Researcher Profile and Settings

Researcher

• Name

  Suzuki Tomohiro

Affiliation

• Biosignal Genome Resource Center, Assistant Professor

Profile and Settings

• Name

  Tomohiro, Suzuki

Alternate Names

• Suzuki T

Affiliation

• Gunma University, Assistant Professor
• Gunma University, Assistant Professor

Affiliation

• Affiliation

  Institute for Molecular and Cellular Regulation, Signal Transduction Field

Education

• Apr. 2014, Mar. 2017, Waseda University, Graduate School of Advanced Science and Engineering
• Apr. 2012, Mar. 2014, Waseda University, Graduate School of Advanced Science and Engineering
• Apr. 2008, Mar. 2012, Waseda University, School of Advanced Science and Engineering

Degree

• Doctor of Science, Waseda University, Jun. 2018

Association Memberships

• The Japanese Society for Epigenetics, 2023, 9999
• The Japan Endocrine Society, 2020, 9999
• Jan. 2023, 9999
• Apr. 2021, Mar. 2023

Research Experience

• Apr. 2017, 9999, Gunma University, Assistant prof lv

Research Activities

Research Areas

• Life sciences, Genomics
• Life sciences, Cell biology
• Life sciences, Molecular biology

Published Papers

• Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity, Tomohiro Suzuki, Tetsuro Komatsu, Hiroshi Shibata, Akiko Tanioka, Diana Vargas, Reika Kawabata-Iwakawa, Fumihito Miura, Shinnosuke Masuda, Mayuko Hayashi, Kyoko Tanimura-Inagaki, Sumiyo Morita, Junki Kohmaru, Koji Adachi, Masayuki Tobo, Hideru Obinata, Tasuku Hirayama, Hiroshi Kimura, Juro Sakai, Hideko Nagasawa, Hideyuki Itabashi, Izuho Hatada, Takashi Ito, Takeshi Inagaki, May 2023, Nucleic Acids Research

  DOI
• Hypoxia and fatty liver, Suzuki, Tomohiro; Shinjo, Satoko; Arai, Takatomo; Kanai, Mai; Goda, Nobuhito, Nov. 2014, WORLD JOURNAL OF GASTROENTEROLOGY

  DOI
• Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid induced insulin resistance, Shinjo, Satoko; Jiang, Shuying; Nameta, Masaaki; Suzuki, Tomohiro; Kanai, Mai; Nomura, Yuta; Goda, Nobuhito, Oct. 2017, EXPERIMENTAL CELL RESEARCH

  DOI
• Type I neuregulin1 alpha is a novel local mediator to suppress hepatic gluconeogenesis in mice, Arai, Takatomo; Ono, Yumika; Arimura, Yujiro; Sayama, Keimon; Suzuki, Tomohiro; Shinjo, Satoko; Kanai, Mai; Abe, Shin-ichi; Semba, Kentaro; Goda, Nobuhito, 2017, SCIENTIFIC REPORTS

  DOI
• Loss of hypoxia inducible factor-1alpha aggravates gamma delta T cell-mediated inflammation during acetaminophen-induced liver injury, Suzuki T, Minagawa S, Yamazaki T, Arai T, Kanai M, Shinjo S, Goda N, 2018, Hepatology Communications, 2, 5, 571, 581

  DOI
• Epigenetic regulation of beige adipocyte fate by histone methylation, Tanimura, Kyoko;Suzuki, Tomohiro;Vargas, Diana;Shibata, Hiroshi;Inagaki, Takeshi, 2019, ENDOCRINE JOURNAL, 66, 2, 115, 125

  DOI
• T1R3 homomeric sweet taste receptor negatively regulates insulin-induced glucose transport through Gas-mediated microtubules disassembly in 3T3-L1 adipocytes, Masubuchi, Yosuke;Ma, Jinhui;Suzuki, Tomohiro;Kojima, Itaru;Inagaki, Takeshi;Shibata, Hiroshi, 2022, ENDOCRINE JOURNAL, 69, 5, 487, 493
• エピゲノム編集による脂肪分化制御への挑戦, ;;;;;;;;;;;;, Apr. 2021, 97, 1, 332
• Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals., Suzuki Tomohiro;Hayashi Mayuko;Komatsu Tetsuro;Tanioka Akiko;Nagasawa Masahiro;Tanimura-Inagaki Kyoko;Rahman Mohammad Sharifur;Masuda Shinnosuke;Yusa Kosuke;Sakai Juro;Shibata Hiroshi;Inagaki Takeshi, Jul. 2021, Endocrine journal, 68, 12

  DOI
• Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity., Yoshida Naofumi;Yamashita Tomoya;Osone Tatsunori;Hosooka Tetsuya;Shinohara Masakazu;Kitahama Seiichi;Sasaki Kengo;Sasaki Daisuke;Yoneshiro Takeshi;Suzuki Tomohiro;Emoto Takuo;Saito Yoshihiro;Ozawa Genki;Hirota Yushi;Kitaura Yasuyuki;Shimomura Yoshiharu;Okamatsu-Ogura Yuko;Saito Masayuki;Kondo Akihiko;Kajimura Shingo;Inagaki Takeshi;Ogawa Wataru;Yamada Takuji;Hirata Ken-Ichi, Oct. 2021, iScience, 24, 11

  DOI
• Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Akiko Tanioka; Diana Vargas; Reika Kawabata-Iwakawa; Fumihito Miura; Shinnosuke Masuda; Mayuko Hayashi; Kyoko Tanimura-Inagaki; Sumiyo Morita; Junki Kohmaru; Koji Adachi; Masayuki Tobo; Hideru Obinata; Tasuku Hirayama; Hiroshi Kimura; Juro Sakai; Hideko Nagasawa; Hideyuki Itabashi; Izuho Hatada; Takashi Ito; Takeshi Inagaki, 09 May 2023, Nucleic Acids Research, 51, 12, 6120, 6142, Scientific journal

  DOI
• T1R3 homomeric sweet taste receptor negatively regulates insulin-induced glucose transport through Gαs-mediated microtubules disassembly in 3T3-L1 adipocytes., Yosuke Masubuchi; Jinhui Ma; Tomohiro Suzuki; Itaru Kojima; Takeshi Inagaki; Hiroshi Shibata, 30 May 2022, Endocrine journal, 69, 5, 487, 493, Scientific journal

  DOI
• Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals., Tomohiro Suzuki; Mayuko Hayashi; Tetsuro Komatsu; Akiko Tanioka; Masahiro Nagasawa; Kyoko Tanimura-Inagaki; Mohammad Sharifur Rahman; Shinnosuke Masuda; Kosuke Yusa; Juro Sakai; Hiroshi Shibata; Takeshi Inagaki, 28 Dec. 2021, Endocrine journal, 68, 12, 1429, 1438, Scientific journal

  DOI
• Metabolic Responses to Energy-Depleted Conditions, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Takeshi Inagaki, 01 Dec. 2021, Intechpen: Psychology and Pathophysiological Outcomes of Eating, In book

  DOI
• Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity., Naofumi Yoshida; Tomoya Yamashita; Tatsunori Osone; Tetsuya Hosooka; Masakazu Shinohara; Seiichi Kitahama; Kengo Sasaki; Daisuke Sasaki; Takeshi Yoneshiro; Tomohiro Suzuki; Takuo Emoto; Yoshihiro Saito; Genki Ozawa; Yushi Hirota; Yasuyuki Kitaura; Yoshiharu Shimomura; Yuko Okamatsu-Ogura; Masayuki Saito; Akihiko Kondo; Shingo Kajimura; Takeshi Inagaki; Wataru Ogawa; Takuji Yamada; Ken-Ichi Hirata, 19 Nov. 2021, iScience, 24, 11, 103342, 103342, Scientific journal

  DOI
• Epigenetic regulation of beige adipocyte fate by histone methylation., Kyoko Tanimura; Tomohiro Suzuki; Diana Vargas; Hiroshi Shibata; Takeshi Inagaki, 28 Feb. 2019, Endocrine journal, 66, 2, 115, 125, Scientific journal

  DOI
• Loss of hypoxia inducible factor-1α aggravates γδ T-cell-mediated inflammation during acetaminophen-induced liver injury., Tomohiro Suzuki; Shoko Minagawa; Takashi Yamazaki; Takatomo Arai; Mai Kanai; Satoko Shinjo; Nobuhito Goda, May 2018, Hepatology communications, 2, 5, 571, 581, Scientific journal

  DOI
• Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance., Satoko Shinjo; Shuying Jiang; Masaaki Nameta; Tomohiro Suzuki; Mai Kanai; Yuta Nomura; Nobuhito Goda, 01 Oct. 2017, Experimental cell research, 359, 1, 86, 93, Scientific journal

  DOI
• Type I neuregulin1α is a novel local mediator to suppress hepatic gluconeogenesis in mice., Takatomo Arai; Yumika Ono; Yujiro Arimura; Keimon Sayama; Tomohiro Suzuki; Satoko Shinjo; Mai Kanai; Shin-Ichi Abe; Kentaro Semba; Nobuhito Goda, 20 Feb. 2017, Scientific reports, 7, 42959, 42959, Scientific journal

  DOI
• Hypoxia and fatty liver., Tomohiro Suzuki; Satoko Shinjo; Takatomo Arai; Mai Kanai; Nobuhito Goda, 07 Nov. 2014, World journal of gastroenterology, 20, 41, 15087, 97, Scientific journal

  DOI
• Iron‐Dependent JMJD1A‐Mediated Demethylation of H3K9me2 Regulates Gene Expression During Adipogenesis in a Spatial Genome Organization‐Dependent Manner, Shinnosuke Masuda; Tetsuro Komatsu; Safiya Atia; Tomohiro Suzuki; Mayuko Hayashi; Atsushi Toyoda; Hiroshi Kimura; Takeshi Inagaki, 28 Apr. 2025, Genes to Cells, 30, 3, Scientific journal

  DOI
• ヒストン脱メチル化酵素JMJD1Aによる鉄依存的な脂肪細胞分化制御のマルチオミクス解析, ;;;, Nov. 2024, 97回, [2T06

Books etc

• Psychology and Pathophysiological Outcomes of Eating, Joint work, Tomohiro Suzuki, Tetsuro Komatsu, Hiroshi Shibata and Takeshi Inagaki, Metabolic Responses to Energy-Depleted Conditions, IntechOpen, 2021
• 呼吸器NEWS＆VIEWS, 2012
• 代謝，発生，免疫で動き出す 低酸素応答システム, 2012

Presentations

• 鉄が制御する脂肪細胞分化のエピゲノム機構, 鈴木智大, 第17回日本エピジェネティクス研究会年会, 14 Jun. 2024, 13 Jun. 2024, 14 Jun. 2024, Japanese
• 脂肪細胞分化における細胞核内の鉄濃度変化測定法の開発, 鈴木智大, 第22回生体機能研究会, 07 Sep. 2024, 06 Sep. 2024, 07 Sep. 2024, Japanese
• JMJD1AとTET2は鉄代謝による活性調節により脂肪細胞分化を制御する, 鈴木智大, 第46回日本分子生物学会年会, 08 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023, Japanese
• JMJD1AとTET2は鉄依存的に白色脂肪細胞分化を制御する, 鈴木智大, 第９回生体調節研究所内分泌代謝シンポジウム, 07 Sep. 2023, 07 Sep. 2023, 08 Sep. 2023, Japanese
• Iron-dependent epigenetic regulations of adipocyte differentiation via JMJD1A and TET2, 鈴木智大, The 8th IMCR Symposium, 10 Nov. 2022, 10 Nov. 2022, 11 Nov. 2022, Japanese
• 白色脂肪細胞分化を制御する鉄依存的エピゲノム制御機構の解明, 鈴木智大, ABUS2023, 05 Aug. 2023, 05 Aug. 2023, 05 Aug. 2023, Japanese
• JMJD1A and TET2 regulate white adipocyte differentiation in an iron- dependent manner, 鈴木智大, DESIRE conference 2022, 03 Jul. 2022, 03 Jul. 2022, 03 Jul. 2022, Japanese
• エピゲノム編集による脂肪分化制御への挑戦, 鈴木智大，Silvia Bolzani，小松哲郎，Diana Vargas，Sharifur Rahman，谷村恭子，林真友子，谷岡安紀子，森田純代，堀居拓郎，畑田出穂，柴田宏，稲垣毅, 第94回日本内分泌学会学術集会, 2021, Domestic conference
• 脂肪細胞分化制御因子としての鉄イオンの役割とその細胞内動態, 柴田 宏，鈴木 智大，谷岡 安紀子，谷村 恭子，Diana Vargas，Silvia Bolzani，林 真友子，板橋 英之，稲垣 毅, 第34回日本糖尿病・肥満動物学会年次学術集会, 2020, Domestic conference
• Role of Epitranscriptome in the Metabolism of Adipose Tissue, Vargas D,Suzuki T, Komatsu T, Rahman S, Bolzani S, Shibata H, Inagaki T, 14th Colombian Congress in Obesity, 2021, International conference
• The Role of Demethylases during Adipocyte Differentiation of 3T3-L1 Cells, Vargas D, Suzuki T, Komatsu T, Rahman S, Bolzani S. Shibata H, Inagaki T, Keystone eSymposium, 2020, International conference
• Regulation of 3T3-L1 differentiation by the enzymes which mediate mRNA methylation, Vargas Trujillo D, Suzuki T, Shibata H, Bolzani S, Inagaki T, The 5th IMCR symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2019, Domestic conference
• Role of iron in adipogenic differentiation of 3T3-L1 cells, Shibata H, Suzuki T, Tanimura K, Vargas D, Hirayama T, Nagasawa H, Inagaki T, The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2018, Domestic conference
• An exploratory research for the regulation of adipocyte differentiation by artificial editing of a histone methylation, Suzuki T, Bolzani S, Vargas D, Morita S,Horii T,Hatada I, Shibata H, Inagaki T, The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2018, Domestic conference
• 脂肪細胞分化における細胞核内の鉄濃度変化測定法の開発, 鈴木智大, 第22回生体機能研究会, 07 Sep. 2024, 06 Sep. 2024, 07 Sep. 2024, Japanese
• 鉄が制御する脂肪細胞分化のエピゲノム機構, 鈴木智大, 第17回日本エピジェネティクス研究会年会, 14 Jun. 2024, 13 Jun. 2024, 14 Jun. 2024, Japanese
• JMJD1AとTET2は鉄代謝による活性調節により脂肪細胞分化を制御する, 鈴木智大, 第46回日本分子生物学会年会, 08 Dec. 2023, 06 Dec. 2023, 08 Dec. 2023, Japanese
• JMJD1AとTET2は鉄依存的に白色脂肪細胞分化を制御する, 鈴木智大, 第９回生体調節研究所内分泌代謝シンポジウム, 07 Sep. 2023, 07 Sep. 2023, 08 Sep. 2023, Japanese
• 白色脂肪細胞分化を制御する鉄依存的エピゲノム制御機構の解明, 鈴木智大, ABUS2023, 05 Aug. 2023, 05 Aug. 2023, 05 Aug. 2023, Japanese
• Iron-dependent epigenetic regulations of adipocyte differentiation via JMJD1A and TET2, 鈴木智大, The 8th IMCR Symposium, 10 Nov. 2022, 10 Nov. 2022, 11 Nov. 2022, Japanese
• JMJD1A and TET2 regulate white adipocyte differentiation in an iron- dependent manner, 鈴木智大, DESIRE conference 2022, 03 Jul. 2022, 03 Jul. 2022, 03 Jul. 2022, Japanese
• Role of Epitranscriptome in the Metabolism of Adipose Tissue, Vargas D,Suzuki T, Komatsu T, Rahman S, Bolzani S, Shibata H, Inagaki T, 14th Colombian Congress in Obesity, 2021, International conference
• エピゲノム編集による脂肪分化制御への挑戦, 鈴木智大,Silvia Bolzani,小松哲郎,Diana Vargas,Sharifur Rahman,谷村恭子,林真友子,谷岡安紀子,森田純代,堀居拓郎,畑田出穂,柴田宏,稲垣毅, 第94回日本内分泌学会学術集会, 2021, Domestic conference
• The Role of Demethylases during Adipocyte Differentiation of 3T3-L1 Cells, Vargas D, Suzuki T, Komatsu T, Rahman S, Bolzani S. Shibata H, Inagaki T, Keystone eSymposium, 2020, International conference
• 脂肪細胞分化制御因子としての鉄イオンの役割とその細胞内動態, 柴田 宏,鈴木 智大,谷岡 安紀子,谷村 恭子,Diana Vargas,Silvia Bolzani,林 真友子,板橋 英之,稲垣 毅, 第34回日本糖尿病・肥満動物学会年次学術集会, 2020, Domestic conference
• Regulation of 3T3-L1 differentiation by the enzymes which mediate mRNA methylation, Vargas Trujillo D, Suzuki T, Shibata H, Bolzani S, Inagaki T, The 5th IMCR symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2019, Domestic conference
• An exploratory research for the regulation of adipocyte differentiation by artificial editing of a histone methylation, Suzuki T, Bolzani S, Vargas D, Morita S,Horii T,Hatada I, Shibata H, Inagaki T, The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2018, Domestic conference
• Role of iron in adipogenic differentiation of 3T3-L1 cells, Shibata H, Suzuki T, Tanimura K, Vargas D, Hirayama T, Nagasawa H, Inagaki T, The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research, 2018, Domestic conference
• How does iron metabolism contribute to epigenomic regulation during adipocyte differentiation?, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Akiko Tanioka; Reika Kawabata; Fumihito Miura; Shinnosuke Masuda; Mayuko Hayashi; Kyoko Tanimura; Takashi Ito; Takeshi Inagaki, 第47回日本分子生物学会年会, 29 Nov. 2024, 27 Nov. 2924, 29 Nov. 2924, Japanese
• The role of iron in epigenetic regulation during adipocyte differentiation, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Shinnosuke Masuda; Akiko Tanioka; Mayuko Hayashi; Takeshi Inagaki, The 10th IMCR Symposium on Endocrine and Metabolism 2024, 31 Oct. 2024, 01 Nov. 2024, English
• Iron-dependent epigenetic regulations of adipocyte differentiation via JMJD1A and TET2, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Shinnosuke Masuda; Akiko Tanioka; Mayuko Hayashi; Kyoko Tanimura; Fumihito Miura; Takashi Ito; Takeshi Inagaki, The 19th International Symposium of the Institute Network for Biomedical Sciences in Sendai, 11 Oct. 2024, 10 Oct. 2024, 11 Oct. 2024, English

Awards

• The Young Investigator Award from the Institute of Biological Regulation, 26 Feb. 2024
• The Young Investigator Award from the Institute of Biological Regulation, 26 Feb. 2024

Research Projects

• 01 Apr. 2022, 31 Mar. 2025, 22K15081

  対象リソースIRI
• Artificial regulation of adipocyte differentiation by histone editing using a SunTag method, Suzuki Tomohiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Gunma University, 01 Apr. 2019, 31 Mar. 2022, Obesity accounts for 20-30% of the Japanese population and is a risk factor for lifestyle-related diseases. In this study, we aimed to inhibit differentiation of adipose progenitor cells into mature adipocytes by artificially controlling chemical modifications of histones that contribute to gene expression without altering the genetic information of the cells. This method successfully suppressed the expression of genes involved in adipocyte differentiation and prevented terminal differentiation into adipocytes by recruiting a histone modifying enzyme in the gene region that regulates adipocyte differentiation. This research is expected to contribute to the development of treatments for obesity in the future., 19K16100

  対象リソースIRI

Academic Contribution

• Others, 17 Mar. 2023, 17 Mar. 2023
• DESIRE Conference 2022, 03 Jul. 2022, 03 Jul. 2022
• The 8th IMCR Symposium on Endocrine and Metabolism: Beyond the Frontiers of Endocrinology & Metabolism, Competition etc, 10 Nov. 2023, 11 Nov. 2023
• Others, 18 Mar. 2022, 18 Mar. 2022
• Others, 26 Nov. 2021, 26 Nov. 2021
• The 15th International Symposium of the Institute Network for Biomedical Sciences Cutting Edge of Biomedical and Metabolic Sciences, Competition etc, Takeshi Inagaki, 05 Nov. 2020, 06 Nov. 2020, Gunma University, International academic contribution
• Others, 17 Dec. 2021, 17 Dec. 2021
• Others, 20 Dec. 2021, 20 Dec. 2021

Social Contribution

Social Contribution

• ’23 summer オープンラボ student programme, 04 Aug. 2023, 05 Aug. 2023
• 前橋女子高の最先端生命科学セミナー, 11 Mar. 2023, 11 Mar. 2023　(Target:　High school students, Media)
• 動画作成委員としての活動, 01 Apr. 2021, 31 Mar. 2022, Others
• 代謝エピジェネティクス分野の研究 (ご紹介動画シリアルNo. 0001) (YouTube動画), 2021, 2022　(Target:　Junior high school students, High school students, College students, Graduate students, Teachers, Guardians, General)
• ちびっこ大学, 2017　(Target:　Schoolchildren, Junior high school students)
• 高等学校出前授業 「後天性を決めるエピゲノム」渋川女子高校, 2018　(Target:　High school students)
• まちなかキャンパス　「太りやすい体質」の最新科学, 2019　(Target:　General)
• Epigenetics and adipose cell development, 26 Feb. 2019, Visiting lecture　(Target:　High school students, Teachers)
• 研究所広報のため動画担当委員の担当, 2020　(Target:　Infants, Schoolchildren, Junior high school students, High school students, College students, Graduate students, Teachers, Guardians, Researchers, General, Scientific organization)
• 高等学校出前授業 「後天性を決めるエピゲノム」渋川女子高校, 02 Dec. 2024　(Target:　High school students)