014, 31 Mar. 2017, Insulin/insulin-like growth factor (IGF) signaling plays an important role in the regulation of biological processes such as growth, metabolism, reproduction and longevity, and is known to be widely conserved across species. In mammals, major players of this pathway are insulin and IGF, which have distinct roles in metabolism and growth, respectively, whereas in the Drosophila fruit fly, there are eight insulin-like peptides (Dilps) that fulfill these roles. The function and regulation of these endocrine hormones must be capable of readily adapting to environmental changes, particularly to nutrient availability. Our work revealed a complex signaling relay and positive feedback mechanism at work to control the expression of dilp5 in the insulin-producing cells of the fly brain. These results provide a molecular framework that explains how the production of an endocrine hormone in a specific tissue is coordinated with environmental conditions., 26711007

  対象リソースIRI
• Analysis of amino acid signaling in mammals and Drosophila, NISHIMURA Takashi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), The Institute of Physical and Chemical Research, 01 Apr. 2011, 31 Mar. 2014, The multi-protein complex TORC1 is a key regulator of cell growth and size control in both Drosophila and mammals. To better understand amino acid signaling, we took a biochemical approach to identify the binding proteins of small GTPase RagA/C. We identified the glycolytic enzyme GAPDH and found that GAPDH likely regulates the TORC1 localization and activity through RagA/C. In addition, to understand how Drosophila recognizes nutrition to control body growth, we focused on the molecular mechanism underlying the nutrient-dependent expression of Drosophila Insulin-like peptide (dilp). We identified the responsible transcription factors that cooperatively control dilp5 gene expression. We also conducted in vivo RNAi screening to identify novel players for the regulation of body growth. We identified a gene that we named SDR. SDR is a new class of secreted Dilp-binding proteins that negatively regulate the function of Dilps and thereby body growth., 23687031

  対象リソースIRI
• 2004, 2005, 04J05818

Social Contribution

Social Contribution

• 内分泌・代謝学共同研究拠点講習会, 17 Nov. 2023, 17 Nov. 2023, Research advise　(Target:　Graduate students, Teachers, Researchers)
• 前橋女子高等学校の学生を対象にしたオープンラボ, 04 Aug. 2023, 04 Aug. 2023, Visiting lecture　(Target:　High school students, Teachers)
• 出前授業, 06 Dec. 2022, 06 Dec. 2022, Visiting lecture　(Target:　High school students)