Researcher Profile and Settings

Researcher

• Name

  SUGIYAMA Yuta

Profile and Settings

• Name

  Sugiyama, Yuta

Affiliation

• Gunma University, Center for Food Science and Wellness

Education

• Mar. 2020, Mar. 2020, Kyoto University, Graduate School of Agriculture
• Apr. 2010, Mar. 2012, Fukui Prefectural University
• Apr. 2006, Mar. 2010, Fukui Prefectural University, Faculty of Biotechnology, Department of Bioscience

Degree

• Ph.D.(Agriculture)

Association Memberships

• The Intestinal Microbiology Society, 2021, 9999
• Japan Society for Lactic Acid Bacteria, 2021, 9999
• The Japanese Society of Polyamine Research, 2015, 9999
• Japanese society for Food Factors, 2010, 9999
• Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2010, 9999

Research Experience

• Apr. 2021, 9999, Gunma University, Center for Food Science and Wellness, Assistant prof lv
• Apr. 2020, Mar. 2021, Kyoto University, Graduate School of Agriculture Division of Applied Life Sciences, Researcher postdoc lv
• Apr. 2018, Mar. 2020, Kyoto University, Graduate School of Agriculture Division of Applied Life Sciences, Research assistance
• Dec. 2013, Mar. 2018, Ishikawa Prefectural University, Host-Microbe Interaction Research Lab., Researcher postdoc lv
• Apr. 2012, Nov. 2013, Others

Research Activities

Research Areas

• Life sciences, Food sciences
• Life sciences, Applied biochemistry
• Life sciences, Applied microbiology

Research Interests

• Gut bacteria

Published Papers

• Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production, Sugiyama, Yuta;Mori, Yumiko;Nara, Misaki;Kotani, Yusuke;Nagai, Emiko;Kawada, Hiroki;Kitamura, Mayu;Hirano, Rika;Shimokawa, Hiromi;Nakagawa, Akira;Minami, Hiromichi;Gotoh, Aina;Sakanaka, Mikiyasu;Iida, Noriho;Koyanagi, Takashi;Katayama, Takane;Okamoto, Shigefumi;Kurihara, Shin, Oct. 2022, GUT MICROBES, 14, 1, Scientific journal

  DOI
• Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils, Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Shintaro Takeda, Tokiko Tabata, Masakazu Shinohara, Shigenobu Kishino, Yuta Sugiyama, Nahoko Kitamura, Hiroyuki Yamamoto, Tomofumi Takaya, Jun Ogawa, Ken-ichi Hirata, Oct. 2022, Atherosclerosis, 358, 1, 11

  DOI
• Effect of Grapevine Rootstocks on Anthocyanin Biosynthesis, Sugar Contents, and Endogenous Hormone Contents During the Berry Maturation of ‘Ruby Roman’, Mei Gao-Takai, Zen Lin, Yuta Sugiyama, Takane Katayama, Ai Shinmura, Hikaru Naito, Ayako Katayama-Ikegami, Oct. 2022, The Horticulture Journal, 91, 4, 476, 488, Scientific journal

  DOI
• Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota, Kyosuke Yakabe, Seiichiro Higashi, Masahiro Akiyama, Hiroshi Mori, Takumi Murakami, Atsushi Toyoda, Yuta Sugiyama, Shigenobu Kishino, Kenji Okano, Akiyoshi Hirayama, Aina Gotoh, Shunyi Li, Takeshi Mori, Takane Katayama, Jun Ogawa, Shinji Fukuda, Koji Hase, Yun-Gi Kim, Sep. 2022, Cell Reports, 40, 44, 111332, 111332, Scientific journal

  DOI
• Difference Between Coloration and Endogenous Abscisic Acid Accumulation Patterns in Two Red Grape Cultivars, ‘Aki Queen’ and ‘Ruby Roman’ (Vitis labruscana Bailey) Berries, Katayama-Ikegami, Ayako;Sugiyama, Yuta;Katayama, Takane;Sakamoto, Akiko;Shimada, Ryo;Miyazaki, Chiho;Gao-Takai, Mei, Jul. 2022, The Horticulture Journal, 91, 3, 312, 321, Scientific journal

  DOI
• Putrescine Production by Latilactobacillus curvatus KP 3-4 Isolated from Fermented Foods, Rika Hirano; Aiko Kume; Chisato Nishiyama; Ryosuke Honda; Hideto Shirasawa; Yiwei Ling; Yuta Sugiyama; Misaki Nara; Hiromi Shimokawa; Hiroki Kawada; Takashi Koyanagi; Hisashi Ashida; Shujiro Okuda; Mitsuharu Matsumoto; Hiroki Takagi; Shin Kurihara, 24 Mar. 2022, Microorganisms, 10, 4, 697, 697, Scientific journal

  DOI
• A possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases, Naofumi Yoshida; Tomoya Yamashita; Shigenobu Kishino; Hikaru Watanabe; Kengo Sasaki; Daisuke Sasaki; Tokiko Tabata; Yuta Sugiyama; Nahoko Kitamura; Yoshihiro Saito; Takuo Emoto; Tomohiro Hayashi; Tomoya Takahashi; Masakazu Shinohara; Ro Osawa; Akihiko Kondo; Takuji Yamada; Jun Ogawa; Ken-ichi Hirata, Dec. 2020, Scientific Reports, 10, 1, 13009, 13009, Scientific journal

  DOI
• Development of a new chromogenic method for putrescine quantification using coupling reactions involving putrescine oxidase, Yuta Sugiyama; Hirokazu Ohta; Rika Hirano; Hiromi Shimokawa; Mikiyasu Sakanaka; Takashi Koyanagi; Shin Kurihara, Mar. 2020, Analytical Biochemistry, 593, 113607, 113607, Scientific journal

  DOI
• Measuring the Antimicrobial Activity of Lauric Acid against Various Bacteria in Human Gut Microbiota Using a New Method, Miki Matsue; Yumiko Mori; Satoshi Nagase; Yuta Sugiyama; Rika Hirano; Kazuhiro Ogai; Kohei Ogura; Shin Kurihara; Shigefumi Okamoto, Dec. 2019, Cell Transplantation, 28, 12, 1528, 1541, Scientific journal

  DOI
• Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis, Mikiyasu Sakanaka; Morten Ejby Hansen; Aina Gotoh; Toshihiko Katoh; Keisuke Yoshida; Toshitaka Odamaki; Hiroyuki Yachi; Yuta Sugiyama; Shin Kurihara; Junko Hirose; Tadasu Urashima; Jin-zhong Xiao; Motomitsu Kitaoka; Satoru Fukiya; Atsushi Yokota; Leila Lo Leggio; Maher Abou Hachem; Takane Katayama, Aug. 2019, Science Advances, 5, 8, eaaw7696, eaaw7696, Scientific journal

  DOI
• Analysis of polyamine biosynthetic- and transport ability of human indigenous Bifidobacterium, Yuta Sugiyama; Misaki Nara; Mikiyasu Sakanaka; Aya Kitakata; Shujiro Okuda; Shin Kurihara, 02 Sep. 2018, Bioscience, Biotechnology, and Biochemistry, 82, 9, 1606, 1614, Scientific journal

  DOI
• Functional analysis of arginine decarboxylase gene speA of Bacteroides dorei by markerless gene deletion, Mikiyasu Sakanaka; Yuta Sugiyama; Misaki Nara; Aya Kitakata; Shin Kurihara, 01 Feb. 2018, FEMS Microbiology Letters, 365, 4, Scientific journal

  DOI
• Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes, Yuta Sugiyama; Misaki Nara; Mikiyasu Sakanaka; Aina Gotoh; Aya Kitakata; Shujiro Okuda; Shin Kurihara, Dec. 2017, The International Journal of Biochemistry & Cell Biology, 93, 52, 61, Scientific journal

  DOI
• Use of Gifu Anaerobic Medium for culturing 32 dominant species of human gut microbes and its evaluation based on short-chain fatty acids fermentation profiles, Aina Gotoh; Misaki Nara; Yuta Sugiyama; Mikiyasu Sakanaka; Hiroyuki Yachi; Aya Kitakata; Akira Nakagawa; Hiromichi Minami; Shujiro Okuda; Toshihiko Katoh; Takane Katayama; Shin Kurihara, 03 Oct. 2017, Bioscience, Biotechnology, and Biochemistry, 81, 10, 2009, 2017, Scientific journal

  DOI
• Application study of 1,2-α-l-fucosynthase: introduction of Fucα1-2Gal disaccharide structures on N-glycan, ganglioside, and xyloglucan oligosaccharide, Yuta Sugiyama; Toshihiko Katoh; Yuji Honda; Aina Gotoh; Hisashi Ashida; Shin Kurihara; Kenji Yamamoto; Takane Katayama, 01 Feb. 2017, Bioscience, Biotechnology, and Biochemistry, 81, 2, 283, 291, Scientific journal

  DOI
• A Novel Putrescine Exporter SapBCDF of Escherichia coli, Yuta Sugiyama; Atsuo Nakamura; Mitsuharu Matsumoto; Ayaka Kanbe; Mikiyasu Sakanaka; Kyohei Higashi; Kazuei Igarashi; Takane Katayama; Hideyuki Suzuki; Shin Kurihara, Dec. 2016, Journal of Biological Chemistry, 291, 51, 26343, 26351, Scientific journal

  DOI
• Carboxyspermidine decarboxylase of the prominent intestinal microbiota species Bacteroides thetaiotaomicron is required for spermidine biosynthesis and contributes to normal growth, Mikiyasu Sakanaka; Yuta Sugiyama; Aya Kitakata; Takane Katayama; Shin Kurihara, Oct. 2016, Amino Acids, 48, 10, 2443, 2451, Scientific journal

  DOI
• Introduction of H-antigens into oligosaccharides and sugar chains of glycoproteins using highly efficient 1,2-α-l-fucosynthase, Yuta Sugiyama; Aina Gotoh; Toshihiko Katoh; Yuji Honda; Erina Yoshida; Shin Kurihara; Hisashi Ashida; Hidehiko Kumagai; Kenji Yamamoto; Motomitsu Kitaoka; Takane Katayama, 22 Aug. 2016, Glycobiology, 26, 11, 1235, 1247, Scientific journal

  DOI
• Novel substrate specificities of two lacto-N-biosidases towards β-linked galacto-N-biose-containing oligosaccharides of globo H, Gb5, and GA1, Aina Gotoh; Toshihiko Katoh; Yuta Sugiyama; Shin Kurihara; Yuji Honda; Haruko Sakurama; Taiho Kambe; Hisashi Ashida; Motomitsu Kitaoka; Kenji Yamamoto; Takane Katayama, May 2015, Carbohydrate Research, 408, 18, 24, Scientific journal

  DOI
• Flavonols enhanced production of anti-inflammatory substance(s) byBifidobacterium adolescentis: Prebiotic actions of galangin, quercetin, and fisetin, Kyuichi Kawabata; Yuta Sugiyama; Taiken Sakano; Hajime Ohigashi, Jul. 2013, BioFactors, 39, 4, 422, 429, Scientific journal

  DOI
• 1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a Superoxide Generation Inhibitor fromPerilla frutescensvar.crispa, Masakazu TAKAHASHI; Yuta SUGIYAMA; Kyuichi KAWABATA; Yu TAKAHASHI; Kazuhiro IRIE; Akira MURAKAMI; Yoshito KUBO; Kyoichi KOBAYASHI; Hajime OHIGASHI, 23 Nov. 2011, Bioscience, Biotechnology, and Biochemistry, 75, 11, 2240, 2242, Scientific journal

  DOI
• N-Carbamoylputrescine Amidohydrolase of Bacteroides thetaiotaomicron, a Dominant Species of the Human Gut Microbiota, Shimokawa, Hiromi;Sakanaka, Mikiyasu;Fujisawa, Yuki;Ohta, Hirokazu;Sugiyama, Yuta;Kurihara, Shin, 2023, BIOMEDICINES, 11, 4

  DOI
• Segatella copri JCM 13464Tの大麦β-グルカン代謝遺伝子群の同定, ;;;;;;;, Jun. 2024, 35, 2, 156

MISC

• ヒト腸内常在細菌の芳香族アミン産生と宿主末梢セロトニンへの寄与, 杉山友太、栗原新, Jun. 2023, 7, 2, 102, 106
• 腸内細菌由来フェネチルアミンによる宿主セロトニン産生の促進, 杉山友太、栗原新, Jul. 2023, 81, 4, 305, 307
• ヒト腸内優勢菌バクテロイデス属細菌の類稀なるオリゴ糖資化能, 杉山友太, Aug. 2021, 99, 8, 438, 438, Introduction scientific journal
• Identification of the putrescine exporter PstSCAB of Proteus mirabilis, 平野里佳; 太田宏一; 杉山友太; 紺谷優季; 阪中幹祥; 栗原新, 2021, 日本農芸化学会大会講演要旨集(Web), 2021
• Mucin O-glycan assimilation pathway in Bifidobacterium, CHOI Moonhak; 後藤愛那; 阪中幹祥; 加藤紀彦; 西本完; 杉山友太; 栗原新; 吹谷智; 横田篤; 北岡本光; 片山高嶺, 2021, 日本農芸化学会大会講演要旨集(Web), 2021
• A new measuring method for antimicrobial activity of lauric acid against various human gut microbes, 松榮 美希; 森 裕美子; 長瀬 賢史; 小倉 康平; 大貝 和裕; 杉山 友太; 平野 里佳; 栗原 新; 岡本 成史, Jan. 2020, 75, 1, 103, 103
• Versatility evaluation of 1,2-α-L-fucosynthase, 杉山友太; 片山高嶺; 栗原新, 2019, IFO RESEARCH COMMUNICATIONS, 33, 153, 161
• Generation of a highly efficient 1,2-α-L-fucosynthase and its use for introducing H-antigen structure into various glycoconjugates, 杉山友太; 片山高嶺; 栗原新, 2019, IFO RESEARCH COMMUNICATIONS, 33, 139, 152
• Identification of SapBCDF as a novel putrescine exporter of Escherichia coli, 杉山友太; 阪中幹祥; 片山 高嶺; 栗原 新, 2019, IFO RESEARCH COMMUNICATIONS, 33, 91, 103
• Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes., 杉山友太; 阪中幹祥; 栗原新, 2019, IFO RESEARCH COMMUNICATIONS, 33, 79, 90
• Analysis of polyamine biosynthetic- and transport ability of human indigenous Bifidobacteria., 杉山友太; 栗原新, Nov. 2018, Polyamine, 5, 2, 52, 52
• ABCトランスポーターを介したビフィズス菌の糖質取込みを包括的に制御するATP加水分解酵素MsiK, 阪中幹祥; 前田信悟; 後藤愛那; 村上隆太; 加藤紀彦; 杉山友太; 谷内寛之; 栗原新; 玉置尚徳; 吹谷智; 横田篤; 片山高嶺, 2018, 29, 2
• ビフィズス菌由来ATPase MsiKはABCトランスポーターを介した糖質取込みをグローバルに制御する, 前田信悟; 阪中幹祥; 後藤愛那; 村上隆太; 加藤紀彦; 杉山友太; 谷内寛之; 栗原新; 玉置尚徳; 吹谷智; 横田篤; 片山高嶺, 2018, 2018
• 尿路感染症菌Proteus mirabilisの新規プトレッシンエクスポーターの探索, 太田宏一; 阪中幹祥; 杉山友太; 栗原新, 2018, 10th

Presentations

• Functional analysis of a barley β-glucan utilization gene cluster in Segatella copri JCM 13464T, Momoko Oyama, Yusuke Hashimoto, Yoko Sagara, Nahoko Kitamura, Shigenobu Kishino, Hideru Obinata, Haruyoshi Tomita, Yuta Sugiyama, Gunma International Symposium 2025 on Biomolecular Science and Membrane Application, 23 Jan. 2025, 23 Jan. 2025, International conference
• ヒト腸内細菌Segatella copriの大麦β-グルカン代謝遺伝子群の同定, 大山 ももこ, 橋本 佑輔, 相良 陽子, 北村 苗穂子, 岸野 重信, 大日方 英, 富田 治芳, 杉山 友太, 日本農芸化学会関東支部2024年度大会, 30 Aug. 2024, 30 Aug. 2024
• Segatella copri JCM 13464Tの大麦 β-グルカン代謝遺伝子群の同定, 大山ももこ, 橋本佑輔, 相良陽子, 北村苗穂子, 岸野重信, 大日方 英, 富田治芳, 杉山友太, 日本乳酸菌学会2024年度大会, 20 Jul. 2024, 19 Jul. 2024, 20 Jul. 2024
• Towards understanding gallic acid formation in persimmon fruits; characterization of the dehydroquinate dehydratase/shikimate dehydrogenases (DHD/SDHs), Ayako Katayama-Ikegami, Tomoaki Sakamoto, Takane Katayama, Yuta Sugiyama, Mei Gao-Takai, Tomoya Esumi, 7th International Symposium on Persimmon, 27 Sep. 2021, 30 Sep. 2021, English, International conference
• 腸内細菌の芳香族アミン産生と宿主末梢セロトニン産生への寄与, 杉山友太, 森裕美子, 奈良未沙希, 小谷勇介, 永井栄美子, 河田明輝, 北村真悠, 平野里佳, 下川ひろみ, 中川明, 南博道, 後藤愛那, 阪中幹祥, 飯田宗穂, 小栁喬, 片山高嶺, 岡本成史, 栗原新, 第2回腸内デザイン学会年会, 15 Nov. 2022, 15 Nov. 2022, 15 Nov. 2022, Japanese
• Aromatic amine production in human gut bacteria: the role of aromatic amino acid decarboxylase in serotonin production, Yuta Sugiyama, Emiko Nagai, Akira Nakagawa, Hiromichi Minami, Mikiyasu Sakanaka, Noriho Iida, Takashi Koyanagi, Takane Katayama, Shigefumi Okamoto, Shin Kurihara, IUNS-ICN 22nd International Congress of Nutrition, 06 Dec. 2022, 11 Dec. 2022, English

Industrial Property Rights

• Patent right, 特願2019-026780, 18 Feb. 2019, ; , 特開2020-132558, 31 Aug. 2020

Awards

• Nov. 2017, Japan society

  対象リソースIRI
• Oct. 2015, Japan society
• ICoFF Poster Award, Yuta Sugiyama;Masakazu Takahashi;Kyuichi Kawabata;Kazuhiro Irie;Hajime Ohigashi, Identification of Nitric oxide generation-inhibitors of Zizyphus jujuba, and analysis of the molecular mechanisms, The 2011 International Conference on Food Factors, Nov. 2011, International society

Academic Contribution

• Competition etc, 27 Mar. 2024, 28 Mar. 2024
• Competition etc, 28 Mar. 2024, 28 Mar. 2024

Educational Activities

Teaching Experience

• Gunma University, 2021, 9999
• Environmental Engineering and Science, Gunma University, 2021, 9999, Undergraduate special subjects, Japan
• Futurology of Gunma, Gunma University, 2021, 9999, Undergraduate liberal arts, Japan

Awards

• Others
• 19 Oct. 2024, Others
• 08 Jul. 2023, Others

Social Contribution

Social Contribution

• 食事と腸内細菌, 04 Sep. 2024, 15 Sep. 2024
• 群馬名物みそぱんをつくってみよう！, Gunma University, 02 Aug. 2023, 22 Aug. 2023, Internet　(Target:　Infants, Schoolchildren, Junior high school students, Teachers, Guardians)
• リカレント教育講座「食の栄養機能と代謝調節」, 28 Aug. 2023, 01 Sep. 2023　(Target:　Teachers, Researchers, General, Company)
• リカレント教育講座「食の栄養機能と代謝調節」, 12 Dec. 2022, 16 Dec. 2022, Online, Others　(Target:　Teachers, Researchers, General, Company)
• 微生物の力で食品づくり, Gunma University, 02 Aug. 2021, 22 Aug. 2021, Internet　(Target:　Infants, Schoolchildren, Junior high school students, Teachers, Guardians, General, Civic organization)