Researcher Profile and Settings

Researcher

• Name

  OHSHIMA Noriyasu

Profile and Settings

• Name

  Ohshima, Noriyasu

Foreign language

• Use in presentation

  English, English

• Use in publication

  English, English

Affiliation

• Gunma University, Assistant Professor

Education

• Apr. 1998, Mar. 2002
• Apr. 1996, Mar. 1998
• Apr. 1992, Mar. 1996, Tohoku University, Faculty of Science, Department of Biology

Degree

• Doctor of philosophy

Association Memberships

• THE JAPANESE BIOCHEMICAL SOCIETY

Research Experience

• Apr. 2008, 9999, Gunma University, graduate school of medicine, biochemstry, assistant professor, Assistant prof lv
• Apr. 2005, Mar. 2008, RIKEN(The Institute of Physical and Chemical Research), Harima Institute, Shiro biometal laboratory, Researcher postdoc lv
• Apr. 2002, Mar. 2005, Researcher postdoc lv

Research Activities

Research Areas

• Life sciences, Medical biochemistry

Research Interests

• lipid mediator
• lipidomics
• mass spectrometry
• glycerophosphodiester phosphodiesterase

Published Papers

• GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice., Aisyah Rahmawati;Ohshima Noriyasu;Watanabe Daiki;Nakagawa Yoshiko;Sakuma Tetsushi;Nitschke Felix;Nakamura Minako;Sato Koji;Nakahata Kaori;Yokoyama Chihiro;Marchioni Charlotte R;Kumrungsee Thanutchaporn;Shimizu Takahiko;Sotomaru Yusuke;Takeo Toru;Nakagata Naomi;Izumi Takashi;Miura Shinji;Minassian Berge A;Yamamoto Takashi;Wada Masanobu;Yanaka Noriyuki, May 2024, Communications biology, 7, 1, Scientific journal

  DOI
• The possibility of ultrasensitive detection of biomolecules using silicon nanowire biosensor with structural optimization, Hui Zhang;Mayuna Abe;Fumiya Osawa;Yawei Qiu;Noriyasu Ohshima;Taira Kajisa;Toshiya Sakata;Takashi Izumi;Hayato Sone, 12 Mar. 2024, Japanese Journal of Applied Physics, 63, 03SP85, International conference proceedings
• Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid, Binderiya Tserendavga, Noriyasu Ohshima, Chiaki Fujita, Koji Yuzawa, Mari Ohshima, Noriyuki Yanaka, Yoji Andrew Minamishima, Takashi Izumi, 15 Sep. 2021, The Journal of Biochemistry, 170, 6, 713, 727, Scientific journal
• Design and Fabrication of Silicon Nanowire-Based Biosensors with Integration of Critical Factors: Toward Ultrasensitive Specific Detection of Biomolecules., Zhang Hui;Kikuchi Naoki;Ohshima Noriyasu;Kajisa Taira;Sakata Toshiya;Izumi Takashi;Sone Hayato, 03 Nov. 2020, ACS applied materials & interfaces, 12, 46, Scientific journal

  DOI
• Simultaneous capillary electrophoresis of anions and cations in a single injection using an anion exchanger-modified capillary for determination of salivary ions in combination with statistical analyses., Mori Masanobu;Aoyagi Keisuke;Tomoda Toshihiro;Ishikawara Fumi;Sakamoto Shou;Myochin Hironori;Kuga Midori;Kozaki Daisuke;Ohshima Noriyasu;Izumi Takashi;Itabashi Hideyuki;Shoho Yoshifumi;Yoshida Akihiro;Tsunekawa Katsuhiko;Kimura Takao;Murakami Masami, 29 Oct. 2020, Journal of chromatography. A, 1635, Scientific journal

  DOI
• CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes., Shimokawa Chikako;Kato Tamotsu;Takeuchi Tadashi;Ohshima Noriyasu;Furuki Takao;Ohtsu Yoshiaki;Suzue Kazutomo;Imai Takashi;Obi Seiji;Olia Alex;Izumi Takashi;Sakurai Minoru;Arakawa Hirokazu;Ohno Hiroshi;Hisaeda Hajime, Apr. 2020, Nature communications, 11, 1, Scientific journal

  DOI
• The role of autonomously secreted PGE2 and its autocrine/paracrine effect on bone matrix mineralization at the different stages of differentiating MC3T3-E1 cells., Suzuki Hiraku;Ohshima Noriyasu;Tatei Kazuaki;Taniguchi Tomoyo;Sato Seiichi;Izumi Takashi, 12 Feb. 2020, Biochemical and biophysical research communications, 524, 4, Scientific journal

  DOI
• Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase., Araki Mari;Ohshima Noriyasu;Aso Chizu;Konishi Akimitsu;Obinata Hideru;Tatei Kazuaki;Izumi Takashi, May 2016, Journal of biochemistry, 160, 5, Scientific journal

  DOI
• New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity., Ohshima Noriyasu;Kudo Takahiro;Yamashita Yosuke;Mariggio Stefania;Araki Mari;Honda Ayako;Nagano Tomomi;Isaji Chiaki;Kato Norihisa;Corda Daniela;Izumi Takashi;Yanaka Noriyuki, Dec. 2014, The Journal of biological chemistry, 290, 7, Scientific journal

  DOI
• Fabrication of Ultrahigh-Sensitivity Silicon Nanowire Biosensor by CMOS-Compatible Process for Detecting Biomolecules at Low Concentrations, Hui Zhang,Kei Okabe,Naoki Kikuchi,Noriyasu Ohshima,Taira Kajisa,Toshiya Sakata,Takashi Izumi,Hayato Sone, Dec. 2019, Proceedings of International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS2019), International conference proceedings
• Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli., Hirakawa Hidetada;Takita Ayako;Sato Yumika;Hiramoto Suguru;Hashimoto Yusuke;Ohshima Noriyasu;Minamishima Yoji A;Murakami Masami;Tomita Haruyoshi, May 2023, Microbiology spectrum, 11, 3, Scientific journal

  DOI
• Fabrication of N-Type Silicon Nanowire Biosensor for Sub-10-Femtomolar Concentration of Immunoglobulin, Tashiro Tomoya,Hui Zhang,Kakeru Oshima,Yuya Sakurai,Takaaki Suzuki,Noriyasu Ohshima,Takashi Izumi,Hayato Sone, Nov. 2018, Key Engineering Materials, 790, 28, 33, Scientific journal

  DOI
• EPR and ENDOR studies of the distal site coordination of shark heart myoglobin, Y. Ohba,S. Yanagiya,N. Ohshima,A. Matsuoka,K. Shikama,S. Yamauchi, 2007, APPLIED MAGNETIC RESONANCE, 31, 3-4, 527, 541, Scientific journal

  DOI
• マウス腹腔マクロファージにおける受容体依存的なPAFの分解, ;;;, May 2001, 43, 99, 102, Scientific journal
• 大腸菌由来細胞質型グリセロホスホジエステルホスホジエステラーゼ(UgpQ)の酵素反応解析, ;;;;, Jun. 2004, 46, 64, 66, Scientific journal
• 表面プラズモン共鳴現象による生細胞におけるGPCRシグナルの検出, ;;;;;, Jul. 2009, 51, 208, 210
• アシルプロテインチオエステラーゼ1/リゾホスホリパーゼ1の活性と細胞内局在, ;;;;;;;, May 2010, 52, 124, 127, Symposium
• 哺乳動物のGDE群とマウスGDE5の非酵素的機構による骨格筋分化制御, ;;;;MARIGGIO Stefania;;;;;;CORDA Daniela;;, Apr. 2011, 53, 208, 209, Symposium
• 新規脳ジアシルグリセロールリパーゼの同定, ;;;;;;;;, May 2013, 55, 118, 120, Symposium
• Receptor-dependent metabolism of platelet-activating factor in murine macrophages., Ohshima Noriyasu;Ishii Satoshi;Izumi Takashi;Shimizu Takao, Jan. 2002, The Journal of biological chemistry, 277, 12, Scientific journal

  DOI
• Crystal structure of purine nucleoside phosphorylase from Thermus thermophilus., Tahirov Tahir H;Inagaki Eiji;Ohshima Noriyasu;Kitao Tomoe;Kuroishi Chizu;Ukita Yoko;Takio Koji;Kobayashi Masanori;Kuramitsu Seiki;Yokoyama Shigeyuki;Miyano Masashi, Apr. 2004, Journal of molecular biology, 337, 5, Scientific journal

  DOI
• Crystallographic structure and biochemical analysis of the Thermus thermophilus osmotically inducible protein C., Rehse Peter H;Ohshima Noriyasu;Nodake Yuichi;Tahirov Tahir H, May 2004, Journal of molecular biology, 338, 5, Scientific journal

  DOI
• Structure of Thermus thermophilus 2-Keto-3-deoxygluconate kinase: evidence for recognition of an open chain substrate., Ohshima Noriyasu;Inagaki Eiji;Yasuike Kiyonori;Takio Koji;Tahirov Tahir H, 2004, Journal of molecular biology, 340, 3, Scientific journal

  DOI
• Structure of aldolase from Thermus thermophilus HB8 showing the contribution of oligomeric state to thermostability., Lokanath Neratur K;Shiromizu Ikuya;Ohshima Noriyasu;Nodake Yuichi;Sugahara Mitsuaki;Yokoyama Shigeyuki;Kuramitsu Seiki;Miyano Masashi;Kunishima Naoki, Sep. 2004, Acta crystallographica. Section D, Biological crystallography, 60, Pt 10, Scientific journal

  DOI
• Crystal structure of novel NADP-dependent 3-hydroxyisobutyrate dehydrogenase from Thermus thermophilus HB8., Lokanath Neratur K;Ohshima Noriyasu;Takio Koji;Shiromizu Ikuya;Kuroishi Chizu;Okazaki Nobuo;Kuramitsu Seiki;Yokoyama Shigeyuki;Miyano Masashi;Kunishima Naoki, 2005, Journal of molecular biology, 352, 4, Scientific journal

  DOI
• Structure of ATP-dependent phosphoenolpyruvate carboxykinase from Thermus thermophilus HB8 showing the structural basis of induced fit and thermostability., Sugahara Michihiro;Ohshima Noriyasu;Ukita Yoko;Sugahara Mitsuaki;Kunishima Naoki, Oct. 2005, Acta crystallographica. Section D, Biological crystallography, 61, Pt 11, Scientific journal

  DOI
• Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase., Inagaki Eiji;Ohshima Noriyasu;Takahashi Hitomi;Kuroishi Chizu;Yokoyama Shigeyuki;Tahirov Tahir H, Jul. 2006, Journal of molecular biology, 362, 3, Scientific journal

  DOI
• New insights into the binding mode of coenzymes: structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase complexed with NADP+., Inagaki Eiji;Ohshima Noriyasu;Sakamoto Keiko;Babayeva Nigar D;Kato Hiroaki;Yokoyama Shigeyuki;Tahirov Tahir H, May 2007, Acta crystallographica. Section F, Structural biology and crystallization communications, 63, Pt 6, Scientific journal

  DOI
• Escherichia coli cytosolic glycerophosphodiester phosphodiesterase (UgpQ) requires Mg2+, Co2+, or Mn2+ for its enzyme activity., Ohshima Noriyasu;Yamashita Saori;Takahashi Naoko;Kuroishi Chizu;Shiro Yoshitsugu;Takio Koji, Dec. 2007, Journal of bacteriology, 190, 4, Scientific journal

  DOI
• Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1., Hirano Tohko;Kishi Mikiko;Sugimoto Hiroyuki;Taguchi Ryo;Obinata Hideru;Ohshima Noriyasu;Tatei Kazuaki;Izumi Takashi, May 2009, Biochimica et biophysica acta, 1791, 8, Scientific journal

  DOI
• グリセロホスホジエステラーゼの分子進化から生理的役割の新たな展開　哺乳動物における新基質の発見, ;;, May 2016, 54, 6, 387, Scientific journal
• 可溶性2-アラキドノイルグリセロール産生酵素、DDHD2の酵素学的解析, ;;;;;;, May 2016, 58, 176, Scientific journal
• 膜貫通型リゾホスホリパーゼD、GDE4過剰発現細胞における脂質の網羅的解析, ;;;;;;, Dec. 2017, 2017年度, [2P, Symposium
• 骨芽細胞様細胞MC3T3-E1における分化段階に応じた機械的刺激による骨形成制御応答の解析, ;;;;;, Dec. 2017, 2017年度, [2P, Symposium
• 周産期甲状腺機能低下症マウスにて、エンドカンナビノイド系が小脳発生異常に影響を与える(Endocannabinoid System is responsible for cerebellum development abnormality in perinatal hypothyroid mice), ;;;;;, Aug. 2020, 96, 1, 292, Symposium
• キャピラリー電気泳動を用いる唾液中の陰及び陽イオンの同時分析と生理活性物質との相関, ;;;;;;;;;;;;, Aug. 2019, 68年会, 334, Symposium
• マウス由来GDE7は環状ホスファチジン酸を産生する酵素活性を有する, ;;;;;;;, May 2022, 64, 247, Symposium
• A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism., Okazaki Yuri;Ohshima Noriyasu;Yoshizawa Ikumi;Kamei Yasutomi;Mariggio Stefania;Okamoto Keiko;Maeda Masahiro;Nogusa Yoshihito;Fujioka Yuichiro;Izumi Takashi;Ogawa Yoshihiro;Shiro Yoshitsugu;Wada Masanobu;Kato Norihisa;Corda Daniela;Yanaka Noriyuki, Jun. 2010, The Journal of biological chemistry, 285, 36, Scientific journal

  DOI
• [Oxidized free fatty acids as lipid mediators and functions of G2A as their receptor]., Kishimoto Koji;Obinata Hideru;Kishi Mikiko;Ohshima Noriyasu;Tatei Kazuaki;Izumi Takashi, 2011, Seikagaku. The Journal of Japanese Biochemical Society, 83, 6, Scientific journal
• The emerging physiological roles of the glycerophosphodiesterase family., Corda Daniela;Mosca Maria G;Ohshima Noriyasu;Grauso Laura;Yanaka Noriyuki;Mariggio Stefania, Jan. 2014, The FEBS journal, 281, 4, Scientific journal

  DOI
• Combination of postmortem mass spectrometry imaging and genetic analysis reveals very long-chain acyl-CoA dehydrogenase deficiency in a case of infant death with liver steatosis., Takahashi Yoichiro;Sano Rie;Nakajima Tamiko;Kominato Yoshihiko;Kubo Rieko;Takahashi Keiko;Ohshima Noriyasu;Hirano Tohko;Kobayashi Susumu;Shimada Takehiro;Tokue Hiroyuki;Awata Sachiko;Hirasawa Satoshi;Ishige Takashi, Sep. 2014, Forensic science international, 244, Scientific journal

  DOI
• Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type., Yoshiyama Shinji;Chen Zhenyi;Okagaki Tsuyoshi;Kohama Kazuhiro;Nasu-Kawaharada Ritsuko;Izumi Takashi;Ohshima Noriyasu;Nagai Takeharu;Nakamura Akio, Oct. 2014, Atherosclerosis, 237, 2, Scientific journal

  DOI
• Protein purification and cloning of diacylglycerol lipase from rat brain., Aso Chizu;Araki Mari;Ohshima Noriyasu;Tatei Kazuaki;Hirano Tohko;Obinata Hideru;Kishi Mikiko;Kishimoto Koji;Konishi Akimitsu;Goto Fumio;Sugimoto Hiroyuki;Izumi Takashi, Jan. 2016, Journal of biochemistry, 159, 6, Scientific journal

  DOI
• GDE5 inhibition accumulates intracellular glycerophosphocholine and suppresses adipogenesis at a mitotic clonal expansion stage., Okazaki Yuri;Nakamura Keishi;Takeda Shuto;Yoshizawa Ikumi;Yoshida Fumiyo;Ohshima Noriyasu;Izumi Takashi;Klein Janet D;Kumrungsee Thanutchaporn;Sands Jeff M;Yanaka Noriyuki, Nov. 2018, American journal of physiology. Cell physiology, 316, 2, Scientific journal

  DOI
• Regulation of MC3T3-E1 differentiation by actin cytoskeleton through lipid mediators reflecting the cell differentiation stage., Suzuki Hiraku;Tatei Kazuaki;Ohshima Noriyasu;Sato Seiichi;Izumi Takashi, Apr. 2019, Biochemical and biophysical research communications, 514, 2, Scientific journal

  DOI
• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice., Kasano-Camones Carlos Ichiro;Takizawa Masayuki;Ohshima Noriyasu;Saito Chinatsu;Iwasaki Wakana;Nakagawa Yuko;Fujitani Yoshio;Yoshida Ryo;Saito Yoshifumi;Izumi Takashi;Terawaki Shin-Ichi;Sakaguchi Masakiyo;Gonzalez Frank J;Inoue Yusuke, 26 Apr. 2023, Journal of biochemistry, 173, 5, Scientific journal

  DOI
• Estimation of the Depletion Layer Thickness in Silicon Nanowire-Based Biosensors from Attomolar-Level Biomolecular Detection., Zhang Hui;Qiu Yawei;Osawa Fumiya;Itabashi Meiko;Ohshima Noriyasu;Kajisa Taira;Sakata Toshiya;Izumi Takashi;Sone Hayato, Apr. 2023, ACS applied materials & interfaces, 15, 16, Scientific journal

  DOI
• Capillary electrophoresis using triple layer modified capillary facilitating salivary ion analyses: Application to search for potential stress markers induced by cold pressure test., Myochin Hironori;Ohshima Noriyasu;Izumi Takashi;Hisajima Tatsuya;Chaleckis Romanas;Mori Masanobu, Feb. 2024, Journal of chromatography. A, 1720, Scientific journal

  DOI
• Murine GDE4 and GDE7 produce lysophosphatidic acid and/or cyclic phosphatidic acid, ;;;;;;;, Nov. 2021, 94回, [P, Symposium
• choline化合物摂取時のtrimethylamine-N-oxide産生におけるGDE5の機能的関与, ;;;;;;;;;, Mar. 2023, 77回, 230, Symposium
• PPARα活性化は肝特異的Hnf4a欠損マウスのNAFLD発症を部分的に促進する(PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice), ;;;;;;;;;;;;;, May 2023, 173, 5, 393, Scientific journal
• 骨格筋におけるリン脂質代謝酵素GDE5/Gpcpd1の欠損はDHA結合型膜リン脂質を減少させ、筋収縮力を低下させる, ;;;;;;;;;;;;;, Apr. 2024, 78回, 271, Symposium
• choline供給酵素GDE5の肝臓特異的欠損マウスの作製、および形質の解析, ;;;;;;;;, Apr. 2020, 94, 4, 273
• 選択ワークショップ5:抗菌性物質・薬剤耐性　AckAとPta,Fisの機能欠失による大腸菌のホスホマイシン耐性化機構, ;;;;;;;;, Jun. 2024, 79, 2, 71, Symposium
• Role of Gpcpd1 in intestinal alpha-glycerophosphocholine metabolism and trimethylamine N-oxide production., Chen Siyi;Inui Shiho;Aisyah Rahmawati;Nakashima Ryoko;Kawaguchi Tatsuya;Hinomoto Minori;Nakagawa Yoshiko;Sakuma Tetsushi;Sotomaru Yusuke;Ohshima Noriyasu;Kumrungsee Thanutchaporn;Ohkubo Takeshi;Yamamoto Takashi;Miura Yutaka;Suzuki Takuya;Yanaka Noriyuki, Nov. 2024, The Journal of biological chemistry, 300, 12, Scientific journal

  DOI
• Ultrasensitive Specific Detection of Anti-influenza A H1N1 Hemagglutinin Monoclonal Antibody Using Silicon Nanowire Field Effect Biosensors., Zhang Hui;Osawa Fumiya;Okamoto Haru;Qiu Yawei;Liu Zhiheng;Ohshima Noriyasu;Kajisa Taira;Sakata Toshiya;Izumi Takashi;Sone Hayato, Jan. 2025, ACS applied bio materials, 8, 2, Scientific journal

  DOI
• 家庭環境内における重金属類曝露シナリオの解明　調査方法の確立, ;;;;;;;;;, Feb. 2019, 74, Suppl., S144

MISC

• Fabrication of High-Sensitivity Silicon Nanowire Biosensor by Electron Beam Lithography and Detection of Antigen-Antibody Specific Binding at Attomolar Concentration, 張慧,大嶋紀安,大嶋駆,菊池直樹,加治佐平,坂田利弥,和泉孝志,曾根逸人, Mar. 2019, 9a-S421-12, Summary national conference
• Novel function of 9(S)-hydroxyoctadecadienoic cid on proliferation of T cells, Melisa I. Baarliana,Kishi M,Obinata H,Ogawa A,Kishimoto K,Ohshima N,Tatei K,Izumi T, 2010, 52, 212, 215
• 表面プラズモン共鳴現象による生細胞におけるGPCRシグナルの検出, 陳可欣,大日方英,岸美紀子,大嶋紀安,立井一明,和泉孝志, 2009, 51, 208, 210
• 新規因子GDE5の筋芽細胞分化における役割、および骨格筋特異的GDE5過剰発現マウスの形質の解析, 吉澤郁美,岡本佳子,前田将宏,岡崎優利,大嶋紀安,和泉孝志,加藤範久,矢中規之, Mar. 2009, 日本農芸化学会2009年度大会 大会講演要旨集, 145, 145
• ほ乳類グリセロホスホジエステルホスホジエステラーゼの酵素学的解析, 大嶋紀安,金子真弓,瀧尾擴士,城宜嗣,岸美紀子,立井一明,和泉孝志, Nov. 2009, 群馬大学・秋田大学連携 第３回グローバルCOE若手研究者シンポジウム 抄録集, 5, 5
• Characterization of mouse glycerophosphodiester phosphodiesterase 1 (GDE1), Ohshima N,Kaneko M,Takahashi N,Takio K,Shiro Y,Tatei T,Izumi T, 2009, 4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009) Abstract
• マウス由来グリセロホスホジエステルホスホジエステラーゼ１(GDE1)の酵素学的解析, 大嶋紀安,金子真弓,瀧尾擴士,城宜嗣,和泉孝志, 2008, 平成20年 日本生化学会関東支部例会 プログラム・講演要旨集
• マウス由来グリセロホスホジエステルホスホジエステラーゼ１(GDE1)の酵素学的解析, 大嶋紀安,高橋直子,瀧尾擴士,城宜嗣, 2007, 80回・30回
• 大腸菌由来細胞質型グリセロホスホジエステルホスホジエステラーゼ (UgpQ)の酵素反応解析, 大嶋紀安,山下さおり,前川圭美,黒石千寿,瀧尾擴士, 2004, 脂質生化学研究, 46, 64, 66
• Receptor-Dependent Metabolism of PAF by Macrophages, Ohshima N,Ishii S,Izumi T,Shimizu T, 2001, Seventh International Congress on Platelet-Activating Factor and Lipid Mediators Abstract
• マウスマクロファージにおける受容体依存的なPAFの分解, 大嶋紀安,石井聡,和泉孝志,清水孝雄, 2001, 脂質生化学研究, 43, 99, 102
• マクロファージにおけるPAF受容体依存的なPAF分解, 大嶋 紀安,石井 聡,和泉 孝志,清水 孝雄, Aug. 2001, 生化学, 73, 8, 1013, 1013
• Structure and Function of Thermus thermophilus 2-keto-3-deoxygluconate kinase, Ohshima N,Inagaki E,Kajihara Y,Yasuike K,Takio K,Tahirov TH, 2004, The 1st Pacific-Rim International Conference on Protein Science (The 4th Annual Meeting of the Protein Science Society of Japan) Abstracts, 189, 189
• Crystallographic and Kinetic Analysis of the Osmotically Inducible Protein C from Thermus Thermophilis HB8, Rehse PH,Oshima N,Nodake Y,Tahirov TH, 2004, The 1st Pacific-Rim International Conference on Protein Science (The 4th Annual Meeting of the Protein Science Society of Japan) Abstracts, 188, 188
• 哺乳動物のGDE群とマウスGDE5の非酵素的機構による骨格筋分化制御, Noriyasu Ohshima,Takashi Izumi, Aug. 2011, 群馬大学・秋田大学連携 第５回グローバルCOE若手研究者シンポジウム 抄録集, 53, 208, 209
• アシルプロテインチオエステラーゼ1/リゾホスホリパーゼ1の活性と細胞内局在, 平野瞳子,岸美紀子,杉本博之,田口良,大日方英,大嶋紀安,立井一明,和泉孝志, 2010, 52, 124, 127
• 新規脳ジアシルグリセロールリパーゼの同定, 荒木 麻理,麻生 知寿,大嶋 紀安,立井 一明,平野 瞳子,杉本 博之,岸 美紀子,岸本 幸治,和泉 孝志, 2013, 55, 118, 120
• 新規リゾホスファチジン酸産生酵素、GDE4およびGDE7の酵素学的解析, 大嶋 紀安,工藤 尊裕,山下 洋介,荒木 麻理,伊佐治 千明,本田 絢子,長野 友美,立井 一明,加藤 範久,矢中 規之,和泉 孝志, 2015, 57, 95, 96
• 可溶性2-アラキドノイルグリセロール産生酵素、DDHD2の酵素学的解析, 荒木麻理,大嶋紀安,麻生知寿,小西昭充,大日方英,立井一明,和泉孝志, 2016, 58, 176, 177
• 電子線リソグラフを用いた超高感度Siナノワイヤバイオセンサの創製, 曾根 逸人,櫻井 祐也,田代 朋也,大嶋 紀安,和泉 孝志, 2017, 群馬大学 医理工生命医科学融合医療イノベーションプロジェクト年次報告書 Annual Report 2017, 75, 75
• 骨芽細胞様細胞MC3T3-E1における分化段階に応じた機械的刺激による骨形成制御応答の解析, 鈴木 啓,大嶋 紀安,小西 昭充,立井 一明,佐藤 精一,和泉 孝志, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, 2P-0735
• 膜貫通型リゾホスホリパーゼD、GDE4過剰発現細胞における脂質の網羅的解析, 大嶋 紀安,荒木 麻理,大日方 英,小西 昭充,鈴木 啓,立井 一明,和泉 孝志, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, 2P-0027
• 電子線リソグラフィを用いたSiナノワイヤバイオセンサの作製と低濃度抗体検出, 田代朋也,大嶋駆,櫻井裕也,ZHANG Hui,鈴木孝明,大嶋紀安,和泉孝志,曾根逸人, Oct. 2017, 電気学会バイオ・マイクロシステム研究会資料, BMS-17-49, 11, 16
• 新規酵素GDE4およびGDE7は,LPCおよびlysoPAFを分解し,LPAおよびalkyl‐LPAの産生に関与する, 工藤尊裕,大嶋紀安,山下洋祐,MARIGGIO Stefania,加藤範久,CORDA Daniela,和泉孝志,矢中規之, Jan. 2015, 日本農芸化学会中四国支部第41回講演会講演要旨集(Web), 41st, 47, 47
• Identification and functional analyses of a novel diacylglycerol lipase from rat brain, Chiaki Isaji,Takahiro Kudo,Noriyasu Ohshima,Yosuke Yamashita,Mari Araki,Ayako Honda,Tomomi Nagano,Norihisa Kato,Akiyoshi Konishi,Koji Kishimoto,Kazuaki Tatei,Noriyuki Yanaka,Takashi Izumi, 2015, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015) Abstract, 239, 239
• GDE4 and GDE7 Produce Lysophosphatidic Acid by Lysophospholipase D Activity, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Takashi Izumi, 2015, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015) Abstract, 238, 238
• Purification and characterization of a soluble diacylglycerol lipase from rat brain, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Hideru Obinata,Takashi Izumi, 2015, 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, 136, 136
• ラット脳ジアシルグリセロールリパーゼの精製と機能解析, 大嶋紀安,荒木麻理,麻生千寿,立井一明,岸本幸治,和泉孝志, Aug. 2014, 群馬大学・秋田大学 連携 第3回 生体情報研究シンポジウム, 6, 6
• Gタンパク質共役型受容体、G2Aはヒトアストロサイトーマ細胞株のがん幹細胞性を制御する, 岸本幸治,原口崇,清水健志,山口藍子,吉原利忠,大嶋紀安,立井一明,飛田成史,飯田靖彦,対馬義人,和泉孝志, Sep. 2013, 平成25年度 日本生化学会関東支部例会 プログラム・講演要旨集, 86回, 1T10a-05
• 新規ラット脳ジアシルグリセロールリパーゼの同定, 荒木 麻理,麻生 知寿,大嶋 紀安,立井 一明,平野 瞳子,杉本 博之,岸 美紀子,岸本 幸治,和泉 孝志, Sep. 2013, 日本生化学会大会プログラム・講演要旨集, 86回, 1P-067
• 新規酵素GDE7はオートタキシン活性を有し，LPAおよびalkyl-LPAの産生に関与する, 工藤 尊裕,大嶋 紀安,Stefania Mariggio,本田 絢子,長野 友美,加藤 範久,Daniela Corda,和泉 孝志,矢中 規之, Mar. 2013, 日本農芸化学会2013年度仙台大会 大会プログラム集・大会講演要旨集, 3A41p14
• 9-HODE-activated GPCR, G2A induces epithelial-to-mesenchymal transition of human astrocytoma cells prior to generation of stem cell-like properties., Kishimoto K,Haraguchi T,Shimizu K,Yamaguchi A,Yoshihara T,Ohshima N,Tatei K,Tobita S,Tsushima Y,Izumi T, Nov. 2013, Society of Neuroscience 2013 Abstract (WEB), 446.05/GG8
• Oxidized free fatty acid G protein-coupled receptor G2A induces epithelial-to-mesenchymal transition of human astrocytoma U251MG cells., 原口 崇,清水 健志,岸本 幸治,大嶋 紀安,立井 一明,和泉 孝志, Dec. 2012, 日本生化学会大会プログラム・講演要旨集, 85回, 2T10-11
• G2Aはアストロサイトーマ細胞の幹細胞性と悪性度を制御する(G2A Regulates Stemness and malignant behavior of Astrocytoma Cells), 岸本 幸治,谷畑 貴俊,原口 崇,清水 健志,山口 藍子,吉原 利忠,大島 紀安,立井 一明,飛田 成史,対馬 義人,和泉 孝志, Aug. 2012, 日本癌学会総会記事, 71回, 288, 288
• Gタンパク質共役型受容体、G2Aを介したがん幹細胞性制御, 岸本幸治,谷畑貴俊,原口崇,清水健志,大島紀安,立井一明,和泉孝志, May 2012, 脂質生化学研究, 54, 108, 110
• 表面プラズモン共鳴現象を利用した効率的なGPCRリガンドスクリーニング方法, 大嶋紀安,荒木麻理,岸本幸治,岸美紀子,立井一明,和泉孝志, Jun. 2012, 平成24年度 日本生化学会関東支部例会 プログラム・講演要旨集, 44, 44
• 酸化遊離脂肪酸をリガンドとするGタンパク質共役型受容体、G2Aはアストロサイトーマ細胞株のがん幹細胞性を制御し、悪性度を規定する, 岸本幸治,谷畑貴俊,原口崇,清水健志,山口藍子,吉原利忠,大嶋紀安,立井一明,飛田成史,対馬義人,和泉孝志, Jun. 2012, 平成24年度 日本生化学会関東支部例会 プログラム・講演要旨集, 22, 22
• Oxidized Free Fatty Acids-Activated GPCR, G2A Regulates Stemness and Malignant Behavior of An Astrocytoma Cell Line., Koji Kishimoto,Takashi Haraguchi,Kenji Shimizu,Aiko Yamaguchi,Toshitada Yoshihara,Noriyasu Ohshima,Kazuaki Tatei,Seiji Tobita,Yoshito Tsushima,Takashi Izumi, Oct. 2012, Society for Neuroscience 2012 Abstract (WEB), 558.04/R19
• G2Aは神経膠腫細胞株U251に栄養飢餓及び低酸素刺激に対する抵抗性を賦与する, 岸本 幸治,谷畑 貴俊,原口 崇,大嶋 紀安,立井 一明,和泉 孝志, Sep. 2011, 日本生化学会大会プログラム・講演要旨集, 84回, 4T10p-10
• pColdベクターを用いた5-リポキシゲナーゼ(5-LO)の大量発現と精製, 大嶋 紀安,青木 公洋,立井 一明,平野 瞳子,岸本 幸治,和泉 孝志, Dec. 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P-0168
• マウス由来グリセロホスホジエステルホスホジエステラーゼ1(GDE1)の基質特異性と組織分布の解析, 大嶋 紀安,立井 一明,金子 真弓,城 宜嗣,和泉 孝志, Dec. 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 3P-0150
• Analysis of inflammatory lipid mediators induced matrix mineralization regulation mechanism of MC3T3-E1 osteoblast-like cells via actin cytoskeleton reorganization, Hiraku Suzuki,Noriyasu Ohsima,Akimitsu Konishi,Kazuaki TateiSeiichi Sato,Takashi Izumi, Nov. 2018, 第41回日本分子生物学会年会 講演要旨, 1P-0285
• 哺乳動物のGDE群とマウスGDE5の非酵素的機構による骨格筋分化制御, 大嶋紀安,岡崎優利,吉澤郁美,亀山康富,Stefania Mariggio,岡本佳子,立井一明,岸本幸治,小川佳宏,加藤範久,Daniela Corda,矢中則之,和泉孝志, 2011, 53, 208, 209

Presentations

• 群⾺⼤学重点⽀援プロジェクトG2　⽣体分⼦化学を基盤とした⽣命現象の統合的な理解と応⽤　(⽣体分⼦化学プロジェクト）, 松尾⼀郎、⽯井希実、⼤嶋紀安、杉⼭友太、⼤重真彦、森⼝朋尚、神⾕厚輝、佐藤記⼀、⾼橋剛、張慧、吉原利忠、ホサイン, 群馬大学Sメンブレンおよび生体分子化学プロジェクト 第5回産学連携交流会, 09 Dec. 2024, 09 Dec. 2024, 09 Dec. 2024, Japanese, Kiryu, Gunma, Japan, Domestic conference
• 電気鍼治療によるリラクゼーション効果に係る唾液イオンの探索, 明珍 尋紀，久島達也，和泉 孝志，大嶋 紀安，上田 忠治，森 勝伸, 2025年分析化学討論会, 31 May 2025, 31 May 2025, 01 Jun. 2025, Japanese, Japan, Domestic conference
• Identifying salivary stress markers using capillary ion electrophoresis target analysis with electrochemical correction, Hironori Myochin, Tadaharu Ueda, Romanas Chaleckis, Noriyasu Ohshima, Takashi Izumi, Tatsuya Hisajima, Masanobu Mori, 日本化学会第105春季年会, 26 Mar. 2025, 26 Mar. 2025, 29 Mar. 2025, English, Osaka, Japan, Domestic conference
• Assessing stress: Electrochemical Approaches to Biomarker search, Hironori Myochin, Tadaharu Ueda, Romanas Chaleckis, Noriyasu Ohshima, Takashi Izumi, Tatsuya Hisajima, Masanobu Mori, International Conference on Flow Injection Analysis and Related Techniques, 03 Dec. 2024, 03 Dec. 2024, 07 Dec. 2024, English, Chiang Mai, Thailand, International conference
• Ultrasensitive Specific Detection of Anti-influenza A H1N1 Hemagglutinin Monoclonal Antibody Using Silicon Nanowire Field Effect Biosensors, Hui Zhang, Fumiya Osawa, Haru Okamoto, Yawei Qiu, Zhiheng Liu, Noriyasu Ohshima, Taira Kajisa, Toshiya Sakata, Takashi Izumi and Hayato Sone, 37th International Microprocesses and Nanotechnology Conference (MNC 2024), 12 Nov. 2024, 12 Nov. 2024, 15 Nov. 2024, English, Kyoto, Japan, International conference
• Challenges in Forming Sub-10 nm Nanowires via Directed Self-Assembly for Future Applications in Silicon Nanowire Biosensor, Yawei Qiu, Hui Zhang, Fumiya Osawa, Noriyasu Ohshima, Taira Kajisa, Toshiya Sakata, Takashi Izumi, and Hayato Sone, 37th International Microprocesses and Nanotechnology Conference (MNC 2024), 12 Nov. 2024, 12 Nov. 2024, 15 Nov. 2024, English, Kyoto, Japan, International conference
• Enhancing Detection Sensitivity of Si Nanowire Biosensor Through Controlled Channel Impurity Concentrations, Fumiya Osawa, Hui Zhang, Yawei Qiu, Noriyasu Ohshima, Toshiya Sakata, Taira Kajisa, Takashi Izumi, and Hayato Sone, 5th Gunma International Symposium 2025, 23 Jan. 2025, 23 Jan. 2025, 23 Jan. 2025, English, Kiryu, Gunma, Japan, International conference
• Design and Development of Silicon Nanowire Biosensor with Enhanced Sensitivity and Specificity for Biomolecule Detection, Hui Zhang Fumiya Osawa, Yawei Qiu, Haru Okamoto, Zhiheng Liu, Noriyasu Ohshima, Toshiya Sakata, Taira Kajisa, Takashi Izumi, Hayato Sone, 5th Gunma International Symposium 2025, 23 Jan. 2025, 23 Jan. 2025, 23 Jan. 2025, English, Kiryu, Gunma, Japan, International conference
• METABOLISM OF CYCLIC PHOSPHATIDIC ACID IN MAMMALS, Bulgan Munkhtur, Binderiya Tserendagva, Takashi Izumi, Yoji Minamishima, and Noriyasu Ohshima, 5th Gunma International Symposium 2025, 23 Jan. 2025, 23 Jan. 2025, 23 Jan. 2025, English, Kiryu, Gunma, Japan, International conference
• AckAとPta, Fisの機能欠失による大腸菌のホスホマイシン耐性化機構, 平川秀忠、滝田綾子、佐藤百美佳、橋本佑輔、平本卓、大嶋紀安、南嶋洋司、村上正巳、富田治芳, 第97回日本細菌学会総会, 07 Aug. 2024, 07 Aug. 2024, 09 Aug. 2024, Japanese, Japan, Domestic conference
• サイクリックボルタンメトリーを用いた唾液イオン濃度の補正及び正規化, 明珍 尋紀, Chaleckis Romanas, 上田 忠治, Miguel Gonzálvez Noguera, Jie Zhang, 大嶋 紀安, 和泉 孝志, 森 勝伸, 18 May 2024, 18 May 2024, 19 May 2024, Japanese, Japan, Domestic conference
• 非接触型導電率検出キャピラリー電気泳動を用いた寒冷ストレス下における唾液イオンの網羅的解析, 明珍 尋紀, 大嶋 紀安, ハレツキス ロマナス, 上田 忠治, 和泉 孝志, 久島 達也, 森 みかる, 森 勝伸, 2023年日本化学会中国四国支部大会 山口大会, 11 Nov. 2023, 11 Nov. 2023, 12 Nov. 2023, Japanese, Japan, Domestic conference
• Prediction of Optimal Structures for High-Sensitivity Si Nanowire Biosensors Using COMSOL Finite Element Analysis, Hui Zhang, Mayuna Abe, Fumiya Osawa, Yawei Qiu, Noriyasu Ohshima, Taira Kajisa, Toshiya Sakata, Takashi Izumi, Hayato Sone, 第85回 応用物理学会 秋季学術講演会, 19 Sep. 2024, 16 Sep. 2024, 20 Sep. 2024, Japanese, Japan, Domestic conference
• The Possibility of Ultrasensitive Detection of Biomolecules using Silicon Nanowire Biosensor with Structural Optimization, Hui Zhang;Mayuna Abe;Fumiya Osawa;Yawei Qiu;Noriyasu Ohshima;Taira Kajisa;Toshiya Sakata;Takashi Izumi;Hayato Sone, 36th International Microprocesses and Nanotechnology Conference (MNC 2023), Nov. 2023, 14 Nov. 2023, 17 Nov. 2023, English, Japan, International conference
• Siナノワイヤバイオセンサ電気特性と検出感度の幅及び極性依存性, Fumiya Osawa;Hui Zhang;Yawei Qiu;Meiko Itabashi;Noriyasu Ohshima;Taira Kajisa;Toshiya Sakata;Takashi Izumi;Hayato Sone, 第84回応用物理学会秋季学術講演会, 21 Sep. 2023, 19 Sep. 2023, 23 Sep. 2023, Japanese, Japan, Domestic conference
• Estimation of the Depletion Layer Thickness in Silicon Nanowire-Based Biosensors for Elucidating the Fundamental of High Sensitivity Detection, Hui Zhang;Yawei Qiu;Fumiya Osawa;Noriyasu Ohshima;Taira Kajisa;Toshiya Sakata;Takashi Izumi;Hayato Sone, 第84回応用物理学会秋季学術講演会, 21 Sep. 2023, 19 Sep. 2023, 23 Sep. 2023, Japanese, Japan, Domestic conference
• 非接触型導電率検出キャピラリー電気泳動による唾液イオンの分析：冷水刺激前後の唾液イオンの変動解析, 明珍 尋紀;大嶋 紀安;Chaleckis Romanas;森 勝伸, 第83回分析化学討論会, May 2023, 20 May 2023, 21 May 2023, Japanese, Japan, Domestic conference
• Choline化合物摂取時のtrimethylamine-N-oxide産生におけるGDE5/Gpcpd1の機能的関与, 中島領子;乾志帆;川口達也;大嶋紀安;鈴木卓也;中川佳子; 佐久間哲史;山本卓;Thanutchaporn Kumrungsee;矢中規之, 第77回日本栄養・食糧学会大会, May 2023, 12 May 2023, 14 May 2023, Japanese, Sapporo, Japan, Domestic conference
• Functional relationship between phosphatidylcholine profiles and skeletal muscle function—Metabolic analyses of skeletal muscle-specific GDE5 deficient mouse, Rahmawati Aisyah;Noriyasu Ohshima;Daiki Watanabe;Tetsushi Sakuma;Yoshiko Nakagawa;Thanutchaporn Kumrungsee;Shinji Miura;Takashi Yamamoto;Masanobu Wada;Noriyuki Yanaka, 22nd IUNS-ICN International Congress of Nutrition, Dec. 2022, 06 Dec. 2022, 11 Dec. 2022, English, Tokyo, Japan, International conference
• 電子線描画法のよるp型およびn型SiNWの作製とFET特性評価, 板橋芽比子;邱亜威;大澤郁弥;大嶋紀安;和泉孝志;張慧;曾根逸人, 量子生命科学先端フォーラム2022冬の研究会, 25 Nov. 2022, 25 Nov. 2022, 27 Nov. 2022, Japanese, Japan, Domestic conference
• Investigation of Thinning Effect on Sensitivity of Silicon Nanowire Biosensor for Ultra-Sensitive and Specific Biomolecule Detection, Hui Zhang;Yawei Qiu;Fumiya Osawa;Meiko Itabashi;Noriyasu Ohshima;Taira Kajisa; Toshiya Sakata;Takashi Izumi;Hayato Sone, 35th International Microprocesses and Nanotechnology Conference (MNC2022), 08 Nov. 2022, 08 Nov. 2022, 11 Nov. 2022, English, Japan, International conference
• グリセロホスホコリンの吸収、および代謝機構の解明, 乾志帆;中島領子;川口達也;大嶋 紀安;鈴木卓弥;中川佳子;佐久間哲史;Thanutchaporn Kumrungsee;矢中規之, 日本農芸化学会 2022年度中四国支部大会（第63回講演会）, 22 Sep. 2022, 21 Sep. 2022, 22 Sep. 2022, Japanese, Japan, Domestic conference
• マウス由来GDE7は環状ホスファチジン酸を産生する酵素活性を有する, Tserendavga Binderiya;大嶋 紀安;藤田 千明;湯澤 厚二;大嶋 麻理;矢中 規之;南嶋 洋司;和泉 孝志, 第64回 日本脂質生化学, 24 Jun. 2022, 23 Jun. 2022, 24 Jun. 2022, English, Japan, Domestic conference
• Murine GDE4 and GDE7 produce lysophosphatidic acid and/or cyclic phosphatidic acid, Binderiya Tserendavga, Noriyasu Ohshima, Chiaki Fujita, Koji Yuzawa, Mari Ohshima, Noriyuki Yanaka , Yoji A. Minamishima, Takashi Izumi, 第94回日本生化学会大会, 03 Nov. 2021, 03 Nov. 2021, 05 Nov. 2021, English, Japan, Domestic conference
• 電子線描画法を用いた超高感度Siナノワイヤバイオセンサの作製と特性評価, 邱亜威、新井出海、板橋芽比子、大澤郁弥、大嶋紀安、和泉孝志、張慧、曾根逸人, 量子生命科学先端フォーラム　2021年冬の研究会, 16 Dec. 2021, 16 Dec. 2021, 17 Dec. 2021, Japanese, Japan, Domestic conference
• 高感度Siナノワイヤバイオセンサ作製のための最適なドーピング濃度の探求, 新井出海;邱亜威;板橋芽比子;大澤郁弥;大嶋紀安;和泉孝志;張慧;曾根逸人, 量子生命科学先端フォーラム　2021年冬の研究会, 16 Nov. 2021, 16 Dec. 2021, 17 Dec. 2021, Japanese, Japan, Domestic conference
• Analysis of inflammatory lipid mediators induced matrix mineralization regulation mechanism of MC3T3-E1 osteoblast-like cells via actin cytoskeleton reorganization, 鈴木 啓,大嶋 紀安,小西 昭充,立井 一明,佐藤 精一,和泉 孝志, The 42nd Annual Meeting of the Molecular Biology Society of Japan, 06 Dec. 2019, Japanese, Domestic conference
• キャピラリー電気泳動を用いる唾液中の陰及び陽イオンの同時分析と生理活性物質との相関, 青栁啓介,板橋 英之,関 庸一,大嶋紀安,和泉 孝志,葭田 明弘,正保 佳史,牛木 和美,ララサティ マルタ,村上正巳,新井 淑弘,金子 伊樹,森 勝伸, 第36回イオンクロマトグラフィー討論会, 13 Dec. 2019, Japanese, Domestic conference
• Fabrication of Ultrahigh-Sensitivity Silicon Nanowire Biosensor by CMOS-Compatible Process for Detecting Biomolecules at Low Concentrations, Hui Zhang,Kei Okabe,Naoki Kikuchi,Noriyasu Ohshima,Taira Kajisa,Toshiya Sakata,Takashi Izumi,Hayato Sone, International Conference on Mechanical, Electrical and Medical Intelligent System 2019 (ICMEMIS2019), 04 Dec. 2019, English, International conference
• シリコンナノワイヤ細線化によるバイオセンサ検出感度の評価, 張慧\,岡部圭,菊池直樹,大嶋紀安,加治佐平,坂田利弥,和泉孝志,曾根逸人, 第80回応用物理学会秋季学術講演会, 18 Sep. 2019, Japanese, Domestic conference
• キャピラリー電気泳動を用いる唾液中の 陰及び陽イオンの同時分析と生理活性物質との相関, 青栁啓介,板橋 英之,関 庸一,大嶋紀安,和泉 孝志, 日本分析化学会 第68年会, 11 Sep. 2019, Japanese, Domestic conference
• 家庭環境内における重金属類曝露シナリオの解明－調査方法の検討, 仲井邦彦,龍田希,岩井美幸,磯部友彦,西浜柚季子,中山祥嗣,和泉孝 志,大日方英,大嶋紀安,ロマナス ハレツキス, 第28回環境化学討論会, 12 Jun. 2019, Japanese, Domestic conference
• Elucidation of heavy metal exposure scenario in home environment - establishment of research method, Kunihiko Nakai,Nozomi Tatsuta,Miyuki Iwai,Tomohiko Isobe,Yukiko Nishihama,Shoji F. Nakayaka,Takashi Izumi,Hideru Obinata,Noriyasu Ohshima,Romanas Chaleckis, The 89th Annual Meeting of the japanese Society for Hygiene, 01 Feb. 2019, Nagoya
• Fabrication of High-Sensitivity Silicon Nanowire Biosensor by Electron Beam Lithography and Detection of Antigen-Antibody Specific Binding at Attomolar Concentration, 張慧,大嶋紀安,大嶋駆,菊池直樹,加治佐平,坂田利弥,和泉孝志,曾根逸人, 第66回応用物理学会春季学術講演会, 09 Mar. 2019, Japanese, Domestic conference
• Structure and Function of Thermus thermophilus 2-keto-3-deoxygluconate kinase, Ohshima N,Inagaki E,Kajihara Y,Yasuike K,Takio K,Tahirov TH, The 1st Pacific-Rim International Conference on Protein Science (The 4th Annual Meeting of the Protein Science Society of Japan), 2004, English, 横浜, International conference
• Crystallographic and Kinetic Analysis of the Osmotically Inducible Protein C from Thermus Thermophilis HB8, Rehse PH,Oshima N,Nodake Y,Tahirov TH, The 1st Pacific-Rim International Conference on Protein Science (The 4th Annual Meeting of the Protein Science Society of Japan), 2004, English, 横浜, International conference
• Crystal Structure of NADP-dependent 3-Hydroxyisobutyrate Dehydrogenase from Thermus themophilus HB8, Lokanath NK,Ohshima N,Shiromizu I,Suguhara M,Kunishima N, CURRENT TRENDS IN DRUG DISCOVERY RESEARCH (CTDDR-2004), 2004, English, LUCKNOW (INDIA), International conference
• ハイスループットファクトリーにおける好熱菌タンパク質の機能解析, 大嶋紀安,菅原真由美,前川圭美,山下さおり,宮野雅司,瀧尾擴士, 超好熱古細菌の構造ゲノミクスのためのワークショップ, 2003, Japanese, 兵庫, Domestic conference
• Functional Analysis of 2-keto-3-deoxygluconate kinase, 大嶋紀安,浮田陽子,Tahir H. TAHIROV,稲垣栄二,梶原康宏,横山茂之,倉光成紀,宮野雅司,瀧尾擴士, 高度好熱菌丸ごと一匹プロジェクト第二回ストラクチュローム連携連絡会, 2003, Japanese, 兵庫, Domestic conference
• High Resolution Native and Ligand-bound Structures of Deoxyribose-phosphate Aldolase from Thermus thermophilus HB8, Lokanath NK,Shiromizu I,Ohshima N,Takio K,Nodake Y,Kuramitsu S,Yokoyama S,Miyano M,Kunishima N, International Symposium on Diffraction Structural Biology 2003, 2003, English, 筑波, International conference
• Receptor-dependent Metabolism of PAF by Macrophages, Ohshima N,Ishii S,Izumi T,Shimizu T, 12th International Conference on ADVANCES IN PROSTAGLANDIN, LEUKOTRIENE AND OTHER BIOACTIVE LIPID RESEARCH; Basic Science and Clinical Applications, 2002, English, Istanbul, International conference
• ヒト５−リポキシゲナーゼ――アラキドン酸酸素添加酵素, 大嶋紀安, 第２回理研構造生物ポスターセッション, 2002, Japanese, 兵庫, Domestic conference
• マウスマクロファージにおける受容体依存的なPAFの分解, 大嶋紀安,石井聡,和泉孝志,清水孝雄, 日本生化学会, 2001, Japanese, 京都, Domestic conference
• Receptor-Dependent Metabolism of PAF by Macrophages, Ohshima N,Ishii S,Izumi T,Shimizu T, Seventh International Congress on Platelet-Activating Factor and Lipid Mediators, 2001, English, 東京, International conference
• アシルプロテインチオエステラーゼ1/リゾホスホリパーゼ1の活性と細胞内局在, 平野瞳子,岸美紀子,杉本博之,田口良,大日方英,大嶋紀安,立井一明,和泉孝志, 第52回日本脂質生化学会, 2010, Japanese, 群馬, Domestic conference
• Functional role of a novel glycerophosphodiester phosphodiesterase GDE5 during myoblast differentiation., 吉澤郁美,岡本佳子,前田将宏,岡崎優利,大嶋紀安,和泉孝志,加藤範久,矢中規之, 第32回日本分子生物学会年会, 2009, Japanese, 横浜, Domestic conference
• 9-HODE-activated GPCR, G2A induces epithelial-to-mesenchymal transition of human astrocytoma cells prior to generation of stem cell-like properties., Kishimoto K,Haraguchi T,Shimizu K,Yamaguchi A,Yoshihara T,Ohshima N,Tatei K,Tobita S,Tsushima Y,Izumi T, Society of Neuroscience 2013, Nov. 2013, English, San Diego
• Novel function of 9(S)-hydroxyoctadecadienoic acid on proliferation of T cells, Melisa I. Baarliana,Kishi M,Obinata H,Ogawa A,Kishimoto K,Ohshima N,Tatei K,Izumi T, 第52回日本脂質生化学会, 2010, English, 群馬, Domestic conference
• Characterization of mouse glycerophosphodiester phosphodiesterase 1 (GDE1), Ohshima N,Kaneko M,Takahashi N,Takio K,Shiro Y,Tatei T,Izumi T, 4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009), 2009, English, 東京, International conference
• ほ乳類グリセロホスホジエステルホスホジエステラーゼの酵素学的解析, 大嶋紀安,金子真弓,瀧尾擴士,城宜嗣,和泉孝志, 生命科学系グローバルCOEネットワーク・フォーラム2009, Nov. 2009, Japanese, 東京, Domestic conference
• 新規酵素GDE7はオートタキシン活性を有し，LPAおよびalkyl-LPAの産生に関与する, 工藤 尊裕,大嶋 紀安,Stefania Mariggio,本田 絢子,長野 友美,加藤 範久,Daniela Corda,和泉 孝志,矢中 規之, 日本農芸化学会2013年度仙台大会, Mar. 2013, Japanese, 仙台, Domestic conference
• 群馬のプロテオミクスの最前線, Noriyasu Ohshima, 第１回群馬大学プロテオミクス研究会, 2011, Japanese, 前橋, Domestic conference
• 哺乳動物のGDE群とマウスGDE5の非酵素的機構による骨格筋分化制御, 大嶋紀安,岡崎優利,吉澤郁美,亀井康富,Stefania Mariggi?,岡本佳子,立井一明,岸本幸治,小川佳宏,加藤範久,Daniela Corda,矢中規之,和泉孝志, 第53回日本脂質生化学会, Aug. 2011, Japanese, 東京, Domestic conference
• Gタンパク質共役型受容体、G2Aはヒトアストロサイトーマ細胞株のがん幹細胞性を制御する, 岸本幸治,原口崇,清水健志,山口藍子,吉原利忠,大嶋紀安,立井一明,飛田成史,飯田靖彦,対馬義人,和泉孝志, 平成25年度 日本生化学会関東支部例会, 2013, Japanese, 甲府, Domestic conference
• G2A Regulates Stemness and malignant behavior of Astrocytoma Cells., 岸本 幸治,谷畑 貴俊,原口 崇,清水 健志,山口 藍子,吉原 利忠,大島 紀安,立 井 一明,飛田 成史,対馬 義人,和泉 孝志, 第71回日本癌学会学術集会, 2012, Japanese, 札幌, Domestic conference
• G2Aは神経膠腫細胞株U251に栄養飢餓及び低酸素刺激に対する抵抗性を賦与する, 岸本幸治,谷畑貴俊,原口崇,大嶋紀安,立井一明,和泉孝志, 第84回日本生化学会, 2011, Japanese, 京都, Domestic conference
• pColdベクターを用いた5-リポキシゲナーゼ(5-LO)の大量発現と精製, 大嶋紀安,青木公洋,立井一明,平野瞳子,岸本幸治,和泉孝志, 第83回日本生化学会, 2010, Japanese, 神戸, Domestic conference
• マウス由来グリセロホスホジエステルホスホジエステラーゼ１(GDE1)の基質特異性と組織分布の解析, 大嶋紀安,立井一明,金子真弓,城宜嗣,和泉孝志, 第83回日本生化学会, 2010, Japanese, 神戸, Domestic conference
• 新規因子GDE5の筋芽細胞分化における役割、および骨格筋特異的GDE5過剰発現マウスの形質の解析, 吉澤郁美,岡本佳子,前田将宏,岡崎優利,大嶋紀安,和泉孝志,加藤範久,矢中規之, 日本農芸化学会2009年度大会, Mar. 2009, Japanese, 福岡, Domestic conference
• Gタンパク質共役型受容体、G2Aを介したがん幹細胞性制御, 岸本幸治,谷畑貴俊,原口崇,清水健志,大嶋紀安,立井一明,和泉孝志, 第54回日本脂質生化学会, 2012, Japanese, 福岡, Domestic conference
• 酸化遊離脂肪酸をリガンドとするGタンパク質共役型受容体、G2Aはアストロサイトーマ細胞株のがん幹細胞性を制御し、悪性度を規定する, 岸本幸治,谷畑貴俊,原口崇,清水健志,山口藍子,吉原利忠,大嶋紀安,立井一明,飛田成史,対馬義人,和泉孝志, 2012 日本生化学会関東支部例会, 2012, Japanese, 前橋, Domestic conference
• 表面プラズモン共鳴現象を利用した効率的なGPCRリガンドスクリーニング方法, 大嶋紀安,荒木麻理,岸本幸治,岸美紀子,立井一明,和泉孝志, 2012 日本生化学会関東支部例会, 2012, Japanese, 前橋, Domestic conference
• 表面プラズモン共鳴現象を用いた生細胞におけるGPCRシグナルの検出, 陳可欣,大日方英,岸美紀子,大嶋紀安,立井一明,和泉孝志, 第51回日本脂質生化学会, 2009, Japanese, 名古屋, Domestic conference
• Oxidized free fatty acid G protein-coupled receptor G2A induces epithelial-to-mesenchymal transition of human astrocytoma U251MG cells., 原口 崇,清水 健志,岸本 幸治,大嶋 紀安,立井 一明,和泉 孝志, 第85回日本生化学会, 2012, Japanese, 福岡, Domestic conference
• Oxidized Free Fatty Acids-Activated GPCR, G2A Regulates Stemness and Malignant Behavior of An Astrocytoma Cell Line., Koji Kishimoto,Takashi Haraguchi,Kenji Shimizu,Aiko Yamaguchi,Toshitada Yoshihara,Noriyasu Ohshima,Kazuaki Tatei,Seiji Tobita,Yoshito Tsushima,Takashi Izumi, Society for Neuroscience 2012, 2012, English, New Orleans, International conference
• マウス由来グリセロホスホジエステルホスホジエステラーゼ１(GDE1)の酵素学的解析, 大嶋紀安,金子真弓,瀧尾擴士,城宜嗣,和泉孝志, 生化学会関東支部会, 2008, Japanese, 桐生, Domestic conference
• Characterization of murine glycerophosphodiester phosphodiesterase 1 (GDE1), Noriyasu OHSHIMA,Naoko TAKAHASHI,Koji TAKIO,Yoshitsugu SHIRO, 分子生物生化学合同大会, 2007, Japanese, 横浜, Domestic conference
• First crystal structure of the 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase, Neratur K. Lokanath,Mitsuhiro Nakamura,Noriyasu Ohshima,Koji Takio,Naoki Kunishima, Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan, 2006, English, 沖縄, International conference
• Functional analysis of intracellular glycerophosphodiester phosphodiesterase (UgpQ) from E.coli, Noriyasu Ohshima,Saori Yamashita,Chizu Kuroishi,Koji Takio,Yoshitsugu Shiro, Post早石シンポジウム, 2006, Japanese, 兵庫, Domestic conference
• Crystal structure of the NADP-dependent 3-hydroxyisobutyrate dehydrogenase, Lokanath Neratur K,Ohshima Noriyasu,Takio Koji,Shiromizu Ikuya,Kuroishi Chizu,Okazaki Nobuo,Kuramitsu Seiki,Yokoyama Shigeyuki,Miyano Masashi,Kunishima Naoki, 20th Congress of the International Union of Crystallography (IUCr2005), 2005, English, Florence, International conference
• Crystal Structure of ATP-dependent phoenolpyruvate Carboxykinase from Thermus thermophilus HB8 at 2.0 A Resolution, Michihiro Sugahara,Noriyasu Ohshima,Yoko Ukita,Tomoyuki Tanaka,Naoki Kunishima, 8th International Conference on Biology and Synchrotron Radiation (BSR2004), 2004, English, 姫路, International conference
• Crystal structure of Thermus thermophilus Δ1-pyrroline-5-carboxylate dehydrogenase, Eiji Inagaki,Noriyasu Ohshima,Chizu Kuroishi,Tahir H. Tahirov, 3rd International Conference on Structural Genomics (ICSG 2004), 2004, English, Washington DC, International conference
• 大腸菌由来細胞質型グリセロホスホジエステルホスホジエステラーゼ (UgpQ)の酵素反応解析, 大嶋紀安,山下さおり,前川圭美,黒石千寿,瀧尾擴士, 第４６回日本脂質生化学会, 2004, Japanese, 熊本, Domestic conference
• 新規脳ジアシルグリセロールリパーゼの同定, 荒木麻理,麻生知寿,大嶋紀安,立井一明,平野瞳子,杉本博之,岸美紀子,岸本幸治,和泉孝志, 第55回日本脂質生化学会, 2013, Japanese, 松島, Domestic conference
• Fabrication of N-type Silicon Nanowire Using Electron Beam Lithography for Peptide Detection, Yuya Sakurai,Tomoya Tashiro,Noriyasu Oshima,Kakeru Oshima,Sumio Hosaka,Takashi Izumi,Hayato Sone, 3rd International Symposium of Gunma University Medical Innovation and 8th International Conference on Advanced Micro‐Device Engineering (GUMI&AMDE 2016), 2016, English, 桐生, International conference
• 電子線リソグラフを用いた超高感度Siナノワイヤバイオセンサの創製, 曾根 逸人,櫻井 祐也,田代 朋也,大嶋 紀安,和泉 孝志, 医理工生命医科学融合医療イノベーションプロジェクト平成28年度成果報告会, 2017, 前橋
• ラット脳ジアシルグリセロールリパーゼの精製と機能解析, 大嶋紀安,荒木麻理,麻生千寿,立井一明,岸本幸治,和泉孝志, 群馬大学・秋田大学 連携 第3回 生体情報研究シンポジウム, 2014, Japanese, 秋田, Domestic conference
• Identification and functional analyses of a novel diacylglycerol lipase from rat brain, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Takashi Izumi, International Symposium co-sponsored by Joint/Usage Research Program and Lifestyle Disease Project, 2014, English, 前橋, International conference
• GDE4 and GDE7 Produce Lysophosphatidic Acid by Lysophospholipase D Activity, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Takashi Izumi, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015), 2015, English, 東京, International conference
• Identification and functional analyses of a novel diacylglycerol lipase from rat brain, Chiaki Isaji,Takahiro Kudo,Noriyasu Ohshima,Yosuke Yamashita,Mari Araki,Ayako Honda,Tomomi Nagano,Norihisa Kato,Akiyoshi Konishi,Koji Kishimoto,Kazuaki Tatei,Noriyuki Yanaka,Takashi Izumi, 6th international conference on Phospholipase A2 and Lipid Mediators (PLM2015), 2015, English, 東京, International conference
• 新規リゾホスファチジン酸産生酵素、GDE4およびGDE7の酵素学的解析, 大嶋紀安,工藤 尊裕,山下洋介,荒木麻理,伊佐治千明,本田絢子,長野友美,立井一明,加藤範久,矢中規之,和泉孝志, 第57回 日本脂質生化学会, 2015, Japanese, 東京, Domestic conference
• Analysis of inflammatory lipid mediators induced matrix mineralization regulation mechanism of MC3T3-E1 osteoblast-like cells via actin cytoskeleton reorganization, Hiraku Suzuki,Noriyasu Ohsima,Akimitsu Konishi,Kazuaki TateiSeiichi Sato,Takashi Izumi, ConBio2018, 2018, English, Yokohama, Domestic conference
• Fabrication of Sub-20 nm Width Silicon Nanowire-Based Biosensor for Detecting Biomolecules at Attomolar Concentrations, Hui Zhang,Kakeru Oshima,Naoki Kikuchi,Noriyasu Ohshima,Taira Kajisa,Toshiya Sakata,Takashi Izumi,Hayato Sone2sone, 14th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures (ACSIN-14) & 26th International Colloquium on Scanning Probe Microscopy (ICSPM26), 2018, English, Sendai, International conference
• “Non-targeted analysis of exogenous compounds in human urine using GC-MS”, and “Lipidomic analysis of human serum and liver using LC-MS and GC-MS”, Noriyasu Ohshima, スウェーデンとの共同研究(STINT)に関するスタートアップセミナー, 2018, English, Maebashi, International conference
• Fabrication of Highly Sensitive Silicon Nanowire Biosensor by Electron Beam Lithography for Detecting Antigen-Antibody Specific Binding at Amottmolar Concentration, Hui Zhang,Noriyasu Ohshima,Kakeru Oshima,Naoki Kikuchi,Taira Kajisa,Toshiya Sakata,Takashi Izumi,Hayato Sone, 5th International Symposium of Gunma University Medical Innovation (GUMI) and 9th International Conference on Advanced Micro-Device Engineering (AMDE), 2018, English, Kiryu, International conference
• Osteogenic responses to mechanical stress at various differential stages of MC3T3-E1 osteoblast-like cells, 鈴木 啓,大嶋 紀安,小西 昭充,立井 一明,佐藤 精一,和泉孝志, ConBio2017, 2017, 神戸
• Lipidomic analysis of GDE4-overexpressing cells, Noriyasu Ohshima,Mari Araki,Hideru Obinata,Akimitsu Konishi,Hiraku Suzuki,Kazuaki Tatei,Takashi Izumi, ConBio2017, 2017, English, 神戸, Domestic conference
• Fabrication of Silicon Nanowire Biosensor Using Electron Beam Lithography and Low-Concentration Antibody Detection, Hayato Sone,Tomoya Tashiro,Kakeru Oshima,Yuya Sakurai,Hui Zhang,Takaaki Suzuki,Noriyasu Ohshima,Takashi Izumi, 4th International Symposium of Gunma University Medical Innovation (GUMI2017), 2017, English, 桐生, International conference
• 電子線リソグラフィを用いたSiナノワイヤバイオセンサの作製と低濃度抗体検出, 田代朋也,大嶋駆,櫻井祐也,張慧,鈴木孝明,大嶋紀安,和泉孝志,曾根逸人, バイオ・マイクロシステム研究会, 2017, Japanese, Domestic conference
• 化学物質曝露評価における定量的メタボロミクスの現状と課題, 和泉孝志,大日方英,大嶋紀安,Chaleckis\, Romanas, 第65回質量分析総合討論会, 2017, Japanese, 筑波, Domestic conference
• 可溶性2-アラキドノイルグリセロール産生酵素、DDHD2の酵素学的解析, 荒木麻理,大嶋紀安,麻生知寿,小西昭充,大日方英,立井一明,和泉孝志, 第58回 日本脂質生化学会, 2016, 秋田
• Fabrication of N-type Silicon Nanowire Using Electron Beam Lithography for Antibody Detection, Hayato Sone,Yuya Sakurai,Tomoya Tashiro,Noriyasu Ohshima,Sumio Hosaka,Takashi Izumi, 医理工生命医科学融合医療イノベーションプロジェクト平成27年度成果報告会, 2016, 前橋
• Purification and characterization of a soluble diacylglycerol lipase from rat brain, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Hideru Obinata,Takashi Izumi, 14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases, 2015, English, Budapest, International conference
• 新規酵素GDE4およびGDE7は，LPAおよびalkyl-LPAの産生に関与する, 工藤尊裕,大嶋紀安,Stefania Mariggio,加藤範久,Daniela Corda,和泉孝志,矢中規之, 日本農芸化学会中四国支部第41回講演会, Jan. 2015, Japanese, 下関, Domestic conference
• Identification of a novel diacylglycerol lipase from rat brain, Mari Araki,Chizu Aso,Noriyasu Ohshima,Kazuaki Tatei,Tohko Hirano,Hiroyuki Sugimoto,Mikiko Kishi,Koji Kishimoto,Takashi Izumi, 第86回日本生化学会, 2013, English, 横浜, Domestic conference
• Identification of a novel diacylglycerol lipase from rat brain, 第86回日本生化学会, 2013

Industrial Property Rights

• Patent right, 特願2017-094949

Research Projects

• Apr. 2018, Mar. 2023, Competitive research funding
• Apr. 2012, Mar. 2017, Competitive research funding
• Apr. 2011, Mar. 2014, Competitive research funding
• Apr. 2013, Mar. 2014, Competitive research funding
• Apr. 2005, Mar. 2008, Principal investigator, Competitive research funding

Social Contribution

Social Contribution

• 2023 年度医学部医学科オープンキャンパス, 14 Aug. 2023, 18 Aug. 2023　(Target:　Junior high school students, High school students)
• 世界脳週間, Apr. 2008, Apr. 2018
• 世界脳週間, 16 Jun. 2019, 16 Jun. 2019
• 群馬ちびっこ大学, 10 Aug. 2019, 11 Aug. 2019, Festival
• 2024 年度医学部医学科オープンキャンパス, 16 Aug. 2024, 22 Aug. 2024　(Target:　Junior high school students, High school students)
• 2022 年度医学部医学科オープンキャンパス, 12 Aug. 2022, 19 Aug. 2022　(Target:　Junior high school students, High school students)
• 2021 年度医学部医学科オープンキャンパス, 10 Aug. 2021, 18 Aug. 2021　(Target:　Junior high school students, High school students)