Integrative Medicine, Professor

Keiko Kawai-Kowase

川合 桂子

Keiko Kowase

Keiko Kawai

Gunma University, Lecturer

Gunma University, Professor

M.D., Ph.D.

M.D., Ph.D.

M.D., Ph.D., Gunnma University School of Medicine

Gunma University

Life sciences, Cardiology

vascular disease

Molecular mechamisms of vascular smooth muscle cells in cardiovascular disease., Institutional Collaboration, Circulatory Organs Internal Medicine, Grant-in-Aid for Scientific Research

A case of anti-MDA5-positive clinically amyopathic dermatomyositis presenting acrodermal erythromelalgia complicated with Basedow’s disease, Akihito Kimura, Norio Horiguchi , Kuniko Yoshida, Mayu Ishizaki, Yukie Endo, Sei-ichiro Motegi, Hiroko Sato, Sakura Kanazashi, Yukako Hirayama, Yoshio Ohyama, Keiko Kawai-Kowase, 2024, JOURNAL OF HOSPITAL GENERAL MEDICINE, 6, 3, 62, 67

骨折治療の遷延により発見されたFGF23関連低リン血症性骨軟化症の1例, 奥野賢一郎、 堀口昇男、佐藤浩子、伊藤あゆみ、加藤昭彦、金指桜子、吉田くに子、新井茉莉、山田英二郎、小和瀬桂子, 2024

バセドウ病及び骨粗鬆症治療薬に起因すると考えられる高カルシウム血症により消化器症状を来した一例., 増田龍樹、金指桜子、佐藤浩子、加藤昭彦、吉田くに子、堀口昇男、関口奨、山田英二郎、小和瀬桂子．, 2024

Comparison of the efficacy of continuous intravenous infusion versus intramuscular injection of epinephrine for initial anaphylaxis treatment, Kenji Fujizuka , Mitsunobu Nakamura , Junichi Tamura2, Keiko Kawai-Kowase, 2022, Acute Med Surg ., 20, 9(1), e790., e790.

Outcomes of Veno-venous extracorporeal membrane oxygenation in eldearly, Jyn Maruyama, Keiko Kawai-Kowase, Yuki Ideno, Kenji Fujizuka, Mitsunobu NAkamura, Junichi Tamura, 2022, Journal of Hospital Generan Medicine, 4, 2, 66, 74

Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Renal-Limited Vasculitis in a Young Adult Woman, Yukihiro Otaka 1 2, Daiki Uchida 1, Kinue Shimizu-Arii 3, Nobuyoshi Ishiyama 1, Keiko Kawai-Kowase 2, 27 Jan. 2022, Cureus, 14, 1, e21654, e21654

突然の腰背部痛・ショックを呈した運動後急性腎障害(ALPE)の一例, 突然の腰背部痛・ショックを呈した運動後急性腎障害(ALPE)の一例(会議録)尾花 裕太, 小和瀬 桂子, 大嶋 清宏, 中島 潤, 澤田 悠輔, 市川 優美, 一色 雄太, 福島 一憲, 荒巻 裕斗, 森 瑞樹, 河野 慧, 2022, 33, 10, 736, 736

多様性に寄り添う総合診療をめざして, 小和瀬桂子, 2022, 72, 3, 291, 292

DPP-4阻害薬であるシタグリプチンの長期内服中に発症したRS3PEの2例, 湯川 奈緒子 大高 行博, 高橋 正樹, 栗原 勇希, 益田 敬明, 大舘 幸太, 堀口 昇男, 佐藤 浩子, 小和瀬 桂子, 田村 遵一, 石山 延吉, 2021, 17, 1, 43, 8

頭部外傷後に尿閉で発症したMeningitis-retention syndromeの一例, 村田 将人, 福島 一憲, 神戸 将彦, 佐藤 浩子, 小和瀬 桂子, 田村 遵一, 大嶋 清宏, Nov. 2021, 31, 11, 1595, 1595

ジェノゲスト療法のみで制御が難しかった月経随伴性気胸の一例, 若松 郁生、原 健一郎, 宇野 翔吾, 笠原 礼光, 山口 公一, 山口 彩, 鶴巻 寛朗, 矢富 正清, 古賀 康彦, 砂長 則明, 小和瀬 桂子, 久田 剛志, 前野 敏孝, Feb. 2021, 179回・243回, 30

Painless isolated spontaneous dissection of the superior mesenteric artery., Otaka Y, Yamaguchi M, Ishiyama N, Kawai-Kowase K., Dec. 2021, BMJ Case Rep., 14, 12, e248122

Evans症候群の治療経過中に血管免疫芽球性T細胞リンパ腫を発症した1例 , 大高 行博,渡邉 俊樹,合田 史,佐藤 真人,佐藤 浩子,小和瀬 桂子,大山 良雄,田村 遵一,佐藤 正通 , 2017, 12, 2, 1-6.

Fibroblast growth factor 23 inhibits osteoblastic gene expression and induces osteoprotegerin in vascular smooth muscle cells, Nakahara, Takehiro; Kawai-Kowase, Keiko; Matsui, Hiroki; Sunaga, Hiroaki; Utsugi, Toshihiro; Iso, Tatsuya; Arai, Masashi; Tomono, Shouichi; Kurabayashi, Masahiko, Oct. 2016, ATHEROSCLEROSIS

ハナをかんだらメがハレた！眼窩気腫の1例, 大嶋 清宏,杉原 由利子,萩原 周一,村田 将人,青木 誠,金子 稔,中島 潤,小和瀬 桂子,田村 遵一, Nov. 2015, 65, 4, 303-306

女性疾患と漢方治療, 佐藤 浩子,佐藤 真人,小和瀬 桂子,金子 尚子,森田 元穂,大山 良雄,田村 遵一, 2014, 7, 2, 25-30

血管石灰化の分子機序, 中原健裕,小和瀬桂子,倉林正彦, 2014, 25, 2, 138-143

「トリグリセライド. 遊離脂肪酸. リポ蛋白とその分画」, 小和瀬 桂子,倉林 正彦, 2014

Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells, Shimizu T, Tanaka T, Iso T, Kawai-Kowase K, Kurabayashi M, Sep. 2012, Int Heart J.

Notch induces myofibroblast differentiation of alveolar epithelial cells via TGF？/Smad3 pathway. , Aoyagi-Ikeda K, Maeno T, Matsui H, Ueno M, Hara K, Aoki F, Shimizu T, Doi H, Kawai-Kowase K, Iso T, Suga T, Arai M, Kurabayashi M., Jun. 2011, Am J Respir Cell Mol Biol.

Notch signaling pathway enhances bone morphogenic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells. , Shimizu T, Tanaka T, Iso T, Matsui H, Ooyama Y, Kawai-Kowase K, Arai M, Kurabayashi M., May 2011, J Biol Chem.

Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells. , Nakahara T, Sato H, Shimizu T, Tanaka T, Matsui H, Kawai-Kowase K, Sato M, Iso T, Arai M, Kurabayashi M. , Apr. 2010, Biochem Biophys Res Commun.

Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells: role of Msx2 gene induction via Notch-RBP-J？？signaling, Shimizu T, Tanaka T, Iso T, Doi H, Sato H, Kawai-Kowase K, Arai M, Kurabayashi M. , Jul. 2009, Arterioscler Thromb Vasc Biol.

PIAS1 mediates TGFbeta-induced SMalpha-actin gene expression though inhibition of KLF4 function-expression by protein sumoylation. , Kawai-Kowase K, Oshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M. , Jan. 2009, Arterioscler Thromb Vasc Biol.

Quantitative analysis of mast cells in benign and malignant colonic lesions: immunohistochemical study on formalin-fixed, paraffin-embedded tissues., Kashiwase Y, Inamura H, Morioka J, Igarashi Y, Kawai-Kowase K, Kurosawa M., Sep. 2008, Allergol Immunopathol

Multiple Repressor Pathways Contribute to Phenotypic Switching of Vascular Smooth Muscle Cells. , Kawai-Kowase K. Owens GK., 2008, Am J Physiol Cell Physiol

Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. , Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M., 2008, Mol Cell Biol

PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins., Kawai-Kowase K, Kumar MS, Hoognagle MH, Yoshida T, Owens GK., Sep. 2005, Mol Cell Biol

Basic fibroblast growth factor antagonizes transforming growth factor-？1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation. , 2004, Arterioscler Thromb Vasc Biol.

Transcriptional Activation of the Zinc Finger Transcription Factor BTEB2 Gene by Egr-1 through Mitogen-Activated Protein Kinase Pathways in Vascular Smooth Muscle Cells. , 1999, Circ Res

Novel deletion on the short arm of chromosome 17 in a patient with multiple cardiac anomalies. , Kowase K, Nakamura T, Okumura W, Okamoto E, Yamaguchi E, Sato H, Arai M, Imai S, Hasegawa A, Nagai R. , 1997, Jpn Circ J

Ischemic heart disease. Advances in diagnosis and treatment II. Advances in diagnosis 4. Biochemical diagnosis of acute myocardial infarction., 小和瀬 桂子;星野 洋一;倉林 正彦;永井 良三, Feb. 2000, Nihon Naika Gakkai Zasshi, 89, 2, 259, 265

BTEB2, a Tissue Restricted Zinc Finger Protein, Regulates Phenotypic Modulation of Vascular Smooth Muscle Cells and Activation of Macrophage, KOWASE K.;KURABAYASHI M.;AKUZAWA N.;HOSHINO Y.;NAGAI R., Feb. 2000, 40, 2, 85, 91

Inducible Expression of BTEB2, a Zinc Finger Transcription Factor, During the Vascular Constriction : Immunohistochemical Analysis, OGATA T;KURABAYASHI M;HOSHINO Y;KOWASE K;OHTAKI A;YAMAGISHI T;KUMAKURA K;ISHIKAWA S;MORISHITA Y;NAGAI R, Aug. 2001, 41, 8, 451, 456

SI-8 血管平滑筋細胞の形質変換因子BTEB2の同定と血管リモデリングにおける役割, 倉林 正彦;星野 洋一;坂本 浩之助;大山 良雄;小和瀬 桂子;神田 享勉;渡辺 徳;真鍋 一郎;下村 行生;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

0553 低酸素刺激は酸化ストレスを介して心筋特異的な遺伝子の発現を変化させる。, 関口 賢一;倉林 正彦;横山 知行;都丸 浩一;新井 昌史;大山 良雄;相原 康;相澤 宏樹;田中 亨;内山 強;小和瀬 桂子;阿久澤 暢洋;神田 享勉;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

0732 ホメオ蛋白HEXは血管平滑筋細胞の形質変換を誘導する, 大山 良雄;倉林 正彦;坂本 浩之助;星野 洋一;相原 康;都丸 浩一;内山 強;阿久澤 暢洋;小和瀬 桂子;田中 亨;関口 賢一;永井 良三;黒尾 誠;下村 行生;真鍋 一郎, Feb. 1998, Japanese circulation journal, 62, 0

0837 Mn-SODプロモーターはc-JunおよびGC結合蛋白との相乗作用により著明に活性化される, 田中 亨;倉林 正彦;相原 康;小和瀬 桂子;阿久澤 暢洋;内山 強;都丸 浩一;関口 賢一;相澤 宏樹;大山 良雄;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

1002 Zinc finger型転写因子BTEB2は血管平滑筋細胞の形質変換因子である., 倉林 正彦;坂本 浩之助;星野 洋一;大山 良雄;相澤 宏樹;相原 康;都丸 浩一;関口 賢一;田中 亨;内山 強;小和瀬 桂子;神田 享勉;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

1053 心筋特異的な核内因子CARPの発現調節と病態生理的意義, 相原 康;倉林 正彦;新井 昌史;大山 良雄;相澤 宏樹;都丸 浩一;関口 賢一;田中 亨;内山 強;小和瀬 桂子;阿久澤 暢洋;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

1058 転写因子Egr-1とEts-1は平滑筋形質変換誘導因子BTEB2遺伝子を活性化する, 小和瀬 桂子;倉林 正彦;坂本 浩之助;星野 洋一;大山 良雄;相澤 宏樹;相原 康;田中 亨;内山 強;阿久澤 暢洋;都丸 浩一;関口 賢一;永井 良三;神田 享勉, Feb. 1998, Japanese circulation journal, 62, 0

1065 転写因子BTEB2は冠動脈再狭窄およびde novo病変にて血管平滑筋細胞の脱分化を誘導する, 坂本 浩之助;倉林 正彦;岡本 栄一;星野 洋一;大山 良雄;相原 康;都丸 浩一;関口 賢一;田中 亨;内山 強;小和瀬 桂子;阿久澤 暢洋;神田 享勉;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

P535 ANPおよびアンギオテンシノーゲン遺伝子の発現調節, 都丸 浩一;倉林 正彦;新井 昌史;横山 知行;大山 良雄;相澤 宏樹;相原 康;関口 賢一;田中 亨;内山 強;小和瀬 桂子;阿久澤 暢洋;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

P594 血管障害部位における血管内皮細胞増殖因子(VEGF)受容体、KDR/Flk-1・Flt-1の発現亢進とその分子機序の解析, 阿久澤 暢洋;倉林 正彦;坂本 浩之助;大山 良雄;相澤 宏樹;相原 康;田中 亨;小和瀬 桂子;内山 強;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

P725 ヒトCARP遺伝子の心筋細胞および内皮細胞特異的プロモーター活性, 相原 康;倉林 正彦;田中 享;都丸 浩一;新井 昌史;大山 良雄;相澤 宏樹;関口 賢一;内山 強;小和瀬 桂子;阿久澤 暢洋;永井 良三, Feb. 1998, Japanese circulation journal, 62, 0

0270 Klotho蛋白が血管内皮細胞機能におよぼす影響, 大山 良雄;内山 強;武田 真一;阿久澤 暢洋;小和瀬 桂子;斉藤 勇一郎;中村 哲也;倉林 正彦;増田 浩明;黒尾 誠;松田 譲;鍋島 陽一;永井 良三, Mar. 2000, Japanese circulation journal, 64, 0

0287 転写因子BTEB2は脱分化血管平滑筋と間質細胞を識別し, 酸化ストレスにより発現が誘導される因子である, 前野 有理;倉林 正彦;前野 敏隆;小和瀬 桂子;永井 良三, Mar. 2000, Japanese circulation journal, 64, 0

0380 ホメオ蛋白Hex遺伝子はTGFβ/SmadおよびGATAにより発現調節される, 大山 裕子;倉林 正彦;関口 賢一;大山 良雄;小和瀬 桂子;永井 良三, Mar. 2000, Japanese circulation journal, 64, 0

0383 平滑筋形質変換誘導因子BTEB2遺伝子の発現誘導・転写活性化能はレチノイン酸により抑制される, 小和瀬 桂子;倉林 正彦;渡辺 直;永井 良三, Mar. 2000, Japanese circulation journal, 64, 0

0993 平滑筋形質変換誘導因子BTEB2は組織因子・PDGF遺伝子発現を正に調節する, 小和瀬 桂子;倉林 正彦;相原 康;関口 賢一;内山 強;大山 裕子;永井 良三, Mar. 2000, Japanese circulation journal, 64, 0

IS034 Inducible Expression of the Hex Homeobox Gene in Vascular Smooth Muscle Cells in Tissue Injury, Sekiguchi Kenichi;Kurabayashi Masahiko;Ohyama Yoshio;Sakamoto Hironosuke;Ohyama Yuko;Kowase Keiko;Watanabe Atai;Manabe Ichiro;Shimomura Yukio;Nagai Ryozo, Mar. 1999, Japanese circulation journal, 63, 1

IS045 Transcription of the BTEB2, a tissue-restricted zinc finger protein, is activated by Egr-1 in vascular smooth muscle cells, Kowase Keiko;Kurabayashi Masahiko;Ohyama Yoshio;Aihara Yasushi;Tanaka Toru;Uchiyama Tsuyoshi;Akuzawa Nobuhiro;Tomaru Koichi;Sekiguchi Kenichi;Sakamoto Hironosuke;Nagai Ryozo, Mar. 1999, Japanese circulation journal, 63, 1

0142 平滑筋形質変換誘導因子BTEB2遺伝子発現は転写遺伝子Eqr-1により活性化し、レチノイン酸により抑制される, 小和瀬 桂子;倉林 正彦;大山 良雄;相原 康;田中 亨;永井 良三, Mar. 1999, Japanese circulation journal, 63, 1

P815 ホメオ蛋白HEX発現の遺伝子クローニングと発現調節, 大山 裕子;倉林 正彦;関口 賢一;大山 良雄;小和瀬 桂子;下村 幸生;永井 良三, Mar. 1999, Japanese circulation journal, 63, 1

Novel Deletion on the Short Arm of Chromosome 17 in a Patient With Multiple Cardiac Anomalies, KOWASE Keiko;NAKAMURA Tetsuya;OKUMURA Wataru;OKAMOTO Eiichi;YAMAGUCHI Etsuo;SATO Hideki;ARAI Masashi;IMAI Susumu;HASEGAWA Akira;NAGAI Ryozo, Sep. 1997, Japanese Circulation Journal, 61, 10, 882, 885

Homeobox protein, Hex, activates the SM22 α promoter through recruiting the SRF to its binding site in murine embryonic fibroblasts, Oyama Yuko;Sekiguchi Kenichi;Ohyama Yoshio;Okamoto Eiichi;Kowase Keiko;Kurabayashi Masahiko, Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 0

Src family of tyrosine kinases and Smads mediate TGF- β - induced smooth muscle cell differentiation in 10T1/2 cells, Sato Mahito;Kowase Keiko;Oyama Yuko;Kanai Hiroyoshi;Sato Hiroko;Kurabayashi Masahiko;Nagai Ryozo, Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 0

Basic FGF interferes with the TGF β -induced SMC gene expression through the inhibition of serum response factor (SRF) function, Kowase Keiko;Oyama Yuko;Kanai Hiroyoshi;Sato Mahito;Kurabayashi Masahiko;Nagai Ryozo, Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 0

PE-231 FGF-2 Changes Vascular Smooth Muscle Cell Fate and Induce Osteoblastic Marker Gene Expression via cbfa1.(Vascular Smooth Muscle 1 (H) : PE40)(Poster Session (English)), Sato Hiroko;Sato Mahito;Kowase Keiko;Oyama Yuko;Saito Yuichiro;Kurabayashi Masahiko, Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 0

KLF5 not only Synergistically Activates PDGF-A Gene with NFκ B but also Accelerates SMC Proliferation, Aizawa Kenichi;Suzuki Toru;Kada Nanae;Mutou Shinsuke;Miyamoto Saku;Nagino Tomoko;Mizuno Yoshiko;Amaki Toshihiro;Fukino Keiko;Imai Yasushi;Manabe Ichiro;Shindou Takayuki;Maemura Kouji;Kowase Keiko;Kurabayashi Masahiko;Nagai Ryozo, Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 0

FGF-2 Induces Osteoblastic Marker Osteopontin Gene Expressionand Inhibits Smooth Muscle Differentiation via Cbfal in Rat Aortic Smooth Muscle Cells, Sato Hiroko;Kowase Keiko;Sato Mahito;Oyama Yuko;Kanai Hiroyoshi;Ohyama Yoshio;Saito Yuichiro;Kurabayashi Masahiko, Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 0

Homeobox Protein, Hex, Induces SM22a Gene Expression by Direct Binding to SRF in Murine Embryonic Fibroblasts, Oyama Yuko;Kowase Keiko;Sekiguchi Kenichi;Ohyama Yoshio;Okamoto Eiichi;Sato Mahito;Kurabayashi Masahiko, Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 0

bFGF Inhibits the TGFβ-Induced SM22α Gene Expression by CBFA1 through MAP Kinase Pathways in Embryonic Fibroblast Cells, Kowase Keiko;Sato Hiroko;Oyama Yuko;Sato Mahito;Kanai Hiroyoshi;Nagai Ryozo;Kurabayashi Masahiko, Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 0, 406, 407

Crosstalk between c-Src- and Smad-Dependent Pathways Regulates the TGF-β-Induced SMC-Specific Gene Expression in Murine Embryonic Fibroblast 10T1/2 Cells, Sato Mahito;Kowase Keiko;Oyama Yuko;Sato Hiroko;Kanai Hiroyoshi;Tamura Junichi;Sakamoto Hironosuke;Nagai Ryozo;Kurabayashi Masahiko, Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 0

FRS-082 Cbfa1 Represses Vascular Smooth Muscle Cells Differentiation by Disrupting the SRF-myocardin Complex(Molecular Biology in Cardiovascular Diseases (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society), Tanaka Toru;Sato Hiroko;Doi Hiroshi;Shimizu Takehisa;Kowase Keiko;Iso Tatsuya;Kurabayashi Masahiko, Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 0

OE-180 PIAS1 Activates TGFβ-induced Smooth Muscle α-actin Gene Expression by Inhibition of KLF4 Function and Protein Sumoylation(Vascular smooth muscle-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society), Kowase Keiko;Iso Tatsuya;Tanaka Toru;Arai Masashi;Owens Gary K;Kurabayashi Masahiko, Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 0

PJ-092 PIAS1 Mediates TGF β-induced SM α-actin Gene Expression through Inhibition of KLF4 Function-expression by Protein Sumoylation(PJ016,Molecular Biology/Genetics, Myocardium, Vascular (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society), Kowase Keiko;Matsui Hiroki;Tanaka Toru;Shimizu Takehisa;Iso Tatsuya;Arai Masashi;Kurabayashi Masahiko, Mar. 2009, Circulation journal : official journal of the Japanese Circulation Society, 73, 0

Orbital Emphysema Complicated with Orbital Fracture::A Case Report, Oshima Kiyohiro;Sugihara Yuriko;Hagiwara Shuichi;Murata Masato;Aoki Makoto;Kaneko Minoru;Nakajima Jun;Kowase Keiko;Tamura Jun-ichi, 2015, The Kitakanto Medical Journal, 65, 4, 303, 306

An Initiative to deal with Gender-Equal Society in Gunma University:- Establishment for Office for Gender Equality in Graduate School of Medicine -, Kowase Keiko;Hatori Reiko;Ishizaki Yasuki, 2018, The Kitakanto Medical Journal, 68, 4, 287, 289

The Curreut State and the Prospect of Emergency Medicine in Gunma University, Oshima Kiyohiro;Fukushima Kazunori;aramaki yuto;Kowase Keiko;Tamura Junichi;Aoki Makoto;Murata Masato;Kanbe Masahiko;Nakajima Jun;Sawada Yusuke;Isshiki Yuta;Ichikawa Yumi;Mishima Kanako, 2019, The Kitakanto Medical Journal, 69, 2, 163, 165

Resumption of Anticoagulant Therapy in a Severe Trauma Patient with a Mechanical Aortic Valve Replacement, Mishima Kanako;Aramaki Yuto;Kowase Keiko;Tamura Jun-ichi;Oshima Kiyohiro;Murata Masato;Aoki Makoto;Kanbe Masahiko;Nakajima Jun;Sawada Yusuke;Isshiki Yuta;Ichikawa Yumi;Fukushima Kazunori, 2019, The Kitakanto Medical Journal, 69, 3, 237, 242

Injuries from Skiing and Snowboarding, Oshima Kiyohiro;Kowase Keiko;Tamura Jun-ichi;Murata Masato;Kanbe Masahiko;Nakajima Jun;Sawada Yusuke;Isshiki Yuta;Ichikawa Yumi;Fukushima Kazunori;Aramaki Yuto, 2020, The Kitakanto Medical Journal, 70, 3, 215, 221

ハナをかんだらメがハレた!　眼窩気腫の1例, ;;;;;;;;, Nov. 2015, 65, 4, 303

移動する皮疹、嚥下困難を主訴に来院し、診断に難渋した不明熱の一例, ;;;;;;;;, Jun. 2016, 10, 2, 177

乗馬外傷の治療経験, ;;;;;;;;;;, Aug. 2016, 66, 3, 258

前頸部痛を主訴として来院し、CTにて石灰沈着を認めなかった頸長筋膜炎の一例, ;;;;;;;, Dec. 2016, 11, 2, 182

超高齢者の低ナトリウム血症が認知症初期集中支援チームの介入を経て改善した1例, ;;;;;;, Dec. 2016, 11, 2, 215

甲状腺機能亢進症に合併した高カルシウム血症による尿管結石の一例, ;;;;;;;;;, Jul. 2017, 13, 1, 120

CRP上昇のため来院し、診断に難渋した多発血管炎性肉芽腫症の一例, ;;;;;;;;;;;;, Jul. 2017, 13, 1, 160

失神の精査を目的に来院し甲状腺機能異常が判明した3症例, ;;;;;;, Jan. 2018, 14, 1, 43

大学病院総合診療部における医学科臨床実習の効果と課題, ;;;;;;, Jan. 2018, 14, 1, 79

群馬大学における男女共同参画推進事業および支援制度　医学系研究科男女共同参画推進委員会の発足, ;;, Nov. 2018, 68, 4, 287

独居高齢者に生じたビタミンB1欠乏症における浮腫症例, ;;;;;;;, Nov. 2018, 14, 6, 620

浮腫を主訴とした高齢者のビタミンB1欠乏症の一症例, ;;;;;;;, Jan. 2019, 15, 1, 12

血液検査及び画像検査で異常を指摘されなかった下腹部痛の3症例, ;;;;;;;;;;, Nov. 2019, 15, 6, 567

るい痩を契機に受診し、診断に苦慮した統合失調症の1例, ;;;;;;;;;, Nov. 2019, 15, 6, 591

低カリウム血症によるミオパチーで発見されたシェーグレン症候群の1例, ;;;;;;, Nov. 2019, 15, 6, 607

腸骨鼡径神経痛3例の検討, ;;;;;;;;;;, May 2020, 16, 3, 141

スキーおよびスノーボード外傷の検討, ;;;;;;;;;;, Aug. 2020, 70, 3, 215

Re-expansion pulmonary edema after thoracentesis for iatrogenic pneumothorax and severe subcutaneous emphysema., Kuribara Yuki;Otaka Yukihiro;Namiki Azusa;Kawai-Kowase Keiko;Tamura Jun'ichi;Ishiyama Nobuyoshi, 28 Oct. 2020, Clinical case reports, 8, 12

Accurate and quick predictor of necrotizing soft tissue infection: Usefulness of the LRINEC score and NSTI assessment score., Harasawa Tomofumi;Kawai-Kowase Keiko;Tamura Jun'ichi;Nakamura Mitsunobu, 08 Nov. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26, 4

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling., Shindo Takayuki;Manabe Ichiro;Fukushima Yasushi;Tobe Kazuyuki;Aizawa Kenichi;Miyamoto Saku;Kawai-Kowase Keiko;Moriyama Nobuo;Imai Yasushi;Kawakami Hayato;Nishimatsu Hiroaki;Ishikawa Takashi;Suzuki Toru;Morita Hiroyuki;Maemura Koji;Sata Masataka;Hirata Yasunobu;Komukai Masayuki;Kagechika Hiroyuki;Kadowaki Takashi;Kurabayashi Masahiko;Nagai Ryozo, Jul. 2002, Nature medicine, 8, 8

Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB., Aizawa Kenichi;Suzuki Toru;Kada Nanae;Ishihara Atsushi;Kawai-Kowase Keiko;Matsumura Takayoshi;Sasaki Kana;Munemasa Yoshiko;Manabe Ichiro;Kurabayashi Masahiko;Collins Tucker;Nagai Ryozo, Oct. 2003, The Journal of biological chemistry, 279, 1

Basic fibroblast growth factor antagonizes transforming growth factor-beta1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation., Kawai-Kowase Keiko;Sato Hiroko;Oyama Yuko;Kanai Hiroyoshi;Sato Mahito;Doi Hiroshi;Kurabayashi Masahiko, Jun. 2004, Arteriosclerosis, thrombosis, and vascular biology, 24, 8

Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells., Yoshida Tadashi;Kawai-Kowase Keiko;Owens Gary K, Jul. 2004, Arteriosclerosis, thrombosis, and vascular biology, 24, 9

Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts., Oyama Yuko;Kawai-Kowase Keiko;Sekiguchi Kenichi;Sato Mahito;Sato Hiroko;Yamazaki Miki;Ohyama Yoshio;Aihara Yasushi;Iso Tatsuya;Okamaoto Eichi;Nagai Ryozo;Kurabayashi Masahiko, Jul. 2004, Arteriosclerosis, thrombosis, and vascular biology, 24, 9

c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells., Sato Mahito;Kawai-Kowase Keiko;Sato Hiroko;Oyama Yuko;Kanai Hiroyoshi;Ohyama Yoshio;Suga Tatsuo;Maeno Toshitaka;Aoki Yasuhiro;Tamura Junichi;Sakamoto Hironosuke;Nagai Ryozo;Kurabayashi Masahiko, Dec. 2004, Arteriosclerosis, thrombosis, and vascular biology, 25, 2

PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins., Kawai-Kowase Keiko;Kumar Meena S;Hoofnagle Mark H;Yoshida Tadashi;Owens Gary K, Molecular and cellular biology, 25, 18

HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box., Doi Hiroshi;Iso Tatsuya;Yamazaki Miki;Akiyama Hideo;Kanai Hiroyoshi;Sato Hiroko;Kawai-Kowase Keiko;Tanaka Toru;Maeno Toshitaka;Okamoto Ei-ichi;Arai Masashi;Kedes Larry;Kurabayashi Masahiko, Sep. 2005, Arteriosclerosis, thrombosis, and vascular biology, 25, 11

Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells., Kawai-Kowase Keiko;Owens Gary K, Sep. 2006, American journal of physiology. Cell physiology, 292, 1

Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells., Tanaka Toru;Sato Hiroko;Doi Hiroshi;Yoshida Carolina A;Shimizu Takehisa;Matsui Hiroki;Yamazaki Miki;Akiyama Hideo;Kawai-Kowase Keiko;Iso Tatsuya;Komori Toshihisa;Arai Masashi;Kurabayashi Masahiko, Nov. 2007, Molecular and cellular biology, 28, 3

PIAS1 mediates TGFbeta-induced SM alpha-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation., Kawai-Kowase Keiko;Ohshima Takayuki;Matsui Hiroki;Tanaka Toru;Shimizu Takehisa;Iso Tatsuya;Arai Masashi;Owens Gary K;Kurabayashi Masahiko, Oct. 2008, Arteriosclerosis, thrombosis, and vascular biology, 29, 1

Notch signaling induces osteogenic differentiation and mineralization of vascular smooth muscle cells: role of Msx2 gene induction via Notch-RBP-Jk signaling., Shimizu Takehisa;Tanaka Toru;Iso Tatsuya;Doi Hiroshi;Sato Hiroko;Kawai-Kowase Keiko;Arai Masashi;Kurabayashi Masahiko, Apr. 2009, Arteriosclerosis, thrombosis, and vascular biology, 29, 7

Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells., Nakahara Takehiro;Sato Hiroko;Shimizu Takehisa;Tanaka Toru;Matsui Hiroki;Kawai-Kowase Keiko;Sato Mahito;Iso Tatsuya;Arai Masashi;Kurabayashi Masahiko, Nov. 2009, Biochemical and biophysical research communications, 394, 2

腸骨鼡径神経痛3例の検討, ;;;;;;;;;;, May 2020, 16, 3, 141

スキーおよびスノーボード外傷の検討, ;;;;;;;;;;, Aug. 2020, 70, 3, 215

頭部外傷後に尿閉で発症したMeningitis-retention syndromeの一例, ;;;;;;, Nov. 2020, 31, 11, 1595

ジェノゲスト療法のみで制御が難しかった月経随伴性気胸の一例, ;;;;;;;;;;;;, Feb. 2021, 179回・243回, 30

Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-{beta}-Smad3 pathway., Aoyagi-Ikeda Kana;Maeno Toshitaka;Matsui Hiroki;Ueno Manabu;Hara Kenichiro;Aoki Yasuhiro;Aoki Fumiaki;Shimizu Takehisa;Doi Hiroshi;Kawai-Kowase Keiko;Iso Tatsuya;Suga Tatsuo;Arai Masashi;Kurabayashi Masahiko, American journal of respiratory cell and molecular biology, 45, 1

Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells., Shimizu Takehisa;Tanaka Toru;Iso Tatsuya;Kawai-Kowase Keiko;Kurabayashi Masahiko, International heart journal, 53, 5

Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells., Shimizu Takehisa;Tanaka Toru;Iso Tatsuya;Matsui Hiroki;Ooyama Yoshiaki;Kawai-Kowase Keiko;Arai Masashi;Kurabayashi Masahiko, Apr. 2011, The Journal of biological chemistry, 286, 21

鍼治療による感染が疑われた化膿性脊椎炎の一例, ;;;;;;;, Sep. 2020, 16, 臨増3, 120

コルヒチンによる炎症コントロール下でロボット支援左腎腫瘍切除術を施行し得た家族性地中海熱の一例, ;;;;;;;;;;;, Feb. 2021, 17, 臨増1, 168

扁桃摘出術後も継続する周期的発熱にファモチジン・シメチジンが有効であった成人発症PFAPA症候群の一例, ;;;;;;;, Sep. 2021, 17, 臨増2, 102

肢端紅痛症様の症状で発症し、Basedow病を合併した無筋症性皮膚筋炎の一例, ;;;;;;;;;;, Sep. 2021, 17, 臨増2, 187

アンカリング及び認知バイアスにより、身体診察や諸検査から上部消化管出血と診断できなかった頻脈の一例, ;;, Sep. 2021, 17, 臨増2, 194

リラクセーション外来におけるリラクセーション技法の有用性についての検討, ;;;;, Aug. 2022, 18, 臨増2, 103

多発骨腫瘍との鑑別に難渋したSystemic cystic angiomatosisの一例, ;;;;;;;;;;;;;, Aug. 2022, 18, 臨増2, 238

COVID-19罹患後症状の3症例　後遺症問診票の活用, ;;;;;;;;, Feb. 2023, 19, 臨増1, 228

インスリン治療開始直後に全身浮腫をきたしたI型糖尿病の一例, ;;;;;;;, Feb. 2023, 19, 臨増1, 263

特徴的な身体所見が診断に役立った神経原性腫瘍の一例, ;;;;;;;;;, Aug. 2023, 19, 臨増2, 152

突然の腰背部痛・ショックを呈した運動後急性腎障害(ALPE)の一例, ;;;;;;;;;;, Oct. 2022, 33, 10, 736

第71回日本東洋医学会学術総会　特別企画「次世代に継ぐ卒前卒後漢方医学教育」　漢方アクティブラーニング　チーム基盤型学習で学ぶ漢方, ;;;;;;;, Jan. 2023, 74, 1, 85

A case of anti-MDA5-positive clinically amyopathic dermatomyositis presenting acrodermal erythromelalgia complicated with Basedow’s disease, KIMURA Akihito; HORIGUCHI Norio; YOSHIDA Kuniko; ISHIZAKI Mayu; ENDO Yukie; MOTEGI Sei-ichiro; SATO Hiroko; KANAZASHI Sakura; HIRAYAMA Yukako; OHYAMA Yoshio; KAWAI-KOWASE Keiko, 2024, Journal of Hospital General Medicine (Web), 6, 3

Myeloperoxidase Antineutrophil Cytoplasmic Antibody-Associated Renal-Limited Vasculitis in a Young Adult Woman., Yukihiro Otaka; Daiki Uchida; Kinue Shimizu-Arii; Nobuyoshi Ishiyama; Keiko Kawai-Kowase, Jan. 2022, Cureus, 14, 1, e21654, Scientific journal

Comparison of the efficacy of continuous intravenous infusion versus intramuscular injection of epinephrine for initial anaphylaxis treatment., Kenji Fujizuka; Mitsunobu Nakamura; Junichi Tamura; Keiko Kawai-Kowase, 2022, Acute medicine & surgery, 9, 1, e790, Scientific journal

Painless isolated spontaneous dissection of the superior mesenteric artery., Yukihiro Otaka; Masakazu Yamaguchi; Nobuyoshi Ishiyama; Keiko Kawai-Kowase, 27 Dec. 2021, BMJ case reports, 14, 12, Scientific journal

Re-expansion pulmonary edema after thoracentesis for iatrogenic pneumothorax and severe subcutaneous emphysema., Yuki Kuribara; Yukihiro Otaka; Azusa Namiki; Keiko Kawai-Kowase; Jun'ichi Tamura; Nobuyoshi Ishiyama, Dec. 2020, Clinical case reports, 8, 12, 3649, 3651, Scientific journal

The use of Kampo in community medicine(和訳中), Sato Hiroko; Sato Mahito; Kawai-Kowase Keiko; Oku Yuko; Horiguchi Norio; Ohyama Yoshio; Tamura Jun'ichi, Jul. 2020, Journal of Hospital General Medicine, 2, 4, 104, 110

Persistent Right Upper Quadrant Pain due to Fitz-Hugh Curtis Syndrome Successfully Treated with Supportive Use of Saireito(和訳中), Sato Hiroko; Honjo Hiroaki; Sato Mahito; Kawai-Kowase Keiko; Uehara Daisuke; Higa Ken; Oku Yuko; Horiguchi Norio; Kanazashi Sakura; Ohyama Yoshio; Tamura Jun'ichi, Jul. 2020, Journal of Hospital General Medicine, 2, 4, 111, 116

腸骨鼡径神経痛3例の検討, 金指 桜子; 小和瀬 桂子; 奥 裕子; 廣木 忠直; 山田 真紀子; 堀口 昇男; 佐藤 浩子; 佐藤 真人; 金子 尚子; 大山 良雄; 田村 遵一, May 2020, 16, 3, 141, 146

Accurate and quick predictor of necrotizing soft tissue infection: Usefulness of the LRINEC score and NSTI assessment score., Tomofumi Harasawa; Keiko Kawai-Kowase; Jun'ichi Tamura; Mitsunobu Nakamura, Apr. 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26, 4, 331, 334, Scientific journal

るい痩を契機に受診し、診断に苦慮した統合失調症の1例, 金指 桜子; 小和瀬 桂子; 福田 正人; 奥 裕子; 佐藤 浩子; 堀口 昇男; 佐藤 真人; 金子 尚子; 大山 良雄; 田村 遵一, Nov. 2019, 15, 6, 591, 591

血液検査及び画像検査で異常を指摘されなかった下腹部痛の3症例, 金指 桜子; 小和瀬 桂子; 廣木 忠直; 山田 真紀子; 奥 裕子; 佐藤 浩子; 堀口 昇男; 佐藤 真人; 金子 尚子; 大山 良雄; 田村 遵一, Nov. 2019, 15, 6, 567, 567

Resumption of Anticoagulant Therapy in a Severe Trauma Patient with a Mechanical Aortic Valve Replacement, 三嶋奏子; 三嶋奏子; 村田将人; 村田将人; 青木誠; 青木誠; 神戸将彦; 神戸将彦; 中島潤; 中島潤; 澤田悠輔; 澤田悠輔; 一色雄太; 一色雄太; 市川優美; 市川優美; 福島一憲; 福島一憲; 荒巻裕斗; 荒巻裕斗; 小和瀬桂子; 小和瀬桂子; 田村遵一; 田村遵一; 大嶋清宏; 大嶋清宏, Aug. 2019, Kitakanto Medical Journal, 69, 3, 237, 242

Adult hypophosphatasia with compound heterozygous p.Phe327Leu missense and c.1559delT frameshift mutations in tissue-nonspecific alkaline phosphatase gene: a case report., Kazunori Fukushima; Keiko Kawai-Kowase; Yukio Yonemoto; Makoto Fujiwara; Hiroko Sato; Mahito Sato; Takuo Kubota; Keiichi Ozono; Junich Tamura, 24 Apr. 2019, Journal of medical case reports, 13, 1, 101, 101, Scientific journal

失神の精査を目的に来院し甲状腺機能異常が判明した3症例, 福島 一憲; 佐藤 浩子; 佐藤 真人; 小和瀬 桂子; 金子 尚子; 大山 良雄; 田村 遵一, Jan. 2018, 14, 1, 43, 43

成人型低ホスファターゼ症の一例, 福島 一憲; 小和瀬 桂子; 米本 由木夫; 藤原 誠; 佐藤 浩子; 佐藤 真人; 金子 尚子; 大山 良雄; 大薗 恵一; 田村 遵一, Jul. 2017, 13, 1, 148, 148

Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-{beta}-Smad3 pathway., Kana Aoyagi-Ikeda; Toshitaka Maeno; Hiroki Matsui; Manabu Ueno; Kenichiro Hara; Yasuhiro Aoki; Fumiaki Aoki; Takehisa Shimizu; Hiroshi Doi; Keiko Kawai-Kowase; Tatsuya Iso; Tatsuo Suga; Masashi Arai; Masahiko Kurabayashi, Jul. 2011, American journal of respiratory cell and molecular biology, 45, 1, 136, 44, Scientific journal

Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells., Tadashi Yoshida; Keiko Kawai-Kowase; Gary K Owens, Sep. 2004, Arteriosclerosis, thrombosis, and vascular biology, 24, 9, 1596, 601, Scientific journal

Homeobox protein Hex facilitates serum responsive factor-mediated activation of the SM22alpha gene transcription in embryonic fibroblasts., Oyama Y; Kawai-Kowase K; Sekiguchi K; Sato M; Sato H; Yamazaki M; Ohyama Y; Aihara Y; Iso T; Okamaoto E; Nagai R; Kurabayashi M, Sep. 2004, Arteriosclerosis, thrombosis, and vascular biology, 24, 9, 1602, 1607, Scientific journal

Regulation of platelet-derived growth factor-A chain by Krüppel-like factor 5: new pathway of cooperative activation with nuclear factor-kappaB., Aizawa K; Suzuki T; Kada N; Ishihara A; Kawai-Kowase K; Matsumura T; Sasaki K; Munemasa Y; Manabe I; Kurabayashi M; Collins T; Nagai R, Jan. 2004, The Journal of biological chemistry, 279, 1, 70, 76

KLF5/BTEB2, a Kruppel-like transcription factor, regulates smooth muscle phenotypic modulation, R Nagai; T Shindo; Manabe, I; T Suzuki; K Aizawa; S Miyamoto; S Muto; K Kawai-Kowase; M Kurabayashi, 2003, SIGNAL TRANSDUCTION AND CARDIAC HYPERTROPHY, 7, 417, 423, International conference proceedings

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling., Shindo T; Manabe I; Fukushima Y; Tobe K; Aizawa K; Miyamoto S; Kawai-Kowase K; Moriyama N; Imai Y; Kawakami H; Nishimatsu H; Ishikawa T; Suzuki T; Morita H; Maemura K; Sata M; Hirata Y; Komukai M; Kagechika H; Kadowaki T; Kurabayashi M; Nagai R, Aug. 2002, Nature medicine, 8, 8, 856, 863

Inducible expression of basic transcription factor binding protein 2 plays a potential role in the development of the allograft vascular disease., T Ogata; R Nagai; M Kurabayashi; Y Hoshino; K Sekiguchi; K Kowase; A Akuzawa; S Ishikawa; I Takeyoshi; Y Morishita, Feb. 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 20, 2, 228, 228, Scientific journal

Regulated expression of the BTEB2 transcription factor in vascular smooth muscle cells: analysis of developmental and pathological expression profiles shows implications as a predictive factor for restenosis., Hoshino Y; Kurabayashi M; Kanda T; Hasegawa A; Sakamoto H; Okamoto E; Kowase K; Watanabe N; Manabe I; Suzuki T; Nakano A; Takase S; Wilcox JN; Nagai R, Nov. 2000, Circulation, 102, 20, 2528, 2534

Ischemic heart disease. Advances in diagnosis and treatment II. Advances in diagnosis 4. Biochemical diagnosis of acute myocardial infarction., 小和瀬 桂子; 星野 洋一; 倉林 正彦; 永井 良三, 10 Feb. 2000, Nihon Naika Gakkai Kaishi, 89, 2, 259, 265, Scientific journal

BTEB2, a Krüppel-like transcription factor, regulates expression of the SMemb/Nonmuscle myosin heavy chain B (SMemb/NMHC-B) gene., Watanabe N; Kurabayashi M; Shimomura Y; Kawai-Kowase K; Hoshino Y; Manabe I; Watanabe M; Aikawa M; Kuro-o M; Suzuki T; Yazaki Y; Nagai R, Jul. 1999, Circulation research, 85, 2, 182, 191

Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells, Toru Tanaka; Hiroko Sato; Hiroshi Doi; Carolina A. Yoshida; Takehisa Shimizu; Hiroki Matsui; Miki Yamazaki; Hideo Akiyama; Keiko Kawai-Kowase; Tatsuya Iso; Toshihisa Komori; Masashi Arai; Masahiko Kurabayashi, Feb. 2008, MOLECULAR AND CELLULAR BIOLOGY, 28, 3, 1147, 1160

Notch Signaling Induces Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells Role of Msx2 Gene Induction via Notch-RBP-Jk Signaling, Takehisa Shimizu; Toru Tanaka; Tatsuya Iso; Hiroshi Doi; Hiroko Sato; Keiko Kawai-Kowase; Masashi Arai; Masahiko Kurabayashi, Jul. 2009, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29, 7, 1104, U186

Notch Signaling Induces Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells Role of Msx2 Gene Induction via Notch-RBP-Jk Signaling, Takehisa Shimizu; Toru Tanaka; Tatsuya Iso; Hiroshi Doi; Hiroko Sato; Keiko Kawai-Kowase; Masashi Arai; Masahiko Kurabayashi, Jul. 2009, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29, 7, 1104, U186

PIAS1 Mediates TGF beta-Induced SM alpha-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation, Keiko Kawai-Kowase; Takayuki Ohshima; Hiroki Matsui; Toru Tanaka; Takehisa Shimizu; Tatsuya Iso; Masashi Arai; Gary K. Owens; Masahiko Kurabayashi, Jan. 2009, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 29, 1, 99, 106

Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells, Takehiro Nakahara; Hiroko Sato; Takehisa Shimizu; Toru Tanaka; Hiroki Matsui; Keiko Kawai-Kowase; Mahito Sato; Tatsuya Iso; Masashi Arai; Masahiko Kurabayashi, Apr. 2010, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394, 2, 243, 248

Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells, Keiko Kawai-Kowase; Gary K. Owens, Jan. 2007, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 292, 1, C59, C69

PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins, K Kawai-Kowase; MS Kumar; MH Hoofnagle; T Yoshida; GK Owens, Sep. 2005, MOLECULAR AND CELLULAR BIOLOGY, 25, 18, 8009, 8023

Transcriptional activation of the zinc finger transcription factor BTEB2 gene by Egr-1 through mitogen-activated protein kinase pathways in vascular smooth muscle cells, K Kawai-Kowase; H Kurabayashi; Y Hoshino; Y Ohyama; R Nagai, Oct. 1999, CIRCULATION RESEARCH, 85, 9, 787, 795

Basic fibroblast growth factor antagonizes transforming growth factor-beta 1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation, K Kawai-Kowase; H Sato; Y Oyama; H Kanai; M Sato; H Doi; M Kurabayashi, Aug. 2004, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 24, 8, 1384, 1390

Basic fibroblast growth factor antagonizes transforming growth factor-beta 1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation, K Kawai-Kowase; H Sato; Y Oyama; H Kanai; M Sato; H Doi; M Kurabayashi, Aug. 2004, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 24, 8, 1384, 1390

Fibroblast growth factor 23 inhibits osteoblastic gene expression and induces osteoprotegerin in vascular smooth muscle cells, Takehiro Nakahara; Keiko Kawai-Kowase; Hiroki Matsui; Hiroaki Sunaga; Toshihiro Utsugi; Tatsuya Iso; Masashi Arai; Shouichi Tomono; Masahiko Kurabayashi, Oct. 2016, ATHEROSCLEROSIS, 253, 102, 110

Notch Signaling Pathway Enhances Bone Morphogenetic Protein 2 (BMP2) Responsiveness of Msx2 Gene to Induce Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells, Takehisa Shimizu; Toru Tanaka; Tatsuya Iso; Hiroki Matsui; Yoshiaki Ooyama; Keiko Kawai-Kowase; Masashi Arai; Masahiko Kurabayashi, May 2011, JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 21, 19138, 19148

Evans症候群の治療経過中に血管免疫芽球性T細胞リンパ腫を発症した1例, 大高 行博,渡邉 俊樹,合田 史,佐藤 真人,佐藤 浩子,小和瀬 桂子,大山 良雄,田村 遵一,佐藤 正通, 2017, 12, 2, 1-6.

Orbital Emphysema Complicated with Orbital Fracture: A Case Report, 大嶋清宏; 大嶋清宏; 杉原由利子; 萩原周一; 萩原周一; 村田将人; 村田将人; 青木誠; 青木誠; 金子稔; 金子稔; 中島潤; 中島潤; 小和瀬桂子; 田村遵一, 2015, Kitakanto Medical Journal, 65, 4, 303, 306

「トリグリセライド. 遊離脂肪酸. リポ蛋白とその分画」, 小和瀬 桂子,倉林 正彦, 2014

女性疾患と漢方治療, 佐藤 浩子,佐藤 真人,小和瀬 桂子,金子 尚子,森田 元穂,大山 良雄,田村 遵一, 2014, 7, 2, 25, 30

血管石灰化の分子機序, 中原健裕,小和瀬桂子,倉林正彦, 2014, 25, 2, 138, 143

Azelnidipine Inhibits Msx2-Dependent Osteogenic Differentiation and Matrix Mineralization of Vascular Smooth Muscle Cells, SHIMIZU Takehisa; TANAKA Toru; ISO Tatsuya; ISO Tatsuya; KAWAI-KOWASE Keiko; KURABAYASHI Masahiko, 2012, International Heart Journal, 53(5), 5, 331, 5

Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells, Shimizu T,Tanaka T,Iso T,Kawai-Kowase K,Kurabayashi M, 2012, Int Heart J., 53(5), 5, 331, 5

Notch induces myofibroblast differentiation of alveolar epithelial cells via TGF？/Smad3 pathway., Aoyagi-Ikeda K,Maeno T,Matsui H,Ueno M,Hara K,Aoki F,Shimizu T,Doi H,Kawai-Kowase K,Iso T,Suga T,Arai M,Kurabayashi M, 2011, 45(1):136-44, 136, 144

Notch induces myofibroblast differentiation of alveolar epithelial cells via TGF？/Smad3 pathway., Aoyagi-Ikeda K,Maeno T,Matsui H,Ueno M,Hara K,Aoki F,Shimizu T,Doi H,Kawai-Kowase K,Iso T,Suga T,Arai M,Kurabayashi M, 2011, Am J Respir Cell Mol Biol., 45(1):136-44, 136, 144

Quantitative analysis of mast cells in benign and malignant colonic lesions: immunohistochemical study on formalin-fixed, paraffin-embedded tissues., Kashiwase Y,Inamura H,Morioka J,Igarashi Y,Kawai-Kowase K,Kurosawa M, 2008, 36(5)

Quantitative analysis of mast cells in benign and malignant colonic lesions: immunohistochemical study on formalin-fixed, paraffin-embedded tissues., Kashiwase Y,Inamura H,Morioka J,Igarashi Y,Kawai-Kowase K,Kurosawa M, 2008, Allergol Immunopathol, 36(5)

Novel deletion on the short arm of chromosome 17 in a patient with multiple cardiac anomalies., Kowase K,Nakamura T,Okumura W,Okamoto E,Yamaguchi E,Sato H,Arai M,Imai S,Hasegawa A,Nagai R, 1997, 6, 882, 885

Novel deletion on the short arm of chromosome 17 in a patient with multiple cardiac anomalies., Kowase K,Nakamura T,Okumura W,Okamoto E,Yamaguchi E,Sato H,Arai M,Imai S,Hasegawa A,Nagai R, 1997, Jpn Circ J, 6, 882, 885

特集 -知ってるつもり? 知らなきゃいけない?-新語･新概念辞典 【総論】 一目でわかる新語･新概念, 片岡 仁美; 小和瀬 桂子; 塩谷 昭子; 狩山 和也; 金子 猛; 矢部 大介; 大塚 文男; 柳田 素子; 吉田 雄介; 髙折 晃史; 生野 真嗣; 福島 伸乃介; 若林 秀隆, 15 Feb. 2025, 35, 2, 128, 130

鍼治療による血流感染が疑われた化膿性脊椎炎の1 例, 伊藤 あゆみ; 堀口 昇男; 佐藤 浩子; 奥 裕子; 金指 桜子; 小和瀬 桂子, 2025, 21, 2, 46, 52

Fantastic Four, 吉田くに子; 小和瀬桂子, 2025, 総合診療, 35, 2, 178, 179

HFmrEF,HFrecEF, 吉田くに子; 小和瀬桂子, 2025, 総合診療, 35, 2, 182, 182

バセドウ病及び骨粗鬆症治療薬に起因すると考えられる高カルシウム血症により消化器症状を来した一例, 増田龍樹; 増田龍樹; 金指桜子; 佐藤浩子; 加藤昭彦; 吉田くに子; 堀口昇男; 関口奨; 山田英二郎; 大山良雄; 小和瀬桂子, 2024, 20

骨折治癒の遷延により発見されたFGF23関連低リン血症性骨軟化症の一例, 奥野賢一郎; 奥野賢一郎; 堀口昇男; 佐藤浩子; 伊藤あゆみ; 加藤昭彦; 金指桜子; 吉田くに子; 新井茉莉; 山田英二郎; 大山良雄; 小和瀬桂子, 2024, 20

家族への詳細な病歴聴取が診断の一助となった自己免疫性脳炎の一例, 神澤祐実; 神澤祐実; 吉田くに子; 佐藤浩子; 伊藤あゆみ; 木村彰仁; 平山結佳子; 堀口昇男; 岡大典; 塚越設貴; 小和瀬桂子, 2024, 20

Active Learning, Team-Based Learning (TBL) in Kampo Medicine, 佐藤浩子; 岸美紀子; 常川勝彦; 渡辺由佳子; 小和瀬桂子; 間宮敬子; 高山真; 三潴忠道, 2023, 日本東洋医学雑誌, 74, 1

COVID-19罹患後症状の3症例~後遺症問診票の活用, 佐藤浩子; 堀口昇男; 加藤昭彦; 加藤昭彦; 高橋朋宏; 高橋朋宏; 木村彰仁; 木村彰仁; 平山結佳子; 平山結佳子; 金指桜子; 大山良雄; 大山良雄; 小和瀬桂子, 2023, 19

インスリン治療開始直後に全身浮腫をきたしたI型糖尿病の一例, 加藤昭彦; 加藤昭彦; 佐藤浩子; 反町秀美; 堀口昇男; 平山結佳子; 平山結佳子; 金指桜子; 大山良雄; 大山良雄; 小和瀬桂子, 2023, 19

「埼玉・群馬の健康と医療を支える未来医療人の育成事業」について, 小和瀬桂子; 羽鳥麗子; 岸美紀子; 田中和美; 小山徹也, 2023, 902

特徴的な身体所見が診断に役立った神経原性腫瘍の一例, 渡辺由佳子; 渡辺由佳子; 高橋朋宏; 高橋朋宏; 佐藤浩子; 柳川天志; 平山恭平; 平山恭平; 金指桜子; 吉田くに子; 堀口昇男; 大山良雄; 小和瀬桂子, 2023, 19

Our Goal of Comprehensive Medical Care Including Diversity, Kowase Keiko, 01 Aug. 2022, The Kitakanto Medical Journal, 72, 3, 291, 292

多発骨腫瘍との鑑別に難渋したSystemic cystic angiomatosisの一例, 佐藤浩子; 平澤裕美; 江原雅之; 吉原晃生; 柳川天志; 堀口昇男; 金指桜子; 平山結佳子; 平山結佳子; 加藤昭彦; 加藤昭彦; 高橋朋宏; 高橋朋宏; 木村彰仁; 大高行博; 大高行博; 大山良雄; 小和瀬桂子, 2022, 18

リラクセーション外来におけるリラクセーション技法の有用性についての検討, 平山結佳子; 平山結佳子; 平山結佳子; 柳奈津子; 佐藤浩子; 堀口昇男; 小和瀬桂子, 2022, 18

倦怠感,体重減少,息切れを主訴に受診し,少量ステロイド内服が著効した腸間膜脂肪織炎の一例, 柴田実央子; 木村彰仁; 佐藤正通; 飯塚尭; 植原大介; 小和瀬桂子, 2022, 18

扁桃摘出術後も継続する周期的発熱にファモチジン・シメチジンが有効であった成人発症PFAPA症候群の一例, 平山結佳子; 佐藤浩子; 堀口昇男; 吉田くに子; 金指桜子; 高橋朋宏; 大山良雄; 小和瀬桂子, 2021, 17

アンカリング及び認知バイアスにより,身体診察や諸検査から上部消化管出血と診断できなかった頻脈の一例, 木村彰仁; 田村耕成; 小和瀬桂子, 2021, 17

肢端紅痛症様の症状で発症し,Basedow病を合併した無筋症性皮膚筋炎の一例, 木村彰仁; 吉田くに子; 石崎真由; 遠藤雪惠; 佐藤浩子; 堀口昇男; 金指桜子; 平山結佳子; 高橋朋宏; 高橋朋宏; 大山良雄; 小和瀬桂子, 2021, 17

Injuries from Skiing and Snowboarding, 大嶋清宏; 大嶋清宏; 村田将人; 村田将人; 神戸将彦; 神戸将彦; 中島潤; 中島潤; 澤田悠輔; 澤田悠輔; 一色雄太; 一色雄太; 市川優美; 市川優美; 福島一憲; 福島一憲; 荒巻裕斗; 荒巻裕斗; 小和瀬桂子; 小和瀬桂子; 田村遵一; 田村遵一, 2020, Kitakanto Medical Journal, 70, 3

症例報告 浮腫を主訴とした高齢者のビタミンB₁欠乏症の一症例, 金指 桜子; 小和瀬 桂子; 奥 裕子; 佐藤 浩子; 佐藤 真人; 金子 尚子; 大山 良雄; 田村 遵一, 31 Jan. 2019, JAPANESE JOURNAL OF HOSPITAL GENERAL MEDICINE, 15, 1, 12, 17

The Curreut State and the Prospect of Emergency Medicine in Gunma University, 大嶋清宏; 大嶋清宏; 青木誠; 青木誠; 村田将人; 村田将人; 神戸将彦; 神戸将彦; 中島潤; 中島潤; 澤田悠輔; 澤田悠輔; 一色雄太; 一色雄太; 市川優美; 市川優美; 三嶋奏子; 三嶋奏子; 福島一憲; 福島一憲; 荒巻裕斗; 荒巻裕斗; 小和瀬桂子; 小和瀬桂子; 田村遵一; 田村遵一, 2019, Kitakanto Medical Journal, 69, 2

An Initiative to deal with Gender-Equal Society in Gunma University- Establishment for Office for Gender Equality in Graduate School of Medicine -, Kowase Keiko; Hatori Reiko; Ishizaki Yasuki, 01 Nov. 2018, The Kitakanto Medical Journal, 68, 4, 287, 289

Bone Morphogenetic Protein-2 (BMP-2) and BMP-7 Act as Instructive Factors to Specify Notch Signaling Controlling Smooth Muscle Cell Phenotype, Takehisa Shimizu; Toru Tanaka; Tatsuya Iso; Keiko Kawai-Kowase; Masahiko Kurabayashi, Nov. 2009, CIRCULATION, 120, 18, S1114, S1114, Summary international conference

基礎医学から 動脈硬化と遺伝子多型, 小和瀬 桂子; 阿部 修三; 黒沢 元博, 11 Apr. 2009, 4433, 61, 63

Osteogenic Transcription Factor Runx2 Suppresses Atrial and B-Type Natriuretic Peptide Gene Expression in Rat Cardiacmyocytes: Possible Role of Runx2 in Cardiac Fibrosis, Takehim Nakahara; Takehisa Shimizu; Keiko Kawai-Kowase; Toru Tanaka; Tatsuya Iso; Masashi Arai; Masahiko Kurabayashi, Oct. 2008, CIRCULATION, 118, 18, S1026, S1026, Summary international conference

4 Vascular Calcification : Pathogenesis and Potential Treatment(AHA-JCS Joint Symposium (AHA-JCS Joint Symposium) (IHD) Vulnerable Plaques : Pathogenesis and Noninvasive Approaches to Detection,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society), Shimzu Takehisa; Tanaka Toru; Iso Tatsuya; Suga Toshihiro; Kawai-Kowase Keiko; Sato Hiroko; Arai Masashi; Kurabayashi Masahiko, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 70, 70

海外ラボ紹介(第2回)Cardiovascular Research Center, University of Virginia, 小和瀬 桂子, Oct. 2005, 1, 2, 210, 215

HERP1 inhibits myocardin-induced vascular smooth muscle cell differentiation by interfering with SRF binding to CArG box., Okamoto E; Yamazaki M; Kanai H; KURABAYASHI MASAHIKO; Kedes L; DOI HIROSHI; ISO TATSUYA; SATO HIROKO; TANAKA TOORU; MAENO TOSHITAKA; ARAI MASASHI; AKIYAMA H; KAWAI-KOWASE K, 2005, Arterioscler. Thromb. Vasc. Biol., 25:2328-2334, 11, 2328, 34

c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells, MAENO TOSHITAKA; TAMURA J; SAKAMOTO H; NAGAI R; SATO M; KAWAI; KOWASE K; SATO H; OYAMA Y; KANAI H; OHYAMA Y; SUGA T; AOYI Y, 2005, Arterioscler Thromb Vasc Biol., 25(2):341-7, 2, 341, 7

心筋梗塞様所見で発症した悪性リンパ腫の1症例(第188回日本循環器学会関東甲信越地方会), 樋口 京介; 小和瀬 桂子; 広井 知歳; 池田 士郎; 今成 哲朗; 福田 丈了, 20 Oct. 2003, 67, 928

Phenotypic modulation of vascular smooth muscle cells: dissection of transcriptional regulatory mechanisms., R Nagai; T Suzuki; K Aizawa; S Miyamoto; T Amaki; K Kawai-Kowase; K I Sekiguchi; M Kurabayashi, Dec. 2001, Annals of the New York Academy of Sciences, 947, 56, 66

Inducible expression of basic transcription factor-binding protein 2 (BTEB2), a member of zinc finger family of transcription factors, in cardiac allograft vascular disease., T Ogata; M Kurabayashi; Y I Hoshino; K I Sekiguchi; K Kawai-Kowase; S Ishikawa; Y Morishita; R Nagai, 15 Dec. 2000, Transplantation, 70, 11, 1653, 6

0993 平滑筋形質変換誘導因子BTEB2は組織因子・PDGF遺伝子発現を正に調節する, 小和瀬 桂子; 倉林 正彦; 相原 康; 関口 賢一; 内山 強; 大山 裕子; 永井 良三, 01 Mar. 2000, 64, 434

0380 ホメオ蛋白Hex遺伝子はTGFβ/SmadおよびGATAにより発現調節される, 大山 裕子; 倉林 正彦; 関口 賢一; 大山 良雄; 小和瀬 桂子; 永井 良三, 01 Mar. 2000, 64, 280

0287 転写因子BTEB2は脱分化血管平滑筋と間質細胞を識別し, 酸化ストレスにより発現が誘導される因子である, 前野 有理; 倉林 正彦; 前野 敏隆; 小和瀬 桂子; 永井 良三, 01 Mar. 2000, 64, 256

0383 平滑筋形質変換誘導因子BTEB2遺伝子の発現誘導・転写活性化能はレチノイン酸により抑制される, 小和瀬 桂子; 倉林 正彦; 渡辺 直; 永井 良三, 01 Mar. 2000, 64, 281

BTEB2, a Tissue Restricted Zinc Finger Protein, Regulates Phenotypic Modulation of Vascular Smooth Muscle Cells and Activation of Macrophage, KOWASE K.; KURABAYASHI M.; AKUZAWA N.; HOSHINO Y.; NAGAI R., 25 Feb. 2000, 40, 2, 85, 91

急性心筋梗塞の生化学的診断, 小和瀬桂子, 2000, 89, 53, 59

P815 ホメオ蛋白HEX発現の遺伝子クローニングと発現調節, 大山 裕子; 倉林 正彦; 関口 賢一; 大山 良雄; 小和瀬 桂子; 下村 幸生; 永井 良三, 01 Mar. 1999, 63, 1, 654

0142 平滑筋形質変換誘導因子BTEB2遺伝子発現は転写遺伝子Eqr-1により活性化し、レチノイン酸により抑制される, 小和瀬 桂子; 倉林 正彦; 大山 良雄; 相原 康; 田中 亨; 永井 良三, 01 Mar. 1999, 63, 1, 183

Identification of Transcription Factors Regulating Phenotypic Modulation of Vascular Smooth Muscle Cells, KURABAYASHI Masahiko; KOWASE Keiko; WATANABE Noboru; HOSHINO Yo-ichi; SAKAMOTO Hironosuke; NAGAI Ryozo, 01 Dec. 1998, 21, 189

新・検査値の見方, 2014

CRP上昇のため来院し、診断に難渋した多発血管炎性肉芽腫症の一例, 第14回 日本病院総合診療医学会学術総会, 2017

成人型低ホスファターゼ症の一例, 第14回 日本病院総合診療医学会学術総会, 2017

甲状腺機能亢進症に合併した高カルシウム血症による尿管結石の一例, 第14回 日本病院総合診療医学会学術総会, 2017

失神の精査を目的に来院し甲状腺機能異常が判明した3症例, 第15回 日本病院総合診療医学会学術総会, 2017

大学病院総合診療部における医学科臨床実習の効果と課題, 第15回 日本病院総合診療医学会学術総会, 2017

頸部痛、胸部絞扼感で発症した特発性縦隔気腫の2例, 第15回 日本病院総合診療医学会学術総会, 2017

前頸部痛を主訴として来院し、CTにて石灰沈着を認めなかった頸長筋腱炎の一例, 第13回日本病院総合診療医学会学術総会, 2016

超高齢者の低ナトリウム血症が認知症初期集中支援チームの介入を経て改善した一例, 第13回日本病院総合診療医学会学術総会, 2016

クロピドグレル内服中に亜急性ステント血栓症を発症し、プラスグレルへの変更で血栓症を防止できた一例, 第13回日本病院総合診療医学会学術総会, 2016

移動する皮疹、嚥下困難を主訴に来院し、診断に難渋した不明熱の一例, 第１２回日本病院総合診療医学会学術集会, 2016

Serum FABP4 levels are associated with pericardial adipose tissue volume and plaque characteristics in patients with type 2 diabetes mellitus, 78th Annual Scientific meeting of Japanese Circulation Society, 2014

Evidence for a protective role of Fibroblast Growth Factor 23 against vascular calcification., 78th Annual Scientific meeting of Japanese Circulation Society Featured Research Session, 2014

精神疾患として診断や治療を受けていたバセドウ病の3症例, 第9回 日本病院総合診療医学会学術総会, 2014

体重減少を主訴に来院し、高フェリチン血症が抗甲状腺薬の投与により正常化したバセドウ病の1例, 第9回 日本病院総合診療医学会学術総会 （9月19日～20日）, 2014

Serum FABP4 levels are associated with pericardial adipose tissue volume and plaque characteristics in patients with type 2 diabetes mellitus, 78th Annual Scientific meeting of Japanese Circulation Society, 2014

Evidence for a protective role of Fibroblast Growth Factor 23 against vascular calcification., 78th Annual Scientific meeting of Japanese Circulation Society Featured Research Session, 2014

顔面を含めた左半身のしびれに対し香蘇散が著効した1例, 第7回日本病院総合診療医学会学術総会（平成25年8月30日～31日）（, 2013

Fibroblast growth factor 23 plays a protective role against vascular calcification., ESC Congress, 2013

2型糖尿病患者において血清脂肪酸結合蛋白(FABP)4濃度は心外膜脂肪と相関し、心臓ＣＴ上の不安定プラーク指標と関連する, 日本心臓病学会学術集会, 2013

Association Between Serum Fabp4 Levels, Pericardial Adipose Tissue Volume, And Plaque Characteristics In Patients With Type 2 Diabetes Mellitus, American Heart Association Scientific Session, 2013

A protective role of Fibroblast growth factor 23 against vascular calcification., American Heart Association Scientific Session, 2013

Fibroblast growth factor 23 plays a protective role against vascular calcification., ESC Congress, 2013

Association Between Serum Fabp4 Levels, Pericardial Adipose Tissue Volume, And Plaque Characteristics In Patients With Type 2 Diabetes Mellitus, American Heart Association Scientific Session, 2013

A protective role of Fibroblast growth factor 23 against vascular calcification., American Heart Association Scientific Session, 2013

原因を特定しえなかった左側腹部痛に対し和漢診療が有効であった3症例, 第5回日本病院総合診療医学会学術総会（平成24年9月28日～29日）, 2012

転移性皮膚癌が疑われた2症例, 第5回日本病院総合診療医学会学術総会, 2012

Fibroblast Growth Factor23 Inhibits Osteogenic Differentiation Of Vascular Smooth Muscle Cells: A Protective Role Against Vasucular Calcification?, Annual Meeting of American Heart Association Scientific Sessions, 2012

Fibroblast Growth Factor23 Inhibits Osteogenic Differentiation Of Vascular Smooth Muscle Cells: A Protective Role Against Vasucular Calcification?, Annual Meeting of American Heart Association Scientific Sessions, 2012

CEA高値の原因を画像検査で特定しえなかった5症例の検討, 第3回日本病院総合診療医学会学術総会（平成23年9月9日～10日）（東京）, 2011

Competitive research funding

Molecular mechamisms of vascular smooth muscle cells in cardiovascular disease., Grant-in-Aid for Scientific Research, Competitive research funding

01 Apr. 2019, 31 Mar. 2023, 19K08508

The role of PIAS1/SUMO1 on pulmonary hypertension, Kowase Keiko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2015, 31 Mar. 2018, We have previously shown that the protein inhibitor of activated STAT (PIAS)1 promotes TGFb-induced activation of SMC gene expression at least in part by promoting sumoylaton. Here, we tested the hypothesis that PIAS1 and sumoylation promote pulmonary artery hypertension (PAH). An siRNA specific for PIAS1 and ubc9, an E2-ligase for sumoylation, inhibited TGFb- and Notch1-induced expression of SMC specific genes in cultured pulmonary artery smooth muscle cells (PASMC) as determined by real-time RT-PCR. Expression of osteoprotegerine (OPG) was also inhibited by siRNA specific for PIAS1 and ubc9. Moreover, overexpression of PIAS family and SRF increased OPG promoter activity. Immunohistochemistry of model mice for pulmonary hypertension revealed colocalized expression of TGFbRII, Notch1 and SMC markers in pulmonary artery, whereas SUMO1, OPG and ubc9 were expressed in tracheal epithelial cells. These results could indicate that sumoylation participated in PAH through OPG gene expression., 15K09152

The role of Notch1-TGFbeta-PIAS1 on pulmonary hypertension, KOWASE Keiko; KURABAYASHI Masahiko; NAKAHARA Takehiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2012, 31 Mar. 2015, We have previously shown that the protein inhibitor of activated STAT (PIAS)1 promotes TGFbeta-induced activation of SMC gene expression at least in part by promoting sumoylation. Here,we tested the hypothesis that Notch1-TGFbeta-PIAS1 axis promote pulmonary artery hypertension (PAH).An siRNA specific for PIAS1 and ubc9, an E2-ligase for sumoylation, inhibited TGFbeta- and Notch1-induced expression of SMC specific genes in cultured pulmonary artery smooth muscle cells (PASMC) as determined by real-time RT-PCR. Expression of osteoprotegerine（OPG）was also inhibited by siRNA specific for PIAS1 and ubc9. Moreover,overexpression of PIAS family increased OPG promoter activity. Immunohistochemistry of model mice for hypoxia-induced pulmonary hypertension revealed colocalized expression of TGFbetaRII、Notch1 and SMC marker in pulmonary artery, whereas SUMO1 and OPG were expressed in tracheal epithelial cell. These results could indicate that Notch1-TGFbeta-PIAS1 axis participate in PAH., 24591108