Researcher Profile and Settings

Researcher

• Name

  INOUE Yusuke

Affiliation

• Department of Materials and Bioscience, Professor

Profile and Settings

• Name

  Inoue, Yusuke

Foreign language

• Use in presentation

  English, English

• Use in publication

  English, English

Affiliation

• Gunma University, Associate Professor

Affiliation

• Affiliation

  Graduate School of Science and Technology

• Job title

  Professor

Degree

• 条件付

Association Memberships

• The Molecular Biology Society of Japan
• American Society for Microbiology
• American Society for Biochemistry and Molecular Biology

Research Activities

Research Areas

• Life sciences, Genetics
• Life sciences, Cell biology
• Life sciences, Molecular biology

Research Interests

• HNF4alpha
• C/EBPalpha
• PPARalpha
• liver
• knockout mice
• RNA
• nuclear receptor
• transcriptin factor
• diabetes
• metabolism

Published Papers

• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice, Kasano-Camones CI, Takizawa T, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y, 2022, J Biochem, 173, 5, 393, 411, Scientific journal
• Histidine-rich glycoprotein suppresses the S100A8/A9-mediated organ-tropic metastasis of melanoma cells, Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma IMW, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto KI, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M., 2022, Int J Mol Sci, 23, 18, 1030
• Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation, Rodrigoa AGH, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki S, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto K, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi, 2022, Biochem Biophys Res Commun, 634, 83, 91
• Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression, Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, et al, 2019, Mol Carcinogen., 58, 980, 995

  DOI
• Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue, Tomonobu N, Kinoshita R, Sumardika IW, Youyi C, Inoue Y, Yamauchi A, Yamamoto KI, Murata H, Sakaguchi M., 2019, Biochem Biophys Rep, 18, 100619

  DOI
• Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion, Chen Y, Sumardika IW, Tomonobu N, Ruma IMW, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, et al, 2019, Cancer Lett, 452, 178

  DOI
• Upregulation of mobility in pancreatic cancer cells by secreted S100A11 through activation of surrounding fibroblasts, Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, et al, 2019, Oncology Research, 27, 945, 956
• Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness, Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, et al, 2019, Neoplasia, 21, 627, 640

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• Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility, Bajkowska K, Sumardika IW, Tomonobu N, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Komalasari NLGY, Jiang F, Yamauchi A, Ruma IMW, Kasano-Camones CI, Inoue Y, Sakaguchi M, 2020, Biochem Biophys Res Commun, 530, 432, 439

  DOI
• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, May 2009, Nature genetics, 41, 5, 553, 62, Scientific journal

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• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, Sep. 2008, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151, Scientific journal

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• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,SunHee Yim,Gilles Lambert,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue, Jul. 2008, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920, Scientific journal

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• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4 alpha 2 gene, Y Inoue,M Miyazaki,T Tsuji,M Sakaguchi,K Fukaya,NH Huh,M Namba, Nov. 2001, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 8, 5, 481, 487, Scientific journal
• Loss of nuclear localization of the S100C protein in immorialized human fibroblasts, M Sakaguchi,H Yamada,T Tsuji,Y Inoue,M Miyazaki,T Tanaka,M Namba, Jan. 2001, RADIATION RESEARCH, 155, 1, 208, 214, Scientific journal

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• Hepatocyte nuclear factor 4alpha controls iron metabolism and regulates transferrin receptor 2 in mouse liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, Dec. 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865, Scientific journal

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• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, Sep. 2013, PLOS ONE, 8, 9, e74637, Scientific journal

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• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, Mar. 2013, ONCOLOGY REPORTS, 29, 3, 1073, 1079, Scientific journal

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• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, Nov. 2010, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273, Scientific journal

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• The role of hepatocyte nuclear factor 4 alpha in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, H. Safdar,Y. Inoue,G. H. van Puijvelde,P. H. Reitsma,B. J. M. van Vlijmen, Dec. 2010, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841

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• Hepatocyte nuclear factor-4 alpha is essential for glucosestimulated insulin secretion by pancreatic beta-cells, A Miura,K Yamagata,M Kakei,H Hatakeyama,N Takahashi,K Fukui,T Nammo,K Yoneda,Y Inoue,FM Sladek,MA Magnuson,H Kasai,J Miyagawa,FJ Gonzalez,Shimomura\, I, Feb. 2006, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257, Scientific journal

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• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha, Elyhisha A. Hanniman,Gilles Lambert,Yusuke Inoue,Frank J. Gonzalez,Christopher J. Sinal, Nov. 2006, JOURNAL OF LIPID RESEARCH, 47, 11, 2503, 2514, Scientific journal

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• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4 alpha and peroxisome proliferator-activated receptor alpha, Mariko Shin,Insook Kim,Yusuke Inoue,Shioko Kimura,Frank J. Gonzalez, Oct. 2006, MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290, Scientific journal

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• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4 alpha, Y Inoue,AM Yu,SH Yim,XC Ma,KW Krausz,J Inoue,CC Xiang,MJ Brownstein,G Eggertsen,Bjorkhem\, I,FJ Gonzalez, Jan. 2006, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227, Scientific journal

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• Role of hepatocyte nuclear factor 4 alpha in control of blood coagulation factor gene expression, Y Inoue,LL Peters,SH Yim,J Inoue,FJ Gonzalez, Apr. 2006, JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344, Scientific journal

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• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, Jan. 2006, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57, Scientific journal

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• Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 gene, H Pu,T Tsuji,A Kondo,K Fushimi,R Ohashi,Y Inoue,T Mimura,K Hamazaki,M Miyazaki,M Namba, Dec. 1997, ACTA MEDICA OKAYAMA, 51, 6, 313, 319, Scientific journal

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• Pyruvate alleviates toxic effects of ethanol on cells in culture, K Fukaya,M Miyazaki,H Pu,B Katayama,Y Inoue,R Ohashi,C Nakamura,M Namba, Sep. 1997, ARCHIVES OF TOXICOLOGY, 71, 10, 651, 654, Scientific journal

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• Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory, K Mihara,M Miyazaki,T Kondo,K Fushimi,T Tsuji,Y Inoue,K Fukaya,C Ishioka,M Namba, Oct. 1997, ACTA MEDICA OKAYAMA, 51, 5, 261, 265, Scientific journal

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• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, Jun. 2007, HEPATOLOGY, 45, 6, 1478, 1488, Scientific journal

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• 2-DIMENSIONAL ELECTROPHORETIC ANALYSIS OF DOWN-REGULATED PROTEINS IN HUMAN FIBROBLASTS IMMORTALIZED BY TREATMENT WITH EITHER 4-NITROQUINOLINE 1-OXIDE OR CO-60 GAMMA-RAYS, T KONDO,K MIHARA,Y INOUE,M IIJIMA,M NAMBA, Jun. 1995, ELECTROPHORESIS, 16, 6, 1067, 1073, Scientific journal

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• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha, O Barbier,H Girard,Y Inoue,H Duez,L Villeneuve,A Kamiya,JC Fruchart,C Guillemette,FJ Gonzalez,B Staels, Jan. 2005, MOLECULAR PHARMACOLOGY, 67, 1, 241, 249, Scientific journal

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• Maintenance of near-diploid karyotype of PA-1 human ovarian teratocarcinoma cells due to death of polyploid cells by chromosome fragmentation/pulverization, C Gao,M Miyazaki,R Ohashi,T Tsuji,Y Inoue,M Namba, Sep. 1999, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 4, 3, 291, 294, Scientific journal
• Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma, C Gao,R Ohashi,H Pu,Y Inoue,T Tsuji,M Miyazaki,M Namba, Nov. 1999, ONCOLOGY REPORTS, 6, 6, 1267, 1271, Scientific journal
• Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages, C Gao,M Miyazaki,JW Li,T Tsuji,Y Inoue,M Namba, Dec. 1999, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 4, 6, 597, 600, Scientific journal
• Enhanced activity of cyclin A-associated kinase in immortalized human fibroblasts, R Ohashi,M Miyazaki,K Fushimi,T Tsuji,Y Inoue,N Shimizu,M Namba, Aug. 1999, INTERNATIONAL JOURNAL OF CANCER, 82, 5, 754, 758, Scientific journal

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• Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4 alpha and C/EBP alpha, Huma Safdar,Ka Lei Cheung,Hans L. Vos,Frank J. Gonzalez,Pieter H. Reitsma,Yusuke Inoue,Bart J. M. van Vlijmen, Jun. 2012, PLOS ONE, 7, 6, Scientific journal

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• Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65, Hiroyuki Kogure,Yusuke Hikawa,Mamoru Hagihara,Naoya Tochio,Seizo Koshiba,Yusuke Inoue,Peter Guentert,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, Nov. 2012, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 80, 11, 2629, 2642, Scientific journal

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• C/EBP alpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism, B Courselaud,C Pigeon,Y Inoue,J Inoue,FJ Gonzalez,P Leroyer,D Gilot,K Boudjema,C Guguen-Guillouzo,P Brissott,O Loreal,G Ilyin, Oct. 2002, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 43, 41163, 41170, Scientific journal

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• Defective ureagenesis in mice carrying a liver-specific disruption of he-datocvte nuclear factor 4 alpha (HNF4 alpha) - HNF4 alpha regulates ornithine transcarbamylase in vivo, Y Inoue,GP Hayhurst,J Inoue,M Mori,FJ Gonzalez, Jul. 2002, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 28, 25257, 25265, Scientific journal

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• Role of the hepatocyte nuclear factor 4 alpha in control of the pregnane X receptor during fetal liver development, A Kamiya,Y Inoue,FJ Gonzalez, Jun. 2003, HEPATOLOGY, 37, 6, 1375, 1384, Scientific journal

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• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, Aug. 2003, GASTROENTEROLOGY, 125, 2, 544, 555, Scientific journal

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• Regulation of hepatic fasting response by PPAR gamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis, J Rhee,Y Inoue,JC Yoon,P Puigserver,ML Fan,FJ Gonzalez,BM Spiegelman, Apr. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017, Scientific journal

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• Serine/threonine phosphorylation regulates HNF-4 alpha-dependent redox-mediated iNOS expression in hepatocytes, HT Guo,JP Wei,Y Inoue,FJ Gonzalez,PC Kuo, Apr. 2003, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284, 4, C1090, C1099, Scientific journal

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• The orphan nuclear receptor HNF4 alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4, RG Tirona,W Lee,BF Leake,LB Lan,CB Cline,Lamba\, V,F Parviz,SA Duncan,Y Inoue,FJ Gonzalez,EG Schuetz,RB Kim, Feb. 2003, NATURE MEDICINE, 9, 2, 220, 224, Scientific journal

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• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, Apr. 2004, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862, Scientific journal

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• Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice, K Matsusue,O Gavrilova,G Lambert,HB Brewer,JM Ward,Y Inoue,D LeRoith,FJ Gonzalez, Nov. 2004, MOLECULAR ENDOCRINOLOGY, 18, 11, 2751, 2764, Scientific journal

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• Hepatocyte nuclear factors 1 alpha and 4 alpha control expression of proline oxidase in adult liver, A Kamiya,Y Inoue,T Kodama,FJ Gonzalez, Dec. 2004, FEBS LETTERS, 578, 1-2, 63, 68, Scientific journal

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• Hepatocyte nuclear factor 4 alpha is a central regulator of bile acid conjugation, Y Inoue,AM Yu,J Inoue,FJ Gonzalez, Jan. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489, Scientific journal

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• Disruption of hepatic C/EBP alpha results in impaired glucose tolerance and age-dependent hepatosteatosis, Y Inoue,J Inoue,G Lambert,SH Yim,FJ Gonzalez, Oct. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748, Scientific journal

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• ATP inhibition of proliferation of immortalized human fibroblasts is greater than that of normal human diploid fibroblasts, B Katayama,M Sakaguchi,JW Li,H Pu,Y Inoue,M Namba, Nov. 1998, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2, 5, 603, 606, Scientific journal
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, Dec. 2016, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

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• β-1,3-Galactosyl-O-Glycosyl-Glycoprotein β-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility., I Wayan Sumardika,Chen Youyi,Eisaku Kondo,Yusuke Inoue,I Made Winarsa Ruma,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Shuta Tomida,Kazuhiko Shien,Hiroki Sato,Akira Yamauchi,Junichiro Futami,Endy Widya Putranto,Toshihiko Hibino,Shinichi Toyooka,Masahiro Nishibori,Masakiyo Sakaguchi, 10 Apr. 2018, Oncology research, 26, 3, 431, 444

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• Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms., I Made Winarsa Ruma,Rie Kinoshita,Nahoko Tomonobu,Yusuke Inoue,Eisaku Kondo,Akira Yamauchi,Hiroki Sato,I Wayan Sumardika,Youyi Chen,Ken-Ichi Yamamoto,Hitoshi Murata,Shinichi Toyooka,Masahiro Nishibori,Masakiyo Sakaguchi, 23 Jul. 2018, Cancers, 10, 7, E239, E239

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• Ubiquitous presence of cellular proteins that specifically bind to the 3 ' terminal region of hepatitis C virus, Y Inoue,M Miyazaki,R Ohashi,T Tsuji,K Fukaya,H Kouchi,T Uemura,K Mihara,M Namba, Apr. 1998, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 245, 1, 198, 203, Scientific journal

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• Cyclin E overexpression responsible for growth of human hepatic tumors with p21(WAF1/CIP1/SDI1), T Tsuji,M Miyazaki,K Fushimi,K Mihara,Y Inoue,R Ohashi,M Ohtsubo,K Hamazaki,S Furusako,M Namba, Jan. 1998, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 242, 2, 317, 321, Scientific journal

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• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Hitoshi Murata,Masami Watanabe,Peng Huang,Rie Kinoshita,Junichiro Futami,Yusuke Inoue,Akira Yamauchi,I. Wayan Sumardika,Chen Youyi,Ken-Ichi Yamamoto,Yasutomo Nasu,Masahiro Nishibori,Toshihiko Hibino,Masakiyo Sakaguchi, Aug. 2016, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627, Scientific journal

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• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, Nov. 2016, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250, Scientific journal

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• Different expression of positive and negative regulators of hepatocyte growth in growing and shrinking hepatic lobes after portal vein branch ligation in rats, T Uemura,M Miyazaki,R Hirai,H Matsumoto,T Ota,R Ohashi,N Shimizu,T Tsuji,Y Inoue,M Namba, Feb. 2000, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 5, 2, 173, 179, Scientific journal
• Treatment of surgically induced acute liver failure with transplantation of highly differentiated immortalized human hepatocytes, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,H Noguchi,T Matsumura,T Watanabe,T Totsugawa,N Tanaka,M Namba, Sep. 2000, CELL TRANSPLANTATION, 9, 5, 733, 735, Scientific journal

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• Establishment of a highly differentiated immortalized human hepatocyte cell line as a source of hepatic function in the bioartificial liver, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,H Noguchi,N Tanaka,M Namba, Mar. 2000, TRANSPLANTATION PROCEEDINGS, 32, 2, 237, 241, Scientific journal

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• Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes, N Kobayashi,T Fujiwara,KA Westerman,Y Inoue,M Sakaguchi,H Noguchi,M Miyazaki,J Cai,N Tanaka,IJ Fox,P Leboulch, Feb. 2000, SCIENCE, 287, 5456, 1258, 1262, Scientific journal

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• Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro, SH Oh,M Miyazaki,H Kouchi,Y Inoue,M Sakaguchi,T Tsuji,N Shima,K Higashio,M Namba, Dec. 2000, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 279, 2, 500, 504, Scientific journal

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• A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines, T Tsuji,M Miyazaki,M Sakaguchi,Y Inoue,M Namba, Feb. 2000, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 268, 1, 20, 24, Scientific journal

  DOI
• Growth inhibitory effects of ATP and its derivatives on human fibroblasts immortalized with Co-60-gamma rays, JW Li,Y Inoue,M Miyazaki,H Pu,A Kondo,M Namba, Jan. 2000, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 5, 1, 59, 62, Scientific journal
• Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of P450 2E1-related cytotoxicity, Nozaki\, I,T Tsuji,M Sakaguchi,Y Inoue,R Hirai,A Andou,M Miyazaki,N Shimizu,M Namba, Oct. 2000, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 36, 9, 566, 570, Scientific journal

  DOI
• Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts, M Sakaguchi,M Miyazaki,Y Inoue,T Tsuji,H Kouchi,T Tanaka,H Yamada,M Namba, Jun. 2000, JOURNAL OF CELL BIOLOGY, 149, 6, 1193, 1206, Scientific journal

  DOI
• Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,T Uemura,H Noguchi,A Kondo,N Tanaka,M Namba, Jan. 2000, TRANSPLANTATION, 69, 2, 202, 207, Scientific journal

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, Jan. 2011, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717, Scientific journal

  DOI
• Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or Co-60 gamma rays, T Kondo,K Mihara,Y Inoue,M Namba, Oct. 1996, ELECTROPHORESIS, 17, 10, 1638, 1642, Scientific journal

  DOI
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Hiroto Fujita,Yusuke Inoue,Masayasu Kuwahara, Jan. 2018, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1, 35, 39, Scientific journal

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, Jul. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218, Scientific journal

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, Jul. 2014, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630, Scientific journal

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, Aug. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402, Scientific journal

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Aoi Morimoto,Mana Kannari,Yuichi Tsuchida,Shota Sasaki,Chinatsu Saito,Tsuyoshi Matsuta,Tsukasa Maeda,Megumi Akiyama,Takahiro Nakamura,Masakiyo Sakaguchi,Nobukazu Nameki,Frank J. Gonzalez,Yusuke Inoue, Jun. 2017, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585, Scientific journal

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137, Scientific journal

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, Jul. 2017, ONCOLOGY LETTERS, 14, 1, 1041, 1048, Scientific journal

  DOI
• Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells, Sasaki S,Hara A,Sakaguchi M,Nangaku M,Inoue Y, Nov. 2018, Biochemistry and Biophysics Reports, 17, none, 87, 92

  DOI
• Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers, Takamatsu H,Yamamoto KI,Tomonobu N,Murata H,Inoue Y,Yamauchi Y,Sumardika IW,Youyi C,Kinoshita R,Yamamura M,Fujiwara H,Mitsui Y,Araki K,Futami J,Saito K,Iioka H,Ruma IM,Putranto EW,Nishibori M,Kondo E,Yamamoto Y,Toyooka S,Sakaguchi M, Nov. 2018, Oncology Research, 27, 6, 713, 727, Scientific journal

  DOI
• Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis, Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Winarsa Ruma IM,Yamamoto H,Soh J,Hibino T,Nishibori M,Kondo E,Toyooka S,Sakaguchi M, Oct. 2018, International Journal of Cancer, 145, 2, 569, 575

  DOI
• Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4γ., Sasaki S,Urabe M,Maeda T,Suzuki J,Irie R,Suzuki M,Tomaru Y,Sakaguchi M,Gonzalez FJ,Inoue Y, Sep. 2018, Molecular and Cellular Biology, 38, 24, e00213-18, e00213-18

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi R,Gao C,Miyazaki M,Hamazaki K,Tsuji T,Inoue Y,Uemura T,Hirai R,Shimizu N,Namba M, 2001, Anticancer Research, 21, 657-662.
• The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory., Mihara K,Miyazaki M,Fushimi K,Tsuji T,Inoue Y,Fukaya K,Ohashi R,Namba M, 1997, Tissue Culture Research Communications, 16, 173, 178

  DOI
• Immortalization of cultured human fibroblasts with the mutant p53 gene and X-rays., Namba M,Mihara K,Kondo T,Inoue Y,Tsuji T,Fushimi K,Shima T,Iijima M, 1996, 3, 294, 298

  DOI
• Comparison of aging and immortalization process of cells derived from brains of newborn and old rats, Abe E,Yuasa T,Kondo T,Kondo Y,Tsuji T,Inoue Y,Fushimi K,Namba M, 1996, Tissue Culture Research Communications, 15, 179, 185

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Ahn, Sung-Hoon;Shah, Yatrik M.;Inoue, Junko;Morimura, Keiichirou;Kim, Insook;Yim, SunHee;Lambert, Gilles;Kurotani, Reiko;Nagashima, Kunio;Gonzalez, Frank J.;Inoue, Yusuke, 2008, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level, Tomonobu, Nahoko;Komalasari, Ni Luh Gede Yoni;Sumardika, I. Wayan;Jiang, Fan;Chen, Youyi;Yamamoto, Ken-ichi;Kinoshita, Rie;Murata, Hitoshi;Inoue, Yusuke;Sakaguchi, Masakiyo, 2020, CHEMICO-BIOLOGICAL INTERACTIONS, 324, none, 109085, 109085

  DOI
• Synergistic regulation of hepatic Fsp27b expression by HNF4 alpha and CREBH, Kasano-Camones, Carlos Ichiro;Takizawa, Masayuki;Iwasaki, Wakana;Sasaki, Shota;Hamada, Mume;Morimoto, Aoi;Sakaguchi, Masakiyo;Gonzalez, Frank J.;Inoue, Yusuke, 2020, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530, 2, 432, 439

  DOI
• exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis., Rie Kinoshita,Hiroki Sato,Akira Yamauchi,Yuta Takahashi,Yusuke Inoue,I Wayan Sumardika,Youyi Chen,Nahoko Tomonobu,Kota Araki,Kazuhiko Shien,Shuta Tomida,Hidejiro Torigoe,Kei Namba,Eisuke Kurihara,Yusuke Ogoshi,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,Hiromasa Yamamoto,Junichi Soh,Toshihiko Hibino,Masahiro Nishibori,Eisaku Kondo,Shinichi Toyooka,Masakiyo Sakaguchi, 15 Jun. 2019, International journal of cancer, 144, 12, 3138, 3145

  DOI
• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice, Kasano-Camones, Carlos Ichiro;Takizawa, Masayuki;Ohshima, Noriyasu;Saito, Chinatsu;Iwasaki, Wakana;Nakagawa, Yuko;Fujitani, Yoshio;Yoshida, Ryo;Saito, Yoshifumi;Izumi, Takashi;Terawaki, Shin-Ichi;Sakaguchi, Masakiyo;Gonzalez, Frank J.;Inoue, Yusuke, 2023, JOURNAL OF BIOCHEMISTRY, 173, 5, 393, 411

  DOI
• LOXL1 and LOXL4 are novel target genes of the Zn²⁺-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells, Hirabayashi, Daisuke;Yamamoto, Ken-ichi;Maruyama, Akihiro;Tomonobu, Nahoko;Kinoshita, Rie;Chen, Youyi;Komalasari, Ni Luh Gede Yoni;Murata, Hitoshi;Gohara, Yuma;Jiang, Fan;Zhou, Jin;Ruma, I. Made Winarsa;Sumardika, I. Wayan;Yamauchi, Akira;Kuribayashi, Futoshi;Toyooka, Shinichi;Inoue, Yusuke;Sakaguchi, Masakiyo, 2023, FRONTIERS IN ONCOLOGY, 13

  DOI
• Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2, Komalasari, Ni Luh Gede Yoni;Tomonobu, Nahoko;Kinoshita, Rie;Chen, Youyi;Sakaguchi, Yoshihiko;Gohara, Yuma;Jiang, Fan;Yamamoto, Ken-ich;Murata, Hitoshi;Ruma, I. Made Winarsa;Sumardika, I. Wayan;Zhou, Jin;Yamauchi, Akira;Kuribayashi, Futoshi;Inoue, Yusuke;Toyooka, Shinichi;Sakaguchi, Masakiyo, 2023, FRONTIERS IN ONCOLOGY, 13

  DOI

MISC

• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, May 2009, Nature genetics, 41, 5, 553, 62

  DOI
• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, May 2009, Nature genetics, 41, 5, 553, 62

  DOI
• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, Sep. 2008, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151

  DOI
• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, Sep. 2008, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,SunHee Yim,Gilles Lambert,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue, Jul. 2008, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,SunHee Yim,Gilles Lambert,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue, Jul. 2008, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Hepatocyte Nuclear Factor 4 alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, Dec. 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865

  DOI
• Hepatocyte Nuclear Factor 4 alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, Dec. 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865

  DOI
• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, Sep. 2013, PLOS ONE, 8, 9, e74637

  DOI
• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, Sep. 2013, PLOS ONE, 8, 9, e74637

  DOI
• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, Mar. 2013, ONCOLOGY REPORTS, 29, 3, 1073, 1079

  DOI
• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, Mar. 2013, ONCOLOGY REPORTS, 29, 3, 1073, 1079

  DOI
• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, Nov. 2010, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273

  DOI
• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, Nov. 2010, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273

  DOI
• The role of hepatocyte nuclear factor 4 alpha in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, H. Safdar,Y. Inoue,G. H. van Puijvelde,P. H. Reitsma,B. J. M. van Vlijmen, Dec. 2010, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841, Report scientific journal

  DOI
• The role of hepatocyte nuclear factor 4 alpha in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, H. Safdar,Y. Inoue,G. H. van Puijvelde,P. H. Reitsma,B. J. M. van Vlijmen, Dec. 2010, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841, Report scientific journal

  DOI
• Hepatocyte nuclear factor-4 alpha is essential for glucosestimulated insulin secretion by pancreatic beta-cells, A Miura,K Yamagata,M Kakei,H Hatakeyama,N Takahashi,K Fukui,T Nammo,K Yoneda,Y Inoue,FM Sladek,MA Magnuson,H Kasai,J Miyagawa,FJ Gonzalez,Shimomura\, I, Feb. 2006, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257

  DOI
• Hepatocyte nuclear factor-4 alpha is essential for glucosestimulated insulin secretion by pancreatic beta-cells, A Miura,K Yamagata,M Kakei,H Hatakeyama,N Takahashi,K Fukui,T Nammo,K Yoneda,Y Inoue,FM Sladek,MA Magnuson,H Kasai,J Miyagawa,FJ Gonzalez,Shimomura\, I, Feb. 2006, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257

  DOI
• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4 alpha and peroxisome proliferator-activated receptor alpha, Mariko Shin,Insook Kim,Yusuke Inoue,Shioko Kimura,Frank J. Gonzalez, Oct. 2006, MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290

  DOI
• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4 alpha and peroxisome proliferator-activated receptor alpha, Mariko Shin,Insook Kim,Yusuke Inoue,Shioko Kimura,Frank J. Gonzalez, Oct. 2006, MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290

  DOI
• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4 alpha, Y Inoue,AM Yu,SH Yim,XC Ma,KW Krausz,J Inoue,CC Xiang,MJ Brownstein,G Eggertsen,Bjorkhem\, I,FJ Gonzalez, Jan. 2006, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227

  DOI
• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4 alpha, Y Inoue,AM Yu,SH Yim,XC Ma,KW Krausz,J Inoue,CC Xiang,MJ Brownstein,G Eggertsen,Bjorkhem\, I,FJ Gonzalez, Jan. 2006, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227

  DOI
• Role of hepatocyte nuclear factor 4 alpha in control of blood coagulation factor gene expression, Y Inoue,LL Peters,SH Yim,J Inoue,FJ Gonzalez, Apr. 2006, JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344

  DOI
• Role of hepatocyte nuclear factor 4 alpha in control of blood coagulation factor gene expression, Y Inoue,LL Peters,SH Yim,J Inoue,FJ Gonzalez, Apr. 2006, JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344

  DOI
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, Jan. 2006, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57

  DOI
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, Jan. 2006, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57

  DOI
• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, Jun. 2007, HEPATOLOGY, 45, 6, 1478, 1488

  DOI
• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, Jun. 2007, HEPATOLOGY, 45, 6, 1478, 1488

  DOI
• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha, O Barbier,H Girard,Y Inoue,H Duez,L Villeneuve,A Kamiya,JC Fruchart,C Guillemette,FJ Gonzalez,B Staels, Jan. 2005, MOLECULAR PHARMACOLOGY, 67, 1, 241, 249

  DOI
• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha, O Barbier,H Girard,Y Inoue,H Duez,L Villeneuve,A Kamiya,JC Fruchart,C Guillemette,FJ Gonzalez,B Staels, Jan. 2005, MOLECULAR PHARMACOLOGY, 67, 1, 241, 249

  DOI
• Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4 alpha and C/EBP alpha, Huma Safdar,Ka Lei Cheung,Hans L. Vos,Frank J. Gonzalez,Pieter H. Reitsma,Yusuke Inoue,Bart J. M. van Vlijmen, Jun. 2012, PLOS ONE, 7, 6

  DOI
• Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4 alpha and C/EBP alpha, Huma Safdar,Ka Lei Cheung,Hans L. Vos,Frank J. Gonzalez,Pieter H. Reitsma,Yusuke Inoue,Bart J. M. van Vlijmen, Jun. 2012, PLOS ONE, 7, 6

  DOI
• Role of the hepatocyte nuclear factor 4 alpha in control of the pregnane X receptor during fetal liver development, A Kamiya,Y Inoue,FJ Gonzalez, Jun. 2003, HEPATOLOGY, 37, 6, 1375, 1384

  DOI
• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, Aug. 2003, GASTROENTEROLOGY, 125, 2, 544, 555

  DOI
• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, Aug. 2003, GASTROENTEROLOGY, 125, 2, 544, 555

  DOI
• Regulation of hepatic fasting response by PPAR gamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis, J Rhee,Y Inoue,JC Yoon,P Puigserver,ML Fan,FJ Gonzalez,BM Spiegelman, Apr. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017

  DOI
• Regulation of hepatic fasting response by PPAR gamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis, J Rhee,Y Inoue,JC Yoon,P Puigserver,ML Fan,FJ Gonzalez,BM Spiegelman, Apr. 2003, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017

  DOI
• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, Apr. 2004, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862

  DOI
• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, Apr. 2004, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862

  DOI
• Hepatocyte nuclear factors 1 alpha and 4 alpha control expression of proline oxidase in adult liver, A Kamiya,Y Inoue,T Kodama,FJ Gonzalez, Dec. 2004, FEBS LETTERS, 578, 1-2, 63, 68

  DOI
• Hepatocyte nuclear factor 4 alpha is a central regulator of bile acid conjugation, Y Inoue,AM Yu,J Inoue,FJ Gonzalez, Jan. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489

  DOI
• Hepatocyte nuclear factor 4 alpha is a central regulator of bile acid conjugation, Y Inoue,AM Yu,J Inoue,FJ Gonzalez, Jan. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489

  DOI
• Disruption of hepatic C/EBP alpha results in impaired glucose tolerance and age-dependent hepatosteatosis, Y Inoue,J Inoue,G Lambert,SH Yim,FJ Gonzalez, Oct. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748

  DOI
• Disruption of hepatic C/EBP alpha results in impaired glucose tolerance and age-dependent hepatosteatosis, Y Inoue,J Inoue,G Lambert,SH Yim,FJ Gonzalez, Oct. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748

  DOI
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, Dec. 2016, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

  DOI
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, Dec. 2016, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

  DOI
• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Hitoshi Murata,Masami Watanabe,Peng Huang,Rie Kinoshita,Junichiro Futami,Yusuke Inoue,Akira Yamauchi,I. Wayan Sumardika,Chen Youyi,Ken-Ichi Yamamoto,Yasutomo Nasu,Masahiro Nishibori,Toshihiko Hibino,Masakiyo Sakaguchi, Aug. 2016, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627

  DOI
• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Hitoshi Murata,Masami Watanabe,Peng Huang,Rie Kinoshita,Junichiro Futami,Yusuke Inoue,Akira Yamauchi,I. Wayan Sumardika,Chen Youyi,Ken-Ichi Yamamoto,Yasutomo Nasu,Masahiro Nishibori,Toshihiko Hibino,Masakiyo Sakaguchi, Aug. 2016, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627

  DOI
• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, Nov. 2016, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250

  DOI
• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, Nov. 2016, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, Jan. 2011, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, Jan. 2011, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717

  DOI
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Hiroto Fujita,Yusuke Inoue,Masayasu Kuwahara, Jan. 2018, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1, 35, 39

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, Jul. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, Jul. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, Jul. 2014, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, Jul. 2014, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, Aug. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, Aug. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Aoi Morimoto,Mana Kannari,Yuichi Tsuchida,Shota Sasaki,Chinatsu Saito,Tsuyoshi Matsuta,Tsukasa Maeda,Megumi Akiyama,Takahiro Nakamura,Masakiyo Sakaguchi,Nobukazu Nameki,Frank J. Gonzalez,Yusuke Inoue, Jun. 2017, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Aoi Morimoto,Mana Kannari,Yuichi Tsuchida,Shota Sasaki,Chinatsu Saito,Tsuyoshi Matsuta,Tsukasa Maeda,Megumi Akiyama,Takahiro Nakamura,Masakiyo Sakaguchi,Nobukazu Nameki,Frank J. Gonzalez,Yusuke Inoue, Jun. 2017, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, Jul. 2017, ONCOLOGY LETTERS, 14, 1, 1041, 1048

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, Jul. 2017, ONCOLOGY LETTERS, 14, 1, 1041, 1048

  DOI
• Hepatocyte nuclear factors 1α and 4α control expression of proline oxidase in adult liver., Kamiya\, A,Inoue\, Y,Kodama\, T,Gonzalez\, F. J, 2004, 578, 63, 68

  DOI
• The orphan nuclear receptor HNF4 determines PXR, CAR and FXR-mediated induction by xenobiotics., Tirona\, R. G,Lee\, W,Leake\, B. F,Lan\, L. B,Brimer\, C,Lamda\, V,Parviz\, F,Duncan\, S. A,Inoue\, Y,Gonzalez\, F. J,Schuetz\, E. G,Kim\, R. B, 2003, 9, 220-224.

  DOI
• Serine/threonine phosphorylation regulates HNF-4 dependent redox mediated iNOS expression in hepatocytes., Guo\, H. T,Wei\, J. P,Inoue\, Y,Gonzalez\, F. J,Kuo\, P. C, 2003, 284, C1090-1099.
• C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism; Cross-talk between C/EBP pathway and iron metabolism., Courselaud\, B,Pigeon\, C,Inoue\, Y,Inoue\, J,Gonzalez\, F. J,Leroyer\, P,Gilot\, D,Boudjema\, K,Guguen-Guillouzo\, C,Brissot\, P,Loreal\, O,Ilyin\, G, 2002, 277, 41163-41170.

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi\, R,Gao\, C,Miyazaki\, M,Hamazaki\, K,Tsuji\, T,Inoue\, Y,Uemura\, T,Hirai\, R,Shimizu\, N,Namba\, M, 2001, 21, 657-662.
• Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts., Sakaguchi\, M,Tsuji\, T,Inoue\, Y,Miyazaki\, M,Namba\, M,Yamada\, H,Tanaka\, T, 2001, 155, 208-214.

  DOI
• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4α2 gene., Inoue\, Y,Miyazaki\, M,Tsuji\, T,Sakaguchi\, M,Fukaya\, K,Huh\, N. H,Namba\, M, 2001, 84, 481-487.
• Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α); HNF4α regulates ornithine transcarbamylase in vivo., Inoue\, Y,Hayhurst\, G. P,Inoue\, J,Mori\, M,Gonzalez\, F. J, 2002, 277, 25257-25265.
• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 and PGC-1., Hanniman\, E. A,Lambert\, G,Inoue\, Y,Gonzalez\, F. J,Sinal\, C. J, 2006, 47, 215, 227

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• Ohashi, R., Miyazaki, M., Fushimi, K., Tsuji, T., Inoue, Y., Shimizu, N., and Namba, M. (1999) Enhanced activity of cyclin A-associated kinase in immortalized human fibroblasts., 井上 裕介, 1999, 82, 754-758.
• Mihara, K., Miyazaki, M., Fushimi, K., Tsuji, T., Inoue, Y., Fukaya, K., Ohashi, R., and Namba, M. (1997) The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory., 井上 裕介, 1997, 16, 173-178.
• Abe, E., Yuasa, T., Kondo, T., Kondo, Y., Tsuji, T., Inoue, Y., Fushimi, K., and Namba, M. (1996) Comparison of aging and immortalization process of cells derived from brains of newborn and old rats., 井上 裕介, 1996, 15, 179-185.
• Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., and Namba, M. (1999) Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma., 井上 裕介, 1999, 6, 1267-1271.
• Gao, C., Miyazaki, M., Ohashi, R., Tsuji, T., Inoue, Y., and Namba, M. (1999) Maintenance of near-diploid karyotype of PA-1 human ovarian teratocarcinoma cells due to death of polyploid cells by chromosome fragmentation/pulverization., 井上 裕介, 1999, 4, 291-294.
• Tsuji, T., Miyazaki, M., Fushimi, K., Mihara, K., Inoue, Y., Ohashi, R., Ohtsubo, M., Hamazaki, K., Furusako, S., and Namba, M. (1998) Cyclin E overexpression responsible for growth of human hepatic tumors with p21WAF1/CIP1/SDI1., 井上 裕介, 1998, 242, 317-321.
• Katayama, B., Sakaguchi, M., Li, W. J., Pu, H., Inoue, Y., and Namba, M. (1998) ATP inhibition of proliferation of immortalized human fibroblasts is greater than that of normal diploid fibroblasts., 井上 裕介, 1998, 2, 603-606.
• Li, J. W., Inoue, Y., Miyazaki, M., Pu, H., Kondo, A., and Namba, M. (2000) Growth inhibitory effects of ATP and its derivatives on human fibroblasts immortalized with 60Co-gamma rays., 井上 裕介, 2000, 5, 59-62.
• Kobayashi, N., Fujiwara, T., Westerman, K. A., Inoue, Y., Sakaguchi, M., Noguchi, H., Miyazaki, M., Cai, J., Tanaka, N., Fox, I. J., and Leboulch, P. (2000) Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes., 井上 裕介, 2000, 287, 1258-1262.
• Gao, C., Miyazaki, M., Li, J. W., Tsuji, T., Inoue, Y., and Namba, M. (1999) Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages., 井上 裕介, 1999, 4, 597-600.
• Fukaya, K., Miyazaki, M., Pu, H., Katayama, B., Inoue, Y., Ohashi, R., Nakamura, C., and Namba, M. (1997) Pyruvate alleviates toxic effects of ethanol on cells in culture., 井上 裕介, 1997, 71, 651-654.
• Mihara, K., Miyazaki, M., Kondo, T., Fushimi, K., Tsuji, T., Inoue, Y., Fukaya, K., Ishioka, C., and Namba, M. (1997) Yeast functional assay of the p53 gene status in human cell lines maintain in our laboratory., 井上 裕介, 1997, 51, 261-265.
• Pu, H., Tsuji, T., Kondo, A., Fushimi, K., Ohashi, R., Inoue, Y., Mimura, T., Hamazaki, K., Miyazaki M, Namba M (1997) Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 genes., 井上 裕介, 1997, 51, 313-319.
• Kondo, T., Mihara, K., Inoue, Y., and Namba, M. (1996) Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline1-oxide or 60Co gamma rays., 井上 裕介, 1996, 17, 1638-1642.
• Namba, M., Mihara, K., Kondo, T., Inoue, Y., Tsuji, T., Fushimi, K., Shima, T., and Iijima, M. (1996) Immortalization of cultured human fibroblasts with the mutant p53 gene and X-rays., 井上 裕介, 1996, 3,?294-298.
• Kondo, T., Mihara, K., Inoue, Y., Iijima, M., and Namba, M. (1995) Two-dimensional electrophoretic analysis of down-regulated proteins in human fibroblasts immortalized by treatment with either 4-nitroquinoline1-oxide or 60Co gamma rays., 井上 裕介, 1996, 16, 1067-1073.
• Uemura, T., Miyazaki, M., Hirai, R., Matsumoto, H., Ota, T., Ohashi, R., Shimizu, N., Tsuji, T., Inoue, Y., and Namba, M. (2000) Different expression of positive and negative regulators of hepatocyte growth in growing and shrinking hepatic lobes after ・・・, 井上 裕介, 2000, 5, 173-179.
• Nozaki, I., Tsuji, T., Sakaguchi, M., Inoue, Y., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., and Namba, M. (2000) Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of P450 2E1-related cytotoxicity., 井上 裕介, 2000, 36, 566-570.

  DOI
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Noguchi, H., Matsumura, T., Watanabe, T., Totsugawa, T., Tanaka, N., and Namba, M. (2000) Treatment of surgically induced acute liver failure with transplantation of highly differentiat・・・, 井上 裕介, 2000, 9, 733-735.
• Sakaguchi, M., Miyazaki, M., Inoue, Y., Tsuji, T., Kouchi, H., Tanaka, T., Yamada, H., and Namba, M. (2000) Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts., 井上 裕介, 2000, 149, 1193-1206.

  DOI
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Uemura, T., Noguchi, H., Kondo, A., Tanaka, N., and Namba, M. (2000) Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure., 井上 裕介, 2000, 69, 202-207.
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Noguchi, H., Tanaka, N., and Namba M (2000) Establishment of a highly differentiated immortalized human hepatocyte cell line as a source of hepatic function in the bioartificial liver., 井上 裕介, 2000, 32, 237-241.
• Tsuji, T., Miyazaki, M., Sakaguchi, M., Inoue, Y., and Namba, M. (2000) A REIC gene shows down-regulation in human immortalized cells and humantumor-derived cell lines., 井上 裕介, 2000, 268, 20-24.
• Inoue, Y., Miyazaki, M., Ohashi, R., Tsuji, T., Fukaya, K., Kouchi, H., Uemura, T., Mihara, K., and Namba, M. (1998) Ubiquitous presence of cellular proteins that specifically bind to the 3' terminal region of hepatitis C virus., 井上 裕介, 1998, 245, 198-203.
• Oh, S. H., Miyazaki, M., Kouchi, H., Inoue, Y., Sakaguchi, M., Tsuji, T., Shima, N., Higashio, K., and Namba, M. (2000) Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. ・・・, 井上 裕介, 2000, 279, 500-504.
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Fujita\, Hiroto,Inoue\, Yusuke,Kuwahara\, Masayasu, 2018, 28, 1, 35, 39

  DOI
• Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development., Kamiya\, A,Inoue\, Y,Gonzalez\, F. J, 2003, Hepatology, 37, 1375-1384.

  DOI
• The orphan nuclear receptor HNF4 determines PXR, CAR and FXR-mediated induction by xenobiotics., Tirona\, R. G,Lee\, W,Leake\, B. F,Lan\, L. B,Brimer\, C,Lamda\, V,Parviz\, F,Duncan\, S. A,Inoue\, Y,Gonzalez\, F. J,Schuetz\, E. G,Kim\, R. B, 2003, Nat. Med., 9, 220-224.

  DOI
• Serine/threonine phosphorylation regulates HNF-4 dependent redox mediated iNOS expression in hepatocytes., Guo\, H. T,Wei\, J. P,Inoue\, Y,Gonzalez\, F. J,Kuo\, P. C, 2003, Am. J. Physiol. Cell Physiol., 284, C1090-1099.
• C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism; Cross-talk between C/EBP pathway and iron metabolism., Courselaud\, B,Pigeon\, C,Inoue\, Y,Inoue\, J,Gonzalez\, F. J,Leroyer\, P,Gilot\, D,Boudjema\, K,Guguen-Guillouzo\, C,Brissot\, P,Loreal\, O,Ilyin\, G, 2002, J. Biol. Chem., 277, 41163-41170.

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi\, R,Gao\, C,Miyazaki\, M,Hamazaki\, K,Tsuji\, T,Inoue\, Y,Uemura\, T,Hirai\, R,Shimizu\, N,Namba\, M, 2001, Anticancer Res., 21, 657-662.
• Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts., Sakaguchi\, M,Tsuji\, T,Inoue\, Y,Miyazaki\, M,Namba\, M,Yamada\, H,Tanaka\, T, 2001, Radiat. Res., 155, 208-214.

  DOI
• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4α2 gene., Inoue\, Y,Miyazaki\, M,Tsuji\, T,Sakaguchi\, M,Fukaya\, K,Huh\, N. H,Namba\, M, 2001, Int. J. Mol. Med., 84, 481-487.
• Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α); HNF4α regulates ornithine transcarbamylase in vivo., Inoue\, Y,Hayhurst\, G. P,Inoue\, J,Mori\, M,Gonzalez\, F. J, 2002, J. Biol. Chem., 277, 25257-25265.
• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 and PGC-1., Hanniman\, E. A,Lambert\, G,Inoue\, Y,Gonzalez\, F. J,Sinal\, C. J, 2006, J. Lipid Res., 47, 215, 227

  DOI

Presentations

• Maintenance of hepatic function by nuclear receptor HNF4α, Mini-symposium “Cellular sensing and maintenance, Inoue Y, Mini-symposium of Cellular sensing and maintenance, 2018, English, International conference
• 肝臓特異的HNF4α欠損マウスで発現上昇する転写因子の機能解析, 安藤翔太朗, 井上裕介, 第41回日本分子生物学会, 2018, Domestic conference
• 肝臓HNF4αの標的タンパク質の同定, 生井美帆, 井上 裕介, 第41回日本分子生物学会, 2018, Domestic conference
• PPARαカスケードの活性化による新規NASH発症機構の解明, 笠野一郎, 瀧澤将行, 齊藤千夏, Frank J. Gonzalez,井上裕介, 第41回日本分子生物学会, 2018, Domestic conference
• 新規HNF4γバリアントによる肝機能の誘導, 佐々木翔太, 浦部瑞穂, 前田つかさ, 鈴木淳子, 入江亮太, 阪口政清, Frank J. Gonzalez, 井上裕介, 第41回日本分子生物学会, 2018, Domestic conference
• HNF4AとCREBHによる肝臓CIDEC2/Fsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩﨑若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank J. Gonzalez、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020, Domestic conference
• 肝がん細胞を抑制するSALL1の標的遺伝子の同定, 齋藤義文、安藤翔太朗、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020, Domestic conference
• miR-455を介した新規HNF4αカスケードの同定, 加藤佑弥、小菅優里、秋山萌、岩﨑若菜、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020, Domestic conference
• ヒト肺がん細胞で発現する核内受容体HNF4αの 機能解析, 黒田知紘、亀井めぐみ、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020, Domestic conference
• 肝臓におけるHNF4α/miR-194-5p経路の標的遺伝子の探索, 岩崎若菜、守本葵、松田龍太郎、井上裕介, 第43回日本分子生物学会年会, 2020, Domestic conference
• HNF4αとCREBHによる肝臓のFsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩崎若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank Gonzalez、井上裕介, 第43回日本分子生物学会年会, 2020, Domestic conference
• 近位尿細管におけるHNF4αの標的遺伝子の同定, 淀美穂里、服部詩萌里、水野叶梧、柳田素子、井上裕介, 第43回日本分子生物学会年会, 2020, Domestic conference
• HNF4γ2に相互作用するタンパク質の探索, 江原伸哉、佐々木翔太、浦部 瑞穂、前田つかさ、鈴木淳子、入江亮太、鈴木正則、外丸靖浩、阪口政清、Gonzalez Frank、井上裕介, 第43回日本分子生物学会年会, 2020, Domestic conference
• 肝臓におけるHNF4α/miR-194経路の標的遺伝子の探索, 岩﨑若菜、守本葵、井上裕介, 第19回生体機能研究会, 2020, Domestic conference
• HNF4AとCREBHによる肝臓CIDE2/Fsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩﨑若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank J Gonzalez、井上裕介, 第19回生体機能研究会, 2020, Domestic conference
• 肝臓におけるHNF4α/miR-194-5p経路の標的遺伝子の探索, 岩崎若菜、守本葵、松田龍太郎、井上裕介, 第43回日本分子生物学会年会, Domestic conference
• 肺腺がん細胞における核内受容体HNF4αの機能解析と標的遺伝子の同定, 亀井めぐみ、濱田真輝、阪口政清、井上裕介, 第42回日本分子生物学会, 2019, Domestic conference
• miR-Xを介した肝臓の新規HNF4αカスケードの同定, 小菅優里、秋山萌、岩﨑若菜、井上裕介, 第42回日本分子生物学会, 2019, Domestic conference
• HNF4αを介した補体遺伝子C8γおよびC9の転写活性化機構の解析, 笠野一郎、大橋真衣子、横田聡美、坂本憲昭、Frank J. Gonzalez、井上裕介, 第42回日本分子生物学会, 2019, Domestic conference
• 肝臓特異的HNF4α欠損マウスにおけるHNF4γの機能解析, 第36回日本分子生物学会, 2013
• PPARαカスケードの活性化は肝臓特異的HNF4α欠損マウスで脂肪肝を発症する, 第36回日本分子生物学会, 2013
• 肝臓特異的HNF4α欠損マウスの血糖値低下機構の解明, 第36回日本分子生物学会, 2013
• HNF4αによるmiR-194/192の発現制御機構の解析と標的遺伝子の同定, 第36回日本分子生物学会, 2013
• 2型トランスフェリン受容体遺伝子の転写活性化機構の解析, 第36回日本分子生物学会, 2013
• ミトコンドリアにおける翻訳停滞解消因子ICT1およびC12orf65の機能解析, 第15回日本RNA学会, 2013
• PPARαカスケードの活性化による脂肪肝の発症, 第37回日本分子生物学会, 2014
• miR-194/192を介した新規HNF4αネットワークの解明, 第37回日本分子生物学会, 2014
• 肝臓特異的HNF4α欠損マウスにおけるHNF4γの機能解析, 第37回日本分子生物学会, 2014
• miR-194/192を介した新規HNF4αネットワークの解明, 第16回日本RNA学会, 2014
• Invastigation of a novel HNF4α network through miR-194/192., 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Enginering., 2014
• Investigation of hepatic HNF4γ., International symposium on homeostasis through development, life and diseases., 2014
• HNF4γの機能解析, 第38回日本生化学関東支部例会, 2015
• Hepatic HNF4α cascade through modulation of miR-194/192., 2nd International Symposium of Gunma University Medical Innovation., 2015
• HNF4γの転写活性化能の解析と相互作用タンパク質の探索, 第38回日本分子生物学会, 2015
• HNF4αはmiR-194/192を介して肝細胞の脱分化を抑制する, 第38回日本分子生物学会, 2015
• HNF4αによる補体遺伝子C8γの転写活性化機構の解析, 第36回日本分子生物学会, 2013
• HNF4αによるmiR-194/192の発現制御機構の解析と標的遺伝子の同定, 第15回日本RNA学会, 2013
• HNF4αによる肺がん形成、進行への影響, 第39回日本分子生物学会, 2016
• 肝臓特異的HNF4α欠損マウスの血糖値低下機構の解析, 第39回日本分子生物学会, 2016
• PPARαカスケードの活性化による脂肪肝の発症, 第39回日本分子生物学会, 2016
• Positive regulation of hepatic miRNA by HNF4α, 3rd international symposium of GUMI&AMDE 2016, 2016
• Invastigation of a novel HNF4α network through miR-194/192., 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Enginering., 2014
• Investigation of hepatic HNF4γ., International symposium on homeostasis through development, life and diseases., 2014
• Hepatic HNF4α cascade through modulation of miR-194/192., 2nd International Symposium of Gunma University Medical Innovation., 2015
• Positive regulation of hepatic miRNA by HNF4α, 3rd international symposium of GUMI&AMDE 2016, 2016

Industrial Property Rights

• Patent right, 特願2018-087576, 27 Apr. 2018, Yes, Yes

Awards

• 2003
• 2005
• 2016
• The Fellows Award For Research Excellence 2003, 2003
• The Fellows Award For Research Excellence 2005, 2005

Research Projects

• 2020, Competitive research funding, No international co-authorship
• 2019, Principal investigator, Competitive research funding, No international co-authorship
• 2005, 2006, Principal investigator, Competitive research funding
• 2009, 2010, Principal investigator, Competitive research funding
• 2005, 2006, Principal investigator, Competitive research funding
• 2010, 2011, Principal investigator, Competitive research funding
• 2013, 2016, Principal investigator, Competitive research funding
• 2017, 2018, Principal investigator, Competitive research funding
• 2010, 2012, Principal investigator, Competitive research funding
• 2016, 2019, Principal investigator, Competitive research funding

Social Contribution

Social Contribution

• 博士学生の米国派遣, 2022, 9999
• 食品科学特論, 17 Nov. 2023, 17 Nov. 2023
• 出張模擬授業（渋川高校）, 17 Nov. 2023, 17 Nov. 2023　(Target:　High school students)
• 食品科学特論の運営, 12 Nov. 2021, 19 Nov. 2021, Others　(Target:　College students, Graduate students, Teachers, Researchers, General, Company, Civic organization, Governmental agency)
• 出前授業（佐野東高校）, 18 Jun. 2021, 18 Jun. 2021, Visiting lecture　(Target:　High school students, Teachers)