Researcher Profile and Settings

Researcher

• Name

  Hirai HIROKAZU

Affiliation

• Neurophysiology and Neural Repair, Professor

Profile and Settings

• Name

  Hirai, Hirokazu

Alternate Names

• Hirokazu Hirai

ホームページ

• URI

  http://synapse.dept.med.gunma-u.ac.jp/index.html

• URI

  http://www.med.gunma-u.ac.jp/neurophysiol/

Foreign language

• Use in presentation

  English, English

• Use in publication

  English, English

Affiliation

• -
• -

Affiliation

• Affiliation

  Graduate School of Medicine, Neurophysiology and Neural Repair

• Job title

  Professor

Education

• Mar. 1994, Kobe University, Graduate School, Division of Medicine, Neurophysiology, Kobe University, Graduate School, Division of Medicine, Doctor, Completion, Domestic
• Mar. 1989, Kobe University, Faculty of Medicine, Kobe University

Association Memberships

• Japan Neuroscience Society

Research Experience

• Oct. 2019, 9999, Gunma University Viral Vector Core, Director, Executive
• Apr. 2014, Sep. 2019, Gunma University Initiative for Advanced Research, Research Program for Neural Signaling, Program Director
• Apr. 2011, Mar. 2015, Gunma University Graduate School of Medicine, Division of Neuroscience, Chairman
• 2006, 9999, Gunma University, Graduate School of Medicine, Prof lv
• 2006, 2008, Prof lv
• 2004, 2006, Kanazawa University, Advanced Science Research Center, Associate prof lecturer lv
• 1997, 2001, Researcher postdoc lv
• 1996, 1997
• 2009, 9999, Gunma University, Institute for Molecular and Cellular Regulation, Executive
• 1994, 1996
• 2001, 2002
• Apr. 1990, Mar. 1994, Kobe University, Graduate School of Medicine, Others
• Jun. 1989, Mar. 1990, Kobe University, University Hospital
• Mar. 1989, Kobe University, School of Medicine, Faculty of Medicine
• 2003, 2004

Research Activities

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general
• Life sciences, Physiology
• Life sciences, Clinical pharmacy
• Life sciences, Laboratory animal science
• Life sciences, Radiology
• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general

Research Themes

• Moleclular mechanism underlying synaptic plasticity, Synaptogenesis LTD, Personal, 2002, -, General Neuroscience, Nerve Chemistry/ Nerve Pharmacology, 0085 (Japanese Only)
• Development of gene therapy for the spinocerebellar ataxia, Lentivirus, Spinocerebellar ataxia, Gene therapy, Domestic Collaboration, 2003, -, General Neuroscience, Nerve Chemistry/ Nerve Pharmacology, Neurology, JST Precursory Research for Embryonic Science and Technology (PRESTO)

Published Papers

• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation., Erika Ueda; Tomoko Ohta; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Hiroshi Katsuki; Takahiro Seki, 05 Apr. 2022, Cells, 11, 7, Scientific journal

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells., Hirokazu Hirai; Yuuki Fukai; Ayumu Konno; Nobutake Hosoi, 26 Feb. 2022, Cerebellum (London, England), Scientific journal

  DOI
• Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain., Aya Sakai; Takeshi Yasui; Masashi Watanave; Rine Tatsumi; Yoshihiko Yamamoto; Wataru Takano; Yuki Tani; Izumi Okamura; Hirokazu Hirai; Shigeki Takeda, 23 Feb. 2022, Genes to cells : devoted to molecular & cellular mechanisms, Scientific journal

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination., Masashi Watanave; Nobutaka Takahashi; Nobutake Hosoi; Ayumu Konno; Hikaru Yamamoto; Hiroyuki Yasui; Mika Kawachi; Takuro Horii; Yasunori Matsuzaki; Izuho Hatada; Hirokazu Hirai, 15 Feb. 2022, Proceedings of the National Academy of Sciences of the United States of America, 119, 7, Scientific journal

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating., Akinobu Suzuki; Sakurako Kosugi; Emi Murayama; Eri Sasakawa; Noriaki Ohkawa; Ayumu Konno; Hirokazu Hirai; Kaoru Inokuchi, 11 Jan. 2022, Nature communications, 13, 1, 41, 41, Scientific journal

  DOI
• The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice., Ayane Ninomiya; Abdallah Mshaty; Asahi Haijima; Hiroyuki Yajima; Michifumi Kokubo; Miski Aghnia Khairinisa; Winda Ariyani; Yuki Fujiwara; Sumiyasu Ishii; Nobutake Hosoi; Hirokazu Hirai; Izuki Amano; Noriyuki Koibuchi, Jan. 2022, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 159, 112751, 112751, Scientific journal

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury., Ryo Kawakami; Miki Matsui; Ayumu Konno; Ryosuke Kaneko; Shreya Shrestha; Suman Shrestha; Hiroaki Sunaga; Hirofumi Hanaoka; Sawako Goto; Michihiro Hosojima; Hideyuki Kabasawa; Masaru Obokata; Norimichi Koitabashi; Hiroki Matsui; Tsutomu Sasaki; Akihiko Saito; Motoko Yanagita; Hirokazu Hirai; Masahiko Kurabayashi; Tatsuya Iso, Dec. 2021, The Journal of pathology, 255, 4, 362, 373, Scientific journal

  DOI
• Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia., Tomoko Ohta; Yuri Morikawa; Masahiro Sato; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki; Takahiro Seki, Sep. 2021, Experimental neurology, 343, 113791, 113791, Scientific journal

  DOI
• Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications., Jan Cendelin; Marija Cvetanovic; Mandi Gandelman; Hirokazu Hirai; Harry T Orr; Stefan M Pulst; Michael Strupp; Filip Tichanek; Jan Tuma; Mario Manto, 10 Aug. 2021, Cerebellum (London, England), Scientific journal

  DOI
• Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1, Shuvaev AN, Belozor OS, Mozhei O, Yakovleva DA, Potapenko IV, Shuvaev AN, Smolnikova MV, Salmin VV, Salmina AB, Hirai H, Teschemacher AG, Kasparov S., Jul. 2021, Neurobiology of Disease, 154, 105340

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Putri T. Radhiyanti; Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, Jun. 2021, Neuroscience Letters, 756, 135956, 135956, Scientific journal

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia, Yasui H, Matsuzaki Y, Konno A, Hirai H., 10 May 2021, Neuroscience, 462, 328, 336

  DOI
• Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum, Nagao S, Hirai H, Kano M, Yuzaki M., May 2021, Neuroscience, 462, 1, 3

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• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice, Sugimoto H, Horii T, Hirota JN, Sano Y, Shinoda Y, Konno A, Hirai H, Ishizaki Y, Hirase H, Hatada I, Furuichi T, Sadakata T., 12 Mar. 2021, Molecular Brain, 14, 1, 52

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter, Hoshino C, Konno A, Hosoi N, Kaneko R, Mukai R, Nakai J, Hirai H., 15 Feb. 2021, Molecular Brain, 14, 1, 33

  DOI
• Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome, Ohgami N, Iizuka A, Hirai H, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M., 06 Feb. 2021, Journal of Biological Chemistry, 296, 100389

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons, Sato M, Ohta T, Morikawa Y, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T., Feb. 2021, Neuropathology and Applied Neurobiology, 47, 2, 198, 209

  DOI
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB, Konno A, Hirai H., 01 Dec. 2020, Journal of Neuroscience Method, 346, 108914

  DOI
• Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System, Inoue A, Kobayashi T, Hirai H, Kanaya N, Kohara K., 25 Nov. 2020, STAR Protocols, 1, 3, 100166
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB., Konno Ayumu;Hirai Hirokazu, 15 Aug. 2020, Journal of neuroscience methods, 346

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons., Sato Masahiro;Ohta Tomoko;Morikawa Yuri;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, 28 Jul. 2020, Neuropathology and applied neurobiology

  DOI
• Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy, Sato M, Ueda E, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H, Seki T., 12 Jul. 2020, Biochemical and Biophysical Research Communication, 528, 1, 199, 205

  DOI
• Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance., Yuki Oe; Xiaowen Wang; Tommaso Patriarchi; Ayumu Konno; Katsuya Ozawa; Kazuko Yahagi; Hirokazu Hirai; Takashi Tsuboi; Tetsuya Kitaguchi; Lin Tian; Thomas J McHugh; Hajime Hirase, 07 Jul. 2020, Nature communications, 11, 1, 3447, 3447, Scientific journal

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• BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System, Kohara K, Inoue A, Nakano Y, Hirai H, Kobayashi T, Maruyama M, Baba R, Kawashima C., 26 Jun. 2020, iScience, 23, 6, 101248

  DOI
• Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism, Chao OY, Marron Fernandez de Velasco E, Pathak SS, Maitra S, Zhang H, Duvick L, Wickman K, Orr HT, Hirai H, Yang YM., Jun. 2020, Neuropsychopharmacology, 45, 7, 1159, 1170

  DOI
• Glucocorticoids negatively regulates chaperone mediated autophagy and microautophagy., Sato Masahiro;Ueda Erika;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, 30 May 2020, Biochemical and biophysical research communications, 528, 1

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia., Yasui Hiroyuki;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 08 Apr. 2020, Neuroscience

  DOI
• Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism., Chao Owen Y;Marron Fernandez de Velasco Ezequiel;Pathak Salil Saurav;Maitra Swati;Zhang Hao;Duvick Lisa;Wickman Kevin;Orr Harry T;Hirai Hirokazu;Yang Yi-Mei, 16 Mar. 2020, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45, 7

  DOI
• Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons, Ryu Y, Maekawa T, Yoshino D, Sakitani N, Takashima A, Inoue T, Suzurikawa J, Toyohara J, Tago T, Makuuchi M, Fujita N, Sawada K, Murase S, Watanave M, Hirai H, Sakai T, Yoshikawa Y, Ogata T, Shinohara, 21 Feb. 2020, iScience, 23, 2, 100874

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• 甲状腺ホルモン受容体による小脳プルキンエ細胞におけるシナプス可塑性の調節機構, 二ノ宮 彩音; 細井 延武; 小久保 倫文; 天野 出月; はい島 旭; 宮崎 航; 平井 宏和; 鯉淵 典之, Feb. 2020, 95, 4, 1342, 1342
• Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons., Ryu Youngjae;Maekawa Takahiro;Yoshino Daisuke;Sakitani Naoyoshi;Takashima Atsushi;Inoue Takenobu;Suzurikawa Jun;Toyohara Jun;Tago Tetsuro;Makuuchi Michiru;Fujita Naoki;Sawada Keisuke;Murase Shuhei;Watanave Masashi;Hirai Hirokazu;Sakai Takamasa;Yoshikawa Yuki;Ogata Toru;Shinohara Masahiro;Nagao Motoshi;Sawada Yasuhiro, 31 Jan. 2020, iScience, 23, 2

  DOI
• Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance, Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tian L, McHugh TJ, Hirase H., 24 Jan. 2020, NATURE COMMUNICATIONS, 11, 1, 471

  DOI
• Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism, Chao, Owen Y.;de Velasco, Ezequiel Marron Fernandez;Pathak, Salil Saurav;Maitra, Swati;Zhang, Hao;Duvick, Lisa;Wickman, Kevin;Orr, Harry T.;Hirai, Hirokazu;Yang, Yi-Mei, 2020, NEUROPSYCHOPHARMACOLOGY, 45, 7, 1159, 1170

  DOI
• Ataxic phenotype and neurodegeneration are triggered by the impairment of chaperone-mediated autophagy in cerebellar neurons, Sato, Masahiro;Ohta, Tomoko;Morikawa, Yuri;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi;Seki, Takahiro, 2020, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

  DOI
• Establishment of World Premier Viral Vector Core, Hirai Hirokazu, 2020, The Kitakanto Medical Journal, 70, 3, 277, 279
• Advanced CUBIC tissue clearing for whole-organ cell profiling, Matsumoto K, Mitani TT, Horiguchi SA, Kaneshiro J, Murakami TC, Mano T, Fujishima H, Konno A, Watanabe TM, Hirai H, Ueda HR., Dec. 2019, Nature Protocols, 14, 12, 3506, 3537

  DOI
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, ;;;;;;, Sep. 2019, 92回, [1T14a
• 【小脳学習説Marr-Albus-Ito理論の50年】機能障害と治療　ウイルスベクター経静脈投与による脊髄小脳変性症動物モデルの作出, 平井 宏和, Aug. 2019, 37, 8, 998
• Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments., Hosoi Nobutake;Shibasaki Koji;Hosono Mayu;Konno Ayumu;Shinoda Yo;Kiyonari Hiroshi;Inoue Kenichi;Muramatsu Shin-Ichi;Ishizaki Yasuki;Hirai Hirokazu;Furuichi Teiichi;Sadakata Tetsushi, 14 Jun. 2019, The Journal of neuroscience : the official journal of the Society for Neuroscience, 39, 32

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• Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?, Cendelin J; Buffo A; Hirai H; Magrassi L; Mitoma H; Sherrard R; Vozeh F; Manto M, Jun. 2019, Cerebellum (London, England), 18, 3, 575, 592

  DOI
• Rapamycin activates mammalian microautophagy., Sato Masahiro;Seki Takahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 24 May 2019, Journal of pharmacological sciences, 140, 2

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice., Matsuzaki Y; Tanaka M; Hakoda S; Masuda T; Miyata R; Konno A; Hirai H, Apr. 2019, Molecular therapy : the journal of the American Society of Gene Therapy, 27, 4, 700, 704

  DOI
• クローズアップ実験法(series 308)　ウイルスベクターの静脈投与によるマウス脳全域への遺伝子導入, ;, Mar. 2019, 37, 4, 581
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Masashi Watanave; Chiaki Hoshino; Ayumu Konno; Yumi Fukuzaki; Yasunori Matsuzaki; Tohru Ishitani; Hirokazu Hirai, Jan. 2019, Neurobiology of disease, 121, 263, 273

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice, Matsuzaki, Yasunori;Tanaka, Masami;Hakoda, Sachiko;Masuda, Tatsuki;Miyata, Ryota;Konno, Ayumu;Hirai, Hirokazu, 2019, MOLECULAR THERAPY, 27, 4, 700, 704

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• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System, Shinohara, Yoichiro;Konno, Ayumu;Nitta, Keisuke;Matsuzaki, Yasunori;Yasui, Hiroyuki;Suwa, Junya;Hiromura, Keiju;Hirai, Hirokazu, 2019, MOLECULAR NEUROBIOLOGY, 56, 6, 4203, 4214

  DOI
• Advanced CUBIC tissue clearing for whole-organ cell profiling, Matsumoto, Katsuhiko;Mitani, Tomoki T.;Horiguchi, Shuhei A.;Kaneshiro, Junichi;Murakami, Tatsuya C.;Mano, Tomoyuki;Fujishima, Hiroshi;Konno, Ayumu;Watanabe, Tomonobu M.;Hirai, Hirokazu;Ueda, Hiroki R., 2019, NATURE PROTOCOLS, 14, 12, 3506, 3537

  DOI
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning., Watanave Masashi;Matsuzaki Yasunori;Nakajima Yasuyo;Ozawa Atsushi;Yamada Masanobu;Hirai Hirokazu, 12 Dec. 2018, Frontiers in cellular neuroscience, 12

  DOI
• d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production., Seki Takahiro;Sato Masahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 19 Oct. 2018, Molecular and cellular neurosciences, 93

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Watanave Masashi;Hoshino Chiaki;Konno Ayumu;Fukuzaki Yumi;Matsuzaki Yasunori;Ishitani Tohru;Hirai Hirokazu, 19 Oct. 2018, Neurobiology of disease, 121

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System., Shinohara Yoichiro;Konno Ayumu;Nitta Keisuke;Matsuzaki Yasunori;Yasui Hiroyuki;Suwa Junya;Hiromura Keiju;Hirai Hirokazu, 05 Oct. 2018, Molecular neurobiology, 56, 6

  DOI
• d-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production., Seki T; Sato M; Konno A; Hirai H; Kurauchi Y; Hisatsune A; Katsuki H, Oct. 2018, Molecular and cellular neurosciences, 93, 36, 47, Scientific journal

  DOI
• Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240., Seki Takahiro;Sato Masahiro;Kibe Yuki;Ohta Tomoko;Oshima Mutsumi;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi, 02 Sep. 2018, Neurobiology of disease, 120

  DOI
• Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240., Seki T; Sato M; Kibe Y; Ohta T; Oshima M; Konno A; Hirai H; Kurauchi Y; Hisatsune A; Katsuki H, Sep. 2018, Neurobiology of disease, 120, 34, 50, Scientific journal

  DOI
• Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements., Gaffield Michael A;Rowan Matthew J M;Amat Samantha B;Hirai Hirokazu;Christie Jason M, 17 Aug. 2018, eLife, 7

  DOI
• マウスCNSにおけるAAV-PHP.Bの中和抗体と遺伝子発現の検討, 篠原 洋一郎; 今野 歩; 諏訪 絢也; 廣村 桂樹; 秋山 英雄; 平井 宏和, Aug. 2018, 68, 3, 211, 212
• モデルマウスを用いた本態性振戦発症機序の解明, ;;;;;;;, Aug. 2018, 68, 3, 211
• Elavl3 is essential for the maintenance of Purkinje neuron axons., Ogawa Yuki;Kakumoto Kyoko;Yoshida Tetsu;Kuwako Ken-Ichiro;Miyazaki Taisuke;Yamaguchi Junji;Konno Ayumu;Hata Junichi;Uchiyama Yasuo;Hirai Hirokazu;Watanabe Masahiko;Darnell Robert B;Okano Hideyuki;Okano Hirotaka James, 09 Feb. 2018, Scientific reports, 8, 1

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Yasunori Matsuzaki; Ayumu Konno; Ryuta Mochizuki; Yoichiro Shinohara; Keisuke Nitta; Yukihiro Okada; Hirokazu Hirai, 05 Feb. 2018, Neuroscience Letters, 665, 182, 188, Scientific journal

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• Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums, Hirokazu Hirai, 01 Feb. 2018, Cerebellum, 17, 1, 23, 27

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• Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders, Hirokazu Hirai; Masanobu Kano, 01 Feb. 2018, Current Opinion in Pharmacology, 38, 51, 58

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• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning., Masashi Watanave; Yasunori Matsuzaki; Yasuyo Nakajima; Atsushi Ozawa; Masanobu Yamada; Hirokazu Hirai, 2018, Frontiers in cellular neuroscience, 12, 490, 490, Scientific journal

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• Viral Vector-Based Evaluation of Regulatory Regions in the Neuron-Specific Enolase (NSE) Promoter in Mouse Cerebellum In Vivo, Yoichiro Shinohara; Toshinori Ohtani; Ayumu Konno; Hirokazu Hirai, Dec. 2017, CEREBELLUM, 16, 5-6, 913, 922, Scientific journal

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• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells, Nobutaka Takahashi; Anton N. Shuvaev; Ayumu Konno; Yasunori Matsuzaki; Masashi Watanave; Hirokazu Hirai, Dec. 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 660, 670, Scientific journal

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• リピート病における神経変性の分子機構解明を目指して　アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, ;;;;;, Dec. 2017, 2017年度, [3PW23
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain., Matsuzaki Yasunori;Konno Ayumu;Mochizuki Ryuta;Shinohara Yoichiro;Nitta Keisuke;Okada Yukihiro;Hirai Hirokazu, 24 Nov. 2017, Neuroscience letters, 665

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• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Keisuke Nitta; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Sep. 2017, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 6, 159, 170, Scientific journal

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• 小脳プルキンエ細胞における古典的Cキナーゼαとγの発現量と生理機能(Expression levels and physiological significance of protein kinase C α and γ in cerebellar Purkinje cells), 平井 宏和, Sep. 2017, 39回・47回, 159
• Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging, Kazuki Harada; Motoki Ito; Xiaowen Wang; Mika Tanaka; Devina Wongso; Ayumu Konno; Hirokazu Hirai; Hajime Hirase; Takashi Tsuboi; Tetsuya Kitaguchi, Aug. 2017, SCIENTIFIC REPORTS, 7, 1, 7351, Scientific journal

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• アデノ随伴ウイルスベクターを用いた神経細胞特異的NSEプロモーターの解析, ;;;, Aug. 2017, 67, 3, 273
• CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously, Tsuyoshi Hattori; Minoru Kaji; Hiroshi Ishii; Roboon Jureepon; Mika Takarada-Iemata; Hieu Minh Ta; Thuong Manh Le; Ayumu Konno; Hirokazu Hirai; Yoshitake Shiraishi; Noriyuki Ozaki; Yasuhiko Yamamoto; Hiroshi Okamoto; Shigeru Yokoyama; Haruhiro Higashida; Yasuko Kitao; Osamu Hori, Jun. 2017, GLIA, 65, 6, 974, 989, Scientific journal

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• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Yasunori Matsuzaki; Ayumu Konno; Ryo Mukai; Fumiaki Honda; Masafumi Hirato; Yuhei Yoshimoto; Hirokazu Hirai, 01 Apr. 2017, Molecular Neurobiology, 54, 3, 1745, 1758, Scientific journal

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• "ニューロン特異的エノラーゼ(NSE)"は炎症があるとニューロンではなくグリア細胞で産生される, 平井 宏和, Apr. 2017, 89, 2, 241
• Caffeine Alleviates Progressive Motor Deficits in a Transgenic Mouse Model of Spinocerebellar Ataxia, Nelio Goncalves; Ana T. Simoes; Rui D. Prediger; Hirokazu Hirai; Rodrigo A. Cunha; Luis Pereira de Almeida, Mar. 2017, ANNALS OF NEUROLOGY, 81, 3, 407, 418, Scientific journal

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• Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice, Anton N. Shuvaev; Nobutake Hosoi; Yamato Sato; Dai Yanagihara; Hirokazu Hirai, Jan. 2017, JOURNAL OF PHYSIOLOGY-LONDON, 595, 1, 141, 164, Scientific journal

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• 【基底核と小脳-その相違と連関】生理機能　小脳の機能, 平井 宏和, Jan. 2017, 35, 1, 28
• Production of the neuron-specific enolase in astrocytes, but not in neurons, under the neuronal inflammation, Hirokazu Hirai, 2017, Seikagaku, 89, 2, 241, 243

  DOI
• Establishment of model mice of spinocerebellar ataxia type 21 using adeno-associated viral vectors, Kibe, Yuki;Seki, Takahiro;Kurauchi, Yuki;Konno, Ayumu;Hirai, Hirokazu;Hisatsune, Akinori;Katsuki, Hiroshi, 2017, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133, 3, S207, S207
• Rapamycin activates mammalian microautophagy, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2017, JOURNAL OF PHARMACOLOGICAL SCIENCES, 133, 3, S245, S245
• FMRP Expression Levels in Mouse Central Nervous System Neurons Determine Behavioral Phenotype, Jason Arsenault; Shervin Gholizadeh; Yosuke Niibori; Laura K. Pacey; Sebok K. Halder; Enea Koxhioni; Ayumu Konno; Hirokazu Hirai; David R. Hampson, Dec. 2016, HUMAN GENE THERAPY, 27, 12, 982, 996, Scientific journal

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• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Mamiko Suzuki; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry K. Y. Chan; Hirokazu Hirai, Nov. 2016, PLOS ONE, 11, 11, e0164202, Scientific journal

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• Adaptive Local Thresholding for Co-Localization Detection in Multi-Channel Fluorescence Microscopic Images, Eisuke Ito; Yusuke Tomaru; Akira Iizuka; Hirokazu Hirai; Tsuyoshi Kato, Nov. 2016, IEICE TRANSACTIONS ON INFORMATION AND SYSTEMS, E99D, 11, 2851, 2855, Scientific journal

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• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains., Shinohara Yoichiro;Konno Ayumu;Takahashi Nobutaka;Matsuzaki Yasunori;Kishi Shoji;Hirai Hirokazu, 29 Aug. 2016, PloS one, 11, 8

  DOI
• A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors, Hiroo Takahashi; Yoichi Ogawa; Sei-ichi Yoshihara; Ryo Asahina; Masahito Kinoshita; Tatsuro Kitano; Michiko Kitsuki; Kana Tatsumi; Mamiko Okuda; Kouko Tatsumi; Akio Wanaka; Hirokazu Hirai; Peter L. Stern; Akio Tsuboi, Aug. 2016, JOURNAL OF NEUROSCIENCE, 36, 31, 8210, 8227, Scientific journal

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Yoichiro Shinohara; Ayumu Konno; Nobutaka Takahashi; Yasunori Matsuzaki; Shoji Kishi; Hirokazu Hirai, Aug. 2016, PLOS ONE, 11, 8, e0162023, Scientific journal

  DOI
• Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice, Nana Suto; Tokue Mieda; Akira Iizuka; Kazuhiro Nakamura; Hirokazu Hirai, Aug. 2016, CNS NEUROSCIENCE & THERAPEUTICS, 22, 8, 670, 676, Scientific journal

  DOI
• Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells, Masahiro Sato; Takahiro Seki; Ayumu Konno; Hirokazu Hirai; Yuki Kurauchi; Akinori Hisatsune; Hiroshi Katsuki, Aug. 2016, GENES TO CELLS, 21, 8, 861, 873, Scientific journal

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• 神経炎症により神経細胞特異的NSEプロモーター活性が神経細胞からグリア細胞へと可逆的に変化する, ;;;, Aug. 2016, 66, 3, 245
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Akira Iizuka; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Jul. 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889, Scientific journal

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• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Toshihiro Yanai; Aya Kurosawa; Yoshiaki Nikaido; Nozomi Nakajima; Tamio Saito; Hiroyuki Osada; Ayumu Konno; Hirokazu Hirai; Shigeki Takeda, Jul. 2016, GENES TO CELLS, 21, 7, 717, 727, Scientific journal

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• 私はなぜ研究医を目指したか　文部科学省GPプログラムや他の取組みの検証　群馬大学「卒前・卒後一貫MD-PhDコース」を経験して, ;;;;;, Jul. 2016, 47, Suppl., 23
• 神経変性疾患の最前線2016　運動の記憶を形成する細胞内シグナル　脊髄小脳変性症マウスを用いた解析と治療の可能性(Signaling pathway required for motor memory formation: Studies using spinocerebellar ataxia model mice and the therapeutic perspective), ;;, Jul. 2016, 46回, 84
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia., Sawada Yusuke;Konno Ayumu;Nagaoka Jun;Hirai Hirokazu, 13 Jun. 2016, Scientific reports, 6

  DOI
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia, Yusuke Sawada; Ayumu Konno; Jun Nagaoka; Hirokazu Hirai, Jun. 2016, SCIENTIFIC REPORTS, 6, 27758, Scientific journal

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• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain., Yanai Toshihiro;Kurosawa Aya;Nikaido Yoshiaki;Nakajima Nozomi;Saito Tamio;Osada Hiroyuki;Konno Ayumu;Hirai Hirokazu;Takeda Shigeki, 17 May 2016, Genes to cells : devoted to molecular & cellular mechanisms, 21, 7

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• Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice., Suto Nana;Mieda Tokue;Iizuka Akira;Nakamura Kazuhiro;Hirai Hirokazu, 03 May 2016, CNS neuroscience & therapeutics, 22, 8

  DOI
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain., Monai Hiromu;Ohkura Masamichi;Tanaka Mika;Oe Yuki;Konno Ayumu;Hirai Hirokazu;Mikoshiba Katsuhiko;Itohara Shigeyoshi;Nakai Junichi;Iwai Youichi;Hirase Hajime, 22 Mar. 2016, Nature communications, 7

  DOI
• Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles, Mariana Conceição; Liliana Mendonça; Clévio Nóbrega; Célia Gomes; Pedro Costa; Hirokazu Hirai; João Nuno Moreira; Maria C. Lima; N. Manjunath; Luís Pereira de Almeida, 01 Mar. 2016, Data in Brief, 6, 700, 705, Scientific journal

  DOI
• Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype, Mariana Conceicao; Liliana Mendonca; Clevio Nobrega; Celia Gomes; Pedro Costa; Hirokazu Hirai; Joao Nuno Moreira; Maria C. Lima; N. Manjunath; Luis Pereira de Almeida, Mar. 2016, BIOMATERIALS, 82, 124, 137, Scientific journal

  DOI
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain, Hiromu Monai; Masamichi Ohkura; Mika Tanaka; Yuki Oe; Ayumu Konno; Hirokazu Hirai; Katsuhiko Mikoshiba; Shigeyoshi Itohara; Junichi Nakai; Youichi Iwai; Hajime Hirase, Mar. 2016, NATURE COMMUNICATIONS, 7, 11100, Scientific journal

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• Mesenchymal Stem Cells Attenuate Peripheral Neuronal Degeneration in Spinocerebellar Ataxia Type 1 Knockin Mice, Tokue Mieda; Nana Suto; Akira Iizuka; Serina Matsuura; Haku Iizuka; Kenji Takagishi; Kazuhiro Nakamura; Hirokazu Hirai, Mar. 2016, JOURNAL OF NEUROSCIENCE RESEARCH, 94, 3, 246, 252, Scientific journal

  DOI
• Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles., Conceição Mariana;Mendonça Liliana;Nóbrega Clévio;Gomes Célia;Costa Pedro;Hirai Hirokazu;Moreira João Nuno;Lima Maria C;Manjunath N;de Almeida Luís Pereira, 20 Jan. 2016, Data in brief, 6

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• Experience of mGluR1 gene therapy in transgenic models of SCA1 mice, Anton N. Shuvaev; H. Hirai, 2016, Sovremennye Tehnologii v Medicine, 8, 4, 143, 156, Scientific journal

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• Mesenchymal Stem Cells Attenuate Peripheral Neuronal Degeneration in Spinocerebellar Ataxia Type 1 Knockin Mice, Mieda, Tokue;Suto, Nana;Iizuka, Akira;Matsuura, Serina;Iizuka, Haku;Takagishi, Kenji;Nakamura, Kazuhiro;Hirai, Hirokazu, 2016, JOURNAL OF NEUROSCIENCE RESEARCH, 94, 3, 246, 252

  DOI
• Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype, Conceicao, Mariana;Mendonca, Liliana;Nobrega, Clevio;Gomes, Celia;Costa, Pedro;Hirai, Hirokazu;Moreira, Joao Nuno;Lima, Maria C.;Manjunath, N.;de Almeida, Luis Pereira, 2016, BIOMATERIALS, 82, 124, 137

  DOI
• Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain, Monai, Hiromu;Ohkura, Masamichi;Tanaka, Mika;Oe, Yuki;Konno, Ayumu;Hirai, Hirokazu;Mikoshiba, Katsuhiko;Itohara, Shigeyoshi;Nakai, Junichi;Iwai, Youichi;Hirase, Hajime, 2016, NATURE COMMUNICATIONS, 7

  DOI
• Inflammation-induced reversible switch of the neuron-specific enolase promoter from Purkinje neurons to Bergmann glia, Sawada, Yusuke;Konno, Ayumu;Nagaoka, Jun;Hirai, Hirokazu, 2016, SCIENTIFIC REPORTS, 6

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Yanai, Toshihiro;Kurosawa, Aya;Nikaido, Yoshiaki;Nakajima, Nozomi;Saito, Tamio;Osada, Hiroyuki;Konno, Ayumu;Hirai, Hirokazu;Takeda, Shigeki, 2016, GENES TO CELLS, 21, 7, 717, 727

  DOI
• Fluorescent-based evaluation of chaperone-mediated autophagy and microautophagy activities in cultured cells, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, GENES TO CELLS, 21, 8, 861, 873

  DOI
• Morphological and Functional Attenuation of Degeneration of Peripheral Neurons by Mesenchymal Stem Cell-Conditioned Medium in Spinocerebellar Ataxia Type 1-Knock-in Mice, Suto, Nana;Mieda, Tokue;Iizuka, Akira;Nakamura, Kazuhiro;Hirai, Hirokazu, 2016, CNS NEUROSCIENCE & THERAPEUTICS, 22, 8, 670, 676

  DOI
• A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors, Takahashi, Hiroo;Ogawa, Yoichi;Yoshihara, Sei-ichi;Asahina, Ryo;Kinoshita, Masahito;Kitano, Tatsuro;Kitsuki, Michiko;Tatsumi, Kana;Okuda, Mamiko;Tatsumi, Kouko;Wanaka, Akio;Hirai, Hirokazu;Stern, Peter L.;Tsuboi, Akio, 2016, JOURNAL OF NEUROSCIENCE, 36, 31, 8210, 8227

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Iizuka, Akira;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Shinohara, Yoichiro;Konno, Ayumu;Takahashi, Nobutaka;Matsuzaki, Yasunori;Kishi, Shoji;Hirai, Hirokazu, 2016, PLOS ONE, 11, 8

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Suzuki, Mamiko;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry K. Y.;Hirai, Hirokazu, 2016, PLOS ONE, 11, 11

  DOI
• Effect of mutant TMEM240 that causes spinocerebellar ataxia 21 on neural morphology, Seki, Takahiro;Sato, Masahiro;Kibe, Yuki;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130, 3, S104, S104
• Visualization of microautophagy and chaperone-mediated autophagy in primary cultured neurons, Sato, Masahiro;Seki, Takahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2016, JOURNAL OF PHARMACOLOGICAL SCIENCES, 130, 3, S192, S192
• Mesenchymal stem cells attenuate peripheral neuronal degeneration in spinocerebellar ataxia type 1 knockin mice., Mieda Tokue;Suto Nana;Iizuka Akira;Matsuura Serina;Iizuka Haku;Takagishi Kenji;Nakamura Kazuhiro;Hirai Hirokazu, 28 Dec. 2015, Journal of neuroscience research, 94, 3

  DOI
• Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype., Conceição Mariana;Mendonça Liliana;Nóbrega Clévio;Gomes Célia;Costa Pedro;Hirai Hirokazu;Moreira João Nuno;Lima Maria C;Manjunath N;Pereira de Almeida Luís, 21 Dec. 2015, Biomaterials, 82

  DOI
• A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance., Ageta-Ishihara Natsumi;Yamazaki Maya;Konno Kohtarou;Nakayama Hisako;Abe Manabu;Hashimoto Kenji;Nishioka Tomoki;Kaibuchi Kozo;Hattori Satoko;Miyakawa Tsuyoshi;Tanaka Kohichi;Huda Fathul;Hirai Hirokazu;Hashimoto Kouichi;Watanabe Masahiko;Sakimura Kenji;Kinoshita Makoto, 10 Dec. 2015, Nature communications, 6

  DOI
• A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance, Natsumi Ageta-Ishihara; Maya Yamazaki; Kohtarou Konno; Hisako Nakayama; Manabu Abe; Kenji Hashimoto; Tomoki Nishioka; Kozo Kaibuchi; Satoko Hattori; Tsuyoshi Miyakawa; Kohichi Tanaka; Fathul Huda; Hirokazu Hirai; Kouichi Hashimoto; Masahiko Watanabe; Kenji Sakimura; Makoto Kinoshita, Dec. 2015, NATURE COMMUNICATIONS, 6, 10090, Scientific journal

  DOI
• Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease, Clevio Nobrega; Sara Carmo-Silva; David Albuquerque; Ana Vasconcelos-Ferreira; Udaya-Geetha Vijayakumar; Liliana Mendonca; Hirokazu Hirai; Luis Pereira de Almeida, Dec. 2015, BRAIN, 138, Pt 12, 3537, 3554, Scientific journal

  DOI
• Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease., Nóbrega Clévio;Carmo-Silva Sara;Albuquerque David;Vasconcelos-Ferreira Ana;Vijayakumar Udaya-Geetha;Mendonça Liliana;Hirai Hirokazu;de Almeida Luís Pereira, 21 Oct. 2015, Brain : a journal of neurology, 138, Pt 12

  DOI
• Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease, Joana Duarte-Neves; Nélio Gonçalves; Janete Cunha-Santos; Ana Teresa Simões; Wilfred F.A. den Dunnen; Hirokazu Hirai; Sebastian Kügler; Clãudia Cavadas; Luĩs Pereira de Almeida, 01 Oct. 2015, Human Molecular Genetics, 24, 19, 5451, 5463, Scientific journal

  DOI
• Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease., Duarte-Neves Joana;Gonçalves Nélio;Cunha-Santos Janete;Simões Ana Teresa;den Dunnen Wilfred F A;Hirai Hirokazu;Kügler Sebastian;Cavadas Cláudia;Pereira de Almeida Luís, 27 Jul. 2015, Human molecular genetics, 24, 19

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα., Iizuka Akira;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 30 Jun. 2015, Brain structure & function, 221, 6

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Shinya Kusakari; Fumihito Saitow; Yukio Ago; Koji Shibasaki; Miho Sato-Hashimoto; Yasunori Matsuzaki; Takenori Kotani; Yoji Murata; Hirokazu Hirai; Toshio Matsuda; Hidenori Suzuki; Takashi Matozaki; Hiroshi Ohnishi, May 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572, Scientific journal

  DOI
• Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice, Akira Iizuka; Kazuhiro Nakamura; Hirokazu Hirai, Apr. 2015, NEUROSCIENCE LETTERS, 592, 37, 41, Scientific journal

  DOI
• Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia, Kazuhiro Nakamura; Tokue Mieda; Nana Suto; Serina Matsuura; Hirokazu Hirai, Apr. 2015, CEREBELLUM, 14, 2, 165, 170

  DOI
• Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice., Iizuka Akira;Nakamura Kazuhiro;Hirai Hirokazu, 25 Feb. 2015, Neuroscience letters, 592

  DOI
• Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice., Kusakari Shinya;Saitow Fumihito;Ago Yukio;Shibasaki Koji;Sato-Hashimoto Miho;Matsuzaki Yasunori;Kotani Takenori;Murata Yoji;Hirai Hirokazu;Matsuda Toshio;Suzuki Hidenori;Matozaki Takashi;Ohnishi Hiroshi, 23 Feb. 2015, Molecular and cellular biology, 35, 9

  DOI
• Retrograde Signaling for Climbing Fiber Synapse Elimination, Naofumi Uesaka; Motokazu Uchigashima; Takayasu Mikuni; Hirokazu Hirai; Masahiko Watanabe; Masanobu Kano, Feb. 2015, CEREBELLUM, 14, 1, 4, 7, Scientific journal

  DOI
• Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice, Liliana S. Mendonca; Clevio Nobrega; Hirokazu Hirai; Brian K. Kaspar; Luis Pereira de Almeida, Feb. 2015, BRAIN, 138, Pt 2, 320, 335, Scientific journal

  DOI
• Identification and characterization of PKCP gamma, a kinase associated with SCA14, as an amyloidogenic protein, Hideyuki Takahashi; Naoko Adachi; Toshihiko Shirafuji; Sally Danno; Takehiko Ueyama; Michele Vendruscolo; Anton N. Shuvaev; Takuya Sugimoto; Takahiro Seki; Daizo Hamada; Kazuhiro Irie; Hirokazu Hirai; Norio Sakai; Naoaki Saito, Jan. 2015, HUMAN MOLECULAR GENETICS, 24, 2, 525, 539, Scientific journal

  DOI
• Retrograde Signaling for Climbing Fiber Synapse Elimination, Uesaka, Naofumi;Uchigashima, Motokazu;Mikuni, Takayasu;Hirai, Hirokazu;Watanabe, Masahiko;Kano, Masanobu, 2015, CEREBELLUM, 14, 1, 4, 7

  DOI
• Identification and characterization of PKCP gamma, a kinase associated with SCA14, as an amyloidogenic protein, Takahashi, Hideyuki;Adachi, Naoko;Shirafuji, Toshihiko;Danno, Sally;Ueyama, Takehiko;Vendruscolo, Michele;Shuvaev, Anton N.;Sugimoto, Takuya;Seki, Takahiro;Hamada, Daizo;Irie, Kazuhiro;Hirai, Hirokazu;Sakai, Norio;Saito, Naoaki, 2015, HUMAN MOLECULAR GENETICS, 24, 2, 525, 539

  DOI
• Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice, Mendonca, Liliana S.;Nobrega, Clevio;Hirai, Hirokazu;Kaspar, Brian K.;de Almeida, Luis Pereira, 2015, BRAIN, 138, 320, 335

  DOI
• Mesenchymal Stem Cells as a Potential Therapeutic Tool for Spinocerebellar Ataxia, Nakamura, Kazuhiro;Mieda, Tokue;Suto, Nana;Matsuura, Serina;Hirai, Hirokazu, 2015, CEREBELLUM, 14, 2, 165, 170

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Kusakari, Shinya;Saitow, Fumihito;Ago, Yukio;Shibasaki, Koji;Sato-Hashimoto, Miho;Matsuzaki, Yasunori;Kotani, Takenori;Murata, Yoji;Hirai, Hirokazu;Matsuda, Toshio;Suzuki, Hidenori;Matozaki, Takashi;Ohnishi, Hiroshi, 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572

  DOI
• Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice, Iizuka, Akira;Nakamura, Kazuhiro;Hirai, Hirokazu, 2015, NEUROSCIENCE LETTERS, 592, 37, 41

  DOI
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry;Hirai, Hirokazu, 2015, MOLECULAR THERAPY, 23, S237, S237
• Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease, Nobrega, Clevio;Carmo-Silva, Sara;Albuquerque, David;Vasconcelos-Ferreira, Ana;Vijayakumar, Udaya-Geetha;Mendonca, Liliana;Hirai, Hirokazu;de Almeida, Luis Pereira, 2015, BRAIN, 138, 3537, 3554

  DOI
• A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance, Ageta-Ishihara, Natsumi;Yamazaki, Maya;Konno, Kohtarou;Nakayama, Hisako;Abe, Manabu;Hashimoto, Kenji;Nishioka, Tomoki;Kaibuchi, Kozo;Hattori, Satoko;Miyakawa, Tsuyoshi;Tanaka, Kohichi;Huda, Fathul;Hirai, Hirokazu;Hashimoto, Kouichi;Watanabe, Masahiko;Sakimura, Kenji;Kinoshita, Makoto, 2015, NATURE COMMUNICATIONS, 6

  DOI
• Exercise Differentially Affects Cerebellar Cytotoxic Microglia in Spinocerebellar Ataxia Model Mice, Suto Nana;Nakamura Kazuhiro;Hirai Hirokazu, 2015, The Kitakanto Medical Journal, 65, 1, 123, 124
• Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice., Mendonça Liliana S;Nóbrega Clévio;Hirai Hirokazu;Kaspar Brian K;Pereira de Almeida Luís, 19 Dec. 2014, Brain : a journal of neurology, 138, Pt 2

  DOI
• Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein., Takahashi Hideyuki;Adachi Naoko;Shirafuji Toshihiko;Danno Sally;Ueyama Takehiko;Vendruscolo Michele;Shuvaev Anton N;Sugimoto Takuya;Seki Takahiro;Hamada Daizo;Irie Kazuhiro;Hirai Hirokazu;Sakai Norio;Saito Naoaki, 12 Sep. 2014, Human molecular genetics, 24, 2

  DOI
• One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice., Saida H; Matsuzaki Y; Takayama K; Iizuka A; Konno A; Yanagi S; Hirai H, Sep. 2014, Gene therapy, 21, 9, 820, 827

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model., Huda Fathul;Konno Ayumu;Matsuzaki Yasunori;Goenawan Hanna;Miyake Koichi;Shimada Takashi;Hirai Hirokazu, 06 Aug. 2014, Molecular therapy. Methods & clinical development, 1

  DOI
• Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons, Sei-ichi Yoshihara; Hiroo Takahashi; Nobushiro Nishimura; Masahito Kinoshita; Ryo Asahina; Michiko Kitsuki; Kana Tatsumi; Yoko Furukawa-Hibi; Hirokazu Hirai; Taku Nagai; Kiyofumi Yamada; Akio Tsuboi, Aug. 2014, CELL REPORTS, 8, 3, 843, 857, Scientific journal

  DOI
• Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons., Yoshihara Sei-Ichi;Takahashi Hiroo;Nishimura Nobushiro;Kinoshita Masahito;Asahina Ryo;Kitsuki Michiko;Tatsumi Kana;Furukawa-Hibi Yoko;Hirai Hirokazu;Nagai Taku;Yamada Kiyofumi;Tsuboi Akio, 31 Jul. 2014, Cell reports, 8, 3

  DOI
• Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue, Noriyuki Okonogi; Kazuhiro Nakamura; Yoshiyuki Suzuki; Nana Suto; Kazutomo Suzue; Takuya Kaminuma; Takashi Nakano; Hirokazu Hirai, Jul. 2014, JOURNAL OF RADIATION RESEARCH, 55, 4, 713, 719, Scientific journal

  DOI
• Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1, Serina Matsuura; Anton N. Shuvaev; Akira Iizuka; Kazuhiro Nakamura; Hirokazu Hirai, Jun. 2014, CEREBELLUM, 13, 3, 323, 330, Scientific journal

  DOI
• Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain., Uesaka Naofumi;Uchigashima Motokazu;Mikuni Takayasu;Nakazawa Takanobu;Nakao Harumi;Hirai Hirokazu;Aiba Atsu;Watanabe Masahiko;Kano Masanobu, 15 May 2014, Science (New York, N.Y.), 344, 6187

  DOI
• Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain, Naofumi Uesaka; Motokazu Uchigashima; Takayasu Mikuni; Takanobu Nakazawa; Harumi Nakao; Hirokazu Hirai; Atsu Aiba; Masahiko Watanabe; Masanobu Kano, May 2014, SCIENCE, 344, 6187, 1020, 1023, Scientific journal

  DOI
• Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue., Okonogi Noriyuki;Nakamura Kazuhiro;Suzuki Yoshiyuki;Suto Nana;Suzue Kazutomo;Kaminuma Takuya;Nakano Takashi;Hirai Hirokazu, 04 Apr. 2014, Journal of radiation research, 55, 4

  DOI
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter, Yasunori Matsuzaki; Miho Oue; Hirokazu Hirai, Feb. 2014, JOURNAL OF NEUROSCIENCE METHODS, 223, 133, 143, Scientific journal

  DOI
• Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells, Ayumu Konno; Anton N. Shuvaev; Noriko Miyake; Koichi Miyake; Akira Iizuka; Serina Matsuura; Fathul Huda; Kazuhiro Nakamura; Shigeru Yanagi; Takashi Shimada; Hirokazu Hirai, Feb. 2014, CEREBELLUM, 13, 1, 29, 41, Scientific journal

  DOI
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells, Tomohiko Irie; Yasunori Matsuzaki; Yuko Sekino; Hirokazu Hirai, Jan. 2014, JOURNAL OF PHYSIOLOGY-LONDON, 592, 1, 229, 247, Scientific journal

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Fathul Huda; Ayumu Konno; Yasunori Matsuzaki; Hanna Goenawan; Koichi Miyake; Takashi Shimada; Hirokazu Hirai, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1, 14032, Scientific journal

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Huda, Fathul;Konno, Ayumu;Matsuzaki, Yasunori;Goenawan, Hanna;Miyake, Koichi;Shimada, Takashi;Hirai, Hirokazu, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1

  DOI
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells, Irie, Tomohiko;Matsuzaki, Yasunori;Sekino, Yuko;Hirai, Hirokazu, 2014, JOURNAL OF PHYSIOLOGY-LONDON, 592, 1, 229, 247

  DOI
• Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells, Konno, Ayumu;Shuvaev, Anton N.;Miyake, Noriko;Miyake, Koichi;Iizuka, Akira;Matsuura, Serina;Huda, Fathul;Nakamura, Kazuhiro;Yanagi, Shigeru;Shimada, Takashi;Hirai, Hirokazu, 2014, CEREBELLUM, 13, 1, 29, 41

  DOI
• Mesenchymal Stem Cells Ameliorate Cerebellar Pathology in a Mouse Model of Spinocerebellar Ataxia Type 1, Matsuura, Serina;Shuvaev, Anton N.;Iizuka, Akira;Nakamura, Kazuhiro;Hirai, Hirokazu, 2014, CEREBELLUM, 13, 3, 323, 330

  DOI
• Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain, Uesaka, Naofumi;Uchigashima, Motokazu;Mikuni, Takayasu;Nakazawa, Takanobu;Nakao, Harumi;Hirai, Hirokazu;Aiba, Atsu;Watanabe, Masahiko;Kano, Masanobu, 2014, SCIENCE, 344, 6187, 1020, 1023

  DOI
• Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue, Okonogi, Noriyuki;Nakamura, Kazuhiro;Suzuki, Yoshiyuki;Suto, Nana;Suzue, Kazutomo;Kaminuma, Takuya;Nakano, Takashi;Hirai, Hirokazu, 2014, JOURNAL OF RADIATION RESEARCH, 55, 4, 713, 719

  DOI
• RESCUE OF DEGENERATING NEURONS IN THE CEREBELLUM BY LENTIVIRAL VECTOR-BASED GENE TRANSFER, Hirai, Hirokazu, 2014, JOURNAL OF GENE MEDICINE, 16, 7-8, 243, 244
• Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons, Yoshihara, Sei-ichi;Takahashi, Hiroo;Nishimura, Nobushiro;Kinoshita, Masahito;Asahina, Ryo;Kitsuki, Michiko;Tatsumi, Kana;Furukawa-Hibi, Yoko;Hirai, Hirokazu;Nagai, Taku;Yamada, Kiyofumi;Tsuboi, Akio, 2014, CELL REPORTS, 8, 3, 843, 857

  DOI
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells., Irie Tomohiko;Matsuzaki Yasunori;Sekino Yuko;Hirai Hirokazu, 11 Nov. 2013, The Journal of physiology, 592, 1

  DOI
• Activity-Dependent Neurotrophin Signaling Underlies Developmental Switch of Ca2+ Channel Subtypes Mediating Neurotransmitter Release, Takafumi Miki; Hirokazu Hirai; Tomoyuki Takahashi, Nov. 2013, JOURNAL OF NEUROSCIENCE, 33, 48, 18755, 18763, Scientific journal

  DOI
• CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice, Shirin Akther; Natalia Korshnova; Jing Zhong; Mingkun Liang; Stanislav M. Cherepanov; Olga Lopatina; Yulia K. Komleva; Alla B. Salmina; Tomoko Nishimura; Azam A. K. M. Fakhrul; Hirokazu Hirai; Ichiro Kato; Yasuhiko Yamamoto; Shin Takasawa; Hiroshi Okamoto; Haruhiro Higashida, Sep. 2013, MOLECULAR BRAIN, 6, 41, Scientific journal

  DOI
• Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease, Isabel Nascimento-Ferreira; Clevio Nobrega; Ana Vasconcelos-Ferreira; Isabel Onofre; David Albuquerque; Celia Aveleira; Hirokazu Hirai; Nicole Deglon; Luis Pereira de Almeida, Jul. 2013, BRAIN, 136, Pt 7, 2173, 2188, Scientific journal

  DOI
• POSTURAL DYSFUNCTION IN A TRANSGENIC MOUSE MODEL OF SPINOCEREBELLAR ATAXIA TYPE 3, H. Yamaura; H. Hirai; D. Yanagihara, Jul. 2013, NEUROSCIENCE, 243, 126, 135, Scientific journal

  DOI
• Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum, Takayasu Mikuni; Naofumi Uesaka; Hiroyuki Okuno; Hirokazu Hirai; Karl Deisseroth; Haruhiko Bito; Masanobu Kano, Jun. 2013, NEURON, 78, 6, 1024, 1035, Scientific journal

  DOI
• Impairment of spinal motor neurons in spinocerebellar ataxia type 1-knock-in mice, Yasuhiko Takechi; Tokue Mieda; Akira Iizuka; Syutaro Toya; Nana Suto; Kenji Takagishi; Yoichi Nakazato; Kazuhiro Nakamura; Hirokazu Hirai, 22 Feb. 2013, Neuroscience Letters, 535, 1, 67, 72, Scientific journal

  DOI
• Displays of paternal mouse pup retrieval following communicative interaction with maternal mates, Hong-Xiang Liu; Olga Lopatina; Chiharu Higashida; Hiroko Fujimoto; Shirin Akther; Alena Inzhutova; Mingkun Liang; Jing Zhong; Takahiro Tsuji; Toru Yoshihara; Kohei Sumi; Mizuho Ishiyama; Wen-Jie Ma; Mitsunori Ozaki; Satoshi Yagitani; Shigeru Yokoyama; Naofumi Mukaida; Takeshi Sakurai; Osamu Hori; Katsuji Yoshioka; Atsushi Hirao; Yukio Kato; Katsuhiko Ishihara; Ichiro Kato; Hiroshi Okamoto; Stanislav M. Cherepanov; Alla B. Salmina; Hirokazu Hirai; Masahide Asano; David A. Brown; Isamu Nagano; Haruhiro Higashida, Jan. 2013, NATURE COMMUNICATIONS, 4, 1346, Scientific journal

  DOI
• Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice, Clevio Nobrega; Isabel Nascimento-Ferreira; Isabel Onofre; David Albuquerque; Hirokazu Hirai; Nicole Deglon; Luis Pereira de Almeida, Jan. 2013, PLOS ONE, 8, 1, e52396, Scientific journal

  DOI
• Exercise differentially affects cerebellar cytotoxic microglia in spinocerebellar ataxia model mice, Nana Suto; Kazuhiro Nakamura; Hirokazu Hirai, 2013, Kitakanto Medical Journal, 63, 3, 209, 215, Scientific journal

  DOI
• Silencing Mutant Ataxin-3 Rescues Motor Deficits and Neuropathology in Machado-Joseph Disease Transgenic Mice, Nobrega, Clevio;Nascimento-Ferreira, Isabel;Onofre, Isabel;Albuquerque, David;Hirai, Hirokazu;Deglon, Nicole;de Almeida, Luis Pereira, 2013, PLOS ONE, 8, 1

  DOI
• Impairment of spinal motor neurons in spinocerebellar Ataxia type 1-knock-in mice, Takechi, Yasuhiko;Mieda, Tokue;Iizuka, Akira;Toya, Syutaro;Suto, Nana;Takagishi, Kenji;Nakazato, Yoichi;Nakamura, Kazuhiro;Hirai, Hirokazu, 2013, NEUROSCIENCE LETTERS, 535, 67, 72

  DOI
• Displays of paternal mouse pup retrieval following communicative interaction with maternal mates, Liu, Hong-Xiang;Lopatina, Olga;Higashida, Chiharu;Fujimoto, Hiroko;Akther, Shirin;Inzhutova, Alena;Liang, Mingkun;Zhong, Jing;Tsuji, Takahiro;Yoshihara, Toru;Sumi, Kohei;Ishiyama, Mizuho;Ma, Wen-Jie;Ozaki, Mitsunori;Yagitani, Satoshi;Yokoyama, Shigeru;Mukaida, Naofumi;Sakurai, Takeshi;Hori, Osamu;Yoshioka, Katsuji;Hirao, Atsushi;Kato, Yukio;Ishihara, Katsuhiko;Kato, Ichiro;Okamoto, Hiroshi;Cherepanov, Stanislav M.;Salmina, Alla B.;Hirai, Hirokazu;Asano, Masahide;Brown, David A.;Nagano, Isamu;Higashida, Haruhiro, 2013, NATURE COMMUNICATIONS, 4

  DOI
• Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum, Mikuni, Takayasu;Uesaka, Naofumi;Okuno, Hiroyuki;Hirai, Hirokazu;Deisseroth, Karl;Bito, Haruhiko;Kano, Masanobu, 2013, NEURON, 78, 6, 1024, 1035

  DOI
• Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease, Nascimento-Ferreira, Isabel;Nobrega, Clevio;Vasconcelos-Ferreira, Ana;Onofre, Isabel;Albuquerque, David;Aveleira, Celia;Hirai, Hirokazu;Deglon, Nicole;de Almeida, Luis Pereira, 2013, BRAIN, 136, 2173, 2188

  DOI
• Virus-mediated highly efficient and cell-type specific gene expression in the cerebellum-Modulation of cathepsin K activity and development of unique promoters-, Hirai, Hirokazu, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S40, S40
• CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice, Akther, Shirin;Korshnova, Natalia;Zhong, Jing;Liang, Mingkun;Cherepanov, Stanislav M.;Lopatina, Olga;Komleva, Yulia K.;Salmina, Alla B.;Nishimura, Tomoko;Fakhrul, Azam A. K. M.;Hirai, Hirokazu;Kato, Ichiro;Yamamoto, Yasuhiko;Takasawa, Shin;Okamoto, Hiroshi;Higashida, Haruhiro, 2013, MOLECULAR BRAIN, 6

  DOI
• Activity-Dependent Neurotrophin Signaling Underlies Developmental Switch of Ca2+ Channel Subtypes Mediating Neurotransmitter Release, Miki, Takafumi;Hirai, Hirokazu;Takahashi, Tomoyuki, 2013, JOURNAL OF NEUROSCIENCE, 33, 48, 18755, 18763

  DOI
• Exercise Differentially Affects Cerebellar Cytotoxic Microglia in Spinocerebellar Ataxia Model Mice, Suto Nana;Nakamura Kazuhiro;Hirai Hirokazu, 2013, The Kitakanto Medical Journal, 63, 3, 209, 215
• Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K, Hanna Goenawan; Hirokazu Hirai, Dec. 2012, JOURNAL OF NEUROVIROLOGY, 18, 6, 521, 531, Scientific journal

  DOI
• Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice, Duo Jin; Shin-ichi Muramatsu; Nobuaki Shimizu; Shigeru Yokoyama; Hirokazu Hirai; Kiyofumi Yamada; Hong-Xiang Liu; Chiharu Higashida; Minako Hashii; Akihiko Higashida; Masahide Asano; Shoji Ohkuma; Haruhiro Higashida, Nov. 2012, NEUROCHEMISTRY INTERNATIONAL, 61, 6, 907, 912, Scientific journal

  DOI
• The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice, Miho Oue; Hiroshi Handa; Yasunori Matsuzaki; Kazutomo Suzue; Hirokazu Murakami; Hirokazu Hirai, Nov. 2012, PLOS ONE, 7, 11, e51015, Scientific journal

  DOI
• Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K., Goenawan Hanna;Hirai Hirokazu, 16 Oct. 2012, Journal of neurovirology, 18, 6

  DOI
• Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain, Naofumi Uesaka; Takayasu Mikuni; Kouichi Hashimoto; Hirokazu Hirai; Kenji Sakimura; Masanobu Kano, Aug. 2012, JOURNAL OF NEUROSCIENCE, 32, 34, 11657, 11670, Scientific journal

  DOI
• Basic Research on Cerebellar Gene Therapy Using Lentiviral Vectors, Hirokazu Hirai, Jun. 2012, CEREBELLUM, 11, 2, 443, 445, Scientific journal

  DOI
• 5T4 Glycoprotein Regulates the Sensory Input-Dependent Development of a Specific Subtype of Newborn Interneurons in the Mouse Olfactory Bulb, Sei-ichi Yoshihara; Hiroo Takahashi; Nobushiro Nishimura; Hiromi Naritsuka; Taichi Shirao; Hirokazu Hirai; Yoshihiro Yoshihara; Kensaku Mori; Peter L. Stern; Akio Tsuboi, Feb. 2012, JOURNAL OF NEUROSCIENCE, 32, 6, 2217, 2226, Scientific journal

  DOI
• 5T4 Glycoprotein Regulates the Sensory Input-Dependent Development of a Specific Subtype of Newborn Interneurons in the Mouse Olfactory Bulb, Yoshihara, Sei-ichi;Takahashi, Hiroo;Nishimura, Nobushiro;Naritsuka, Hiromi;Shirao, Taichi;Hirai, Hirokazu;Yoshihara, Yoshihiro;Mori, Kensaku;Stern, Peter L.;Tsuboi, Akio, 2012, JOURNAL OF NEUROSCIENCE, 32, 6, 2217, 2226

  DOI
• Basic Research on Cerebellar Gene Therapy Using Lentiviral Vectors, Hirai, Hirokazu, 2012, CEREBELLUM, 11, 2, 443, 445

  DOI
• Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain, Uesaka, Naofumi;Mikuni, Takayasu;Hashimoto, Kouichi;Hirai, Hirokazu;Sakimura, Kenji;Kano, Masanobu, 2012, JOURNAL OF NEUROSCIENCE, 32, 34, 11657, 11670

  DOI
• Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice, Jin, Duo;Muramatsu, Shin-ichi;Shimizu, Nobuaki;Yokoyama, Shigeru;Hirai, Hirokazu;Yamada, Kiyofumi;Liu, Hong-Xiang;Higashida, Chiharu;Hashii, Minako;Higashida, Akihiko;Asano, Masahide;Ohkuma, Shoji;Higashida, Haruhiro, 2012, NEUROCHEMISTRY INTERNATIONAL, 61, 6, 907, 912

  DOI
• Mutant PKC gamma in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo, Anton N. Shuvaev; Hajime Horiuchi; Takahiro Seki; Hanna Goenawan; Tomohiko Irie; Akira Iizuka; Norio Sakai; Hirokazu Hirai, Oct. 2011, JOURNAL OF NEUROSCIENCE, 31, 40, 14324, 14334, Scientific journal

  DOI
• Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice, Kazuhiro Mitsumura; Nobutake Hosoi; Nobuhiko Furuya; Hirokazu Hirai, Jul. 2011, JOURNAL OF PHYSIOLOGY-LONDON, 589, 13, 3191, 3209, Scientific journal

  DOI
• Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice., Mitsumura Kazuhiro;Hosoi Nobutake;Furuya Nobuhiko;Hirai Hirokazu, 09 May 2011, The Journal of physiology, 589, Pt 13

  DOI
• Disruption of metabotropic glutamate receptor signalling is a major defect at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice, Mitsumura, Kazuhiro;Hosoi, Nobutake;Furuya, Nobuhiko;Hirai, Hirokazu, 2011, JOURNAL OF PHYSIOLOGY-LONDON, 589, 13, 3191, 3209

  DOI
• Mutant PKC gamma in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo, Shuvaev, Anton N.;Horiuchi, Hajime;Seki, Takahiro;Goenawan, Hanna;Irie, Tomohiko;Iizuka, Akira;Sakai, Norio;Hirai, Hirokazu, 2011, JOURNAL OF NEUROSCIENCE, 31, 40, 14324, 14334

  DOI
• Disruption of climbing fiber synapse elimination and LTD expression in cerebellar Purkinje cells by mutant gamma PKC found in spinocerebellar ataxia type 14, Hirai, Hirokazu;Anton, Shuvaev;Seki, Takahiro;Sakai, Norio, 2011, NEUROSCIENCE RESEARCH, 71, E57, E57

  DOI
• Impairment of mGluR signaling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice, Hosoi, Nobutake;Mitsumura, Kazuhiro;Hirai, Hirokazu, 2011, NEUROSCIENCE RESEARCH, 71, E246, E246

  DOI
• Mutant gamma PKC found in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo, Shuvaev, Anton Nikolaevich;Horiuchi, Hajime;Seki, Takahiro;Hanna, Gennawan;Irie, Tomohiko;Iizuka, Akira;Sakai, Norio;Hirai, Hirokazu, 2011, NEUROSCIENCE RESEARCH, 71, E291, E292

  DOI
• High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells In Vivo, Yusuke Sawada; Go Kajiwara; Akira Iizuka; Kiyohiko Takayama; Anton N. Shuvaev; Chiho Koyama; Hirokazu Hirai, Sep. 2010, CEREBELLUM, 9, 3, 291, 302, Scientific journal

  DOI
• レンチウイルスベクターの作製方法とその応用(D.ウイルスの組織細胞化学への応用), 平井 宏和, Jul. 2010, 2008, 93, 99
• Two genetic variants of CD38 in subjects with autism spectrum disorder and controls, Toshio Munesue; Shigeru Yokoyama; Kazuhiko Nakamura; Ayyappan Anitha; Kazuo Yamada; Kenshi Hayashi; Tomoya Asaka; Hong-Xiang Liu; Duo Jin; Keita Koizumi; Mohammad Saharul Islam; Jian-Jun Huang; Wen-Jie Ma; Uh-Hyun Kim; Sun-Jun Kim; Keunwan Park; Dongsup Kim; Mitsuru Kikuchi; Yasuki Ono; Hideo Nakatani; Shiro Suda; Taishi Miyachi; Hirokazu Hirai; Alla Salmina; Yu A. Pichugina; Andrei A. Soumarokov; Nori Takei; Norio Mori; Masatsugu Tsujii; Toshiro Sugiyama; Kunimasa Yagi; Masakazu Yamagishi; Tsukasa Sasaki; Hidenori Yamasue; Nobumasa Kato; Ryota Hashimoto; Masako Taniike; Yutaka Hayashi; Junichiro Hamada; Shioto Suzuki; Akishi Ooi; Mami Noda; Yuko Kamiyama; Mizuho A. Kido; Olga Lopatina; Minako Hashii; Sarwat Amina; Fabio Malavasi; Eric J. Huang; Jiasheng Zhang; Nobuaki Shimizu; Takeo Yoshikawa; Akihiro Matsushima; Yoshio Minabe; Haruhiro Higashida, Jun. 2010, NEUROSCIENCE RESEARCH, 67, 2, 181, 191, Scientific journal

  DOI
• The PtdIns(3,4)P-2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death, Junko Sasaki; Satoshi Kofuji; Reietsu Itoh; Toshihiko Momiyama; Kiyohiko Takayama; Haruka Murakami; Shinsuke Chida; Yuko Tsuya; Shunsuke Takasuga; Satoshi Eguchi; Ken Asanuma; Yasuo Horie; Kouichi Miura; Elizabeth Michele Davies; Christina Mitchell; Masakazu Yamazaki; Hirokazu Hirai; Tadaomi Takenawa; Akira Suzuki; Takehiko Sasaki, May 2010, NATURE, 465, 7297, 497, U127, Scientific journal

  DOI
• Study of cerebellar development and regeneration, using the lentiviral vector, Hirai, Hirokazu;Sawada, Yusuke;Kajiwara, Go, 2010, NEUROSCIENCE RESEARCH, 68, E140, E140

  DOI
• The PtdIns(3,4)P-2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death, Sasaki, Junko;Kofuji, Satoshi;Itoh, Reietsu;Momiyama, Toshihiko;Takayama, Kiyohiko;Murakami, Haruka;Chida, Shinsuke;Tsuya, Yuko;Takasuga, Shunsuke;Eguchi, Satoshi;Asanuma, Ken;Horie, Yasuo;Miura, Kouichi;Davies, Elizabeth Michele;Mitchell, Christina;Yamazaki, Masakazu;Hirai, Hirokazu;Takenawa, Tadaomi;Suzuki, Akira;Sasaki, Takehiko, 2010, NATURE, 465, 7297, 497, U127

  DOI
• A PKC gamma mutation in spinocerebellar ataxia type 14 impairs PKC functions in a dominant-negative manner in cerebellar Purkinje cells in vivo, Shuvaev, Anton;Irie, Tomohiko;Horiuchi, Hajime;Iiduka, Akira;Iino, Masae;Seki, Takahiro;Sakai, Norio;Hirai, Hirokazu, 2010, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S110, S110
• Two genetic variants of CD38 in subjects with autism spectrum disorder and controls, Munesue, Toshio;Yokoyama, Shigeru;Nakamura, Kazuhiko;Anitha, Ayyappan;Yamada, Kazuo;Hayashi, Kenshi;Asaka, Tomoya;Liu, Hong-Xiang;Jin, Duo;Koizumi, Keita;Islam, Mohammad Saharul;Huang, Jian-Jun;Ma, Wen-Jie;Kim, Uh-Hyun;Kim, Sun-Jun;Park, Keunwan;Kim, Dongsup;Kikuchi, Mitsuru;Ono, Yasuki;Nakatani, Hideo;Suda, Shiro;Miyachi, Taishi;Hirai, Hirokazu;Salmina, Alla;Pichugina, Yu A.;Soumarokov, Andrei A.;Takei, Nori;Mori, Norio;Tsujii, Masatsugu;Sugiyama, Toshiro;Yagi, Kunimasa;Yamagishi, Masakazu;Sasaki, Tsukasa;Yamasue, Hidenori;Kato, Nobumasa;Hashimoto, Ryota;Taniike, Masako;Hayashi, Yutaka;Hamada, Junichiro;Suzuki, Shioto;Ooi, Akishi;Noda, Mami;Kamiyama, Yuko;Kido, Mizuho A.;Lopatina, Olga;Hashii, Minako;Amina, Sarwat;Malavasi, Fabio;Huang, Eric J.;Zhang, Jiasheng;Shimizu, Nobuaki;Yoshikawa, Takeo;Matsushima, Akihiro;Minabe, Yoshio;Higashida, Haruhiro, 2010, NEUROSCIENCE RESEARCH, 67, 2, 181, 191

  DOI
• レンチウイルスベクターを用いた運動失調マウスの機能回復 (助成研究報告), 平井 宏和, Aug. 2009, 25, 75, 77
• Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases, Kazuhiro Shiba; Takashi Torashima; Hirokazu Hirai; Kazuma Ogawa; Nasima Akhter; Kenichi Nakajima; Seigo Kinuya; Hirofumi Mori, Feb. 2009, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 29, 2, 434, 440, Scientific journal

  DOI
• Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels, Toru Kobayashi; Hirokazu Hirai; Masae Iino; Ichiro Fuse; Kazuhiro Mitsumura; Kazuo Washiyama; Shinya Kasai; Kazutaka Ikeda, Feb. 2009, NEUROPHARMACOLOGY, 56, 2, 499, 506, Scientific journal

  DOI
• Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells, Miho Oue; Kazuhiro Mitsumura; Takashi Torashima; Chiho Koyama; Haruyasu Yamaguchi; Nobuhiko Furuya; Hirokazu Hirai, Feb. 2009, BRAIN RESEARCH, 1255, 9, 17, Scientific journal

  DOI
• Rescue of abnormal phenotypes in delta 2 glutamate receptor-deficient mice by the extracellular N-terminal and intracellular C-terminal domains of the delta 2 glutamate receptor, Torashima, T; Iizuka, A; Horiuchi, H; Mitsumura, K; Yamasaki, M; Koyama, C; Takayama, K; Iino, M; Watanabe, M; Hirai, H, 2009, European Journal of Neuroscience, 30, 3, 355, 365

  DOI
• Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice, Iizuka, A; Takayama, K; Torashima, T; Yamasaki, M; Koyama, C; Mitsumura, K; Watanabe, M; Hirai, H, 2009, Neurobiology of Disease, 35, 3, 457, 465

  DOI
• Potential usefulness of D2R reporter gene imaging by IBF as gene therapy monitoring for cerebellar neurodegenerative diseases, Shiba, Kazuhiro;Torashima, Takashi;Hirai, Hirokazu;Ogawa, Kazuma;Akhter, Nasima;Nakajima, Kenichi;Kinuya, Seigo;Mori, Hirofumi, 2009, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 29, 2, 434, 440

  DOI
• Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels, Kobayashi, Toru;Hirai, Hirokazu;Iino, Masae;Fuse, Ichiro;Mitsumura, Kazuhiro;Washiyama, Kazuo;Kasai, Shinya;Ikeda, Kazutaka, 2009, NEUROPHARMACOLOGY, 56, 2, 499, 506

  DOI
• RESCUE OF ABNORMAL PHENOTYPES IN delta 2 GLUTAMATE-RECEPTOR-NULL MICE BY THE EXTRACELLULAR N-TERMINAL DOMAIN, Torashima, Takashi;Iizuka, Akira;Horiuchi, Hajime;Mitsumura, Kazuhiro;Yamazaki, Miwako;Koyama, Chiho;Takayama, Kiyohiko;Iino, Masae;Watanabe, Masahiko;Hirai, Hirokazu, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 134, 134
• A PKC gamma MUTATIONS IN SPINOCEREBELLAR TAXIA TYPE 14 IMPAIRS PKC FUNCTIONS IN CEREBELLAR PURKINJE CELLS IN VIVO, Shuvaev, Anton Nikolaevich;Hirai, Hirokazu;Sakai, Norio;Seki, Takahiro;Iino, Masae;Horiuchi, Hajime, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 138, 138
• Progress of the delta 2 glutamate receptor research from the viewpoint of functional domains, Hirai, Hirokazu;Torashima, Takashi;Iizuka, Akira, 2009, NEUROSCIENCE RESEARCH, 65, S9, S9

  DOI
• Influence of lentiviral vector infection on the development of cerebellar Purkinje cells in vivo, Sawada, Yusuke;Kajiwara, Go;Torashima, Takashi;Takayama, Kiyohiko;Horiuchi, Hajime;Iizuka, Akira;Mitsumura, Kazuhiro;Hirai, Hirokazu, 2009, NEUROSCIENCE RESEARCH, 65, S89, S90

  DOI
• Lentiviral vector-mediated rescue of motor behavior in hereditary ataxic mice, Iizuka, Akira;Torashima, Takashi;Mitsumura, Kazuhiro;Koyama, Chiho;Iino, Masae;Hirai, Hirokazu, 2009, NEUROSCIENCE RESEARCH, 65, S96, S96

  DOI
• A PKC gamma mutation in spinocerebellar ataxia type 14 impairs PKC functions in a dominant-negative manner in cerebellar Purkinje cells in vivo, Shuvaev, Anton;Horiuchi, Hajime;Iizuka, Akira;Irie, Tomohiko;Iino, Masae;Seki, Takahiro;Sakai, Norio;Hirai, Hirokazu, 2009, NEUROSCIENCE RESEARCH, 65, S247, S247

  DOI
• The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling, Tokiharu Sato; Takashi Torashima; Kazushi Sugihara; Hirokazu Hirai; Masahide Asano; Katsuji Yoshioka, Nov. 2008, MOLECULAR AND CELLULAR NEUROSCIENCE, 39, 4, 569, 578, Scientific journal

  DOI
• Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors, Hirokazu Hirai, Sep. 2008, CEREBELLUM, 7, 3, 273, 278, Scientific journal

  DOI
• Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter, Kiyohiko Takayama; Takashi Torashima; Hajime Horiuchi; Hirokazu Hirai, Sep. 2008, NEUROSCIENCE LETTERS, 443, 1, 7, 11, Scientific journal

  DOI
• A large form of secretogranin III functions as a sorting receptor for chromogranin a aggregates in PC12 cells, Lu Han; Masayuki Suda; Keisuke Tsuzuki; Rong Wang; Yoshihide Ohe; Hirokazu Hirai; Tsuyoshi Watanabe; Toshiyuki Takeuchi; Masahiro Hosaka, Aug. 2008, MOLECULAR ENDOCRINOLOGY, 22, 8, 1935, 1949, Scientific journal

  DOI
• 群馬大学医学部と生体調節研究所 (大学紹介), 平井 宏和;北村 忠弘, Aug. 2008, 24, 118, 119
• Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter., Takayama Kiyohiko;Torashima Takashi;Horiuchi Hajime;Hirai Hirokazu, 25 Jul. 2008, Neuroscience letters, 443, 1

  DOI
• A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells., Han Lu;Suda Masayuki;Tsuzuki Keisuke;Wang Rong;Ohe Yoshihide;Hirai Hirokazu;Watanabe Tsuyoshi;Takeuchi Toshiyuki;Hosaka Masahiro, 15 May 2008, Molecular endocrinology (Baltimore, Md.), 22, 8

  DOI
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia, Takashi Torashima; Chiho Koyama; Akira Iizuka; Kazuhiro Mitsumura; Kiyohiko Takayama; Shigeru Yanagi; Miho Oue; Haruyasu Yamaguchi; Hirokazu Hirai, Apr. 2008, EMBO REPORTS, 9, 4, 393, 399, Scientific journal

  DOI
• Gene therapy enhancing the ubiquitin-proteasome pathway in a mouse model of polyglutamine disease, Hirai, Hirokazu;Torashima, Takashi;Koyama, Chiho;Yanagi, Shigeru;Ooue, Miho;Yamaguchi, Haruyasu, 2008, JOURNAL OF GENE MEDICINE, 10, 4, 464, 464
• A large form of secretogranin III functions as a sorting receptor for chromogranin a aggregates in PC12 cells, Han, Lu;Suda, Masayuki;Tsuzuki, Keisuke;Wang, Rong;Ohe, Yoshihide;Hirai, Hirokazu;Watanabe, Tsuyoshi;Takeuchi, Toshiyuki;Hosaka, Masahiro, 2008, MOLECULAR ENDOCRINOLOGY, 22, 8, 1935, 1949

  DOI
• The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling, Sato, Tokiharu;Torashima, Takashi;Sugihara, Kazushi;Hirai, Hirokazu;Asano, Masahide;Yoshioka, Katsuji, 2008, MOLECULAR AND CELLULAR NEUROSCIENCE, 39, 4, 569, 578

  DOI
• Recent advances in lentiviral vectors-The application to exploring pathophysiology in the CNS and gene therapy against brain disorders, Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S9, S9
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of polyglutannine disease by enhancing the ubiquitin-proteasome pathway, Torashima, Takashi;Yamaguchi, Haruyasu;Yanagi, Shigeru;Koyama, Chiho;Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S125, S125
• Lentivector-mediated expression of mutant ataxin-3 in mouse cerebellar nucleie, Horiuchi, Hajime;Torashima, Takashi;Takayama, Kiyohiko;Iizuka, Akira;Mitsumura, Kazuhiro;Iino, Masae;Koyama, Chiho;Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S125, S125
• Lentivector-mediated rescue of abnormal phenotype in mice lacking delta 2 glutamate receptors upon expression of the N-terminal domain, Iizuka, Akira;Mistumura, Kazuhiro;Iino, Masae;Torashima, Tkashi;Koyama, Chiho;Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S148, S148
• Immunoelectronmicroscopic analysis of the inclusions in Purkinje cells of a mouse model of spinocerebellar ataxia, Oue, Mine;Torashima, Takashi;Yamaguchi, Haruyasu;Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S205, S205
• Purkinje-cell-selective expression of GFP by lentivectors with the MSCV promoter, Takayama, Kiyohiko;Torashima, Takashi;Horiuchi, Hajime;Hirai, Hirokazu, 2008, NEUROSCIENCE RESEARCH, 61, S278, S278
• Lentiviral-Vector-Mediated Genetherapy for the Spinocerebellar Ataxia, Hirai Hirokazu, 2008, The Kitakanto Medical Journal, 58, 3, 325, 326
• 「子育て」「他者の認識と記憶」に必要な膜タンパク質CD38（第54回北関東医学会総会抄録 特別講演）, 平井 宏和, Aug. 2007, The Kitakanto medical journal, 57, 3, 288, 288
• CD3 and immunoglobulin G Fc receptor regulate cerebellar functions, Kazuhiro Nakamura; Hirokazu Hirai; Takashi Torashima; Taisuke Miyazaki; Hiromichi Tsurui; Yan Xiu; Mareki Ohtsuji; Qing Shun Lin; Kazuyuki Tsukamoto; Hiroyuki Nishimura; Masao Ono; Masahiko Watanabe; Sachiko Hirose, Jul. 2007, MOLECULAR AND CELLULAR BIOLOGY, 27, 14, 5128, 5134, Scientific journal

  DOI
• CD38 is critical for social behaviour by regulating oxytocin secretion, Duo Jin; Hong-Xiang Liu; Hirokazu Hirai; Takashi Torashima; Taku Nagai; Olga Lopatina; Natalia A. Shnayder; Kiyofumi Yamada; Mami Noda; Toshihiro Seike; Kyota Fujita; Shin Takasawa; Shigeru Yokoyama; Keita Koizumi; Yoshitake Shiraishi; Shigenori Tanaka; Minako Hashii; Toru Yoshihara; Kazuhiro Higashida; Mohammad Saharul Islam; Nobuaki Yamada; Kenshi Hayashi; Naoya Noguchi; Ichiro Kato; Hiroshi Okamoto; Akihiro Matsushima; Alla Salmina; Toshio Munesue; Nobuaki Shimizu; Sumiko Mochida; Masahide Asano; Haruhiro Higashida, Mar. 2007, NATURE, 446, 7131, 41, 45, Scientific journal

  DOI
• Ca2+ permeability of the channel pore is not essential for the delta 2 glutamate receptor to regulate synaptic plasticity and motor coordination, Wataru Kakegawa; Taisuke Miyazaki; Hirokazu Hirai; Junko Motohashi; Masayoshi Mishina; Masahiko Watanabe; Michisuke Yuzaki, Mar. 2007, JOURNAL OF PHYSIOLOGY-LONDON, 579, 3, 729, 735, Scientific journal

  DOI
• PROFILE, 平井 宏和, Feb. 2007, 69, 2, 71, 72
• Ca2+ permeability of the channel pore is not essential for the delta 2 glutamate receptor to regulate synaptic plasticity and motor coordination, Kakegawa, Wataru;Miyazaki, Taisuke;Hirai, Hirokazu;Motohashi, Junko;Mishina, Masayoshi;Watanabe, Masahiko;Yuzaki, Michisuke, 2007, JOURNAL OF PHYSIOLOGY-LONDON, 579, 3, 729, 735

  DOI
• Lentiviral-vector-mediated gene rescue - Functional recovery by region-specific expression of CD38 gene, Hirai, Hirokazu;Torashima, Takashi;Jin, Duo;Liu, Hong-Xiang;Lopatina, Olga;Noda, Mami;Hirashidaa, Haruhiro, 2007, NEUROSCIENCE RESEARCH, 58, S68, S68
• Inositol 1,4,5-trisphosphate receptor type-1 in granule cells, not in Purkinje cells, regulates the dendritic morphology of Purkinje cells through brain-derived neurotrophic factor production, Chihiro Hisatsune; Yukiko Kuroda; Takumi Akagi; Takashi Torashima; Hirokazu Hirai; Tsutomu Hashikawa; Takafumi Inoue; Katsuhiko Mikoshiba, Oct. 2006, JOURNAL OF NEUROSCIENCE, 26, 42, 10916, 10924, Scientific journal

  DOI
• Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia, Takashi Torashima; Nobuaki Yamada; Masae Itoh; Akitsugu Yamamoto; Hirokazu Hirai, Jul. 2006, EUROPEAN JOURNAL OF NEUROSCIENCE, 24, 2, 371, 380, Scientific journal

  DOI
• Association between diastolic blood pressure and lower hemoglobin A1C and frontal brain atrophy in elderly subjects with diabetes mellitus, T Sakurai; M Kuranaga; T Takata; K Yamasaki; H Hirai; H Endo; K Yokono, Jun. 2006, JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 54, 6, 1005, 1007

  DOI
• In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors, T Torashima; S Okoyama; T Nishizaki; H Hirai, Apr. 2006, BRAIN RESEARCH, 1082, 1, 11, 22, Scientific journal

  DOI
• A novel GTPase, CRAG, mediates promyelocytic leukemia protein - associated nuclear body formation and degradation of expanded polyglutamine protein, QY Qin; R Inatome; A Hotta; M Kojima; H Yamamura; H Hirai; T Yoshizawa; H Tanaka; K Fukami; S Yanagi, Feb. 2006, JOURNAL OF CELL BIOLOGY, 172, 4, 497, 504, Scientific journal

  DOI
• Cbln1 is essential for synaptic integrity and plasticity in the cerebellum, H Hirai; Z Pang; DH Bao; T Miyazaki; LY Li; E Miura; J Parris; YQ Rong; M Watanabe; M Yuzaki; JI Morgan, Nov. 2005, NATURE NEUROSCIENCE, 8, 11, 1534, 1541, Scientific journal

  DOI
• Rescue of abnormal phenotypes of the delta 2 glutamate receptor-null mice by mutant delta 2 transgenes, H Hirai; T Miyazaki; W Kakegawa; S Matsuda; M Mushina; M Watanabe; M Yuzaki, Jan. 2005, EMBO REPORTS, 6, 1, 90, 95, Scientific journal

  DOI
• IP3 type1受容体を介したPurkinje細胞樹状突起伸展の制御(Implication of IP3R1-mediated signaling in the dendritic outgrowth of Purkinje cells), Hisatsune Chihiro; Kuroda Yukiko; Torashima Takashi; Hirai Hirokazu; Inoue Takafumi; Mikoshiba Katsuhiko, Aug. 2004, 生化学, 76, 8, 862, 862
• New role of delta 2-glutamate receptors in AMPA receptor trafficking and cerebellar function, H Hirai; T Launey; S Mikawa; T Torashima; D Yanagihara; T Kasaura; A Miyamoto; M Yuzaki, Aug. 2003, NATURE NEUROSCIENCE, 6, 8, 869, 876, Scientific journal

  DOI
• Antibody against a putative ligand-binding site reveals delta2 glutamate receptor function, H Hirai; T Launey; S Mikawa; D Yanagihara; T Kasaura; A Miyamoto; M Yuzaki, 2002, CREBELLUM: RECENT DEVELOPMENTS IN CEREBELLAR RESEARCH, 978, 519, 519, Scientific journal

  DOI
• Ca2+-dependent regulation of synaptic delta 2 glutamate receptor density in cultured rat Purkinje neurons, H Hirai, Jul. 2001, EUROPEAN JOURNAL OF NEUROSCIENCE, 14, 1, 73, 82, Scientific journal

  DOI
• Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity, H Hirai, Mar. 2001, NEUROSCIENCE RESEARCH, 39, 3, 261, 267, Scientific journal

  DOI
• The regulatory connection between the activity of granule cell NMDA receptors and dendritic differentiation of cerebellar Purkinje cells, H Hirai; T Launey, Jul. 2000, JOURNAL OF NEUROSCIENCE, 20, 14, 5217, 5224, Scientific journal
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons, S Matsuda; T Launey; S Mikawa; H Hirai, Jun. 2000, EMBO JOURNAL, 19, 12, 2765, 2774, Scientific journal

  DOI
• A simple method using P-31-NMR spectroscopy for the study of protein phosphorylation, H Hirai; K Yoshioka; K Yamada, Apr. 2000, BRAIN RESEARCH PROTOCOLS, 5, 2, 182, 189, Scientific journal

  DOI
• Clustering of delta glutamate receptors is regulated by the actin cytoskeleton in the dendritic spines of cultured rat Purkinje cells, H Hirai, Feb. 2000, EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 2, 563, 570, Scientific journal

  DOI
• Regulation of phosphatidylcholine biosynthesis by mGluR1 alpha expressed in human embryonic kidney 293 cells - A P-31-NMR study, H Hirai; K Yoshioka; K Yamada, Dec. 1999, MOLECULAR AND CELLULAR NEUROSCIENCE, 14, 6, 444, 454, Scientific journal

  DOI
• Phosphorylation of serine-880 in GluR2 by protein kinase C prevents its C terminus from binding with glutamate receptor-interacting protein, S Matsuda; S Mikawa; H Hirai, Oct. 1999, JOURNAL OF NEUROCHEMISTRY, 73, 4, 1765, 1768, Scientific journal

  DOI
• Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells, H Hirai; S Matsuda, Sep. 1999, NEUROSCIENCE RESEARCH, 34, 4, 281, 287, Scientific journal

  DOI
• The clustering of NMDA receptor NR1 subunit is regulated by the interaction between the C-terminal exon cassettes and the cytoskeleton, S Matsuda; H Hirai, Aug. 1999, NEUROSCIENCE RESEARCH, 34, 3, 157, 163, Scientific journal

  DOI
• Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit, B Laube; H Hirai; M Sturgess; H Betz; J Kuhse, Mar. 1997, NEURON, 18, 3, 493, 503, Scientific journal

  DOI
• The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: Identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region, H Hirai; J Kirsch; B Laube; H Betz; J Kuhse, Jun. 1996, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93, 12, 6031, 6036, Scientific journal

  DOI
• Gabaergic system modulates the formation of LTP (longterm potentiation) in the superior colliculus, Y Okada; H Hirai, 1996, GABA: RECEPTORS, TRANSPORTERS AND METABOLISM, 209, 220, International conference proceedings
• ADENOSINE FACILITATES IN-VIVO NEUROTRANSMISSION IN THE SUPERIOR COLLICULUS OF THE RAT, H HIRAI; Y OKADA, Sep. 1995, JOURNAL OF NEUROPHYSIOLOGY, 74, 3, 950, 960, Scientific journal
• LONG-TERM POTENTIATION OF NEUROTRANSMISSION IN THE INFERIOR COLLICULUS OF THE RAT, H HOSOMI; H HIRAI; Y OKADA; M AMATSU, Aug. 1995, NEUROSCIENCE LETTERS, 195, 3, 175, 178, Scientific journal

  DOI
• THE RELEASE OF GLUTAMATE AND ACCUMULATION OF INTRACELLULAR CALCIUM IN THE GUINEA-PIG HIPPOCAMPAL SLICES DURING GLUCOSE DEPRIVATION, T TAKATA; H HIRAI; T SHIGEMOTO; Y OKADA, Apr. 1995, NEUROSCIENCE LETTERS, 189, 1, 21, 24, Scientific journal

  DOI
• ADENOSINE ENHANCES NEURONAL DAMAGE DURING DEPRIVATION OF OXYGEN AND GLUCOSE IN GUINEA-PIG SUPERIOR COLLICULAR SLICES, F FUJIWARA; H HIRAI; N TAMAKI; Y OKADA, Dec. 1994, NEUROSCIENCE LETTERS, 182, 2, 283, 286, Scientific journal

  DOI
• TOLUENE INHIBITS SYNAPTIC TRANSMISSION WITHOUT CAUSING GROSS MORPHOLOGICAL DISTURBANCES, Y IKEUCHI; H HIRAI, Nov. 1994, BRAIN RESEARCH, 664, 1-2, 266, 270

  DOI
• THE CONTRIBUTION OF PKA TO THE EXCITATORY MECHANISM OF ADENOSINE IN GUINEA-PIG SUPERIOR COLLICULUS SLICES, H HIRAI; Y IKEUCHI; Y OKADA, Nov. 1994, NEUROSCIENCE LETTERS, 182, 1, 33, 36, Scientific journal

  DOI
• EXOGENOUSLY APPLIED GANGLIOSIDES (GM(1), GD(1A) AND G(MIX)) FAIL TO FACILITATE THE INDUCTION OF LONG-TERM POTENTIATION (LTP) IN THE SLICES OF HIPPOCAMPUS AND SUPERIOR COLLICULUS OF THE GUINEA-PIG, Y OKADA; H RAHMANN; H HIRAI; A TERASHIMA, Apr. 1994, NEUROSCIENCE LETTERS, 170, 2, 269, 272, Scientific journal

  DOI
• ADENOSINE FACILITATES GLUTAMATE RELEASE IN A PROTEIN KINASE-DEPENDENT MANNER IN SUPERIOR COLLICULUS SLICES, H HIRAI; Y OKADA, Apr. 1994, EUROPEAN JOURNAL OF PHARMACOLOGY, 256, 1, 65, 71, Scientific journal

  DOI
• IPSILATERAL CORTICOTECTAL PATHWAY INHIBITS THE FORMATION OF LONG-TERM POTENTIATION (LTP) IN THE RAT SUPERIOR COLLICULUS THROUGH GABAERGIC MECHANISM, H HIRAI; Y OKADA, Nov. 1993, BRAIN RESEARCH, 629, 1, 23, 30, Scientific journal

  DOI
• EXCITATORY AND INHIBITORY EFFECTS OF TOLUENE ON NEURAL ACTIVITY IN GUINEA-PIG HIPPOCAMPAL SLICES, Y IKEUCHI; H HIRAI; Y OKADA; T MIO; T MATSUDA, Aug. 1993, NEUROSCIENCE LETTERS, 158, 1, 63, 66, Scientific journal

  DOI
• SERINE RELEASED FROM HIPPOCAMPAL SLICES DURING DEPRIVATION OF OXYGEN AND GLUCOSE ENHANCES THE EFFECTS OF GLUTAMATE ON NEURONAL FUNCTION, H HIRAI; Y OKADA, May 1993, NEUROSCIENCE, 54, 1, 61, 67, Scientific journal

  DOI
• INHIBITORY EFFECT OF GABA (GAMMA-AMINOBUTYRIC-ACID) ON THE INDUCTION OF LONG-TERM POTENTIATION IN GUINEA-PIG SUPERIOR COLLICULUS SLICES, H HIRAI; H TOMITA; Y OKADA, Jan. 1993, NEUROSCIENCE LETTERS, 149, 2, 198, 200, Scientific journal

  DOI
• MRI of chronic toluene intoxication, H. Hirai; Y. Ikeuchi, 1993, Clinical Neurology, 33, 5, 552, 555, Scientific journal
• Quantitative analysis of sodium fast and slow component in in vivo human brain tissue using MR Na image, H. Hirai; K. Yamasaki; H. Kidena; M. Kono, 1992, Kakuigaku, 29, 12, 1447, 1454, Scientific journal
• Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors., Hirai Hirokazu, Cerebellum (London, England), 7, 3

  DOI
• High transgene expression by lentiviral vectors causes maldevelopment of Purkinje cells in vivo., Sawada Yusuke;Kajiwara Go;Iizuka Akira;Takayama Kiyohiko;Shuvaev Anton N;Koyama Chiho;Hirai Hirokazu, Cerebellum (London, England), 9, 3

  DOI
• Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo., Shuvaev Anton N;Horiuchi Hajime;Seki Takahiro;Goenawan Hanna;Irie Tomohiko;Iizuka Akira;Sakai Norio;Hirai Hirokazu, The Journal of neuroscience : the official journal of the Society for Neuroscience, 31, 40

  DOI
• Basic research on cerebellar gene therapy using lentiviral vectors., Hirai Hirokazu, Cerebellum (London, England), 11, 2

  DOI
• Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells., Konno Ayumu;Shuvaev Anton N;Miyake Noriko;Miyake Koichi;Iizuka Akira;Matsuura Serina;Huda Fathul;Nakamura Kazuhiro;Yanagi Shigeru;Shimada Takashi;Hirai Hirokazu, Cerebellum (London, England), 13, 1

  DOI
• Mesenchymal stem cells ameliorate cerebellar pathology in a mouse model of spinocerebellar ataxia type 1., Matsuura Serina;Shuvaev Anton N;Iizuka Akira;Nakamura Kazuhiro;Hirai Hirokazu, Cerebellum (London, England), 13, 3

  DOI
• Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release., Miki Takafumi;Hirai Hirokazu;Takahashi Tomoyuki, The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 48

  DOI
• Mesenchymal stem cells as a potential therapeutic tool for spinocerebellar ataxia., Nakamura Kazuhiro;Mieda Tokue;Suto Nana;Matsuura Serina;Hirai Hirokazu, Cerebellum (London, England), 14, 2

  DOI
• A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors., Takahashi Hiroo;Ogawa Yoichi;Yoshihara Sei-Ichi;Asahina Ryo;Kinoshita Masahito;Kitano Tatsuro;Kitsuki Michiko;Tatsumi Kana;Okuda Mamiko;Tatsumi Kouko;Wanaka Akio;Hirai Hirokazu;Stern Peter L;Tsuboi Akio, The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 31

  DOI
• Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums., Hirai Hirokazu, Cerebellum (London, England), 17, 1

  DOI
• Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?, Cendelin Jan;Buffo Annalisa;Hirai Hirokazu;Magrassi Lorenzo;Mitoma Hiroshi;Sherrard Rachel;Vozeh Frantisek;Manto Mario, Cerebellum (London, England), 18, 3

  DOI
• CD3 and immunoglobulin G Fc receptor regulate cerebellar functions, Nakamura, Kazuhiro;Hirai, Hirokazu;Torashima, Takashi;Miyazaki, Taisuke;Tsurui, Hiromichi;Xiu, Yan;Ohtsuji, Mareki;Lin, Qing Shun;Tsukamoto, Kazuyuki;Nishimura, Hiroyuki;Ono, Masao;Watanabe, Masahiko;Hirose, Sachiko, 2007, MOLECULAR AND CELLULAR BIOLOGY, 27, 14, 5128, 5134

  DOI
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia, Torashima, Takashi;Koyama, Chiho;Iizuka, Akira;Mitsumura, Kazuhiro;Takayama, Kiyohiko;Yanagi, Shigeru;Oue, Miho;Yamaguchi, Haruyasu;Hirai, Hirokazu, 2008, EMBO REPORTS, 9, 4, 393, 399

  DOI
• Purkinje-cell-preferential transduction by lentiviral vectors with the murine stem cell virus promoter, Takayama, Kiyohiko;Torashima, Takashi;Horiuchi, Hajime;Hirai, Hirokazu, 2008, NEUROSCIENCE LETTERS, 443, 1, 7, 11

  DOI
• Progress in transduction of cerebellar Purkinje cells in vivo using viral vectors, Hirai, Hirokazu, 2008, CEREBELLUM, 7, 3, 273, 278

  DOI
• Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells, Oue, Miho;Mitsumura, Kazuhiro;Torashima, Takashi;Koyama, Chiho;Yamaguchi, Haruyasu;Furuya, Nobuhiko;Hirai, Hirokazu, 2009, BRAIN RESEARCH, 1255, 9, 17

  DOI
• High Transgene Expression by Lentiviral Vectors Causes Maldevelopment of Purkinje Cells In Vivo, Sawada, Yusuke;Kajiwara, Go;Iizuka, Akira;Takayama, Kiyohiko;Shuvaev, Anton N.;Koyama, Chiho;Hirai, Hirokazu, 2010, CEREBELLUM, 9, 3, 291, 302

  DOI
• Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K, Goenawan, Hanna;Hirai, Hirokazu, 2012, JOURNAL OF NEUROVIROLOGY, 18, 6, 521, 531

  DOI
• The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice, Oue, Miho;Handa, Hiroshi;Matsuzaki, Yasunori;Suzue, Kazutomo;Murakami, Hirokazu;Hirai, Hirokazu, 2012, PLOS ONE, 7, 11

  DOI
• Cell-type specific gene transfer in olivo-cerebellar coculture preparation for the study of developmental synapse elimination, Uesaka, Naofumi;Mikuni, Takayasu;Hirai, Hirokazu;Kano, Masanobu, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S40, S40
• Kv3.3 channels harboring a missense mutation of spinocerebellar ataxia type 13 alter neuronal excitability and induce apoptotic cell death in cultured cerebellar Purkinje cells of mice, Irie, Tomohiko;Matsuzaki, Yasunori;Sekino, Yuko;Hirai, Hirokazu, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S244, S244
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter, Matsuzaki, Yasunori;Oue, Miho;Hirai, Hirokazu, 2014, JOURNAL OF NEUROSCIENCE METHODS, 223, 133, 143

  DOI
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning, Watanave, Masashi;Matsuzaki, Yasunori;Nakajima, Yasuyo;Ozawa, Atsushi;Yamada, Masanobu;Hirai, Hirokazu, 2018, FRONTIERS IN CELLULAR NEUROSCIENCE, 12

  DOI
• D-Cysteine promotes dendritic development in primary cultured cerebellar Purkinje cells via hydrogen sulfide production, Seki, Takahiro;Sato, Masahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi, 2018, MOLECULAR AND CELLULAR NEUROSCIENCE, 93, 36, 47

  DOI
• Efficient whole brain transduction by systemic infusion of minimally purified AAV-PHP.eB, Konno, Ayumu;Hirai, Hirokazu, 2020, JOURNAL OF NEUROSCIENCE METHODS, 346

  DOI
• BATTLE: Genetically Engineered Strategies for Split-Tunable Allocation of Multiple Transgenes in the Nervous System, Kohara, Keigo;Inoue, Akitoshi;Nakano, Yousuke;Hirai, Hirokazu;Kobayashi, Takuya;Maruyama, Masato;Baba, Ryosuke;Kawashima, Chiho, 2020, ISCIENCE, 23, 6

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter, Hoshino, Chiaki;Konno, Ayumu;Hosoi, Nobutake;Kaneko, Ryosuke;Mukai, Ryo;Nakai, Junichi;Hirai, Hirokazu, 2021, MOLECULAR BRAIN, 14, 1

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice, Sugimoto, Hisako;Horii, Takuro;Hirota, Jun-Na;Sano, Yoshitake;Shinoda, Yo;Konno, Ayumu;Hirai, Hirokazu;Ishizaki, Yasuki;Hirase, Hajime;Hatada, Izuho;Furuichi, Teiichi;Sadakata, Tetsushi, 2021, MOLECULAR BRAIN, 14, 1

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor a in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia, Yasui, Hiroyuki;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2021, NEUROSCIENCE, 462, 328, 336

  DOI
• Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum, Nagao, Soichi;Hirai, Hirokazu;Kano, Masanobu;Yuzaki, Michisuke, 2021, NEUROSCIENCE, 462, 1, 3

  DOI
• Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1, Shuvaev, Anton N.;Belozor, Olga S.;Mozhei, Oleg;Yakovleva, Dariya A.;Potapenko, Ilya V.;Shuvaev, Andrey N.;Smolnikova, Marina V.;Salmin, Vladimir V.;Salmina, Alla B.;Hirai, Hirokazu;Teschemacher, Anja G.;Kasparov, Sergey, 2021, NEUROBIOLOGY OF DISEASE, 154

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Radhiyanti, Putri T.;Konno, Ayumu;Matsuzaki, Yasunori;Hirai, Hirokazu, 2021, NEUROSCIENCE LETTERS, 756

  DOI
• Therapeutic potential of D-cysteine against in vitro and in vivo models of spinocerebellar ataxia, Ohta, Tomoko;Morikawa, Yuri;Sato, Masahiro;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Hisatsune, Akinori;Katsuki, Hiroshi;Seki, Takahiro, 2021, EXPERIMENTAL NEUROLOGY, 343

  DOI
• Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome, Ohgami, Nobutaka;Iizuka, Akira;Hirai, Hirokazu;Yajima, Ichiro;Iida, Machiko;Shimada, Atsuyoshi;Tsuzuki, Toyonori;Jijiwa, Mayumi;Asai, Naoya;Takahashi, Masahide;Kato, Masashi, 2021, JOURNAL OF BIOLOGICAL CHEMISTRY, 296

  DOI
• Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications, Cendelin, Jan;Cvetanovic, Marija;Gandelman, Mandi;Hirai, Hirokazu;Orr, Harry T.;Pulst, Stefan M.;Strupp, Michael;Tichanek, Filip;Tuma, Jan;Manto, Mario, 2022, CEREBELLUM, 21, 3, 452, 481

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury, Kawakami, Ryo;Matsui, Miki;Konno, Ayumu;Kaneko, Ryosuke;Shrestha, Shreya;Shrestha, Suman;Sunaga, Hiroaki;Hanaoka, Hirofumi;Goto, Sawako;Hosojima, Michihiro;Kabasawa, Hideyuki;Obokata, Masaru;Koitabashi, Norimichi;Matsui, Hiroki;Sasaki, Tsutomu;Saito, Akihiko;Yanagita, Motoko;Hirai, Hirokazu;Kurabayashi, Masahiko;Iso, Tatsuya, 2021, JOURNAL OF PATHOLOGY, 255, 4, 362, 373

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating, Suzuki, Akinobu;Kosugi, Sakurako;Murayama, Emi;Sasakawa, Eri;Ohkawa, Noriaki;Konno, Ayumu;Hirai, Hirokazu;Inokuchi, Kaoru, 2022, NATURE COMMUNICATIONS, 13, 1

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells, Hirai, Hirokazu;Fukai, Yuuki;Konno, Ayumu;Hosoi, Nobutake, 2022, CEREBELLUM, 21, 5, 776, 783

  DOI
• Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain, Sakai, Aya;Yasui, Takeshi;Watanave, Masashi;Tatsumi, Rine;Yamamoto, Yoshihiko;Takano, Wataru;Tani, Yuki;Okamura, Izumi;Hirai, Hirokazu;Takeda, Shigeki, 2022, GENES TO CELLS, 27, 5, 345, 355

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca²⁺-activated large-conductance K⁺ channels and motor coordination, Watanave, Masashi;Takahashi, Nobutaka;Hosoi, Nobutake;Konno, Ayumu;Yamamoto, Hikaru;Yasui, Hiroyuki;Kawachi, Mika;Horii, Takuro;Matsuzaki, Yasunori;Hatada, Izuho;Hirai, Hirokazu, 2022, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, 7

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation, Ueda, Erika;Ohta, Tomoko;Konno, Ayumu;Hirai, Hirokazu;Kurauchi, Yuki;Katsuki, Hiroshi;Seki, Takahiro, 2022, CELLS, 11, 7

  DOI
• The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice, Ninomiya, Ayane;Mshaty, Abdallah;Haijima, Asahi;Yajima, Hiroyuki;Kokubo, Michifumi;Khairinisa, Miski Aghnia;Ariyani, Winda;Fujiwara, Yuki;Ishii, Sumiyasu;Hosoi, Nobutake;Hirai, Hirokazu;Amano, Izuki;Koibuchi, Noriyuki, 2022, FOOD AND CHEMICAL TOXICOLOGY, 159

  DOI
• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice, Inada, Kengo;Hagihara, Mitsue;Tsujimoto, Kazuko;Abe, Takaya;Konno, Ayumu;Hirai, Hirokazu;Kiyonari, Hiroshi;Miyamichi, Kazunari, 2022, NEURON, 110, 12, 2009, +

  DOI
• Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation, Tokuyama, Takeshi;Uosaki, Hideki;Sugiura, Ayumu;Nishitai, Gen;Takeda, Keisuke;Nagashima, Shun;Shiiba, Isshin;Ito, Naoki;Amo, Taku;Mohri, Satoshi;Nishimura, Akiyuki;Nishida, Motohiro;Konno, Ayumu;Hirai, Hirokazu;Ishido, Satoshi;Yoshizawa, Takahiro;Shindo, Takayuki;Takada, Shingo;Kinugawa, Shintaro;Inatome, Ryoko;Yanagi, Shigeru, 2022, ISCIENCE, 25, 7

  DOI
• Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1, Shuvaev, Anton N.;Belozor, Olga S.;Mozhei, Oleg, I;Shuvaev, Andrey N.;Fritsler, Yana, V;Khilazheva, Elena D.;Mosyagina, Angelina, I;Hirai, Hirokazu;Teschemacher, Anja G.;Kasparov, Sergey, 2022, CELLS, 11, 14

  DOI
• Synaptic pruning through glial synapse engulfment upon motor learning, Morizawa, Yosuke M.;Matsumoto, Mami;Nakashima, Yuka;Endo, Narumi;Aida, Tomomi;Ishikane, Hiroshi;Beppu, Kaoru;Moritoh, Satoru;Inada, Hitoshi;Osumi, Noriko;Shigetomi, Eiji;Koizumi, Schuichi;Yang, Guang;Hirai, Hirokazu;Tanaka, Kohichi;Tanaka, Kenji F.;Ohno, Nobuhiko;Fukazawa, Yugo;Matsui, Ko, 2022, NATURE NEUROSCIENCE, 25, 11, 1458, +

  DOI
• Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo, Okada, Yukihiro;Hosoi, Nobutake;Matsuzaki, Yasunori;Fukai, Yuuki;Hiraga, Akito;Nakai, Junichi;Nitta, Keisuke;Shinohara, Yoichiro;Konno, Ayumu;Hirai, Hirokazu, 2022, COMMUNICATIONS BIOLOGY, 5, 1

  DOI
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers, Jin, Mingyue;Matsumoto, Sakiko;Ayaki, Takashi;Yamakado, Hodaka;Taguchi, Tomoyuki;Togawa, Natsuko;Konno, Ayumu;Hirai, Hirokazu;Nakajima, Hiroshi;Komai, Shoji;Ishida, Ryuichi;Chiba, Syuhei;Takahashi, Ryosuke;Takao, Toshifumi;Hirotsune, Shinji, 2022, NATURE COMMUNICATIONS, 13, 1

  DOI
• Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor, Ninomiya, Ayane;Amano, Izuki;Kokubo, Michifumi;Takatsuru, Yusuke;Ishii, Sumiyasu;Hirai, Hirokazu;Hosoi, Nobutake;Koibuchi, Noriyuki, 2022, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, 45

  DOI
• Development and Optimization of a Multilayer Rat Purkinje Neuron Culture, Uggerud, Ida Margrethe;Krakenes, Torbjorn;Hirai, Hirokazu;Vedeler, Christian Alexander;Schubert, Manja, 2023, CEREBELLUM

  DOI
• Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis, Ichinose, Sotaro;Susuki, Yoshihiro;Hosoi, Nobutake;Kaneko, Ryosuke;Ebihara, Mizuho;Hirai, Hirokazu;Iwasaki, Hirohide;Ori-McKenney, Kassandra M., 2023, ELIFE, 12

  DOI
• Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans, Murase, Shuhei;Sakitani, Naoyoshi;Maekawa, Takahiro;Yoshino, Daisuke;Takano, Kouji;Konno, Ayumu;Hirai, Hirokazu;Saito, Taku;Tanaka, Sakae;Shinohara, Keisuke;Kishi, Takuya;Yoshikawa, Yuki;Sakai, Takamasa;Ayaori, Makoto;Inanami, Hirohiko;Tomiyasu, Koji;Takashima, Atsushi;Ogata, Toru;Tsuchimochi, Hirotsugu;Sato, Shinya;Saito, Shigeyoshi;Yoshino, Kohzoh;Matsuura, Yuiko;Funamoto, Kenichi;Ochi, Hiroki;Shinohara, Masahiro;Nagao, Motoshi;Sawada, Yasuhiro, 2023, NATURE BIOMEDICAL ENGINEERING

  DOI
• Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice, Yaguchi, Kasane;Hagihara, Mitsue;Konno, Ayumu;Hirai, Hirokazu;Yukinaga, Hiroko;Miyamichi, Kazunari, 2023, PLOS ONE, 18, 5

  DOI
• A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant, Kawabata, Hayato;Konno, Ayumu;Matsuzaki, Yasunori;Hirai, Hirokazu, 2023, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 29, 81, 92

  DOI
• Astrocytic GPCR-Induced Ca²⁺ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes, Ozawa, Katsuya;Nagao, Masaki;Konno, Ayumu;Iwai, Youichi;Vittani, Marta;Kusk, Peter;Mishima, Tsuneko;Hirai, Hirokazu;Nedergaard, Maiken;Hirase, Hajime, 2023, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 17

  DOI
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia., Torashima Takashi;Koyama Chiho;Iizuka Akira;Mitsumura Kazuhiro;Takayama Kiyohiko;Yanagi Shigeru;Oue Miho;Yamaguchi Haruyasu;Hirai Hirokazu, Mar. 2008, EMBO reports, 9, 4

  DOI
• Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells., Oue Miho;Mitsumura Kazuhiro;Torashima Takashi;Koyama Chiho;Yamaguchi Haruyasu;Furuya Nobuhiko;Hirai Hirokazu, Dec. 2008, Brain research, 1255

  DOI
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, ;;;;;;, Sep. 2019, 92回, [1T14a
• 【小脳研究の未来】病態　遺伝子改変疾患マウスと小脳異常, ;, Feb. 2021, 72, 1, 69
• 小脳機能維持における甲状腺ホルモンの新たな役割の解明　プルキンエ細胞小胞体からのカルシウム放出調節における重要性, ;;;;;;, Apr. 2021, 97, 1, 265
• プルキンエ細胞特異的に発現させた変異甲状腺ホルモン受容体の運動機能調節における作用, ;;;;;, Apr. 2022, 98, 1, 317
• 発現増強因子WPREの短鎖化がマウス脳におけるアデノ随伴ウイルスベクターによる遺伝子発現強度に及ぼす影響, ;;;;, Mar. 2022, 142年会, 28PO7
• 授乳期PFOS曝露による小脳機能の発達異常の体系的解析, ;;;;;;;;;;;;, Jul. 2022, 98, 3, 707
• 変異甲状腺ホルモン受容体を発現させたマウスプルキンエ細胞では、長期抑圧誘発刺激は長期増強を惹起する, ;;;;;;;, May 2023, 99, 1, 286
• The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice., Oue Miho;Handa Hiroshi;Matsuzaki Yasunori;Suzue Kazutomo;Murakami Hirokazu;Hirai Hirokazu, Nov. 2012, PloS one, 7, 11

  DOI
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter., Matsuzaki Yasunori;Oue Miho;Hirai Hirokazu, Dec. 2013, Journal of neuroscience methods, 223

  DOI
• Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System., Inoue Akitoshi;Kobayashi Takuya;Hirai Hirokazu;Kanaya Noriko;Kohara Keigo, Nov. 2020, STAR protocols, 1, 3

  DOI
• Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome., Ohgami Nobutaka;Iizuka Akira;Hirai Hirokazu;Yajima Ichiro;Iida Machiko;Shimada Atsuyoshi;Tsuzuki Toyonori;Jijiwa Mayumi;Asai Naoya;Takahashi Masahide;Kato Masashi, Feb. 2021, The Journal of biological chemistry, 296

  DOI
• GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter., Hoshino Chiaki;Konno Ayumu;Hosoi Nobutake;Kaneko Ryosuke;Mukai Ryo;Nakai Junichi;Hirai Hirokazu, Feb. 2021, Molecular brain, 14, 1

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice., Sugimoto Hisako;Horii Takuro;Hirota Jun-Na;Sano Yoshitake;Shinoda Yo;Konno Ayumu;Hirai Hirokazu;Ishizaki Yasuki;Hirase Hajime;Hatada Izuho;Furuichi Teiichi;Sadakata Tetsushi, Mar. 2021, Molecular brain, 14, 1

  DOI
• Chronic optogenetic stimulation of Bergman glia leads to dysfunction of EAAT1 and Purkinje cell death, mimicking the events caused by expression of pathogenic ataxin-1., Shuvaev Anton N;Belozor Olga S;Mozhei Oleg;Yakovleva Dariya A;Potapenko Ilya V;Shuvaev Andrey N;Smolnikova Marina V;Salmin Vladimir V;Salmina Alla B;Hirai Hirokazu;Teschemacher Anja G;Kasparov Sergey, Mar. 2021, Neurobiology of disease, 154

  DOI
• Masao Ito-A Visionary Neuroscientist with a Passion for the Cerebellum., Nagao Soichi;Hirai Hirokazu;Kano Masanobu;Yuzaki Michisuke, Neuroscience, 462

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB., Radhiyanti Putri T;Konno Ayumu;Matsuzaki Yasunori;Hirai Hirokazu, May 2021, Neuroscience letters, 756

  DOI
• Therapeutic potential of d-cysteine against in vitro and in vivo models of spinocerebellar ataxia., Ohta Tomoko;Morikawa Yuri;Sato Masahiro;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Hisatsune Akinori;Katsuki Hiroshi;Seki Takahiro, Jun. 2021, Experimental neurology, 343

  DOI
• Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury., Kawakami Ryo;Matsui Miki;Konno Ayumu;Kaneko Ryosuke;Shrestha Shreya;Shrestha Suman;Sunaga Hiroaki;Hanaoka Hirofumi;Goto Sawako;Hosojima Michihiro;Kabasawa Hideyuki;Obokata Masaru;Koitabashi Norimichi;Matsui Hiroki;Sasaki Tsutomu;Saito Akihiko;Yanagita Motoko;Hirai Hirokazu;Kurabayashi Masahiko;Iso Tatsuya, Sep. 2021, The Journal of pathology, 255, 4

  DOI
• Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications., Cendelin Jan;Cvetanovic Marija;Gandelman Mandi;Hirai Hirokazu;Orr Harry T;Pulst Stefan M;Strupp Michael;Tichanek Filip;Tuma Jan;Manto Mario, Aug. 2021, Cerebellum (London, England), 21, 3

  DOI
• The neurotoxic effect of lactational PFOS exposure on cerebellar functional development in male mice., Ninomiya Ayane;Mshaty Abdallah;Haijima Asahi;Yajima Hiroyuki;Kokubo Michifumi;Khairinisa Miski Aghnia;Ariyani Winda;Fujiwara Yuki;Ishii Sumiyasu;Hosoi Nobutake;Hirai Hirokazu;Amano Izuki;Koibuchi Noriyuki, Dec. 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 159

  DOI
• A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating., Suzuki Akinobu;Kosugi Sakurako;Murayama Emi;Sasakawa Eri;Ohkawa Noriaki;Konno Ayumu;Hirai Hirokazu;Inokuchi Kaoru, Jan. 2022, Nature communications, 13, 1

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination., Watanave Masashi;Takahashi Nobutaka;Hosoi Nobutake;Konno Ayumu;Yamamoto Hikaru;Yasui Hiroyuki;Kawachi Mika;Horii Takuro;Matsuzaki Yasunori;Hatada Izuho;Hirai Hirokazu, Proceedings of the National Academy of Sciences of the United States of America, 119, 7

  DOI
• Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain., Sakai Aya;Yasui Takeshi;Watanave Masashi;Tatsumi Rine;Yamamoto Yoshihiko;Takano Wataru;Tani Yuki;Okamura Izumi;Hirai Hirokazu;Takeda Shigeki, Mar. 2022, Genes to cells : devoted to molecular & cellular mechanisms, 27, 5

  DOI
• Electrophysiological and Imaging Analysis of GFP-Tagged Protein Kinase C γ Translocation in Cerebellar Purkinje Cells., Hirai Hirokazu;Fukai Yuuki;Konno Ayumu;Hosoi Nobutake, Feb. 2022, Cerebellum (London, England), 21, 5

  DOI
• D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation., Ueda Erika;Ohta Tomoko;Konno Ayumu;Hirai Hirokazu;Kurauchi Yuki;Katsuki Hiroshi;Seki Takahiro, Apr. 2022, Cells, 11, 7

  DOI
• Plasticity of neural connections underlying oxytocin-mediated parental behaviors of male mice., Inada Kengo;Hagihara Mitsue;Tsujimoto Kazuko;Abe Takaya;Konno Ayumu;Hirai Hirokazu;Kiyonari Hiroshi;Miyamichi Kazunari, Apr. 2022, Neuron, 110, 12

  DOI
• Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation., Tokuyama Takeshi;Uosaki Hideki;Sugiura Ayumu;Nishitai Gen;Takeda Keisuke;Nagashima Shun;Shiiba Isshin;Ito Naoki;Amo Taku;Mohri Satoshi;Nishimura Akiyuki;Nishida Motohiro;Konno Ayumu;Hirai Hirokazu;Ishido Satoshi;Yoshizawa Takahiro;Shindo Takayuki;Takada Shingo;Kinugawa Shintaro;Inatome Ryoko;Yanagi Shigeru, Jun. 2022, iScience, 25, 7

  DOI
• Indirect Negative Effect of Mutant Ataxin-1 on Short- and Long-Term Synaptic Plasticity in Mouse Models of Spinocerebellar Ataxia Type 1., Shuvaev Anton N;Belozor Olga S;Mozhei Oleg I;Shuvaev Andrey N;Fritsler Yana V;Khilazheva Elena D;Mosyagina Angelina I;Hirai Hirokazu;Teschemacher Anja G;Kasparov Sergey, Jul. 2022, Cells, 11, 14

  DOI
• Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation., Wang Xiaowen;Delle Christine;Asiminas Antonis;Akther Sonam;Vittani Marta;Brøgger Peter;Kusk Peter;Vo Camilla Trang;Radovanovic Tessa;Konno Ayumu;Hirai Hirokazu;Fukuda Masahiro;Weikop Pia;Goldman Steven A;Nedergaard Maiken;Hirase Hajime, Sep. 2022, Cell reports methods, 2, 10

  DOI
• Synaptic pruning through glial synapse engulfment upon motor learning., Morizawa Yosuke M;Matsumoto Mami;Nakashima Yuka;Endo Narumi;Aida Tomomi;Ishikane Hiroshi;Beppu Kaoru;Moritoh Satoru;Inada Hitoshi;Osumi Noriko;Shigetomi Eiji;Koizumi Schuichi;Yang Guang;Hirai Hirokazu;Tanaka Kohichi;Tanaka Kenji F;Ohno Nobuhiko;Fukazawa Yugo;Matsui Ko, Nov. 2022, Nature neuroscience, 25, 11

  DOI
• Long-term depression-inductive stimulation causes long-term potentiation in mouse Purkinje cells with a mutant thyroid hormone receptor., Ninomiya Ayane;Amano Izuki;Kokubo Michifumi;Takatsuru Yusuke;Ishii Sumiyasu;Hirai Hirokazu;Hosoi Nobutake;Koibuchi Noriyuki, Nov. 2022, Proceedings of the National Academy of Sciences of the United States of America, 119, 45

  DOI
• Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo., Okada Yukihiro;Hosoi Nobutake;Matsuzaki Yasunori;Fukai Yuuki;Hiraga Akito;Nakai Junichi;Nitta Keisuke;Shinohara Yoichiro;Konno Ayumu;Hirai Hirokazu, Nov. 2022, Communications biology, 5, 1

  DOI
• DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers., Jin Mingyue;Matsumoto Sakiko;Ayaki Takashi;Yamakado Hodaka;Taguchi Tomoyuki;Togawa Natsuko;Konno Ayumu;Hirai Hirokazu;Nakajima Hiroshi;Komai Shoji;Ishida Ryuichi;Chiba Syuhei;Takahashi Ryosuke;Takao Toshifumi;Hirotsune Shinji, Nov. 2022, Nature communications, 13, 1

  DOI
• Development and Optimization of a Multilayer Rat Purkinje Neuron Culture., Uggerud Ida Margrethe;Kråkenes Torbjørn;Hirai Hirokazu;Vedeler Christian Alexander;Schubert Manja, Jan. 2023, Cerebellum (London, England), 23, 1

  DOI
• A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant., Kawabata Hayato;Konno Ayumu;Matsuzaki Yasunori;Hirai Hirokazu, Mar. 2023, Molecular therapy. Methods & clinical development, 29

  DOI
• Dynamic modulation of pulsatile activities of oxytocin neurons in lactating wild-type mice., Yaguchi Kasane;Hagihara Mitsue;Konno Ayumu;Hirai Hirokazu;Yukinaga Hiroko;Miyamichi Kazunari, May 2023, PloS one, 18, 5

  DOI
• Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis., Ichinose Sotaro;Susuki Yoshihiro;Hosoi Nobutake;Kaneko Ryosuke;Ebihara Mizuho;Hirai Hirokazu;Iwasaki Hirohide, Jun. 2023, eLife, 12

  DOI
• Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans., Murase Shuhei;Sakitani Naoyoshi;Maekawa Takahiro;Yoshino Daisuke;Takano Kouji;Konno Ayumu;Hirai Hirokazu;Saito Taku;Tanaka Sakae;Shinohara Keisuke;Kishi Takuya;Yoshikawa Yuki;Sakai Takamasa;Ayaori Makoto;Inanami Hirohiko;Tomiyasu Koji;Takashima Atsushi;Ogata Toru;Tsuchimochi Hirotsugu;Sato Shinya;Saito Shigeyoshi;Yoshino Kohzoh;Matsuura Yuiko;Funamoto Kenichi;Ochi Hiroki;Shinohara Masahiro;Nagao Motoshi;Sawada Yasuhiro, Jul. 2023, Nature biomedical engineering, 7, 11

  DOI
• Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes., Ozawa Katsuya;Nagao Masaki;Konno Ayumu;Iwai Youichi;Vittani Marta;Kusk Peter;Mishima Tsuneko;Hirai Hirokazu;Nedergaard Maiken;Hirase Hajime, Sep. 2023, International journal of molecular sciences, 24, 17

  DOI
• Author Correction: Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans., Murase Shuhei;Sakitani Naoyoshi;Maekawa Takahiro;Yoshino Daisuke;Takano Kouji;Konno Ayumu;Hirai Hirokazu;Saito Taku;Tanaka Sakae;Shinohara Keisuke;Kishi Takuya;Yoshikawa Yuki;Sakai Takamasa;Ayaori Makoto;Inanami Hirohiko;Tomiyasu Koji;Takashima Atsushi;Ogata Toru;Tsuchimochi Hirotsugu;Sato Shinya;Saito Shigeyoshi;Yoshino Kohzoh;Matsuura Yuiko;Funamoto Kenichi;Ochi Hiroki;Shinohara Masahiro;Nagao Motoshi;Sawada Yasuhiro, Nature biomedical engineering, 7, 11

  DOI
• State-dependent modulation of positive and negative affective valences by a parabrachial nucleus-to-ventral tegmental area pathway in mice., Nagashima Takashi;Mikami Kaori;Tohyama Suguru;Konno Ayumu;Hirai Hirokazu;Watabe Ayako M, Nov. 2023, Frontiers in neural circuits, 17

  DOI
• Excitatory subtypes of the lateral amygdala neurons are differentially involved in regulation of synaptic plasticity and excitation/inhibition balance in aversive learning in mice., Morishima Mieko;Matsumura Sohta;Tohyama Suguru;Nagashima Takashi;Konno Ayumu;Hirai Hirokazu;Watabe Ayako M, Dec. 2023, Frontiers in cellular neuroscience, 17

  DOI
• Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization., Kawabata Hayato;Konno Ayumu;Matsuzaki Yasunori;Sato Yumika;Kawachi Mika;Aoki Ryo;Tsutsumi Saki;Togai Shota;Kobayashi Ryosuke;Horii Takuro;Hatada Izuho;Hirai Hirokazu, Jan. 2024, Molecular therapy. Methods & clinical development, 32, 1

  DOI
• Anxiety control by astrocytes in the lateral habenula., Tan Wanqin;Ikoma Yoko;Takahashi Yusuke;Konno Ayumu;Hirai Hirokazu;Hirase Hajime;Matsui Ko, Feb. 2024, Neuroscience research

  DOI
• Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells., Watanave Masashi;Kawachi Mika;Konno Ayumu;Aoki Ryo;Fukai Yuuki;Matsuzaki Yasunori;Kaneko Ryosuke;Hirai Hirokazu, Feb. 2024, Frontiers in cellular neuroscience, 18

  DOI
• Production of the neuron-specific enolase in astrocytes, but not in neurons, under the neuronal inflammation, Hirai Hirokazu, Apr. 2017, 89, 2, 241, 243

  DOI
• 発現増強因子WPREの短鎖化がマウス脳におけるアデノ随伴ウイルスベクターによる遺伝子発現強度に及ぼす影響, ;;;;, Mar. 2022, 142年会, 28PO7
• プルキンエ細胞特異的に発現させた変異甲状腺ホルモン受容体の運動機能調節における作用, ;;;;;, Apr. 2022, 98, 1, 317

MISC

• A Case of Dermatofibrosarcoma Protuberans with Bronchial Submucosal Metastasis, Hirokazu Hirai; Shuji Adachi; Eiro Sakai; Masahiko Kusumoto; Eiichiro Itouji; Michio Kono, 1992, Haigan, 32, 1, 89, 94

  DOI
• 5. 特異な内視鏡所見を示した Dermatofibrosarcoma protuberance の肺転移の 1 例(第 40 回近畿気管支鏡懇話会), 平井 宏和; 楠本 昌彦; 酒井 英郎; 田中 浩司; 足立 秀治; 河野 通雄, 25 Jan. 1991, 13, 1
• 32 肺癌に於けるFilm Digitizer とCompuetd Radiography によるDigital Image の有用性について, 山崎 克人; 平井 宏和; 楠本 昌彦; 酒井 英郎; 田中 浩司; 足立 秀治; 河野 通雄, 01 Oct. 1990, 30, 5
• 慢性トルエン中毒のMRI, 平井宏和; 池内裕司, May 1993, 33, 5, 552, 555
• Quantitative analysis of sodium fast and slow component in in vivo human brain tissue using MR Na image, H. Hirai; K. Yamasaki; H. Kidena; M. Kono, 1992, Kakuigaku, 29, 12, 1447, 1454
• 記憶の分子機構はどこまでわかったか?グルタミン酸受容体のリン酸化と運動学習, 平井 宏和, 25 Dec. 2000, 38, 12, 772, 774
• 免疫系で有名なCD38が「子育て」「他者の認識・記憶」に必要, 平井 宏和, 01 May 2007, 69, 5
• 神経伝達物質受容体のクラスタリング, 平井 宏和, Feb. 1999, 50, 1, 72, 74

  DOI
• CRAGを用いたポリグルタミン病の遺伝子治療, 柳茂; 寅嶋崇; 平井宏和, 2008, 3S25-7
• CRAGによるポリグルタミン病原因タンパクの分解機構, 長島駿; 窪田有花; 寅嶋崇; 平井宏和; 稲留涼子; 福田敏史; 柳茂, 2008, 3T22-3
• 急性脳炎のグルタミン酸受容体自己免疫病態の解明から新たな治療法確立に向けた研究 急性辺縁系脳炎・脳症が疑われた剖検例の海馬の免疫組織学的検討と,患者髄液中での抗GluRδ2抗体の検討, 岡本幸市; 坂野晴彦; 吉田眞理; 高玉真光; 鈴木豊; 高山清彦; 平井宏和, 2008, 70, 72
• 「子育て」「他者の認識と記憶」に必要な膜タンパク質CD38, 平井宏和, 01 Aug. 2007, 57, 3, 288
• 足場タンパク質JSAP1はマウス顆粒前駆細胞の増殖を負に制御する, 佐藤時春; 寅嶋崇; 寅嶋崇; 杉原一司; 平井宏和; 浅野雅秀; 善岡克次, 2007, 4P-0769
• グルタミン酸受容体リン酸化と運動学習制御, 平井宏和, 20 Dec. 2006, 2007, 123-140,4-5
• クローズアップ実験法 Series161 神経細胞選択的なHIV由来レンチウイルスベクターの作製法, 平井宏和; 平井宏和, 01 Dec. 2006, 24, 19, 2997, 3001
• 運動・行動 3.小脳のシナプス形成とシナプス可塑性を制御する分子・細胞メカニズム, 平井宏和, 20 Sep. 2006, 24, 15, 2402-2409,2226(4)
• 小脳初代培養系を用いた足場タンパク質JSAP1の解析, 佐藤時春; 岩永飛鳥; 寅嶋崇; 杉原一司; 平井宏和; 浅野雅秀; 善岡克次, 25 Nov. 2005, 28th, 298
• ポストゲノム時代のブラックボックス 行動を司る脳機能の分子メカニズム 遺伝子レスキューマウス作出による小脳の運動学習機構の解明, 平井宏和, 01 May 2005, 23, 8, 1170, 1175
• 大人の小脳におけるδ2グルタミン酸受容体シグナルの役割 協調運動,運動学習への関与について, 平井宏和; ローニー トーマス; 三河須美子; 柳原大; 笠浦毅; 宮本章弘; 柚崎通介, 26 Sep. 2001, 24th, 242
• 大人の小脳におけるδ2グルタミン酸受容体シグナルの役割 協調運動,運動学習への関与について, 平井宏和; ローニー トーマス; 三河須美子; 柳原大; 笠浦毅; 宮本章弘; 柚崎通介, 01 Sep. 2001, 40, 2/3, 298
• 記憶の分子機構はどこまでわかったか? グルタミン酸受容体のリン酸化と運動学習, 平井宏和, 25 Dec. 2000, 38, 12, 772, 774
• 小脳プルキンエ細胞樹状突起の発育制御メカニズム か粒細胞のNMDA受容体活性化がカギを握る, 寅嶋崇; LAUNEY T; 平井宏和, 04 Sep. 2000, 23rd, 237
• 小脳LTDの分子機構 GluR2のリン酸化を介したプルキンエ細胞シナプス後膜上のAMPA型受容体密度の調節, 平井宏和; 松田信爾; 三河須美子, 04 Sep. 2000, 23rd, 88
• PKCによるGluR2 Ser 880のリン酸化が小脳LTDを誘導する, 松田信爾; LAUNEY T; 寅島崇; 三河須美子; 平井宏和, 04 Sep. 2000, 23rd, 131
• プルキンエ細胞きょく突起内のδ型グルタミン酸受容体クラスターはアクチン細胞骨格により固定される, 平井宏和; 松田信爾, 06 Jul. 1999, 22nd, 356
• 「子育て」「他者の認識と記憶」に必要な膜タンパク質CD38(特別講演,第54回北関東医学会総会抄録), 平井宏和, 01 Aug. 2007, 57, 3
• 改訂 脊髄小脳変性症のすべて SCDマウスの運動障害を遺伝子治療で大幅に改善, 平井 宏和, May 2008, 14, 2, 43, 46
• レンチウイルスベクターを用いた脊髄小脳変性症の遺伝子治療, 平井宏和, 01 Aug. 2008, 58, 3, 325, 326

  DOI
• ウイルスの組織細胞化学への応用 レンチウイルスベクターの作製方法とその応用, 平井宏和, 10 Jul. 2008, 2008, 93, 99
• 改訂 脊髄小脳変性症のすべて SCDマウスの運動障害を遺伝子治療で大幅に改善, 平井宏和, 01 May 2008, 14, 2, 43, 46
• 群馬大学医学部と生体調節研究所 (大学紹介), 平井宏和; 北村忠弘, Aug. 2008, 24, 118, 119
• レンチウイルスベクターの作製方法とその応用(D.ウイルスの組織細胞化学への応用), 平井宏和, 10 Jul. 2008, 2008, 93, 99
• Potential and perspective of gene therapy against neuronal disorders, 平井 宏和, Jan. 2009, 60, 1, 23, 30

  DOI
• 最近の知見からみるオキシトシンと母性の新しい概念 (生殖医学) -- (基礎分野での進歩), 平井 宏和, 2009, 2009, 196, 201
• クローズアップ実験法 Series195 ウイルスベクターを用いた成熟マウス小脳皮質への遺伝子導入法, 平井宏和, 01 Oct. 2009, 27, 16, 2633, 2637
• レンチウイルスベクターを用いた運動失調マウスの機能回復, 平井宏和, 31 Aug. 2009, 25, 75, 77
• 遺伝子‐脳回路‐行動 脳の遺伝子治療の可能性と展望, 平井宏和, 15 Feb. 2009, 60, 1, 23, 30

  DOI
• 生殖医学 A.基礎分野での進歩 2.最近の知見からみるオキシトシンと母性の新しい概念, 平井宏和, 25 Jan. 2009, 2009, 196, 201
• レンチウイルスベクターを用いた運動失調マウスの機能回復, 飯塚朗; 寅嶋崇; 三ツ村一浩; 小山知穂; 平井宏和, 2009, 24th, 84
• 運動失調症の病態解明と治療法開発に関する研究 運動失調症に関する調査研究 脊髄小脳変性症遺伝子治療用ウイルスベクターの開発, 平井宏和; 寅嶋崇; 大上美穂; 飯塚朗; 山口晴保, 2009, 53, 55
• 小脳変性疾患の遺伝子治療―ウイルスベクターの可能性と今後の展望―, 平井宏和, 2009, 24th, 20, 21
• レンチウイルスベクターを用いた運動失調マウスの遺伝子治療の試み~デルタ2グルタミン酸受容体の長期発現による機能回復~, 飯塚朗; 寅嶋崇; 三ツ村一浩; 小山知穂; 平井宏和, 2009, 56th, 14
• レンチウイルスベクターを用いた運動失調マウスの機能回復 (助成研究報告), 平井宏和, Aug. 2009, 25, 75, 77
• 運動失調症の病態解明と治療法開発に関する研究 脊髄小脳変性症14型変異PKCによる小脳シナプス機能変化に関する研究, 中村和裕; 平井宏和, 2012, 85, 87
• 運動失調症の病態解明と治療法開発に関する調査研究 ポリグルタミン病モデルマウスに対する凝集阻害分子の遺伝子治療による治療効果, 永井義隆; POPIEL H A; 平井宏和; 村松慎一; 戸田達史; 和田圭司, 2011, 17, 19
• 運動失調症の病態解明と治療法開発に関する研究 遺伝性脊髄小脳変性症の病態解明と遺伝子治療に関する研究, 平井宏和; 飯塚朗; 高山清彦; SHUVAEV Anton N, 2011, 20, 22
• 運動失調症の病態解明と治療法開発に関する研究 脊髄小脳変性症の病態解明と治療法開発に関する研究, 平井宏和; 飯塚朗; 高山清彦; SHUVAEV Anton N, 2011, 91, 93
• 脊髄小脳変性症の遺伝子治療法開発, 平井宏和, 2010, 24, ROMBUNNO.49
• デルタ2グルタミン酸受容体のNTDを介する新しい活性化様式の解明, 平井宏和, 2010, 176, 177
• 運動失調症の病態解明と治療法開発に関する研究 運動失調症に関する調査研究 遺伝性脊髄小脳変性症の遺伝子治療法開発, 平井宏和; 飯塚朗; 高山清彦, 2010, 34, 36
• Lentiviral-Vector-Mediated Genetherapy for the Spinocerebellar Ataxia(STREAM), Hirai H, 01 Aug. 2008, The KITAKANTO medical journal, 58, 3, 325, 326

  DOI
• PROFILE, 平井宏和, 01 Feb. 2007, 69, 2, 71, 72
• 小脳機能維持における甲状腺ホルモンの新たな役割の解明 プルキンエ細胞小胞体からのカルシウム放出調節における重要性, 二ノ宮 彩音; 細井 延武; 天野 出月; 小久保 倫文; 高鶴 裕介; 平井 宏和; 鯉淵 典之, Apr. 2021, 97, 1, 265, 265
• 【小脳研究の未来】病態 遺伝子改変疾患マウスと小脳異常, 細井 延武; 平井 宏和, Feb. 2021, 72, 1, 69, 73
• 初代培養小脳Purkinje細胞の樹状突起発達に対するD-cysteineの効果, 関 貴弘; 佐藤 正寛; 今野 歩; 平井 宏和; 倉内 祐樹; 香月 博志, Sep. 2019, 60回, 69, 69
• 脊髄小脳変性症14型モデルマウスを用いた薬物治療法の探索, 小金丸 泉; 足立 直子; 今野 歩; 中園 葵; 関 貴弘; 上山 健彦; 酒井 規雄; 平井 宏和; 齋藤 尚亮, Sep. 2019, 60回, 70, 70
• 脊髄小脳失調症21型モデルマウスにおける運動障害とグリア細胞活性化, 太田 智子; 関 貴弘; 木部 友貴; 今野 歩; 平井 宏和; 倉内 祐樹; 香月 博志, Sep. 2019, 60回, 81, 81
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, 定方 哲史; 細井 延武; 柴崎 貢志; 今野 歩; 平井 宏和; 石崎 泰樹; 古市 貞一, Sep. 2019, 日本生化学会大会プログラム・講演要旨集, 92回, [1T14a, 01]
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, 定方 哲史; 細井 延武; 柴崎 貢志; 今野 歩; 平井 宏和; 石崎 泰樹; 古市 貞一, Sep. 2019, 日本生化学会大会プログラム・講演要旨集, 92回, [1T14a, 01]
• 【小脳学習説Marr-Albus-Ito理論の50年】機能障害と治療 ウイルスベクター経静脈投与による脊髄小脳変性症動物モデルの作出, 平井 宏和, Aug. 2019, 37, 8, 998, 1002
• クローズアップ実験法(series 308) ウイルスベクターの静脈投与によるマウス脳全域への遺伝子導入, 今野 歩; 平井 宏和, Mar. 2019, 37, 4, 581, 587
• モデルマウスを用いた本態性振戦発症機序の解明, 細井 延武; 柴崎 貢志; 今野 歩; 村松 慎一; 石崎 泰樹; 平井 宏和; 古市 貞一; 定方 哲史, Aug. 2018, 68, 3, 211, 211
• モデルマウスを用いた本態性振戦発症機序の解明, 細井延武; 柴崎貢志; 今野歩; 村松慎一; 石崎泰樹; 平井宏和; 古市貞一; 定方哲史, Aug. 2018, 北関東医学会総会プログラム・抄録, 65th, 3, 31, 211
• 脊髄小脳失調症の原因となる変異transmembrane protein 240の小脳神経細胞への発現は神経細胞死を起こさずにグリオーシス及び運動機能障害を引き起こす, 関 貴弘; 木部 友貴; 太田 智子; 倉内 祐樹; 今野 歩; 平井 宏和; 久恒 昭哲; 香月 博志, Mar. 2018, 138年会, 3, 95, 95
• リピート病における神経変性の分子機構解明を目指して アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, 今野 歩; 渡邊 将; 星野 千秋; 篠原 洋一郎; 松崎 泰教; 平井 宏和, Dec. 2017, 2017年度, [3PW23, 3]
• 小脳プルキンエ細胞における古典的Cキナーゼαとγの発現量と生理機能(Expression levels and physiological significance of protein kinase C α and γ in cerebellar Purkinje cells), 平井 宏和, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 159, 159
• アデノ随伴ウイルスベクターを用いた神経細胞特異的NSEプロモーターの解析, 篠原 洋一郎; 今野 歩; 大谷 理了; 平井 宏和, Aug. 2017, 67, 3, 273, 273
• "ニューロン特異的エノラーゼ(NSE)"は炎症があるとニューロンではなくグリア細胞で産生される, 平井 宏和, Apr. 2017, 89, 2, 241, 243
• 【基底核と小脳-その相違と連関】生理機能 小脳の機能, 平井 宏和, Jan. 2017, 35, 1, 28, 32
• 神経変性疾患の最前線2016 運動の記憶を形成する細胞内シグナル 脊髄小脳変性症マウスを用いた解析と治療の可能性(Signaling pathway required for motor memory formation: Studies using spinocerebellar ataxia model mice and the therapeutic perspective), 平井 宏和; シュワエフ・アントン; 細井 延武, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集, 46回, 84, 84
• 私はなぜ研究医を目指したか 文部科学省GPプログラムや他の取組みの検証 群馬大学「卒前・卒後一貫MD-PhDコース」を経験して, 澤田 悠輔; 平井 宏和; 鯉淵 典之; 石崎 泰樹; 和泉 孝志; 峯岸 敬, Jul. 2016, 医学教育, 47, Suppl., 23, 23
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry Chan; Hirokazu Hirai, May 2015, MOLECULAR THERAPY, 23, S237, S237, Summary international conference
• 脊髄小脳変性症 ミクログリア動態に対する運動効果の検討, 須藤 奈々; 中村 和裕; 平井 宏和, Feb. 2015, 65, 1, 123, 124
• 【よくわかる遺伝子】単一遺伝子異常と疾患 脊髄小脳変性症と平衡障害, 平井 宏和, Jun. 2014, 30, 6, 759, 762
• Npas4 regulates the expression of Mdm2 that ubiquitinates Dcx to remodel dendritic spines in olfactory bulb interneurons after sensory experience., Yoshihara S; Takahashi H; Nishimura N; Kinoshita M; Asahina R; Kitsuki M; Tatsumi K; Hibi Y; Hirai H; Nagai T; Yamada K; Tsuboi A, 2014, Cell Rep, 8, 1-15, Report scientific journal
• 成熟細胞の寿命制御機構とその破綻による病態 Retinoid-related orphan receptorα(RORα)が制御する小脳プルキンエ細胞の発達と寿命, 平井 宏和, Sep. 2013, 86回, 3S17p, 4
• 脊髄小脳変性症 ミクログリア動態に対する運動効果の検討, 須藤 奈々; 中村 和裕; 平井 宏和, Aug. 2013, 63, 3, 209, 215
• 小脳失調症の原因である変異型Kv3.3は培養小脳プルキンエ細胞の樹状突起発達不全と細胞死を引き起こす, 入江 智彦; 松崎 泰教; 関野 祐子; 平井 宏和, Jul. 2013, 75, 4, 187, 187
• 嗅球介在ニューロンによる感覚入力依存的な神経回路再編の分子機構, 吉原 誠一; 高橋 弘雄; 平井 宏和; 吉原 良浩; 森 憲作; Stern Peter L.; 坪井 昭夫, Jun. 2013, 64, 1・2・3, 46, 47
• Kv3.3 channels harboring a missense mutation of spinocerebellar ataxia type 13 alter neuronal excitability and induce apoptotic cell death in cultured cerebellar Purkinje cells of mice, Tomohiko Irie; Yasunori Matsuzaki; Yuko Sekino; Hirokazu Hirai, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S244, S244, Summary international conference
• Mutant gamma PKC found in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo, Anton Nikolaevich Shuvaev; Hajime Horiuchi; Takahiro Seki; Gennawan Hanna; Tomohiko Irie; Akira Iizuka; Norio Sakai; Hirokazu Hirai, 2011, NEUROSCIENCE RESEARCH, 71, E291, E292, Summary international conference

  DOI
• Disruption of climbing fiber synapse elimination and LTD expression in cerebellar Purkinje cells by mutant gamma PKC found in spinocerebellar ataxia type 14, Hirokazu Hirai; Shuvaev Anton; Takahiro Seki; Norio Sakai, 2011, NEUROSCIENCE RESEARCH, 71, E57, E57, Summary international conference

  DOI
• Impairment of mGluR signaling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice, Nobutake Hosoi; Kazuhiro Mitsumura; Hirokazu Hirai, 2011, NEUROSCIENCE RESEARCH, 71, E246, E246, Summary international conference

  DOI
• レンチウイルスベクターを用いた小脳の発達・再生研究(Study of cerebellar development and regeneration, using the lentiviral vector), 平井 宏和; 澤田 悠輔; 梶原 剛, Aug. 2010, 神経化学, 49, 2-3, 543, 543
• Study of cerebellar development and regeneration, using the lentiviral vector, Hirokazu Hirai; Yusuke Sawada; Go Kajiwara, 2010, NEUROSCIENCE RESEARCH, 68, E140, E140, Summary international conference

  DOI
• A PKC gamma mutation in spinocerebellar ataxia type 14 impairs PKC functions in a dominant-negative manner in cerebellar Purkinje cells in vivo, Anton Shuvaev; Tomohiko Irie; Hajime Horiuchi; Akira Iiduka; Masae Iino; Takahiro Seki; Norio Sakai; Hirokazu Hirai, 2010, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S110, S110, Summary international conference
• A PKC gamma MUTATIONS IN SPINOCEREBELLAR TAXIA TYPE 14 IMPAIRS PKC FUNCTIONS IN CEREBELLAR PURKINJE CELLS IN VIVO, Anton Nikolaevich Shuvaev; Hirokazu Hirai; Norio Sakai; Takahiro Seki; Masae Iino; Hajime Horiuchi, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 138, 138, Summary international conference
• Lentiviral vector-mediated rescue of motor behavior in hereditary ataxic mice, Akira Iizuka; Takashi Torashima; Kazuhiro Mitsumura; Chiho Koyama; Masae Iino; Hirokazu Hirai, 2009, NEUROSCIENCE RESEARCH, 65, S96, S96, Summary international conference

  DOI
• A PKC gamma mutation in spinocerebellar ataxia type 14 impairs PKC functions in a dominant-negative manner in cerebellar Purkinje cells in vivo, Anton Shuvaev; Hajime Horiuchi; Akira Iizuka; Tomohiko Irie; Masae Iino; Takahiro Seki; Norio Sakai; Hirokazu Hirai, 2009, NEUROSCIENCE RESEARCH, 65, S247, S247, Summary international conference

  DOI
• Influence of lentiviral vector infection on the development of cerebellar Purkinje cells in vivo, Yusuke Sawada; Go Kajiwara; Takashi Torashima; Kiyohiko Takayama; Hajime Horiuchi; Akira Iizuka; Kazuhiro Mitsumura; Hirokazu Hirai, 2009, NEUROSCIENCE RESEARCH, 65, S89, S90, Summary international conference

  DOI
• RESCUE OF ABNORMAL PHENOTYPES IN delta 2 GLUTAMATE-RECEPTOR-NULL MICE BY THE EXTRACELLULAR N-TERMINAL DOMAIN, Takashi Torashima; Akira Iizuka; Hajime Horiuchi; Kazuhiro Mitsumura; Miwako Yamazaki; Chiho Koyama; Kiyohiko Takayama; Masae Iino; Masahiko Watanabe; Hirokazu Hirai, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 134, 134, Summary international conference
• Progress of the delta 2 glutamate receptor research from the viewpoint of functional domains, Hirokazu Hirai; Takashi Torashima; Akira Iizuka, 2009, NEUROSCIENCE RESEARCH, 65, S9, S9, Summary international conference

  DOI
• Gene therapy enhancing the ubiquitin-proteasome pathway in a mouse model of polyglutamine disease, Hirokazu Hirai; Takashi Torashima; Chiho Koyama; Shigeru Yanagi; Miho Ooue; Haruyasu Yamaguchi, Apr. 2008, JOURNAL OF GENE MEDICINE, 10, 4, 464, 464, Summary international conference
• Purkinje-cell-selective expression of GFP by lentivectors with the MSCV promoter, Kiyohiko Takayama; Takashi Torashima; Hajime Horiuchi; Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S278, S278, Summary international conference
• Recent advances in lentiviral vectors-The application to exploring pathophysiology in the CNS and gene therapy against brain disorders, Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S9, S9, Summary international conference
• Lentivector-mediated expression of mutant ataxin-3 in mouse cerebellar nucleie, Hajime Horiuchi; Takashi Torashima; Kiyohiko Takayama; Akira Iizuka; Kazuhiro Mitsumura; Masae Iino; Chiho Koyama; Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S125, S125, Summary international conference
• Immunoelectronmicroscopic analysis of the inclusions in Purkinje cells of a mouse model of spinocerebellar ataxia, Mine Oue; Takashi Torashima; Haruyasu Yamaguchi; Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S205, S205, Summary international conference
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of polyglutannine disease by enhancing the ubiquitin-proteasome pathway, Takashi Torashima; Haruyasu Yamaguchi; Shigeru Yanagi; Chiho Koyama; Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S125, S125, Summary international conference
• Lentivector-mediated rescue of abnormal phenotype in mice lacking delta 2 glutamate receptors upon expression of the N-terminal domain, Akira Iizuka; Kazuhiro Mistumura; Masae Iino; Tkashi Torashima; Chiho Koyama; Hirokazu Hirai, 2008, NEUROSCIENCE RESEARCH, 61, S148, S148, Summary international conference
• 125I-IBFを用いた脊髄小脳変性症の遺伝子治療用発現イメージング法の開発, 柴 和弘; 小川 数馬; 寅嶋 崇; 平井 宏和; 森 厚文, Mar. 2007, 127年会, 3, 47, 47
• Lentiviral-vector-mediated gene rescue - Functional recovery by region-specific expression of CD38 gene, Hirokazu Hirai; Takashi Torashima; Duo Jin; Hong-Xiang Liu; Olga Lopatina; Mami Noda; Haruhiro Hirashidaa, 2007, NEUROSCIENCE RESEARCH, 58, S68, S68, Summary international conference
• Gene transfer into in vivo cerebellar Purkinje cells by HIV-derived lentiviral vectors, Hirokazu Hirai, 2006, NEUROSCIENCE RESEARCH, 55, S45, S45, Summary international conference
• Ca2+ influx through delta 2 glutamate receptors is not required for cerebellar functions, Wataru Kakegawa; Taisuke Miyazaki; Hirokazu Hirai; Masayoshi Mishina; Masahiko Watanabe; Michisuke Yuzaki, 2006, NEUROSCIENCE RESEARCH, 55, S172, S172, Summary international conference
• レンチウイルスベクターを用いた小脳プルキンエ細胞への遺伝子導入, 平井 宏和, Sep. 2005, 114, 2〜3, 47, 47
• 遺伝子操作動物解析法の新しい展開 遺伝子変異マウスとウイルスベクターを組み合わせた脳機能解析(New analytical techniques for transgenic/knockout mice: Analysis of neural function by virus-mediated gene transfer into mutant mice brain), 平井 宏和, Aug. 2004, 神経化学, 43, 2-3, 340, 340
• Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons (vol 19, pg 2765, 2000), S Matsuda; T Launey; S Mikawa; H Hirai, Jan. 2003, EMBO JOURNAL, 22, 1, 174, 174, Others
• Phosphorylation of serine 880 in GluR2 by protein kinase C prevents its C-terminus binding with the glutamate receptor interacting protein, GR, S Matsuda; S Mikawa; H Hirai, 2000, EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 465, 465, Summary international conference
• グルタミン酸受容体を介したHEK細胞のリン脂質代謝の活性化-NMRによる分析-, 平井 宏和; 寅島 崇; 伊藤 真博; 吉岡 敬太郎; 山田 和廣, Sep. 1998, 37, 3, 398, 398
• in vivoラットの上丘神経伝達におけるアデノシンの興奮作用, 平井 宏和, Dec. 1994, 56, 12, 427, 427
• 内視鏡にて摘出した歯ブラシ誤嚥の1例, 平井 宏和; 池内 裕司; 松岡 俊行, May 1993, 5, 5, 705, 708
• EXCITATORY ACTION OF ADENOSINE ON NEUROTRANSMISSION IN THE SUPERIOR COLLICULUS IS DUE TO INCREASE OF GLUTAMATE RELEASE WHICH INVOLVES PROTEIN-KINASE SYSTEM, Y OKADA; H HIRAI, 1993, JOURNAL OF NEUROCHEMISTRY, 61, S82, S82, Summary international conference
• 123I-IMPによる局所脳血流量の定量的評価, 平井 宏和; 山崎 克人; 山路 滋; 野村 曜子; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄, Aug. 1991, 28, 8, 889, 889
• 肺癌のGa-67SPECTの集積度の半定量化に関する検討, 野村 曜子; 山崎 克人; 山路 滋; 平井 宏和; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄, Aug. 1991, 28, 8, 906, 906
• 肺癌におけるTl-201を用いたSPECTによる集積度の半定量化への試み, 山路 滋; 山崎 克人; 野村 曜子; 平井 宏和; 石井 一成; 北垣 一; 田中 豊; 白坂 今日子; 井上 善夫; 河野 通雄, Aug. 1991, 28, 8, 908, 908
• 脳梗塞におけるMRI Na-imagingによる評価, 平井 宏和, Feb. 1991, 51, 臨増, S320, S320
• 脳梗塞におけるMRI Na-Imagingによる評価, 平井 宏和, Sep. 1990, 27, 9, 1039, 1039

Books etc

• ウイルスベクター経静脈投与による脊髄小脳変性症動物モデルの作出, Aug. 2019
• 脳・神経科学 集中マスター, May 2005, ISBN: 4-89706-938-6
• ブレインサイエンス・レビュー2007, Dec. 2007
• Annual Review　糖尿病・代謝・内分泌2009, Jan. 2009, ISBN: 978-4-498-12330-4
• Gene Therapy Applications, Hirai H, Iizuka A., InTech, Aug. 2011, ISBN: 978-953-307-541-9
• 決定版ウイルスベクターによる遺伝子導入実験ガイド : 培養細胞から個体まで、研究を飛躍させる実践テクニックのすべて, Nov. 2020, 281, 11p, ISBN: 9784758122474

Presentations

• Establishment of a mouse model of spinocerebellar ataxia type 34 via the gene transfer using adeno-associated viral vectors, Yuri Morikawa, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, 第44回日本神経科学大会, 31 Jul. 2021, 28 Jul. 2021, 31 Jul. 2021
• Rearrangement of neural circuits of oxytocin neurons regulates parental behavior in male mice, Kengo Inada, Mitsue Hagihara, Kazuko Tsujimoto, Takaya Abe, Ayumu Konno, Hirokazu Hirai, Hiroshi Kiyonari, Kazunari Miyamichi, 第44回日本神経科学大会, 29 Jul. 2021, 28 Jul. 2021, 31 Jul. 2021
• Long-term treatment of D-cysteine prevents the disease progression in model mice of spinocerebellar ataxia type 1, Takahiro Seki, Tomoko Ohta, Yuri Morikawa, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, 第44回日本神経科学大会, 31 Jul. 2021, 28 Jul. 2021, 31 Jul. 2021
• Protein Kinase Cγ in adult cerebellar Purkinje cells regulates motor coordination and complex spikes through modulation of large conductance potassium channels., Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hirai Hirokazu, 第44回日本神経科学大会, 31 Jul. 2021, 28 Jul. 2021, 31 Jul. 2021
• GABAergic neuron-specific transduction throughout the brain by AAV-PHP.B with a novel GAD65 promoter., Ayumu Konno, Chiaki Hoshino, Nobutake Hosoi, Ryosuke Kaneko, Hirokazu Hirai, 第44回日本神経科学大会, 28 Jul. 2021, 31 Jul. 2021
• Suitable combination of AAV capsid and cell type-specific promoter for effective gene therapy, Hirokazu Hirai, NEURO2022, 03 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022
• A novel method for astrocyte-targeted knockout of a gene in flox mice by intravenous infusion of AAV vectors, Hayato Kawabata, Ayumu Konno, Yumika Sato, Mika Kawachi, Hirokazu Hirai, NEURO2022, 30 Jun. 2022, 30 Jun. 2022, 03 Jul. 2022
• Development of adeno-associated viral vector-optimized inhibitory neuron-specific promoters, Yuuki Fukai, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai, NEURO2022, 01 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022
• Recording of pulsatile activities of Oxytocin neurons in lactating wild-type mice via a minipromoter driven AAV vector, Kasane Yaguchi, Hiroko Yukinaga, Ayumu Konno, Hirokazu Hirai, Kazunari Miyamichi, NEURO2022, 01 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022
• Unraveling physiological roles of protein kinase Cy in mature mouse cerebellum - Regulation of motor coordination through modulation of large conductance potassium channels, Hirokazu Hirai, The 11th SRCA International Symposium, 18 Jun. 2021, 18 Jun. 2021, 19 Jun. 2021
• Deletion of class Ⅱ ARFs causes tremor by disruption of Nav1.6 localization to the axon initial segment of cerebellar Purkinje cells in mice., Nobutake Hosoi, Koji Shibasaki, Teiichi Furuichi, Hirokazu Hirai, Tetsushi Sadakata, FENS2020 Virtual Forum, 11 Jul. 2020, 15 Jul. 2020
• Battle of recombinases and novel genetically engineered strategies for split-tunable expression of multiple transgenes in the nervous system., Keigo Kohara, Akitoshi Inoue, Yousuke Nakano, Hirokazu Hirai, Takuya Kobayashi, Masato Maruyama, Tomo Unzai, Ryosuke Baba, Chiho Kawashima, 第43回日本神経科学大会, 29 Jul. 2020, 01 Aug. 2020
• Protein kinase Cγmodulation of large conductance calcium-activated potassium channel properties in mature Purkinje cells contributes to the wave form of complex spike., Masashi Watanave, Nobutaka Takahashi, Ayumu Konno, Hirokazu Hirai, 第43回日本神経科学大会, 29 Jul. 2020, 01 Aug. 2020
• Oxytocin neurons facilitate parental behavior in males., Kengo Inada, Mitsue Hagihara, Kazuko Tsujimoto, Ayumu Konno, Hirokazu Hirai, Kazunari Miyamichi, 第43回日本神経科学大会, 29 Jul. 2020, 01 Aug. 2020
• Motor dysfunction and neurodegeneration are triggered by miRNA-madiated knockdown of LAMP2A in cerebellar neurons., Takahiro Seki, Masahiro Sato, Tomoko Ohta, Yuri Morikawa, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, 第43回日本神経科学大会, 29 Jul. 2020, 01 Aug. 2020
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of polyglutamine disease by enhancing the ubiquitin-proteasome pathway , T. TORASHIMA, H. YAMAGUCHI, S. YANAGI, M. OUE, C. KOYAMA, K. TAKAYAMA, H. HORIUCHI, A. IIZUKA, H. HIRAI, Neuroscience Society, 04 Nov. 2007, San Diego
• 「子育て」｢他者の認識と記憶」に必要な膜タンパク質CD３８, 平井宏和, 第54回北関東医学会総会, 28 Sep. 2007
• Gene therapy enhancing the ubiquitin-proteasome pathway in a mouse model of polyglutamine disease, 平井宏和、寅嶋崇、小山知穂、柳茂、大上美穂、山口晴保, 第１３回日本遺伝子治療学会, 30 Jun. 2007
• レンチウイルスベクターを用いた遺伝子レスキュー　－ CD38 遺伝子の脳部位特異的発現による機能回復－, 平井宏和、寅嶋崇、Duo Jin、Hong-Xiang Liu、Olga Lopatina、野田百美、東田陽博, 第30回日本神経科学大会, 11 Sep. 2007
• CD38は細胞内のカルシウム濃度の調整つを通じてオキシトシンの放出に影響する, 金鐸、劉鴻翔、橋井美奈子、平井宏和、東田陽博, Neuro2007（第30回日本神経科学大会）, 11 Sep. 2007
• レンチウイルスベクターを用いたδ2グルタミン酸受容体欠損マウスのレスキュー―アミノ酸リガンド結合部位及びチャネルポアが欠損しても機能は障害されない―, 飯塚朗、三ツ村一浩、小山知穂、寅嶋崇、飯野昌枝、平井宏和, 第85回日本生理学会大会, 26 Mar. 2008
• Rescue of cerebellar ataxia in polyglutamine-disease-model mice by enhancing the ubiquitin-proteasome pathway, Hirokazu Hirai, 03 Oct. 2007, Krasnoyarsk/Russia
• Oxytocinの行動規範に関わる分子, 平井宏和, 日本神経内分泌学会, 05 Aug. 2007
• レンチウイルスベクターを用いたCRAG発現による脊髄小脳変性症モデルマウスのシナプス伝達及び可塑性の回復, 三ツ村一浩、飯野昌枝、飯塚朗、寅嶋崇、小山知穂、高山清彦、堀内始、平井宏和, 第85回日本生理学会大会, 26 Mar. 2008
• Rescue of abnormal phenotypes in σ2 glutamate-receptor-null mice by the extracellular N-terminal domain, Takashi Torashima，Akira Iizuka，Hajime Horiuchi，Kazuhiro Mitsumura，Miwako Yamazaki，Chiho Koyama，Kiyohiko Takayama，Masae Iino，Masahiko Watanabe，Hirokazu Hirai, IUPS2009, 28 Jul. 2009, Kyoto
• A PKCγ mutations in spinocerebellar taxia type 14 impairs PKC functions in cerebellar purkinje cells IN VIVO, Anton Nikolaevich Shuvaev，Hirokazu Hirai，Norio Sakai，Takahiro Seki，Masae Iino，Hajime Horiuchi, IUPS2009, 28 Jul. 2009, Kyoto
• 機能ドメインを土台としたδ2グルタミン酸受容体研究の進展, 平井 宏和，寅嶋 崇，飯塚 朗, 第32回日本神経科学大会, 16 Sep. 2009
• 脊髄小脳変性症14型を引き起こすPKCγ変異によるプルキンエ細胞の機能障害機構の解明, Anton Shuvaev，堀内 始，飯塚 朗，入江 智彦，飯野 昌枝，関 貴弘，酒井 規雄，平井 宏和, 第32回日本神経科学大会, 16 Sep. 2009
• レンチウイルスベクターを用いた遺伝性運動失調マウスの機能回復, 飯塚 朗，寅嶋 崇，三ツ村 一浩，小山 知穂，飯野 昌枝，平井 宏和, 第32回日本神経科学大会, 16 Sep. 2009
• 高力価レンチウイルスベクターの感染が小脳プルキンエ細胞の発達におよぼす影響の検討, 澤田 悠輔，梶原 剛，寅嶋 崇，高山 清彦，堀内 始，飯塚 朗，三ツ村 一浩，平井 宏和, 第32回日本神経科学大会, 16 Sep. 2009
• レンチウイルスベクターを用いたプルキンエ細胞選択的なGFP発現, 高山 清彦、寅嶋 崇、堀内 始、平井 宏和, 第31回日本神経科学大会, 11 Jul. 2008
• モデルマウスを用いた脊髄小脳変性症の病態解明と遺伝子治療法の開発, 平井 宏和, 第9回バイオサイエンスシンポジウム, 14 Mar. 2008
• Purkinje-cell-selective transduction by the MSCV promoter incorporated in lentiviral vectors, KIYOHIKO TAKAYAMA，TAKASHI TORASHIMA，HAJIME HORIUCHI，HIROKAZU HIRAI, Neurosience2008), 19 Nov. 2008, Washington DC
• レンチウイルスベクターを用いたRORα欠損Staggererマウスの機能回復, 平井 宏和, 第39回病態代謝研究会研究報告会, 18 Oct. 2008
• レンチウイルスベクターを用いた小脳の発達・再生研究, 平井 宏和，澤田 悠輔，梶原 剛, Neuro2010, 02 Sep. 2010
• デルタ2グルタミン酸受容体のNTDを介する新しい活性化様式の解明, 平井 宏和, 文部科学省特定領域研究「統合脳」夏のワークショップ, 07 Aug. 2008
• デルタ2グルタミン酸受容体のNTDを介する新しい活性化様式の解明, 平井 宏和, 「統合脳」冬のシンポジウム, 12 Dec. 2008
• A PKCγ mutation in spinocerebellar ataxia type 14 impairs developmental　elimination of climbing fiber synapses from Purkinje cells in vivo, Hajime Horiuchi, Anton Shuvaev, Masae Iino1, Takahiro　Seki, Norio Sakai, and Hirokazu Hirai, 8th International Conference on Protein Phosphatases, 12 Nov. 2008, 群馬
• レンチウイルスベクターを用いた神経科学研究と遺伝子治療, 平井 宏和, 「生体調節シグナルの統合的研究」第3回合同シンポジウム, 17 Oct. 2008
• レンチウイルスベクターを用いたδ２グルタミン酸受容体欠損マウスのレスキュー, 飯塚 朗、三ツ村 一浩、飯野 昌枝、寅嶋 崇、小山 知穂、平井 宏和, 第31回日本神経科学大会, 10 Jul. 2008
• レンチウィルスベクターを用いたマウス小脳核神経細胞への遺伝子導入, 堀内 始、寅嶋 崇、高山 清彦、飯塚 朗、三ツ村 一浩、飯野 昌枝、小山 知穂、平井 宏和, 第31回日本神経科学大会, 09 Jul. 2008
• デルタ２グルタミン酸受容体の細胞内信号伝達経路の解明, 平井 宏和, 「統合脳」夏のワークショップ, 21 Aug. 2008
• Staggererマウスを用いた脊髄小脳変性症1型の分子病態解明の試み, 平井 宏和, 「運動失調症の病態解明と治療法開発に関する研究班」班会議, 14 Jan. 2010
• Lentiviral vector-mediated rescue of cerebellar ataxia in a mouse model of spinocerebellar ataxia, Hirokazu Hirai, 5th International Symposium on Genomic Medicine of CCH 2009, 31 Oct. 2009, Taiwan
• Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia, Hirokazu Hirai, 2009Annual Meeting of Chinese Medical Association-Taipei, 01 Nov. 2009, Taiwan
• 神経科学と脳疾患, 平井 宏和, 大連医科大学サマースクール, 02 Aug. 2009
• デルタ２グルタミン酸受容体のＮＴＤを介する新しい活性化様式の解明, 平井 宏和, 「統合脳」夏のワークショップ, 12 Aug. 2009
• Mechanisms that affect functions of cerebellar Purkinje cells in spinocerebellar ataxia type14, 平井 宏和, 群馬大学・秋田大学連携グローバルCOEプログラム国際シンポジウム, 24 Jun. 2009
• 遺伝性脊髄小脳変性症14型の病態解明, 平井 宏和, 第2回「情報と細胞機能」研究会, 14 Feb. 2009
• 運動失調症の病態解明と治療法開発に関する研究, 平井 宏和, 「運動失調症に関する調査研究班」班会議, 16 Jan. 2009
• レンチウイルスベクターを用いた脳機能解析－神経細胞種特異的な幼弱脳、成熟脳への高効率遺伝子発現の実際とその応用－, 平井 宏和, 平成22年度 生理学研究所 研究会 「シナプス可塑性の動作原理」, 10 Jun. 2010
• Lentiviral-vector-based gene therapy for amouse model of hereditary spinocerebellar ataxia, 平井 宏和, 「統合脳」地域巡回シンポジウム, 30 Aug. 2008
• レンチウイルスベクターの作製方法とその応用, 平井 宏和, 第33回組織細胞化学講習会, 06 Aug. 2008
• レンチウイルスベクターの進歩　－中枢神経系の病態生理解明と脳神経疾患の遺伝子治療への応用－, 平井 宏和、柚崎 道介, 第31回日本神経科学大会, 09 Jul. 2008
• 小脳顆粒細胞で合成される分泌タンパク質、Cbln1は小脳のシナプス形成と可塑性に不可欠である, 平井 宏和、渡辺 雅彦、柚崎 通介, 第83回 日本生理学会大会, 30 Mar. 2006
• HIV由来レンチウイルスベクターを用いたIn vivoマウス小脳プルキンエ細胞への遺伝子導入, 寅嶋 崇、山田 伸明、平井 宏和, 第83回 日本生理学会大会, 30 Mar. 2006
• 小脳神経細胞への遺伝子導入法開発と治療への応用, 平井 宏和, 第21回生理学Brain Clubセミナー　慶應義塾大学, 19 May 2006
• レンチウイルスベクターを用いたノックアウトマウス神経細胞への遺伝子レスキュー, 平井 宏和, 第４回 自閉症戦略会議, 15 Feb. 2006
• デルタ2型グルタミン酸受容体はCa2+透過性イオンチャネルとして機能しないCa2+ influx through δ2 glutamate receptors is not required for cerebellar functions, 掛川 渉、宮崎 太輔、平井 宏和、三品 昌美、渡辺 雅彦、柚崎 通介, 第29回日本神経科学大会, 20 Jul. 2006
• ウイルスベクターを用いた脊髄小脳変性症3型の遺伝子治療法開発, 平井 宏和、寅嶋 崇, 三谷財団研究報告会, 25 May 2006
• 小脳失調関連遺伝子の機能解明と治療に向けた標的遺伝子の導入技術開発, 平井 宏和, 独立行政法人科学技術振興機構　戦略的創造研究推進事業 研究成果報告会, 02 Feb. 2006
• 神経細胞への特異的遺伝子導入法を用いた神経変性疾患の研究, 平井 宏和, 横河電機・金沢大学ライフサイエンス懇談会, 24 Jan. 2006
• Virus-mediated gene transfer to Purkinje cells in vivo and its application to basic and translational research., 平井 宏和, RIKEN BSI Cerebellar Colloquim, 23 Feb. 2007
• デルタ２グルタミン酸受容体の細胞内信号伝達経路の解明, 平井 宏和, 文部科学省特定領域研究「統合脳」夏のワークショップ, 22 Aug. 2006
• ウイルスベクターを用いた小脳神経細胞への選択的遺伝子発現法の開発, 平井 宏和, Neuroscience Frontier Research Conference (NEFRE), 30 Jul. 2006
• ウイルスベクターの特徴を利用することで可能となる細胞特異的遺伝子発現－HIV由来レンチウイルスベクターを用いた小脳神経細胞への遺伝子発現法, 平井 宏和, 第29回日本神経科学大会, 21 Jul. 2006
• 海馬培養細胞における乳酸の利用とmonocarboxylate輸送体の発現Increasedutilization of lactate in rat cultured hippocampal cells, 櫻井 孝、明嵜 太一、高田 俊宏、横野 浩一、平井 宏和, 第29回日本神経科学大会, 19 Jul. 2006
• 小脳失調症関連遺伝子の機能解明と治療に向けた標的遺伝子の導入技術開発, 平井 宏和, 独立行政法人科学技術振興機構　戦略的創造研究推進事業　領域会議, 01 Jul. 2006
• 小脳変性ミュータントマウス（staggerer　マウス）のシナプス伝達障害 　平行線維－プルキンエ細胞間のシナプスについて, 細井　延武, 16 Nov. 2010
• Rescue of developmental defects in mice with cerebellar ataxia using lentiviral vectors , Hirai H., 第4回国際小脳学会, 18 Sep. 2011, Tokyo
• Mutant γPKC found in spinocerebellar ataxia type 14disrupts synapse elimination and long-term depression in Purkinje cells in vivo, Shuvaev AN,Horiuchi H,Seki T, Gennawan H,Irie T,Iizuka A,Skai N,Hirai H, 第34回日本神経科学大会　, 15 Sep. 2011, Yokohama
• Disruption of mGluR-mediated signaling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice, Hosoi N,Mitsumura K,Hirai H, 第34回日本神経科学大会　, 15 Sep. 2011, Yokohama
• 遺伝性脊髄小脳変性症の病態解明と遺伝子治療, 平井 宏和, 「運動失調症の病態解明と治療法開発に関する研究班」班会議, 13 Jan. 2011
• Rescue of degenerating neurons in the cerebellum by lentiviral vector-based gene transfer., Hirai H, 第17回日本遺伝子治療学会年次学術集会, 15 Jul. 2011, Fukuoka
• Kv3.3チャネルのミスセンス変異は小脳プルキンエ細胞の樹状突起発達不全と細胞死を引き起こす, 入江智彦、松崎泰教、高山清彦、関野祐子、平井 宏和, 第８９回日本生理学会大会, 30 Mar. 2012
• Disruption of climbing fiber synapse elimination and LTD expression in cerebellar Purkinje cells by mutant γPKC found in spinocerebellar ataxia type 14, Hirai H, Ataxia Investigators Meeting 2012, 13 Mar. 2012, San Antonio,USA
• 脊髄小脳変性症１４型変異PKCによる小脳シナプス機能変化, 中村　和裕、平井 宏和, 平成２３年度「運動失調症の病態解明と治療法開発に関する研究」班会議, 12 Jan. 2012
• Disruption of mGluR-mediated signaling at cerebellar parallel fiber-Purkinje cell synapses in staggerer mutant mice, Hosoi N,Mitsumura K,Hirai H, 第二回国際放射線神経生物学会, 12 Mar. 2011, Maebashi
• Mutant γPKC found in spinoserebellar ataxia type 14disrupts synapse elimination and long-term depression in Purkinje cells in vivo, Shuvaev AN,Horiuchi H,Seki T,Gennawan H,Irie T,Iizuka A,Skai N,Hirai H., 第二回国際放射線神経生物学会　, 12 Mar. 2011, Maebashi
• Slective defect of metabotropic glutamate receptor signaling at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice, Hirai H,Seki T,Sakai N , 2011 FAOPS Congress, 13 Sep. 2011, Taipei
• 小脳変性症マウスを用いたゲノム非挿入レンチベクターの長期遺伝子治療効果の検証, 高山　清彦、平井 宏和, 第５回グローバルCOE若手研究シンポジウム　, 30 Aug. 2011
• GABA-B receptor and type 1 metabotropic glutamate receptor (mGluR1) as therapeutic targets for hereditary spinocerebellar ataxia., Hirokazu Hirai, ION CHANNEL MODULATION SYMPOSIUM 2018, 20 Jun. 2018, England
• Minimal Purkinje Cell-Specific L7 Promoter Virally Available for Rodents and Non-Human Primates., Matsuzaki Yasunori, Nitta Keisuke, Konno Ayumu, Hirai Hirokazu, 第9回国際小脳学会シンポジウム, 17 May 2018, Taipei
• Combination of AAV-PHP.B.with a Cell Type-Specific Promoter Can Express a Transgene in a Cell Type-Specific Manner Throughout the Brain., Ayumu Konno, 第9回国際小脳学会シンポジウム, 17 May 2018, Taipei
• Mitigation of Progressive Cerebellar Symptoms of Spinocerebellar Ataxia by Enhancing Type 1 Metabotropic Glutamate Receptor Signaling, Hirokazu Hirai, 第9回国際小脳学会シンポジウム, 17 May 2018, Taipei
• ＧＰＣＲ（Ｇタンパク共役型受容体）クロストークを利用した脊髄小脳失調症１型（ＳＣＡ1）に対する治療可能性, 細井延武, 第95回日本生理学会大会, 30 Mar. 2018
• ウイルスベクター:わかりやすく基礎から先端まで, 平井 宏和, 第95回日本生理学会大会, 30 Mar. 2018
• Pros and cons of an AAV double infection method combined with the Tet system :An experimental study, Nobutake Hosoi, Masayuki Shichida, Ayumu Konno, Hirokazu Hirai, Neuroscience 2017, 12 Nov. 2017, Washington, D.C., USA
• Functional control of clonal microglia by photo-activated channelrhodopsin-green receiver (ChRGR),, Kenji Ono, Hiromi Suzuki, Ayumu Konno, Toru Ishizuka, Hirokazu Hirai, Hiromu Yawo, Makoto Sawada, 第40回日本神経科学大会, 20 Jul. 2017, 千葉県・幕張
• Regulation of the firing property in mature Purkinje cells by PKC γcontributes to the motor coordination., Masashi Watanabe, Nobutaka Takahashi, Ayumu Konno, Hirokazu Hirai., 第40回日本神経科学大会, 20 Jul. 2017, 千葉県・幕張
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology, Masashi Watanave, Chiaki Hoshino, Ayumu Konno, Yumi Fukuzaki, Yasunori Matsuzaki, Tohru Ishitani, Hirokazu Hirai, The 75th Fujihara Seminar, 01 Dec. 2018
• Mouse models of cerebellar ataxia using AAV-PHP.B, a capsid variant highly permeable to the blood brain barrier., Hirokazu Hirai, The 75th Fujihara Seminar, 03 Dec. 2018
• Production and pharmacological treatment of spinocerebellar ataxia type 3 model mice produced by AAV9 vectors, Chiaki Hoshino, Ayumu Konno, Masashi Watanave, Hirokazu Hirai, 第41回日本神経科学大会, 26 Jul. 2018, Koube
• Mitgation of spinocerebellar ataxia type 3 pathology by activation of RAR-related orphan receptor alpha., Masashi Watanave, Ayumu Konno, Chiaki Hoshino, Hirokazu Hirai, 第41回日本神経科学大会, 26 Jul. 2018, Koube
• Effect of glucocorticoids on chaperone-mediated autophagy and microautophagy, Masahiro Sato, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, 第41回日本神経科学大会, 27 Jul. 2018, 神戸
• Effect of D-cysteine on the dendritic development of cultured cerebellar Purkinje cells., Takahiro Seki, Masahiro Sato, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, 第41回日本神経科学大会, 26 Jul. 2018, 神戸
• Cell type-specific transgene expression throughout the brain by intravenous injection of AAV-PHP.B., Ayumu Konno, Yoichiro Shinohara, Keisuke Nitta, Chiaki Hoshino, Hirokazu Hirai, 第41回日本神経科学大会, 28 Jul. 2018, 神戸
• Viral vector-mediated identification of the L7 promoter region regulating Purkinje cell-specific expression, Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai, 第41回日本神経科学大会, 28 Jul. 2018, 神戸
• Progressive impairment of metabotropic glutamate receptor(mGluR) mediated signaling and carebellar synaptic plasticity in spinocerebellar ataxia type 1(SCA1) model mice., N Hosoi, AN Shuvaev, H Hirai, Neuroscience 2016, 12 Nov. 2016, サンディエゴ　ＵＳＡ
• A super simplified method for a purification of adeno-associated virus vector, Ayumu Konno, Hirai Hirokazu, 第42回日本神経科学大会(NEURO2019) , 25 Jul. 2019, 新潟県
• Production of neutralizing antibodies by systemically injected AAV-PHP.B completely blocks brain transduction by a second intravenous administration of AAV-PHP.B., Ayumu Konno, Hirai Hirokazu, 第25回日本遺伝子細胞治療学会, 22 Jul. 2019, 東京大学
• Protein kinase Cγ modulates Climbing Fiber - Purkinje cell synaptic transmission., Masashi Watanave, Nobutaka Takahashi, Ayumu Konno, Hirokazu Hirai, 第42回日本神経科学大会(NEURO2019), 25 Jul. 2019, 新潟県
• Yasunori Matsuzaki, Masami Tanaka, Sachiko Hakoda, Tatsuki Masuda, Ryota Miyata, Hirokazu Hirai, BBB-permeable properties of AAV-PHP.B are shared among diverse inbred strains of mice, 第42回日本神経科学大会(NEURO2019) , 25 Jul. 2019, 新潟県
• Development and Characterization of a New Inhibitory Neuron-specific Promoter, Chiaki Hoshino, Ayumu Konno, Ryosuke Kaneko, Hirokazu Hirai, 第42回日本神経科学大会(NEURO2019) , 25 Jul. 2019, 新潟県
• D-cysteine ameliorates improper dendritic development of primary cultured cerebellar Purkinje cells expressing mutant proteins causing spinocerebellar ataxias., Takahiro Seki, Masahiro Sato, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Hiroshi Katsuki, 第42回日本神経科学大会(NEURO2019) , 25 Jul. 2019, 新潟県
• Deletion of class Ⅱ ARFs in mice causes tremor by inhibiting Nav1.6 trafficking to cerebellar Purkinje cell axon initial segments., Tetsushi Sadakata, Nobutake Hosoi, Koji Shibasaki, Ayumu Konno, Hirokazu Hirai, Yasuki Ishizaki, Teiichi Furuichi, 第42回日本神経科学大会(NEURO2019) , 25 Jul. 2019, 新潟県
• 小脳プルキンエ細胞における古典的Cキナーゼαとγの発現量と生理機能, 平井　宏和, 第３９回日本生物学的精神医学会・第47回日本神経精神薬理学会　合同年会, 29 Sep. 2017
• AAV9 vector-mediated production of mouse model of spinocerebellar ataxia type 3 and electrophysiological analysis of that mouse. , Chiaki Hoshino, Masashi Watanabe, Ayumu Konno, Hirokazu Hirai , 第40回日本神経科学大会, 20 Jul. 2017, 千葉県幕張
• Generation of animal models of spinocerebellar ataxia via AAV9 vector-mediated gene transfer., Konno A, Matsuzaki Y, Hirai H, 第22回日本遺伝子細胞治療学会, 29 Jul. 2016, Tokyo
• Reversible conversion of the neuron-specific enolase promoter activity from neuron to astrocyte induced by neuroinflammation after brain injury., Yusuke Sawada, Ayumu Konno, Jun Nagaoka, Hirokazu Hirai, 第３９回日本神経科学大会, 22 Jul. 2016, Yokohama
• Impaired synaptic plasticity at cerebellar parallel fiber-Purkinje cell synapses in AAV vector-based mouse model of spinocerebellar ataxia type 3., Masashi Watanabe, Ayumu Konno, Hirokazu Hirai, 第３９回日本神経科学大会, 22 Jul. 2016, Yokohama
• Progressive impairment of cerebellar synaptic plasticity in spinocerebellar ataxia type 1, Nobutake Hosoi, Anton N. Shuvaev, Hirokazu Hirai, 第３９回日本神経科学大会, 22 Jul. 2016, Yokohama
• Probing expression pattern of a novel AAV double infection method combined with the Tet system and the glia specific GFAP promoter, Nobutake Hosoi, Masayuki Shichida, Ayumu Konno and Hirokazu Hirai, 10th FENS Forum of Neuroscience, 04 Jul. 2016, デンマーク
• シンポジウム「神経変性疾患の最前線2016」 運動の記憶を形成する細胞内シグナル－脊髄小脳変性症マウスを用いた解析と治療の可能性－ Signaling pathway required for motor memory formation-Studies using spinocerebellar ataxia model mice and the therapeutic perspective , 平井宏和、シュワエフ　アントン、細井延武, 第４６回日本神経精神薬理学会年会, 02 Jul. 2018, 韓国ソウル
• Generation of animal models of spinocerebellar ataxia by AAV9-mediated gene delivery, 今野　歩、松﨑泰教、平井宏和, 第９３回日本生理学会大会, 23 Mar. 2016, 北海道　札幌
• Inflammation-induced switch of the neuron-specific enolase promoter activity from Purkinje neuron to Bergmann glia, Yusuke Sawada, Ayumu Konno, Toshinori Ohtani, Nobutaka Takahashi, Yasunori Matsuzaki, Shoji Kishi, Hirokazu Hirai, 第６回国際放射線神経生物学会大会, 13 Feb. 2016, 長崎県
• AAV9 vector ？mediated production of animal models of spinocerebellar ataxia., Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai, 第６回国際放射線神経生物学会大会, 13 Feb. 2016, 長崎県
• キャリアパスセミナー 「これからの日本社会が求める博士人材」, 平井宏和, 包括型脳科学研究推進支援ネットワークの冬のシンポジウム　, 17 Dec. 2015
• 「間葉系幹細胞による脳内環境の維持および破綻からの回復メカニズムの解明」, 平井宏和 , 「新学術領域研究」脳内環境：恒常性維持機構とその破綻　平成２７年度夏のワークショップ　, 24 Sep. 2015
• Mechanisms underlying the maintenance of brain environment and rescue from the insult by mesenchymal stem cells., 平井宏和, 新学術領域研究・脳内環境恒常性維持機構とその破綻　平成２７年度冬の班会議, 07 Jan. 2016
• Early motor impairment without neurodegeneration is induced in mice with cerebellar expression of mutant transmembrane protein 240, which causes spinocerebellar ataxia type 21. , omoko Ohta, Takahiro Seki, Yuki Kibe, Yuki Kurauchi, Ayumu konno, Hirokazu Hirai, Akinori Hisatsune, Hiroshi Katsuki, , 20 Jul. 2017, 第40回日本神経科学大会
• Low concentration of a GABAb receptor agonist improves motor performance in spinocerebellar ataxia type 1 (SCA1) model mice., Nobutake Hosoi, Shuvaev N Anton, Hirokazu Hirai, 22 Jul. 2017, 第40回日本神経科学大会
• Rapamycin activates mammalian microautophagy. , Masahiro Sato, Takahiro Seki, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune,Hiroshi Katsuki., 第40回日本神経科学大会, 22 Jul. 2017, 千葉県幕張
• In vivo evaluation of efficacy of the shortened WPRE sequence in cerebellum., Ayumu Konno, Kazuma Hachisu, Rika terashima, Hirokazu Hirai , 第40回日本神経科学大会, 22 Jul. 2017, 千葉県幕張
• Symposium 3S06m　JNS-JSNP Joint Symposium Chairperson Bases, clinics, and drug development for substance dependence , Hirokazu Hirai, 第40回日本神経科学大会, 22 Jul. 2017, 千葉県幕張
• Regulation of cerebellar function by protein kinase C, Hirokazu Hirai, International Symposium of the Society for Research on the cerebellum and Ataxias, 25 May 2017, カナダ　マニトバ　ウィニペグ
• 成熟マウス小脳においてプロテインキナーゼCγは運動機能を制御する, 平井 宏和、高橋 伸卓、渡邊 将、今野歩, 第９４回日本生理学会大会, 30 Mar. 2017
• オルガネラ・オプトジェネティクス－細胞内Ca2+ダイナミクスの光制御, 五十嵐 敬幸、吉川 彩香、浅野 豪文、今野 歩、櫻木 繁雄、石塚 徹、平井 宏和、八尾 寛, 第９４回日本生理学会大会, 29 Mar. 2017
• 一般講演座長, 平井宏和, 第７回国際放射線神経生物学会大会, 09 Feb. 2017
• Identification and appreciation of novel antagonists of GPR173., Toshihiro Yanai, Anton N. Shuvaev, Ayumu Konno, Hirokazu Hirai, Aya Kurosawa, Tamio Saito, Shigeki Takeda, The 58th Annual Meeting of the Japanese Society for Neuroscience,, 11 Sep. 2015, 大宮
• Progressive impairment of cerebellar mGluR signaling in SCA1 model mice., Nobutake Hosoi, Hirokazu Hirai, 第３８回日本神経科学大会, 30 Jul. 2015, 神戸
• A marmoset model of spinocerebellar ataxia type 3 generated using AAV vectors., Ayumu Konno, Yasunori Matsuzaki, Yoichiro Shinohara, Hirokazu Hirai, 第３８回日本神経科学大会, 28 Jul. 2015, 神戸
• Evaluation of glial tropism using novel AAV double infection method combined with the Tet system and truncated GFAP promoter., Masayuki Shichida, 第３８回日本神経科学大会, 28 Jul. 2015, 神戸
• Protein kinase Cα has potential to eliminate climbing fiber synapses from developing Purkinje cells in the cerebellum., Nobutaka Takahashi, Anton N. Suvaev, Yasunori Matsuzaki, Hirokazu Hirai, 第３８回日本神経科学大会, 28 Jul. 2015, 神戸
• Therapeutic potential of mesenchymal stem cells from spinocerebellar ataxia type 1 knock-in mice., 澤田悠輔、今野　歩、松﨑泰教、Fathul Huda、高橋伸卓、平井宏和, 第３８回日本神経科学大会, 30 Jul. 2015, 神戸
• Gene and stem cell therapies against polyglutamine diseases, Hirokazu Hirai, 第５６回日本神経学会学術大会, 20 May 2015, 新潟
• 神経疾患に対する幹細胞治療, 平井宏和 , 第92回日本生理学会大会, 22 Mar. 2015
• マーモセットにおけるアストロサイト特異的プロモーターの導入遺伝子発現, 篠原洋一郎, 第92回日本生理学会大会, 23 Mar. 2015
• 間葉系幹細胞由来神経栄養因子の脊髄小脳変性症に対する治療効果検討, 須藤奈々, 第92回日本生理学会大会, 23 Mar. 2015
• Disruption of metabotropic glutamate receptor signaling in Purkinje cells expressing a mutant SCA1 gene. , Anton N. Shuvaev, Nobutake Hosoi, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• Producing animal models of spinocerebellar ataxia type 3 via a viral vector-mediated gene delivery., Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• Progressive impairment of mGluR-mediated synaptic transmission in SCA1 model mice. , Nobutake Hosoi, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• 短縮型マウスGFAPプロモーターとTet systemを組み合わせたAAV二重感染法による遺伝子発現のグリア特異性の検討, 七田真之、細井延武、今野　歩、平井宏和, 第5回国際放射線神経生物学会大会, 21 Feb. 2015
• Protein Kinase Cα has potential to eliminate climbing fiber synapses from developing Purkinje cells in the cerebellum., Nobutaka Takahashi, Anton N. Shuvaev, Yasunori Matsuzaki, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• Intrathecal injection of mesenchymal stem cells ameliorates cerebellar pathology of spinocerebellar ataxia type 1 mice., Serina Matsuura, Kazuhiro Nakamura, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• Mesenchymal stem cell-conditioned medium alleviates the peripheral pathology in spinocerebellar ataxia type 1-knockin mice., Nana Suto, Kazuhiro Nakamura, Hirokazu Hirai, 第5回国際放射線神経生物学会大会　, 21 Feb. 2015, 群馬県高崎市
• Fusion of mesenchymal stem cells exclusively with “degenerating” cerebellar neurons in spinocerebellar ataxia type 1 model mice., Fathul Huda, Yiping Fan, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry K.Y. Chan, Hirokazu Hirai , 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• One-year follow-up of transgene expression by integrase-defective lentiviral vectors and therapeutic potential in polyglutamine disease model mice., Yasunori Matsuzaki, Hanae Saida, Kiyohiko Takayama, Akira Iizuka, Ayumu Konno, Shigeru Yanagi, Hirokazu Hirai, 第5回国際放射線神経生物学会大会, 21 Feb. 2015, 群馬県高崎市
• 間葉系幹細胞による脳内環境の維持および破綻からの回復メカニズムの解明, 平井宏和, 文科省「新学術領域研究」脳内環境：恒常性維持機構とその破綻平成２６年度冬の班会議, 08 Jan. 2015
• アデノ随伴ウィルスによる小脳全域への遺伝子導入を介した脊髄小脳変性症３型モデル動物の作出, 今野　歩, 包括型脳科学研究推進ネットワーク冬のシンポジウム, 13 Dec. 2014
• Intrathecal injection of weseachywal stem cells ameliorates neurodegeneration of spinocerebellar ataxia type1 maice., Serina Matsuura, 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering(GUMI&AMDE2014), 05 Dec. 2014, 群馬県桐生市
• Production of animal models of spinocerebellar ataxia type 3 by a viral ？vector-mediated gene delivery., Ayumu Konno, Yasunori Matsuzaki, Naoya Ohta, Hirokazu Hirai, 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering(GUMI&AMDE2014), 05 Dec. 2014, 群馬県桐生市
• Small β-barrel protein accumulation., Kazuhiro Nakamura, Tsuyoshi Takahashi, 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Engineering(GUMI&AMDE2014), 05 Dec. 2014, 群馬県桐生市
• 脊髄小脳変性症１型モデルマウスにおけるmGouRを介したシナプス伝達の進行性異常, 細井延武、平井宏和, 生理学研究所研究会「シナプス・神経ネットワークの機能ダイナミクス」, 02 Dec. 2014
• 「Synaptic regulation in the cerebellum and motor control」Impairment of synaptic transmission that induces cerebellar ataxia and the underlying molecular mechanisms., Hirokazu Hirai, 第37回日本神経科学学会大会, 11 Sep. 2014, 横浜市
• Takenori Kotani, Yoji Murata, Hirokazu Hirai, Hidenori Suzuki, Takashi Matozaki Functional analysis of protein tyrosine phosphatase Shp2 in the adult forebrain neurons. , Hiroshi Ohnishi, Shinya Kusakari, Fumihito Saitow, Miho Hashimoto, Yasunori Matsuzaki, 第37回日本神経科学学会大会, 11 Sep. 2014, 横浜
• インテグレースを欠損させたレンチウイルスベクターによる一年間の遺伝子発現の経過観察と遺伝性神経変性疾患モデルマウスを用いた遺伝子治療での有効性の検討, 松﨑泰教、齊田英恵、高山清彦、飯塚　朗、今野　歩、柳　茂、平井宏和, 第37回日本神経科学学会大会, 13 Sep. 2014
• AAVによる遺伝子導入を介した脊髄小脳変性症３型モデルマウスの作出, 今野　歩、平井宏和, 第37回日本神経科学学会大会　, 13 Sep. 2014
• 間葉系幹細胞による脳内環境の維持および破綻からの回復メカニズムの解明, 平井宏和、中村和裕、今野　歩, 文部科学省科学研究費補助金【新学術領域研究】平成２６年度夏のワークショップ, 24 Jul. 2014
• Abnormalities of metabotropic glutamate receptor (MGLUR)-mediated signaling at cerebellar parallel fiber-purkinje cell synapses in spinocerebellar ataxia type 1(SCA1)model mice., Nobutake Hosoi, Hirokazu Hirai, 9th Federation of European Neuroscience Societies, 09 Jul. 2014, イタリア　ミラノ
• Distinct transduction profiles resul ting from direct cortical,intrathecal or intravenous injection of AAV9 in the CNS., Fathul Huda, Ayumu Konno, Yasunori Matsuzaki, Hanna Goenawan, Koichi Miyake, Takashi Shimada, Hirokazu Hirai., 9th Federation of European Neuroscience Societies, 07 Jul. 2014, イタリア　ミラノ
• Molecular mechanisms and potential therapies of the spinocerebellar ataxia and the future perspective of the clinical application., Hirokazu Hirai, International congress on Neuroscience, 20 Jul. 2014, ロシア　クラスノヤルスク
• シナプス刈り込みにおける逆行性シグナルの役割, 上阪直史、内ヶ島基政、三國貴康、平井宏和、渡辺雅彦、狩野方伸, 第91回日本生理学会大会, 16 Mar. 2014
• 放射線の脳組織への影響 From bed to bench, 平井宏和, 第4回国際放射線神経生物学会大会, 17 Jan. 2014
• 小脳の再生－発達不全から変性疾患まで－, 平井宏和, 2013年度　小脳研究会学術集会・総会, 08 Jan. 2014
• Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release., 三木崇史、平井宏和、高橋智幸, 2013シナプス研究会「シナプス・神経ネットワークの機能ダイナミクス」, 12 Dec. 2013, 愛知県岡崎市
• Staggererマウスにおけるプルキンエ細胞のmGluRを介した応答は発達期のRORαを必要とする, 飯塚　朗、松﨑泰教、今野　歩、平井宏和, 2013シナプス研究会「シナプス・神経ネットワークの機能ダイナミクス」, 13 Dec. 2014
• Identification of retrograde signaling molecules required for developmental synapse elimination in the cerebellum by an RNAi-based approach., Uesaka N, Mikuni T, Hirai H, Kano M, Neuroscience2013 , 07 Nov. 2013, USA
• Perturbation of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the rescue by intravascular administration of AAV9., Konno A. Shuvaev A, Yanagi S, Hirai H., 23rd　Neuropharmacology Conference, 07 Nov. 2013, USA
• Disruption of mGluR signaling in SCA3 model mice expressing mutant ataxin-3 and the partial restorationvia intravenous administration of AAV9., Konno A, Shuvaev A, Yanagi S, Hirai H., Neuroscience2013, 10 Nov. 2013, USA
• Development of Gene and Stem Cell Therapies Against Neurodegenerative Diseases,Focusing on Spinocerebellar Ataxia., Hirokazu Hirai, The Indonesian Neurological Association Congress,, 27 Oct. 2013, インドネシア
• The Indonesian Neurological Association Congress,, Hirokazu Hirai, 第86回日本生化学会大会, 13 Sep. 2013, 横浜
• 脊髄小脳変性症モデル動物作成による病態解明と先端的治療法開発, 平井宏和, 平成25年度刀城クラブ前橋支部総会講演会, 22 Aug. 2013
• Route of AAV9 vector introduction decides the distribution patterns of transduced cell in the cerebellum:Implication of gene therapy approaches for cerebellar disease., Huda F, Konno A, Matsuzaki Y, Goenawan H, Hirai H, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, 岡山県
• Generation of neurodegenerative disease model mice using the altered neuron-specific synapsim Ⅰpromoter., Matsuzaki Y, Oue M, Hirai H, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, 岡山県
• Disruption of metabotropic glutamate receptor signaling in Purkinje cells expressing a lentivirally transduced mutant SCA1., Anton S, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, 岡山県
• Robust and cell type-specific transgene expression by applying tetracycline-controlled system to AAV9., Yamaguchi T, Konno A, Miyake N, Miyake K, Shimada T, Hirai H, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, 岡山県
• Disruption of metabotropic glutamate receptor signaling and rescue throughintravasucular administration of AAV9 in a mouse model of spinocerebellar ataxia type 3., Konno A, Shuvaev A N., Miyake N, Miyake K, Yanagi S, ShimadaT, Hirai H., 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, 岡山県
• Progress of spinocerebellar ataxia research on pathology,model animals and gene/stem cell therapies. Toward clinical application., Hirai H, 第19回日本遺伝子治療学会学術集会　, 05 Jul. 2013, 岡山県
• 小脳抑制性シナプス前末端カルシウムチャネルサブタイプスイッチ機構, 三木崇史、平井宏和、高橋智幸, Neuro2013, 21 Jun. 2013
• Disruption of metabotropic glutamate receptor signaling in Purkinje cells expressing a lentivirally transduced mutant SCA1 gene., Anton Nikolaevich Shuvaev, Sato Y, Hanna Goenawan, Yanagihara D, Hirai H, Neuro2013, 21 Jun. 2013, 京都
• 中枢神経系の神経細胞特異的に導入遺伝子が発現する遺伝子組換マウスの作出と解析, 松﨑泰教、大上美穂、平井宏和, Neuro2013 , 20 Jun. 2013
• 脊髄小脳変性症３型マウスモデルにおけるmGluR1の機能不全とAAV9を用いた遺伝子治療によるその機能回復, 今野　歩、Shuvaev Anton、三宅紀子、三宅弘一、柳　茂、島田 隆、平井宏和, Neuro2013 , 20 Jun. 2013
• 脊髄小脳変性症にみられる変異型Kv3.3チャネルは、培養小脳プルキンエ細胞において細胞死と興奮性変化を引き起こす, 入江智彦、松﨑泰教、関野祐子、平井宏和, Neuro2013 , 20 Jun. 2013
• Leading edge of viral vectors that visualize/manipulate a specific network in the CNS 　 Development of viral vectors labeling a specific cell population in non-human primates and their application to generation of a neurodegenerative disease model , Hirokazu Hirai , 第３９回日本神経科学大会　20-22/7/2016, 20 Jul. 2016
• Generation of a marmoset model of spinocerebellar ataxia type 3 via AAV9 vector-mediated gene transfer, A Konno, Y Matsuzaki, H Hirai, Neuroscience 2016, 14 Nov. 2016, サンディエゴ　ＵＳＡ
• 脊髄小脳変性症13型における変異型Kv3.3チャネルは、培養小脳プルキンエ細胞において細胞死と興奮性変化を引き起こす, 入江智彦、松﨑泰教、関野祐子、平井宏和, 第90回日本生理学会大会, 29 Mar. 2013
• ウィルスベクターを利用した小脳プルキンエ細胞、バーグマングリア、あるいは介在ニューロン特異的、かつ効率的な遺伝子発現法―カテプシンK活性の調節及び細胞種特異的プロモーターの開発, 平井宏和, 第90回日本生理学会大会, 27 Mar. 2013
• 細胞培養法と細胞種特異的遺伝子導入法を用いたシナプス刈り込みのメカニズムの解明, 上坂直史、三國貴康、平井宏和、狩野方伸, 第90回日本生理学会大会, 27 Mar. 2013
• Modulation of lentiviral vector tropism in cerebellar Purkinje cells in vivo by a lysosomal cysteine protease cathepsin K, Hirokazu Hirai, International Synapse Research Workshop 2012, 09 Nov. 2012, 愛知県岡崎市
• Cranial Irradiation Induces Migration of Bone Marrow Derived Microglia (BMDM) to the Cerebellum in Adult C57BL/6 Mice., Noriyuki Okonogi, Kazuhiro Nakamura, Yoshiyuki Suzuki, Takuya Kaminuma, Nana Suto, Takashi Nakano, Hirokazu Hirai , American Society for Radiation Oncology, 28 Oct. 2012, USA
• Development of highly efficient and cell-type specific gene transfer into the cerebellum and its application to gene therapy., Hirokazu Hirai, Bandung Biomolecular Medicine Confrence2(, 05 Oct. 2012, インドネシア
• トランスジェニックマウスにおいて、マウス幹細胞ウィルスプロモーターは白血球とプルキンエ細胞選択的に遺伝子発現する, 平井宏和、大上美穂、松﨑泰教、鈴江一友, 第３５回日本神経科学大会, 20 Sep. 2012
• Lentivectorを用いたRORaによるプルキンエ細胞樹状突起発達障害のレスキューとその臨界期の検討, 飯塚　朗、松﨑泰教、今野　歩、細井延武、平井 宏和, 第３５回日本神経科学大会, 20 Sep. 2012
• AAV9の静脈注射による脊髄小脳変性症３型モデルマウスへの遺伝子治療の試み, 今野　歩、Shuvaev AN、三宅紀子、三宅弘一、柳　茂、島田隆、平井宏和, 第３５回日本神経科学大会, 19 Sep. 2012
• Impalrment of metabotropic glutamate receptor signaling in mouse Purkinje cells　expressing a mutant gene of spinocerebellar ataxia type1., Shuvaev AN, Yamato S, Hanna Goenovan, Yanagihara D, Hirai H, 第３５回日本神経科学大会, 18 Sep. 2012, 名古屋
• Modification of lentiviral tropism for Purkinje cells by cathepsin K released from HEK 293T cells., Hanna Goenawan, Hirai H., 第３５回日本神経科学大会　, 18 Sep. 2012, 名古屋
• 「博士号取得者がどうやって職を得るのか？―アカデミア以外の可能性―（若手のキャリアパスを考える」シンポジウム企画, 平井宏和, 包括型脳科学研究推進支援ネットワーク　夏のワークショップ, 27 Jul. 2012
• Cranial Irradiation Induces Migration of Bone Marrow-Derived Cells to the Cerebellum and their Differentiation into Microglia in Adult Mice., Noriyuki Okonogi, Kazuhiro Nakamura, Yoshiyuki Suzuki, Nana Suto, Kazutomo Suzue, Takuya Kaminuma, Takashi Nakano, Hirokazu Hirai, 11th International Stereotactic Radiosurgery Society Congress, 16 Jun. 2012, カナダ　トロント
• Disruption of mGluR-mediated signalling at cerebellar parallel fibre-Purkinje cell synapses in staggerer mutant mice., Hosoi N, Mitsumura K, Hirai H, 8th FENS FORUM of NEUROSCIENCE, 18 Jul. 2012, スペイン　バルセロナ
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning, Masashi Watanave,Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai, FAOPS2019 神戸, 30 Mar. 2019, 神戸
• Mouse strain-dependent BBB(blood-brain barrier)permeability of AAV-PHP.B, Yasunori Matsuzaki,Masami Tanaka, Sachiko Hakoda, Tatsuki Masuda, Ryota Miyata, Ayumu Konno, Hirokazu Hirai, FAOPS2019 , 31 Mar. 2019, 神戸
• TMEM240, a causative protein of spinocerebellar ataxia type 21, regulates intracellular lipid metabolism and morphology of cerebellar Purkinje cells. , Takahiro Seki, Masahiro Sato, Mutsumi Oshima, Ayumu Konno, Hirokazu Hirai, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki., 第40回日本神経科学大会, 21 Jul. 2017, 千葉県幕張
• In vivo evaluation of shortened version of neuron-specific enolase promoter, Hirokazu Hirai, 第７回国際放射線神経生物学会大会, 09 Feb. 2017
• Optimization of the neuron-specific enolase promoter for AAV vectors, Ayumu Konno, Yoichiro Shinohara, Toshinori Ohtani, Hirokazu Hirai, 第３９回日本神経科学大会, 22 Jul. 2016, Yokohama
• Progressive abnormalities in short-and long term synaptic plasticity and dendritic Ca2+ signals in spinocerebellar ataxia type 1 (SCA1) model mice., 細井延武、シュワエフ　アントン、平井宏和, 第９３回日本生理学会大会, 24 Mar. 2016, 北海道札幌
• Fusion of mesenchymal stem cells exclusively with degenerating cerebellar neurons in spinocerebellar ataxia model mice., Hirokazu Hirai, Yiping Fan, Ayumu Konno, Yasunori Matsuzaki, Nobutake Takahashi, Chan K.Y.Jerry, Huda Fathul., 第３８回日本神経科学大会, 29 Jul. 2015, 神戸
• 間葉系幹細胞による脊髄小脳変性症１型モデルマウスの治療, 中村和裕, 第92回日本生理学会大会, 22 Mar. 2015
• 間葉系幹細胞の髄腔内投与による脊髄小脳変性症１型モデルマウスの神経変性改善, 松浦瀬里奈, 第92回日本生理学会大会, 23 Mar. 2015
• 博士号を取得することで広がる多様な可能性 ―博士号を取ることで人生何が変わるのか―」 , 平井宏和, 包括型脳科学研究推進ネットワーク冬のシンポジウム, 13 Dec. 2014
• Sema3AとSema7Aによる逆行性シグナルがシナプス刈り込みを制御している, 上阪直史、内ヶ島基政、三國貴康、中澤敬信、中尾晴美、平井宏和、饗場　篤、渡辺雅彦、狩野方伸, 第37回日本神経科学学会大会, 11 Sep. 2014, 横浜
• Cerebellar transduction profiles after ssAAV9 injection via cortical, intrathecal or intravenous routes., Fathul Huda, Ayumu Konno, Yasunori Matsuzaki, Hanna Goenawan, Koichi Miyake, Takashi Shimada, Hirokazu Hirai, 第37回日本神経科学学会大会, 12 Sep. 2014, 横浜
• 小脳性運動失調とシナプス伝達異常, 細井延武、平井宏和, 第91回日本生理学会大会, 16 Mar. 2014
• 脊髄小脳変性症1型モデルマウス中枢及び抹消神経障害に対する間葉系幹細胞の治療効果, 中村和裕、平井宏和, 第91回日本生理学会大会, 17 Mar. 2014
• 「若手のキャリアプランにおけるテニュアトラック制度の可能性」シンポジウム企画, 平井宏和, 包括型脳科学研究推進支援ネットワーク　夏のワークショップ, 30 Aug. 2013
• Distinct transgene expression profiles in the cerebellum by the direct cortical,intrathecal and intravenous injection of AAV9:Implication of gene therapy for cerebellar diseases., Fathul Huda, Konno A, Matsuzaki Y, Hanna Goenawan, Hirai H, Neuro2013 , 20 Jun. 2013, 京都
• Kv3.3チャネルのミスセンス変異は小脳プルキンエ細胞の樹状突起発達不全と細胞死を引き起こす , 入江智彦、松崎泰教、関野祐子、平井宏和, 第３５回日本神経科学大会, 18 Sep. 2012
• The effect of orally-administered baclofen on spinocerebellar ataxia type 3(SCA3)model mice, Nobutake Hosoi, Hirokazu Hirai, FAOPS2019, 30 Mar. 2019, 神戸
• Protein Kinase Cα has potential to eliminate climbing fiber synapses from developing Purkinje cells in the cerebellum., Nobutaka Takahashi, Anton N.Shuvaev, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai, 第６回国際放射線神経生物学会大会, 13 Feb. 2016, 長崎県

Research Projects

• 01 Apr. 2018, 31 Mar. 2021, 18H02521
• Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing, Hirai Hirokazu; HOSOI Nobutake; KONNO Ayumu; MATSUZAKI Yasunori, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 01 Apr. 2016, 31 Mar. 2018, In this research, we aimed to establish a technique that allows elimination of a disease-causing gene from specific cell populations in the brain, using adeno-associated virus (AAV) vectors in combination with CRISPR/Cas9 system. Initially, we characterized neuron-specific, astrocyte-specific and cerebellar Purkinje cell-specific promoters available for AAV vector-mediated transgene expression. The results were published in 3 papers. Then, using the AAV vectors, we examined whether a gene responsible for developmental defects of the brain could be knocked out from Purkinje cells by CRISPR/Cas9 system. The results showed successful removal of the gene from around two thirds of Purkinje cells., 16K15477

  対象リソースIRI
• Elucidation of cellular and nuclear signals that regulate motor learning, Hirai Hirokazu; HOSOI Nobutake; KONNO Ayumu; MATSUZAKI Yasunori, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, 01 Apr. 2015, 31 Mar. 2018, Decrease of several genes including transient receptor potential cation channel type 3 (TRPC3), inositol trisphosphate (IP3) receptor and Homer protein homolog 3 (HOMER3) were found in the cerebellum of spinocerebellar ataxia type 1 (SCA1) knock-in mouse. We identified retinoid-related orphan receptor α (RORα), which is a transcription factor that could regulate expression of those genes. Moreover, we found that a gene “X” is increased more than 3 times in SCA1 knock-in mice 3 h after treatment with baclofen and rotarod training. Since haploinsufficiency of the gene “X” is known to cause mental retardation, upregulation of the gene “X” may play a key role in baclofen-induced improvement of motor learning in SCA1 mice., 15H04254

  対象リソースIRI
• Action potential regulation at the node of Ranvier and perineuronal nets' regulation of GABAergic transmission in the deep cerebellar nuclei, Hirono Moritoshi; MISONOU Hiroaki; WATANABE Shoji; YANAGAWA Yuchio; HIRAI Hirokazu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Doshisha University, 01 Apr. 2015, 31 Mar. 2018, Regulation of axonal action potentials (APs) by K+ channels is important in the CNS. Application of BK channel blockers and T-type Ca2+ channel blockers to axons of cerebellar Purkinje cells (PCs) increased the failure rate of antidromic APs, suggesting that paranodal BK channels support high-fidelity firing at the node of Ranvier. Perineuronal nets (PNNs) are the extracellular matrix of neurons and are found around large neurons in the deep cerebellar nuclei (DCN). Enzymatic PNN depletion of DCN neurons reduced the paired-pulse ratio of inhibitory postsynaptic currents (IPSCs) and increased the miniature IPSC frequency without changing the amplitude, suggesting that PNN depletion enhances GABA release from presynaptic terminals. Mice having received the enzyme in the interpositus nuclei exhibited a higher conditioned response rate in delay eyeblink conditioning than control mice, suggesting that PNNs suppress GABAergic transmission and impede motor learning in the adult cerebellum., 15K06788

  対象リソースIRI
• Functional roles of glial ATP receptors in neuron-glia interaction, HOSOI Nobutake; KONNO Ayumu; HIRAI Hirokazu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2013, 31 Mar. 2017, Similarly to neurons, glial cells have ATP receptors and may play an active role in neuronal information processing. Originally, in order to examine functional roles of cerebellar glial ATP receptors, I tried to knockdown glial ATP receptors using microRNA-mediated gene silencing technique and it did not work. However, while I tried to express transgenes selectively in cerebellar glial cells with adeno-associated virus (AAV) vectors, I managed to develop a method in which larger transgenes can be expressed in glial cells, compared to the usual usage of AAV vectors. The pros and cons of this method were examined experimentally, and I am preparing for publishing the results., 25430003

  対象リソースIRI
• 01 Apr. 2014, 31 Mar. 2016, 26111701
• Comprehensive Brain Science Network, Kimura Minoru; Tanji Jun; Takada Masahiko; Nakamura Katsuki; Ohtsuka Toshihisa; Aoki Shigeki; Takao Hidemasa; Shimoji Keigo; Goto Masami; Yoshiura Takashi; Nakata Yasuhiro; Abe Osamu; Masumoto Tomohiko; Tokumaru Aya; Matsumura Akira; Kirino Eiji; Terada Hitoshi; Sato Noriko; Kasai Kiyoto; Hashimoto Ryota; Niwa Shin-ichi; Kato Tadafumi; Suzuki Michio; Shuji Iritani; Nemoto Kiyotaka; Tomita Hiroaki; Murayama Shigeo; Akatsu Hiroyasu; Takao Masaki; Saito Yuko; Bito Haruhiko; Yoshimura Yumiko; Matsuzaki Masanori; Furuta Toshiaki; Okado Haruo; Saito Izumu; Kaibuchi Kozo; Hasegawa Masato; Aiba Atsu; Shiina Nobuyuki; Igarashi Michihiro; Tomoki Nishioka; Watanabe Masahiko; Koike Masato; Sakagami Hiroyuki; Shigemoto Ryuichi; Fukazawa Yugo; Sakimura Kenji; Mori Hisashi; Mishina Masayoshi; Kobayashi Kazuto; Yanagawa Yuchio; Uemura Tadashi; Ishihara Takeshi; Nose Akinao; Iino Yuichi; Miyakawa Tsuyoshi; Takao Keizo; Mushiake Hajime; Katayama Norihiro; Tanaka Tetsu; Inoue Kazuhide; Okabe Shigeo; Kano Masanobu; Fujiyama Fumino; Isa Tadashi; Kageyama Ryoichiro; Fujita Ichiro; Yoshida Akira; Nishikawa Toru; Nukina Nobuyuki; Fukai Tomoki; Iwatsubo Takeshi; Yamamori Tetsuo; Okazawa Hitoshi; Tanaka Keiji; Kakigi Ryusuke; Tsuda Ichiro; Kitazawa Shigeru; Doya Kenji; Takahashi Ryosuke; Ikenaka Kazuhiro; Sobue Gen; Hasegawa Toshikazu; Ota Jun; Saitoe Minoru; Kadomatsu Kenji; Kida Satoshi; Manabe Toshiya; Tomita Taisuke; Iwata Atsushi; Murakami Ikuya; Tsutsui Ken-ichiro; Hanakawa Takashi; Hirai Hirokazu; Mima Tatsuya; Isomura Yoshikazu; Samejima Kazuyuki; Hoshi Eiji; Miyata Mariko; Yuzaki Michisuke; Tanaka Masaki; Fukata Masaki; Suzuki Kyoko; Kuba Hiroshi; Masu Masayuki; Kinoshita Makoto; Sugihara Izumi; Shirane Michiko; Yamamoto Nobuhiko; Nishijo Hisao; Nambu Atsushi; Takumi Toru; Yamashita Toshihide; Sakurai Takeshi; Tamamaki Nobuaki; Hata Yoshio; Harada Akihiro; Ozaki Norio; Sakai Katsuyuki; Kubo Yoshihiro; Nakazawa Takanobu; Tanaka Kenji; Takei Nobuyuki; Hitoshi Seiji; Takahiroa. Kato; Kato Fusao; Shirao Tomoaki; Taira Masato; Okano Hideyuki; Sekino Yuko; Okamoto Yasumasa; KOMATSU Hidehiko; Miyata Takaki; Takahashi Yoshiko; Nishida Shinya; Tominaga Makoto, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Center for Novel Science Initatives, National Institutes of Natural Sciences, 01 Apr. 2010, 31 Mar. 2016, The Comprehensive Brain Science Network (CSBN) provided individual researches supported by Grant-in-Aid for Scientific Research with cutting-edge resources and technologies, such as model animals, postmortem brain tissue, optical technologies for imaging and manipulation, virus vectors and more. Support covered researches on neuron-specific genes and molecules, synapse, network system, brain functions in disease states and neuro-computation. Special support was directed to collaboration between different fields. Workshop was held to have joint symposia among fields of peoples, to have a special session to let neuroscience community members share knowledge of how current researches are supported in Japan and discuss about future. Graduate students and postdoctoral fellows were supported to visit other laboratories of different field in Japan and abroad and learn disciplines, and award those who presented high quality work the CBSN Prize. These supports promoted break through from conventional approaches and publication of a number of papers with very high quality., 221S0003

  対象リソースIRI
• Long-term oral administration of the NMDA receptor antagonist memantine extends life span in spinocerebellar ataxia type 1 knock-in mice., IIZUKA Akira; HIRAI Hirokazu; NAKAMURA Kazuhiro; KONNO Ayumu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Gunma University, 01 Apr. 2013, 31 Mar. 2015, Spinocerebellar ataxia type 1 (SCA1) is a progressive neurodegenerative disease caused by abnormal Sca1 gene. Although the mechanisms underlying the symptoms of SCA1 have not been determined, aberrant neuronal activation contributes to the neurodegenerative disorder. Here we examined the potential involvement of extrasynaptic N-methyl-d-aspartate receptor (NMDAR) activation in the pathogenesis of SCA1 by administering memantine, NMDAR antagonist, in SCA1 knock-in (KI) mice. Memantine was administered orally to the SCA1 KI mice from 4 weeks of age until death. The treatment significantly prolonged the life span of SCA1 KI mice. Furthermore, memantine significantly suppressed the loss of Purkinje cells in the cerebellum and motor neurons in the dorsal motor nucleus of the vagus. These findings support the contribution of aberrant activation of extrasynaptic NMDARs to neuronal cell death in SCA1 KI mice and suggest that memantine may also have therapeutic benefits in human SCA1 patients., 25830046

  対象リソースIRI
• Establishment and application of lentivector-based production of gene-rescue mouse for exploring gene functions, HIRAI Hirokazu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (S), Grant-in-Aid for Young Scientists (S), Gunma University, 2007, 2011, 19670003

  対象リソースIRI
• 2008, 2009, 20021004
• 2006, 2007, 18021014
• Genetic analyses of motor ataxia mutant mice, MASUYA Hiroshi; WAKANA Shigeharu; HIRAI Hirokazu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), The Institute of Physical and Chemical Research, 2006, 2007, We worked out genetic mapping of five ataxia mutants derived from a large-scale mutagenesis program. As a result, M100612, M100651, M100718, M101243, M101479 were mapped on chromosomes 10, 2, 2, 11 and 6 respectively. Rotor rod analysis revealed that heterozugotes of four of five mutants showed obvious defect on motor coordination except for M101479. We worked out detailed analyses on M100651 which shows obvious ataxia and dilution of coat color. The cerebellum shows no morphological change of neuronal cells and their alignments. The cerebellum also showed any abnormalities in electrophysiologic analysis of the cerebellum. We worked out fine mapping analysis of M100651 with 591 progeny from the backcross ( (C57FIL/6J x DBA/2J)F1-M100651/+ x DBA/2J). As a result, M100651 was mapped on 7.2Mb (7152197bp) interval between genetic markers D21Mit484 (118399166-118399277bp) and D2Mit398 (125551330-125551474). We have searched candidate gene for M100651 mutation with a web-based knowledge base search system, PosMed (http://omicspace.riken.jp/PosMed/). A candidate gene for Hermansky-Pudlak Syndrome, Pldn is one of the candidate of M100651., 18500337
• 2003, 2007, 15082202
• Project to prove a link between phosphorylation of one amino-acid in glutamate receptors and motor learning, HIRAI Hirokazu; YANAGIHARA Dai, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), 2005, 2006, Tropism of lentiviral vectors for Purkinje cells of a mouse in vivo is influenced by cultivating condition of HEK293T cells, host cells for viral production. The tropism for Purkinje cells is high when the pH of the culture medium is >7.2, whereas the lentiviral vectors produced in the medium with the pH of <7.0 has high tropism for Bergmann glia. We aimed to produce gene-modified mice in which phosphorylation of GluR2 Ser880 is impaired specifically in Purkinje cells. This is attained by crossing 2 different transgenic mice; A mouse expressing L7-rtTA and that express GluR2 K882A under the control of tetracycline-responsive (TRE) promoter. Expression of rtTA in the former mouse is driven by Purkinje-cell-specific L7 promoter. The transgenic mouse having both transgenes expresses GluR2 K882A only when doxycycline is administered through water and food. We obtained 6 lines of mice with L7-rtTA transgene, in which only 2 lines showed rtTA expression in Purkinje cells. While 4 lines of mice with TRE promoter-GluR2 K882 and 3 lines of mice with TRE promoter-wild-type GluR2 were obtained. Now we are increasing the number of those mice for crossing them with L7-rtTA mice., 17300100
• 2005, 2006, 17650106
• 2005, 2006, 17659367
• 1999, 2000, 11780588
• 1998, 1999, 10878151
• 1997, 1998, 09780752