Researcher Profile and Settings

Researcher

• Name

  TAKAHASHI Akihisa

Profile and Settings

• Name

  Takahashi, Akihisa

Alternate Names

• Akihisa Takahashi

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Organization for Heavy Ion Medical Promotion Heavy Ion Medical Center, Professor
• Gunma University, Organization for Heavy Ion Medical Promotion Heavy Ion Medical Center, Professor

Education

• Apr. 1978, Mar. 1981
• Apr. 1989, Mar. 1991, Tokyo Gakugei University, Graduate School of Education
• Apr. 1985, Mar. 1989, Tokyo Gakugei University, Faculty of Education
• Apr. 1981, Mar. 1984

Degree

• PhD
• PhD, Kyoto University, Mar. 2001

Association Memberships

• Radiation Research Society
• The Japan Radiation Research Society (JRRS)
• Japanese Society of Space Radiation Research (JSSRR)
• Japanese Association of Cancer Research (JACR)
• Japanese Society of Thermal Medicine (JSTM)
• International Society of Radiation Neurobiology (ISRN)
• International Association for the Sensitization of Cancer Treatment (IASCT)
• PTCOG Radiobiology Sub-committee

Research Experience

• Apr. 1991, Mar. 1995, Otsuka Pharmaceutical Co., Ltd., Otsuka Otsu Research Laboratories, Assistant Researcher
• Apr. 1995, Jun. 2001, Nara Medical University, Department of Biology, Assistant Professor
• Jan. 2011, Mar. 2015, Gunma University, Advanced Scientific Research Leaders Development Unit, Associate Professor
• Apr. 2015, 9999, Gunma University, Heavy Ion Medical Center, Professor
• Jul. 2001, Dec. 2010, Nara Medical University, Department of Biology, Lecturer

Joint research and hope theme

• Industry-academia Collaboration, Technical consulting:Possible, Joint Research:Possible, Others:Impossible

Actual results of the joint research and commissioned research

• Apr. 2017
• Apr. 2014, Mar. 2016
• Apr. 2011, Mar. 2014
• Apr. 2012, Mar. 2014
• Apr. 2014, Mar. 2017
• Apr. 2017
• Apr. 2016, Mar. 2017
• Apr. 2018, Mar. 2019
• Mar. 2017
• MOU between GHMC and Yeungnam University, Jun. 2017, Jun. 2022
• Sep. 2017, Mar. 2018
• Dec. 2017
• Jun. 2017, Mar. 2020
• Mar. 2017, Mar. 2022
• Apr. 2018
• MOU between GHMC and Prairie View A&M University, Sep. 2017, Sep. 2022
• Jul. 2012
• Jul. 2002, Mar. 2003
• Jul. 1998, Mar. 2000
• Sep. 2017
• Apr. 2017

Research Activities

Research Areas

• Life sciences, Radiology

Research Interests

• Space biology
• Hyperthermic biology
• Radiation biology

Research Themes

• Elucidation of molecular mechanisms for radiation-induced cellular responses, Radiation,　DNA damage, repair, cell death, Personal, 2011, 2015, Radiation Science, JST Target Oriented Research for Embryonic Science and Technology (TOREST)
• Biological effect of space radiation, Domestic Collaboration, 2015, -, Radiation/Chemical Substance Influence Science, Grant-in-Aid for Scientific Research

Published Papers

• Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice, Kenshi Suzuki, Chizuru Tsuruoka, Takamitsu Morioka, Hitomi Seo, Mari Ogawa, Ryosuke Kambe, Tatsuhiko Imaoka, Shizuko Kakinuma, Akihisa Takahashi, Mar. 2024, Life Sci Space Res (Amst), 41, 202, 209, Scientific journal

  DOI
• Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity, Polina Malatesta, Konstantinos Kyriakidis, Megumi Hada, Hiroko Ikeda, Akihisa Takahashi, Premkumar Saganti, Alexandros Georgakilas, Ioannis Michalopoulos, Jan. 2024, Biomolecules, 14, 1, 88, Scientific journal

  DOI
• Partial liver irradiation in rats induces the hypertrophy of non-irradiated liver lobes through hepatocyte proliferation, Takuya Adachi, Yukari Yoshida, Kei Shibuya, Ken Sato, Yuichi Yamazaki, Satoru Kakizaki, Toshio Uraoka, Akihisa Takahashi, Jul. 2023, J Radiat Res, 64, 693, 701, Scientific journal

  DOI
• Synthetic torpor protects rats from exposure to accelerated heavy ions, Anggraeini Puspitasari, Fabio Squarcio, Martina Quartieri, Cristina Totis, Timna Hitrec, Akihisa Takahashi, Yukari Yoshida, Kenji Hanamura, Tomoko Yako, Matteo Cerri, Palma Simoniello, Marco Durante, Walter Tinganelli, 30 Sep. 2022, Sci Rep ., 12, 1, 16405, Scientific journal

  DOI
• A new type of simulated partial gravity apparatus for rats based on a pully-spring system, Shenke Zhang, Takuya Adachi, Shengli Zhang, Yukari Yoshida, Akihisa Takahashi, 31 Aug. 2022, Front Cell Dev Biol ., 10, 965656, Scientific journal

  DOI
• Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Zhenlin Ju, Tamlyn N. Thomas, Yi-Jen Chiu, Sakuya Yamanouchi, Yukari Yoshida, Jun-ichi Abe, Akihisa Takahashi, Jing Wang, Keigi Fujiwara, Megumi Hada, 30 May 2022, Int J Mol Sci, 23, 11, 6127, Scientific journal

  DOI
• Th balance related host genetic background affects the therapeutic effects of combining carbon-ion radiotherapy with dendritic cell immunotherapy, Liqiu Ma, Yoshimitsu Sakamoto, Ken Ando, Hidetoshi Fujita, Akihisa Takahashi, Tsuguhide Takeshima, Hiromi Otsuka, Daniel K Ebner, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa, 03 Nov. 2021, Int J Radiat Oncol Biol Phys, 112, 3, 780, 789, Scientific journal

  DOI
• The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Sakuya Yamanouchi;Takuya Adachi;Yukari Yoshida;Jordan Rhone;Jian-Hua Mao;Keigi Fujiwara;Premkumar B. Saganti;Akihisa Takahashi;Megumi Hada, Jul. 2021, Biological Sciences in Space, Scientific journal
• Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with a partial gravity environment, Shenke Zhang, Daishin Ueno, Takashi Ohira, Hisashi Kato, Tetsuya Izawa, Sakuya Yamanouchi, Yukari Yoshida, Akihisa Takahashi, Yoshinobu Ohira, Jun. 2021, Frontiers in Cell and Development Biology, Scientific journal
• Combined-environment simulator for low-dose-rate radiation and partial gravity of Moon and Mars, Akihisa Takahashi; Sakuya Yamanouchi; Kazuomi Takeuchi; Shogo Takahashi; Mutsumi Tashiro; Jun Hidema; Atsushi Higashitani; Takuya Adachi; Shenke Zhang; Fady Nagy Lotfy Guirguis; Yukari Yoshida; Aiko Nagamatsu; Megumi Hada; Kunihito Takeuchi; Tohru Takahashi; Yuji Sekitomi, Nov. 2020, Life, 10, 11, 274, 274, Scientific journal

  DOI
• Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations, Yamanouchi Sakuya;Rhone Jordan;Mao Jian-Hua;Fujiwara Keigi;Saganti Premkumar B;Takahashi Akihisa;Hada Megumi, 10 Sep. 2020, Life (Basel), 10, 9, 187, 187

  DOI
• Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways., Ito Soichiro S;Nakagawa Yosuke;Matsubayashi Masaya;Sakaguchi Yoshihiko M;Kobashigawa Shinko;Matsui Takeshi K;Nanaura Hitoki;Nakanishi Mari;Kitayoshi Fumika;Kikuchi Sotaro;Kajihara Atsuhisa;Tamaki Shigehiro;Sugie Kazuma;Kashino Genro;Takahashi Akihisa;Hasegawa Masatoshi;Mori Eiichiro;Kirita Tadaaki, 16 Jul. 2020, The Journal of Biological Chemistry, 295, 37, 12946, 12961

  DOI
• Correction: Oh, J.Y., et al. Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells, Cancers 2019, 11, 1812., Oh Ju Yeon;Kim Eun Ho;Lee Yeon-Joo;Sai Sei;Lim Sun Ha;Park Jang Woo;Chung Hye Kyung;Kim Joon;Vares Guillaume;Takahashi Akihisa;Jeong Youn Kyoung;Kim Mi-Sook;Kong Chang-Bae, 26 May 2020, Cancers (Basel), 12, 6

  DOI
• Characterization of a novel murine colon carcinoma subline with high-metastatic activity established by in vivo selection method., Liqiu Ma; Yoshimitsu Sakamoto; Akinori Kanai; Hiromi Otsuka; Akihisa Takahashi; Kazuhiro Kakimi; Takashi Imai; Takashi Shimokawa, 18 Apr. 2020, International Kournal of Molecular Sciences, 21, 8, 2829, Scientific journal

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• Carbon-ion beam irradiation alone or in combination with zoledronic acid effectively kills osteosarcoma cells, Kim Eun Ho;Kim Mi-Sook;Takahashi Akihisa;Suzuki Masao;Vares Guillaume;Uzawa Akiko;Fujimori Akira;Ohno Tatsuya;Sai Sei, 16 Mar. 2020, Cancers (Basel), 12, 3, 698, 698, Scientific journal

  DOI
• Synergistic autophagy effect of miR-212-3p in zoledronic acid-treated in vitro and orthotopic in vvo models and in patient-derived osteosarcoma cells, Oh Ju Yeon;Kim Eun Ho;Lee Yeon-Joo;Sai Sei;Lim Sun Ha;Park Jang Woo;Chung Hye Kyung;Kim Joon;Vares Guillaume;Takahashi Akihisa;Jeong Youn Kyoung;Kim Mi-Sook;Kong Chang-Bae, 18 Nov. 2019, Cancers (Basel), 11, 11, 1812, 1812, Scientific journal

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• Anti-metastatic benefits produced by hyperthermia and a CCL3 derivative, Ma Liqiu;Kambe Ryosuke;Tsuchiya Tomoko;Kanegasaki Shiro;Takahashi Akihisa, 11 Nov. 2019, Cancers (Basel), 11, 11, 1770, 1770, Scientific journal

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• X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity., Puspitasari Anggraeini;Yamazaki Hiroyuki;Kawamura Hidemasa;Nakano Takashi;Takahashi Akihisa;Shirao Tomoaki;Held Kathryn D, 08 Nov. 2019, Neuroscience Research, 160, 11, 24, Scientific journal

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• 【粒子ビームサイエンスの進歩と展望-HIMACの成果を中心に】(8章)【放射線生物】放射線生物におけるHIMACの役割　炭素線治療における生物学的効果比, 高橋 昭久;吉田 由香里;安藤 興一, Oct. 2019, 68, 10, 701, Scientific journal
• 【粒子ビームサイエンスの進歩と展望-HIMACの成果を中心に】(8章)【放射線生物】放射線生物におけるHIMACの役割　炭素線治療における分割照射効果, 吉田 由香里;高橋 昭久;安藤 興一, Oct. 2019, 68, 10, 723, Scientific journal
• Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Ikeda Hiroko;Muratani Masafumi;Hidema Jun;Hada Megumi;Fujiwara Keigi;Souda Hikaru;Yoshida Yukari;Takahashi Akihisa, 26 Sep. 2019, International Journal of Molecular Sciences, 20, 19, 4791, 4791, Scientific journal

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• Melatonin is a potential drug for the prevention of bone loss during space flight., Ikegame Mika;Hattori Atsuhiko;Tabata Makoto J;Kitamura Kei-Ichiro;Tabuchi Yoshiaki;Furusawa Yukihiro;Maruyama Yusuke;Yamamoto Tatsuki;Sekiguchi Toshio;Matsuoka Risa;Hanmoto Taizo;Ikari Takahiro;Endo Masato;Omori Katsunori;Nakano Masaki;Yashima Sayaka;Ejiri Sadakazu;Taya Toshiki;Nakashima Hiroshi;Shimizu Nobuaki;Nakamura Masahisa;Kondo Takashi;Hayakawa Kazuichi;Takasaki Ichiro;Kaminishi Atsushi;Akatsuka Ryosuke;Sasayama Yuichi;Nishiuchi Takumi;Nara Masayuki;Iseki Hachiro;Chowdhury Vishwajit S;Wada Shigehito;Ijiri Kenichi;Takeuchi Toshio;Suzuki Tohru;Ando Hironori;Matsuda Kouhei;Somei Masanori;Mishima Hiroyuki;Mikuni-Takagaki Yuko;Funahashi Hisayuki;Takahashi Akihisa;Watanabe Yoshinari;Maeda Masahiro;Uchida Hideaki;Hayashi Akio;Kambegawa Akira;Seki Azusa;Yano Sachiko;Shimazu Toru;Suzuki Hiromi;Hirayama Jun;Suzuki Nobuo, 19 Jul. 2019, Journal of pineal research, 67, 3

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• Effects of p53 Status of Tumor Cells and Combined Treatment With Mild Hyperthermia, Wortmannin or Caffeine on Recovery From Radiation-Induced Damage., Masunaga Shin-Ichiro;Tano Keizo;Sanada Yu;Suzuki Minoru;Takahashi Akihisa;Ohnishi Ken;Ono Koji, 29 Jun. 2019, World journal of oncology, 10, 3

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• 宇宙を模擬した放射線と微小重力の複合曝露による染色体異常の増加, ;;, Feb. 2019, 51, 2, 76
• Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation., Hada Megumi;Ikeda Hiroko;Rhone Jordan R;Beitman Andrew J;Plante Ianik;Souda Hikaru;Yoshida Yukari;Held Kathryn D;Fujiwara Keigi;Saganti Premkumar B;Takahashi Akihisa, 22 Dec. 2018, International journal of molecular sciences, 20, 1

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• Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice., Takahashi Akihisa;Wakihata Shoto;Ma Liqiu;Adachi Takuya;Hirose Hiroki;Yoshida Yukari;Ohira Yoshinobu, 09 Dec. 2018, International journal of molecular sciences, 19, 12

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• 宇宙放射線と無重力の複合影響, ;;;, Oct. 2018, 50, 12, 640
• Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks., Takahashi Akihisa;Ikeda Hiroko;Yoshida Yukari, 21 Sep. 2018, International journal of particle therapy, 5, 1

  DOI
• Heat induces histone γH2AX gormation under hypoxia, Yoshida Y; Tominaga S; Ma L; Takahashi A, Sep. 2018, Thermal Medicine, 34, 3, 45, 51, Scientific journal
• 【宇宙の極限環境から生命体の可塑性をさぐる】宇宙空間滞在の環境リスク　宇宙放射線と重力変化環境の複合影響, ;;, Apr. 2018, 69, 2, 152
• X-ray irradiation induces disruption of the blood-brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain., Yoshida Yukari;Sejimo Yukihiko;Kurachi Masashi;Ishizaki Yasuki;Nakano Takashi;Takahashi Akihisa, 12 Mar. 2018, Neurochemistry international, 119

  DOI
• Performance evaluation of new devices to synchronize heavy-ion or X-ray irradiation and simulated microgravity for space radiation research ~ Improvement of a control stage ~., Takahashi A; Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T, 2018, The 31st International Symposium on Space Technology and Science (ISTS), proceeding (Theses ID: 2017-p-09), International conference proceedings
• Heavy-ion irradiation overcomes Lin28B-induced X-ray resistance in melanoma cells, Takahashi, Akihisa;Yoshida, Yukari;Ohno, Tatsuya;Nakano, Takashi, 2018, CANCER SCIENCE, 109, 750, 750
• Establishment and characterization of a novel highly metastatic colon carcinoma clone, Colon-26MGS, Ma, Liqiu;Takahashi, Akihisa;Imai, Takashi;Shimokawa, Takashi, 2018, CANCER SCIENCE, 109, 874, 874
• In vivo and in vitro immunochemical assay for CNS synaptic dysfunction by X-irradiation, Shirao, Tomoaki;Puspitasari, Anggraeini;Koganezawa, Noriko;Kawamura, Hidemasa;Takahashi, Akihisa;Sekino, Yuko;Nakano, Takashi;Held, Kathryn D., 2018, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 93, 136, 136

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• Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells, Seong-Joon Park; Kyu Heo; Chulwon Choi; Kwangmo Yang; Akiko Adachi; Hiroko Okada; Yukari Yoshida; Tatsuya Ohno; Takashi Nakano; Akihisa Takahashi, Nov. 2017, Journal of Radiation Research, 58, 6, 765, 771, Scientific journal

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• BRCA2 protects mammalian cells from heat shock., Nakagawa Yosuke;Kajihara Atsuhisa;Takahashi Akihisa;Murata Akiho S;Matsubayashi Masaya;Ito Soichiro S;Ota Ichiro;Nakagawa Takahiko;Hasegawa Masatoshi;Kirita Tadaaki;Ohnishi Takeo;Mori Eiichiro, 10 Sep. 2017, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 34, 6

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• Takeo Ohnishi, PhD, 1944-2017., Takahashi Akihisa;Mori Eiichiro;Ohnishi Ken;Matsumoto Hideki, 02 Aug. 2017, Radiation research, 188, 4

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• Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells, Akihisa Takahashi; Eiichiro Mori; Yosuke Nakagawa; Atsuhisa Kajihara; Tadaaki Kirita; Douglas L. Pittman; Masatoshi Hasegawa; Takeo Ohnishi, May 2017, International Journal of Hyperthermia, 33, 3, 336, 342, Scientific journal

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• Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system., Ikeda Hiroko;Souda Hikaru;Puspitasari Anggraeini;Held Kathryn D;Hidema Jun;Nikawa Takeshi;Yoshida Yukari;Kanai Tatsuaki;Takahashi Akihisa, 23 Jan. 2017, Life sciences in space research, 12

  DOI
• Future Scenario of the Space Radiation Research Using Space Environment, TAKAHASHI Akihisa;HIDEMA Jun;YASUDA Hiroshi, 2017, International journal of microgravity science and application, 34, 2
• A new system for three-dimensional clinostat synchronized X-irradiation with a high-speed shutter for space radiation research, Ikeda H; Souda H; Puspitasari A; Held KD; Hidema J; Nikawa T; Yoshida Y; Kanai T; Takahashi A, Dec. 2016, Biological Science in Space, 30, 0, 8, 16, Scientific journal

  DOI
• Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells., Takahashi Akihisa;Mori Eiichiro;Nakagawa Yosuke;Kajihara Atsuhisa;Kirita Tadaaki;Pittman Douglas L;Hasegawa Masatoshi;Ohnishi Takeo, 13 Nov. 2016, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 33, 3

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• Effects of Charged Particles on Human Tumor Cells., Held Kathryn D;Kawamura Hidemasa;Kaminuma Takuya;Paz Athena Evalour S;Yoshida Yukari;Liu Qi;Willers Henning;Takahashi Akihisa, 12 Feb. 2016, Frontiers in oncology, 6

  DOI
• A New System for Three-dimensional Clinostat Synchronized X-irradiation with a High-speed Shutter for Space Radiation Research, Ikeda Hiroko;Souda Hikaru;Puspitasari Anggraeini;Held Kathryn D.;Hidema Jun;Nikawa Takeshi;Yoshida Yukari;Kanai Tatsuaki;Takahashi Akihisa, 2016, Biological Sciences in Space, 30, 0, 8, 16
• Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775., Ma Hongyu;Takahashi Akihisa;Sejimo Yukihiko;Adachi Akiko;Kubo Nobuteru;Isono Mayu;Yoshida Yukari;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 08 Dec. 2015, Radiation research, 184, 6

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• Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells., Ma Hongyu;Takahashi Akihisa;Yoshida Yukari;Adachi Akiko;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 09 Nov. 2015, Radiation oncology (London, England), 10

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• Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells., Isono Mayu;Yoshida Yukari;Takahashi Akihisa;Oike Takahiro;Shibata Atsushi;Kubota Yoshiki;Kanai Tatsuaki;Ohno Tatsuya;Nakano Takashi, 11 Jun. 2015, Journal of radiation research, 56, 5

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• Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460., Kubo Nobuteru;Noda Shin-ei;Takahashi Akihisa;Yoshida Yukari;Oike Takahiro;Murata Kazutoshi;Musha Atsushi;Suzuki Yoshiyuki;Ohno Tatsuya;Takahashi Takeo;Nakano Takashi, 18 Jan. 2015, Journal of radiation research, 56, 2

  DOI
• Targeting of Carbon Ion-Induced G(2) Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775, Ma, Hongyu;Takahashi, Akihisa;Sejimo, Yukihiko;Adachi, Akiko;Kubo, Nobuteru;Isono, Mayu;Yoshida, Yukari;Kanai, Tatsuaki;Ohno, Tatsuya;Nakano, Takashi, 2015, RADIATION RESEARCH, 184, 6, 660, 669

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• Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells, Ma, Hongyu;Takahashi, Akihisa;Yoshida, Yukari;Adachi, Akiko;Kanai, Tatsuaki;Ohno, Tatsuya;Nakano, Takashi, 2015, RADIATION ONCOLOGY, 10

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• Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460, Kubo, Nobuteru;Noda, Shin-ei;Takahashi, Akihisa;Yoshida, Yukari;Oike, Takahiro;Murata, Kazutoshi;Musha, Atsushi;Suzuki, Yoshiyuki;Ohno, Tatsuya;Takahashi, Takeo;Nakano, Takashi, 2015, JOURNAL OF RADIATION RESEARCH, 56, 2, 229, 238

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• 3　Particle Beam Therapy for Cancer:A Radiobiological Perspective, TAKAHASHI Akihisa;YOSHIDA Yukari, 2015, RADIOISOTOPES, 64, 6, 377, 381
• Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation., Takahashi Akihisa;Kubo Makoto;Ma Hongyu;Nakagawa Akiko;Yoshida Yukari;Isono Mayu;Kanai Tatsuaki;Ohno Tatsuya;Furusawa Yoshiya;Funayama Tomoo;Kobayashi Yasuhiko;Nakano Takashi, 12 Aug. 2014, Radiation research, 182, 3

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• Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells., Murata Kazutoshi;Noda Shin-ei;Oike Takahiro;Takahashi Akihisa;Yoshida Yukari;Suzuki Yoshiyuki;Ohno Tatsuya;Funayama Tomoo;Kobayashi Yasuhiko;Takahashi Takeo;Nakano Takashi, 21 Mar. 2014, Journal of radiation research, 55, 4

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• The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells., Nakagawa Yosuke;Kajihara Atsuhisa;Takahashi Akihisa;Kondo Natsuko;Mori Eiichiro;Kirita Tadaaki;Ohnishi Takeo, 11 Mar. 2014, Oncology reports, 31, 5

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• Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells., Takahashi A; Ma H; Nakagawa A; Yoshida Y; Kanai T; Ohno T; Kuwahara Y; Fukumoto M; Nakano T, 2014, Int J Med Phys Clin Engin Radiat Oncol., 3, 133, 142
• Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation, Takahashi, Akihisa;Kubo, Makoto;Ma, Hongyu;Nakagawa, Akiko;Yoshida, Yukari;Isono, Mayu;Kanai, Tatsuaki;Ohno, Tatsuya;Furusawa, Yoshiya;Funayama, Tomoo;Kobayashi, Yasuhiko;Nakano, Takashi, 2014, RADIATION RESEARCH, 182, 3, 338, 344

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• Degradation of initiator tRNA(Met) by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells, Watanabe, Kazunori;Miyagawa, Ryu;Tomikawa, Chie;Mizuno, Rie;Takahashi, Akihisa;Hori, Hiroyuki;Ijiri, Kenichi, 2013, NUCLEIC ACIDS RESEARCH, 41, 8, 4671, 4685

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• Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation, Yosuke Nakagawa; Akihisa Takahashi; Atsuhisa Kajihara; Nobuhiro Yamakawa; Yuichiro Imai; Ichiro Ota; Noritomo Okamoto; Eiichiro Mori; Taichi Noda; Yoshiya Furusawa; Tadaaki Kirita; Takeo Ohnishi, Jul. 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423, 4, 654, 660, Scientific journal

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• Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells, T. Shimura; N. Noma; T. Oikawa; Y. Ochiai; S. Kakuda; Y. Kuwahara; Y. Takai; A. Takahashi; M. Fukumoto, Jun. 2012, ONCOGENESIS, 1, e12, Scientific journal

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• The combination of olaparib and camptothecin for effective radiosensitization, Katsutoshi Miura; Koh-ichi Sakata; Masanori Someya; Yoshihisa Matsumoto; Hideki Matsumoto; Akihisa Takahashi; Masato Hareyama, Apr. 2012, RADIATION ONCOLOGY, 7, 62, Scientific journal

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• Expression of p53-regulated proteins in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight., Takahashi Akihisa;Suzuki Hiromi;Omori Katsunori;Seki Masaya;Hashizume Toko;Shimazu Toru;Ishioka Noriaki;Ohnishi Takeo, 25 Feb. 2012, Journal of radiation research, 53, 2

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• Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells, F. Yatagai; M. Honma; A. Ukai; K. Omori; H. Suzuki; T. Shimazu; A. Takahashi; T. Ohnishi; N. Dohmae; N. Ishioka, Feb. 2012, ADVANCES IN SPACE RESEARCH, 49, 3, 479, 486, Scientific journal

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• DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines, Furusawa, Yukihiro;Fujiwara, Yoshisada;Campbell, Paul;Zhao, Qing-Li;Ogawa, Ryohei;Hassan, Mariame Ali;Tabuchi, Yoshiaki;Takasaki, Ichiro;Takahashi, Akihisa;Kondo, Takashi, 2012, PLOS ONE, 7, 1

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• Therapeutic strategies for head and neck cancer based on p53 status (Review), Ota, Ichiro;Okamoto, Noritomo;Yane, Katsunari;Takahashi, Akihisa;Masui, Takashi;Hosoi, Hiroshi;Ohnishi, Takeo, 2012, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 3, 4, 585, 591

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• Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation, Nakagawa, Yosuke;Takahashi, Akihisa;Kajihara, Atsuhisa;Yamakawa, Nobuhiro;Imai, Yuichiro;Ota, Ichiro;Okamoto, Noritomo;Mori, Eiichiro;Noda, Taichi;Furusawa, Yoshiya;Kirita, Tadaaki;Ohnishi, Takeo, 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 423, 4, 654, 660

  DOI
• Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight, Takahashi, Akihisa;Suzuki, Hiromi;Omori, Katsunori;Seki, Masaya;Hashizume, Toko;Shimazu, Toru;Ishioka, Noriaki;Ohnishi, Takeo, 2012, JOURNAL OF RADIATION RESEARCH, 53, 2, 168, 175

  DOI
• The combination of olaparib and camptothecin for effective radiosensitization, Miura, Katsutoshi;Sakata, Koh-ichi;Someya, Masanori;Matsumoto, Yoshihisa;Matsumoto, Hideki;Takahashi, Akihisa;Hareyama, Masato, 2012, RADIATION ONCOLOGY, 7

  DOI
• Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight, TAKAHASHI Akihisa;SUZUKI Hiromi;OMORI Katsunori;SEKI Masaya;HASHIZUME Toko;SHIMAZU Toru;ISHIOKA Noriaki;OHNISHI Takeo, 2012, Journal of Radiation Research, 53, 2, 168, 175
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G_2/M Phase-dependent, SU Xiaoming;TAKAHASHI Akihisa;KONDO Natsuko;NAKAGAWA Yosuke;IWASAKI Toshiyasu;GUO Guozhen;OHNISHI Takeo, Sep. 2011, 52, 5, 609, 615
• FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Minoru Suzuki; Yuko Kinashi; Shinichiro Masunaga; Koji Ono; Masatoshi Hasegawa; Takeo Ohnishi, May 2011, PLOS ONE, 6, 5, e19659, Scientific journal

  DOI
• Toward Future Space Experiments for Life Sciences, HOSON Takayuki;TAKAHASHI Akihisa;NIKAWA Takeshi;FUKUI Keiji;OGAWA Shiho;HIGASHITANI Atsushi, Apr. 2011, Biological sciences in space, 25, 1, 21, 24
• Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation, Fumio Yatagai; Masamitsu Honma; Akihisa Takahashi; Katsunori Omori; Hiromi Suzuki; Toru Shimazu; Masaya Seki; Toko Hashizume; Akiko Ukai; Kaoru Sugasawa; Tomoko Abe; Naoshi Dohmae; Shuichi Enomoto; Takeo Ohnishi; Alasdair Gordon; Noriaki Ishioka, Mar. 2011, RADIATION AND ENVIRONMENTAL BIOPHYSICS, 50, 1, 125, 134, Scientific journal

  DOI
• Expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines after spaceflight in a frozen state, A. Takahashi; H. Suzuki; K. Omori; M. Seki; T. Hashizume; T. Shimazu; N. Ishioka; T. Ohnishi, Mar. 2011, ADVANCES IN SPACE RESEARCH, 47, 6, 1062, 1070, Scientific journal

  DOI
• Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage, Taichi Noda; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Noritomo Okamoto; Yosuke Nakagawa; Ken Ohnishi; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Hideo Asada; Takeo Ohnishi, Jan. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 1, 206, 210, Scientific journal

  DOI
• siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells, Noritomo Okamoto; Akihisa Takahashi; Ichiro Ota; Ken Ohnishi; Eiichiro Mori; Natsuko Kondo; Taichi Noda; Yosuke Nakagawa; Hirokazu Uemura; Katunari Yane; Hiroshi Hosoi; Takeo Ohnishi, 2011, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 27, 3, 297, 304, Scientific journal

  DOI
• Ultrasound-induced DNA damage and signal transductions indicated by gammaH2AX, Yukihiro Furusawa; Yoshisada Fujiwara; Qing-Li Zhao; Mariame Ali Hassan; Ryohei Ogawa; Yoshiaki Tabuchi; Ichiro Takasaki; Akihisa Takahashi; Takeo Ohnishi; Takashi Kondo, 2011, 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010), 1359, 322, +, International conference proceedings

  DOI
• FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ, Kondo, Natsuko;Takahashi, Akihisa;Mori, Eiichiro;Noda, Taichi;Zdzienicka, Malgorzata Z.;Thompson, Larry H.;Helleday, Thomas;Suzuki, Minoru;Kinashi, Yuko;Masunaga, Shinichiro;Ono, Koji;Hasegawa, Masatoshi;Ohnishi, Takeo, 2011, PLOS ONE, 6, 5

  DOI
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G2/M Phase-dependent, SU Xiaoming;TAKAHASHI Akihisa;KONDO Natsuko;NAKAGAWA Yosuke;IWASAKI Toshiyasu;GUO Guozhen;OHNISHI Takeo, 2011, Journal of Radiation Research, 52, 5, 609, 615
• p53-DEPENDENT ADAPTIVE RESPONSES IN HUMAN CELLS EXPOSED TO SPACE RADIATIONS, Akihisa Takahashi; Xiaoming Su; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Toshiyasu Iwasaki; Takeo Ohnishi, Nov. 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 78, 4, 1171, 1176, Scientific journal

  DOI
• Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status, Yoko Nagata; Akihisa Takahashi; Ken Ohnishi; Ichiro Ota; Takeo Ohnishi; Takashi Tojo; Shigeki Taniguchi, Oct. 2010, INTERNATIONAL JOURNAL OF ONCOLOGY, 37, 4, 1001, 1010, Scientific journal

  DOI
• DNA ligase IV is a potential molecular target in ACNU sensitivity, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Xiaoming Su; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Koji Ono; Takeo Ohnishi, Aug. 2010, CANCER SCIENCE, 101, 8, 1881, 1885, Scientific journal

  DOI
• Gimeracil sensitizes cells to radiation via inhibition of homologous recombination, Masaru Takagi; Koh-ichi Sakata; Masanori Someya; Hiroshi Tauchi; Kenta Iijima; Yoshihisa Matsumoto; Toshihiko Torigoe; Akari Takahashi; Masato Hareyama; Masakazu Fukushima, Aug. 2010, RADIOTHERAPY AND ONCOLOGY, 96, 2, 259, 266, Scientific journal

  DOI
• The expression of p53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight, Akihisa Takahashi; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Takeo Ohnishi, Aug. 2010, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 86, 8, 669, 681, Scientific journal

  DOI
• Recent Advances in the Biology of Heavy-Ion Cancer Therapy, Nobuyuki Hamada; Tatsuhiko Imaoka; Shin-ichiro Masunaga; Toshiyuki Ogata; Ryuichi Okayasu; Akihisa Takahashi; Takamitsu A. Kato; Yasuhiko Kobayashi; Takeo Ohnishi; Koji Ono; Yoshiya Shimada; Teruki Teshima, Jul. 2010, JOURNAL OF RADIATION RESEARCH, 51, 4, 365, 383, Scientific journal

  DOI
• ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating, Akihisa Takahashi; Eiichiro Mori; Xiaoming Su; Yosuke Nakagawa; Noritomo Okamoto; Hirokazu Uemura; Natsuko Kondo; Taichi Noda; Atsushi Toki; Yosuke Ejima; David J. Chen; Ken Ohnishi; Takeo Ohnishi, Jul. 2010, JOURNAL OF RADIATION RESEARCH, 51, 4, 417, 422, Scientific journal

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• BIPHASIC EFFECTS OF NITRIC OXIDE RADICALS ON RADIATION-INDUCED LETHALITY AND CHROMOSOME ABERRATIONS IN HUMAN LUNG CANCER CELLS CARRYING DIFFERENT p53 GENE STATUS, Xiaoming Su; Akhisa Takahashi; Guozhen Guo; Eiichiro Mori; Noritomo Okamoto; Ken Ohnishi; Toshiyasu Iwasaki; Takeo Ohnishi, Jun. 2010, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 77, 2, 559, 565, Scientific journal

  DOI
• The Foci of DNA Double Strand Break-recognition Proteins Localize with gamma H2AX after Heat Treatment, Akihisa Takahashi; Eiichiro Mori; Takeo Ohnishi, Jan. 2010, JOURNAL OF RADIATION RESEARCH, 51, 1, 91, 95, Scientific journal

  DOI
• Usefulness of Hexamethylenetetramine as an Adjuvant to Radiation and Cisplatin in the Treatment of Solid Tumors: its Independency of p53 Status, Shin-ichiro Masunaga; Keizo Tano; Jun Nakamura; Masami Watanabe; Genro Kashino; Akihisa Takahashi; Hiroki Tanaka; Minoru Suzuki; Ken Ohnishi; Yuko Kinashi; Yong Liu; Takeo Ohnishi; Koji Ono, Jan. 2010, JOURNAL OF RADIATION RESEARCH, 51, 1, 27, 35, Scientific journal

  DOI
• DNA damage induced by alkylating agents and repair pathways, Natsuko Kondo; Akihisa Takahashi; Koji Ono; Takeo Ohnishi, 2010, Journal of Nucleic Acids, 2010, 543531

  DOI
• Detection of space radiation-induced double strand breaks as a track in cell nucleus, Takeo Ohnishi; Akihisa Takahashi; Aiko Nagamatsu; Katsunori Omori; Hiromi Suzuki; Toru Shimazu; Noriaki Ishioka, Dec. 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 390, 3, 485, 488, Scientific journal

  DOI
• DNA double-strand breaks: Their production, recognition, and repair in eukaryotes, Takeo Ohnishi; Eiichiro Mori; Akihisa Takahashi, Oct. 2009, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 669, 1-2, 8, 12

  DOI
• DNA ligase IV as a new molecular target for temozolomide, Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Takeo Ohnishi, Oct. 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 387, 4, 656, 660, Scientific journal

  DOI
• A low dose: pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning, A. Takahashi; T. Ohnishi, Apr. 2009, ADVANCES IN SPACE RESEARCH, 43, 8, 1185, 1192, Scientific journal

  DOI
• High LET Heavy Ion Radiation Induces p53-Independent Apoptosis, Eiichiro Mori; Akihisa Takahashi; Nobuhiro Yamakawa; Tadaaki Kirita; Takeo Ohnishi, Jan. 2009, JOURNAL OF RADIATION RESEARCH, 50, 1, 37, 42

  DOI
• Alkylating agents-induced DNA damage- Repair Mechanisms and Application for Cancer Therapy, N. Kondo; A. Takahashi; T. Ohnishi, 2009, Radiat. Biol. Res. Commun, 44, 140, 153
• Computational image processing and analysis of heat-induced γH2AX foci., Somakos GI; Takahashi A; Mori E; Ohnishi T, 2009, Thermal Med., 25, 25, 34

  DOI
• A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status., Takahashi A; Ohnishi T, 2009, Thermal Med., 25, 13, 23

  DOI
• Restraint plus water-immersion stress (RWIS)-induced stomach ulcers in mice are depressed by a conditioning heat treatment., Yamagata R; Takahashi A; Su X; Morimoto T; Ohnishi T, 2009, Thermal Med., 25, 81, 87

  DOI
• Chemotherapy combined with hyperthermia improves the prognosis for non-small-cell lung cancer., Toki A; Takahashi A; Tachibana S, 2009, Thermal Med., 25, 4, 115, 122

  DOI
• DNA Damage Recognition Proteins Localize along Heavy Ion Induced Tracks in the Cell Nucleus, Aklhlsa Takahashi; Nobuhiro Yamakawa; Tadaaki Kirita; Katsunori Omori; Noriaki Ishioka; Yoshiya Furusawa; Eiichiro Mori; Ken Ohnishi; Takeo Ohnishi, Nov. 2008, JOURNAL OF RADIATION RESEARCH, 49, 6, 645, 652, Scientific journal

  DOI
• Heat induces gammaH2AX foci formation in mammalian cells., Takahashi A; Mori E; Somakos GI; Ohnishi K; Ohnishi T, Oct. 2008, Mutation research, 656, 1-2, 88, 92

  DOI
• High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation, Nobuhiro Yamakawa; Akihisa Takahashi; Eiichiro Mori; Yuichiro Imai; Yoshiya Furusawa; Ken Ohnishi; Tadaaki Kirita; Takeo Ohnishi, Jul. 2008, CANCER SCIENCE, 99, 7, 1455, 1460, Scientific journal

  DOI
• Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP, Ken Ohnishi; Yoko Nagata; Akihisa Takahashi; Shigeki Taniguchi; Takeo Ohnishi, Jul. 2008, ONCOLOGY REPORTS, 20, 1, 57, 61, Scientific journal
• Hdm2 and nitric oxide radicals contribute to the p53-dependent radioadaptive response, Akihisa Takahashi; Hideki Matsumoto; Takeo Ohnishi, Jun. 2008, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 71, 2, 550, 558, Scientific journal

  DOI
• Time course and spacial distribution of UV effects on human skin in organ culture, Eiichiro Mori; Akihisa Takahashi; Kou Kitagawa; Saki Kakei; Daiki Tsujinaka; Megumi Unno; Shoko Nishikawa; Ken Ohnishi; Mitsuo Hatoko; Norio Murata; Masakatsu Watanabe; Yoshiya Furusawa; Takeo Ohnishi, May 2008, JOURNAL OF RADIATION RESEARCH, 49, 3, 269, 277, Scientific journal

  DOI
• Development of thermotolerance requires interaction between polymerase-beta and heat shock proteins, Akihisa Takahashi; Nobuhiro Yamakawa; Eiichiro Mori; Ken Ohnishi; Shin-ichi Yokota; Noriyuki Sugo; Yasuaki Aratani; Hideki Koyama; Takeo Ohnishi, May 2008, CANCER SCIENCE, 99, 5, 973, 978, Scientific journal

  DOI
• Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes, Atsuhisa Kajihara; Akihisa Takahashi; Ken Ohnishi; Yuichiro Imai; Nobuhiro Yamakawa; Jun-ichi Yasumoto; Takeo Ohnishi; Tadaaki Kirita, 2008, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 24, 8, 605, 612, Scientific journal

  DOI
• Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population, Shin-ichiro Masunaga; Akihisa Takahashi; Ken Ohnishi; Kenji Nagata; Minoru Suzuki; Genro Kashino; Yuko Kinashi; Takeo Ohnishi; Koji Ono, Dec. 2007, ONCOLOGY REPORTS, 18, 6, 1589, 1596, Scientific journal
• Nitric oxide radicals choreograph a radioadaptive response, Hideki Matsumoto; Akihisa Takahashi; Takeo Ohnishi, Sep. 2007, CANCER RESEARCH, 67, 18, 8574, 8579, Scientific journal

  DOI
• Vanguards of Paradigm Shift in Radiation Biology : Radiation-Induced Adaptive and Bystander Responses, MATSUMOTO Hideki;HAMADA Nobuyuki;TAKAHASHI Akihisa;KOBAYASHI Yasuhiko;OHNISHI Takeo, Mar. 2007, Journal of Radiation Research, 48, 2, 97, 106
• Heat-induced phosphorylation of NBS1 in human skin fibroblast cells, Ken Ohnishi; Zorica Scuric; David Yau; Robert H. Schiestl; Noritomo Okamoto; Akihisa Takahashi; Takeo Ohnishi, Dec. 2006, JOURNAL OF CELLULAR BIOCHEMISTRY, 99, 6, 1642, 1650, Scientific journal

  DOI
• siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status, Ken Ohnishi; Zorica Scuric; Robert H. Schiestl; Noritomo Okamoto; Akihisa Takahashi; Takeo Ohnishi, Sep. 2006, RADIATION RESEARCH, 166, 3, 454, 462, Scientific journal

  DOI
• Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells, Ken Ohnishi; Shinichi Yokota; Akihisa Takahashi; Takeo Ohnishi, Aug. 2006, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 82, 8, 569, 575, Scientific journal

  DOI
• LY294002, an inhibitor of PI-3K, enhances heat sensitivity independently of p53 status in human lung cancer cells, Ken Ohnishi; Jun-Ichi Yasumoto; Akihisa Takahashi; Takeo Ohnishi, Jul. 2006, INTERNATIONAL JOURNAL OF ONCOLOGY, 29, 1, 249, 253, Scientific journal
• UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis, A Takahashi; N Shibata; S Nishikawa; K Ohnishi; N Ishioka; T Ohnishi, 2006, PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 5, 5, 467, 471, Scientific journal

  DOI
• Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status, A Takahashi; H Matsumoto; Y Furusawa; K Ohnishi; N Ishioka; T Ohnishi, Aug. 2005, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 81, 8, 581, 586, Scientific journal

  DOI
• Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells, SI Masunaga; H Nagasawa; Y Uto; H Hori; K Ohnishi; A Takahashi; T Ohnishi; M Suzuki; K Nagata; Y Kinashi; K Ono, Aug. 2005, ONCOLOGY REPORTS, 14, 2, 393, 400, Scientific journal
• Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis, Y Imai; K Ohnishi; J Yasumoto; A Kajiwara; N Yamakawa; A Takahashi; T Ohnishi; T Kirita, Jul. 2005, ORAL ONCOLOGY, 41, 6, 631, 636, Scientific journal

  DOI
• Reactivation in Paramecium tetraurelia under conditions of various degrees of ozone layer depletion, A Takahashi; T Kumatani; S Usui; R Tsujimura; T Seki; K Morimoto; T Ohnishi, Jul. 2005, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 81, 4, 1010, 1014, Scientific journal

  DOI
• Evidence for the involvement of double-strand breaks in heat-induced cell killing, A Takahashi; H Matsumoto; K Nagayama; M Kitano; S Hirose; H Tanaka; E Mori; N Yamakawa; J Yasumoto; K Yuki; K Ohnishi; T Ohnishi, Dec. 2004, CANCER RESEARCH, 64, 24, 8839, 8845, Scientific journal

  DOI
• Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene, K Yuki; A Takahashi; Ota, I; K Ohnishi; J Yasumoto; K Yane; H Kanata; N Okamoto; H Hosoi; T Ohnishi, Nov. 2004, APOPTOSIS, 9, 6, 853, 859, Scientific journal

  DOI
• High-let radiation enhanced apoptosis but not necrosis regardless of P53 status, A Takahashi; H Matsumoto; K Yuki; JI Yasumoto; A Kajiwara; M Aoki; Y Furusawa; K Ohnishi; T Ohnishi, Oct. 2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 2, 591, 597, Scientific journal

  DOI
• Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations, SI Masunaga; A Takahashi; K Ohnishi; T Ohnishi; K Nagata; M Suzuki; Y Kinashi; K Ono, Oct. 2004, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 60, 2, 570, 577, Scientific journal

  DOI
• C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells, K Ohnishi; H Inaba; J Yasumoto; K Yuki; A Takahashi; T Ohnishi, Sep. 2004, APOPTOSIS, 9, 5, 591, 597, Scientific journal

  DOI
• Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status, K Ohnishi; A Takahashi; S Yokota; T Ohnishi, Aug. 2004, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 80, 8, 607, 614, Scientific journal

  DOI
• Comparative study of otolith organs between two species of upside-down swimming catfish Synodontis nigriventris showing converse swimming postures, K Ohnishi; Y Ogawa; A Takahashi; M Yamashita; T Ohnishi, Jul. 2004, ACTA ZOOLOGICA, 85, 3, 201, 209, Scientific journal

  DOI
• Glycerol enhances CDDP-induced growth inhibition of thyroid anaplastic carcinoma tumor carrying mutated p53 gene, K Yuki; A Takahashi; Ota, I; K Ohnishi; JI Yasumoto; H Kanata; K Yane; H Hosoi; T Ohnishi, Apr. 2004, ONCOLOGY REPORTS, 11, 4, 821, 824, Scientific journal
• Apoptosis-related gene expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53, J Yasumoto; T Kirita; A Takahashi; K Ohnishi; Y Imai; K Yuki; T Ohnishi, Feb. 2004, CANCER LETTERS, 204, 1, 41, 51, Scientific journal

  DOI
• Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation, A. Takahashi; K. Ohnishi; T. Ohnishi, 2004, International Journal of Low Radiation, 1, 2, 199, 207, Scientific journal

  DOI
• Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53, T Tamamoto; H Yoshimura; A Takahashi; Asakawa, I; Ota, I; H Nakagawa; K Ohnishi; H Ohishi; T Ohnishi, Nov. 2003, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 19, 6, 590, 597, Scientific journal

  DOI
• The effect of clinorotation on vestibular compensation in upside-down swimming catfish., Ohnishi K; Okamoto N; Yamanaka T; Takahashi A; Hosoi H; Ohnishi T, Oct. 2003, Biol Sci Space., 17, 3, 165, 166
• Effects of p53 Status and Wortmannin Treatment on Potentially Lethal Damage Repair, with Emphasis on the Response of Intratumor Quiescent Cells, Shin-Ichiro Masunaga; Akihisa Takahashi; Ken Ohnishi; Takeo Ohnishi; Minoru Suzuki; Kenji Nagata; Yuko Kinashi; Koji Ono, May 2003, Radiation Medicine - Medical Imaging and Radiation Oncology, 21, 3, 120, 127, Scientific journal
• Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene, J Yasumoto; Y Imai; A Takahashi; K Ohnishi; K Yuki; T Kirita; T Ohnishi, Mar. 2003, JOURNAL OF RADIATION RESEARCH, 44, 1, 41, 45, Scientific journal

  DOI
• Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status, S Masunaga; K Ono; A Takahashi; K Ohnishi; T Ohnishi; M Suzuki; K Nagata; Y Kinashi; H Nagasawa; Y Uto; H Hori, Jan. 2003, CANCER SCIENCE, 94, 1, 125, 133, Scientific journal

  DOI
• Radiation-induced apoptosis in SCID mice spleen after low dose irradiation, A Takahashi; N Kondo; H Inaba; K Uotani; Y Kiyohara; K Ohnishi; T Ohnishi, 2003, SPACE LIFE SCIENCES: BIODOSIMETRY, BIOMARKERS AND LATE STOCHASTIC EFFECTS OF SPACE RADIATION, 31, 6, 1569, 1573, Scientific journal

  DOI
• p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation, A Takahashi; Ota, I; T Tamamoto; Asakawa, I; Y Nagata; H Nakagawa; N Kondo; K Ohnishi; Y Furusawa; H Matsumoto; T Ohnishi, 2003, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 19, 2, 145, 153, Scientific journal

  DOI
• Usefulness of combined treatment with mild hyperthermia and/or tirapazamine in the treatment of solid tumors consisting of mutated p53 status cells, Masunaga S; Ono K; Takahashi A; Ohnishi K; Ohnishi T; Suzuki M; Nagata K; Kinashi Y; Nagasawa H; Uto Y; Hori H, 2003, Int J Radiat Oncol Biol Phys, 55, 485, 486
• Impact of the p53 status of the tumor cells on the effect of reactor neutron beam irradiation, with emphasis on the response of intratumor quiescent cells, S Masunaga; K Ono; A Takahashi; Y Sakurai; K Ohnishi; T Kobayashi; Y Kinashi; M Takagaki; T Ohnishi, Dec. 2002, JAPANESE JOURNAL OF CANCER RESEARCH, 93, 12, 1366, 1377, Scientific journal

  DOI
• Detection of DNA damage induced by space radiation in Mir and space shuttle, T Ohnishi; K Ohnishi; A Takahashi; Y Taniguchi; M Sato; T Nakano; S Nagaoka, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S133, S136, Scientific journal

  DOI
• Mutation frequency of plasmid DNA and Escherichia coli following long-term space flight on Mir, A Takahashi; K Ohnishi; A Yokota; T Kumagai; T Nakano; T Ohnishi, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S137, S140, Scientific journal

  DOI
• Studies about space radiation promote new fields in radiation biology, T Ohnishi; A Takahashi; K Ohnishi, Dec. 2002, JOURNAL OF RADIATION RESEARCH, 43, S7, S12, Scientific journal
• Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells, Ken Ohnishi; Ichiro Ota; Akihisa Takahashi; Kazue Yuki; Mie Emoto; Hiroshi Hosoi; Takeo Ohnishi, 04 Oct. 2002, Molecular Cancer, 1, 4, Scientific journal

  DOI
• Analysis of death pattern in cancer cells by using different kinds of LET radiation, Akihisa Takahashi; Ken Ohnishi; Mizuho Aoki; Yoshiya Furusawa; Takeo Ohnishi, Sep. 2002, Nippon Acta Radiologica, 62, 10, 531, 534, Scientific journal
• Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck, K Ohnishi; Ota, I; A Takahashi; K Yane; H Matsumoto; T Ohnishi, Aug. 2002, APOPTOSIS, 7, 4, 367, 372, Scientific journal

  DOI
• Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation, A Takahashi; Asakawa, I; K Yuki; T Matsumoto; M Kumamoto; N Kondo; K Ohnishi; A Tachibana; T Ohnishi, Aug. 2002, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 78, 8, 689, 693, Scientific journal

  DOI
• Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status, Asakawa, I; H Yoshimura; A Takahashi; K Ohnishi; H Nakagawa; Ota, I; Y Furusawa; T Tamamoto; H Ohishi; T Ohnishi, Jul. 2002, ANTICANCER RESEARCH, 22, 4, 2037, 2043, Scientific journal
• Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53, Takeo Ohnishi; Ken Ohnishi; Akihisa Takahashi, 19 Apr. 2002, BMC Biotechnology, 2, 6, Scientific journal

  DOI
• Radiobiological characteristics of solid tumours depending on the p53 status of the tumour cells, with emphasis on the response of intratumour quiescent cells, S Masunaga; K Ono; A Takahashi; T Ohnishi; Y Kinashi; M Takagaki, Mar. 2002, EUROPEAN JOURNAL OF CANCER, 38, 5, 718, 727, Scientific journal

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• High transmittance of X-rays in the utricular otolith of upside-down swimming catfish, Synodontis nigriventris., Ohnishi K; Yamamoto T; Ogawa Y; Takahashi A; Yamashita M; Ohnishi T, Mar. 2002, Biol Sci Space., 16, 1, 18, 21

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• Significance of the p53 status of the tumor cells in neutron captutre therapy, S Masunaga; K Ono; A Takahashi; Y Sakurai; T Kobayashi; Y Kinashi; T Ohnishi, 2002, RESEARCH AND DEVELOPMENT IN NEUTRON CAPTURE THERAPY, 739, 743, International conference proceedings
• p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET, A Takahashi; K Ohnishi; Ota, I; Asakawa, I; T Tamamoto; Y Furusawa; H Matsumoto; T Ohnishi, Oct. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 10, 1043, 1051, Scientific journal

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• Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation, A Takahashi; K Ohnishi; Asakawa, I; N Kondo; H Nakagawa; M Yonezawa; A Tachibana; H Matsumoto; T Ohnishi, Sep. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 9, 939, 945, Scientific journal

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• Alkylating agent (MNU)-induced mutation in space environment, T. Ohnishi; A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka, Aug. 2001, Advances in Space Research, 28, 4, 563, 568, Scientific journal

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• The effects of microgravity on induced mutation in Escherichia coli and saccharomyces cerevisiae, A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka; T. Ohnishi, Aug. 2001, Advances in Space Research, 28, 4, 555, 561, Scientific journal

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• Differentation of dictyostelium discoideum vegetative cells into spores during earth orbit in space, A. Takahashi; K. Ohnishi; S. Takahashi; M. Masukawa; K. Sekikawa; T. Amano; T. Nakano; S. Nagaoka; T. Ohnishi, Aug. 2001, Advances in Space Research, 28, 4, 549, 553, Scientific journal

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• Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells, A Takahashi, Feb. 2001, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77, 2, 215, 224, Scientific journal

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• Tumor suppressor p53 response is blunted by low-dose-rate radiation, T Ohnishi; A Takahashi; K Ohnishi; M Yonezawa, 2001, PHYSICA MEDICA, 17, 215, 216, Scientific journal
• Possible enhancement p53 gene therapy for undifferentiated thyroid carcinomas, Ota, I; K Yane; H Miyahara; M Emoto; K Ohnishii; A Takahashi; H Hosoi; T Ohnishi, 2001, BRONCHOLOGY AND BRONCHOESOPHAGOLOGY: STATE OF THE ART, 1217, 889, 891, International conference proceedings
• Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53, K Ohnishi; Ota, I; A Takahashi; T Ohnishi, Dec. 2000, BRITISH JOURNAL OF CANCER, 83, 12, 1735, 1739, Scientific journal

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• Analysis of deletion mutations of the rpsL gene in the yeast Saccharomyces cerevisiae detected after long-term flight on the Russian space station Mir, T Fukuda; K Fukuda; A Takahashi; T Ohnishi; T Nakano; M Sato; N Gunge, Oct. 2000, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 470, 2, 125, 132, Scientific journal

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• CDDP induces p53-dependent apoptosis in tongue cancer cells, H Kanata; K Yane; Ota, I; H Miyahara; T Matsunaga; A Takahashi; K Ohnishi; T Ohnishi; H Hosoi, Sep. 2000, INTERNATIONAL JOURNAL OF ONCOLOGY, 17, 3, 513, 517, Scientific journal
• rpsL mutation induction after space flight on MIR, F Yatagai; T Saito; A Takahashi; A Fujie; S Nagaoka; M Sato; T Ohnishi, Sep. 2000, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 453, 1, 1, 4, Scientific journal

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• The effects of microgravity on ligase activity in the repair of DNA double-strand breaks, A Takahashi; K Ohnishi; S Takahashi; M Masukawa; K Sekikawa; T Amano; T Nakano; S Nagaoka; T Ohnishi, Jun. 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 6, 783, 788, Scientific journal
• Brief Communication: Heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from the SCID mouse, T Ohnishi; K Komatsu; H Tauchi; Wang, X; A Takahashi; K Ohnishi; A Shiba; H Matsumoto, May 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 5, 711, 715, Scientific journal
• The dependence of p53 on the radiation enhancement of thermosensitivity at different LET, A Takahashi; K Ohnishi; XJ Wang; M Kobayashi; H Matsumoto; T Tamamoto; H Aoki; Y Furusawa; O Yukawa; T Ohnishi, May 2000, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 47, 2, 489, 494, Scientific journal

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• Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma, Ota, I; K Ohnishi; A Takahashi; K Yane; H Kanata; H Miyahara; T Ohnishi; H Hosoi, May 2000, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 47, 2, 495, 501, Scientific journal

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• WAF1 accumulation by carbon-ion beam and alpha-particle irradiation in human glioblastoma cultured cells, A Takahashi; K Ohnishi; K Tsuji; H Matsumoto; H Aoki; Wang, X; T Tamamoto; O Yukawa; Y Furusawa; Y Ejima; A Tachibana; T Ohnishi, Mar. 2000, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76, 3, 335, 341, Scientific journal
• Enzymic chemical reaction under microgravity environment in space., Ohnishi T; Takahashi A; Ohnishi K; Nakano T; Nagaoka S, 2000, J Gravit Phys., 7, 69, 70
• Accumulation of tumor suppressor p53 in rat muscle after a space flight, T Ohnishi; Wang, X; S Fukuda; A Takahashi; K Ohnishi; S Nagaoka, 2000, LIFE SCIENCES: MICROGRAVITY AND SPACE RADIATION EFFECTS, 25, 10, 2119, 2122, Scientific journal
• Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight, T Ohnishi; A Takahashi; XJ Wang; K Ohnishi; Y Ohira; S Nagaoka, Dec. 1999, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 430, 2, 271, 274, Scientific journal

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• Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells, M Fujino; K Ohnishi; M Asahi; Wang, X; A Takahashi; T Ohnishi, Oct. 1999, BRITISH JOURNAL OF DERMATOLOGY, 141, 4, 652, 657, Scientific journal

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• Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis, VV Ostapenko; XJ Wang; K Ohnishi; A Takahashi; Yamamoto, I; Y Tanaka; T Ohnishi, Sep. 1999, RADIATION RESEARCH, 152, 3, 321, 327, Scientific journal

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• Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene, T Ohnishi; H Matsumoto; Wang, X; A Takahashi; T Tamamoto; K Ohnishi, Sep. 1999, INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 75, 9, 1095, 1098, Scientific journal

  DOI
• The effect of labyrinthectomy on postural control of upside-down swimming catfish, Synodontis nigriventris, under pseudomicrogravity, K Ohnishi; T Yamamoto; A Takahashi; H Tanaka; M Koyama; T Ohnishi, Aug. 1999, PHYSIOLOGY & BEHAVIOR, 67, 1, 89, 93, Scientific journal

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• The protein kinase inhibitor, H-7, suppresses heat-induced activation of heat shock transcription factor 1, K Ohnishi; Wang, X; A Takahashi; H Matsumoto; T Ohnishi, Jul. 1999, MOLECULAR AND CELLULAR BIOCHEMISTRY, 197, 1-2, 129, 135, Scientific journal

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• Correlation between gamma-ray-induced G(2) arrest and radioresistance in two human cancer cells, T Tamamoto; K Ohnishi; A Takahashi; XJ Wang; H Yosimura; H Ohishi; H Uchida; T Ohnishi, Jul. 1999, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 44, 4, 905, 909, Scientific journal

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• Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone, T Ohnishi; K Ohnishi; XJ Wang; A Takahashi; K Okaichi, Apr. 1999, RADIATION RESEARCH, 151, 4, 498, 500, Scientific journal

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• Detection of DNA damages and repair in human culture cells with simulated space radiation, S Nagaoka; T Nakano; S Endo; T Onizuka; Y Kagawa; K Fujitaka; K Ohnishi; A Takahashi; T Ohnishi, Apr. 1999, ACTA ASTRONAUTICA, 44, 7-12, 561, 567, Scientific journal

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• Low-dose-rate radiation attenuates the response of the tumor suppressor TP53, T Ohnishi; XJ Wang; A Takahashi; K Ohnishi; Y Ejima, Mar. 1999, RADIATION RESEARCH, 151, 3, 368, 372, Scientific journal

  DOI
• Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation, XJ Wang; K Ohnishi; A Takahashi; T Ohnishi, Dec. 1998, ONCOGENE, 17, 22, 2819, 2825, Scientific journal

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• Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line, K Ohnishi; XJ Wang; A Takahashi; H Matsumoto; H Aoki; T Ohnishi, Apr. 1998, CELLULAR SIGNALLING, 10, 4, 259, 264, Scientific journal

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• Hyperthermic enhancement of tumour growth inhibition by accelerated carbon-ions in transplantable human esophageal cancer, T Ohnishi; A Takahashi; T Yano; H Matsumoto; Wang, X; K Ohnishi; T Tamamoto; K Tsuji; Y Furusawa; O Yukawa, Mar. 1998, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14, 2, 195, 202, Scientific journal
• p53-independent WAF1 induction by ACNU in human glioblastoma cells, H Aoki; K Ohnishi; XJ Wang; A Takahashi; T Ohnishi; M Nakamura; T Sakaki, Mar. 1998, MOLECULAR CARCINOGENESIS, 21, 3, 171, 176, Scientific journal

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• p53-dependent induction of WAF1 by cold shock in human glioblastoma cells, T Ohnishi; XJ Wang; K Ohnishi; A Takahashi, Mar. 1998, ONCOGENE, 16, 11, 1507, 1511, Scientific journal

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• Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines, K Ohnishi; XJ Wang; A Takahashi; T Ohnishi, Feb. 1998, EXPERIMENTAL CELL RESEARCH, 238, 2, 399, 406, Scientific journal

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• Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice, A Takahashi; T Yano; H Matsumoto; XJ Wang; K Ohnishi; T Tamamoto; K Tsuji; O Yukawa; T Ohnishi, Jan. 1998, CANCER LETTERS, 122, 1-2, 181, 186, Scientific journal

  DOI
• Accumulation of stress protein 72 (HSP72) in muscle and spleen of goldfish taken into space, T. Ohnishi; K. Tsuji; T. Ohmura; H. Matsumoto; X. Wang; A. Takahahsi; S. Nagaoka; A. Takabayashi, 1998, Advances in Space Research, 21, 8-9, 1077, 1080

  DOI
• Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation, XJ Wang; A Takahashi; K Ohnishi; H Matsumoto; K Suda; T Ohnishi, Nov. 1997, EXPERIMENTAL CELL RESEARCH, 237, 1, 186, 191, Scientific journal

  DOI
• p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells, T Ohtsubo; XJ Wang; A Takahashi; K Ohnishi; H Saito; CW Song; T Ohnishi, Sep. 1997, CANCER RESEARCH, 57, 18, 3910, 3913, Scientific journal
• Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress, H Matsumoto; A Takahashi; XJ Wang; K Ohnishi; T Ohnishi, Jul. 1997, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 38, 5, 1089, 1095, Scientific journal

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• Induction of cdk2 after gamma-ray irradiation is dependent on p53 status, H Matsumoto; XJ Wang; A Takahashi; T Ohnishi, Jun. 1997, INTERNATIONAL JOURNAL OF ONCOLOGY, 10, 6, 1257, 1260, Scientific journal
• Cell growth and morphology of Dictyostelium discoideum in space environment., Ohnishi T; Takahashi A; Okaichi K; Ohnishi K; Matsumoto H; Takahashi S; Yamanaka H; Nakano T; Nagaoka S, 1997, Biol Sci Space., 11, 1, 29, 34

  DOI
• Mutation frequency of Dictyostelium discoideum spores exposed to the space environment., Akihisa Takahashi; Ken Ohnishi; Mitsuyo Fukui; Tamotsu Nakano; Katsumi Yamaguchi; Shunji Nagaoka; Takeo Ohnishi, 1997, Biological Sciences in Space, 11, 2, 81, 86, Scientific journal

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• Heat shock transcription factor, HSF, is activated by ultraviolet irradiation, K Ohnishi; H Matsumoto; A Takahashi; XJ Wang; T Ohnishi, Dec. 1996, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 64, 6, 949, 952, Scientific journal
• p53 accumulation in the organs of low-dose X-ray-irradiated mice, XJ Wang; H Matsumoto; A Takahashi; T Nakano; K Okaichi; M Ihara; T Ohnishi, Jun. 1996, CANCER LETTERS, 104, 1, 79, 84, Scientific journal

  DOI
• p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells, T Ohnishi; XJ Wang; K Ohnishi; H Matsumoto; A Takahashi, Jun. 1996, JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 24, 14510, 14513, Scientific journal

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• Relationship between frequency of upside-down posture and space size around upside-down catfish, Synodontis nigriventris., Ohnishi K; Takahashi A; Tanaka H; Ohnishi T, 1996, Biol Sci Space., 10, 247, 251

  DOI
• DNA-damaging agents induce the 72-kD heat shock protein in SV40 transformed normal human fibroblasts, Tsutomu Muramatsu; Haruhiko Ohno; Toshihiko Shirai; Akihisa Takahashi; Takeo Ohnishi, 1996, Journal of Dermatology, 23, 9, 589, 593, Scientific journal

  DOI
• Postural control under clinorotation in upside-down catfish, Synodontis nigriventris., Ken Ohnishil; Akihisa Takahashi; Masato Koyama; Takeo Ohnishi, 1996, Biological Sciences in Space, 10, 4, 252, 258, Scientific journal

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• ACCUMULATION OF MUTANT P53 AND HSP72 BY HEAT-TREATMENT, AND THEIR ASSOCIATION IN A HUMAN GLIOBLASTOMA CELL-LINE, T OHNISHI; H MATSUMOTO; A TAKAHASHI; M SHIMURA; HJ MAJIMA, Sep. 1995, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11, 5, 663, 671, Scientific journal

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• 8-METHOXYPSORALEN PLUS UVA INDUCES THE 72 KDA HEAT-SHOCK PROTEIN IN ORGAN-CULTURED NORMAL HUMAN SKIN, T MURAMATSU; Y YAMASHINA; H TADA; N KOBAYASHI; M YAMAJI; H OHNO; T SHIRAI; A TAKAHASHI; T OHNISHI, Dec. 1993, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 58, 6, 809, 812, Scientific journal

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• LIGHT-INDUCED ANTHOCYANIN REDUCES THE EXTENT OF DAMAGE TO DNA IN UV-IRRADIATED CENTAUREA-CYANUS CELLS IN CULTURE, A TAKAHASHI; K TAKEDA; T OHNISHI, Jun. 1991, PLANT AND CELL PHYSIOLOGY, 32, 4, 541, 547, Scientific journal
• Stable blue complexes of anthocyanin-aluminium-3-p-coumaroyl- or 3-caffeoyl-quinic acid involved in the blueing of Hydrangea flower, Kosaku Takeda; Tomoko Yamashita; Akihisa Takahashi; Colin F. Timberlake, 1990, Phytochemistry, 29, 4, 1089, 1091, Scientific journal

  DOI
• Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells., Park Seong-Joon;Heo Kyu;Choi Chulwon;Yang Kwangmo;Adachi Akiko;Okada Hiroko;Yoshida Yukari;Ohno Tatsuya;Nakano Takashi;Takahashi Akihisa, Journal of radiation research, 58, 6

  DOI
• Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells, Murata, Kazutoshi;Noda, Shin-ei;Oike, Takahiro;Takahashi, Akihisa;Yoshida, Yukari;Suzuki, Yoshiyuki;Ohno, Tatsuya;Funayama, Tomoo;Kobayashi, Yasuhiko;Takahashi, Takeo;Nakano, Takashi, 2014, JOURNAL OF RADIATION RESEARCH, 55, 4, 658, 664

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• Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations, Yamanouchi, Sakuya;Rhone, Jordan;Mao, Jian-Hua;Fujiwara, Keigi;Saganti, Premkumar B.;Takahashi, Akihisa;Hada, Megumi, 2020, LIFE-BASEL, 10, 9

  DOI
• Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars, Takahashi, Akihisa;Yamanouchi, Sakuya;Takeuchi, Kazuomi;Takahashi, Shogo;Tashiro, Mutsumi;Hidema, Jun;Higashitani, Atsushi;Adachi, Takuya;Zhang, Shenke;Guirguis, Fady Nagy Lotfy;Yoshida, Yukari;Nagamatsu, Aiko;Hada, Megumi;Takeuchi, Kunihito;Takahashi, Tohru;Sekitomi, Yuji, 2020, LIFE-BASEL, 10, 11

  DOI
• X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity, Puspitasari, Anggraeini;Yamazaki, Hiroyuki;Kawamura, Hidemasa;Nakano, Takashi;Takahashi, Akihisa;Shirao, Tomoaki;Held, Kathryn D., 2020, NEUROSCIENCE RESEARCH, 160, 11, 24

  DOI
• Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b, Kim, Eun Ho;Kim, Jeong Yub;Kim, Mi-Sook;Vares, Guillaume;Ohno, Tatsuya;Takahashi, Akihisa;Uzawa, Akiko;Seo, Seung-Jun;Sai, Sei, 2020, AMERICAN JOURNAL OF CANCER RESEARCH, 10, 12, 4357, 4371
• Hibernation as a Tool for Radiation Protection in Space Exploration, Puspitasari, Anggraeini;Cerri, Matteo;Takahashi, Akihisa;Yoshida, Yukari;Hanamura, Kenji;Tinganelli, Walter, 2021, LIFE-BASEL, 11, 1

  DOI
• Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment, Zhang, Shenke;Ueno, Daishin;Ohira, Takashi;Kato, Hisashi;Izawa, Tetsuya;Yamanouchi, Sakuya;Yoshida, Yukari;Takahashi, Akihisa;Ohira, Yoshinobu, 2021, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 9

  DOI
• ⁶⁴Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity, Nachankar, Ankita;Oike, Takahiro;Hanaoka, Hirofumi;Kanai, Ayaka;Sato, Hiro;Yoshida, Yukari;Obinata, Hideru;Sakai, Makoto;Osu, Naoto;Hirota, Yuka;Takahashi, Akihisa;Shibata, Atsushi;Ohno, Tatsuya, 2021, CANCERS, 13, 24

  DOI
• Th Balance-Related Host Genetic Background Affects the Therapeutic Effects of Combining Carbon-Ion Radiation Therapy With Dendritic Cell Immunotherapy, Ma, Liqiu;Sakamoto, Yoshimitsu;Ando, Ken;Fujita, Hidetoshi;Takahashi, Akihisa;Takeshima, Tsuguhide;Otsuka, Hiromi;Ebner, Daniel K.;Kakimi, Kazuhiro;Imai, Takashi;Shimokawa, Takashi, 2022, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 112, 3, 780, 789

  DOI
• Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells, Beheshti, Afshin;McDonald, J. Tyson;Hada, Megumi;Takahashi, Akihisa;Mason, Christopher E.;Mognato, Maddalena, 2021, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22, 19

  DOI
• Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Ju, Zhenlin;Thomas, Tamlyn N.;Chiu, Yi-Jen;Yamanouchi, Sakuya;Yoshida, Yukari;Abe, Jun-ichi;Takahashi, Akihisa;Wang, Jing;Fujiwara, Keigi;Hada, Megumi, 2022, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23, 11

  DOI
• Synthetic torpor protects rats from exposure to accelerated heavy ions, Puspitasari, Anggraeini;Squarcio, Fabio;Quartieri, Martina;Totis, Cristina;Hitrec, Timna;Takahashi, Akihisa;Yoshida, Yukari;Hanamura, Kenji;Yako, Tomoko;Cerri, Matteo;Simoniello, Palma;Durante, Marco;Tinganelli, Walter, 2022, SCIENTIFIC REPORTS, 12, 1

  DOI
• Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Hirayama, Jun;Hattori, Atsuhiko;Takahashi, Akihisa;Furusawa, Yukihiro;Tabuchi, Yoshiaki;Shibata, Masahiro;Nagamatsu, Aiko;Yano, Sachiko;Maruyama, Yusuke;Matsubara, Hajime;Sekiguchi, Toshio;Suzuki, Nobuo, 2023, JOURNAL OF PINEAL RESEARCH, 74, 1

  DOI
• A new type of simulated partial gravity apparatus for rats based on a pully-spring system, Zhang, Shenke;Adachi, Takuya;Zhang, Shengli;Yoshida, Yukari;Takahashi, Akihisa, 2022, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 10

  DOI
• Partial liver irradiation in rats induces the hypertrophy of nonirradiated liver lobes through hepatocyte proliferation^&DAG;, Adachi, Takuya;Yoshida, Yukari;Shibuya, Kei;Sato, Ken;Yamazaki, Yuichi;Kakizaki, Satoru;Uraoka, Toshio;Takahashi, Akihisa, 2023, JOURNAL OF RADIATION RESEARCH, 64, 4, 693, 701

  DOI
• The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Yamanouchi Sakuya;Adachi Takuya;Yoshida Yukari;Rhone Jordan;Mao Jian-Hua;Fujiwara Keigi;Saganti Premkumar B.;Takahashi Akihisa;Hada Megumi, 2021, Biological Sciences in Space, 35, 0, 15, 23

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• Partial liver irradiation in rats induces the hypertrophy of nonirradiated liver lobes through hepatocyte proliferation†., Adachi Takuya;Yoshida Yukari;Shibuya Kei;Sato Ken;Yamazaki Yuichi;Kakizaki Satoru;Uraoka Toshio;Takahashi Akihisa, Journal of radiation research, 64, 4

  DOI
• Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity., Malatesta Polina;Kyriakidis Konstantinos;Hada Megumi;Ikeda Hiroko;Takahashi Akihisa;Saganti Premkumar B;Georgakilas Alexandros G;Michalopoulos Ioannis, Jan. 2024, Biomolecules, 14, 1

  DOI
• 疑似微小重力環境での放射線照射によるリンパ芽球細胞における染色体異常頻度の増加(Increased chromosome aberrations in lymphoblastoid cells exposed to radiation under simulated microgravity), ;;;, Nov. 2019, 62回, 101
• 宇宙放射線研究のすすめ　月や火星の低重力と低線量率放射線の複合環境模擬装置の開発(Recommendations for Space Radiation Research　Development of combined-environment simulator for low-dose-rate radiation and partial gravity of Moon and Mars), ;;;;;;;;;;;;;;;, Oct. 2020, 63回, 22
• 高LET線ならびに放射線類似薬により誘発されるDNA二本鎖切断の修復における修復経路の重要度の解析(Requirement of DNA double-strand break repair pathways for repairing high LET radiation- and radiomimetic agents-induced DNA damage), ;;;;, Oct. 2020, 63回, 75
• 【宇宙生命科学の進歩と医学応用への展望】総論　深宇宙での宇宙放射線リスク管理のための研究, 高橋 昭久, Nov. 2021, 279, 6, 550
• X線照射後の代償性肝肥大, ;;;;, Aug. 2021, 71, 3, 237
• 宇宙空間、月、火星を模擬した低重力と低線量率中性子線同時曝露による染色体異常誘導(Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons simulating outer space, the Moon, and Mars), ;;, Sep. 2022, 65回, 88
• FLASH炭素イオン照射による細胞実験(第一報)(First trial of cell experiments with FLASH carbon-ion irradiation), ;;;;;;;, Sep. 2022, 65回, 102
• 生物学的視点からみたハイパーサーミア, ;, Aug. 2022, 38, Suppl., 036
• Combined Environment Simulator for Low-Dose-Rate Radiation and Partial Gravity of Moon and Mars., Takahashi Akihisa;Yamanouchi Sakuya;Takeuchi Kazuomi;Takahashi Shogo;Tashiro Mutsumi;Hidema Jun;Higashitani Atsushi;Adachi Takuya;Zhang Shenke;Guirguis Fady Nagy Lotfy;Yoshida Yukari;Nagamatsu Aiko;Hada Megumi;Takeuchi Kunihito;Takahashi Tohru;Sekitomi Yuji, Nov. 2020, Life (Basel, Switzerland), 10, 11

  DOI
• Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b., Kim Eun Ho;Kim Jeong Yub;Kim Mi-Sook;Vares Guillaume;Ohno Tatsuya;Takahashi Akihisa;Uzawa Akiko;Seo Seung-Jun;Sai Sei, Dec. 2020, American journal of cancer research, 10, 12
• Hibernation as a Tool for Radiation Protection in Space Exploration., Puspitasari Anggraeini;Cerri Matteo;Takahashi Akihisa;Yoshida Yukari;Hanamura Kenji;Tinganelli Walter, Jan. 2021, Life (Basel, Switzerland), 11, 1

  DOI
• Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment., Zhang Shenke;Ueno Daishin;Ohira Takashi;Kato Hisashi;Izawa Tetsuya;Yamanouchi Sakuya;Yoshida Yukari;Takahashi Akihisa;Ohira Yoshinobu, Jul. 2021, Frontiers in cell and developmental biology, 9

  DOI
• Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells., Beheshti Afshin;McDonald J Tyson;Hada Megumi;Takahashi Akihisa;Mason Christopher E;Mognato Maddalena, Sep. 2021, International journal of molecular sciences, 22, 19

  DOI
• Th Balance-Related Host Genetic Background Affects the Therapeutic Effects of Combining Carbon-Ion Radiation Therapy With Dendritic Cell Immunotherapy., Ma Liqiu;Sakamoto Yoshimitsu;Ando Ken;Fujita Hidetoshi;Takahashi Akihisa;Takeshima Tsuguhide;Otsuka Hiromi;Ebner Daniel K;Kakimi Kazuhiro;Imai Takashi;Shimokawa Takashi, Nov. 2021, International journal of radiation oncology, biology, physics, 112, 3

  DOI
• 64Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity., Nachankar Ankita;Oike Takahiro;Hanaoka Hirofumi;Kanai Ayaka;Sato Hiro;Yoshida Yukari;Obinata Hideru;Sakai Makoto;Osu Naoto;Hirota Yuka;Takahashi Akihisa;Shibata Atsushi;Ohno Tatsuya, Dec. 2021, Cancers, 13, 24

  DOI
• Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector., Ju Zhenlin;Thomas Tamlyn N;Chiu Yi-Jen;Yamanouchi Sakuya;Yoshida Yukari;Abe Jun-Ichi;Takahashi Akihisa;Wang Jing;Fujiwara Keigi;Hada Megumi, May 2022, International journal of molecular sciences, 23, 11

  DOI
• A new type of simulated partial gravity apparatus for rats based on a pully-spring system., Zhang Shenke;Adachi Takuya;Zhang Shengli;Yoshida Yukari;Takahashi Akihisa, Aug. 2022, Frontiers in cell and developmental biology, 10

  DOI
• Synthetic torpor protects rats from exposure to accelerated heavy ions., Puspitasari Anggraeini;Squarcio Fabio;Quartieri Martina;Totis Cristina;Hitrec Timna;Takahashi Akihisa;Yoshida Yukari;Hanamura Kenji;Yako Tomoko;Cerri Matteo;Simoniello Palma;Durante Marco;Tinganelli Walter, Sep. 2022, Scientific reports, 12, 1

  DOI
• X線照射後の代償性肝肥大, ;;;;, Aug. 2021, 71, 3, 237
• 生物学的視点からみたハイパーサーミア, ;, Aug. 2022, 38, Suppl., 036
• Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody, Liqiu Ma; Yang Li; Yoshimitsu Sakamoto; Lin Xie; Saaya Suzuki; Yukari Yoshida; Li Sui; Gang Guo; Jialing Wen; Wangcai Ren; Kazuhiro Kakimi; Kensuke Osada; Akihisa Takahashi; Takashi Shimokawa, Nov. 2024, Neoplasia, Scientific journal
• Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles, Shengli Zhang; Shenke Zhang; Zhen Wang; Takuya Adachi; Yukari Yoshida; Akihisa Takahashi, Aug. 2024, Life Sciences in Space Research, Scientific journal

  DOI
• Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 Apc/+ mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, May 2024, Life Sciences in Space Research, 41, 202, 209, Scientific journal

  DOI
• Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity, Polina Malatesta; Konstantinos Kyriakidis; Megumi Hada; Hiroko Ikeda; Akihisa Takahashi; Premkumar Saganti; Alexandros Georgakilas; Ioannis Michalopoulos, Jan. 2024, Biomolecules, 14, 1, 88, Scientific journal

  DOI
• Partial liver irradiation in rats induces the hypertrophy of non-irradiated liver lobes through hepatocyte proliferation, Takuya Adachi; Yukari Yoshida; Kei Shibuya; Ken Sato; Yuichi Yamazaki; Satoru Kakizaki; Toshio Uraoka; Akihisa Takahashi, 2023, J Radiat Res, 64, 693, 701, Scientific journal
• Synthetic torpor protects rats from exposure to accelerated heavy ions, Anggraeini Puspitasari; Fabio Squarcio; Martina Quartieri; Cristina Totis; Timna Hitrec; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Tomoko Yako; Matteo Cerri; Palma Simoniello; Marco Durante; Walter Tinganelli, 30 Sep. 2022, Scientific Reports, 12, 1, 16405, 16405, Scientific journal

  DOI
• A new type of simulated partial gravity apparatus for rats based on a pully-spring system, Shenke Zhang; Takuya Adachi; Shengli Zhang; Yukari Yoshida; Akihisa Takahashi, Aug. 2022, Front Cell Dev Biol ., 10, 965656, Scientific journal

  DOI
• Adaptation and Changes in Actin Dynamics and Cell Motility as Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector, Zhenlin Ju; Tamlyn Thomas; Yi-Jen Chiu; Sakuya Yamanouchi; Yukari Yoshida; Jun-ichi Abe; Akihisa Takahashi; Jing Wang; Keigi Fujiwara; Megumi Hada, May 2022, International Journal of Molecular Sciences, 23, 6127, Scientific journal

  DOI
• ⁶⁴Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity, ANKITA NACHANKAR; Takahiro Oike; Hirofumi Hanaoka; Ayaka Kanai; Hiro Sato; Yukari Yoshida; Hideru Obinata; Makoto SAKAI; Naoto Osu; Yuka Hirota; Akihisa Takahashi; Atsushi Shibata; Tatsuya Ohno, Dec. 2021, Cancers, Scientific journal

  DOI
• Th balance related host genetic background affects the therapeutic effects of combining carbon-ion radiotherapy with dendritic cell immunotherapy, Liqiu Ma; Yoshimitsu Sakamoto; Ken Ando; Hidetoshi Fujita; Akihisa Takahashi; Tsuguhide Takeshima; Hiromi Otsuka; Daniel K Ebner; Kazuhiro Kakimi; Takashi Imai; Takashi Shimokawa, Nov. 2021, Int J Radiat Oncol Biol Phys, 112, 3, 3780, 789, Scientific journal

  DOI
• The combined effect of simulated microgravity and radiation on chromosome aberrations in human peripheral blood lymphocytes, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, Jul. 2021, Biological Sciences in Space, 35, 15, 23, Scientific journal

  DOI
• Depression of Bone Density at the Weight-bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated with a Partial Gravity Environment, Shenke Zhang; Daishin Ueno; Takashi Ohira; Hisashi Kato; Tetsuya Izawa; Sakuya Yamanouchi; Yukari Yoshida; Akihisa Takahashi; Yoshinobu Ohira, Jun. 2021, Frontiers in Cell and Development Biology, 9, 707470, Scientific journal
• Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations, Sakuya Yamanouchi; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, Sep. 2020, Life, 10, 9, 187, Scientific journal

  DOI
• Inhibition of the ATR kinase enhances 5-FU sensitivity independently of non-homologous end-joining and homologous recombination repair pathways., Soichiro S Ito; Yosuke Nakagawa; Masaya Matsubayashi; Yoshihiko M Sakaguchi; Shinko Kobashigawa; Takeshi K Matsui; Hitoki Nanaura; Mari Nakanishi; Fumika Kitayoshi; Sotaro Kikuchi; Atsuhisa Kajihara; Shigehiro Tamaki; Kazuma Sugie; Genro Kashino; Akihisa Takahashi; Masatoshi Hasegawa; Eiichiro Mori; Tadaaki Kirita, 16 Jul. 2020, J Biol Chem, 295, 37, 12946, 12961, Scientific journal

  DOI
• Carbon-Ion Beam Irradiation Alone or in Combination with Zoledronic acid Effectively Kills Osteosarcoma Cells, Eun Ho Kim; Mi-Sook Kim; Akihisa Takahashi; Masao Suzuki; Guillaume Vares; Akiko Uzawa; Akira Fujimori; Tatsuya Ohno; Sei Sai, Mar. 2020, Cancers, 12, 698, Scientific journal

  DOI
• Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells, Ju Yeon Oh; Eun Ho Kim; Yeon-Joo Lee; Sei Sai; Sun Ha Lim; Jang Woo Park; Hye Kyung Chung; Joon Kim; Guillaume Vares; Akihisa Takahashi; Youn Kyoung Jeong; Mi-Sook Kim; Chang-Bae Kong, Nov. 2019, Cancers, 11, 1812, Scientific journal

  DOI
• X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity, Anggraeini Puspitasari; Hiroyuki Yamazaki; Hidemasa Kawamura; Takashi Nakano; Akihisa Takahashi; Tomoaki Shirao; Kathryn Held, Nov. 2019, Neuroscience Research, S0168-0102, 19, 30320, 30327, Scientific journal
• Anti-Metastatic Benefits Produced by Hyperthermia and a CCL3 Derivative, Liqiu Ma; Ryosuke Kambe; Tomoko Tsuchiya; Shiro Kanegasaki; Akihisa Takahashi, Nov. 2019, Cancers, 11, 11, 1770, Scientific journal

  DOI
• Melatonin is a potential drug for the prevention of bone loss during space flight, Mika Ikegame; Atsuhiko Hattori; Makoto J. Tabata; Kei-ichiro Kitamura; Yoshiaki Tabuchi; Yukihiro Furusawa; Yusuke Maruyama; Tatsuki Yamamoto; Toshio Sekiguchi; Risa Matsuoka; Taizo Hanmoto; Takahiro Ikari; Masato Endo; Katsunori Omori; Masaki Nakano; Sayaka Yashima; Sadakazu Ejiri; Toshiki Taya; Hiroshi Nakashima; Nobuaki Shimizu; Masahisa Nakamura; Takashi Kondo; Kazuichi Hayakawa; Ichiro Takasaki; Atsushi Kaminishi; Ryosuke Akatsuka; Yuichi Sasayama; Takumi Nishiuchi; Masayuki Nara; Hachiro Iseki; Vishwajit S. Chowdhury; Shigehito Wada; Kenichi Ijiri; Toshio Takeuchi; Tohru Suzuki; Hironori Ando; Kouhei Matsuda; Masanori Somei; Hiroyuki Mishima; Yuko Mikuni-Takagaki; Hisayuki Funahashi; Akihisa Takahashi; Yoshinari Watanabe; Masahiro Maeda; Hideaki Uchida; Akio Hayashi; Akira Kambegawa; Azusa Seki; Sachiko Yano; Toru Shimazu; Hiromi Suzuki; Jun Hirayama; Nobuo Suzuki, Oct. 2019, Journal of Pineal Research, 67, 3, e12594, Scientific journal

  DOI
• Expression profile of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida; Akihisa Takahashi, Sep. 2019, International Journal of Molecular Science, 20, 19, 4791, Scientific journal

  DOI
• Effects of p53 status of tumor cells and combined treatment with mild hyperthermia, wortmannin or caffeine on recovery from radiation-induced damage., Shin-Ichiro Masunaga; Keizo Tano; Yu Sanada; Minoru Suzuki; Akihisa Takahashi; Ken Ohnishi; Koji Ono, Jun. 2019, World Journal of Oncology, 10, 3, 132, 141, Scientific journal

  DOI
• Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Hiroko Ikeda; Jordan R. Rhone; Andrew J. Beitman; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn D. Held; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi, Dec. 2018, International Journal of Molecular Sciences, 20, 43, Scientific journal

  DOI
• Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice, Akihisa Takahashi; Shoto Wakihata; Liqiu Ma; Takuya Adachi; Hiroki Hirose; Yukari Yoshida; Yoshinobu Ohira, Dec. 2018, International Journal of Molecular Sciences, 19, 3959, Scientific journal

  DOI
• X-ray irradiation induces disruption of the blood–brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain, Yukari Yoshida; Yukihiko Sejimo; Masashi Kurachi; Yasuki Ishizaki; Takashi Nakano; Akihisa Takahashi, Oct. 2018, Neurochemistry International, 119, 199, 206, Scientific journal

  DOI
• In vivo and in vitro immunochemical assay for CNS synaptic dysfunction by X-irradiation, Shirao Tomoaki; Puspitasari Anggraeini; Koganezawa Noriko; Kawamura Hidemasa; Takahashi Akihisa; Sekino Yuko; Nakano Takashi; Held Kathryn D, Sep. 2018, JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 93, 136

  DOI
• BRCA2 protects mammalian cells from heat shock., Yosuke Nakagawa; Atsuhisa Kajihara; Akihisa Takahashi; Akiho S Murata; Masaya Matsubayashi; Soichiro S Ito; Ichiro Ota; Takahiko Nakagawa; Masatoshi Hasegawa; Tadaaki Kirita; Takeo Ohnishi; Eiichiro Mori, Sep. 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 34, 6, 795, 801, Scientific journal

  DOI
• Takeo Ohnishi, PhD, 1944-2017, Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi; Hideki Matsumoto, 01 Oct. 2017, Radiation research, 188, 4, 465, 467, Scientific journal

  DOI
• Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system, Hiroko Ikeda; Hikaru Souda; Anggraeini Puspitasari; Kathryn D. Held; Jun Hidema; Takeshi Nikawa; Yukari Yoshida; Tatsuaki Kanai; Akihisa Takahashi, 01 Feb. 2017, Life Sciences in Space Research, 12, 51, 60, Scientific journal

  DOI
• Future Scenario of the Space Radiation Research Using Space Environment, Akihisa Takahashi; Jun Hidema; Hiroshi Yasuda, 2017, INTERNATIONAL JOURNAL OF MICROGRAVITY SCIENCE AND APPLICATION, 34, 2, Scientific journal

  DOI
• Targeting of carbon ion-induced G2 checkpoint activation in lung cancer cells using Wee-1 inhibitor MK-1775, Hongyu Ma; Akihisa Takahashi; Yukihiko Sejimo; Akiko Adachi; Nobuteru Kubo; Mayu Isono; Yukari Yoshida; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Dec. 2015, Radiation Research, 184, 6, 660, 669, Scientific journal

  DOI
• Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells, Hongyu Ma; Akihisa Takahashi; Yukari Yoshida; Akiko Adachi; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Nov. 2015, RADIATION ONCOLOGY, 10, 225, Scientific journal

  DOI
• Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells, Mayu Isono; Yukari Yoshida; Akihisa Takahashi; Takahiro Oike; Atsushi Shibata; Yoshiki Kubota; Tatsuaki Kanai; Tatsuya Ohno; Takashi Nakano, Sep. 2015, JOURNAL OF RADIATION RESEARCH, 56, 5, 856, 861, Scientific journal

  DOI
• ヒト膵臓がん細胞におけるPTK6によるX線誘導遊走・浸潤能の亢進, 小町 麻由美; 尾池 貴洋; 野田 真永; 鈴木 義行; 中野 隆史; 高橋 昭久, May 2015, 65, 2, 167, 167
• Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460, Nobuteru Kubo; Shin-ei Noda; Akihisa Takahashi; Yukari Yoshida; Takahiro Oike; Kazutoshi Murata; Atsushi Musha; Yoshiyuki Suzuki; Tatsuya Ohno; Takeo Takahashi; Takashi Nakano, Mar. 2015, JOURNAL OF RADIATION RESEARCH, 56, 2, 229, 238, Scientific journal

  DOI
• 神経幹細胞および神経膠芽腫細胞における増殖率を指標としたX線および炭素線の感受性, 磯野 真由; 吉田 由香里; 八高 知子; 高橋 昭久; 尾池 貴洋; 柴田 淳史; 金井 達明; 大野 達也; 中野 隆史, Sep. 2014, 57回, 130, 130
• Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation, Akihisa Takahashi; Makoto Kubo; Hongyu Ma; Akiko Nakagawa; Yukari Yoshida; Mayu Isono; Tatsuaki Kanai; Tatsuya Ohno; Yoshiya Furusawa; Tomoo Funayama; Yasuhiko Kobayashi; Takashi Nakano, Sep. 2014, Radiation Research, 182, 3, 338, 344, Scientific journal

  DOI
• Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells, Kazutoshi Murata; Shin-ei Noda; Takahiro Oike; Akihisa Takahashi; Yukari Yoshida; Yoshiyuki Suzuki; Tatsuya Ohno; Tomoo Funayama; Yasuhiko Kobayashi; Takeo Takahashi; Takashi Nakano, Jul. 2014, Journal of Radiation Research, 55, 4, 658, 664, Scientific journal

  DOI
• 肺腺癌細胞における炭素線誘発遊走能増加と遊走能に対するROCK阻害剤の抑制作用ついて, 村田 和俊; 野田 真永; 尾池 貴洋; 高橋 昭久; 吉田 由香里; 鈴木 義行; 大野 達也; 舟山 知夫; 小林 泰彦; 高橋 健夫; 中野 隆史, Jun. 2014, 49, 3, 1696, 1696
• The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells, Yosuke Nakagawa; Atsuhisa Kajihara; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Tadaaki Kirita; Takeo Ohnishi, May 2014, ONCOLOGY REPORTS, 31, 5, 2001, 2006, Scientific journal

  DOI
• Degradation of initiator tRNA(Met) by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells, Kazunori Watanabe; Ryu Miyagawa; Chie Tomikawa; Rie Mizuno; Akihisa Takahashi; Hiroyuki Hori; Kenichi Ijiri, Apr. 2013, NUCLEIC ACIDS RESEARCH, 41, 8, 4671, 4685, Scientific journal

  DOI
• Expression of p53-Regulated Proteins in Human Cultured Lymphoblastoid TSCE5 and WTK1 Cell Lines during Spaceflight, Akihisa Takahashi; Hiromi Suzuki; Katsunori Omori; Masaya Seki; Toko Hashizume; Toru Shimazu; Noriaki Ishioka; Takeo Ohnishi, Mar. 2012, JOURNAL OF RADIATION RESEARCH, 53, 2, 168, 175, Scientific journal

  DOI
• DNA Double-Strand Breaks Induced by Cavitational Mechanical Effects of Ultrasound in Cancer Cell Lines, Yukihiro Furusawa; Yoshisada Fujiwara; Paul Campbell; Qing-Li Zhao; Ryohei Ogawa; Mariame Ali Hassan; Yoshiaki Tabuchi; Ichiro Takasaki; Akihisa Takahashi; Takashi Kondo, Jan. 2012, PLOS ONE, 7, 1, e29012, Scientific journal

  DOI
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G(2)/M Phase-dependent, Xiaoming Su; Akihisa Takahashi; Natsuko Kondo; Yosuke Nakagawa; Toshiyasu Iwasaki; Guozhen Guo; Takeo Ohnishi, Sep. 2011, JOURNAL OF RADIATION RESEARCH, 52, 5, 609, 615, Scientific journal

  DOI
• Heat induces gamma H2AX foci formation in mammalian cells, Akihisa Takahashi; Eiichiro Mori; Georgios I. Somakos; Ken Ohnishi; Takeo Ohnishi, Oct. 2008, MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 656, 1-2, 88, 92, Scientific journal

  DOI
• Proposal from space radiation biologists. Importance of Centrifuge Facility in the study of biological effect by space radiation, A. Takahashi; T. Ohnishi, 2001, Biological sciences in space = Uchū seibutsu kagaku, 15, 3, 167, 171, Scientific journal

  DOI
• Space radiation biology, A. Takahashi; T. Ohnishi, 2001, Biological sciences in space = Uchū seibutsu kagaku, 15, 1, 40, 46, Scientific journal

  DOI
• Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress, H Matsumoto; A Takahashi; XJ Wang; K Ohnishi; T Ohnishi, Aug. 1997, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 39, 1, 197, 203, Scientific journal

MISC

• Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Jun Hirayama;Atsuhiko Hattori;Akihisa Takahashi;Yukihiro Furusawa;Yoshiaki Tabuchi;Masahiro Shibata;Aiko Nagamatsu;Sachiko Yano;Yusuke Maruyama;Hajime Matsubara;Toshio Sekiguchi;Nobuo Suzuki, 06 Oct. 2022, J Pineal Res ., Introduction scientific journal

  DOI
• Study for Managing Space Radiation Risk in Deep Space, Akihisa Takahashi, Nov. 2021, Igaku no ayumi, 279, 6, 550, 554, Introduction commerce magazine
• Genomic changes driven by radiation-induced DNA damage and microgravity in human cells, Afshin Beheshti , J. Tyson McDonald , Megumi Hada , Akihisa , Takahashi , Christopher E Mason , Maddalena Mognato, 29 Sep. 2021, Int J Mol Sci., 22, 19, 10507

  DOI
• Hibernation as a tool for radiation protection in space exploration, Anggraeini Puspitasari; Matteo Cerri; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Walter Tinganelli, Jan. 2021, Life, 11, 54, Introduction scientific journal
• Space radiation biology for “Living in Space”, Satoshi Furukawa; Aiko Nagamatsu; Mitsuru Nenoi; Akira Fujimori; Shizuko Kakinuma; Takanori Katsube; Bing Wang; Chizuru Tsuruoka; Toshiyuki Shirai; Asako J. Nakamura; Asako Sakaue-Sawano; Atsushi Miyawaki; Hiroshi Harada; Minoru Kobayashi; Junya Kobayashi; Takekazu Kunieda; Tomoo Funayama; Michiyo Suzuki; Tatsuo Miyamoto; Jun Hidema; Yukari Yoshida; Akihisa Takahashi, Mar. 2020, BioMed Research International, 2020, 4703286, 4703286, Introduction scientific journal

  DOI
• How does spaceflight affect the acquired immune system?, Taishin Akiyama; Kenta Horie; Eiichi Hinoi; Manami Hiraiwa; Akihisa Kato; Yoichi Maekawa; Akihisa Takahashi; Satoshi Furukawa, 2020, NPJ microgravity, 6, 14, 14, Introduction scientific journal

  DOI
• 宇宙を模擬した放射線と微小重力の複合曝露による染色体異常の増加., 髙橋昭久; 藤原敬己; 秦恵, Feb. 2019, 51, 2, 24, 27, Introduction commerce magazine
• Role of High-Linear Energy Transfer Radiobiology in Space Radiation Exposure Risks, Akihisa Takahashi; Hiroko Ikeda; Yukari Yoshida, Aug. 2018, International Journal of Particle Therapy, 5, 1, 151, 159, Introduction scientific journal

  DOI
• 宇宙放射線と無重力の複合影響., 髙橋昭久; 吉田由香里; 脇畑庄人; 大平充宣, Oct. 2018, 50, 591, 596, Introduction commerce magazine
• 宇宙放射線と重力変化環境の複合影響, 髙橋昭久; 池田裕子; 吉田由香里, Apr. 2018, 69, 2, 152, 156, Introduction commerce magazine
• 宇宙環境を利用した宇宙放射線研究の将来シナリオ, 髙橋昭久, Apr. 2017, 34, 2, 340203, Introduction scientific journal
• ヒト膵癌細胞におけるLPA受容体を介した遊走・浸潤と放射線治療戦略, 小町麻由美; 野田真永; 村田和俊; 中野隆史; 高橋昭久; 岡本雅彦; 鈴木義行, 2016, Kitakanto Medical Journal, 66, 4, 297(J‐STAGE)

  DOI
• Effects of charged particles on human tumor cells, Kathryn D. Held; Hidemasa Kawamura; Takuya Kaminuma; Athena Evalour S. Paz; Yukari Yoshida; Qi Liu; Henning Willers; Akihisa Takahashi, 2016, Frontiers in Oncology, 6, 23, Book review

  DOI
• 粒子線がん治療：放射線生物学的展望, 髙橋昭久; 吉田由香里, Jun. 2015, 64, 6, 371, 381, Introduction scientific journal
• ヒト膵癌細胞においてKi16425は放射線感受性を高めるか～新たな分子標的薬の可能性～, 小町 麻由美; 野田 真永; 村田 和俊; 鈴木 義行; 中野 隆史; 岡本 雅彦; 高橋 昭久, 01 May 2015, 65, 2, 171, 172
• Therapeutic strategies for head and neck cancer based on p53 status (Review), Ichiro Ota; Noritomo Okamoto; Katsunari Yane; Akihisa Takahashi; Takashi Masui; Hiroshi Hosoi; Takeo Ohnishi, Apr. 2012, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 3, 4, 585, 591, Book review

  DOI
• 2011年度生物科学系スモールペイロード宇宙実験研究チーム活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2012, 宇宙利用シンポジウム, 28th, 185, 186
• 2010年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2011, 宇宙利用シンポジウム, 27th, 219, 220
• 中性子捕捉療法によって誘導されるDNAリガーゼIV修復不能なDNA損傷, 近藤夏子; 増永慎一郎; 高橋昭久; 鈴木実; 森英一朗; 仲川洋介; 小野公二; 長谷川正俊; 大西武雄, 2011
• 二本鎖切断(DSB)修復経路を分子標的とする中性子捕捉療法の増感の検討, 近藤夏子; 増永慎一郎; 高橋昭久; 森英一朗; 鈴木実; 木梨友子; 劉勇; 長谷川正俊; 大西武雄; 小野公二, 2011
• Signal Transduction of Radiation and/or Hyperthermic Cancer Therapies, Takeo Ohnishi; Akihisa Takahashi, Sep. 2010, CURRENT SIGNAL TRANSDUCTION THERAPY, 5, 3, 231, 236, Book review
• 平成21年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 夏井坂誠; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 永瀬睦; 嶋津徹; 村瀬浩史; 行徳淳一郎; GUSEV Oleg; 山崎丘; 石岡憲昭, Mar. 2010, 宇宙利用シンポジウム, 26th, 201, 202
• Molecular Mechanisms Involved in Adaptive Responses to Radiation, UV light, and Heat, Akihisa Takahashi; Takeo Ohnishi, Sep. 2009, JOURNAL OF RADIATION RESEARCH, 50, 5, 385, 393, Book review

  DOI
• アルキル化剤によるDNA損傷修復メカニズムとそのがん治療への応用, 近藤夏子; 髙橋昭久; 大西武雄, 2009, 44, 2, 140, 153
• Expression of p53-regulated genes in cultured mammalian cells after exposure to a space environment., Ohnishi T; Takahashi A; Suzuki H; Omori K; Shimazu T; Ishioka N, 2009, Biol Sci Space., 23, 3, 10, Introduction scientific journal
• LOH analyses for biological effects of space radiation: human cell culture in “Kibo” of International Space Station., Yatagai F; Takahashi A; Honma M; Suzuki H; Omori K; Seki M; Hashizume T; Shimazu T; Enomoto S; Ohnishi T; Ishioka N, 2009, 23, 11, 16

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• Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes (vol 24, pg 605, 2008), A. Kajihara; A. Takahashi; K. Ohnishi; Y. Imai; N. Yamakawa; J. Yasumoto; T. Ohnishi; T. Kirita, 2009, INTERNATIONAL JOURNAL OF HYPERTHERMIA, 25, 5, 403, 404, Others

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• 温熱誘導DNA二本鎖切断の生物学(The Biology of Heat-Induced DNA Double-Strand Breaks), 森 英一朗; 高橋 昭久; 大西 武雄, Jun. 2008, Thermal Medicine, 24, 2, 39,(54), 50,(54)

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• p53 targeting can enhance cancer therapy via radiation, heat and anti-cancer agents, Takeo Ohnishi; Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi, Jun. 2008, ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 8, 5, 564, 570, Book review
• 平成19年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 最上善広; 永瀬睦; 嶋津徹; 藤本信義; 山崎丘; 石岡憲昭, Mar. 2008, 宇宙利用シンポジウム, 24th, 337, 338
• "きぼう"での生物実験に向けてLOH解析による宇宙放射線の生物影響の検討, 谷田貝文夫; 髙橋昭久; 本間正充; 鈴木ひろみ; 大森克徳; 関真也; 橋爪藤子; 嶋津徹; 榎本秀一; 大西武雄; 石岡憲昭, 2008, 25, 695, 700
• ほ乳動物培養細胞における宇宙環境暴露後のp53調節遺伝子群の遺伝子発現, 大西武雄; 髙橋昭久; 鈴木ひろみ; 嶋津徹; 大森克徳; 石岡憲昭, 2008, 25, 686, 690
• 放射線適応応答のしくみの再考, 大西武雄; 髙橋昭久, 2008, 43, 1, 91, 99
• 放射線・紫外線・温熱に対する適応応答―その分子機構―, 髙橋昭久; 大西武雄, 2008, 43, 4, 409, 423
• Vanguards of paradigm shift in radiation biology: Radiation-induced adaptive and bystander responses, Hideki Matsumoto; Nobuyuki Hamada; Akihisa Takahashi; Yasuhiko Kobayashi; Takeo Ohnishi, Mar. 2007, JOURNAL OF RADIATION RESEARCH, 48, 2, 97, 106, Book review

  DOI
• 線虫(C.elegans)を用いる回収衛星宇宙実験研究班WG活動報告, 石岡憲昭; 石原昭彦; 宇佐美真一; 高橋昭久; 夏井坂誠; 二川健; 東谷篤志; 東端晃; 藤本信義; 馬嶋秀行; 保田浩志; 山崎丘, Mar. 2007, 宇宙利用シンポジウム, 23rd, 340, 341
• 平成18年度生物科学系スモールペイロード宇宙実験研究班WG活動報告, 東端晃; 福井啓二; 高橋秀幸; 東谷篤志; 馬嶋秀行; 曽我部正博; 高橋昭久; 二川健; 最上善広; 永瀬睦; 嶋津徹; 藤本信義; 山崎丘; 石岡憲昭, Mar. 2007, 宇宙利用シンポジウム, 23rd, 342, 343
• Does gamma H2AX foci formation depend on the presence of DNA double strand breaks? (vol 229, pg 171, 2005), A Takahashi; T Ohnishi, May 2006, CANCER LETTERS, 236, 1, 155, 156, Others

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• What is the critical hyperthermia target in cancer cells?, Takahashi A; Ohnishi T, 2006, Jpn J Hyperthermic Oncol (Thermal Med)., 22, 229, 237, Introduction scientific journal
• Does gamma H2AX foci formation depend on the presence of DNA double strand breaks?, A Takahashi; T Ohnishi, Nov. 2005, CANCER LETTERS, 229, 2, 171, 179, Book review

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• A possible role of DNA double strand breaks in heat-induced cell killing - In response, A Takahashi; E Mori; T Ohnishi, Nov. 2005, CANCER RESEARCH, 65, 22, 10633, 10633, Report scientific journal
• 宇宙放射線の生物影響研究の意義: 微小重力と放射線影響との相互作用に関する研究の新たな展開, 大西武雄; 髙橋昭久, 2005, 22, 151, 154
• 温熱による細胞死とDNA二本鎖切断の生成, 髙橋昭久; 森英一朗; 大西武雄, 2005, 40, 139, 147
• p53の遺伝子型からみたがん細胞の炭素線感受性, 高橋昭久; 大西武雄; 松本英樹, 2004, -HIMAC10周年記念 研究成果要覧-, 131, 135
• Radiation-induced adaptive responses and bystander effects., Matsumoto H; Takahashi A; Ohnishi T, 2004, Biol Sci Space., 18, 247, 254, Introduction scientific journal
• The significance of the study about the biological effects of solar ultraviolet radiation using the Exposed Facility on the International Space Station., Takahashi A; Ohnishi T, 2004, Biol Sci Space., 18, 255, 260, Introduction scientific journal
• Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation, A. Takahashi; K. Ohnishi; T. Ohnishi, 2004, International Journal of Low Radiation, 1, 2, 199, 207

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• The role of p53 molecule in radiation and hyperthermic therapies, J Yasumoto; A Takahashi; K Ohnishi; T Ohnishi, Aug. 2003, JOURNAL OF HEALTH SCIENCE, 49, 4, 273, 277, Book review
• 低温度温熱処置及びp53 Statusが腫瘍内低酸素細胞分画の大きさに及ぼす影響, 増永慎一郎; 永田憲司; 高橋昭久; 大西健; 大西武雄; 木梨友子; 小野公二, 2003
• がん細胞に特徴的なシグナル伝達分子を標的とする薬剤, 幸和恵; 髙橋昭久; 大西武雄, 2003, 38, 3, 245, 259
• Pre-irradiation at a low dose-rate blunted p53 response, A Takahashi, Mar. 2002, JOURNAL OF RADIATION RESEARCH, 43, 1, 1, 9, Book review
• Radiobiological characteristics of solid tumors depending on the p53 status of the tumor cells -- reference to the response of intratumor quiescent cells., Masunaga S; Takahashi A; Ohnishi T; Takagaki M; Kinashi Y; Ono K, 2002, the 6th International Symposium on Predictive Oncology and Therapy, 0, 0
• DNAマイクロアレイを用いた放射線誘導アポトーシスの遺伝子解析, 家根旦有; 太田一郎; 幸和恵; 細井裕司; 髙橋昭久; 大西健; 大西武雄, 2002, 48, 324, 327
• 各種LET放射線による癌細胞の死型解析, 髙橋昭久; 大西健; 青木瑞穂; 古澤佳也; 大西武雄, 2002, 62, 3, 6
• Radiation biology in space: DNA damage and biological effects of space radiation., Ohnishi T; Takahashi A; Ohnishi K, 2002, J Photosci., 9, 37, 40, Introduction scientific journal
• Growth inhibition in transplanted human tongue tumors bearing different p53 gene status with X-ray or C-beam irradiation., Asakawa, I; H. Yoshimura; A. Takahashi; K. Ohnishi; H. Nakagawa; I. Ota; Y. Furusawa; T. Tamamoto; H. Ohishi; T. Ohnishi, 2002, 22, 2037, 2043
• p53遺伝子を先行指標とする放射線・温熱治療のための基礎的研究, 大西健; 高橋昭久; 大西武雄, 2002, 50, 56
• 宇宙放射線の生物影響研究におけるセントリフュージの重要性, 髙橋昭久; 大西武雄, 2001, 15, 167, 171
• 宇宙放射線生物学, 髙橋昭久; 大西武雄, 2001, 15, 40, 46
• あらかじめの低線量率放射線被曝による放射線誘導アポトーシスの軽減, 髙橋昭久; 大西武雄, 2001, 36, 4, 401, 412
• Biological effects of space radiation., Ohnishi T; Takahashi A; Ohnishi K, 2001, Biol Sci Space., 15, 203, 210, Introduction scientific journal
• グリセロールによる変異型p53癌細胞に対する放射線誘導アポトーシスの回復, 太田一郎; 家根旦有; 金田宏和; 宮原裕; 細井裕司; 髙橋昭久; 大西健; 大西武雄, 2000, 18, 156, 157
• 放射線治療効果を高める工夫―増感剤の作用機序と臨床応用について, 玉本哲郎; 髙橋昭久; 大西武雄, 2000, 35, 152, 163
• 放射線および温熱治療の増感―アポトーシスの増感を狙う, 太田一郎; 髙橋昭久; 大西健; 大西武雄, 2000, 35, 67, 79
• Unique postural control of upside-down swimming catfish, Synodontis nigriventris, not affected by the change of gravity., Akihisa Takahashi, 01 Jul. 2000, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, 7, 97, 98
• Enzymic chemical reaction under microgravity environment in space., Ohnishi T; Takahashi A; Ohnishi K; Nakano T; Nagaoka S, 2000, J Gravit Phys., 7, 69, 70
• Relationship between p53 status and amount of hsp72 induction in human cancer cell, A Tsubakimoto; K Ohnishi; A Takahashi; M Hatoko; T Muramatsu; T Shirai; T Ohnishi, Apr. 1999, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 112, 4, 589, 589, Summary international conference
• 舌扁平上皮癌細胞へのp53遺伝子導入によるシスプラチン・X線・温熱感受性の制御, 太田一郎; 家根旦有; 金田宏和; 宮原裕; 松永喬; 大西健; 髙橋昭久; 玉本哲郎; 大西武雄, 1999, 17, 108, 109
• 宇宙環境での生命活動, 髙橋昭久; 大西健; 大西武雄, 1999, 34, 1, 86, 97
• DNA Damage Formation and p53 Accumulation in Mammalian Cells Exposed to the Space Environment, OHNISHI Takeo; TAKAHASHI Akihisa; OHNISHI Ken; MATSUMOTO Hideki, 1999, Biological Sciences in Space, 13, 2, 82, 87

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• Behavior and development of animals in outer space., TAKAHASHI Akihisa; OHNISHI Ken; OHNISHI Takeo, 1999, KAGAKU TO SEIBUTSU, 37, 6, 404, 407

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• p53を中心としたシグナルトランスダクションにおけるpoly (ADP-ribose) polymeraseの役割, 髙橋昭久; 大西武雄, 1998, 33, 4, 338, 350
• The mechanism of hyperthermic enhancement of tumor growth inhibition by carbon-ion beams in esophageal cancer., Takahashi A; Wang X; Tamamoto T; Ohnishi K; Aoki H; Tsuji K; Furusawa Y; Yukawa O; Ohnishi T, 1998, 9, 117, 120
• 変異型p53を導入したヒト神経膠芽腫細胞A-172における温熱によるWAF1誘導シグナルトランスダクション, 大西健; 王新江; 高橋昭久; 大西武雄, 1998, 44, 183, 184
• 微小重環境下でのサカサナマズの姿勢制御様式とストレス, 大西健; 山本俊宏; 高橋昭久; 上田匡; 田仲広明; 大西武雄, 1998, 8, 15, 19
• 放射線感受性と癌関連遺伝子, 髙橋昭久; 大西武雄, 1997, 9, 1, 13
• ゲル移動度シフト法によるHSFおよびp53のDNA結合活性の測定, 大西健; 髙橋昭久; 松本英樹; 大西武雄, 1996, 31, 52, 61
• p53によるDNA損傷の認識とその役割, 髙橋昭久; 大西武雄, 1996, 31, 3, 232, 245
• ノーザン・RT-PCR法による形質発現の定量, 松本英樹; 大西健; 髙橋昭久; 大西武雄; 加納永一, 1995, 30, 286, 298
• ウエスタンブロット法によるp53量の解析, 髙橋昭久; 松本英樹; 大西武雄, 1995, 30, 105, 117
• LICHT-INDUCED ANTHOCYANIN REDUCES THE EXTENT OF DAMAGE TO DNA IN UV-IRRADIATED CENTAUREA-CYANUS CELLS IN CULTURE, T OHNISHI; A TAKAHASHI; K TAKEDA, Dec. 1992, MUTATION RESEARCH, 272, 3, 277, 277, Summary international conference
• Physiological consequences of space flight, including abnormal bone metabolism, space radiation injury, and circadian clock dysregulation: Implications of melatonin use and regulation as a countermeasure, Jun Hirayama, Atsuhiko Hattori, Akihisa Takahashi, Yukihiro Furusawa, Yoshiaki Tabuchi, Masahiro Shibata, Aiko Nagamatsu, Sachiko Yano, Yusuke Maruyama, Hajime Matsubara, Toshio Sekiguchi, Nobuo Suzuki, Oct. 2022, Journal of Pineal Research
• Study for Managing Space Radiation Risk in Deep Space, Akihisa Takahashi, Nov. 2021, 279, 6, 550, 554, Introduction commerce magazine
• Genomic Changes Driven by Radiation-Induced DNA Damage and Microgravity in Human Cells, Afshin Beheshti; John McDonald; Megumi Hada; Akihisa Takahashi; Christopher E Mason; Maddalena Mognato, Sep. 2021, International Journal of Molecular Sciences, Introduction scientific journal

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• Research on Combined Effects of Space Radiation and Variable Gravity, Takahashi Akihisa; Kambe Ryosuke; Suzuki Kenshi; Tsuruoka Chizuru; Morioka Takamitsu; Takeshima Tsuguhide; Yoshida Yukari; Nakamura Asako; Hada Megumi; Nagamatsu Aiko; Ohira Yoshinobu; Inatomi Yuko; Kakinuma Shizuko, Jan. 2020, 34
• 植物における宇宙での微小重力と模擬太陽光の複合影響研究—Combined Effects of Microgravity and Simulated Solar UV Radiation on Plant in Space, 日出間, 純; 髙橋, 昭久; 稲富, 裕光; Hidema, Jun; Takahashi, Akihisa; Inatomi, Yuko, Jan. 2019, 33
• Combined effects of variable gravity and simulated solar UV light on plant in space, Hidema Jun; Kitaya Yoshiaki; Takahashi Akihisa; Inatomi Yuko, Jan. 2018, 32
• 総合 基礎研究が導くがん治療の新戦略 炭素イオン線と樹状細胞併用による転移抑制効果における樹状細胞の遺伝的背景の影響, 馬 立秋; 坂本 慶充; 高橋 昭久; 吉田 由香里; 中野 隆史; 今井 高志; 下川 卓志, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, MS23, 5
• 腹腔原発血管周囲類上皮細胞腫に対し重粒子線治療を施行した１例, 中川 彰子; 馬 洪玉; 久保 誠; 中野 隆史; 高橋 昭久; 吉田 由香里; 金井 達明; 大野 達也, 01 May 2015, 65, 2, 165, 165
• 中性子捕捉療法によって誘導されるDNAligaseIVによって修復されないDNA損傷, 近藤夏子; 増永慎一郎; 高橋昭久; 鈴木実; 木梨友子; 櫻井良憲; 森英一朗; 長谷川正俊; 大西武雄; 小野公二, Nov. 2011, Summary national conference

  DOI
• ヒト甲状腺未分化がんにおけるNBS1標的siRNAの温熱増感効果(siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells), 岡本 倫朋; 高橋 昭久; 太田 一郎; 家根 旦有; 大西 健; 細井 裕司; 大西 武雄, Aug. 2010, 日本癌学会総会記事, 69回, 292, 292
• ラパマイシンは頭頸部癌細胞の増殖を抑制し、シスプラチン誘導アポトーシスを促進する(Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells), 太田 一郎; 高橋 昭久; 家根 旦有; 岡本 倫朋; 細井 裕司; 大西 武雄, Aug. 2010, 日本癌学会総会記事, 69回, 484, 484
• Snail 1はMT1-MMPおよびMT2-MMPを発現誘導し、がん細胞浸潤をin vivoにおいても促進させる(Snail1 induces the membrane-anchored collagenases, MT1-MMP and MT2-MMP, to drive cancer cell invasion programs in vivo), 太田 一郎; 家根 旦有; 高橋 昭久; 大西 武雄; 松浦 成昭; 細井 裕司, Aug. 2009, 日本癌学会総会記事, 68回, 442, 442
• The scientific aspects of hyperthermic cancer therapy, Akihisa Takahashi; Takeo Ohnishi, Nov. 2006, Biotherapy, 20, 6, 515, 520, Book review
• 放射線をかいくぐり生きる微生物 (特集=<極限>を生きる生物たち--海底から宇宙まで), 高橋 昭久; 大西 武雄, Aug. 2006, 76, 8, 824, 826
• 放射線適応応答のしくみを探る (低線量放射線影響研究--これまでの10年を振り返り今後の展開を考える), 大西 武雄; 高橋 昭久; 松本 英樹, Mar. 2006, 8, 10
• Pre-irradiation with a Low Dose-rate Depressed Radiation-induced Biological Effects (2), TAKAHASHI Akihisa; OHNISHI Ken; TACHIBANA Akira; KUNUGITA Naoki; NORIMURA Toshiyuki; OHNISHI Takeo, 01 Nov. 2002, 16, 3, 195, 196
• Study of Biological Response by Pre-irradiation at a Low Dose or a Low Dose-rate, OHNISHI Takeo; TAKAHASHI Akihisa; OHNISHI Ken, 01 Nov. 2002, 16, 3, 103, 104
• Accumulation of p53 and induction of apoptosis gene by low dose ionizing radiation and/or artificial gravity, OKAICHI Kumio; OKUMURA Yutaka; OHNISHI Ken; TAKASASHI Akihisa; OHINISHI Takeo, Sep. 1999, 13, 3, 242, 243
• Expression of tumor suppressor gene in cells after low dose or low dose rate irradiation, OHNISHI Takeo; OHNISHI Ken; TAKAHASHI Akihisa, Sep. 1999, 13, 3, 244, 245
• The effect of microgravity on induced mutation through DNA synthesis during space flight, TAKAHASHI Akihisa; OHNISHI Ken; FUKUI Mitsuyo; NAKANO Tamotsu; NAGAOKA Shunji; OHINISHI Takeo, Sep. 1999, 13, 3, 234, 235
• SOS response in X-ray- or UV-irradiated E. coli cells under microgravity, OHINISHI Ken; TAKAHASHI Akihisa; NAKANO Tamotsu; NAGAOKA Shunji; OHNISHI Takeo, Sep. 1999, 13, 3, 232, 233

Books etc

• 理科年表2021, Contributor, 30 Nov. 2020, 1174, 1123-1127, Dictionary or encycropedia, ISBN: 978-4-621-30561-4
• 放射線医科学の事典, Contributor, Dec. 2019
• 分子標的と患者の個別化 「臨床放射線生物学の基礎. 改定第4版」, 2013
• Biological Effects of Low Dose Radiation., 2000
• The Effects of Low and Very Low Doses of Ionizing Radiation on Human Health., 2000
• Exploring Future Research Strategies in Space Radiation Sciences., 2000
• Advances in Hyperthermic Oncology 2000., 2001
• Radiation and Homeostasis., 2002
• Molecular Mechanisms for Radiation-induced Cellular Response and Cancer Development., 2002
• Encyclopedia of Cancer, 2nd Edition., 2009
• 最新アポトーシス実験法., 1995
• 新アポトーシス実験法改訂第2版., 1999
• 重粒子線治療の基礎と臨床., 2000
• 癌・放射線療法2002., 2002
• 集学的癌治療の研究と臨床., 2002
• 低線量・低線量率放射線による生物影響発現., 2003
• HIMAC10年の歩み－HIMAC10周年記念研究成果要覧－., 2004
• 放射線医科学., 2006
• モデルが拓く放射線防護研究の新たな展開., 2007
• ハイパーサーミア－がん温熱療法ガイドブック－., 2008
• 温熱免疫療法－ハイパーサーミック・イムノロジー., 2008
• からだと光の事典., 2010
• 植物色素フラボノイド., 2012
• Heat-induced DNA Damage (Cellular Response to Physical Stress and Therapeutic Application), 2013
• HIMAC 20周年記念事業研究成果要覧, 2015
• Hyperthermic Oncology from Bench to Bedside (Chapter 3), 2016
• Hyperthermic Oncology from Bench to Bedside (Chapter 9), 2016
• 放射線医科学 ―生体と放射線・電磁波・超音波―, 2016
• 生体の科学, 2018
• 医学大辞典, 2018

Presentations

• Combined effects of radiation and simulated microgravity on intestinal tumorigeness in ApcMin/+ mice, Chizuru Tsuruoka;Kenshi Suzuki;Takamitsu Morioka;Hitomi Seo;Mari Ogawa;Ryosuke Kambe;Tatsuhiko Imaoka;Shizuko Kakinuma;Akihisa Takahashi, COSPAR2024, 19 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English, Busan, Korea, Republic of, International conference
• INCREASED CHROMOSOME ABERRATIONS IN HUMAN CELLS EXPOSED TO SIMULATED MICROGRAVITY AND RADIATION SIMULTANEOUSLY, Premkumar Saganti, Megumi Hada;Hiroko Ikeda;Ianik Plante;Jian-Hua Mao;Alexandros G. Georgakilas;Akihisa Takahashi, Ioannis Michalopoulos, COSPAR2024, 14 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English, Busan, Korea, Republic of, International conference
• 宇宙空間における新規メラトニン誘導体のウロコの骨代謝に対する効果と地 上における骨疾患モデル動物を用いた解析, 鈴木信雄，古澤之裕，田渕圭章，豊田賢治，関あずさ，高垣裕子，染井正徳，江尻貞一，池亀美華，黒田康平，関口俊男，松原 創，高橋昭久，平山 順，服部淳彦, 日本宇宙生物科学会第37回大会, 24 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference
• 消化管腫瘍モデルマウスを用いた​ 宇宙模擬環境による発がん影響評価​, 鈴木健之 、鶴岡千鶴 、森岡孝満、今岡達彦、髙橋昭久、柿沼志津子, 日本宇宙生物科学会第37回大会​, 23 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference
• Study of melatonin as an effective therapeutic agent for various diseases in astronauts, Nobuo Suzuki, Jun Hirayama, Akihisa Takahashi, Kouhei Kuroda, Natsuno Yasuda, Yoshiaki Tabuchi, Yukihiro Furusawa, Mika Ikegame, Kazuki Watanabe, Yusuke Maruyama, Hajime Matsubara, Takayoshi Nakano, Hiromi Kimura-Suda, Ryotaro Kawamura, Hiroyuki Mishima, Haruyasu Kato, Azusa Seki, Atsuhiko Hattori, SUS38, 16 Jan. 2024, 16 Jan. 2024, 17 Jan. 2024, Japanese, Japan, Domestic conference
• マウス急性皮膚反応における炭素イオン線超高線量率照射の影響, 吉田由香里;須田裕夢;田代 睦;遊佐 顕;中尾政夫;髙橋昭久;大野達也, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, Japanese, Japan, Domestic conference
• Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao;Yukari Yoshida;Hiromu Suda;Akihisa Takahashi;Tatsuya Ohno, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, English, Maebashi, Japan, Domestic conference
• 炭素線超高線量率照射によるがん細胞の細胞死および細胞周期に及ぼす影響, 須田裕夢;吉田由香里;髙橋昭久;大野達也, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, Japanese, Japan, Domestic conference
• Analysis of FLASH effect with carbon-ion beams in vivo study, Yukari Yoshida;Hiromu Suda;Mutsumi Tashiro;Ken Yusa;Masao Nakao;Akihisa Takahashi;Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference
• Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao;Yukari Yoshida;Hiromu Suda;Akihisa Takahashi;Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference
• Biological response of cancer cells to carbon FLASH irradiation, Hiromu Suda, Yukari Yoshida, Akihisa Takahashi, Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference
• Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice, Kenshi Suzuki, Chizuru Tsuruoka, Takamitsu Morioka, Hitomi Seo, Mari Ogawa, Ryosuke Kambe, Tatsuhiko Imaoka, Shizuko Kakinuma, Akihisa Takahashi, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference
• Differential gene expression in human fibroblasts using a Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity change (SwiNG), Polina Malatesta, Konstantinos Kyriakidis, Megumi Hada, Hiroko Ikeda, Akihisa Takahashi, Premkumar Saganti, Alexandros Georgakilas, Ioannis Michalopoulos, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English, Maebashi, Japan, International conference
• DIFFERENTIAL GENE EXPRESSION IN HUMAN FIBROBLASTS SIMULTANEOUSLY EXPOSED TO PARTIAL GRAVITY AND LOW DOSE-RATE NEUTRONS, P. Malatesta;K. Kyriakidis;M. Hada;H. Ikeda;A. Takahashi;P. B. Saganti;A. G. Georgakilas;I. Michalopoulos, NASA HRP meeting 2024, 16 Feb. 2024, English, Houston, United States, International conference
• Biological Combined Effects of Simultaneous Exposure to Low-dose-rate Radiation and Partial Gravity Simulation the Moon, A.Takahashi;J-H Mao;P.B.Saganti;M,Hada, 7th GLOBAl MOON VILLAGE WORKSHOP & SYMPOSIUM, 07 Dec. 2023, 06 Dec. 2023, 10 Dec. 2023, English, Okayama, Tottori, Japan, International conference
• 宇宙放射線の生物影響を探る, 髙橋 昭久, 2023年度日本アイソトープ協会シンポジウム, 01 Dec. 2023, 01 Dec. 2023, 01 Dec. 2023, Japanese, Japan, Domestic conference
• 「きぼう」利用宇宙実験のための右第5乳房脂肪体移植実験器具の開発, 髙橋 昭久, 日本宇宙生物科学会　第37回大会, 24 Sep. 2023, 22 Sep. 2023, 24 Sep. 2023, Japanese, Japan, Domestic conference
• Differential gene expression in human fibroblasts simultaneously exposed to radiation and simulated microgravity, P. Malatesta, H. Ikeda, A. Takahashi, M. Hada, A. G. Georgakilas, I. Michalopoulos, NASA HRP meeting2023, 09 Feb. 2023, English, Houston, United States, International conference
• Ground simulation experiment: Chromosome aberration frequencies due to space radiation exposure on the Moon and Mars, Akihisa Takahashi, Hiroko Ikeda, Jian-Hua Mao, Premkumar B. Saganti, Megumi Hada, ISRN2023, 04 Mar. 2023, English, Japan, Domestic conference
• 宇宙での放射線と重力変化の複合影響, 髙橋 昭久, 宇宙ユニットシンポジウム2023, 12 Feb. 2023, Japanese, Japan
• Chromosome aberration induction by simulation environment of outer space, Moon and Mars, Akihisa Takahashi, Hiroko Ikeda, Jian-Hua Mao, Premkumar B. Saganti, Megumi Hada, 第2回日本量子医科学会, 09 Dec. 2022, English, Japan, Domestic conference
• Deep space and mitochondria, Akihisa Takahashi, 第96回日本薬理学会年会, 02 Dec. 2022, English, Japan, Domestic conference
• ＦLASH炭素イオン線照射～第一報：システムの構築と培養細胞実験～, 吉田由香里, 田代睦, 尾池貴洋, 中尾政夫, 遊佐顕, 廣田由香, 髙橋昭久, 大野達也, 日本放射線腫瘍学会第35回学術大会, Nov. 2022, Japanese, Japan, Domestic conference
• Expression profile of cell cycle / aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, H. Ikeda, M. Hada, A. Takahashi, ASGSR2022, Nov. 2022, English, Houston, United States, International conference
• The early proteomic responses of cultured mammalian cells exposed to simulated microgravity, Zhenlin Ju, Jing Wang, Megumi Hada, Akihisa Takahashi, Keigi Fujiwara, ASGSR2022, Nov. 2022, English, Houston, United States, International conference
• Increases chromosome aberrations in human cells exposed simultaneously to simulated microgravity and neutron, M. Hada, H. Ikeda, P.B. Saganti, A. Takahashi, ASGSR2022, Nov. 2022, English, Houston, United States, International conference
• 量子科学技術と宇宙医学, 髙橋 昭久, 令和４年度量子医療推進講演会, 15 Oct. 2022, 15 Oct. 2022, 15 Oct. 2022, Japanese, Japan, Domestic conference
• Adenosine agonist treatment increases radioresistance in vitro and in vivo, Anggraeini Puspitasari;Matteo Cerri;Akihisa Takahashi;Yukari Yoshida;Kenji Hanamura;Martina Quartieri;Cristina Totis;Olga Sokol;Palma Simonello;Marco Durante;Walter Tinganelli, RRS2022, 17 Oct. 2022, 16 Oct. 2022, 19 Oct. 2022, English, Hawaii, United States, International conference
• Adenosine Agonist treatment shows protective effects to C-ion irradiation, Anggraeini Puspitasari;Matteo Cerri;Fabio Squarcio;Akihisa Takahashi;Yukari Yoshida;Kenji Hanamura;Martina Quartieri;Cristina Totis;Palma Simonello;Marco Durante;Walter Tinganelli, ERRS2022, 21 Sep. 2022, 21 Sep. 2022, 24 Sep. 2022, English, Catania, Italy, International conference
• The synergistic effects of radiation and simulated microgravity to expression profile changes of cell cycle / aging-related genes in human fibroblasts, Hiroko Ikeda;Megumi Hada;Akihisa Takahashi, 日本放射線影響学会第65回大会, 16 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, English, Osaka, Japan, Domestic conference
• First trial of cell experiments with FLASH carbon-ion irradiation, Yukari Yoshida;Mutsumi Tashiro;Takahiro Oike;Masao Nakao;Ken Yusa;Yuka Hirota;Akihisa Takahashi;Tatsuya Ohno, 日本放射線影響学会第65回大会, 16 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, English, Osaka, Japan, Domestic conference
• Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons simulating outer space, the Moon, and Mars, Akihisa Takahashi;Hiroko Ikeda;Megumi Hada, 日本放射線影響学会第65回大会, 15 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, English, Osaka, Japan, Domestic conference
• Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Akihisa Takahashi;Hiroko Ikeda;Nagy Lotfy Guiriuis;Yukari Yoshida;Fady;Megumi Hada, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference
• Increases chromosome aberrations in human cells exposed to simulated microgravity and radiation simultaneously, M. Hada;H. Ikeda;J-H. Mao;P.B. Saganti;A. Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference
• Expression profile of cell cycle or aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Hiroko Ikeda;Megumi Hada;Akihisa Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference
• Evaluation of cancer risk in space simulated environment using APCMin / + mice, Kenshi Suzuki;Chizuru Tsuruoka;Takamitsu Morioka;Akihisa Takahashi;Shizuko Kakinuma, 44th COSPAR Scientific Assembly, 19 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English, Athens, Greece, International conference
• ラット肝臓における放射線照射後の代償性反応の解明 -肝肥大の術前応用に向けて-, 安達 拓也;吉田 由香里;八高 知子;渋谷 圭;浦岡 俊夫;髙橋 昭久, 第59回日本放射線腫瘍学会生物部会学術大会・第50回放射線による制癌シンポジウム, 24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese, Japan, Domestic conference
• 肝正常組織における炭素イオン線分割照射の生物学的考察のための基礎的検討, 吉田 由香里;安達 拓也;Shenke Zhang;須田 裕夢;髙橋 昭久, 第59回日本放射線腫瘍学会生物部会学術大会・第50回放射線による制癌シンポジウム, 24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese, Japan, Domestic conference
• Invitation to “space medicine”, Akihisa Takahashi, The 123rd scientific meeting of the Japan Society of Medical Physics (JSMP), 16 Apr. 2022, 14 Apr. 2022, 18 Apr. 2022, Japanese, Yokohama, Japan, Domestic conference
• My future dream through "Living in Space", Akihisa Takahashi, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, Japanese, Online, Japan, Domestic conference
• Development of the Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Guirguis FNL;Yamanouchi S;Takeuchi K;Takahashi S;Tashiro M;Hidema J;Higashitani A;Adachi T;Zhang S;Yoshida Y;Nagamatsu A;Hada M;Takeuchi K;Takahashi T;Sekitomi Y;Takahashi A, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, English, Online, Japan, Domestic conference
• Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector: Adaptation to Microgravity and Changes in Cell Motility., Zhenlin Ju;Yi-Jen Chiu;Tamlyn N. Thomas;Sakuya Yamanouchi;Yukari Yoshida;Jun-ichi Abe;Akihisa Takahashi;Jing Wang;Keigi Fujiwara;Megumi Hada, NASA HRP IWS meeting 2022, 10 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference
• SwiNG: Combined-environment simulator of Moon and Mars, A. Takahashi;S. Yamanouchi;K. Takeuchi;S. Takahashi;M. Tashiro. Hidema;A. Higashitani;T. Adachi;S. Zhang;F.N.L. Guirguis;Y. Yoshida;A. Nagamatsu;M. Hada;K. Takeuchi;T. Takahashi;Y. Sekitomi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference
• Comprehensive gene expression analysis of human fibroblasts using 3D clinostat synchronized irradiation systems, Hiroko Ikeda;Megumi Hada;Alkihisa Takahashi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English, Houston, United States, International conference
• Combined effects of space radiation and variable gravity -2021 Annual Report-, TAKAHASHI Akihisa;SUZUKI Kenshi;TSURUOKA Chizuru;MORIOKA Takamistu;TAKESHIMA Tsuguhide;YOSHIDA Yukari;NAKAMURA Asako;IKEDA Hiroko;HADA Megumi;NAGAMATSU Aiko;OHIRA Yoshinobu;INATOMI Yuko;KAKINUMA Shizuko, 第36回 宇宙環境利用シンポジウム, 18 Jan. 2022, 18 Jan. 2022, 19 Jan. 2022, Japanese, Japan, Domestic conference
• Increased Chromosome Aberrations in Human Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada, Sakuya Yamanouchi, Jian Hua Mao, Hiroko Ikeda, Ianik Plante, Premkumar Saganti, Akihisa Takahashi, 2021 American Society for Gravitational and Space Research, 03 Nov. 2021, 03 Nov. 2021, 06 Nov. 2021, English, United States, International conference
• Biological effects of proton and carbon ions dual exposure in human fibroblasts, Hada M;Oizumi T;Nakamura A.J;Hirayama R;Takahashi A;Saganti P, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, English, International conference
• 冬眠による宇宙放射線防護効果, 髙橋 昭久, 日本宇宙生物科学会第35回大会, 24 Sep. 2021, 24 Sep. 2021, 26 Sep. 2021, Japanese, Domestic conference
• Recent findings on the relative biological effectiveness (RBE) for deterministic effects, Hiroshi YASUDA;Yukari YOSHIDA;Bing WANG;Kento NAGATA;Arifumi HASEGAWA;Akihisa TAKAHASHI, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, Japanese, Domestic conference
• Chromosome aberrations in human peripheral blood lymphocytes exposed simultaneously to radiation and simulated microgravity, Sakuya Yamanouchi;Takuya Adachi;Yukari Yoshida;Jordan Rhone;Jian-Hua Mao;Keigi Fujiwara;Premkumar B. Saganti;Akihisa Takahashi;Megumi Hada, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, English, Domestic conference
• The increases of chromosome aberration in human peripheral blood lymphocytes exposed to simulated microgravity and radiation simultaneously, Sakuya Yamanouchi, Takuya Adachi, Yukari Yoshida, Jordan Rhone, Jian-Hua Mao, Keigi Fujiwara, Premkumar B. Saganti, Akihisa Takahashi, Megumi Hada, 第68回北関東医学会総会, 30 Sep. 2021, English
• Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with a partial gravity environment, Shenke Zhang;Daishin Ueno;Takashi Ohira;Hisashi Kato;Tetsuya Izawa;Sakuya Yamanouchi;Yukari Yoshida;Akihisa Takahashi;Yoshinobu Ohira, 第68回北関東医学会総会, 30 Sep. 2021, English
• Synthetic hibernation and radioprotection, A. Puspitasari, M. Cerri, T. Hitrec, F. Squarcio, P. Simoniello, C. Totis, J. Oppermann, A. Takahashi, K. Hanamura, Y. Yoshida, T. Yakou, T. Shirao, M. Durante, W. Tinganelli, Italian Society for Radiation Research, 10 Sep. 2021, English, Italy, International conference
• Radiation protection effect of Synthetic hibernation following Carbon ion irradiation, Anggraeini Puspitasari, Fabio Squarcio, Matteo Cerri, Akihisa Takahashi, Kenji Hanamura, Yukari Yoshida, Tomoko Yakou, Tomoaki Shirao, Palma Simoniello, Cristina Totis, Julius Oppermann, Walter Tingan, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, 03 Oct. 2021, 06 Oct. 2021, English, Puerto Rico, International conference
• マウス悪性黒色腫に対するX線および炭素イオン線照射の局所制御効果とサイトカイン発現量との関連, 吉田由香里，脇畑庄人，石川仁，高橋昭久，櫻井英幸, 第58回生物部会学術大会, 04 Jun. 2021, Japanese, Domestic conference
• Research on Combined Effects of Space Radiation and Variable Gravity – 2020 Annual Report-, TAKAHASHI Akihisa;SUZUKI Kenshi;TSURUOKA Chizuru;MORIOKA Takamistu;TAKESHIMA Tsuguhide;YOSHIDA Yukari;NAKAMURA Asako;IKEDA Hiroko;HADA Megumi;NAGAMATSU Aiko;OHIRA Yoshinobu;INATOMI Yuko;KAKINUMA Shizu, 第 35 回 宇宙環境利用シンポジウム, 19 Jan. 2021, Japanese, Japan, Domestic conference
• 深宇宙，月，火星を模擬した装置開発, 髙橋昭久，山之内佐久也，竹内和臣，高橋祥吾，田代睦，日出間純，東谷篤志，安達拓也，Shenke Zhang，Fady Nagy Lotfy Guirguis，吉田由香里，永松愛子，秦恵，竹内邦人，高橋亨，関冨勇治, マイクログラビティ学会第32回大会, 07 Oct. 2020, Japanese, Japan, Domestic conference
• Recommendations for space radiation research, 髙橋昭久, 第13回Quantum Medicine研究会, 23 Feb. 2020, Japanese
• 宇宙放射線と重力環境変化による複合影響研究, 髙橋 昭久; 神戸 崚輔; 鈴木 健之; 鶴岡 千鶴; 森岡 孝満; 武島 嗣英; 吉田 由香里; 中村 麻子; 秦 恵; 永松 愛子; 大平 充宣; 稲富 裕光; 柿沼 志津子, 第34回宇宙環境利用シンポジウム, 21 Jan. 2020, Japanese
• RNA sequencing of cell cycle-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Takahashi A; Ikeda H; Muratani M; Hidema J; Fujiwara K; Souda H; Yoshida Y; Hada M, 2020 NASA Human Research Program Investigators' Workshop, 30 Jan. 2020, English
• Increased chromosome aberrations in lymphoblastoid cells exposed simultaneously to simulated microgravity and radiation, Yamanouchi S; Rhone J; Takahashi A; Hada M, 2020 NASA Human Research Program Investigators' Workshop, 30 Jan. 2020
• How to research about simulated space environments on the Earth, TAKAHASHI Akihisa, International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS2019), Kiryu, Japan, 04 Dec. 2019, English, International conference
• Assessment of Cancer Risk from Radiation Hazard in Space, TAKAHASHI Akihisa, The 3rd International Moon Village Workshop and Symposium, 05 Dec. 2019, English, International conference
• 宇宙生存環境拡大のために：宇宙放射線と重力環境変化の複合影響研究, 髙橋昭久, 京大定例オープンセミナー, 宇治, 30 Oct. 2019, Japanese, Domestic conference
• まだまだ終わらない宇宙実験, 髙橋 昭久, 日本放射線影響学会第62回大会市民公開講座, 京都, 16 Nov. 2019, Japanese, Domestic conference
• Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Jordan Rhone; Andrew J Beitman; Hiroko Ikeda; Ianik Plante; Hikaru Souda; Yukari Yoshida; Kathryn D Held; Keigi Fujiwara; Premkumar B Saganti; Akihisa Takahashi, ASGSR2019, 20 Nov. 2019, English, International conference
• Expression Profile of Cell Cycle-related Genes in Human Fibroblasts Exposed Simultaneously to Radiation and Simulated Microgravity, Akihisa Takahashi; Hiroko Ikeda; Masafumi Muratani; Jun Hidema; Megumi Hada; Keigi Fujiwara; Hikaru Souda; Yukari Yoshida, ASGSR2019, 21 Nov. 2019, English, International conference
• 「宇宙に生きる」ための宇宙放射線影響研究シナリオ, 髙橋 昭久, 日本宇宙生物科学会第33回大会, 22 Sep. 2019, Japanese, Domestic conference
• 放射線と疑似微小重力複合影響：ヒト線維芽細胞における遺伝子発現解析, 髙橋 昭久, 日本宇宙生物科学会第33回大会, 21 Sep. 2019, Japanese, Domestic conference
• 低酸素環境下における温熱感受性とDNA二本鎖切断生成, 吉田由香里; 富永信太朗; 高橋昭久, 日本ハイパーサーミア学会第36回大会, 川越, 06 Sep. 2019, Japanese, Domestic conference
• Is gravity parameter necessary for cancer risk assessment in long-term manned space missions?, Akihisa Takahashi, ISRBW2019, Dalian, China, 30 Sep. 2019, English, International conference
• Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-limb Unloading, Akihisa Takahashi; Shoto Wakihata; Liqiu Ma; Takuya Adachi; Yukari Yoshida; Yoshinobu Ohira, ISTS2019, Fukui, Japan, 19 Jun. 2019, English, International conference
• Space Experiments for "Cancer Progression" in the International Space Station, Akihisa Takahashi; Masafumi Muratani; Asako Sawano; Atushi Miyawaki, ISGP2019, Nagoya, Japan, 26 May 2019, English, International conference
• Future space experiments for “cancer risk assessment” in the ISS and the Gateway, TAKAHASHI Akihisa, SMME2019, Kiryu, Japan, 20 Mar. 2019, English, International conference
• Gunma University Heavy Ion Medical Center (GHMC): Therapy and Space Research, TAKAHASHI Akihisa, ICTSS2019, Kiryu, Japan, 08 May 2019, English, International conference
• 宇宙での微小重力環境におけるガンの進行, 髙橋昭久, 第33回宇宙環境利用シンポジウム, 24 Jan. 2019, Japanese, Domestic conference
• 宇宙放射線研究におけるGatewayへの期待, 髙橋昭久; 日出間純; 保田浩志, 国際宇宙探査ワークショップ, 01 Mar. 2019, Japanese, Domestic conference
• The synergistic effect of simulated microgravity and charged particle radiation on gene expression in human fibroblasts., Ikeda H; Muratani M; Puspitasari A; Held KD; Hidema J; Yoshida Y; Takahashi A, 42nd COSPAR, Jul. 2018, English, International conference
• 微小重力環境は、植物の紫外線障害・修復・応答に影響を及ぼすのか？, 日出間純; 髙橋昭久, 日本植物学会第82回大会, 15 Sep. 2018, Japanese, Domestic conference
• Combined effects of microgravity and UVB radiation on plant, Hidema J; Takahashi A, 第56回日本生物物理学会年会, 16 Sep. 2018, Japanese, Domestic conference
• 宇宙放射線研究のための今後の展望, 高橋 昭久, 日本宇宙生物科学会第32回大会, 23 Sep. 2018, Japanese, Domestic conference
• 植物における宇宙での微小重力と模擬太陽光の複合影響研究, 日出間純; 髙橋昭久, 第33回宇宙環境利用シンポジウム, 25 Jan. 2019, Japanese, Domestic conference
• Increased chromosome aberrations in cells exposed simultaneously to simulated microgravity and radiation., Rhone JR; Beitman A; Ikeda H; Souda H; Yoshida Y; Held KD; Fujiwara K; Takahashi A; Saganti PB; Hada M, 2019 NASA Human Research Program Investigators' Workshop, Jan. 2019, English, International conference
• X-ray irradiation induces disruption of the blood brain barrier with localized changes in claudin-5 and activation of microglia in the mouse brain, 第8回国際放射線神経生物科学会, 2018
• 重粒子線による正常組織障害の予測計算法の評価, 第55回群馬放射線腫瘍研究会, 2018
• New p53-targeted gene or chemical chaperone therapy in radiation and hyperthermic oncologies., Eur Symp Hyperthermic Oncol., 2002
• New p53-targeted therapy combined with gene or chemical chaperone therapy with radiation and hyperthernic cancer therapies., 1st Congr Egypt Soci Hyperthermic Therapy., 2002
• New hyperthermic therapies based on p53 gene status., 26th Congr Int Clin Hyperthermia Soc., 2004
• New hyperthermic therapy based on p53 gene status., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• (The young investigator Award of JSHO) Dynamics of DNA damage-recognizing proteins at heat-induced foci., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Accumulation of wild-type p53 is induced by heat treatment in a heat resistant human cancer cell line., 10th Radiat Biol Center Int Symp,, 1993
• Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation., 11th Int Congr Radiat Res., 1999
• New strategy of hyperthermic therapy combined to gene therapy or chemical chaperone therapy., 8th Int Congr Hyperthermic Oncol., 2000
• p53 status-based cancer therapy., Jpn-China Radiat Oncol Symp Kyoto., 2001
• DNA-PK activity plays an important role in radioadaptation by pre-irradiation with low-dose or low-dose rate in mouse spleen., Int Symp Radiat Health., 2001
• DNA-PK activity depressed radioadaptation of apoptosis induced by pre-irradiation at low-dose or low-dose rate in mouse spleen., Int Symp Radiat Homeostasis., 2001
• Restoration of mp53 to wtp53 by chemical chaperones brought p53-dependent apoptosis after radiotherapy., 12th Int Congr Radiat Res., 2003
• Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation., 1st Radiat Protect Asia-Oceania., 2002
• Radiation-induced apoptosis in Scid mouse spleen after a low-dose irradiation., 34th COSPAR., 2002
• New p53-targeted therapy combined with gene or chemical chaperone therapy., 19th Radiat Biol Cent Int Symp., 2002
• Analysis of cellular response by exposure to acute or chronic radiation in human lymphoblastoid TK-6 cells., 35th COSPAR., 2004
• The p53 gene status and new p53-targeted therapies of chemical chaperones and high LET radiations for cancer., BAERI Symp., 2005
• Radiation-induced p53-dependent and -independent apoptosis., 1st Asian Congr Radiat Res., 2005
• Development of thermotolerance requires interaction between polymerase β and heat shock proteins., 12th Biennial Natl Conf Indian Associat Hyperthermia Oncol Med., 2008
• Radioadaptive response by pre-irradiation at a low dose-rate., World Congr Nncl Med Biol., 2006
• Analysis of mutations of the rpsL gene in E. coli, B. subtilis and S. cerevisiae following long-term space flight on Mir., COSPAR Coll Mutag Cons Space Environ., 2006
• The biological function of radiation-induced nitric oxide radicals through Hdm2-p53 interaction., 13th Int Congr Radiat Res., 2007
• Heat-induced DNA damage and signal transduction., 4th Int Congr Stress Resp Biol Med., 2009
• Molecular chaperone therapy against human cancer cells., 4th Int Congr Stress Resp Biol Med., 2009
• Cell growth, morphology and cell differentiation of Dictyostelium in space environment., Int Workshop Ultra-long-term Cryogenic Preserv Network Biol Environ Specimens., 1997
• Gene expression of p53-regulated genes in mammalian cultured cells after exposure to space environment., 18th Ann NASA Space Radiat Invest Workshop., 2007
• Possibility of synergism on biological effects of space radiations under microgravity environment., 1st Asian Congr Radiat Res., 2005
• NHEJ pathway and low dose-rate effects (LDRE)., 1st Asian Congr Radiat Res., 2005
• Radioadaptive response by pre-irradiation at a low dose-rate., 5th Jpn-France Workshop Radiobiol Med Imaging., 2004
• Aim, preparation and fight in Rad Gene/LOH space experiments., 5th NIRS Int Open Lab Workshop., 2010
• Reports of “Rad Gene”-space radiation effects on human cells-., 5th NIRS Int Open Lab Workshop., 2010
• Gene expression analysis from human cultured cells frown in space., 5th NIRS Int Open Lab Workshop., 2010
• Induction of wild p53 following γ-irradiation, ultraviolet ray exposure and hyperthermia in a human glioblastoma cell line A-7., 42nd Ann Meeting Radiat Res Society & 14th Ann Meeting North Am Hyperthermic Soci., 1994
• p53-independent accumulation of WAF1 gene expression by heat., 10th Int Congr Radiat Res., 1995
• Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermo sensitivity and stimulates apoptosis by heat stress., 7th Int Congr Hyperthermic Oncol., 1996
• Hyperthermic enhancement of tumor growth inhibition by accelerated carbon-ion in transplantable human esophageal cancer., NIRS Int Sem Heavy Charged Particle Therapy Cancer., 1997
• CDDP induces p53-dependent apoptosis in tangue cancer cells., 1st World Congr Head Neck Oncol., 1998
• Induction of p53-dependent signal transduction by low dose radiations and space environment in rats., 49th Int Astronaut Congr., 1998
• Mutation induction in the rpsL gene on an E. coli-B. subtillis shuttle vector by space flight on MIR., 49th Int Astronaut Congr., 1998
• Accumulation of a tumor suppressor p53 in rat muscle after a space flight., 32nd COSPAR., 1998
• Accumulation of tumor suppressor p53 in rat muscle after space flight., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998
• Cell growth, cell differentiation and morphology of Dictyostelium discoideum in space environment., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998
• Tumor suppressor p53 response by low-dose-rate and chronic radiation., Natl Instit Radiol Sci Int Workshop., 1998
• Accumulation of a tumor suppression p53 in rat muscle after a space flight., Ann Invest Workshop Space Radiat Res., 1998
• Mutation induction by Mir flight in a bacterial rpsL shuttle vector., Ann Invest Workshop Space Radiat Res., 1998
• Mutant p53 gene transfection enhanced radiation-induced radioresistance and G2 arrest in human cancer cells., 11th Int Congr Radiat Res., 1999
• Detection of DNA damage induced by space radiation in the MIR-station and space shuttle by post-labeling of DNA., 10th Ann Space Radiat Health Investigat Workshop., 1999
• New strategy of cancer therapy: Restoration of mutant p53 to normal p53 function by glycerol as a chemical chaperone., 11th Int Congr Radiat Res., 1999
• Alkylating agent (MNU)-induced mutation in space environment., 33rd COSPAR., 2000
• Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture., 11th Int Conf Photobiol., 1992
• Detection of DNA damage induced by space radiations at Mir-space station and space shuttle by post-labeling of DNA., 11th Int Congr Radiat Res., 1999
• Low-dose-rate radiation attenuates tumor suppressor p53 response., 11th Int Congr Radiat Res Sat Meeting Biol Effects Low Dose Radiat., 1999
• The effects of microgravity on ligase activity in DNA repair for double strand breaks., 10th Ann Space Radiat Health Investigat Workshop., 1999
• Relationship between p53 status and amounts of hsp72 induction in human cancer cells., 60th Ann Meeting Soci Invest Dermatol., 1999
• Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone., Int Forum Hyperthermia Osaka., 1999
• Differentiation of Dictyostelium discoideum vegetative cells into spores during earth orbit in space., 33rd COSPAR., 2000
• The effects of microgravity on induced mutation in E. coli and S. cerevisiae cells., 33rd COSPAR., 2000
• Low-dose and low dose rate radiation attenuates apoptosis through tumor suppressor p53 response., 1st Int Workshop Space Radiat., 2000
• Tumor suppressor p53 response is blunted by low-dose-rate radiation., 10th Int Congr Int Radiat Protect Associat., 2000
• Suppression of p53 and Bax accumulation after X-irradiation by small dose pre-irradiation in radioadaptive survival response of C57BL/6 mice., 10th Int Congr Int Radiat Protect Associat., 2000
• Enzymatic chemical reaction under microgravity environment in space., Ann Int Gravitat Physiol Meeting., 2000
• Unique postural control of upside-down swimming catfish, Synodontis nigriventris, not affected by the change of gravity., Ann Int Gravitat Physiol Meeting., 2000
• The effect of microgravity on induced mutation through DNA synthesis during space flight., 22nd Int Symp Space Technol Sci., 2000
• DNA-PK activity acts radioadaptation of apoptosis induced by pre-irradiation at a low-dose in mouse spleen., 52nd Int Astronaut Congr., 2001
• Radiation-induced apoptosis in SCID mouse spleen after low-dose or low-dose rate irradiation., 2nd Int Coff Eff Low Very Low Doses Ionizing Radiat Human Health Word Council Nuclear Workers., 2001
• Radiation-induced apoptosis in Scid mouse spleen after low-dose or low-dose rate irradiation., 12th Ann Space Radiat Health Investigat Workshop., 2001
• Suppression of X-ray-induced apoptosis by low dose pre-irradiation in the spleen of C57BL/6 mice., Int Symp Radiat Homeostasis., 2001
• Effect of pre-irradiation with X-ray to mice whole body on radiation-induced killing, induction of splenic lymphocyte apoptosis and gene expression of mutated in Ca2+ channel α1A subunit., Int Symp Radiat Homeostasis., 2001
• New strategy of hyperthermic therapy: Combination with gene or molecular chaperone therapy., Godon Conf Radiat Therapy Cancer., 2001
• Pre-irradiation with a low dose-rate depressed radiation-induced TcR gene mutation., Int Symp Biol Effects Low Dose Radiat., 2002
• Enhanced radiation-induced fatal sensitivity and splenic lymphocyte apoptosis in mice with mutation in P/Q-type Ca2+ channel α1A subunit gene., Int Symp Biol Effects Low Dose Radiat., 2002
• Analysis of radiosensitivity in human squamous cell carcinoma cells with different p53 genetic status using cDNA microarray., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002
• Glycerol enhances CDDP-induced growth inhibition of mutant p53 tumors., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002
• Radiation biology in space: DNA damage and biological effects of space radiation., 1st Asia Congr Photobiol., 2002
• Effects of an HSP inhibitor, KNK437, on heat sensitivity and heat tolerance., 3rd Asia Congr Hypthermic Oncol., 2002
• p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET., 3rd Asia Congr Hypthermic Oncol., 2002
• Detection of DNA damage induced by space radiation in Mir and Space Shuttle., 2nd Int Workshop Space Radiat Res., 2002
• Pre-irradiation at a low-dose-rate blunted tumor suppressor p53 response., 2nd Int Workshop Space Radiat Res., 2002
• The effect of microgravity on induced mutation through DNA synthesis during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Radiation microbiology in space environment conducted using space shuttle and space station Mir., 2nd Int Workshop Space Radiat Res., 2002
• Radiation responses of survival and splenic lymphocyte apoptosis in rolling mouse Nagoya following low-dose pre-irradiation., 2nd Int Workshop Space Radiat Res., 2002
• Radiation-induced gene expression about apoptosis-related genes by DNA array analysis., 2nd Int Workshop Space Radiat Res., 2002
• The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae during space flight., 2nd Int Workshop Space Radiat Res., 2002
• The effects of microgravity on ligase activity in DNA repair of double-strand breaks during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Differentiation of Dictyostelium discoideum during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Pre-irradiation at a low dose-rate blunted p53 response., 12th Int Congr Radiat Res., 2003
• Repair system for DNA damages in meiotic cells of Caenorhabditis elegans., 2nd Int Workshop Space Radiat Res., 2002
• Mutation frequency of plasmid DNA and Escherichia coli by long-term space flight on Mir., 2nd Int Workshop Space Radiat Res., 2002
• Sensitization by glycerol for CDDP-therapy against mutant p53 tumors., 7th Japan-Taiwan Conf Otolaryngol Head Neck Surg., 2003
• New p53-targeted cancer therapies combined with chemical or molecular chaperone., 1st Int Congr Stress Resp Biol Med., 2003
• Gene expression after X-irradiation and/or glycerol in human anaplastic carcinoma cells harboring mutated p53 gene., 12th Int Congr Radiat Res., 2003
• Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene., 12th Int Congr Radiat Res., 2003
• The mechanism of radiation adaptive response., Conf Recent Trend Radiat Biol., 2004
• Glycerol restores radio-sensitivity of transplanted mp53 tumors., 6th Int Conf Head Neck Cancer., 2004
• Expression of gene and protein after CDDP and/or glycerol treatment of mutated p53 cells., 6th Int Conf Head Neck Cancer., 2004
• Dorsal light reflex is absent in the postural control system of the upside-down swimming catfish, Synodontis nigriventris., 35th COSPAR., 2004
• Heat sensitization by inhibitors targeted for signaling factors of cellular survival., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• Evidence for DSBs as a critical trigger of heat-induced cell killing., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• High-LET radiation enhanced p53-independent apoptosis., 3rd Int Workshop Space Radiat., 2004
• Effects of mild hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, referring to the effect on intratumor quiescent cells., 9th Int Congr Hyperthermic Oncol., 2004
• DSB is the targets of cell killing induced by heat., 9th Int Congr Hyperthermic Oncol., 2004
• Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53., 9th Int Congr Hyperthermic Oncol., 2004
• Mediation of NBS1 to radiation-induced cellular survival signaling pathway via NF-κB., 1st Asian Congr Radiat Res., 2005
• p53-independent enhancement of radiation sensitivity by siRNA targeted for NBS1 in human tongue cancer cells., 1st Asian Congr Radiat Res., 2005
• Heat sensitizers-targeted for anti-apoptosis signal transduction pathways in human cultured cancer cells., 9th Int Congr Hyperthermic Oncol., 2004
• Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 1st Asian Congr Radiat Res., 2005
• Heat sensitization by PD98059, an inhibitor targeted for MAPK cascade., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Heat sensitization by targeting heat-induced cell survival signal transduction through Akt., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Dynamics of DNA damage-recognizing proteins at heavy-ion-induced track., 4th Int Workshop Space Radiat Res., 2006
• Apoptosis-related protein expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53 with protein microarray., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• The role of polymerase β and HSPs on the thermo-tolerance., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Radioadaptive response by low or high LET-radiation., 36th COSPAR., 2006
• Analysis of matrix proteins of otolith in upside-down catfish., 36th COSPAR., 2006
• Phosphorylation of DNA damage-recognizing proteins at heavy-ion track., 36th COSPAR., 2006
• Review: Interaction of microgravity and space radiations., 27th Ann Int Gravit Phys Meeting., 2006
• p53-independent heat sensitization of lung cancer cells by PD98059, an inhibitor targeting for MAPK cascade., 12th Congr Asian Pacific Soc Respirol., 2007
• siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner., 13th Int Congr Radiat Res., 2007
• Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 13th Int Congr Radiat Res., 2007
• Spatio-temporal responses to different UV wavelengths in human skin organ culture., 13th Int Congr Radiat Res., 2007
• High-LET radiations enhanced apoptosis regardless of p53 status., 13th Int Congr Radiat Res., 2007
• Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks., 13th Int Congr Radiat Res., 2007
• Preparation for ISS experiment; biological influences of space radiation and microgravity., 15th Int Acad Astron., 2007
• Heat-induced DNA strand breaks and their repair., 8th ICHS Annual-Convention & 4th Biennel Natl Meet Int Associat Hyperthermic Oncol Med., 2007
• The p53-dependent radioadaptive response., 37th COSPAR., 2008
• Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with ？H2AX in the nucleus after heat treatment., Ataxia-Telangiectasia Workshop 2008., 2008
• Hdm2 and NO radicals contribute to the p53-dependent radioadaptive response., Ataxia-Telangiectasia Workshop 2008., 2008
• The study of target genes deciding heat-sensitivity., 10th Int Congr Hyperthermic Oncol., 2008
• Development of thermotolerance requires interaction between polymerase β and heat shock protein., 10th Int Congr Hyperthermic Oncol., 2008
• Tween80 enhances heat-induced arrest of cell proliferation through regulating Akt and NBS1 signaling pathways., 10th Int Congr Hyperthermic Oncol., 2008
• A low dose pre-irradiation induces radio- and heat- resistance via HDM2 and NO radicals, and is associated with p53 functioning., Int Conf Radiat Damage Biomol Systems., 2009
• DNA-DSB recognition proteins localize along heavy-ion induced tracks in the cell nucleus., Heavy Ions Ther Space Symp., 2009
• The molecular mechanism of p53-dependent radioadaptive response by NO radicals., Heavy Ions Ther Space Symp., 2009
• The molecular mechanism of radioadaptive response., 2nd Asian Congr Radiat Res., 2009
• Cell death induced by high LET and low LET radiations., 2nd Asian Congr Radiat Res., 2009
• NO radicals choreograph p53-different radio-sensitivity in human lung cancer cells., 2nd Asian Congr Radiat Res., 2009
• Protein microarray analysis of apoptosis-related protein expression following heat shock in human toungue squamous cell carcinomas containing different p53 phenotypes., 2nd Asian Congr Radiat Res., 2009
• The therapeutic target of DNA repair pathways against alkylating agents., 2nd Asian Congr Radiat Res., 2009
• Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity in lung cancer cells bearing different p53 gene status., 2nd Asian Congr Radiat Res., 2009
• Formaldehyde-induced DNA damage and its repair., 2nd Asian Congr Radiat Res., 2009
• Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells., 2nd Asian Congr Radiat Res., 2009
• Space experiment “Rad Gene”-report 1; p53-Dependent gene expression in human cultured cells exposed to space environment., 38th COSPAR., 2010
• (国際癌治療増感研究協会協会賞受賞講演) がん細胞の温熱耐性獲得を抑制するしくみの解明., 第15回国際癌治療増感研究会., 2009
• (特別企画ICHO2008から見た世界のハイパーサーミアの現状と将来) 生物学・基礎医学の立場から～温熱によるDNA損傷について～., 日本ハイパーサーミア学会第25回大会., 2008
• Space experiment “Rad Gene”-report; Detection of DNA damage and adaptive response activity of human cells exposed to space radiations., 38th COSPAR., 2010
• 温熱による細胞死の分子機構., 第12回関西ハイパーサーミア研究会., 2010
• (日本ハイパーサーミア学会阿部賞受賞講演) 温熱誘導細胞死の基礎的研究., 日本ハイパーサーミア学会第26回大会., 2009
• (日本ハイパーサーミア学会一般研究助成申請課題報告) 温熱と放射線併用療法における基礎的研究-治療効果とp53遺伝子型の相関性., 日本ハイパーサーミア学会第20回大会., 2003
• (日本放射線影響学会奨励賞受賞講演) あらかじめの放射線被曝経験による放射線誘導アポトーシスの軽減., 日本放射線影響学会第44回大会., 2001
• (日本宇宙生物科学会奨励賞受賞講演) 宇宙環境における細胞性粘菌Dictyostelium discoideumの分化と突然変異., 日本宇宙生物科学会第12回大会., 1998
• 宇宙空間における細胞性粘菌の分化・形態形成., 第14回宇宙利用シンポジウム., 1997
• MIR放射線生物影響実験: ヒト細胞、大腸菌及びDNAへの影響., 日本宇宙生物科学会第12回大会., 1998
• MIR放射線生物影響実験: 枯草菌胞子におけるrpsL変異誘発., 日本宇宙生物科学会第12回大会., 1998
• MIR放射線生物影響実験: 酵母菌におけるrpsL変異誘発., 日本宇宙生物科学会第12回大会., 1998
• 変異型p53に対するグリセロールの分子シャペロン様作用., 第37回日本医学放射線学会生物部会学術大会., 1998
• p53遺伝子型のみ異なる神経膠芽腫細のγ線感受性., 第37回日本医学放射線学会生物部会学術大会., 1998
• 変異型p53遺伝子導入ヒト舌癌移植系における温熱感受性とアポトーシス誘導の検討., 日本ハイパーサーミア学会第17回大会., 2000
• 遺伝子治療･化学シャペロン治療による新しい癌治療の基礎的研究., 日本放射線影響学会第44回大会., 2001
• DNAマイクロアレイを用いた放射線誘導アポトーシスの遺伝子解析., 第31回日本医学放射線学会生物部会放射線による制癌シンポジウム., 2001
• サカサナマズの耳石器官について., 第17回宇宙利用シンポジウム., 2001
• 宇宙放射線によるp53を中心としたシグナルトランスダクション誘導とその生物学的意義., 日本宇宙生物科学会第14回大会., 2002
• 低線量･低線量率放射線による生物影響研究., 日本宇宙生物科学会第16回大会., 2002
• 放射線生物学の駆使によるブレイクスルー., 日本放射線影響学会第46回大会., 2003
• 低線量･低線量率事前照射による放射線感受性の低減., 日本放射線影響学会第46回大会., 2003
• 放射線誘導シグナル伝達因子を標的とした放射線癌治療の基礎的研究., 日本放射線影響学会第47回大会., 2004
• 太陽放射光に対する生体が持つ光回復能力の限度., 日本宇宙生物科学会第18回大会., 2004
• ヒト癌細胞および正常細胞の温熱感受性に及ぼすNBS1標的siRNAの影響., 日本ハイパーサーミア学会第21回大会., 2004
• 温熱誘導細胞死のトリガーとしてのDNA二本鎖切断に関する証拠., 日本ハイパーサーミア学会第21回大会., 2004
• 高エネルギー宇宙粒子線による生物影響研究., 第20回宇宙利用シンポジウム., 2004
• 低線量重粒子線による放射線適応応答., 日本宇宙生物科学会第19回大会., 2005
• あらかじめの低線量率放射線照射が温熱誘導アポトーシスを抑制する., 日本ハイパーサーミア学会第22回大会., 2005
• p53遺伝子型からみたHSP合成阻害剤による温熱/放射線増感., 日本ハイパーサーミア学会第22回大会., 2005
• NBS1を標的としたsiRNAによる放射線増感., 第35回放射線による制癌シンポジウム., 2005
• 宇宙放射線研究の再構築とその展望., 第22回宇宙利用シンポジウム., 2006
• 宇宙放射線研究の再構築とその展望., 日本放射線影響学会第50回大会., 2007
• DNA損傷認識および修復機構を中心としたがん温熱療法における標的遺伝子の探索., 日本ハイパーサーミア学会第24回大会., 2007
• Tween80と温熱併用処理によるがん細胞増殖停止へのNBS1の関与., 日本ハイパーサーミア学会第24回大会., 2007
• 国際宇宙ステーションにおける曝露部施設を用いた太陽紫外線の生物影響実験の重要性., 第23回宇宙利用シンポジウム., 2007
• 本年度実施予定のISSにおける宇宙放射線研究., 日本宇宙生物科学会第22回大会., 2008
• 宇宙ステーションにおける宇宙放射線の生物影響研究., 第24回宇宙利用シンポジウム., 2008
• あらかじめの温熱環境曝露はマウス水浸拘束誘発胃潰瘍を抑制する., 日本ハイパーサーミア学会第26回大会., 2009
• 刺激のクロストーク；あらかじめの温熱や放射線刺激は放射線抵抗性や温熱耐性をもたらす., 日本ハイパーサーミア学会第26回大会., 2009
• 宇宙ステーションにおける宇宙放射線の生物影響研究-2-., 第25回宇宙利用シンポジウム., 2009
• The role of a tumor suppressor gene product, p53, in space environment., 日本マイクログラビティ応用学会第24回学術講演会., 2009
• Influences of space environments (radiation and microgravity) on human cultured cells: An approach from mutation (LOH) analyses., 日本マイクログラビティ応用学会第24回学術講演会., 2009
• ISS-Rad Gene/LOH report; Purpose, preparation and flight experiments of Rad Gene and LOH., 日本宇宙生物科学会第23回大会., 2009
• ISS-Rad Gene report 1: p53-dependent gene expression in human cultured cells exposed to space environment., 日本宇宙生物科学会第23回大会., 2009
• ISS-Rad Gene report 2: Detection of space radiation-induced DNA damage in cell nuclei by γH2AX positive foci staining., 日本宇宙生物科学会第23回大会., 2009
• ISS-Rad Gene report 3; Adaptive response activity of human cells exposed to space radiations., 日本宇宙生物科学会第23回大会., 2009
• A biological experiment in “Kibo”: An approach to elucidate biological influences of space environments by analysis of mutations (LOHs) in human cultured cells., 日本宇宙生物科学会第23回大会., 2009
• 「きぼう」での宇宙実験Rad Gene報告1: 宇宙環境に曝露されたヒト培養系におけるp53依存性遺伝子およびタンパク質発現., 日本放射線影響学会第53回大会., 2009
• 低LETと高LET放射線によるDNA二本鎖切断修復欠損細胞の感受性, 第40回日本放射線技術学会秋季学術大会, 2012
• 肺癌細胞における炭素線照射とカルボプラチン、パクリタキセルの併用効果, 日本放射線腫瘍学会第25回学術大会, 2012
• Cell lethality by carbon- Ion beams in X-ray resistant cells., 51st Ann Meeting of Particle Therapy Co-operative Group, 2012
• Fanconi anemia修復経路を分子標的とした脳腫瘍アルキル化剤の増感効果の検討, 第18回国際癌治療増感研究会, 2012
• 放射線抵抗性細胞における温熱感受性についての検討., 第18回癌治療増感研究会, 2012
• 粒子線治療における生物学の役割., 第41回放射線による制癌シンポジウム, 2012
• ヒトグリオブラストーマA172 細胞の遊走及び浸潤に対するp53 突然変異の効果., 第41回放射線による制癌シンポジウム, 2012
• Expression of genes and proteins in human cultured lymphoblastoid cells during spaceflight., 39th COSPAR, 2012
• Recent advances in the biology of carbon-ion cancer therapy, KHIMA Seminar on Heavy-ion Radiotherapy, 2012
• X線抵抗性細胞の重粒子線感受性., 伊香保BSの会・第2回多分野交流会, 2012
• A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status., 11th Int Congr Hyperthermic Oncol., 2012
• Heat treatment as well as X-ray-irradiation depresses gastric mucosal damage induced with restraint plus water-immersion stress through HSP-induction in mice., 11th Int Congr Hyperthermic Oncol., 2012
• ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating., 11th Int Congr Hyperthermic Oncol., 2012
• Hyperthermic sensitization efficacy as a target of homologous recombination repair pathways in the oral cancer cells., 11th Int Congr Hyperthermic Oncol., 2012
• 宇宙放射線のバイオロジカルドシメトリー., 日本放射線影響学会第55回大会, 2012
• 放射線誘発バイスタンダー応答による放射線適応応答の誘導., 日本放射線影響学会第55回大会, 2012
• X線抵抗性細胞における炭素イオン線の感受性., 第71回日本癌学会学術総会, 2012
• 船外実験プラットフォーム利用実験施設., 第26回日本宇宙生物科学会学術集会, 2012
• X線耐性獲得細胞における重粒子線感受性, 第2回国際放射線神経生物学会大会, 2011
• The role of the DNA DSB repair on cell killing by heavy-ion beams., 「重粒子線医学工学グローバルリーダー養成プログラム」公開シンポジウム, 2012
• ヒト肺がん細胞の炭素線治療における標的としてのNHEJ修復., 第15回癌治療増感研究シンポジウム, 2013
• ヒト肺がん細胞におけるNHEJ修復およびG2チェックポイント阻害剤の炭素線増感効果., 第3回国際放射線神経生物学会大会, 2013
• DNA二本鎖切断修復を分子標的としたLET依存的な殺細胞効果., 第3回国際放射線神経生物学会大会, 2013
• 神経膠芽腫細胞に対する炭素線とtemozolomide併用に関する生物学的効果の検討., 第3回国際放射線神経生物学会大会, 2013
• がん幹細胞様細胞に対する重粒子線の生物学的効果, 第48回群馬放射線腫瘍研究会, 2013
• 放射線抵抗性がん幹細胞様細胞に対する温熱感受性., 第17回関東ハイパーサーミア研究会／全身ハイパーサーミア研究会合同学術研究会, 2013
• LET依存的な殺細胞効果におよぼすDNA二本鎖切断修復の役割., 第6回 Quantum Medicine 研究会, 2013
• DNA二本鎖切断修復による放射線感受性のLET依存性., 第47回群馬放射線腫瘍研究会, 2012
• 肺がん細胞における炭素線照射とDNA修復および細胞周期調節阻害剤の併用効果., 第47回群馬放射線腫瘍研究会, 2012
• FANCD1のノックダウンは脳腫瘍アルキル化剤によって誘導される相同組換えのRad51活性を低減させる, 17回 癌治療増感研究会, 2011
• Space experiment of “Rad Gene” in ISS Kibo: Radiation effects in human cultured cells., 3rd Asian Congress of Radiation Research (ACRR2013)., 2013
• LET-dependent biological effect of DNA DSB repair on cell killing., Ion Therapy and Space Radiation Symposium 2013 (HITSRS2013)., 2013
• LET-dependent biological effect of DNA double-strand break repair on radiosensitivity., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013
• Combination effect of carbon-ion beams and DNA repair inhibitor and/or cell cycle regulation inhibitor on cell killing in lung cancer cells., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013
• Depression of p53-independent Akt survival signals in human oral cancer cells after exposure to high-LET radiation., Asian Congress of Radiation Research (ACRR2013)., 2013
• 放射線抵抗性がん幹細胞様細胞における温熱感受性., 日本ハイパーサーミア学会第30回大会, 2013
• 口腔がん細胞に対する相同組換え修復を標的とした温熱増感効果., 日本ハイパーサーミア学会第30回大会, 2013
• 船外実験プラットフォーム利用実験施設 Exposure area at ISS platform., 第27回日本宇宙生物科学会学術集会, 2013
• LET依存的な標的増感候補としてのNHEJ修復およびHR修復., 第19回癌治療増感研究会, 2013
• ヒト膵臓癌細胞におけるPTK6によるX線誘導遊走・浸潤能の亢進., 第49回群馬放射線腫瘍研究会, 2013
• ヒト肺がん細胞の炭素線治療における標的増感候補としてのNHEJ修復および細胞周期調節., 第19回癌治療増感研究会, 2013
• 熱ストレスによる開始tRNAMetの細胞内動態., 第15回日本RNA学会年会, 2013
• 殺細胞効果におよぼすDNA二本鎖切断修復のLET依存性., 第51回日本放射線腫瘍学会生物部会学術大会, 2013
• 放射線感受性におよぼすDNA二本鎖切断修復のLET依存的な効果., 第72回日本癌学会学術総会, 2013
• 非小細胞肺癌に対する炭素線照射とカルボプラチン、パクリタキセル併用の基礎的検討., 第51回日本癌治療学会学術集会., 2013
• 宇宙で力を発揮する混合容器の開発, 第27回宇宙利用シンポジウム, 2011
• 2015年－2020年のISSでの宇宙実験装置開発―特にISS暴露部の必要性, 第27回宇宙利用シンポジウム, 2011
• 二本鎖切断修復を標的とした中性子捕捉療法の増感効果の検討, 第13回国際癌治療増感研究シンポジウム, 2011
• Achievement of the first life science experiments in the Japanese Experimental Module "Kibo" of the ISS, The 28th International Symposium on Space Technology and Science, 2011
• Long term stay against space radiation for human health, The 28th International Symposium on Space Technology and Science, 2011
• DNA修復を標的とした温熱増感研究, 17回 癌治療増感研究会, 2011
• FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ, ICRR 2011, 2011
• Space radiation effects on human cultured cells in an International Space Station at Kibo module, ICRR 2011, 2011
• 温熱感受性に対するDNA二本鎖切断修復の役割について, 日本ハイパーサーミア学会第28回大会, 2011
• 温熱によるtRNA分解促進に対する耐性獲得機構の解明, 日本ハイパーサーミア学会第28回大会, 2011
• 口腔癌細胞に対するBRCA2を標的とした温熱増感効果, 日本ハイパーサーミア学会第28回大会, 2011
• 「きぼう」利用シナリオと宇宙生命科学のとりくみ-放射線生物学の観点から-, 日本宇宙生物科学会第25回大会, 2011
• Irreparable damage for DNA ligase IV induced by BNCT, 第70回日本癌学会学術総会, 2011
• Target genes deciding heat sensitivity, 第70回日本癌学会学術総会, 2011
• BRCA2 as a new molecular target for 5-FU in human oral cancer cells, 第70回日本癌学会学術総会, 2011
• 神経膠芽腫細胞におけるX線誘導遊走能の分子機構, 日本放射線影響学会第54回大会, 2011
• X線抵抗性細胞の重粒子線感受性について, 日本放射線影響学会第54回大会, 2011
• 中性子補足療法によって誘導されるDNA ligase IVによって修復されないDNA損傷, 日本放射線影響学会第54回大会, 2011
• 神経膠芽腫細胞におけるX線照射により誘導された遊走能の分子機構の解明, 第2回国際放射線神経生物学会大会, 2011
• 重粒子線照射後における非小細胞肺癌の遊走能について, 第14回癌治療増感研究シンポジウム, 2012
• DNA修復経路を標的とした5-FU増感効果の検討, 第14回癌治療増感研究シンポジウム, 2012
• 温熱による相同組換え修復の誘導, 第20回関東ハイパーサーミア研究会・全身ハイパーサーミア研究会 合同学術研究会, 2016
• ハイパーサーミアの生物作用: 温熱誘導分子損傷., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol., 2014
• ヒト肺がん細胞の炭素線治療における標的としての細胞周期調節., 第16回癌治療増感研究シンポジウム, 2014
• ヒト肺がん細胞における細胞周期調節阻害剤MK-1775の炭素線増感効果., 第4回国際放射線神経生物学会大会., 2014
• ヒト膵臓癌細胞におけるLPAによるX線誘導遊走・浸潤能の亢進., 4回国際放射線神経生物学会大会, 2014
• 神経幹細胞と神経膠芽腫細胞の増殖率を指標とした放射線感受性, 第4回国際放射線神経生物学会大会., 2014
• 相同組換え修復関連Rad51阻害剤B02による温熱増感効果., 第18回関東ハイパーサーミア研究会全身ハイパーサーミア研究会 合同学術研究会., 2014
• ヒト膵臓癌細胞におけるLPA受容体を介した遊走・浸潤と放射線治療戦略, 第16回癌治療増感研究シンポジウム, 2014
• HR修復およびNHEJ修復阻害剤による炭素線増感効果の検討., 第20回癌治療増感研究会., 2014
• HR修復およびNHEJ修復阻害剤による温熱増感効果の検討, 第20回癌治療増感研究会., 2014
• DNA二本鎖切断修復阻害剤による炭素線増感効果の検討., 第52回日本放射線腫瘍学会生物部会学術大会., 2014
• ヒト膵癌細胞におけるLPA受容体を標的とした放射線増感効果の検討., 第52回日本放射線腫瘍学会生物部会学術大会., 2014
• 炭素線治療における放射線増感剤の標的候補としてのHRおよびNHEJ., 第16回癌治療増感研究シンポジウム, 2014
• 肺腺癌細胞におけるRhoシグナル経路を介した炭素線誘発遊走能増加とROCK阻害剤Y-27632の抑制作用について, 第52回日本癌治療学会学術集会, 2014
• Rad51阻害剤B02による温熱増感の可能性の検討, 第73回日本癌学会学術総会, 2014
• 神経幹細胞および神経膠芽腫細胞における増殖率を指標としたX線および炭素線の感受性, 日本放射線影響学会第57回大会., 2014
• NHEJ plays a more important role than HR in defining radiosensitivity after exposure to high-LET radiation, ICRR2015, 2015
• Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells, SRHIT2015, 2015
• 温熱の分子標的に関する考察, 日本ハイパーサーミア学会 第32回大会, 2015
• 宇宙放射線の生物影響研究, 市民公開シンポジウム放射線と人との係わり合い, 2015
• 船外実験プラットホーム(曝露部)実験施設利用を視野に入れた、太陽放射光の植物影響研究, 第30回 宇宙環境利用シンポジウム, 2016
• 3Dクリノスタット放射線同期照射システムの開発, 第30回 宇宙環境利用シンポジウム, 2016
• MacroH2A1/Lin28B/let-7 pathway as a target for radiosensitization in cancer cells, 第18回癌治療増感研究シンポジウム, 2016
• Radiosensitization effect of carbon ion irradiation with cell-cycle checkpoint inhibitors and/or DNA repair inhibitors on cell killing, 第18回癌治療増感研究シンポジウム, 2016
• 正常脳組織における放射線急性障害の微視的解析, 第6回国際放射線神経生物学会, 2016
• 放射線に対する微小重力環境の生物影響を解析するための装置開発, 第6回国際放射線神経生物学会, 2016
• DNA修復と細胞周期調節を分子標的とした重粒子線の増感効果, 第49回制癌剤適応研究会, 2016
• Enhancement of heat sensitivity of human cancer cells by HR inhibitor B02 but not NHEJ inhibitor NU7026., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol, 2014
• 重粒子線によるがん治療効果向上のための基礎研究., 第61回重粒子医科学センター研究交流会, 2014
• 放射線感受性におよぼすDNA二本鎖切断修復のLET依存性, 第8回高崎量子応用研究シンポジウム., 2013
• 放射線増感剤の標的候補としてのDNA二本鎖切断修復によるLET依存的感受性., 第4回国際放射線神経生物学会大会., 2014
• Research of biological effect by solar radiation using exposure area at ISS platform., 2014
• Enhancement of heat sensitivity by depression of homologous recombination repair., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol., 2014
• Increase in cell motility by C-ion irradiation and its inhibition by the ROCK inhibitor in lung adenocarcinoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53), 2014
• Combination effect of carbon-ion beams and cell cycle regulation inhibitor on cell killing in lung cancer cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014
• Relation between sensitivity to carbon-ion beams and expression of cancer stem cell marker in melanoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014
• ヒト膵癌細胞においてLPA1,3受容体アンタゴニストKi16425は放射線感受性を高めるか., 第20回癌治療増感研究会, 2014
• 重粒子線誘導性CRTによる遠隔腫瘍の生着拒絶および転移抑制, 第20回癌治療増感研究シンポジウム, 2018
• X-irradiation of developing neurons causes delayed decrease in cell number and in synaptic related proteins of surviving neurons, 第8回国際放射線神経生物科学会, 2018
• 重粒子線と樹状細胞併用療法の基礎研究, 第55回群馬放射線腫瘍研究会, 2018
• X線と重粒子線によるDNA二本鎖切断生成の酸素濃度依存性, 第55回群馬放射線腫瘍研究会, 2018
• Irradiation of immature neurons causes delayed decreases in the number of neurons and in the postsynaptic protein drebrin, 日本宇宙生物科学会第31回大会, 2017
• 宇宙滞在が骨格筋に及ぼす影響 ？ 重力負荷減少だけではなさそう?, 日本宇宙生物科学会第31回大会, 2017
• 放射線が正常脳に及ぼす影響についての研究, 日本宇宙生物科学会第31回大会, 2017
• ヴァン・アレン帯に挑む生命科学実験, 第32回宇宙環境利用シンポジウム, 2018
• 宇宙環境に対する植物反応解析のための模擬太陽光人工光源ユニットの開発, 第32回宇宙環境利用シンポジウム, 2018
• 航空機放物飛行実験による微小重力下での植物栽培システム水循環, 第32回宇宙環境利用シンポジウム, 2018
• Enhancement of heat sensitivity of human cancer cells by inhibitor of HR but not NHEJ, ICHO2016, 2016
• 炭素イオン線がん治療の分割照射における治療効果比の基礎的検討, 第54回日本放射線腫瘍学会生物部会学術大会, 2016
• 宇宙に生きる：宇宙放射線の生物影響研究, 第63回北関東医学会総会, 2016
• ヒト線維芽細胞における重粒子線と微小重力の複合影響による遺伝子発現解析, 第31回宇宙環境利用シンポジウム, 2017
• ISSでの植物の微小重力環境下での太陽粒子線影響評価研究, 第31回宇宙環境利用シンポジウム, 2017
• HR修復およびNHEJ修復阻害剤による炭素線増感効果の検討, 第1回QST高崎研シンポジウム, 2017
• 細胞生存パラメータのLET依存性とNHEJ修復との関係, 第1回QST高崎研シンポジウム, 2017
• 炭素線によるがん治療効果向上ための基礎研究成果~ DNA修復と細胞周期調節の阻害剤による炭素線の増感効果~, 第19回癌治療増感研究シンポジウム, 2017
• 重粒子線照射と免疫チェックポイント阻害剤（抗CTLA4抗体）併用による抗腫瘍増感効果, 第19回癌治療増感研究シンポジウム, 2017
• Comprehensive gene expression analysis of human fibroblast with combined exposure to microgravity and heavy-ions for simulating space conditions, 第7回国際放射線神経生物科学会, 2017
• Effects of oxygen concentration and radiation quality on radiation-induced DNA damage, 第7回国際放射線神経生物科学会, 2017
• Dependence of normal skin damage caused by Carbon ions on linear energy transfer, 第7回国際放射線神経生物科学会, 2017
• Host-dependent effects of metastasis suppression by Carbon-ion and dendritic cell combined therapy, 第7回国際放射線神経生物科学会, 2017
• Relation between LET dependency and NHEJ repair in cell survival parameter, 第7回国際放射線神経生物科学会, 2017
• Acute and chronic effects of low dose X-irradiation on immature hippocampal neurons in vitro, 第7回国際放射線神経生物科学会, 2017
• Development of new devices that analyze the combined effects of radiation and microgravity: 2nd report, 第7回国際放射線神経生物科学会, 2017
• 宇宙環境を模擬した疑似微小重力と重粒子線の複合影響解析, 第10回Quantum Medicine研究会, 2017
• 転写調節因子Id1はp53依存的に放射線誘発細胞老化を抑制する, 第23回癌治療増感研究会, 2017
• 重粒子線照射による生体抗腫瘍免疫応答の検討, 第23回癌治療増感研究会, 2017
• 正常脳組織における放射線急性障害の解析, 第55回日本放射線腫瘍学会生物部会学術大会, 2017
• Lin28強発現悪性黒色腫細胞におけるがん幹細胞形質と炭素線の感受性, 第55回日本放射線腫瘍学会生物部会学術大会, 2017
• Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells, PTCOG56, 2017
• Performance evaluation of new devices to synchronize X-ray or heavy-ion irradiation and simulated microgravity for space radiation research, ISTS2017, 2017
• New devices to synchronize irradiation and simulated microgravity for space radiation research, ISSRPRT, 2017
• 腫瘍内微小環境における温熱誘導DNA二本鎖切断, 日本ハイパーサーミア学会第34回大会, 2017
• Heat induces DNA double strand breaks under hypoxia, The 7th Asian Congress of Hyperthermic Oncology, 2018
• 低酸素環境下における重粒子線および温熱誘導DNA二本鎖切断の生成, 第24回癌治療増感研究会, 2018
• Anti-tumor and anti-metastasis effects of carbon-ion radiotherapy combined with anti-CTLA4 antibody, PTCOG57, 2018
• 低酸素環境下における温熱誘導DNA二本鎖切断の生成, 第22回関東ハイパーサーミア研究会・全身ハイパーサーミア研究会合同学術研究会, 2018
• 神経幹細胞および神経膠芽腫細胞における増殖率を指標としたX線および炭素線の感受性, 日本放射線影響学会第57回大会, 2014
• Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632., ICRR2015, 2015
• 重粒子線および温熱によるX線耐性の克服, 2014
• ヒト膵癌細胞におけるLPAを介した放射線誘導遊走・浸潤能の亢進, 第87回日本生化学大会, 2014
• ヒト膵癌細胞におけるLPA受容体を介した遊走・浸潤を標的とした放射線治療戦略, 2015
• Effect of DSB repair on cell killing by radiation with different LET values, 2015
• Targeting carbon-ion beams-induced G2 checkpoint activation with the Wee-1 inhibitor MK-1775 in lung cancer cells, 2015
• ヒト膵癌細胞におけるLPA受容体を介した遊走・浸潤を標的とした放射線治療の可能性, 2015
• ヒト膵癌細胞におけるLPA受容体を介した遊走・浸潤と放射線治療戦略, 第52回群馬放射線腫瘍研究会, 2015
• Depression of p53-independent Akt survival signals after high-LET radiation in mutated p53 cells, The 40th COSPAR Scientific Assembly, 2014
• Stress proteins are induced by space environment, The 40th COSPAR Scientific Assembly, 2014
• ”宇宙遊泳”がゼブラフィッシュ骨格筋へおよぼす影響, 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会, 2016
• 細胞周期調節とDNA修復を分子標的とした炭素線の増感効果, 日本癌治療学会 第54回学術集会, 2016
• 炭素線照射と樹状細胞療法併用による転移抑制効果における樹状細胞の遺伝的背景の影響, 第22回癌治療増感研究会, 2016
• 細胞生存パラメータのLET依存性とNHEJ修復との関係, 第22回癌治療増感研究会, 2016
• The role of Lin28/let7 axis as a target for radiosensitization of melanoma cancer cells, 第22回癌治療増感研究会, 2016
• 温熱によるDNA二本鎖切断は相同組換えで修復される, 日本ハイパーサーミア学会第33回大会, 2016
• 擬似微小重力環境における高精度重粒子線同期照射システムの開発, 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会, 2016
• Development of 3D-clinostat synchronized heavy-ion irradiation system, Asian Microgravity Symposium 2016, 2016
• 宇宙放射線の生物影響研究：これまでとこれから, 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会, 2016
• ISSを利用した植物の太陽粒子線による障害とその修復機構に、微小重力環境が及ぼす影響解析, 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会, 2016
• 小脳培養切片を用いた正常脳の発達に及ぼす重粒子線の影響研究について, 第62回日本宇宙航空環境医学会大会・日本宇宙生物科学会第30回大会, 2016
• 炭素イオン線と樹状細胞併用による転移抑制効果における樹状細胞の遺伝的背景の影響, 日本癌治療学会 第54回学術集会, 2016
• X-ray induced disruption of the blood-brain barrier with the localized change in Claudin5 and the activation of microglia in a normal mouse brain, 第7回国際放射線神経生物科学会, 2017
• マウス移植腫瘍における温熱誘導DNA二本鎖切断, 第21回関東ハイパーサーミア研究会・全身ハイパーサーミア研究会合同学術研究会, 2017
• RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences., 63rd Annual RRS Meeting, 2017
• Development of 3D clinostat synchronized irradiation system for simulating space conditions., 2018 NASA Human Research Program Investigators' Workshop, 2018
• 宇宙放射線と微小重力との複合影響研究, ConBio2017, 2017
• 宇宙居住と宇宙放射線研究, 第32回宇宙環境利用シンポジウム, 2018
• 放射線による細胞死, JASTRO第30回学術大会, 2017
• New p53-targeted gene or chemical chaperone therapy in radiation and hyperthermic oncologies., Eur Symp Hyperthermic Oncol., 2002
• New p53-targeted therapy combined with gene or chemical chaperone therapy with radiation and hyperthernic cancer therapies., 1st Congr Egypt Soci Hyperthermic Therapy., 2002
• New hyperthermic therapies based on p53 gene status., 26th Congr Int Clin Hyperthermia Soc., 2004
• New hyperthermic therapy based on p53 gene status., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• (The young investigator Award of JSHO) Dynamics of DNA damage-recognizing proteins at heat-induced foci., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Accumulation of wild-type p53 is induced by heat treatment in a heat resistant human cancer cell line., 10th Radiat Biol Center Int Symp,, 1993
• Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation., 11th Int Congr Radiat Res., 1999
• New strategy of hyperthermic therapy combined to gene therapy or chemical chaperone therapy., 8th Int Congr Hyperthermic Oncol., 2000
• p53 status-based cancer therapy., Jpn-China Radiat Oncol Symp Kyoto., 2001
• DNA-PK activity plays an important role in radioadaptation by pre-irradiation with low-dose or low-dose rate in mouse spleen., Int Symp Radiat Health., 2001
• DNA-PK activity depressed radioadaptation of apoptosis induced by pre-irradiation at low-dose or low-dose rate in mouse spleen., Int Symp Radiat Homeostasis., 2001
• Radiation-induced apoptosis in scid mouse spleen after low dose-rate irradiation., 1st Radiat Protect Asia-Oceania., 2002
• Radiation-induced apoptosis in Scid mouse spleen after a low-dose irradiation., 34th COSPAR., 2002
• New p53-targeted therapy combined with gene or chemical chaperone therapy., 19th Radiat Biol Cent Int Symp., 2002
• Restoration of mp53 to wtp53 by chemical chaperones brought p53-dependent apoptosis after radiotherapy., 12th Int Congr Radiat Res., 2003
• Analysis of cellular response by exposure to acute or chronic radiation in human lymphoblastoid TK-6 cells., 35th COSPAR., 2004
• The p53 gene status and new p53-targeted therapies of chemical chaperones and high LET radiations for cancer., BAERI Symp., 2005
• Radiation-induced p53-dependent and -independent apoptosis., 1st Asian Congr Radiat Res., 2005
• Radioadaptive response by pre-irradiation at a low dose-rate., World Congr Nncl Med Biol., 2006
• Analysis of mutations of the rpsL gene in E. coli, B. subtilis and S. cerevisiae following long-term space flight on Mir., COSPAR Coll Mutag Cons Space Environ., 2006
• The biological function of radiation-induced nitric oxide radicals through Hdm2-p53 interaction., 13th Int Congr Radiat Res., 2007
• Development of thermotolerance requires interaction between polymerase β and heat shock proteins., 12th Biennial Natl Conf Indian Associat Hyperthermia Oncol Med., 2008
• Heat-induced DNA damage and signal transduction., 4th Int Congr Stress Resp Biol Med., 2009
• Molecular chaperone therapy against human cancer cells., 4th Int Congr Stress Resp Biol Med., 2009
• Cell growth, morphology and cell differentiation of Dictyostelium in space environment., Int Workshop Ultra-long-term Cryogenic Preserv Network Biol Environ Specimens., 1997
• Gene expression of p53-regulated genes in mammalian cultured cells after exposure to space environment., 18th Ann NASA Space Radiat Invest Workshop., 2007
• Possibility of synergism on biological effects of space radiations under microgravity environment., 1st Asian Congr Radiat Res., 2005
• NHEJ pathway and low dose-rate effects (LDRE)., 1st Asian Congr Radiat Res., 2005
• Radioadaptive response by pre-irradiation at a low dose-rate., 5th Jpn-France Workshop Radiobiol Med Imaging., 2004
• Aim, preparation and fight in Rad Gene/LOH space experiments., 5th NIRS Int Open Lab Workshop., 2010
• Reports of “Rad Gene”-space radiation effects on human cells-., 5th NIRS Int Open Lab Workshop., 2010
• Gene expression analysis from human cultured cells frown in space., 5th NIRS Int Open Lab Workshop., 2010
• Light-induced anthocyanin reduces the extent of damage to DNA in UV-irradiated Centaurea cyanus cells in culture., 11th Int Conf Photobiol., 1992
• Induction of wild p53 following γ-irradiation, ultraviolet ray exposure and hyperthermia in a human glioblastoma cell line A-7., 42nd Ann Meeting Radiat Res Society & 14th Ann Meeting North Am Hyperthermic Soci., 1994
• p53-independent accumulation of WAF1 gene expression by heat., 10th Int Congr Radiat Res., 1995
• Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermo sensitivity and stimulates apoptosis by heat stress., 7th Int Congr Hyperthermic Oncol., 1996
• Hyperthermic enhancement of tumor growth inhibition by accelerated carbon-ion in transplantable human esophageal cancer., NIRS Int Sem Heavy Charged Particle Therapy Cancer., 1997
• CDDP induces p53-dependent apoptosis in tangue cancer cells., 1st World Congr Head Neck Oncol., 1998
• Induction of p53-dependent signal transduction by low dose radiations and space environment in rats., 49th Int Astronaut Congr., 1998
• Mutation induction in the rpsL gene on an E. coli-B. subtillis shuttle vector by space flight on MIR., 49th Int Astronaut Congr., 1998
• Accumulation of a tumor suppressor p53 in rat muscle after a space flight., 32nd COSPAR., 1998
• Accumulation of tumor suppressor p53 in rat muscle after space flight., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998
• Cell growth, cell differentiation and morphology of Dictyostelium discoideum in space environment., Joint Pan-Pacific Basin Workshop & 4th Jpn-China Workshop Microgravity Sci., 1998
• Tumor suppressor p53 response by low-dose-rate and chronic radiation., Natl Instit Radiol Sci Int Workshop., 1998
• Accumulation of a tumor suppression p53 in rat muscle after a space flight., Ann Invest Workshop Space Radiat Res., 1998
• Mutation induction by Mir flight in a bacterial rpsL shuttle vector., Ann Invest Workshop Space Radiat Res., 1998
• Mutant p53 gene transfection enhanced radiation-induced radioresistance and G2 arrest in human cancer cells., 11th Int Congr Radiat Res., 1999
• Detection of DNA damage induced by space radiations at Mir-space station and space shuttle by post-labeling of DNA., 11th Int Congr Radiat Res., 1999
• Low-dose-rate radiation attenuates tumor suppressor p53 response., 11th Int Congr Radiat Res Sat Meeting Biol Effects Low Dose Radiat., 1999
• Detection of DNA damage induced by space radiation in the MIR-station and space shuttle by post-labeling of DNA., 10th Ann Space Radiat Health Investigat Workshop., 1999
• New strategy of cancer therapy: Restoration of mutant p53 to normal p53 function by glycerol as a chemical chaperone., 11th Int Congr Radiat Res., 1999
• The effects of microgravity on ligase activity in DNA repair for double strand breaks., 10th Ann Space Radiat Health Investigat Workshop., 1999
• Relationship between p53 status and amounts of hsp72 induction in human cancer cells., 60th Ann Meeting Soci Invest Dermatol., 1999
• Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone., Int Forum Hyperthermia Osaka., 1999
• Differentiation of Dictyostelium discoideum vegetative cells into spores during earth orbit in space., 33rd COSPAR., 2000
• Alkylating agent (MNU)-induced mutation in space environment., 33rd COSPAR., 2000
• The effects of microgravity on induced mutation in E. coli and S. cerevisiae cells., 33rd COSPAR., 2000
• Low-dose and low dose rate radiation attenuates apoptosis through tumor suppressor p53 response., 1st Int Workshop Space Radiat., 2000
• Tumor suppressor p53 response is blunted by low-dose-rate radiation., 10th Int Congr Int Radiat Protect Associat., 2000
• Suppression of p53 and Bax accumulation after X-irradiation by small dose pre-irradiation in radioadaptive survival response of C57BL/6 mice., 10th Int Congr Int Radiat Protect Associat., 2000
• Enzymatic chemical reaction under microgravity environment in space., Ann Int Gravitat Physiol Meeting., 2000
• Unique postural control of upside-down swimming catfish, Synodontis nigriventris, not affected by the change of gravity., Ann Int Gravitat Physiol Meeting., 2000
• The effect of microgravity on induced mutation through DNA synthesis during space flight., 22nd Int Symp Space Technol Sci., 2000
• DNA-PK activity acts radioadaptation of apoptosis induced by pre-irradiation at a low-dose in mouse spleen., 52nd Int Astronaut Congr., 2001
• Radiation-induced apoptosis in SCID mouse spleen after low-dose or low-dose rate irradiation., 2nd Int Coff Eff Low Very Low Doses Ionizing Radiat Human Health Word Council Nuclear Workers., 2001
• Radiation-induced apoptosis in Scid mouse spleen after low-dose or low-dose rate irradiation., 12th Ann Space Radiat Health Investigat Workshop., 2001
• Suppression of X-ray-induced apoptosis by low dose pre-irradiation in the spleen of C57BL/6 mice., Int Symp Radiat Homeostasis., 2001
• Effect of pre-irradiation with X-ray to mice whole body on radiation-induced killing, induction of splenic lymphocyte apoptosis and gene expression of mutated in Ca2+ channel α1A subunit., Int Symp Radiat Homeostasis., 2001
• New strategy of hyperthermic therapy: Combination with gene or molecular chaperone therapy., Godon Conf Radiat Therapy Cancer., 2001
• Pre-irradiation with a low dose-rate depressed radiation-induced TcR gene mutation., Int Symp Biol Effects Low Dose Radiat., 2002
• Enhanced radiation-induced fatal sensitivity and splenic lymphocyte apoptosis in mice with mutation in P/Q-type Ca2+ channel α1A subunit gene., Int Symp Biol Effects Low Dose Radiat., 2002
• Analysis of radiosensitivity in human squamous cell carcinoma cells with different p53 genetic status using cDNA microarray., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002
• Glycerol enhances CDDP-induced growth inhibition of mutant p53 tumors., 6th Res Workshop Biol Prev Treat Head Neck Cancer., 2002
• Radiation biology in space: DNA damage and biological effects of space radiation., 1st Asia Congr Photobiol., 2002
• Effects of an HSP inhibitor, KNK437, on heat sensitivity and heat tolerance., 3rd Asia Congr Hypthermic Oncol., 2002
• p53-dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET., 3rd Asia Congr Hypthermic Oncol., 2002
• Detection of DNA damage induced by space radiation in Mir and Space Shuttle., 2nd Int Workshop Space Radiat Res., 2002
• Pre-irradiation at a low-dose-rate blunted tumor suppressor p53 response., 2nd Int Workshop Space Radiat Res., 2002
• The effect of microgravity on induced mutation through DNA synthesis during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Radiation microbiology in space environment conducted using space shuttle and space station Mir., 2nd Int Workshop Space Radiat Res., 2002
• Repair system for DNA damages in meiotic cells of Caenorhabditis elegans., 2nd Int Workshop Space Radiat Res., 2002
• Radiation responses of survival and splenic lymphocyte apoptosis in rolling mouse Nagoya following low-dose pre-irradiation., 2nd Int Workshop Space Radiat Res., 2002
• Radiation-induced gene expression about apoptosis-related genes by DNA array analysis., 2nd Int Workshop Space Radiat Res., 2002
• The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae during space flight., 2nd Int Workshop Space Radiat Res., 2002
• The effects of microgravity on ligase activity in DNA repair of double-strand breaks during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Differentiation of Dictyostelium discoideum during space flight., 2nd Int Workshop Space Radiat Res., 2002
• Mutation frequency of plasmid DNA and Escherichia coli by long-term space flight on Mir., 2nd Int Workshop Space Radiat Res., 2002
• Sensitization by glycerol for CDDP-therapy against mutant p53 tumors., 7th Japan-Taiwan Conf Otolaryngol Head Neck Surg., 2003
• New p53-targeted cancer therapies combined with chemical or molecular chaperone., 1st Int Congr Stress Resp Biol Med., 2003
• Gene expression after X-irradiation and/or glycerol in human anaplastic carcinoma cells harboring mutated p53 gene., 12th Int Congr Radiat Res., 2003
• Pre-irradiation at a low dose-rate blunted p53 response., 12th Int Congr Radiat Res., 2003
• Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene., 12th Int Congr Radiat Res., 2003
• The mechanism of radiation adaptive response., Conf Recent Trend Radiat Biol., 2004
• Glycerol restores radio-sensitivity of transplanted mp53 tumors., 6th Int Conf Head Neck Cancer., 2004
• Expression of gene and protein after CDDP and/or glycerol treatment of mutated p53 cells., 6th Int Conf Head Neck Cancer., 2004
• Dorsal light reflex is absent in the postural control system of the upside-down swimming catfish, Synodontis nigriventris., 35th COSPAR., 2004
• Heat sensitization by inhibitors targeted for signaling factors of cellular survival., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• Evidence for DSBs as a critical trigger of heat-induced cell killing., Appl Thermal Stress Improve Health Cons Prop, Kadota Fund Int Forum., 2004
• High-LET radiation enhanced p53-independent apoptosis., 3rd Int Workshop Space Radiat., 2004
• Effects of mild hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, referring to the effect on intratumor quiescent cells., 9th Int Congr Hyperthermic Oncol., 2004
• DSB is the targets of cell killing induced by heat., 9th Int Congr Hyperthermic Oncol., 2004
• Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53., 9th Int Congr Hyperthermic Oncol., 2004
• Heat sensitizers-targeted for anti-apoptosis signal transduction pathways in human cultured cancer cells., 9th Int Congr Hyperthermic Oncol., 2004
• Mediation of NBS1 to radiation-induced cellular survival signaling pathway via NF-κB., 1st Asian Congr Radiat Res., 2005
• p53-independent enhancement of radiation sensitivity by siRNA targeted for NBS1 in human tongue cancer cells., 1st Asian Congr Radiat Res., 2005
• Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 1st Asian Congr Radiat Res., 2005
• Heat sensitization by PD98059, an inhibitor targeted for MAPK cascade., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Heat sensitization by targeting heat-induced cell survival signal transduction through Akt., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Apoptosis-related protein expression after hyperthermia in human tongue squamous cell carcinoma cells harboring wild-type or mutated-type p53 with protein microarray., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• The role of polymerase β and HSPs on the thermo-tolerance., 4th Asian Congr Hyperthermic Oncol & 23rd Japan Congr Hyperthermic Oncol., 2006
• Radioadaptive response by low or high LET-radiation., 36th COSPAR., 2006
• Analysis of matrix proteins of otolith in upside-down catfish., 36th COSPAR., 2006
• Phosphorylation of DNA damage-recognizing proteins at heavy-ion track., 36th COSPAR., 2006
• Dynamics of DNA damage-recognizing proteins at heavy-ion-induced track., 4th Int Workshop Space Radiat Res., 2006
• Review: Interaction of microgravity and space radiations., 27th Ann Int Gravit Phys Meeting., 2006
• p53-independent heat sensitization of lung cancer cells by PD98059, an inhibitor targeting for MAPK cascade., 12th Congr Asian Pacific Soc Respirol., 2007
• siRNA targeting NBS1 increases radiation sensitivity of human cancer cells in a p53-independent manner., 13th Int Congr Radiat Res., 2007
• Cellular sensitivity and p53-independent apoptosis on human gingival cancer cells by heavy-ion beams., 13th Int Congr Radiat Res., 2007
• Spatio-temporal responses to different UV wavelengths in human skin organ culture., 13th Int Congr Radiat Res., 2007
• High-LET radiations enhanced apoptosis regardless of p53 status., 13th Int Congr Radiat Res., 2007
• Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks., 13th Int Congr Radiat Res., 2007
• Preparation for ISS experiment; biological influences of space radiation and microgravity., 15th Int Acad Astron., 2007
• Heat-induced DNA strand breaks and their repair., 8th ICHS Annual-Convention & 4th Biennel Natl Meet Int Associat Hyperthermic Oncol Med., 2007
• The p53-dependent radioadaptive response., 37th COSPAR., 2008
• Phospho-Nbs1 and Mre11 proteins which recognize DSBs co-localize with ？H2AX in the nucleus after heat treatment., Ataxia-Telangiectasia Workshop 2008., 2008
• Hdm2 and NO radicals contribute to the p53-dependent radioadaptive response., Ataxia-Telangiectasia Workshop 2008., 2008
• The study of target genes deciding heat-sensitivity., 10th Int Congr Hyperthermic Oncol., 2008
• Development of thermotolerance requires interaction between polymerase β and heat shock protein., 10th Int Congr Hyperthermic Oncol., 2008
• Tween80 enhances heat-induced arrest of cell proliferation through regulating Akt and NBS1 signaling pathways., 10th Int Congr Hyperthermic Oncol., 2008
• A low dose pre-irradiation induces radio- and heat- resistance via HDM2 and NO radicals, and is associated with p53 functioning., Int Conf Radiat Damage Biomol Systems., 2009
• DNA-DSB recognition proteins localize along heavy-ion induced tracks in the cell nucleus., Heavy Ions Ther Space Symp., 2009
• The molecular mechanism of p53-dependent radioadaptive response by NO radicals., Heavy Ions Ther Space Symp., 2009
• The molecular mechanism of radioadaptive response., 2nd Asian Congr Radiat Res., 2009
• Cell death induced by high LET and low LET radiations., 2nd Asian Congr Radiat Res., 2009
• NO radicals choreograph p53-different radio-sensitivity in human lung cancer cells., 2nd Asian Congr Radiat Res., 2009
• Protein microarray analysis of apoptosis-related protein expression following heat shock in human toungue squamous cell carcinomas containing different p53 phenotypes., 2nd Asian Congr Radiat Res., 2009
• The therapeutic target of DNA repair pathways against alkylating agents., 2nd Asian Congr Radiat Res., 2009
• Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity in lung cancer cells bearing different p53 gene status., 2nd Asian Congr Radiat Res., 2009
• Formaldehyde-induced DNA damage and its repair., 2nd Asian Congr Radiat Res., 2009
• Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells., 2nd Asian Congr Radiat Res., 2009
• Space experiment “Rad Gene”-report 1; p53-Dependent gene expression in human cultured cells exposed to space environment., 38th COSPAR., 2010
• Space experiment “Rad Gene”-report; Detection of DNA damage and adaptive response activity of human cells exposed to space radiations., 38th COSPAR., 2010
• Cell lethality by carbon- Ion beams in X-ray resistant cells., 51st Ann Meeting of Particle Therapy Co-operative Group, 2012
• Expression of genes and proteins in human cultured lymphoblastoid cells during spaceflight., 39th COSPAR, 2012
• Recent advances in the biology of carbon-ion cancer therapy, KHIMA Seminar on Heavy-ion Radiotherapy, 2012
• A priming heat treatment can induce the development of heat- and radio-resistance via HSPs, regardless of p53-gene status., 11th Int Congr Hyperthermic Oncol., 2012
• Heat treatment as well as X-ray-irradiation depresses gastric mucosal damage induced with restraint plus water-immersion stress through HSP-induction in mice., 11th Int Congr Hyperthermic Oncol., 2012
• ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating., 11th Int Congr Hyperthermic Oncol., 2012
• Hyperthermic sensitization efficacy as a target of homologous recombination repair pathways in the oral cancer cells., 11th Int Congr Hyperthermic Oncol., 2012
• Space experiment of “Rad Gene” in ISS Kibo: Radiation effects in human cultured cells., 3rd Asian Congress of Radiation Research (ACRR2013)., 2013
• LET-dependent biological effect of DNA DSB repair on cell killing., Ion Therapy and Space Radiation Symposium 2013 (HITSRS2013)., 2013
• LET-dependent biological effect of DNA double-strand break repair on radiosensitivity., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013
• Combination effect of carbon-ion beams and DNA repair inhibitor and/or cell cycle regulation inhibitor on cell killing in lung cancer cells., 52nd Ann Meeting of Particle Therapy Co-operative Group (PTCOG52)., 2013
• Depression of p53-independent Akt survival signals in human oral cancer cells after exposure to high-LET radiation., Asian Congress of Radiation Research (ACRR2013)., 2013
• Achievement of the first life science experiments in the Japanese Experimental Module "Kibo" of the ISS, The 28th International Symposium on Space Technology and Science, 2011
• Long term stay against space radiation for human health, The 28th International Symposium on Space Technology and Science, 2011
• FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ, ICRR 2011, 2011
• Space radiation effects on human cultured cells in an International Space Station at Kibo module, ICRR 2011, 2011
• NHEJ plays a more important role than HR in defining radiosensitivity after exposure to high-LET radiation, ICRR2015, 2015
• Carbon-ion beams efficiently induce cell killing in X-ray resistant human squamous tongue cancer cells, SRHIT2015, 2015
• Enhancement of heat sensitivity of human cancer cells by HR inhibitor B02 but not NHEJ inhibitor NU7026., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol, 2014
• Research of biological effect by solar radiation using exposure area at ISS platform., 2014
• Enhancement of heat sensitivity by depression of homologous recombination repair., 6th Asian Congr Hyperthermic Oncol & 31st Japan Congr Hyperthermic Oncol., 2014
• Increase in cell motility by C-ion irradiation and its inhibition by the ROCK inhibitor in lung adenocarcinoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53), 2014
• Combination effect of carbon-ion beams and cell cycle regulation inhibitor on cell killing in lung cancer cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014
• Relation between sensitivity to carbon-ion beams and expression of cancer stem cell marker in melanoma cells., 53rd Ann Meeting of Particle Therapy Co-operative Group (PTCOG53)., 2014
• Enhancement of heat sensitivity of human cancer cells by inhibitor of HR but not NHEJ, ICHO2016, 2016
• Carbon ion irradiation abrogates Lin28B-induced X-ray resistance in melanoma cells, PTCOG56, 2017
• Performance evaluation of new devices to synchronize X-ray or heavy-ion irradiation and simulated microgravity for space radiation research, ISTS2017, 2017
• New devices to synchronize irradiation and simulated microgravity for space radiation research, ISSRPRT, 2017
• Heat induces DNA double strand breaks under hypoxia, The 7th Asian Congress of Hyperthermic Oncology, 2018
• Anti-tumor and anti-metastasis effects of carbon-ion radiotherapy combined with anti-CTLA4 antibody, PTCOG57, 2018
• Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632., ICRR2015, 2015
• Effect of DSB repair on cell killing by radiation with different LET values, 2015
• Targeting carbon-ion beams-induced G2 checkpoint activation with the Wee-1 inhibitor MK-1775 in lung cancer cells, 2015
• Depression of p53-independent Akt survival signals after high-LET radiation in mutated p53 cells, The 40th COSPAR Scientific Assembly, 2014
• Stress proteins are induced by space environment, The 40th COSPAR Scientific Assembly, 2014
• Development of 3D-clinostat synchronized heavy-ion irradiation system, Asian Microgravity Symposium 2016, 2016
• RNAseq profiling to analyze the combined effects on radiation under simulated microgravity for space biosciences., 63rd Annual RRS Meeting, 2017
• Development of 3D clinostat synchronized irradiation system for simulating space conditions., 2018 NASA Human Research Program Investigators' Workshop, 2018
• 月や火星の低重力と低線量率放射線の複合環境模擬装置の開発, 山之内 佐久也; 竹内 和臣; 高橋 祥吾; 田代 睦; 日出間 純; 東谷 篤志; 安達 拓也; Shenke Zhang; Fady Nagy Lotfy Guirguis; 吉田 由香里; 永松 愛子; 秦 恵; 竹内 邦人; 高橋 亨; 関冨 勇治; 髙橋 昭久, 日本放射線影響学第63回大会, 15 Oct. 2020, 16 Oct. 2020, Japanese
• APCMin/+マウスを用いた宇宙空間模擬環境による生体影響評価, 鈴木 健之; 鶴岡 千鶴; 上西 睦美; 岡部 まゆみ; 遠坂 歌子; 柳原 啓見; 神戸 崚輔; 吉田 由香里; 武島 嗣英; 森岡 孝満; 大平 充宣; 髙橋 昭久; 柿沼 志津子, 日本放射線影響学第63回大会, 15 Oct. 2020, 16 Oct. 2020, Japanese
• 模擬宇宙環境のDNA損傷修復カイネティクスへの影響, 大泉 昂之; 山邊 聡一郎; 山之内 佐久也; 舟山 知夫; 髙橋 昭久; 中村 麻子, 日本放射線影響学第63回大会, 15 Oct. 2020, 16 Oct. 2020, Japanese
• 3Dクリノスタット同期照射システムとヒト線維芽細胞における細胞周期関連遺伝子の発現プロファイル変化, 池田 裕子; 村谷 匡史; 日出間 純; 秦 恵; 藤原 敬己; 想田 光; 吉田 由香里; 髙橋 昭久, 日本放射線影響学第63回大会, 15 Oct. 2020, 16 Oct. 2020, Japanese
• 深宇宙，月，火星を模擬した装置開発, 髙橋 昭久; 山之内 佐久也; 竹内 和臣; 高橋 祥吾; 田代 睦; 日出間 純; 東谷 篤志; 安達 拓也; Shenke Zhang; Fady Nagy Lotfy Guirguis; 吉田 由香里; 永松 愛子; 秦 恵; 竹内 邦人; 高橋 亨; 関冨 勇治, 日本マイクログラビティ応用学会 第32回学術講演会, 07 Oct. 2020, Japanese
• マウスを用いた宇宙空間模擬環境による生体影響評価, 柿沼志津子; 鈴木健之; 鶴岡千鶴; 森岡孝満; 柳原啓見; 神戸崚輔; 髙橋昭久, 日本マイクログラビティ応用学会 第32回学術講演会, 07 Oct. 2020, Japanese
• マウスを用いた宇宙空間模擬環境による生体影響評価, 柿沼志津子，鈴木健之，鶴岡千鶴，森岡孝満，柳原啓見，神戸崚輔，髙橋昭久, マイクログラビティ学会第32回大会, 07 Oct. 2020, Japanese, Japan, Domestic conference
• 3Dクリノスタット同期照射システムとヒト線維芽細胞における細胞周期関連遺伝子の発現プロファイル変化, 池田裕子，村谷匡史，日出間純，秦恵，藤原敬己，想田光，吉田由香里，髙橋昭久, 日本放射線影響学会第63回大会, 15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference
• 模擬宇宙環境のDNA損傷修復カイネティクスへの影響, 大泉昂之，山邊聡一郎，山之内佐久也，舟山知夫，髙橋昭久，中村麻子, 日本放射線影響学会第63回大会, 15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference
• 月や火星の低重力と低線量率放射線の複合環境模擬装置の開発, 山之内佐久也，竹内和臣，高橋祥吾，田代睦，日出間純，東谷篤志，安達拓也，Shenke Zhang，Fady Nagy Lotfy Guirguis，吉田由香里，永松愛子，秦恵，竹内邦人，高橋亨，関冨勇治，髙橋昭久, 日本放射線影響学会第63回大会, 15 Oct. 2020, 15 Oct. 2020, 31 Oct. 2020, Japanese, Japan, Domestic conference
• X線照射後の代償性肝肥大, 安達拓也，吉田由香里，八高知子，渋谷圭，髙橋昭久, 第58回群馬放射線腫瘍研究会, 06 Feb. 2021, Japanese, Japan, Domestic conference
• Dose cancer progress in space?, Akihisa Takahashi, 43rd COSPAR, 02 Feb. 2021, English, Australia, International conference
• Combined effects of radiation and simulated microgravity on decreased locomotor activity in the normal mouse brain, Yukari Yoshida, David Fernandez-Quezada, Sonia Luquin de Anda, Akihisa Takahashi, Araceli Espinosa-Jeffrey, 43rd COSPAR, 02 Feb. 2021, English, Australia, International conference
• Increased chromosome aberrations in human cells exposed simultaneously to simulated microgravity and radiation, Megumi Hada, Sakuya Yamanouchi, Jordan Rhone, Jian-Hua Mao, Hiroko Ikeda, Ianik Plante, Keigi Fujiwara, Premkumar Saganti, Akihisa Takahashi, NASA HRP-IWS, 03 Feb. 2021, English, United States, International conference
• Study on the preventive and therapeutic effects of melatonin on diseases caused by space: Analysis using fish scales on board a satellite, 鈴木信雄; 平山順; 髙橋昭久; 小林功; 小林静静; 黒田康平; 瀧野晴美; 保田夏野; 木村-須田廣美; 村尾美羽; 池田わたる; 上野宗一郎; 田渕圭章; 古澤之裕; 池亀美華; 本田匡人; 遠藤雅人; 丸山雄介; 松原創; 中野貴由; 三島弘幸; 加藤晴康; 関あずさ; 永松愛子; 橋本博文; 服部淳彦, 第39回宇宙環境利用シンポジウム, 21 Jan. 2025, 21 Jan. 2025, 22 Jan. 2025, Japanese
• Future outlook for science for human planetary habitation in space, Akihisa Takahashi, 第39回宇宙環境利用シンポジウム, 21 Jan. 2025, 21 Jan. 2025, 22 Jan. 2025, Japanese
• 宇宙空間、月と火星を模擬した重力と放射線同時曝露による生物影響, 髙橋昭久, 重力天体着陸シンポジウム, 10 Jan. 2025, 09 Jan. 2025, 10 Jan. 2025, Japanese
• 人工衛星を用いた宇宙実験のための基礎的な解析：ゼブ ラフィッシュのウロコを用いた解析, 瀧野晴美; 小林静静; 小林 功; 黒田康平; 丸山雄介; 池田わたる; 上野; 宗一郎; 松原 創; 本田匡人; 古澤之裕; 田渕圭章; 三島弘幸; 池亀美華; 髙橋昭久; 平山 順; 服部淳彦; 鈴木信雄, 令和６年日本動物学会・中部支部福井大会, 08 Dec. 2024, 07 Dec. 2024, 08 Dec. 2024, Japanese
• 炭素イオン線超高線量率照射がマウス皮膚早期反応に与える影響, 吉田由香里; 須田 裕夢; 田代 睦; 遊佐 顕; 中尾 政夫; 髙橋 昭久; 大野 達也, 第4回日本量子医科学会学術大会, 07 Dec. 2024, 06 Dec. 2024, 07 Dec. 2024, Japanese
• 宇宙生活者の健康のために, 髙橋昭久, 第21回日本健康・栄養システム学会九州地方会, 23 Nov. 2024, 23 Nov. 2024, 23 Nov. 2024, Japanese
• 宇宙で がんの進行は早まる？, 髙橋昭久, 第70回日本宇宙航空環境医学会, 17 Nov. 2024, 16 Nov. 2024, 17 Nov. 2024, Japanese
• 宇宙実験：これまでとこれから, 髙橋昭久, 令和6年度IGMセミナー, 14 Nov. 2024, 14 Nov. 2024, 14 Nov. 2024, Japanese
• 宇宙実験から学んだこと, 髙橋昭久, 第1回宇宙ｘライフサイエンス技術者会議, 08 Oct. 2024, 08 Oct. 2024, 08 Oct. 2024, Japanese
• The Effect of Carbon Ion Ultra-high Dose Rate Irradiation on Proliferation in Mouse Osteosarcoma Cells, Hiromu Suda; Yukari Yoshida; Akihisa Takahashi; Tatsuya Ohno, 日本放射線影響学会第67回大会, 26 Sep. 2024, 25 Sep. 2024, 28 Sep. 2024, English
• Biological effects of FLASH carbon-ion irradiation on normal tissues, Yukari Yoshida; Hiromu Suda; Wenteng Cao; Mutsumi Tashiro; Ken Yusa; Masao Nakao; Akihisa Takahashi; Tatsuya Ohno, 日本放射線影響学会第67回大会, 25 Sep. 2024, 25 Sep. 2024, 28 Sep. 2024, English
• My research history for;Living in Space, Akihisa Takahashi, 2nd Korea-US Space Medicine Symposium, 25 Sep. 2024, 25 Sep. 2024, 25 Sep. 2024, English
• キンギョの再生ウロコの低温保存と重力応答：人工衛星を用いた宇宙実験を目指して, 鈴木信雄; 瀧野晴美; 小林静静; 小林 功; 黒田康平; 丸山雄介; 池田わたる; 上野宗一郎; 池亀美華; 遠藤雅人; 木村-須田廣美; 中野貴由; 関 あずさ; 三島弘幸; 松原 創; 本田匡人; 古澤之裕; 田渕圭章; 矢野幸子; 永松愛子; 橋本博文; 嶋津 徹; 髙橋昭久; 平山 順; 服部淳彦, 日本宇宙生物科学会第 38 回大会, 20 Sep. 2024, 20 Sep. 2024, 23 Sep. 2024, Japanese
• 光る移植細胞を免疫サーベイランスからアンロック ―がんの 浸潤・転移のリアルタイム追跡を可能にー, 阪上-沢野朝子; 髙橋昭久; 宮脇敦史, 日本宇宙生物科学会第 38 回大会, 20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese
• 重力変動ががん細胞の薬物応答性に与える影響の解析, 平田大賀; 髙橋昭久; 園下将大, 日本宇宙生物科学会第 38 回大会, 20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese
• 「きぼう」利用宇宙実験のための 減光フィルター保定具の開発, 髙橋昭久, 日本宇宙生物科学会第 38 回大会, 20 Sep. 2024, 20 Sep. 2024, 22 Sep. 2024, Japanese
• Disparity in the effect of partial gravity simulated using a new apparatus on different rat hindlimb muscles, Shengli Zhang; Shenke Zhang; Zhen Wang; Takuya Adachi; Yukari Yoshida; Akihisa Takahashi, 第71回北関東医学総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, English
• Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, 第71回北関東医学総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, English
• 炭素線超高線量率照射によるマウス骨肉腫細胞の生存率に与える影響, 須田裕夢; 吉田由香里; 髙橋昭久; 大野達也, 第71回北関東医学会総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese
• Combined effects of radiation and simulated microgravity on intestinal tumorigeness in ApcMin/+ mice, Chizuru Tsuruoka; Kenshi Suzuki; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, COSPAR2024, 19 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English
• INCREASED CHROMOSOME ABERRATIONS IN HUMAN CELLS EXPOSED TO SIMULATED MICROGRAVITY AND RADIATION SIMULTANEOUSLY, Premkumar Saganti; Megumi Hada; Hiroko Ikeda; Ianik Plante; Jian-Hua Mao; Alexandros G. Georgakilas; Akihisa Takahashi; Ioannis Michalopoulos, COSPAR2024, 14 Jul. 2024, 13 Jul. 2024, 20 Jul. 2024, English
• マウス急性皮膚反応における炭素イオン線超高線量率照射の影響, 吉田由香里; 須田裕夢; 田代 睦; 遊佐 顕; 中尾政夫; 髙橋昭久; 大野達也, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, Japanese
• Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, English
• 炭素線超高線量率照射によるがん細胞の細胞死および細胞周期に及ぼす影響, 須田裕夢; 吉田由香里; 髙橋昭久; 大野達也, 第61回日本放射線腫瘍学会生物部会学術大会, 17 May 2024, 17 May 2024, 17 May 2024, Japanese
• Analysis of FLASH effect with carbon-ion beams in vivo study, Yukari Yoshida; Hiromu Suda; Mutsumi Tashiro; Ken Yusa; Masao Nakao; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• Biological effect of FLASH carbon ions in the mouse intestine, Wenteng Cao; Yukari Yoshida; Hiromu Suda; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• Biological response of cancer cells to carbon FLASH irradiation, Hiromu Suda; Yukari Yoshida; Akihisa Takahashi; Tatsuya Ohno, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• Combined effects of radiation and simulated microgravity on intestinal tumorigenesis in C3B6F1 ApcMin/+ mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Hitomi Seo; Mari Ogawa; Ryosuke Kambe; Tatsuhiko Imaoka; Shizuko Kakinuma; Akihisa Takahashi, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• Differential gene expression in human fibroblasts using a Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity change (SwiNG), Polina Malatesta; Konstantinos Kyriakidis; Megumi Hada; Hiroko Ikeda; Akihisa Takahashi; Premkumar Saganti; Alexandros Georgakilas; Ioannis Michalopoulos, ISRN2024, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• DIFFERENTIAL GENE EXPRESSION IN HUMAN FIBROBLASTS SIMULTANEOUSLY EXPOSED TO PARTIAL GRAVITY AND LOW DOSE-RATE NEUTRONS, P. Malatesta; K. Kyriakidis; M. Hada; H. Ikeda; A. Takahashi; P. B. Saganti; A. G. Georgakilas; I. Michalopoulos, NASA HRP meeting 2024, 16 Feb. 2024
• Study of melatonin as an effective therapeutic agent for various diseases in astronauts, Nobuo Suzuki; Jun Hirayama; Akihisa Takahashi; Kouhei Kuroda; Natsuno Yasuda; Yoshiaki Tabuchi; Yukihiro Furusawa; Mika Ikegame; Kazuki Watanabe; Yusuke Maruyama; Hajime Matsubara; Takayoshi Nakano; Hiromi Kimura-Suda; Ryotaro Kawamura; Hiroyuki Mishima; Haruyasu Kato; Azusa Seki; Atsuhiko Hattori, SUS38, 16 Jan. 2024, 16 Jan. 2024, 17 Jan. 2024, Japanese
• Biological Combined Effects of Simultaneous Exposure to Low-dose-rate Radiation and Partial Gravity Simulation the Moon, A.Takahashi; J-H Mao; P.B.Saganti; M,Hada, 7th GLOBAl MOON VILLAGE WORKSHOP＆ SYMPOSIUM, 07 Dec. 2023, 06 Dec. 2023, 10 Dec. 2023, English
• 宇宙放射線の生物影響を探る, 髙橋 昭久, 2023年度日本アイソトープ協会シンポジウム, 01 Dec. 2023, 01 Dec. 2023, 01 Dec. 2023, Japanese
• 宇宙空間における新規メラトニン誘導体のウロコの骨代謝に対する効果と地 上における骨疾患モデル動物を用いた解析, 鈴木信雄; 古澤之裕; 田渕圭章; 豊田賢治; 関あずさ; 高垣裕子; 染井正徳; 江尻貞一; 池亀美華; 黒田康平; 関口俊男; 松原 創; 高橋昭久; 平山 順; 服部淳彦, 日本宇宙生物科学会第37回大会, 24 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese
• 消化管腫瘍モデルマウスを用いた​ 宇宙模擬環境による発がん影響評価, 鈴木健之; 鶴岡千鶴; 森岡孝満; 今岡達彦; 髙橋昭久; 柿沼志津子, 日本宇宙生物科学会第37回大会, 23 Sep. 2023, 23 Sep. 2023, 24 Sep. 2023, Japanese
• 「きぼう」利用宇宙実験のための右第5乳房脂肪体移植実験器具の開発, 髙橋 昭久, 日本宇宙生物科学会 第37回大会, 24 Sep. 2023, 22 Sep. 2023, 24 Sep. 2023, Japanese
• Ground simulation experiment: Chromosome aberration frequencies due to space radiation exposure on the Moon and Mars, Akihisa Takahashi; Hiroko Ikeda; Jian-Hua Mao; Premkumar B. Saganti; Megumi Hada, ISRN2023, 04 Mar. 2023, English
• 宇宙での放射線と重力変化の複合影響, 髙橋 昭久, 宇宙ユニットシンポジウム2023, 12 Feb. 2023, Japanese
• Differential gene expression in human fibroblasts simultaneously exposed to radiation and simulated microgravity, P. Malatesta; H. Ikeda; A. Takahashi; M. Hada; A. G. Georgakilas; I. Michalopoulos, NASA HRP meeting2023, 09 Feb. 2023, English
• Chromosome aberration induction by simulation environment of outer space, Moon and Mars, Akihisa Takahashi; Hiroko Ikeda; Jian-Hua Mao; Premkumar B. Saganti; Megumi Hada, 2nd JSQMS meeting, 09 Dec. 2022, English
• Deep space and mitochondria, Akihisa Takahashi, JPW2022, 02 Dec. 2022, English
• FLASH carbon-ion irradiation~First report: construction of system and cultur ed cell experiments~, Yukari Yoshida; Mutsumi Tashiro; Takahiro Oike; Masao Nakao; Ken Yusa; Yuka Hirota; Akihisa Takahashi; Tatsuya Ohno, 日本放射線腫瘍学会第35回学術大会, Nov. 2022, 10 Nov. 2022, 12 Nov. 2022, Japanese
• Expression profile of cell cycle / aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, H. Ikeda; M. Hada; A. Takahashi, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English
• The early proteomic responses of cultured mammalian cells exposed to simulated microgravity, Zhenlin Ju; Jing Wang; Megumi Hada; Akihisa Takahashi; Keigi Fujiwara, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English
• ncreases chromosome aberrations in human cells exposed simultaneously to simulated microgravity and neutron, M. Hada; H. Ikeda; P.B. Saganti; A. Takahashi, ASGSR 2022, Nov. 2022, 09 Nov. 2022, 12 Nov. 2022, English
• Adenosine agonist treatment increases radioresistance in vitro and in vivo, Anggraeini Puspitasari; Matteo Cerri; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Martina Quartieri; Cristina Totis; Olga Sokol; Palma Simonello; Marco Durante; Walter Tinganelli, RRS2022, 17 Oct. 2022, 16 Oct. 2022, 19 Oct. 2022, English
• 量子科学技術と宇宙医学, 髙橋 昭久, 令和４年度量子医療推進講演会, 15 Oct. 2022, 15 Oct. 2022, 15 Oct. 2022, Japanese
• Adenosine Agonist treatment shows protective effects to C-ion irradiation, Anggraeini Puspitasari; Matteo Cerri; Fabio Squarcio; Akihisa Takahashi; Yukari Yoshida; Kenji Hanamura; Martina Quartieri; Cristina Totis; Palma Simonello; Marco Durante; Walter Tinganelli, ERRS2022, 21 Sep. 2022, 21 Sep. 2022, 24 Sep. 2022, English
• Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons using SwiNG, Akihisa Takahashi; Hiroko Ikeda; Megumi Hada, 日本宇宙生物学会第65回大会, Sep. 2022, 17 Sep. 2022, 18 Sep. 2022, Japanese
• The synergistic effects of radiation and simulated microgravity to expression profile changes of cell cycle / aging-related genes in human fibroblasts, Hiroko Ikeda; Megumi Hada; Akihisa Takahashi, 日本放射線影響学会第65回大会, 16 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, Japanese
• Chromosome aberration induction by simultaneous exposure of partial gravity and low dose-rate neutrons simulating outer space, the Moon, and Mars, Akihisa Takahashi; Hiroko Ikeda; Megumi Hada, 日本放射線影響学会第65回大会, 15 Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, English
• First trial of cell experiments with FLASH carbon-ion irradiation, Yukari Yoshida; Mutsumi Tashiro; Takahiro Oike; Masao Nakao; Ken Yusa; Yuka Hirota; Akihisa Takahashi; Tatsuya Ohno, 日本放射線影響学会第65回大会, Sep. 2022, 15 Sep. 2022, 17 Sep. 2022, Japanese
• Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Akihisa Takahashi; Hiroko Ikeda; Nagy Lotfy Guiriuis; Yukari Yoshida; Fady; Megumi Hada, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English
• Increases chromosome aberrations in human cells exposed to simulated microgravity and radiation simultaneously, M. Hada; H. Ikeda; J-H. Mao; P.B. Saganti; A. Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English
• Expression profile of cell cycle or aging-related genes in human fibroblasts exposed simultaneously to radiation and simulated microgravity, Hiroko Ikeda; Megumi Hada; Akihisa Takahashi, 44th COSPAR Scientific Assembly, 22 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English
• Evaluation of cancer risk in space simulated environment using APCMin / + mice, Kenshi Suzuki; Chizuru Tsuruoka; Takamitsu Morioka; Akihisa Takahashi; Shizuko Kakinuma, 44th COSPAR Scientific Assembly, 19 Jul. 2022, 16 Jul. 2022, 24 Jul. 2022, English
• ラット肝臓における放射線照射後の代償性反応の解明 -肝肥大の術前応用に向けて-, 安達 拓也; 吉田 由香里; 八高 知子; 渋谷 圭; 浦岡 俊夫; 髙橋 昭久, 第59回日本放射線腫瘍学会生物部会学術大会・第50回放射線による制癌シンポジウム, 24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese
• 肝正常組織における炭素イオン線分割照射の生物学的考察のための基礎的検討, 吉田 由香里; 安達 拓也; Shenke Zhang; 須田 裕夢; 髙橋 昭久, 第59回日本放射線腫瘍学会生物部会学術大会・第50回放射線による制癌シンポジウム, 24 Jun. 2022, 24 Jun. 2022, 25 Jun. 2022, Japanese
• Invitation to “space medicine”, Akihisa Takahashi, The 123rd scientific meeting of the Japan Society of Medical Physics (JSMP), 16 Apr. 2022, 14 Apr. 2022, 18 Apr. 2022, Japanese
• My future dream through "Living in Space", Akihisa Takahashi, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, English
• Development of the Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity-change (SwiNG), Guirguis FNL; Yamanouchi S; Takeuchi K; Takahashi S; Tashiro M; Hidema J; Higashitani A; Adachi T; Zhang S; Yoshida Y; Nagamatsu A; Hada M; Takeuchi K; Takahashi T; Sekitomi Y; Takahashi A, ISRN-2022, 19 Mar. 2022, 19 Mar. 2022, 19 Mar. 2022, English
• Early Responses of Cultured Mammalian Cells to Altered Gravitational Vector: Adaptation to Microgravity and Changes in Cell Motility., Zhenlin Ju; Yi-Jen Chiu; Tamlyn N. Thomas; Sakuya Yamanouchi; Yukari Yoshida; Jun-ichi Abe; Akihisa Takahashi; Jing Wang; Keigi Fujiwara; Megumi Hada, NASA HRP IWS meeting 2022, 10 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English
• SwiNG: Combined-environment simulator of Moon and Mars, A. Takahashi; S. Yamanouchi; K. Takeuchi; S. Takahashi; M. Tashiro. Hidema; A. Higashitani; T. Adachi; S. Zhang; F.N.L. Guirguis; Y. Yoshida; A. Nagamatsu; M. Hada; K. Takeuchi; T. Takahashi; Y. Sekitomi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English
• Comprehensive gene expression analysis of human fibroblasts using 3D clinostat synchronized irradiation systems, Hiroko Ikeda; Megumi Hada; Alkihisa Takahashi, NASA HRP IWS meeting 2022, 09 Feb. 2022, 07 Feb. 2022, 10 Feb. 2022, English
• Combined effects of space radiation and variable gravity -2021 Annual Report-, TAKAHASHI Akihisa; SUZUKI Kenshi; TSURUOKA Chizuru; MORIOKA Takamistu; TAKESHIMA Tsuguhide; YOSHIDA Yukari; NAKAMURA Asako; IKEDA Hiroko; HADA Megumi; NAGAMATSU Aiko; OHIRA Yoshinobu; INATOMI Yuko; KAKINUMA Shizuko, 第36回 宇宙環境利用シンポジウム, 18 Jan. 2022, 18 Jan. 2022, 19 Jan. 2022, Japanese
• Increased Chromosome Aberrations in Human Cells Exposed Simultaneously to Simulated Microgravity and Radiation, Megumi Hada; Sakuya Yamanouchi; Jian Hua Mao; Hiroko Ikeda; Ianik Plante; Premkumar Saganti; Akihisa Takahashi, 2021 American Society for Gravitational and Space Research, 03 Nov. 2021, 03 Nov. 2021, 06 Nov. 2021, English
• Radiation protection effect of Synthetic hibernation following Carbon ion irradiation, Anggraeini Puspitasari; Fabio Squarcio; Matteo Cerri; Akihisa Takahashi; Kenji Hanamura; Yukari Yoshida; Tomoko Yakou; Tomoaki Shirao; Palma Simoniello; Cristina Totis; Julius Oppermann; Walter Tinganelli; Marco Durante, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, 03 Oct. 2021, 06 Oct. 2021, English
• Biological effects of proton and carbon ions dual exposure in human fibroblasts, Hada M; Oizumi T; Nakamura A.J; Hirayama R; Takahashi A; Saganti P, Radiation Research Society's 67th Annual Meeting, 03 Oct. 2021, English
• The increases of chromosome aberration in human peripheral blood lymphocytes exposed to simulated microgravity and radiation simultaneously, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, 第68回北関東医学会総会, 30 Sep. 2021, English
• Depression of bone density at the weight-bearing joints in Wistar Hannover rats by a simulated mechanical stress associated with a partial gravity environment, Shenke Zhang; Daishin Ueno; Takashi Ohira; Hisashi Kato; Tetsuya Izawa; Sakuya Yamanouchi; Yukari Yoshida; Akihisa Takahashi; Yoshinobu Ohira, 第68回北関東医学会総会, 30 Sep. 2021, English
• 冬眠による宇宙放射線防護効果, 髙橋 昭久, 日本宇宙生物科学会第35回大会, 24 Sep. 2021, 24 Sep. 2021, 26 Sep. 2021, Japanese
• The simultaneous exposure to radiation and simulated microgravity increases chromosome aberration in human peripheral blood lymphocytes, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, 日本宇宙生物科学会第35回大会, 25 Sep. 2021, Japanese
• Recent findings on the relative biological effectiveness (RBE) for deterministic effects, Hiroshi YASUDA; Yukari YOSHIDA; Bing WANG; Kento NAGATA; Arifumi HASEGAWA; Akihisa TAKAHASHI, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, Japanese
• Chromosome aberrations in human peripheral blood lymphocytes exposed simultaneously to radiation and simulated microgravity, Sakuya Yamanouchi; Takuya Adachi; Yukari Yoshida; Jordan Rhone; Jian-Hua Mao; Keigi Fujiwara; Premkumar B. Saganti; Akihisa Takahashi; Megumi Hada, The Japanese Radiation Research Society 64th meeting, 22 Sep. 2021, 22 Sep. 2021, 24 Sep. 2021, English
• Synthetic hibernation and radioprotection, A. Puspitasari; M. Cerri; T. Hitrec; F. Squarcio; P. Simoniello; C. Totis; J. Oppermann; A. Takahashi; K. Hanamura; Y. Yoshida; T. Yakou; T. Shirao; M. Durante; W. Tinganelli, Italian Society for Radiation Research, 10 Sep. 2021, English
• マウス悪性黒色腫に対するX線および炭素イオン線照射の局所制御効果とサイトカイン発現量との関連, 吉田由香里; 脇畑庄人; 石川仁; 高橋昭久; 櫻井英幸, 第58回生物部会学術大会, 04 Jun. 2021, Japanese
• X線照射後の代償性肝肥大, 安達拓也; 吉田由香里; 八高知子; 渋谷圭; 髙橋昭久, 第58回群馬放射線腫瘍研究会, 06 Feb. 2021, 06 Feb. 2021, 06 Feb. 2021, Japanese
• Increased chromosome aberrations in human cells exposed simultaneously to simulated microgravity and radiationIncreased chromosome aberrations in human cells exposed simultaneously to simulated microg, Megumi Hada; Sakuya Yamanouchi; Jordan Rhone; Jian-Hua Mao; Hiroko Ikeda; Ianik Plante; Keigi Fujiwara; Premkumar Saganti; Akihisa Takahashi, NASA HRP-IWS, 03 Feb. 2021, English
• Combined effects of radiation and simulated microgravity on decreased locomotor activity in the normal mouse brain, Yukari Yoshida; David Fernandez-Quezada; Sonia Luquin; de Anda; Akihisa Takahashi; Araceli Espinosa-Jeffrey, 43rd COSPAR, 02 Feb. 2021, English
• Dose cancer progress in space?, Akihisa Takahashi, 43rd COSPAR, 02 Feb. 2021, English
• Research on Combined Effects of Space Radiation and Variable Gravity – 2020 Annual Report-, TAKAHASHI Akihisa; SUZUKI Kenshi; TSURUOKA Chizuru; MORIOKA Takamistu; TAKESHIMA Tsuguhide; YOSHIDA Yukari; NAKAMURA Asako; IKEDA Hiroko; HADA Megumi; NAGAMATSU Aiko; OHIRA Yoshinobu; INATOMI Yuko; KAKINUMA Shizuko, 第 35 回 宇宙環境利用シンポジウム, 19 Jan. 2021, Japanese

Awards

• One of the Most Valued Reviewers from 2021 (LSSR), Akihisa Takahashi, One of the Most Valued Reviewers from 2021 (LSSR), Elsevier, Mar. 2022, Official journal
• 2002
• 1980
• Young Investigator Award from Japanese Association of Space Biology Science, 1998
• Incentive Award from Japanese Association of Radiation Research Society, 2001
• Young Investigator Award from International Association for the Sensitization of Cancer Treatment, 2000
• Young Investigator Award from Radiation Effects Association, 2008
• ICRR2015 Excellent Poster Award, 2015
• Association Award, International Association for the Sensitization of Cancer Treatment, 2009
• Abe Award, Japanese Society of Thermal Medicine, 2009
• 2013
• 2013
• Excellent Award of the 41st Japan Health & Research Institute, 2016
• Scientific Dream Award of The 6th International Society of Radiation Neurobiology Conference, 2016
• The Prize of The Japanese Society for Biological Sciences in, 2016
• 2005
• 2005
• 2010
• One of the Most Valued Reviewers from 2019 (LSSR), Akihisa Takahashi, Elsevier, Aug. 2020

Research Projects

• Cancer progression under microgravity environment in space, Akihisa Takahashi, Japan Space Forum, 01 Apr. 2019, 31 Mar. 2022
• Combined effects of simulated microgravity and space radiation on human cells, Prairie View A & M University, Researcher, 28 Jul. 2017, 28 Jul. 2022, Principal investigator
• 06 Sep. 2017, 31 Mar. 2022, Principal investigator
• 07 Jul. 2017, 31 Mar. 2023, Principal investigator
• 05 Sep. 2019, 31 Mar. 2022, Principal investigator
• 2015, 2019, Competitive research funding

  対象リソースIRI
• Acute Effects of Space Radiation with Different Radiation Qualities and Dose-rates, 髙橋昭久; 重粒子線医学推進機構, 新学術領域研究(研究領域提案型), 2015, 2019, Principal investigator, Competitive research funding

  対象リソースIRI
• Apr. 2019, Mar. 2025, Principal investigator, Competitive research funding

  対象リソースIRI
• Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2019, Mar. 2022, Principal investigator, Competitive research funding
• 2017, 2019, Competitive research funding
• 2016, 2018, Principal investigator, Competitive research funding
• Apr. 2019, Mar. 2022, Principal investigator, Competitive research funding
• 2000, 2004, Competitive research funding
• Elucidation of cancer invasion / metastasis mechanism associated with abnormal glucose metabolism and activation of EMT signaling in head and neck cancer, 太田 一郎; 奈; 医学部, 基盤研究(C), 2014, 2016, Competitive research funding
• Selection of DSBs repair pathways in heat-induced cell death mediated by BRCA2, 梶原 淳久; 奈; 医学部; 研究員, 基盤研究(C), 2014, 2016, Competitive research funding
• Elucidation of the suppression mechanism to activation of cancer stem cells by hyperthermia, 高橋 昭久; 先端科学研究指導者育成ユニット, 基盤研究(B), 2011, 2013, Competitive research funding
• Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer, 太田 一郎; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(C), Grant-in-Aid for Scientific Research (C), Nara Medical University, 2011, 2013, In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer., Competitive research funding, 23592537

  対象リソースIRI
• Elucidation of the radio-sensitization mechanism by heat, 高橋 昭久; 先端科学研究指導者育成ユニッ ト, Japan Society for the Promotion of Science, 挑戦的萌芽研究, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 2010, 2012, We already proposed the formation of DNA double-strand breaks (DSBs) by heat-treatment. Here we found that the HR-deficient cells were sensitive, and were low efficiency of DSB repair by heat when compared to the NHEJ-deficient cells and their parental cells. In addition, we demonstrated that heat-induced DSBs were repaired by HR. Our novel findings suggest that the HR exerts an importantrole in the radio-sensitization mechanism by heat., Competitive research funding, 22659224

  対象リソースIRI
• Mechanism of Radioadaptation, 大西 武雄; 奈; 医学部; 特任教授, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2009, 2011, The aim of this study was to examine biological effects of nitric oxide(NO) on radioadaptation such as the induction of radioresistance and the depression of chromosomal aberration from the cell cycle phase and p53 gene status in human cancer cells. This radioadaptation effect was observed during a clearly shortened G_2/M phase and a slightly prolonged S phase. By pre-irradiation with low dose or mild-heat treatment, we found that water-immersion stress(RWIS)-induced stomach ulcer and apoptosis in stomach cells were depressed though the induction of heat shock proteins. To clarify the biological effects of space environment, especially space radiations, a space experiment of "Rad Gene" was performed as the first life experiment with two human lymphoblastoid cell lines bearing wild-type p53 gene(wtp53) and mutated p53 gene mp53 in an International Space Station(ISS) for 133 days. The space flown cells at frozen state were cultured and then exposed to challenging X-ray-irradiation. All of the radioadaptive responses of cell killing, apoptosis, chromosomal aberrations and mutations were found only in wtp53 cells, but not in the mp53 cells., Competitive research funding, 21310040

  対象リソースIRI
• 2009, 2010, Competitive research funding
• Analysis of cell nuclear dynamics in thermotolerance development, 高橋 昭久; 先端科学研究指導者育成ユニット, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2008, 2010, After heat treatment at 45.5℃ for 20 min, DNA DSB recognizing proteins were partially localized with γH2AX foci. Here we show that there were slight differences in the localization pattern among these proteins, such as a disappearance from the nucleus (phospho-ATM) and translocation to the cytoplasm (phospho-NBS1) at 30 min after heat treatment, and some foci (phospho- DNA-PKcs and phospho-Chk2) appeared at 8 h after heat treatment. In addition, we demonstrated that not NHEJ deficient cells but HR deficient cells is heat-sensitivity compared with these proficient cells. Polβ functions as a critical elements involved in thermotolerance. Moreover, we indicated that heat-induced foci of γH2AX and these DNA DSB recognizing proteins were suppressed in thermotolerance development., Competitive research funding, 20390330

  対象リソースIRI
• Effect of mTOR inhibitors on radiation sensitivity of head and neck cancer cells, 太田 一郎; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(C), Grant-in-Aid for Scientific Research (C), Nara Medical University, 2008, 2010, A high extent of activation of the PI3K/Akt pathway is involved in head and neck cancer therapeutic resistance, including radiotherapy and chemotherapy. The aim of this study was to examine whether the effect of rapamycin, an inhibitor of mTOR, on chemo- and radio-sensitivity is affected in human head and neck cancer cells. Rapamycin could enhance the effect of radiation and cisplatin through the repression of pro-survival signals, including PI3K/Akt pathway, and the reduction in the apoptotic threshold., Competitive research funding, 20592025

  対象リソースIRI
• A study of the Heavy-ion beams medical treatment on the oral cancer, 桐田 忠昭; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2006, 2008, Competitive research funding, 18390546

  対象リソースIRI
• 2006, 2007, Competitive research funding
• To clarify of the mechanism of thermotolerance, 高橋 昭久; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Nara Medical University, 2006, 2007, Although heat shock proteins (HSPs) are well known to contribute to thermotolerance, they only play a supporting role in the phenomenon. Recently, it has been reported that heat sensitivity depends on heat-induced DNA double-strand breaks (DSBs), and thermotolerance also depends on the suppression of DSB formation. However the critical elements involved in thermotolerance have not yet been fully identified. Heat produces DSBs and leads to cell death through denaturation and dysfunction of heat-labile repair proteins such as DNA polymerase β (Polβ). Here we show that thermotolerance was partially suppressed in Polβ-/- mouse embryonic fibroblasts (MEFs) when compared to the wild type MEFs, and was also suppressed in the presence of the HSP inhibitor, KNK437, in both cell lines. Moreover, we found that heat-induced γH2AX was suppressed in the thermotolerant cells. These results suggest that Polβ at least contributes to thermotolerance through its reactivation and stimulation by Hsp27 and Hsp70. In addition, it appears possible that fewer DSBs were formed after a challenging heat exposure because pre-heat-induced Hsp27 and Hsp70 can rescue or restore other, as yet unidentified, heat-labile proteins besides Polβ. Our novel findings provide strong evidence that Polβ functions as a critical element involved in thermotolerance and exerts an important role in heat-induced DSBs., Competitive research funding, 18390335

  対象リソースIRI
• Regulation of radiation-induced apoptosis targeting signal transduction factors, 大西 武雄; 奈; 医学部, Japan Society for the Promotion of Science, 基盤研究(A), Grant-in-Aid for Scientific Research (A), Nara Medical University, 2005, 2007, To develop more efficient regimens for various malignant tumors the attention has focused on searching for substances to sensitize cell lethality of tumors by radiation. Inhibitors against anti-apoptosis and/or cellular Proliferation signal transductions are as good candidates for enhancers of radiation Sensitivity on human cancer calls This study examined whether siRNAs or chemical inhibitors targeting key factors (NBS1, XIAP, P13-K, MAPK, Akt and heat proteins) in DNA repair and survival Signal transductions for anti-apoptosis and/or cellular, proliferation after radiation enhance radiation induced apoptosis, Further, it was examined whether; heavy-ion bin effectively, induce apoptosis p53 independently. We analyzed radiation/heat sensitivity apoptosis with colony formation assay, Western blot, fluorescent immuno-cytochemistry, arid hoechst staining using wild-type p53 or mutated p53 gene-transfected human lung and tongue cancer cells. We showed siRNAs targeting NBS1 and XIAP enhanced radiation sensitivity more efficiently in mutated p53 cells than the wild-type p53 cell Furthermore, LY294002 (inhibitor of PI3-K) enhanced radiation/heat sensitivity and radiation/heat-induced apoptosis p53 independently. PD98059 (inhibitor of MEK) and-SB203580 (inhibitor of p38) enhanced heat sensitivity but not radiation Sensitivity, Heavy-ion beams induced p53 independent apoptosis. Our results suggest that these siRNAs, chemical inhibitors and heavy-ion beams might contribute to high curative efficiency in radiation/heat cancer therapy for malignant cancer leading to enhanced, p53 independent radiation/heat sensitivity., Competitive research funding, 17201015

  対象リソースIRI
• 2004, 2005, Competitive research funding
• Low dose-rate effects and non-homologous end-joining repair pathway of double strand breaks, 内海 博司; 体質研究会; 主任研究員, Japan Society for the Promotion of Science, 基盤研究(B), Grant-in-Aid for Scientific Research (B), Health Research Foundation, 2004, 2006, Introduction : In general, the dose rate of sparsely ionizing radiation is reduced over a period of time the biological effect of a given total dose is reduced. This low dose-rate effects (LDRE) has been generally accepted to result from the sub-lethal damage (SLD) recovery. To study the molecular mechanism of LDRE, we analyzed the knock-out mutants KU70^<-/->, RAD54^<-/->, and KU70^<-/->/RAD541^<-/->of the chicken B-cell line, DT40 (Cell (1997) 89:185-193,EMBO J (1998) 17:5497-5508), since our recent studies on SLD recovery, using these DT40 cells showed that the recovery of SLD is due to DSB repair mediated by homologous recombination (HR) (Radiat.Res (2001) 155,680-686). Materials and Methods : Our results were obtained with these knockout mutant clones of DT40. The length of cell cycle is almost the same,〜8 h, between the four types of cells. LDR radiation was delivered at under 1Gy/day using a ^<137>Cs g-ray source (Sangyo Kagaku Co., Ltd., Tokyo) at the RBC, Kyoto University. Cells were irradiated in suspension continuously at 39.5℃ in an incubator set in front of the ^<137>Cs source. Subsequently, serially diluted cells were inoculated into several individual culture dishes (Iwaki, Japan) containing 6 ml of 1.5% (w/v) methylcellulose (Aldrich, Milwaukee, WI) containing D-MEM/F-12 (Gibco-BRL), 15% FCS, 1.5% chicken serum and 10mM b-mercaptoethanol for each radiation dose. The cells were allowed to grow for 7 days. Results and Discussions : Survival enhancement by LDR irradiation was observed in parent DT40 and RAD54^<-/-> cells but not in non-homologous end-joining (NHEJ) deficient KU70^<-/-> and KU70^<-/->/RAD54^<-/-> cells. Under continuous LDR irradiation, NHEJ-deficient cells will be irradiated in G1 phase and killed since there is no repair system of DSBs in G1 phase. In LDRE, NHEJ pathway shall be more important than HR pathway because NHEJ pathway is working in whole cell cycle. We studied further LDRE using the deficient KU70^<-/-> and KU70^<-/->/53BP1^<-/-> cells since 53BP1 is reported to play a role in new NHEJ repair (Genes to Cells (2006) 11:935-948). KU70^<-/->/53BP1^<-/-> cells were sensitive than KU70^<-/-> cells under 1 Gy/day dose rate irradiation. These results suggest that 53BP1 play a role in a pathway distinct form Ku-dependent NHEJ pathways, and that both NHEJ pathway is important for LDRE., Competitive research funding, 16310040

  対象リソースIRI
• 2002, 2003, Competitive research funding
• 2000, 2001, Competitive research funding
• 2011, 2015, Competitive research funding
• Elucidation of molecular mechanisms for radiation-induced cellular responses, JST Target Oriented Research for Embryonic Science and Technology (TOREST), 2011, 2015, Competitive research funding
• Biological effect of space radiation, Grant-in-Aid for Scientific Research, 2015, Competitive research funding
• 26 Mar. 2018, 31 Mar. 2022, Principal investigator
• 01 Apr. 2019, 31 Mar. 2022, Principal investigator
• 01 Apr. 2017, 31 Mar. 2018, Principal investigator
• Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2021, Mar. 2022, Principal investigator, Competitive research funding
• Combined effects of space radiation and variable gravity, TAKAHASHI Akihisa, Oct. 2020, Mar. 2021, Principal investigator, Competitive research funding
• 01 Apr. 2022, 31 Mar. 2025, 23K24402

  対象リソースIRI
• 01 Apr. 2022, 31 Mar. 2025, 22H03143

  対象リソースIRI
• 01 Apr. 2020, 31 Mar. 2023, 20K09718

  対象リソースIRI

Research Grants & Projects

• Akihisa Takahashi
  Gunma University, Gunma University for the Promotion of Scientific Research., 2020, 2020

Educational Activities

Teaching Experience

• Natural Science Exercises / Experiments, Gunma University, May 2020, 9999
• Introduction to Ｍedicine, Teikyo University, Sep. 2020, Sep. 2020
• Introduction to Medical Research, Nara Medical University, Oct. 2019, Oct. 2019