Researcher Profile and Settings

Researcher

• Name

  Kitamura TADAHIRO

Profile and Settings

• Name

  TADAHIRO, Kitamura

Foreign language

• Use in presentation

  English, English

• Use in publication

  English, English

Affiliation

• Gunma University, Professor
• Gunma University, Professor

Education

• 1996
• 1989, Kobe University, School of Medicine, Faculty of Medicine
• 1996, Kobe University Graduate School of Medicine / School of Medicine, Graduate School, Division of Medical Sciences, Internal Medicine
• 1989, Kobe University, Faculty of Medicine, Department of Medicine

Degree

• MD (Doctor of Medicine)
• MD (Doctor of Medicine)
• MD (Doctor of Medicine)

Association Memberships

• Japan Diabetes Society
• Japan Endocrine Society
• The Endocrine Society
• The American Diabetes Association

Research Experience

• 1996, 1999, Research Fellow, The Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
• 1999, 2000, JSPS Research Fellow in Biomedical and Behavioral Research at National Institutes of Health, Bethesda, MD
• 2000, 2002, JDF (Juvenile Diabetes Foundation) Postdoctoral Research Fellow, Diabetes Research Unit, Division of Endocrinology, Department of Medicine, Columbia University, New York, NY
• 2002, 2005, Research Fellow, Diabetes Research Unit, Division of Endocrinology, Department of Medicine, Columbia University, New York, NY
• 2005, 2006, Assistant Professor, Diabetes Research Unit, Division of Endocrinology, Department of Medicine, Columbia University, New York, NY
• 2006, 9999, Professor, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
• 2009, 9999, Director, Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
• 2010, 9999, Visiting Professor, Akita University Graduate School of Medicine, Akita, Japan

Research Activities

Research Areas

• Life sciences, Metabolism and endocrinology
• Life sciences, Metabolism and endocrinology

Research Interests

• Diabetes
• Metabolism
• Endocrinology

Research Themes

• Molecular Mechanism of Diabetes, Diabetes, Personal, 1992, -, Metabolism Studies, Endocrinology, Grant-in-Aid for Scientific Research
• Central regulation of food intake and energy metabolism, Hypothalamus, Appetite, Obesity, Metabolism, Domestic Collaboration, 2006, -, Metabolism Studies, Endocrinology, Grants and Funding

Published Papers

• ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption., Takehiro Kato; Katsumi Iizuka; Ken Takao; Yukio Horikawa; Tadahiro Kitamura; Jun Takeda, 12 Mar. 2018, Nutrients, 10, 3, E340, Scientific journal

  DOI
• The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells., Seiji Torii; Chisato Kubota; Naoya Saito; Ayumi Kawano; Ni Hou; Masaki Kobayashi; Ryoko Torii; Masahiro Hosaka; Tadahiro Kitamura; Toshiyuki Takeuchi; Hiroshi Gomi, 20 Apr. 2018, The Journal of biological chemistry, 293, 16, 5920, 5933, Scientific journal

  DOI
• A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice., Tsutomu Sasaki; Rika Numano; Hiromi Yokota-Hashimoto; Sho Matsui; Naobumi Kimura; Hideyuki Takeuchi; Tadahiro Kitamura, 24 May 2018, Molecular brain, 11, 1, 28, 28, Scientific journal

  DOI
• Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance., Maryam Gulshan; Keisuke Yaku; Keisuke Okabe; Arshad Mahmood; Tsutomu Sasaki; Masashi Yamamoto; Keisuke Hikosaka; Isao Usui; Tadahiro Kitamura; Kazuyuki Tobe; Takashi Nakagawa, Aug. 2018, Aging cell, 17, 4, e12798, Scientific journal

  DOI
• Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice., Sho Matsui; Tsutomu Sasaki; Daisuke Kohno; Keisuke Yaku; Ayumu Inutsuka; Hiromi Yokota-Hashimoto; Osamu Kikuchi; Takayoshi Suga; Masaki Kobayashi; Akihiro Yamanaka; Akihiro Harada; Takashi Nakagawa; Tatsushi Onaka; Tadahiro Kitamura, 02 Nov. 2018, Nature communications, 9, 1, 4604, 4604, Scientific journal

  DOI
• SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels., Takayoshi Suga; Osamu Kikuchi; Masaki Kobayashi; Sho Matsui; Hiromi Yokota-Hashimoto; Eri Wada; Daisuke Kohno; Tsutomu Sasaki; Kazusane Takeuchi; Satoru Kakizaki; Masanobu Yamada; Tadahiro Kitamura, Jan. 2019, Molecular metabolism, 19, 1, 12, Scientific journal

  DOI
• Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes., Raishi Ichikawa; Koji Takano; Kazumi Fujimoto; Tetsuya Motomiya; Masaki Kobayashi; Tadahiro Kitamura; Masayoshi Shichiri, 29 Aug. 2019, Endocrine journal, 66, 8, 663, 675, Scientific journal

  DOI
• Cell Autonomous Dysfunction and Insulin Resistance in Pancreatic α Cells., Norikiyo Honzawa; Kei Fujimoto; Tadahiro Kitamura, 28 Jul. 2019, International journal of molecular sciences, 20, 15, E3699, Scientific journal

  DOI
• Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice., Yuka Inaba; Emi Hashiuchi; Hitoshi Watanabe; Kumi Kimura; Makoto Sato; Masaki Kobayashi; Michihiro Matsumoto; Tadahiro Kitamura; Masato Kasuga; Hiroshi Inoue, 01 Dec. 2019, Endocrinology, 160, 12, 2811, 2824, Scientific journal

  DOI
• FOXO1 suppresses PGC-1β gene expression in skeletal muscles., Shiho Nakai; Mamoru Oyabu; Yukino Hatazawa; Shiori Akashi; Tadahiro Kitamura; Shinji Miura; Yasutomi Kamei, Jul. 2020, FEBS open bio, 10, 7, 1373, 1388, Scientific journal

  DOI
• The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis., Tetsuya Hosooka; Yusei Hosokawa; Kaku Matsugi; Masakazu Shinohara; Yoko Senga; Yoshikazu Tamori; Chikako Aoki; Sho Matsui; Tsutomu Sasaki; Tadahiro Kitamura; Masashi Kuroda; Hiroshi Sakaue; Kazuhiro Nomura; Kei Yoshino; Yuko Nabatame; Yoshito Itoh; Kanji Yamaguchi; Yoshitake Hayashi; Jun Nakae; Domenico Accili; Takehiko Yokomizo; Susumu Seino; Masato Kasuga; Wataru Ogawa, 26 May 2020, Proceedings of the National Academy of Sciences of the United States of America, 117, 21, 11674, 11684, Scientific journal

  DOI
• Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression., Ayako Fukunaka; Toshiyuki Fukada; Jinhyuk Bhin; Luka Suzuki; Takamasa Tsuzuki; Yuri Takamine; Bum-Ho Bin; Toshinori Yoshihara; Noriko Ichinoseki-Sekine; Hisashi Naito; Takeshi Miyatsuka; Shinzaburo Takamiya; Tsutomu Sasaki; Takeshi Inagaki; Tadahiro Kitamura; Shingo Kajimura; Hirotaka Watada; Yoshio Fujitani, Aug. 2017, PLoS genetics, 13, 8, e1006950, Scientific journal

  DOI
• Intracerebroventricular injection of ghrelin decreases wheel running activity in rats., Yumiko Miyatake; Tetsuya Shiuchi; Kazuaki Mawatari; Satomi Toda; Yasuko Taniguchi; Akari Futami; Fukiko Sato; Masashi Kuroda; Mayu Sebe; Rie Tsutsumi; Nagakatsu Harada; Yasuhiko Minokoshi; Tadahiro Kitamura; Koro Gotoh; Masaki Ueno; Yutaka Nakaya; Hiroshi Sakaue, 05 Jan. 2017, Peptides, Vol.87, 12, 19, Scientific journal

  DOI
• Role of novel variants of PGC-1 alpha in the pathogenesis of obesity, Kazuhiro Nomura; Tetsuya Hosooka; Tsutomu Sasaki; Tadahiro Kitamura; Hiroshi Sakaue; Masato Kasuga; Wataru Ogawa, Oct. 2016, DIABETES RESEARCH AND CLINICAL PRACTICE, 120, S191, S191
• Intracerebroventricular injection of adiponectin regulates locomotor activity in rats., Yumiko Miyatake; Tetsuya Shiuchi; Tomoyo Ueta; Yasuko Taniguchi; Akari Futami; Fukiko Sato; Tadahiro Kitamura; Rie Tsutsumi; Nagakatsu Harada; Yutaka Nakaya; Hiroshi Sakaue, 2015, The journal of medical investigation : JMI, 62, 3-4, 199, 203, Scientific journal

  DOI
• Hypothalamic Sirt1 and regulation of food intake, Tadahiro Kitamura; Tsutomu Sasaki, Sep. 2012, Diabetology International, 3, 3, 109, 112, Scientific journal

  DOI
• 食欲制御の最前線 Sirt1制御と食欲, 佐々木努; 北村忠弘, 2011, 37, 1, 16, 19
• 摂食制御の分子過程 POMC/CART(視床下部におけるFoxO1とSirt1), 北村忠弘; 佐々木努, 2011, 62, 1, 26, 30
• Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide., Tsutomu Sasaki; Hye-Jin Kim; Masaki Kobayashi; Yukari-Ido Kitamura; Hiromi Yokota-Hashimoto; Tetsuya Shiuchi; Yasuhiko Minokoshi; Tadahiro Kitamura, Jun. 2010, Endocrinology, 151, 6, 2556, 66, Scientific journal

  DOI
• The cathepsin L gene is a direct target of FOXO1 in skeletal muscle., Yoshihiro Yamazaki; Yasutomi Kamei; Satoshi Sugita; Fumiko Akaike; Sayaka Kanai; Shinji Miura; Yukio Hirata; Bruce R Troen; Tadahiro Kitamura; Ichizo Nishino; Takayoshi Suganami; Osamu Ezaki; Yoshihiro Ogawa, 15 Mar. 2010, The Biochemical journal, 427, 1, 171, 8, Scientific journal

  DOI
• The cathepsin L gene is a direct target of FOXO1 in skeletal muscle, Yoshihiro Yamazaki; Yasutomi Kamei; Satoshi Sugita; Fumiko Akaike; Sayaka Kanai; Shinji Miura; Yukio Hirata; Bruce R. Troen; Tadahiro Kitamura; Ichizo Nishino; Takayoshi Suganami; Osamu Ezaki; Yoshihiro Ogawa, Apr. 2010, BIOCHEMICAL JOURNAL, 427, 1, 171, 178, Scientific journal

  DOI
• Roles of FoxO1 and Sirt1 in the central regulation of food intake., Tsutomu Sasaki; Tadahiro Kitamura, 2010, Endocrine journal, 57, 11, 939, 46, Scientific journal

  DOI
• Tyrosine phosphorylation of p62Dok induced by cell adhesion and insulin: possible role in cell migration, Tetsuya Noguchi; Takashi Matozaki; Kenjiro Inagaki; Masahiro Tsuda; Kaoru Fukunaga; Yukari Kitamura; Tadahiro Kitamura; Kozui Shii; Yuji Yamanashi; Masato Kasuga, 1999, EMBO J., 18, 7, 1748, 1760, Scientific journal

  DOI
• Effects of the Once-Weekly DPP4 Inhibitor Omarigliptin on Glycemic Control in Patients with Type 2 Diabetes Mellitus on Maintenance Hemodialysis: A 24-Week Open-Label, Multicenter Randomized Controlled Study., Yuta Yoshizawa; Michihiro Hosojima; Hideyuki Kabasawa; Naohito Tanabe; Daisuke Ugamura; Yutaka Koda; Hisaki Shimada; Tetsuya Takasawa; Takahito Ito; Tadahiro Kitamura; Masaki Kobayashi; Yoshiki Suzuki; Ichiei Narita; Akihiko Saito, Mar. 2021, Diabetes therapy : research, treatment and education of diabetes and related disorders, 12, 3, 655, 667, Scientific journal

  DOI
• Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load., Naoki Kuramoto; Kazuhiro Nomura; Daisuke Kohno; Tadahiro Kitamura; Gerard Karsenty; Tetsuya Hosooka; Wataru Ogawa, 10 Feb. 2021, Scientific reports, 11, 1, 3447, 3447, Scientific journal

  DOI
• Pseudo-hyperglucagonemia was observed in pancreatectomized patients when measured by glucagon sandwich enzyme-linked immunosorbent assay., Masaki Kobayashi; Hironori Waki; Hitomi Nakayama; Atsushi Miyachi; Eri Mieno; Hitoshi Hamajima; Moritaka Goto; Kentaro Yamada; Toshimasa Yamauchi; Takashi Kadowaki; Tadahiro Kitamura, Feb. 2021, Journal of diabetes investigation, 12, 2, 286, 289, Scientific journal

  DOI
• HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1., Yoshifumi Sato; Md Mostafizur Rahman; Masaki Haneda; Tomonori Tsuyama; Tomoya Mizumoto; Tatsuya Yoshizawa; Tadahiro Kitamura; Frank J Gonzalez; Ken-Ichi Yamamura; Kazuya Yamagata, 01 Nov. 2020, Biochimica et biophysica acta. Molecular basis of disease, 1866, 11, 165898, 165898, Scientific journal

  DOI
• Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis., Hirotsugu Uzawa; Daisuke Kohno; Tomoaki Koga; Tsutomu Sasaki; Ayako Fukunaka; Toshiaki Okuno; Airi Jo-Watanabe; Saiko Kazuno; Takeshi Miyatsuka; Tadahiro Kitamura; Yoshio Fujitani; Hirotaka Watada; Kazuko Saeki; Takehiko Yokomizo, Oct. 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34, 10, 13949, 13958, Scientific journal

  DOI
• Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes., Masaki Kobayashi; Hiroaki Satoh; Toshihiro Matsuo; Yoshiki Kusunoki; Masahiko Tokushima; Hirotaka Watada; Mitsuyoshi Namba; Tadahiro Kitamura, 28 Sep. 2020, Endocrine journal, 67, 9, 903, 922, Scientific journal

  DOI
• Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling., Takayoshi Suga; Ken Sato; Tatsuya Ohyama; Sho Matsui; Takeshi Kobayashi; Hiroki Tojima; Norio Horiguchi; Yuichi Yamazaki; Satoru Kakizaki; Ayaka Nishikido; Takashi Okamura; Masanobu Yamada; Tadahiro Kitamura; Toshio Uraoka, 27 Jul. 2020, World journal of hepatology, 12, 7, 350, 362, Scientific journal

  DOI
• Dysfunction of BCAA Catabolism in Pancreatic Alpha Cells Is Associated with Higher Glucagon Secretion in Diabetic Mice, Eri Wada; Masaki Kobayashi; Osamu Kikuchi; Daisuke Kohno; Tadahiro Kitamura, Jun. 2020, DIABETES, 69

  DOI
• Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice., Daisuke Kohno; Kenichi Furusawa; Tadahiro Kitamura, 28 May 2020, Endocrine journal, 67, 5, 523, 529, Scientific journal

  DOI
• DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression., Masashi Kuroda; Rumi Onoyama; Waka Sasaki; Mayu Sebe; Tadahiro Kitamura; Saeko Masumoto; Rie Tsutsumi; Nagakatsu Harada; Hiroshi Sakaue, 16 Feb. 2020, Biochemical and biophysical research communications, 525, 1, 39, 45, Scientific journal

  DOI
• A Multicenter, Randomized Controlled Study of the Efficacy of Once-Weekly DPP-4 Inhibitor Omarigliptin in Patients with Type 2 Diabetes Undergoing Maintenance Hemodialysis, Yuta Yoshizawa; Michihiro Hosojima; Hideyuki Kabasawa; Naohito Tanabe; Tadahiro Kitamura; Ichiei Narita; Akihiko Saito, Jun. 2019, DIABETES, 68

  DOI
• Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness., Daisuke Kohno; Miho Koike; Yuzo Ninomiya; Itaru Kojima; Tadahiro Kitamura; Toshihiko Yada, 2016, Frontiers in neuroscience, 10, 502, 502, Scientific journal
• iNOS Activates GSK-3 beta and Thereby Decreases PDX1 Expression in Pancreatic beta-Cells: Role of beta-Catenin, Toshihiro Tanioka; Shohei Shinozaki; Yasuko Nakano; Tadahiro Kitamura; Masao Kaneki, Jun. 2015, DIABETES, 64, A13, A13
• [Significance of glucagon control in the diabetes treatment]., Tadahiro Kitamura, Mar. 2015, Nihon rinsho. Japanese journal of clinical medicine, 73, 3, 509, 16, Scientific journal
• iNOS Suppresses PDX1 Expression in Pancreatic beta-Cells: Role of GSK-3 beta/beta-Catenin Pathway, Toshihiro Tanioka; Yoshiaki Tamura; Nobuyuki Shimizu; Yasuko Nakano; Tadahiro Kitamura; Masao Kaneki, Jun. 2014, DIABETES, 63, A12, A12
• Testosterone Administration Reduced Adiposity and Elevated Mitochondria Biogenesis in Skeletal Muscle, Koichiro Taguchi; Kazuo Kajita; Taro Usui; Kei Fujioka; Ichiro Mori; Takayuki Hanamoto; Takahide Ikeda; Noriko Takahashi; Yoshihiko Kitada; Yoshihiro Uno; Hiroyuki Morita; Mayumi Shimpuku; Tsutomu Sasaki; Tadahiro Kitamura; Itaru Kojima; Tatsuo Ishizuka, Jul. 2013, DIABETES, 62, A532, A532
• [Obesity and the central regulation of energy metabolism]., Tadahiro Kitamura, Feb. 2013, Nihon rinsho. Japanese journal of clinical medicine, 71, 2, 217, 23, Scientific journal
• Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta., Toshihiro Tanioka; Yoshiaki Tamura; Makiko Fukaya; Shohei Shinozaki; Ji Mao; Minhye Kim; Nobuyuki Shimizu; Tadahiro Kitamura; Masao Kaneki, 19 Aug. 2011, The Journal of biological chemistry, 286, 33, 29388, 29396, Scientific journal

  DOI
• iNOS Promotes Proteasome-Dependent Degradation of IRS-2 and Suppresses PDX-1 Expression by Activating GSK-3 beta in Pancreatic beta-Cells, Toshihiro Tanioka; Yoshiaki Tamura; Makiko Fukaya; Tadahiro Kitamura; Masao Kaneki, Jul. 2011, DIABETES, 60, A79, A79
• [The roles of PPAR, C/EBP and FoxO families in adipocyte differentiation and proliferation]., Tadahiro Kitamura; Yukari Kitamura, Jan. 2011, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 1, 259, 63, Scientific journal
• Protection by S-Nitrosoglutathione Reductase (GSNOR), a Negative Regulator of S-Nitrosylation, Against Apoptosis: Regulation of PDX-1 in Pancreatic beta-Cells, Yoshiaki Tamura; Toshihiro Tanioka; Yuko Chiba; Makiko Fukaya; Tadahiro Kitamura; Hideki Ito; Jonathan S. Stamler; Masao Kaneki, Jun. 2010, DIABETES, 59, A49, A49
• iNOS Is Required for IL-1 beta-Induced Suppressed PDX-1 Expression, Inactivation of IRS-2/Akt Pathway and NF-kappa B Activation in Pancreatic beta-Cells, Toshihiro Tanioka; Yoshiaki Tamura; Makiko Fukaya; Shoheishi Shinozaki; Tadahiro Kitamura; Masao Kaneki, Jun. 2010, DIABETES, 59, A124, A124
• [Role of FoxO proteins in insulin signaling]., Tadahiro Kitamura, Aug. 2007, Seikagaku. The Journal of Japanese Biochemical Society, 79, 8, 785, 9, Scientific journal
• Mosaic analysis of insulin receptor function., Tadahiro Kitamura; Yukari Kitamura; Jun Nakae; Antonio Giordano; Saverio Cinti; C Ronald Kahn; Argiris Efstratiadis; Domenico Accili, Jan. 2004, The Journal of clinical investigation, 113, 2, 209, 19, Scientific journal
• Comprehensive efficacy of ipragliflozin on various conditioned type 2 diabetes compared with dipeptidyl peptidase-4 inhibitors and with both agents, based on a real-world multicenter trial, Fumio Sawano; Nozomu Kamei; Mitsue Miyahara; Kyoko Kobuke; Shuhei Nakanishi; Chihiro Nagano; Hideki Nojima; Shusaku Maeda; Hiroshi Watanabe; Rui Kishimoto; Mami Yamashita; Aya Hamaoka; Kana Mukai; Tomoko Tsuboi; Hisayoshi Mochizuki; Reiko Nakashima; Yu Sakashita; Hisaaki Morishita; Tadahiro Kitamura, Feb. 2021, DIABETOLOGY INTERNATIONAL, Scientific journal

  DOI
• SIRT1 SIGNALING MAY BE INVOLVED IN ATTENUATION OF LIVER STEATOSIS BY THE SGLT2 INHIBITOR IPRAGLIFLOZIN, Ken Sato; Takayoshi Suga; Tatsuya Ohyama; Sho Matsui; Takeshi Kobayashi; Hiroki Tojima; Norio Horiguchi; Yuichi Yamazaki; Satoru Kakizaki; Ayaka Nishikido; Takashi Okamura; Masanobu Yamada; Tadahiro Kitamura; Toshio Uraoka, Oct. 2019, HEPATOLOGY, 70, 1323A, 1323A
• Foxo1-CoF Repressor (FCoR) Regulates Pancreatic Alpha- and Beta-Cell Identity by both DNA and Histone Methylation, Noriko Kodani; Masaki Kobayashi; Osamu Kikuchi; Tadahiro Kitamura; Hiroshi Itoh; Jun Nakae, Jun. 2019, DIABETES, 68

  DOI
• SGLT1 in Pancreatic a Cells Regulates Glucagon Secretion in Mice, Possibly Explaining the Distinct Effects of SGLT2 Inhibitors on Plasma Glucagon Levels, Takayoshi Suga; Osamu Kikuchi; Masaki Kobayashi; Sho Matsui; Hiromi H. Hashimoto; Tsutomu Sasaki; Satoru Kakizaki; Masanobu Yamada; Tadahiro Kitamura, Jul. 2018, DIABETES, 67

  DOI
• Fox01 Regulates alpha-cell Mass through DNA Methylation of Arx Pro-moter Cooperated with Fox01 CoRepressor (FCoR), Noriko Kodani; Jun Nakae; Yoshinaga Kawano; Lisa Ohira; Tetsuhiro Kikuchi; Motoko Matsuzaki; Nobuko Goto; Ayako Shigeta; Kazumasa Yagi; Tadahiro Kitamura; Hiroshi Itoh, Jun. 2016, DIABETES, 65, A25, A25
• Foxo1 Corepressor (FCoR) Regulates alpha-Cell Mass via Epigenetic Regulation of Aristaless-related Homeobox (Arx) Gene, Noriko Kodani; Jun Nakae; Lisa Ohira; Yoshinaga Kawano; Tetsuhiro Kikuchi; Motoko Matsuzaki; Nobuko Goto; Ayako Shigeta; Tadahiro Kitamura; Hiroshi Itoh, Jun. 2015, DIABETES, 64, A65, A65
• Testosterone Upregulates Mitochondrial Biogenesis in Skeletal Muscle, Yoshihiko Kitada; Koichiro Taguchi; Taro Usui; Hideyuki Okada; Ichiro Mori; Takahide Ikeda; Kazuo Kajita; Tadahiro Kitamura; Tsutomu Sasaki; Takashi Sato; Tatsuo Ishizuka, Jun. 2014, DIABETES, 63, A500, A500
• Molecular mechanism by which DPP4 inhibitor suppresses glucagon secretion, Tadahiro Kitamura, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S92, S92
• Pomc-Cre; Sirt1 Conditional Knock-In Mice Present Lean Phenotype Due to Increased Energy Expenditure, Tsutomu Sasaki; Kosuke Amano; Tomoya Kitazumi; Osamu Kikuchi; Masaki Kobayashi; Tadahiro Kitamura, Jul. 2011, DIABETES, 60, A128, A128
• Protective Roles of S-Nitrosoglutathione Reductase (GSNOR), a Negative Regulator of Protein S-Nitrosylation, in Obesity- and Streptozotocin-Induced Diabetes: iNOS-Dependent and -Independent Mechanisms, Yuko Chiba; Makiko Fukaya; Michihiro Sakai; Shohei Shinozaki; Tadahiro Kitamura; Hideki Ito; Jonathan S. Stamler; Masao Kaneki, Jun. 2009, DIABETES, 58, A428, A428
• Regulation of Hepatic Glycolysis by FoxO1 Via ChREBP O-Glycosylation, Tadahiro Kitamura; Yukari Kitamura; Domenico Accili, Jun. 2009, DIABETES, 58, A93, A93
• FoxO1 plays important roles in pancreatic cell differentiation and cell type specification, Tadahiro Kitamura; Yukart Kitamura; Domenico Accili, Jun. 2008, DIABETES, 57, A1, A1
• Transcription factor FoxO1 controls skeletal muscle fiber type composition via interaction with notch signaling, Tadahiro Kitamura; Yukari Ido-Kitamura; Yasuhiro Funahashi; Carrie Shawber; Ronald Depinho; Jan Kitajewski; Domenico Accili, Jun. 2007, DIABETES, 56, A85, A85
• グルカゴン測定系の課題とアプローチ, 北村 忠弘, Oct. 2015, 26, 5, 545
• 糖尿病治療における消化管ホルモン(グルカゴン、インクレチン)の位置づけ　グルカゴン(α細胞)研究の最前線, 北村 忠弘, Apr. 2016, 92, 1, 134
• Sirt1はオキシトシンを介してショ糖嗜好性を抑制する, ;;;;, Apr. 2016, 92, 1, 202
• NMDA受容体コアゴニストD-セリンは食事嗜好性を制御する, ;;;, Apr. 2016, 92, 1, 246
• NMDA受容体コアゴニストD-セリンは食事嗜好性を制御する, ;;;, Dec. 2015, 88回・38回, [4T特
• Sirt1によるショ糖嗜好性制御機構の解明, ;;;;;, Sep. 2016, 22, Suppl., 172
• 視床下部FTOによる体重調節機構, ;;;, Sep. 2016, 22, Suppl., 204
• 高脂肪食性摂食リズム障害におけるミクログリアのギャップ結合の役割の解明, ;;;;, Sep. 2016, 22, Suppl., 207
• 【糖尿病研究の"いま"と治療の"これから"】(第1章)インスリン分泌低下はなぜ起きるのか?　グルカゴン分泌異常　その病態生理的意義, ;, Feb. 2017, 35, 2, 187
• Sirtuin研究の最前線　活性制御の分子基盤から疾患研究まで　SIRT1はFGF21-oxytocinを介してショ糖嗜好性を制御する, ;;, Sep. 2016, 89回, [1S09
• FGF21によるオキシトシン発現制御機構の解析, ;;;;;, Apr. 2017, 93, 1, 332
• グルカゴンの新規測定系開発および血糖変化に伴う分泌変動, ;;;;;;;;, Apr. 2017, 93, 1, 366
• 高脂肪食性摂食リズム障害におけるミクログリアのギャップ結合の役割の解明, ;;;;, Apr. 2017, 93, 1, 368
• 新規測定系で得られたグルカゴンの新知見, ;;;, Apr. 2017, 60, Suppl.1, S
• 新規開発測定系を用いた血糖変化に伴う血中グルカゴン変動の再検証, ;;;;;;;;, Apr. 2017, 60, Suppl.1, S
• サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, ;;;;;;;;, Apr. 2017, 60, Suppl.1, S
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, ;;;;, Apr. 2017, 60, Suppl.1, S
• Txnipはマウスにおいて先天性BAT熱産生機能を維持する(Txnip preserves innate BAT thermogenic function in mice), Zou Meng; 田部 勝也; 椎木 幾久子; 河野 大輔; 田口 昭彦; 奥屋 茂; 北村 忠弘; 増谷 弘; 谷澤 幸生, Apr. 2023, 糖尿病, 66, Suppl.1, S, 302
• Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders., Min Zhao; Katsuhide Okunishi; Yun Bu; Osamu Kikuchi; Hao Wang; Tadahiro Kitamura; Tetsuro Izumi, 22 Feb. 2023, JCI insight, 8, 4, Scientific journal

  DOI
• 【栄養・代謝物シグナルと食品機能 転写、エピゲノムの制御から代謝性疾患の治療・予防に向けて】(第3章)栄養・代謝物シグナル修飾および破綻と疾患 糖尿病病態における高グルカゴン血症と分岐鎖アミノ酸の関連, 和田 恵梨; 北村 忠弘, May 2022, 40, 7, 1168, 1174
• Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells, Norikiyo Honzawa; Kei Fujimoto; Masaki Kobayashi; Daisuke Kohno; Osamu Kikuchi; Hiromi Yokota-Hashimoto; Eri Wada; Yuichi Ikeuchi; Yoko Tabei; Gerald W. Dorn; Kazunori Utsunomiya; Rimei Nishimura; Tadahiro Kitamura, 04 Apr. 2022, International Journal of Molecular Sciences, 23, 7, 4003, 4003, Scientific journal

  DOI
• The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels., Yuri Kondo; Atsushi Ozawa; Daisuke Kohno; Kazuma Saito; Battsetseg Buyandalai; Sayaka Yamada; Kazuhiko Horiguchi; Yasuyo Nakajima; Nobuyuki Shibusawa; Akihiro Harada; Hideaki Yokoo; Hideo Akiyama; Tsutomu Sasaki; Tadahiro Kitamura; Masanobu Yamada, Jan. 2022, Thyroid : official journal of the American Thyroid Association, 32, 1, 105, 114, Scientific journal

  DOI
• Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, Atsushi Morio; Rie Tsutsumi; Shiho Satomi; Takashi Kondo; Hirotsugu Miyoshi; Takahiro Kato; Masashi Kuroda; Tadahiro Kitamura; Kenta Hara; Noboru Saeki; Hiroshi Sakaue; Yasuo M. Tsutsumi, Dec. 2021, Diabetology and Metabolic Syndrome, 13, 1, Scientific journal

  DOI
• Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model., Atsushi Morio; Rie Tsutsumi; Shiho Satomi; Takashi Kondo; Hirotsugu Miyoshi; Takahiro Kato; Masashi Kuroda; Tadahiro Kitamura; Kenta Hara; Noboru Saeki; Hiroshi Sakaue; Yasuo M Tsutsumi, 20 Nov. 2021, Diabetology & metabolic syndrome, 13, 1, 139, 139, Scientific journal

  DOI
• Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice., Eri Wada; Masaki Kobayashi; Daisuke Kohno; Osamu Kikuchi; Takayoshi Suga; Sho Matsui; Hiromi Yokota-Hashimoto; Norikiyo Honzawa; Yuichi Ikeuchi; Haruka Tsuneoka; Touko Hirano; Hideru Obinata; Tsutomu Sasaki; Tadahiro Kitamura, Nov. 2021, The Journal of nutritional biochemistry, 97, 108811, 108811, Scientific journal

  DOI
• Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling., Atsushi Morio; Rie Tsutsumi; Takashi Kondo; Hirotsugu Miyoshi; Takahiro Kato; Soshi Narasaki; Shiho Satomi; Erika Nakaya; Masashi Kuroda; Hiroshi Sakaue; Tadahiro Kitamura; Yasuo M Tsutsumi, 22 Sep. 2021, Nutrition, metabolism, and cardiovascular diseases : NMCD, 31, 10, 2979, 2986, Scientific journal

  DOI
• Measurement of Plasma Glucagon Levels Using Mass Spectrometry in Patients with Type 2 Diabetes on Maintenance Hemodialysis., Yuta Yoshizawa; Michihiro Hosojima; Hideyuki Kabasawa; Naohito Tanabe; Atsushi Miyachi; Hitoshi Hamajima; Eri Mieno; Masaki Kobayashi; Tadahiro Kitamura; Ichiei Narita; Akihiko Saito, 17 Aug. 2021, Kidney & blood pressure research, 46, 5, 1, 5, Scientific journal

  DOI
• 膵α細胞における分岐鎖アミノ酸代謝異常は糖尿病のグルカゴン過剰分泌に関与する, 和田 恵梨; 小林 雅樹; 河野 大輔; 菊池 司; 平野 瞳子; 大日方 英; 北村 忠弘, May 2021, 64, Suppl.1, YIA, 2)
• グルカゴンによるタンパク質嗜好性制御機構の解明, 松居 翔; 中川 祐子; 藤谷 与士夫; 北村 忠弘; 佐々木 努, Mar. 2021, 14, 1, 49, 49
• グルカゴンシグナルによる膵PP細胞の過形成のメカニズムの解明, 中川 祐子; 林 良敬; 北村 忠弘; 堀居 拓郎; 畑田 出穂; 藤谷 与士夫, Aug. 2020, 63, Suppl.1, S, 257
• 糖尿病病態で分岐鎖アミノ酸摂取がグルカゴン分泌に与える意義の解明, 和田 恵梨; 小林 雅樹; 河野 大輔; 北村 忠弘, Jan. 2020, 23, Suppl., S, 2
• プレプログルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, 中川 祐子; 林 良敬; 北村 忠弘; 藤谷 与士夫, Apr. 2019, 62, Suppl.1, S, 310
• 糖尿病病態での分岐鎖アミノ酸に対するグルカゴン分泌応答障害の検証, 和田 恵梨; 小林 雅樹; 河野 大輔; 菊池 司; 須賀 孝慶; 松居 翔; 佐々木 努; 北村 忠弘, Apr. 2019, 62, Suppl.1, S, 256
• 糖尿病病態におけるアミノ酸のグルカゴン分泌亢進作用, 和田 恵梨; 小林 雅樹; 河野 大輔; 菊池 司; 須賀 孝慶; 松居 翔; 佐々木 努; 北村 忠弘, Jan. 2019, 22, Suppl., S, 1
• SGLT-2阻害薬によるグルカゴン分泌調節機構, 須賀 孝慶; 菊池 司; 小林 雅樹; 松居 翔; 橋本 博美; 河野 大輔; 佐々木 努; 竹内 一翔; 串田 祥; 山田 正信; 北村 忠弘, Apr. 2018, 61, Suppl.1, S, 232
• 糖尿病病態での摂取栄養素に対するグルカゴン分泌応答異常の検証, 和田 恵梨; 小林 雅樹; 菊池 司; 須賀 孝慶; 松居 翔; 河野 大輔; 佐々木 努; 竹内 一翔; 串田 祥; 北村 忠弘, Apr. 2018, 61, Suppl.1, S, 317
• 栄養素によるグルカゴン分泌調節機構と糖尿病での破綻機序の解明, 和田 恵梨; 小林 雅樹; 菊池 司; 竹内 一翔; 串田 祥; 北村 忠弘, Jan. 2018, 21, Suppl., S, 116
• 食欲・食嗜好の分子・神経基盤 脳SIRT1による栄養素に基づいた食選択行動の制御メカニズム, 佐々木 努; 松居 翔; 河野 大輔; 北村 忠弘, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [4AW08, 4]
• 新規高特異性サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, 須賀 孝慶; 小林 雅樹; 菊池 司; 松居 翔; 橋本 博美; 河野 大輔; 佐々木 努; 山田 正信; 北村 忠弘, Apr. 2016, 59, Suppl.1, S, 275
• Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B, Hiroshi Takaishi; Hiroaki Konishi; Hidenori Matsuzaki; Yoshitaka Ono; Yasuhito Shirai; Naoaki Saito; Tadahiro Kitamura; Wataru Ogawa; Masato Kasuga; Ushio Kikkawa; Yasutomi Nishizuka, 12 Oct. 1999, Proceedings of the National Academy of Sciences of the United States of America, 96, 21, 11836, 11841, Scientific journal

  DOI
• Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt, Tadahiro Kitamura; Yukari Kitamura; Shoji Kuroda; Yasuhisa Hino; Miwa Ando; K. O. Kotani; Hiroaki Konishi; Hidenori Matsuzaki; Ushio Kikkawa; Wataru Ogawa; Masato Kasuga, Sep. 1999, Molecular and Cellular Biology, 19, 9, 6286, 6296, Scientific journal

  DOI
• Requirement of the serine-threonine kinase Akt for heat treatment-induced activation of p70 S6 kinase, Shoji Kuroda; Wataru Ogawa; Tadahiro Kitamura; Hiroaki Konishi; Ushio Kikkawa; Masato Kasuga, 28 Aug. 1998, Biochemical and Biophysical Research Communications, 249, 3, 781, 785, Scientific journal

  DOI
• Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP, Sasaki, Tsutomu;Kim, Hye-jin;Kobayashi, Masaki;Kitamura, Yukari-Ido;Yokota-Hashimoto, Hiromi;Shiuchi, Tetsuya;Minokoshi, Yasuhiko;Kitamura, Tadahiro, 2010, NEUROSCIENCE RESEARCH, 68, E77, E77

  DOI
• Protection Against High-Fat Diet Induced Obesity in Helz2-Deficient Male Mice Due to Enhanced Expression of Hepatic Leptin Receptof, Satoh, Tetsurou;Yoshino, Satoshi;Yamada, Masanobu;Hashimoto, Koshi;Tomaru, Takuya;Katano-Toki, Akiko;Okada, Shuichi;Ozawa, Atsushi;Ishii, Sumiyasu;Horiguchi, Kazuhiko;Shibusawa, Nobuyuki;Sasaki, Tsutomu;Kitamura, Tadahiro;Mori, Masatomo, 2014, ENDOCRINE REVIEWS, 35, 3
• Role of FoxO proteins in the insulin signaling, Kitamura, Tadahiro, 2007, SEIKAGAKU, 79, 8, 785, 789
• A Foxo/Notch pathway controls myogenic differentiation and fiber type specification, Kitamura, Tadahiro;Kitamura, Yukari Ido;Funahashi, Yasuhiro;Shawber, Carrie J.;Castrillon, Diego H.;Kollipara, Ramya;DePinho, Ronald A.;Kitajewski, Jan;Accili, Domenico, 2007, JOURNAL OF CLINICAL INVESTIGATION, 117, 9, 2477, 2485

  DOI
• Role of FoxO proteins in pancreatic β cells, Kitamura, Tadahiro;Kitamura, Yukari Ido, 2007, ENDOCRINE JOURNAL, 54, 4, 507, 515
• The Transcription Factor COUP-TFII Is Negatively Regulated by Insulin and Glucose via Foxo1-and ChREBP-Controlled Pathways, Perilhou, Anais;Tourrel-Cuzin, Cecile;Kharroubi, Ilham;Henique, Carole;Fauveau, Veronique;Kitamura, Tadahiro;Magnan, Christophe;Postic, Catherine;Prip-Buus, Carina;Vasseur-Cognet, Mireille, 2008, MOLECULAR AND CELLULAR BIOLOGY, 28, 21, 6568, 6579

  DOI
• Expression of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 in Pancreatic β-Cells and Its Role in Promotion of Insulin Secretion and Protection against Diabetes, Kobayashi, Masaki;Ohnishi, Hiroshi;Okazawa, Hideki;Murata, Yoji;Hayashi, Yuriko;Kobayashi, Hisae;Kitamura, Tadahiro;Matozaki, Takashi, 2008, ENDOCRINOLOGY, 149, 11, 5662, 5669

  DOI
• Dicer Is Required for Maintaining Adult Pancreas, Morita, Sumiyo;Hara, Akemi;Kojima, Itaru;Horii, Takuro;Kimura, Mika;Kitamura, Tadahiro;Ochiya, Takahiro;Nakanishi, Katsumi;Matoba, Ryo;Matsubara, Kenichi;Hatada, Izuho, 2009, PLOS ONE, 4, 1

  DOI
• Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1, Kitamura, Tadahiro;Kitamura, Yukari Ido;Kobayashi, Masaki;Kikuchi, Osamu;Sasaki, Tsutomu;DePinho, Ronald A.;Accili, Domenico, 2009, MOLECULAR AND CELLULAR BIOLOGY, 29, 16, 4417, 4430

  DOI
• Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells, Tanaka, Jun;Qiang, Li;Banks, Alexander S.;Welch, Carrie L.;Matsumoto, Michihiro;Kitamura, Tadahiro;Ido-Kitamura, Yukari;DePinho, Ronald A.;Accili, Domenico, 2009, DIABETES, 58, 10, 2344, 2354

  DOI
• The roles of FoxO1 and Sirt1 in the regulation of food intake, Kitamura, Tadahiro;Sasaki, Tsutomu;Kitamura, Yukari, 2009, NEUROSCIENCE RESEARCH, 65, S11, S11

  DOI
• The cathepsin L gene is a direct target of FOXO1 in skeletal muscle, Yamazaki, Yoshihiro;Kamei, Yasutomi;Sugita, Satoshi;Akaike, Fumiko;Kanai, Sayaka;Miura, Shinji;Hirata, Yukio;Troen, Bruce R.;Kitamura, Tadahiro;Nishino, Ichizo;Suganami, Takayoshi;Ezaki, Osamu;Ogawa, Yoshihiro, 2010, BIOCHEMICAL JOURNAL, 427, 171, 178

  DOI
• Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide, Sasaki, Tsutomu;Kim, Hye-Jin;Kobayashi, Masaki;Kitamura, Yukari-Ido;Yokota-Hashimoto, Hiromi;Shiuchi, Tetsuya;Minokoshi, Yasuhiko;Kitamura, Tadahiro, 2010, ENDOCRINOLOGY, 151, 6, 2556, 2566

  DOI
• The roles of FoxO1 and Sirt1 in pancreas and hypothalamus, Kitamura, Tadahiro;Sasaki, Tsutomu;Kobayashi, Masaki;Kim, Hye-Jin;Kitamura, Yukari, 2010, ENDOCRINE JOURNAL, 57, S302, S302
• The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle, Yamazaki, Yoshihiro;Kamei, Yasutomi;Sugita, Satoshi;Akaike, Fumiko;Kanai, Sayaka;Miura, Shinji;Hirata, Yukio;Troen, Bruce R.;Kitamura, Tadahiro;Nishino, Ichizo;Suganami, Takayoshi;Ezaki, Osamu;Ogawa, Yoshihiro, 2010, ENDOCRINE JOURNAL, 57, S350, S350
• Induction of hypothalamic Sirt1 leads to cessation of feeding via AgRP, Sasaki, Tsutomu;Kim, Hye-Jin;Kobayashi, Masaki;Kitamura, Yukari-Ido;Yokota-Hashimoto, Hiromi;Shiuchi, Tetsuya;Minokoshi, Yasuhiko;Kitamura, Tadahiro, 2010, ENDOCRINE JOURNAL, 57, S353, S353
• Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms, Kaneko, Kazuma;Ueki, Kohjiro;Takahashi, Noriko;Hashimoto, Shinji;Okamoto, Masayuki;Awazawa, Motoharu;Okazaki, Yukiko;Ohsugi, Mitsuru;Inabe, Kazunori;Umehara, Toshihiro;Yoshida, Masashi;Kakei, Masafumi;Kitamura, Tadahiro;Luo, Ji;Kulkarni, Rohit N.;Kahn, C. Ronald;Kasai, Haruo;Cantley, Lewis C.;Kadowaki, Takashi, 2010, CELL METABOLISM, 12, 6, 619, 632

  DOI
• Roles of FoxO1 and Sirt1 in the central regulation of food intake, Sasaki, Tsutomu;Kitamura, Tadahiro, 2010, ENDOCRINE JOURNAL, 57, 11, 939, 946
• Inducible Nitric-oxide Synthase and Nitric Oxide Donor Decrease Insulin Receptor Substrate-2 Protein Expression by Promoting Proteasome-dependent Degradation in Pancreatic β-Cells INVOLVEMENT OF GLYCOGEN SYNTHASE KINASE-3β, Tanioka, Toshihiro;Tamura, Yoshiaki;Fukaya, Makiko;Shinozaki, Shohei;Mao, Ji;Kim, Minhye;Shimizu, Nobuyuki;Kitamura, Tadahiro;Kaneki, Masao, 2011, JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 33, 29388, 29396

  DOI
• Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance, Kim, Hye-Jin;Kobayashi, Masaki;Sasaki, Tsutomu;Kikuchi, Osamu;Amano, Kosuke;Kitazumi, Tomoya;Lee, Yong-Soo;Yokota-Hashimoto, Hiromi;Susanti, Vina Yanti;Kitamura, Yukari Ido;Nakae, Jun;Kitamura, Tadahiro, 2012, ENDOCRINOLOGY, 153, 2, 659, 671

  DOI
• FoxO1 as a double-edged sword in the pancreas: analysis of pancreas-and β-cell-specific FoxO1 knockout mice, Kobayashi, Masaki;Kikuchi, Osamu;Sasaki, Tsutomu;Kim, Hye-Jin;Yokota-Hashimoto, Hiromi;Lee, Yong-Soo;Amano, Kosuke;Kitazumi, Tomoya;Susanti, Vina Yanti;Kitamura, Yukari Ido;Kitamura, Tadahiro, 2012, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302, 5, E603, E613

  DOI
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation, Talchai, Chutima;Xuan, Shouhong;Kitamura, Tadahiro;DePinho, Ronald A.;Accili, Domenico, 2012, NATURE GENETICS, 44, 4, 406, U213

  DOI
• FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization, Kikuchi, Osamu;Kobayashi, Masaki;Amano, Kosuke;Sasaki, Tsutomu;Kitazumi, Tomoya;Kim, Hye-Jin;Lee, Yong-Soo;Yokota-Hashimoto, Hiromi;Kitamura, Yukari-Ido;Kitamura, Tadahiro, 2012, PLOS ONE, 7, 2

  DOI
• Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis, Hasegawa, Koichi;Kawahara, Tomohiro;Fujiwara, Kazushiro;Shimpuku, Mayumi;Sasaki, Tsutomu;Kitamura, Tadahiro;Yoshikawa, Kazuaki, 2012, JOURNAL OF NEUROSCIENCE, 32, 16, 5562, 5572

  DOI
• Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion, Nakakura, Takashi;Mogi, Chihiro;Tobo, Masayuki;Tomura, Hideaki;Sato, Koichi;Kobayashi, Masaki;Ohnishi, Hiroshi;Tanaka, Shigeyasu;Wayama, Mitsutoshi;Sugiyama, Tetsuya;Kitamura, Tadahiro;Harada, Akihiro;Okajima, Fumikazu, 2012, ENDOCRINOLOGY, 153, 9, 4171, 4180

  DOI
• Induction of Sirt1 expression in the murine hypothalamic AgRP and Pomc neurons leads to lean phenotype due to decreased food intake and increased energy expenditure, Sasaki, Tsutomu;Kitazumi, Tomoya;Amano, Kousuke;Kikuchi, Osamu;Hashimoto, Hiromi;Kobayashi, Masaki;Kitamura, Tadahiro, 2011, NEUROSCIENCE RESEARCH, 71, E62, E62

  DOI
• Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation, Ido-Kitamura, Yukari;Sasaki, Tsutomu;Kobayashi, Masaki;Kim, Hye-Jin;Lee, Yong-Soo;Kikuchi, Osamu;Yokota-Hashimoto, Hiromi;Iizuka, Katsumi;Accili, Domenico;Kitamura, Tadahiro, 2012, PLOS ONE, 7, 10

  DOI
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells, Masubuchi, Yosuke;Nakagawa, Yuko;Ma, Jinhui;Sasaki, Tsutomu;Kitamura, Tadahiro;Yamamoto, Yoritsuna;Kurose, Hitoshi;Kojima, Itaru;Shibata, Hiroshi, 2013, PLOS ONE, 8, 1

  DOI
• Hypothalamic Sirt1 overexpression leads to a negative energy balance, Sasaki, Tsutomu;Shimpuku, Mayumi;Kikuchi, Osamu;Susanti, Vina Yanti;Yokota-Hashimoto, Hiromi;Kobayashi, Masaki;Kitamura, Tadahiro, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S58, S58
• Molecular mechanism by which DPP4 inhibitor suppresses glucagon secretion, Kitamura, Tadahiro, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S92, S92
• The role of FOXO1 in β-cell failure and type 2 diabetes mellitus, Kitamura, Tadahiro, 2013, NATURE REVIEWS ENDOCRINOLOGY, 9, 10, 615, 623

  DOI
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Sasaki, Tsutomu;Shimpuku, Mayumi;Kitazumi, Tomoya;Hiraga, Haruna;Nakagawa, Yuko;Shibata, Hiroshi;Okamatsu-Ogura, Yuko;Kikuchi, Osamu;Kim, Hye-jin;Fujita, Yuki;Maruyama, Jun;Susanti, Vina Yanti;Yokota-Hashimoto, Hiromi;Kobayashi, Masaki;Saito, Masayuki;Kitamura, Tadahiro, 2013, ENDOCRINE JOURNAL, 60, 10, 1117, 1129
• A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting, Syamsunarno, Mas Rizky A. A.;Iso, Tatsuya;Hanaoka, Hirofumi;Yamaguchi, Aiko;Obokata, Masaru;Koitabashi, Norimichi;Goto, Kosaku;Hishiki, Takako;Nagahata, Yoshiko;Matsui, Hiroki;Sano, Motoaki;Kobayashi, Masaki;Kikuchi, Osamu;Sasaki, Tsutomu;Maeda, Kazuhisa;Murakami, Masami;Kitamura, Tadahiro;Suematsu, Makoto;Tsushima, Yoshito;Endo, Keigo;Hotamisligil, Goekhan S.;Kurabayashi, Masahiko, 2013, PLOS ONE, 8, 11

  DOI
• Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice, Fukaya, Makiko;Tamura, Yoshiaki;Chiba, Yuko;Tanioka, Toshihiro;Mao, Ji;Inoue, Yoko;Yamada, Marina;Waeber, Christian;Ido-Kitamura, Yukari;Kitamura, Tadahiro;Kaneki, Masao, 2013, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 442, 1-2, 92, 98

  DOI
• TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass, Takamoto, Iseki;Kubota, Naoto;Nakaya, Keizo;Kumagai, Katsuyoshi;Hashimoto, Shinji;Kubota, Tetsuya;Inoue, Mariko;Kajiwara, Eiji;Katsuyama, Hisayuki;Obata, Atsushi;Sakurai, Yoshitaka;Iwamoto, Masahiko;Kitamura, Tadahiro;Ueki, Kohjiro;Kadowaki, Takashi, 2014, DIABETOLOGIA, 57, 3, 542, 553

  DOI
• ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription, Lee, Yong-Soo;Kobayashi, Masaki;Kikuchi, Osamu;Sasaki, Tsutomu;Yokota-Hashimoto, Hiromi;Susanti, Vina Yanti;Kitamura, Yukari Ido;Kitamura, Tadahiro, 2014, ENDOCRINE JOURNAL, 61, 1, 85, 90
• Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice, Sasaki, Tsutomu;Kikuchi, Osamu;Shimpuku, Mayumi;Susanti, Vina Yanti;Yokota-Hashimoto, Hiromi;Taguchi, Ryo;Shibusawa, Nobuyuki;Sato, Takashi;Tang, Lijun;Amano, Kosuke;Kitazumi, Tomoya;Kuroko, Mitsutaka;Fujita, Yuki;Maruyama, Jun;Lee, Yong-soo;Kobayashi, Masaki;Nakagawa, Takashi;Minokoshi, Yasuhiko;Harada, Akihiro;Yamada, Masanobu;Kitamura, Tadahiro, 2014, DIABETOLOGIA, 57, 4, 819, 831

  DOI
• Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice, Usui, Taro;Kajita, Kazuo;Kajita, Toshiko;Mori, Ichiro;Hanamoto, Takayuki;Ikeda, Takahide;Okada, Hideyuki;Taguchi, Koichiro;Kitada, Yoshihiko;Morita, Hiroyuki;Sasaki, Tsutomu;Kitamura, Tadahiro;Sato, Takashi;Kojima, Itaru;Ishizuka, Tatsuo, 2014, FEBS LETTERS, 588, 10, 1935, 1941

  DOI
• Protection Against High-Fat Diet-Induced Obesity in Helz2-Deficient Male Mice Due to Enhanced Expression of Hepatic Leptin Receptor, Yoshino, Satoshi;Satoh, Tetsurou;Yamada, Masanobu;Hashimoto, Koshi;Tomaru, Takuya;Katano-Toki, Akiko;Kakizaki, Satoru;Okada, Shuichi;Shimizu, Hiroyuki;Ozawa, Atsushi;Tuchiya, Takafumi;Ikota, Hayato;Nakazato, Yoichi;Mori, Munemasa;Matozaki, Takashi;Sasaki, Tsutomu;Kitamura, Tadahiro;Mori, Masatomo, 2014, ENDOCRINOLOGY, 155, 9, 3459, 3472

  DOI
• FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3′-UTR: possible contribution to ammonia detoxification, Kamei, Yasutomi;Hattori, Maki;Hatazawa, Yukino;Kasahara, Tomomi;Kanou, Masanobu;Kanai, Sayaka;Yuan, Xunmei;Suganami, Takayoshi;Lamers, Wouter H.;Kitamura, Tadahiro;Ogawa, Yoshihiro, 2014, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 307, 6, E485, E493

  DOI
• Sirt1 Rescues the Obesity Induced by Insulin-Resistant Constitutively-Nuclear FoxO1 in POMC Neurons of Male Mice, Susanti, Vina Yanti;Sasaki, Tsutomu;Yokota-Hashimoto, Hiromi;Matsui, Sho;Lee, Yong-Soo;Kikuchi, Osamu;Shimpuku, Mayumi;Kim, Hye-Jin;Kobayashi, Masaki;Kitamura, Tadahiro, 2014, OBESITY, 22, 10, 2115, 2119

  DOI
• Dnmt3a in Sim1 Neurons Is Necessary for Normal Energy Homeostasis, Kohno, Daisuke;Lee, Syann;Harper, Matthew J.;Kim, Ki Woo;Sone, Hideyuki;Sasaki, Tsutomu;Kitamura, Tadahiro;Fan, Guoping;Elmquist, Joel K., 2014, JOURNAL OF NEUROSCIENCE, 34, 46, 15288, 15296

  DOI
• A Mutant Allele Encoding DNA Binding-Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism, Cook, Joshua R.;Matsumoto, Michihiro;Banks, Alexander S.;Kitamura, Tadahiro;Tsuchiya, Kyoichiro;Accili, Domenico, 2015, DIABETES, 64, 6, 1951, 1965

  DOI
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue, Sasaki, Tsutomu;Hiraga, Haruna;Yokota-Hashimoto, Hiromi;Kitamura, Tadahiro, 2015, ENDOCRINE JOURNAL, 62, 5, 469, 473
• N-methyl-D-aspartate receptor coagonist D-serine suppresses intake of high-preference food, Sasaki, Tsutomu;Kinoshita, Yoshihiro;Matsui, Sho;Kakuta, Shigeru;Yokota-Hashimoto, Hiromi;Kinoshita, Kuni;Iwasaki, Yusaku;Kinoshita, Toshio;Yada, Toshihiko;Amano, Naoji;Kitamura, Tadahiro, 2015, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309, 5, R561, R575

  DOI
• Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice, Sasaki, Tsutomu;Kuroko, Mitsutaka;Sekine, Sawako;Matsui, Sho;Kikuchi, Osamu;Susanti, Vina Yanti;Kobayashi, Masaki;Tanaka, Yoshinori;Yuasa, Tomoyuki;Kitamura, Tadahiro, 2015, ENDOCRINE JOURNAL, 62, 9, 787, 796
• Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigenrelated Cell Adhesion Molecule 2 (CEACAM2), Ghanem, Simona S.;Heinrich, Garrett;Lester, Sumona G.;Pfeiffer, Verena;Bhattacharya, Sumit;Patel, Payal R.;DeAngelis, Anthony M.;Dai, Tong;Ramakrishnan, Sadeesh K.;Smiley, Zachary N.;Jung, Dae Y.;Lee, Yongjin;Kitamura, Tadahiro;Ergun, Suleyman;Kulkarni, Rohit N.;Kim, Jason K.;Giovannucci, David R.;Najjar, Sonia M., 2016, JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 2, 980, 988

  DOI
• DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes, Kuroda, Masashi;Tominaga, Ayako;Nakagawa, Kasumi;Nishiguchi, Misa;Sebe, Mayu;Miyatake, Yumiko;Kitamura, Tadahiro;Tsutsumi, Rie;Harada, Nagakatsu;Nakaya, Yutaka;Sakaue, Hiroshi, 2016, PLOS ONE, 11, 8

  DOI
• Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine, Sasaki, Tsutomu;Matsui, Sho;Kitamura, Tadahiro, 2016, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17, 7

  DOI
• Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells, Kunii, Masataka;Ohara-Imaizumi, Mica;Takahashi, Noriko;Kobayashi, Masaki;Kawakami, Ryosuke;Kondoh, Yasumitsu;Shimizu, Takeshi;Simizu, Siro;Lin, Bangzhong;Nunomura, Kazuto;Aoyagi, Kyota;Ohno, Mitsuyo;Ohmuraya, Masaki;Sato, Takashi;Yoshimura, Shin-ichiro;Sato, Ken;Harada, Reiko;Kim, Yoon-Jeong;Osada, Hiroyuki;Nemoto, Tomomi;Kasai, Haruo;Kitamura, Tadahiro;Nagamatsu, Shinya;Harada, Akihiro, 2016, JOURNAL OF CELL BIOLOGY, 215, 1, 121, 138

  DOI
• Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness, Kohno, Daisuke;Koike, Miho;Ninomiya, Yuzo;Kojima, Itaru;Kitamura, Tadahiro;Yada, Toshihiko, 2016, FRONTIERS IN NEUROSCIENCE, 10

  DOI
• Intracerebroventricular injection of ghrelin decreases wheel running activity in rats, Miyatake, Yumiko;Shiuchi, Tetsuya;Mawatari, Kazuaki;Toda, Satomi;Taniguchi, Yasuko;Futami, Akari;Sato, Fukiko;Kuroda, Masashi;Sebe, Mayu;Tsutsumi, Rie;Harada, Nagakatsu;Minokoshi, Yasuhiko;Kitamura, Tadahiro;Gotoh, Koro;Ueno, Masaki;Nakaya, Yutaka;Sakaue, Hiroshi, 2017, PEPTIDES, 87, 12, 19

  DOI
• Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression, Fukunaka, Ayako;Fukada, Toshiyuki;Bhin, Jinhyuk;Suzuki, Luka;Tsuzuki, Takamasa;Takamine, Yuri;Bin, Bum-Ho;Yoshihara, Toshinori;Ichinoseki-Sekine, Noriko;Naito, Hisashi;Miyatsuka, Takeshi;Takamiya, Shinzaburo;Sasaki, Tsutomu;Inagaki, Takeshi;Kitamura, Tadahiro;Kajimura, Shingo;Watada, Hirotaka;Fujitani, Yoshio, 2017, PLOS GENETICS, 13, 8

  DOI
• Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: comparison with commercially available immunoassays, Miyachi, Atsushi;Kobayashi, Masaki;Mieno, Eri;Goto, Moritaka;Furusawa, Kenichi;Inagaki, Takashi;Kitamura, Tadahiro, 2017, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409, 25, 5911, 5918

  DOI
• Intraperitoneal injection of D-serine inhibits high-fat diet intake and preference in male mice, Sasaki, Tsutomu;Yasoshima, Yasunobu;Matsui, Sho;Yokota-Hashimoto, Hiromi;Kobayashi, Masaki;Kitamura, Tadahiro, 2017, APPETITE, 118, 120, 128

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Enomoto, Rina;Kurosawa, Aya;Nikaido, Yoshiaki;Mashiko, Misaki;Saheki, Toshihiko;Nakajima, Nozomi;Kuroiwa, Satoshi;Otobe, Michinari;Ohsaki, Maki;Tooyama, Kazuya;Inoue, Yusuke;Kuwabara, Nobuo;Kikuchi, Osamu;Kitamura, Tadahiro;Kojima, Itaru;Nakagawa, Yuko;Saito, Tamio;Osada, Hiroyuki;Futahashi, Mizuko;Sezutsu, Hideki;Takeda, Shigeki, 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• Role of novel variants of PGC-1α in the pathogenesis of obesity, Nomura, Kazuhiro;Hosooka, Tetsuya;Sasaki, Tsutomu;Kitamura, Tadahiro;Sakaue, Hiroshi;Kasuga, Masato;Ogawa, Wataru, 2016, DIABETES RESEARCH AND CLINICAL PRACTICE, 120, S191, S191
• ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption, Kato, Takehiro;Iizuka, Katsumi;Takao, Ken;Horikawa, Yukio;Kitamura, Tadahiro;Takeda, Jun, 2018, NUTRIENTS, 10, 3

  DOI
• The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells, Torii, Seiji;Kubota, Chisato;Saito, Naoya;Kawano, Ayumi;Hou, Ni;Kobayashi, Masaki;Torii, Ryoko;Hosaka, Masahiro;Kitamura, Tadahiro;Takeuchi, Toshiyuki;Gomi, Hiroshi, 2018, JOURNAL OF BIOLOGICAL CHEMISTRY, 293, 16, 5920, 5933

  DOI
• A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice, Sasaki, Tsutomu;Numano, Rika;Yokota-Hashimoto, Hiromi;Matsui, Sho;Kimura, Naobumi;Takeuchi, Hideyuki;Kitamura, Tadahiro, 2018, MOLECULAR BRAIN, 11

  DOI
• Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance, Gulshan, Maryam;Yaku, Keisuke;Okabe, Keisuke;Mahmood, Arshad;Sasaki, Tsutomu;Yamamoto, Masashi;Hikosaka, Keisuke;Usui, Isao;Kitamura, Tadahiro;Tobe, Kazuyuki;Nakagawa, Takashi, 2018, AGING CELL, 17, 4

  DOI
• Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice, Matsui, Sho;Sasaki, Tsutomu;Kohno, Daisuke;Yaku, Keisuke;Inutsuka, Ayumu;Yokota-Hashimoto, Hiromi;Kikuchi, Osamu;Suga, Takayoshi;Kobayashi, Masaki;Yamanaka, Akihiro;Harada, Akihiro;Nakagawa, Takashi;Onaka, Tatsushi;Kitamura, Tadahiro, 2018, NATURE COMMUNICATIONS, 9

  DOI
• SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels, Suga, Takayoshi;Kikuchi, Osamu;Kobayashi, Masaki;Matsui, Sho;Yokota-Hashimoto, Hiromi;Wada, Eri;Kohno, Daisuke;Sasaki, Tsutomu;Takeuchi, Kazusane;Kakizaki, Satoru;Yamada, Masanobu;Kitamura, Tadahiro, 2019, MOLECULAR METABOLISM, 19, 1, 12

  DOI
• Cell Autonomous Dysfunction and Insulin Resistance in Pancreatic α Cells, Honzawa, Norikiyo;Fujimoto, Kei;Kitamura, Tadahiro, 2019, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20, 15

  DOI
• Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes, Ichikawa, Raishi;Takano, Koji;Fujimoto, Kazumi;Motomiya, Tetsuya;Kobayashi, Masaki;Kitamura, Tadahiro;Shichiri, Masayoshi, 2019, ENDOCRINE JOURNAL, 66, 8, 663, 675

  DOI
• SIRT1 SIGNALING MAY BE INVOLVED IN ATTENUATION OF LIVER STEATOSIS BY THE SGLT2 INHIBITOR IPRAGLIFLOZIN, Sato, Ken;Suga, Takayoshi;Ohyama, Tatsuya;Matsui, Sho;Kobayashi, Takeshi;Tojima, Hiroki;Horiguchi, Norio;Yamazaki, Yuichi;Kakizaki, Satoru;Nishikido, Ayaka;Okamura, Takashi;Yamada, Masanobu;Kitamura, Tadahiro;Uraoka, Toshio, 2019, HEPATOLOGY, 70, 1323A, 1323A
• Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice, Inaba, Yuka;Hashiuchi, Emi;Watanabe, Hitoshi;Kimura, Kumi;Sato, Makoto;Kobayashi, Masaki;Matsumoto, Michihiro;Kitamura, Tadahiro;Kasuga, Masato;Inoue, Hiroshi, 2019, ENDOCRINOLOGY, 160, 12, 2811, 2824

  DOI
• FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression, Kodani, Noriko;Nakae, Jun;Kobayashi, Masaki;Kikuchi, Osamu;Kitamura, Tadahiro;Itoh, Hiroshi, 2020, ISCIENCE, 23, 1

  DOI
• DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression, Kuroda, Masashi;Onoyama, Rumi;Sasaki, Waka;Sebe, Mayu;Kitamura, Tadahiro;Masumoto, Saeko;Tsutsumi, Rie;Harada, Nagakatsu;Sakaue, Hiroshi, 2020, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 525, 1, 39, 45

  DOI
• The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B₄ axis, Hosooka, Tetsuya;Hosokawa, Yusei;Matsugi, Kaku;Shinohara, Masakazu;Senga, Yoko;Tamori, Yoshikazu;Aoki, Chikako;Matsui, Sho;Sasaki, Tsutomu;Kitamura, Tadahiro;Kuroda, Masashi;Sakaue, Hiroshi;Nomura, Kazuhiro;Yoshino, Kei;Nabatame, Yuko;Itoh, Yoshito;Yamaguchi, Kanji;Hayashi, Yoshitake;Nakae, Jun;Accili, Domenico;Yokomizo, Takehiko;Seino, Susumu;Kasuga, Masato;Ogawa, Wataru, 2020, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117, 21, 11674, 11684

  DOI
• FOXO1 suppresses PGC-1β gene expression in skeletal muscles, Nakai, Shiho;Oyabu, Mamoru;Hatazawa, Yukino;Akashi, Shiori;Kitamura, Tadahiro;Miura, Shinji;Kamei, Yasutomi, 2020, FEBS OPEN BIO, 10, 7, 1373, 1388

  DOI
• Pseudo-hyperglucagonemia was observed in pancreatectomized patients when measured by glucagon sandwich enzyme-linked immunosorbent assay, Kobayashi, Masaki;Waki, Hironori;Nakayama, Hitomi;Miyachi, Atsushi;Mieno, Eri;Hamajima, Hitoshi;Goto, Moritaka;Yamada, Kentaro;Yamauchi, Toshimasa;Kadowaki, Takashi;Kitamura, Tadahiro, 2021, JOURNAL OF DIABETES INVESTIGATION, 12, 2, 286, 289

  DOI
• Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice, Kohno, Daisuke;Furusawa, Kenichi;Kitamura, Tadahiro, 2020, ENDOCRINE JOURNAL, 67, 5, 523, 529

  DOI
• HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1, Sato, Yoshifumi;Rahman, Md Mostafizur;Haneda, Masaki;Tsuyama, Tomonori;Mizumoto, Tomoya;Yoshizawa, Tatsuya;Kitamura, Tadahiro;Gonzalez, Frank J.;Yamamura, Ken-ichi;Yamagata, Kazuya, 2020, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866, 11

  DOI
• Leukotriene A(4)hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis, Uzawa, Hirotsugu;Kohno, Daisuke;Koga, Tomoaki;Sasaki, Tsutomu;Fukunaka, Ayako;Okuno, Toshiaki;Jo-Watanabe, Airi;Kazuno, Saiko;Miyatsuka, Takeshi;Kitamura, Tadahiro;Fujitani, Yoshio;Watada, Hirotaka;Saeki, Kazuko;Yokomizo, Takehiko, 2020, FASEB JOURNAL, 34, 10, 13949, 13958

  DOI
• Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes, Kobayashi, Masaki;Satoh, Hiroaki;Matsuo, Toshihiro;Kusunoki, Yoshiki;Tokushima, Masahiko;Watada, Hirotaka;Namba, Mitsuyoshi;Kitamura, Tadahiro, 2020, ENDOCRINE JOURNAL, 67, 9, 903, 922
• Effects of the Once-Weekly DPP4 Inhibitor Omarigliptin on Glycemic Control in Patients with Type 2 Diabetes Mellitus on Maintenance Hemodialysis: A 24-Week Open-Label, Multicenter Randomized Controlled Study, Yoshizawa, Yuta;Hosojima, Michihiro;Kabasawa, Hideyuki;Tanabe, Naohito;Ugamura, Daisuke;Koda, Yutaka;Shimada, Hisaki;Takasawa, Tetsuya;Ito, Takahito;Kitamura, Tadahiro;Kobayashi, Masaki;Suzuki, Yoshiki;Narita, Ichiei;Saito, Akihiko, 2021, DIABETES THERAPY, 12, 3, 655, 667

  DOI
• Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load, Kuramoto, Naoki;Nomura, Kazuhiro;Kohno, Daisuke;Kitamura, Tadahiro;Karsenty, Gerard;Hosooka, Tetsuya;Ogawa, Wataru, 2021, SCIENTIFIC REPORTS, 11, 1

  DOI
• Measurement of Plasma Glucagon Levels Using Mass Spectrometry in Patients with Type 2 Diabetes on Maintenance Hemodialysis, Yoshizawa, Yuta;Hosojima, Michihiro;Kabasawa, Hideyuki;Tanabe, Naohito;Miyachi, Atsushi;Hamajima, Hitoshi;Mieno, Eri;Kobayashi, Masaki;Kitamura, Tadahiro;Narita, Ichiei;Saito, Akihiko, 2021, KIDNEY & BLOOD PRESSURE RESEARCH, 46, 5, 652, 656

  DOI
• Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling, Morio, Atsushi;Tsutsumi, Rie;Kondo, Takashi;Miyoshi, Hirotsugu;Kato, Takahiro;Narasaki, Soshi;Satomi, Shiho;Nakaya, Erika;Kuroda, Masashi;Sakaue, Hiroshi;Kitamura, Tadahiro;Tsutsumi, Yasuo M., 2021, NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 31, 10, 2979, 2986

  DOI
• Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice, Wada, Eri;Kobayashi, Masaki;Kohno, Daisuke;Kikuchi, Osamu;Suga, Takayoshi;Matsui, Sho;Yokota-Hashimoto, Hiromi;Honzawa, Norikiyo;Ikeuchi, Yuichi;Tsuneoka, Haruka;Hirano, Touko;Obinata, Hideru;Sasaki, Tsutomu;Kitamura, Tadahiro, 2021, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 97

  DOI
• Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model, Morio, Atsushi;Tsutsumi, Rie;Satomi, Shiho;Kondo, Takashi;Miyoshi, Hirotsugu;Kato, Takahiro;Kuroda, Masashi;Kitamura, Tadahiro;Hara, Kenta;Saeki, Noboru;Sakaue, Hiroshi;Tsutsumi, Yasuo M., 2021, DIABETOLOGY & METABOLIC SYNDROME, 13, 1

  DOI
• The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels, Kondo, Yuri;Ozawa, Atsushi;Kohno, Daisuke;Saito, Kazuma;Buyandalai, Battsetseg;Yamada, Sayaka;Horiguchi, Kazuhiko;Nakajima, Yasuyo;Shibusawa, Nobuyuki;Harada, Akihiro;Yokoo, Hideaki;Akiyama, Hideo;Sasaki, Tsutomu;Kitamura, Tadahiro;Yamada, Masanobu, 2022, THYROID, 32, 1, 105, 114

  DOI
• Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients, Yamamoto, Yukako;Ozamoto, Yuki;Kobayashi, Masaki;Tezuka, Yuji;Azuma, Choka;Sekine, Osamu;Ito-Kobayashi, Jun;Washiyama, Miki;Oe, Yasumitsu;Iwanishi, Masanori;Togawa, Takeshi;Hagiwara, Akeo;Kitamura, Tadahiro;Shimatsu, Akira;Kashiwagi, Atsunori, 2022, ENDOCRINE JOURNAL

  DOI
• Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells, Honzawa, Norikiyo;Fujimoto, Kei;Kobayashi, Masaki;Kohno, Daisuke;Kikuchi, Osamu;Yokota-Hashimoto, Hiromi;Wada, Eri;Ikeuchi, Yuichi;Tabei, Yoko;Ii, Gerald W. Dorn;Utsunomiya, Kazunori;Nishimura, Rimei;Kitamura, Tadahiro, 2022, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23, 7

  DOI
• Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients, Yamamoto, Yukako;Ozamoto, Yuki;Kobayashi, Masaki;Tezuka, Yuji;Azuma, Choka;Sekine, Osamu;Ito-Kobayashi, Jun;Washiyama, Miki;Oe, Yasumitsu;Iwanishi, Masanori;Togawa, Takeshi;Hagiwara, Akeo;Kitamura, Tadahiro;Shimatsu, Akira;Kashiwagi, Atsunori, 2022, ENDOCRINE JOURNAL, 69, 6, 689, 703
• A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels, Kobayashi, Masaki;Maruyama, Nobuhiro;Yamamoto, Yukako;Togawa, Takeshi;Ida, Takanori;Yoshida, Morikatsu;Miyazato, Mikiya;Kitada, Masahisa;Hayashi, Yoshitaka;Kashiwagi, Atsunori;Kitamura, Tadahiro, 2023, JOURNAL OF DIABETES INVESTIGATION, 14, 5, 648, 658

  DOI
• Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders, Zhao, Min;Okunishi, Katsuhide;Bu, Yun;Kikuchi, Osamu;Wang, Hao;Kitamura, Tadahiro;Izumi, Tetsuro, 2023, JCI INSIGHT, 8, 4

  DOI
• Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes, Ichikawa, Raishi;Takano, Koji;Fujimoto, Kazumi;Kobayashi, Masaki;Kitamura, Tadahiro;Shichiri, Masayoshi;Miyatsuka, Takeshi, 2023, JOURNAL OF DIABETES INVESTIGATION, 14, 10, 1172, 1174

  DOI
• Role of FoxO proteins in the insulin signaling, KITAMURA Tadahiro, Aug. 2007, 79, 8, 785, 789
• Role of FoxO Proteins in Pancreatic β Cells, KITAMURA TADAHIRO;IDO KITAMURA YUKARI, Aug. 2007, Endocrine Journal, 54, 4, 507, 515

  DOI
• The role of transcription factor FoxO1 in the regulation of appetite-related neuropeptides, KITAMURA Tadahiro, Sep. 2007, 55, 9, 835, 846
• Roles of FoxO1 and Sirt1 in the central regulation of food intake, SASAKI Tsutomu;KITAMURA Tadahiro, Nov. 2010, Endocr J, 57, 11, 939, 946
• 機能性ディスペプシアの病態生理 : 胃排出能と遺伝子多型, ;;;, Jun. 2011, 41, 3, 87, 93
• Hypothalamic Sirtl and regulation of food intake, KITAMURA Tadahiro;SASAKI Tsutomu, Sep. 2012, Diabetology international, 3, 3, 109, 112
• Frontier of Central Nervous System and Obesity Research, ;;;;;;, Dec. 2012, 18, 3, 156, 157
• 転写因子FoxO1の各種インスリン標的臓器における役割（第55回北関東医学会総会抄録 特別講演）, 北村 忠弘, Aug. 2008, The Kitakanto medical journal, 58, 3, 347, 347
• 転写因子Fox01を用いたインスリン産生細胞の作成 : 糖尿病の再生医療を目指して (助成研究報告), 北村 忠弘, Aug. 2008, 24, 80, 85

  DOI
• 群馬大学医学部と生体調節研究所 (大学紹介), ;, Aug. 2008, 24, 118, 119

  DOI
• Roles of FoxO1 and Sirt1 in the central regulation of food intake, Sasaki Tsutomu;Kitamura Tadahiro, 2010, Endocrine Journal, 57, 11, 939, 946

  DOI
• ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription, Lee Yong-Soo;Kobayashi Masaki;Kikuchi Osamu;Sasaki Tsutomu;Yokota-Hashimoto Hiromi;Susanti Vina Yanti;Ido Kitamura Yukari;Kitamura Tadahiro, 2014, Endocrine Journal, 61, 1, 85, 90

  DOI
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Sasaki Tsutomu;Shimpuku Mayumi;Kitazumi Tomoya;Hiraga Haruna;Nakagawa Yuko;Shibata Hiroshi;Okamatsu-Ogura Yuko;Kikuchi Osamu;Kim Hye-jin;Fujita Yuki;Maruyama Jun;Susanti Vina Yanti;Yokota-Hashimoto Hiromi;Kobayashi Masaki;Saito Masayuki;Kitamura Tadahiro, 2013, Endocrine Journal, 60, 10, 1117, 1129

  DOI
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue [Rapid Communication], Sasaki Tsutomu;Hiraga Haruna;Yokota-Hashimoto Hiromi;Kitamura Tadahiro, 2015, Endocrine Journal, 62, 5, 469, 473

  DOI
• Intracerebroventricular injection of adiponectin regulates locomotor activity in rats, Miyatake Yumiko;Shiuchi Tetsuya;Ueta Tomoyo;Taniguchi Yasuko;Futami Akari;Sato Fukiko;Kitamura Tadahiro;Tsutsumi Rie;Harada Nagakatsu;Nakaya Yutaka;Sakaue Hiroshi, 2015, The Journal of Medical Investigation, 62, 3.4, 199, 203

  DOI
• Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice, Sasaki Tsutomu;Kuroko Mitsutaka;Sekine Sawako;Matsui Sho;Kikuchi Osamu;Susanti Vina Yanti;Kobayashi Masaki;Tanaka Yoshinori;Yuasa Tomoyuki;Kitamura Tadahiro, 2015, Endocrine Journal, 62, 9, 787, 796

  DOI
• Pancreatic β Cell Dedifferentiation, Kitamura Tadahiro, 2016, Journal of the Japan Diabetes Society, 59, 5, 336, 339

  DOI
• New Analytical Methods for Glucagon, Kitamura Tadahiro, 2018, Journal of the Japan Diabetes Society, 61, 2, 36, 38

  DOI
• Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes, Ichikawa Raishi;Takano Koji;Fujimoto Kazumi;Motomiya Tetsuya;Kobayashi Masaki;Kitamura Tadahiro;Shichiri Masayoshi, 2019, Endocrine Journal, 66, 8, 663, 675

  DOI
• Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice, Kohno Daisuke;Furusawa Kenichi;Kitamura Tadahiro, 2020, Endocrine Journal, 67, 5, 523, 529

  DOI
• Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes, Kobayashi Masaki;Satoh Hiroaki;Matsuo Toshihiro;Kusunoki Yoshiki;Tokushima Masahiko;Watada Hirotaka;Namba Mitsuyoshi;Kitamura Tadahiro, 2020, Endocrine Journal, 67, 9, 903, 922

  DOI
• Recent Progress of Glucagon Research, Kitamura Tadahiro, Oct. 2019, Nihon Naika Gakkai Zasshi, 108, 10, 2177, 2185

  DOI
• Report of the Japan Diabetes Society's Committee on Validation of Glucagon Assay Methods: Plasma Glucagon Levels Measured by a Novel System Correlate With the Pathology of Diabetes, Kitamura Tadahiro;Watada Hirotaka;Nagasaka Shoichiro;Ishihara Hisamitsu;Shiba Teruo;Ueki Kohjiro;Namba Mitsuyoshi, Dec. 2020, Journal of the Japan Diabetes Society, 63, 12, 826, 834

  DOI
• Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients, Yamamoto Yukako;Ozamoto Yuki;Kobayashi Masaki;Tezuka Yuji;Azuma Choka;Sekine Osamu;Ito-Kobayashi Jun;Washiyama Miki;Oe Yasumitsu;Iwanishi Masanori;Togawa Takeshi;Hagiwara Akeo;Kitamura Tadahiro;Shimatsu Akira;Kashiwagi Atsunori, 2022, Endocrine Journal, 69, 6, 689, 703

  DOI
• Role of FoxO Proteins in Pancreatic beta Cells., Kitamura Tadahiro;Ido Kitamura Yukari, May 2007, Endocrine journal, 54, 4

  DOI
• [Role of FoxO proteins in insulin signaling]., Kitamura Tadahiro, Seikagaku. The Journal of Japanese Biochemical Society, 79, 8
• Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes., Kobayashi Masaki;Ohnishi Hiroshi;Okazawa Hideki;Murata Yoji;Hayashi Yuriko;Kobayashi Hisae;Kitamura Tadahiro;Matozaki Takashi, Jul. 2008, Endocrinology, 149, 11

  DOI
• Dicer is required for maintaining adult pancreas., Morita Sumiyo;Hara Akemi;Kojima Itaru;Horii Takuro;Kimura Mika;Kitamura Tadahiro;Ochiya Takahiro;Nakanishi Katsumi;Matoba Ryo;Matsubara Kenichi;Hatada Izuho, Jan. 2009, PloS one, 4, 1

  DOI
• 【糖尿病治療薬Update-適正使用に向けて】経口血糖降下薬の特性と注意点　DPP-4阻害薬, 北村 忠弘, Jan. 2016, 53, 1, 45
• 【新時代の臨床糖尿病学(上)-より良い血糖管理をめざして-】糖・エネルギー代謝制御因子　膵β細胞・インスリン　膵β細胞の容量減少・機能不全・不活化機序　膵β細胞機能不全と脱分化, 北村 忠弘, Feb. 2016, 74, 増刊1 新時代の臨床糖尿病学(上), 84
• 【新時代の臨床糖尿病学(上)-より良い血糖管理をめざして-】糖尿病の検査・診断の臨床的意義　グルカゴン測定法, 北村 忠弘, Feb. 2016, 74, 増刊1 新時代の臨床糖尿病学(上), 393
• 【糖尿病治療の現在と未来】糖尿病に関する検査の進歩と課題　グルカゴン測定の課題, 北村 忠弘, Mar. 2016, 104, Suppl., 244
• 特異的グルカゴン測定キットの開発　真のグルカゴン値の測定による病態解明, 北村 忠弘, Jul. 2016, 42, 8, 355
• グルカゴン　最新の知見, 北村 忠弘, Jun. 2016, 44, 2, 41
• 【膵β細胞機能不全のメカニズム】膵β細胞の脱分化, 北村 忠弘, Jun. 2016, 59, 5, 336
• 新規高特異性サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, ;;;;;;;;, Apr. 2016, 59, Suppl.1, S
• 新規開発測定系を用いた血糖変化に伴うグルカゴン分泌動態の解析, ;;;;;, Apr. 2016, 59, Suppl.1, S
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, ;;;;, Apr. 2016, 59, Suppl.1, S
• 【進化する糖尿病治療!〜話題の新薬と治療法〜】内服薬　新しい標的、グルカゴン受容体とその拮抗薬の開発, 北村 忠弘, Oct. 2016, 8, 10, 28
• 医療トレンド　糖尿病治療におけるグルカゴンの重要性, 北村 忠弘, Oct. 2016, 100, 9
• 【遺伝子制御の新たな主役　栄養シグナル　糖、脂質、アミノ酸による転写調節・生体恒常性機構と疾患をつなぐニュートリゲノミクス】(第3章)栄養による遺伝子制御と生命現象・臓器機能　その破綻と疾患の観点から　栄養素によるグルカゴン、インスリンの変動と糖尿病との関連, ;, Sep. 2016, 34, 15, 2594
• 中枢神経系のSIRT1による食事嗜好性制御機構の解析, ;;;;, Dec. 2015, 88回・38回, [1P1163]
• グルカゴンに作用する糖尿病薬, 北村 忠弘, Jun. 2017, 6, 1, 17
• 新しいグルカゴン測定法の糖尿病診断への応用の可能性, 北村 忠弘, Sep. 2017, 32, 3, 462
• 食嗜好性を制御する脳内分子機構とその破綻　肥満症の病態解明を目指す新機軸　脳SIRT1による栄養素嗜好性の制御メカニズム, ;;, Sep. 2017, 23, Suppl., 131
• SIRT1はFGF21-NRF2-oxytocinシグナルを介してショ糖嗜好性を制御する, ;;;;;, Sep. 2017, 23, Suppl., 164
• 視床下部室傍核THニューロンの肥満発症における役割, ;;, Sep. 2017, 23, Suppl., 173
• 栄養素によるグルカゴン分泌調節機構と糖尿病での破綻機序の解明, ;;;;;, Jan. 2018, 21, Suppl., S
• 【ラ氏島の生物学】グルカゴン測定系, 北村 忠弘, Feb. 2018, 61, 2, 36
• グルカゴンと代謝　新しい測定系で明らかになったこと, 北村 忠弘, Apr. 2018, 55回, 41
• サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, ;;;;;;;;, Dec. 2017, 93, 3, 772
• 新しいグルカゴン測定法の糖尿病診断への応用の可能性, 北村 忠弘, Dec. 2017, 93, 3, 803
• グルカゴンの新規測定法, 北村 忠弘, Feb. 2018, 46, 2, 140
• 食欲・食嗜好の分子・神経基盤　脳SIRT1による栄養素に基づいた食選択行動の制御メカニズム, ;;;, Dec. 2017, 2017年度, [4AW08
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, ;;;;;;, Apr. 2018, 94, 1, 324
• SIRT1はFGF21-NRF2-oxytocinシグナルを介してショ糖嗜好性を制御する, ;;;;;, Apr. 2018, 94, 1, 343
• 空腹時のグルカゴン分泌変動とその生理的意義, ;;;;;;;;, Apr. 2018, 94, 1, 377
• SIRT1はショ糖摂食選択行動を制御する, ;;;;;, Apr. 2018, 72回, 238
• グルカゴンはどこまで判ったか　新規グルカゴン定量システムを用いて何が明らかになったのか(How far have we learned the role of glucagon?　What has become evident using a new glucagon measurement system), ;, Apr. 2018, 61, Suppl.1, S
• SGLT2阻害薬の臨床的役割とメカニズム　膵α細胞におけるSGLT1のグルカゴン分泌調節から予想されるSGLT2阻害薬の作用の違い(SGLT2 inhibitors: Clinical roles and underlying mechanisms　SGLT1 in pancreatic a cells regulates glucagon secretion, possibly explaining the distinct effects of SGLT2 inhibitors), ;, Apr. 2018, 61, Suppl.1, S
• 空腹時における血中グルカゴンの変化とその生理的意義, ;;;;;;;;, Apr. 2018, 61, Suppl.1, S
• SGLT-2阻害薬によるグルカゴン分泌調節機構, ;;;;;;;;;;, Apr. 2018, 61, Suppl.1, S
• 膵α細胞におけるSirt1の機能解析, ;;;;;;, Apr. 2018, 61, Suppl.1, S
• 糖尿病病態での摂取栄養素に対するグルカゴン分泌応答異常の検証, ;;;;;;;;;, Apr. 2018, 61, Suppl.1, S
• 視床下部のFTOによるm6A修飾を介した体重調節機構, ;;;;, Sep. 2018, 24, Suppl., 155
• 糖尿病病態における栄養素負荷時のグルカゴン分泌応答の検討, ;;;;;;;, Sep. 2018, 24, Suppl., 166
• 視床下部室傍核オキシトシンニューロンのSIRT1がショ糖嗜好性を制御する, ;;;;;, Sep. 2018, 24, Suppl., 185
• グルカゴン研究の重要性と将来展望, 北村 忠弘, Mar. 2019, 85, 3, 402
• SIRT1はFGF21-NRF2-oxytocinシグナルを介してショ糖嗜好性を制御する, ;;;;;, Dec. 2018, 94, 4, 1589
• 分泌顆粒蛋白質フォグリンによるインスリン分泌とシグナルの連結機構, ;;;;;;;;, Sep. 2018, 91回, [3P
• グルカゴンは糖代謝よりもアミノ酸代謝に重要?　糖尿病・肥満に対する治療標的の可能性も含めて, ;;, Mar. 2019, 12, 2, 81
• 絶食時における血中グルカゴンの変化とその生理的意義, ;;;;;, Mar. 2019, 12, 2, 133
• 糖尿病病態での各種栄養素に対するグルカゴン分泌動態の解明, ;;;;;;;, Mar. 2019, 12, 2, 138
• サンドイッチELISAと質量分析を用いた新規グルカゴン測定法, 北村 忠弘, Jun. 2019, 48, 6, 464
• 糖尿病病態におけるアミノ酸のグルカゴン分泌亢進作用, ;;;;;;;, Jan. 2019, 22, Suppl., S
• 消化管グルカゴン関連ペプチドと糖尿病、肥満との関連, 北村 忠弘, Dec. 2018, 32, 1
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構の解明, ;;;;, Apr. 2019, 95, 1, 374
• 視床下部室傍核オキシトシンニューロンのSIRT1が糖質嗜好性を制御する, ;;;;;, Apr. 2019, 95, 1, 399
• 絶食による血中グルカゴンの変化とその生理的意義, ;;;;;;, Apr. 2019, 95, 1, 420
• 膵切除による血中グルカゴンの変化　質量分析装置による解析, ;;;;;;;;;;, Apr. 2019, 62, Suppl.1, S
• グルカゴン測定法の標準化と2型糖尿病の病態把握におけるその臨床的有用性, ;;;;;;;, Apr. 2019, 62, Suppl.1, S
• 糖尿病病態での分岐鎖アミノ酸に対するグルカゴン分泌応答障害の検証, ;;;;;;;, Apr. 2019, 62, Suppl.1, S
• プレプログルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, ;;;, Apr. 2019, 62, Suppl.1, S
• 医学と医療の最前線　グルカゴン研究における最近の進歩, 北村 忠弘, Oct. 2019, 108, 10, 2177
• 栄養と感覚(嗅覚/味覚を中心とした)の新しい融合研究領域　グルカゴンによるアミノ酸・糖代謝調節と糖尿病・肥満, ;;, Apr. 2019, 73回, 156
• 糖尿病病態での分岐鎖アミノ酸によるグルカゴン分泌応答亢進機序の解明, ;;;;;;;, Apr. 2019, 73回, 277
• SIRT1による単純糖質嗜好性の制御を担うのは、視床下部室傍核のOxytocinニューロンである, ;;;;;, Apr. 2019, 73回, 302
• 【SGLT2阻害薬の可能性～これまで、そしてこれから～】SGLT2阻害薬とグルカゴン分泌, 北村 忠弘, Dec. 2019, 11, 6, 6
• 英文論文を書いてEJに出そう!, 北村 忠弘, Oct. 2019, 95, 2, 696
• SGLT2とグルカゴン分泌, 北村 忠弘, Feb. 2020, 50, 2, 127
• 糖尿病病態で分岐鎖アミノ酸摂取がグルカゴン分泌に与える意義の解明, ;;;, Jan. 2020, 23, Suppl., S
• 分泌顆粒蛋白質フォグリンによる膵β細胞増殖の制御, ;;;;, Aug. 2019, 69, 3, 294
• 糖尿病病態での分岐鎖アミノ酸によるグルカゴン過剰分泌作用の解明, ;;;;, Oct. 2019, 25, Suppl., 252
• 視床下部のFTOによる体重調節機構, ;;;;, Oct. 2019, 25, Suppl., 285
• 2型糖尿病におけるグルカゴン分泌異常, ;, Apr. 2020, 57回, 65
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構, ;;;, Aug. 2020, 96, 1, 237
• 絶食に伴う代謝変化に対するグルカゴンの生理的役割, ;;;;;;, Aug. 2020, 96, 1, 237
• 糖尿病高グルカゴン血症における分岐鎖アミノ酸の関与について, ;;;;, Apr. 2020, 74回, 214
• 絶食時におけるグルカゴンの生理的役割, ;;;;;;, Aug. 2020, 13, 2, 93
• 糖尿病病態における分岐鎖アミノ酸負荷時のグルカゴン分泌応答機序の解明, ;;;;, Aug. 2020, 13, 2, 124
• 【インスリン分泌機構とその異常】グルカゴン分泌異常, 北村 忠弘, Nov. 2020, 12, 7, 54
• 【糖尿病治療・研究の最前線2021】基礎研究　2型糖尿病におけるグルカゴン分泌異常, 北村 忠弘, Jan. 2021, 276, 5, 387
• 【グルカゴン(膵α細胞)はどこまでわかったか】正確なグルカゴン測定法の開発と、それを用いた2型糖尿病のグルカゴン評価, ;, Mar. 2021, 13, 3, 38
• 【グルカゴン(膵α細胞)はどこまでわかったか】SGLT2阻害薬とグルカゴン, ;, Mar. 2021, 13, 3, 64
• グルカゴン・インクレチン研究Up to Date　グルカゴン測定系と糖尿病におけるグルカゴン分泌異常, ;, Aug. 2020, 63, Suppl.1, S
• 肥満外科手術による血中グルカゴンの変化　測定系による分泌応答の相違について, ;;;;;;;;;;;, Aug. 2020, 63, Suppl.1, S
• 分岐鎖アミノ酸によるグルカゴン分泌機序と糖尿病病態での破綻機序の解明, ;;;;, Aug. 2020, 63, Suppl.1, S
• グルカゴンシグナルによる膵PP細胞の過形成のメカニズムの解明, ;;;;;, Aug. 2020, 63, Suppl.1, S
• いま知っておきたい最新の臨床検査　身近な疾患を先端技術で診断(Vol.5)　糖尿病の病態診断マーカーとしてのグルカゴン測定, 北村 忠弘, May 2021, 277, 6, 494
• 糖尿病とホルモンの最前線　グルカゴン, 北村 忠弘, Apr. 2021, 97, 1, 177
• 視床下部のFTOによる体重調節機構, ;;;;;, Apr. 2021, 97, 1, 256
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構, ;;;;, Apr. 2021, 97, 1, 275
• 膵α細胞における分岐鎖アミノ酸代謝異常は糖尿病のグルカゴン過剰分泌に関与する, ;;;;;;, Apr. 2021, 97, 1, 319
• 腹腔鏡下スリーブ状胃切除手術による血中グルカゴンの変化　測定系による分泌応答の相違について, ;;;;;;;, Apr. 2021, 97, 1, 320
• 肝臓特異的グルカゴン作用不全によるPP細胞量の制御メカニズムの解明, ;;;;;;;;;;, Apr. 2021, 97, 1, 321
• 膵α細胞からのグルカゴン分泌にPKCδが関与する, ;;;;, Apr. 2021, 97, 1, 321
• グルカゴン測定法検証のための委員会報告　新たな測定法によるグルカゴン値は糖尿病病態の把握に役立つ, ;;;;;;, Dec. 2020, 63, 12, 826
• α細胞(グルカゴン)研究Update, 北村 忠弘, Mar. 2021, 64, 3, 206
• グルカゴンに着目した糖尿病治療戦略　BG製剤とDPP4阻害薬併用と配合剤の意義, 北村 忠弘, Mar. 2021, 64, 3, 216
• メトホルミンと新薬の併用を活用した新しい糖尿病治療　グルカゴンを標的とした新しい糖尿病治療薬の可能性, 北村 忠弘, May 2021, 64, Suppl.1, S21
• 膵α細胞における分岐鎖アミノ酸代謝異常は糖尿病のグルカゴン過剰分泌に関与する, ;;;;;;, May 2021, 64, Suppl.1, YIA
• 高特異性グルカゴンサンドイッチELISAの開発と臨床的有用性の検証, ;;;;;;;;;, May 2021, 64, Suppl.1, I
• 【内分泌代謝領域での新たな治療薬・治療法】グルカゴン受容体阻害薬, 北村 忠弘, Sep. 2021, 53, 3, 261
• 【栄養・代謝物シグナルと食品機能　転写、エピゲノムの制御から代謝性疾患の治療・予防に向けて】(第3章)栄養・代謝物シグナル修飾および破綻と疾患　糖尿病病態における高グルカゴン血症と分岐鎖アミノ酸の関連, ;, May 2022, 40, 7, 1168
• 視床下部-下垂体-甲状腺系の責任中枢は視床下部室傍核であるPVN特異的TRHノックアウトマウスの作製と解析, ;;;;;;;, Mar. 2022, 97, 5, 1246
• グルカゴン測定法の改良と、その臨床応用, ;, Apr. 2022, 98, 1, 206
• 新開発グルカゴンサンドイッチELISAの2型糖尿病の病態把握における臨床的有用性, ;;;, Apr. 2022, 98, 1, 323
• イメグリミンによるグルカゴン分泌への影響の検討, ;, Apr. 2022, 98, 1, 360
• 臨床・基礎におけるグルカゴン研究の進歩　正確なグルカゴン測定法の開発と、2型糖尿病におけるグルカゴン分泌異常, ;, Apr. 2022, 65, Suppl.1, S
• SGLT特異的基質(αMG)のin vivoにおける内因性グルカゴン分泌への影響の検討, ;, Apr. 2022, 65, Suppl.1, S
• 2型糖尿病の病態把握における新開発グルカゴンサンドイッチELISAの有用性の検証, ;;;;, Apr. 2022, 65, Suppl.1, S
• イメグリミンによるグルカゴン分泌への影響の検討, ;, Apr. 2022, 65, Suppl.1, S
• 膵α細胞グルコーストランスポーターによるグルカゴン分泌の制御, ;;;, Apr. 2022, 65, Suppl.1, S
• 肥満を取り巻くinterkingdom-interaction(内分泌・神経・免疫など)　エネルギー代謝調節機構におけるThyrotropin-Releasing Hormone(TRH)の役割, ;;;;;, Mar. 2022, 27, Suppl., 220
• AgRPニューロンのFTOによる体重調節機構, ;;;;;;, Mar. 2022, 27, Suppl., 344
• グルカゴンと糖尿病の新知見について　正確なグルカゴン測定法により,2型糖尿病におけるグルカゴン分泌異常が明らかとなった, ;, Oct. 2022, 5138, 57
• グルカゴン発見100周年, 北村 忠弘, Feb. 2023, 63, 2, 28
• 膵α細胞SGLT1によるグルカゴン分泌の制御と糖尿病の関連, ;;;;, May 2023, 99, 1, 304
• 2型糖尿病患者の病態把握における新開発グルカゴンサンドイッチELISAの臨床的有用性の検証, ;;;;;;;;, May 2023, 99, 1, 327
• イメグリミンによるグルカゴン分泌への影響, ;, May 2023, 99, 1, 372
• グルカゴン研究の歩みとこれからの展開　新規グルカゴンサンドイッチELISAの開発と有用性, ;, Apr. 2023, 66, Suppl.1, S
• 2型糖尿病の病態把握におけるグルカゴン測定の有用性　高精度サンドイッチELISAによる検証, ;;;;;;;;, Apr. 2023, 66, Suppl.1, S
• イメグリミンによるグルカゴン分泌への影響, ;, Apr. 2023, 66, Suppl.1, S
• Methyl α-D-Glucopyranosideによる糖・脂質代謝改善メカニズムの解明, ;;;;;;;;, Apr. 2023, 66, Suppl.1, S
• 膵α細胞SGLT1によるグルカゴン分泌の制御と糖尿病の関連, ;;;;;, Apr. 2023, 66, Suppl.1, S
• グルカゴン研究update　最も正確なサンドイッチELISA法の確立, ;, Jun. 2023, 56, 6, 732
• 視床下部室傍核ドーパミンニューロンの摂食行動における役割, ;;;;;, Nov. 2022, 28, Suppl., 287
• グルカゴン研究Update　グルカゴンを標的とした新しい診断法と治療法の可能性, 北村 忠弘, May 2023, 17, 1, 26
• 膵α細胞のグルコーストランスポーターはグルカゴン分泌を制御する, ;;;;;;;, May 2023, 17, 1, 64
• Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide., Sasaki Tsutomu;Kim Hye-Jin;Kobayashi Masaki;Kitamura Yukari-Ido;Yokota-Hashimoto Hiromi;Shiuchi Tetsuya;Minokoshi Yasuhiko;Kitamura Tadahiro, Apr. 2010, Endocrinology, 151, 6

  DOI
• Roles of FoxO1 and Sirt1 in the central regulation of food intake., Sasaki Tsutomu;Kitamura Tadahiro, Oct. 2010, Endocrine journal, 57, 11

  DOI
• Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta., Tanioka Toshihiro;Tamura Yoshiaki;Fukaya Makiko;Shinozaki Shohei;Mao Ji;Kim Minhye;Shimizu Nobuyuki;Kitamura Tadahiro;Kaneki Masao, Jun. 2011, The Journal of biological chemistry, 286, 33

  DOI
• [The roles of PPAR, C/EBP and FoxO families in adipocyte differentiation and proliferation]., Kitamura Tadahiro;Kitamura Yukari, Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 1
• Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance., Kim Hye-Jin;Kobayashi Masaki;Sasaki Tsutomu;Kikuchi Osamu;Amano Kosuke;Kitazumi Tomoya;Lee Yong-Soo;Yokota-Hashimoto Hiromi;Susanti Vina Yanti;Kitamura Yukari Ido;Nakae Jun;Kitamura Tadahiro, Dec. 2011, Endocrinology, 153, 2

  DOI
• FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice., Kobayashi Masaki;Kikuchi Osamu;Sasaki Tsutomu;Kim Hye-Jin;Yokota-Hashimoto Hiromi;Lee Yong-Soo;Amano Kosuke;Kitazumi Tomoya;Susanti Vina Yanti;Kitamura Yukari Ido;Kitamura Tadahiro, Jan. 2012, American journal of physiology. Endocrinology and metabolism, 302, 5

  DOI
• FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization., Kikuchi Osamu;Kobayashi Masaki;Amano Kosuke;Sasaki Tsutomu;Kitazumi Tomoya;Kim Hye-Jin;Lee Yong-Soo;Yokota-Hashimoto Hiromi;Kitamura Yukari-Ido;Kitamura Tadahiro, Feb. 2012, PloS one, 7, 2

  DOI
• Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion., Nakakura Takashi;Mogi Chihiro;Tobo Masayuki;Tomura Hideaki;Sato Koichi;Kobayashi Masaki;Ohnishi Hiroshi;Tanaka Shigeyasu;Wayama Mitsutoshi;Sugiyama Tetsuya;Kitamura Tadahiro;Harada Akihiro;Okajima Fumikazu, Jun. 2012, Endocrinology, 153, 9

  DOI
• Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation., Ido-Kitamura Yukari;Sasaki Tsutomu;Kobayashi Masaki;Kim Hye-Jin;Lee Yong-Soo;Kikuchi Osamu;Yokota-Hashimoto Hiromi;Iizuka Katsumi;Accili Domenico;Kitamura Tadahiro, Oct. 2012, PloS one, 7, 10

  DOI
• A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells., Masubuchi Yosuke;Nakagawa Yuko;Ma Jinhui;Sasaki Tsutomu;Kitamura Tadahiro;Yamamoto Yoritsuna;Kurose Hitoshi;Kojima Itaru;Shibata Hiroshi, Jan. 2013, PloS one, 8, 1

  DOI
• [Obesity and the central regulation of energy metabolism]., Kitamura Tadahiro, Nihon rinsho. Japanese journal of clinical medicine, 71, 2
• The role of FOXO1 in β-cell failure and type 2 diabetes mellitus., Kitamura Tadahiro, Aug. 2013, Nature reviews. Endocrinology, 9, 10

  DOI
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates., Sasaki Tsutomu;Shimpuku Mayumi;Kitazumi Tomoya;Hiraga Haruna;Nakagawa Yuko;Shibata Hiroshi;Okamatsu-Ogura Yuko;Kikuchi Osamu;Kim Hye-jin;Fujita Yuki;Maruyama Jun;Susanti Vina Yanti;Yokota-Hashimoto Hiromi;Kobayashi Masaki;Saito Masayuki;Kitamura Tadahiro, Aug. 2013, Endocrine journal, 60, 10

  DOI
• ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription., Lee Yong-Soo;Kobayashi Masaki;Kikuchi Osamu;Sasaki Tsutomu;Yokota-Hashimoto Hiromi;Susanti Vina Yanti;Ido Kitamura Yukari;Kitamura Tadahiro, Oct. 2013, Endocrine journal, 61, 1

  DOI
• A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting., Syamsunarno Mas Rizky A A;Iso Tatsuya;Hanaoka Hirofumi;Yamaguchi Aiko;Obokata Masaru;Koitabashi Norimichi;Goto Kosaku;Hishiki Takako;Nagahata Yoshiko;Matsui Hiroki;Sano Motoaki;Kobayashi Masaki;Kikuchi Osamu;Sasaki Tsutomu;Maeda Kazuhisa;Murakami Masami;Kitamura Tadahiro;Suematsu Makoto;Tsushima Yoshito;Endo Keigo;Hotamisligil Gökhan S;Kurabayashi Masahiko, Nov. 2013, PloS one, 8, 11

  DOI
• Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice., Sasaki Tsutomu;Kikuchi Osamu;Shimpuku Mayumi;Susanti Vina Yanti;Yokota-Hashimoto Hiromi;Taguchi Ryo;Shibusawa Nobuyuki;Sato Takashi;Tang Lijun;Amano Kosuke;Kitazumi Tomoya;Kuroko Mitsutaka;Fujita Yuki;Maruyama Jun;Lee Yong-Soo;Kobayashi Masaki;Nakagawa Takashi;Minokoshi Yasuhiko;Harada Akihiro;Yamada Masanobu;Kitamura Tadahiro, Dec. 2013, Diabetologia, 57, 4

  DOI
• Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice., Usui Taro;Kajita Kazuo;Kajita Toshiko;Mori Ichiro;Hanamoto Takayuki;Ikeda Takahide;Okada Hideyuki;Taguchi Koichiro;Kitada Yoshihiko;Morita Hiroyuki;Sasaki Tsutomu;Kitamura Tadahiro;Sato Takashi;Kojima Itaru;Ishizuka Tatsuo, Apr. 2014, FEBS letters, 588, 10

  DOI
• Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor., Yoshino Satoshi;Satoh Tetsurou;Yamada Masanobu;Hashimoto Koshi;Tomaru Takuya;Katano-Toki Akiko;Kakizaki Satoru;Okada Shuichi;Shimizu Hiroyuki;Ozawa Atsushi;Tuchiya Takafumi;Ikota Hayato;Nakazato Yoichi;Mori Munemasa;Matozaki Takashi;Sasaki Tsutomu;Kitamura Tadahiro;Mori Masatomo, Jul. 2014, Endocrinology, 155, 9

  DOI
• Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice., Susanti Vina Yanti;Sasaki Tsutomu;Yokota-Hashimoto Hiromi;Matsui Sho;Lee Yong-Soo;Kikuchi Osamu;Shimpuku Mayumi;Kim Hye-Jin;Kobayashi Masaki;Kitamura Tadahiro, Jul. 2014, Obesity (Silver Spring, Md.), 22, 10

  DOI
• FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification., Kamei Yasutomi;Hattori Maki;Hatazawa Yukino;Kasahara Tomomi;Kanou Masanobu;Kanai Sayaka;Yuan Xunmei;Suganami Takayoshi;Lamers Wouter H;Kitamura Tadahiro;Ogawa Yoshihiro, Jul. 2014, American journal of physiology. Endocrinology and metabolism, 307, 6

  DOI
• Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis., Kohno Daisuke;Lee Syann;Harper Matthew J;Kim Ki Woo;Sone Hideyuki;Sasaki Tsutomu;Kitamura Tadahiro;Fan Guoping;Elmquist Joel K, The Journal of neuroscience : the official journal of the Society for Neuroscience, 34, 46

  DOI
• A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism., Cook Joshua R;Matsumoto Michihiro;Banks Alexander S;Kitamura Tadahiro;Tsuchiya Kyoichiro;Accili Domenico, Jan. 2015, Diabetes, 64, 6

  DOI
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue., Sasaki Tsutomu;Hiraga Haruna;Yokota-Hashimoto Hiromi;Kitamura Tadahiro, Apr. 2015, Endocrine journal, 62, 5

  DOI
• Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice., Sasaki Tsutomu;Kuroko Mitsutaka;Sekine Sawako;Matsui Sho;Kikuchi Osamu;Susanti Vina Yanti;Kobayashi Masaki;Tanaka Yoshinori;Yuasa Tomoyuki;Kitamura Tadahiro, Jun. 2015, Endocrine journal, 62, 9

  DOI
• N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food., Sasaki Tsutomu;Kinoshita Yoshihiro;Matsui Sho;Kakuta Shigeru;Yokota-Hashimoto Hiromi;Kinoshita Kuni;Iwasaki Yusaku;Kinoshita Toshio;Yada Toshihiko;Amano Naoji;Kitamura Tadahiro, Jul. 2015, American journal of physiology. Regulatory, integrative and comparative physiology, 309, 5

  DOI
• Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2)., Ghanem Simona S;Heinrich Garrett;Lester Sumona G;Pfeiffer Verena;Bhattacharya Sumit;Patel Payal R;DeAngelis Anthony M;Dai Tong;Ramakrishnan Sadeesh K;Smiley Zachary N;Jung Dae Y;Lee Yongjin;Kitamura Tadahiro;Ergun Suleyman;Kulkarni Rohit N;Kim Jason K;Giovannucci David R;Najjar Sonia M, Nov. 2015, The Journal of biological chemistry, 291, 2

  DOI
• Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine., Sasaki Tsutomu;Matsui Sho;Kitamura Tadahiro, Jul. 2016, International journal of molecular sciences, 17, 7

  DOI
• DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes., Kuroda Masashi;Tominaga Ayako;Nakagawa Kasumi;Nishiguchi Misa;Sebe Mayu;Miyatake Yumiko;Kitamura Tadahiro;Tsutsumi Rie;Harada Nagakatsu;Nakaya Yutaka;Sakaue Hiroshi, Aug. 2016, PloS one, 11, 8

  DOI
• Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells., Kunii Masataka;Ohara-Imaizumi Mica;Takahashi Noriko;Kobayashi Masaki;Kawakami Ryosuke;Kondoh Yasumitsu;Shimizu Takeshi;Simizu Siro;Lin Bangzhong;Nunomura Kazuto;Aoyagi Kyota;Ohno Mitsuyo;Ohmuraya Masaki;Sato Takashi;Yoshimura Shin-Ichiro;Sato Ken;Harada Reiko;Kim Yoon-Jeong;Osada Hiroyuki;Nemoto Tomomi;Kasai Haruo;Kitamura Tadahiro;Nagamatsu Shinya;Harada Akihiro, Oct. 2016, The Journal of cell biology, 215, 1

  DOI
• Intracerebroventricular injection of ghrelin decreases wheel running activity in rats., Miyatake Yumiko;Shiuchi Tetsuya;Mawatari Kazuaki;Toda Satomi;Taniguchi Yasuko;Futami Akari;Sato Fukiko;Kuroda Masashi;Sebe Mayu;Tsutsumi Rie;Harada Nagakatsu;Minokoshi Yasuhiko;Kitamura Tadahiro;Gotoh Koro;Ueno Masaki;Nakaya Yutaka;Sakaue Hiroshi, Nov. 2016, Peptides, 87

  DOI
• Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness., Kohno Daisuke;Koike Miho;Ninomiya Yuzo;Kojima Itaru;Kitamura Tadahiro;Yada Toshihiko, Nov. 2016, Frontiers in neuroscience, 10

  DOI
• Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: comparison with commercially available immunoassays., Miyachi Atsushi;Kobayashi Masaki;Mieno Eri;Goto Moritaka;Furusawa Kenichi;Inagaki Takashi;Kitamura Tadahiro, Aug. 2017, Analytical and bioanalytical chemistry, 409, 25

  DOI
• Intraperitoneal injection of d-serine inhibits high-fat diet intake and preference in male mice., Sasaki Tsutomu;Yasoshima Yasunobu;Matsui Sho;Yokota-Hashimoto Hiromi;Kobayashi Masaki;Kitamura Tadahiro, Aug. 2017, Appetite, 118

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test., Enomoto Rina;Kurosawa Aya;Nikaido Yoshiaki;Mashiko Misaki;Saheki Toshihiko;Nakajima Nozomi;Kuroiwa Satoshi;Otobe Michinari;Ohsaki Maki;Tooyama Kazuya;Inoue Yusuke;Kuwabara Nobuo;Kikuchi Osamu;Kitamura Tadahiro;Kojima Itaru;Nakagawa Yuko;Saito Tamio;Osada Hiroyuki;Futahashi Mizuko;Sezutsu Hideki;Takeda Shigeki, Aug. 2017, European journal of pharmacology, 814

  DOI
• Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression., Fukunaka Ayako;Fukada Toshiyuki;Bhin Jinhyuk;Suzuki Luka;Tsuzuki Takamasa;Takamine Yuri;Bin Bum-Ho;Yoshihara Toshinori;Ichinoseki-Sekine Noriko;Naito Hisashi;Miyatsuka Takeshi;Takamiya Shinzaburo;Sasaki Tsutomu;Inagaki Takeshi;Kitamura Tadahiro;Kajimura Shingo;Watada Hirotaka;Fujitani Yoshio, Aug. 2017, PLoS genetics, 13, 8

  DOI
• The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells., Torii Seiji;Kubota Chisato;Saito Naoya;Kawano Ayumi;Hou Ni;Kobayashi Masaki;Torii Ryoko;Hosaka Masahiro;Kitamura Tadahiro;Takeuchi Toshiyuki;Gomi Hiroshi, Feb. 2018, The Journal of biological chemistry, 293, 16

  DOI
• ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption., Kato Takehiro;Iizuka Katsumi;Takao Ken;Horikawa Yukio;Kitamura Tadahiro;Takeda Jun, Mar. 2018, Nutrients, 10, 3

  DOI
• A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice., Sasaki Tsutomu;Numano Rika;Yokota-Hashimoto Hiromi;Matsui Sho;Kimura Naobumi;Takeuchi Hideyuki;Kitamura Tadahiro, May 2018, Molecular brain, 11, 1

  DOI
• Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance., Gulshan Maryam;Yaku Keisuke;Okabe Keisuke;Mahmood Arshad;Sasaki Tsutomu;Yamamoto Masashi;Hikosaka Keisuke;Usui Isao;Kitamura Tadahiro;Tobe Kazuyuki;Nakagawa Takashi, Jun. 2018, Aging cell, 17, 4

  DOI
• Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice., Matsui Sho;Sasaki Tsutomu;Kohno Daisuke;Yaku Keisuke;Inutsuka Ayumu;Yokota-Hashimoto Hiromi;Kikuchi Osamu;Suga Takayoshi;Kobayashi Masaki;Yamanaka Akihiro;Harada Akihiro;Nakagawa Takashi;Onaka Tatsushi;Kitamura Tadahiro, Nov. 2018, Nature communications, 9, 1

  DOI
• SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels., Suga Takayoshi;Kikuchi Osamu;Kobayashi Masaki;Matsui Sho;Yokota-Hashimoto Hiromi;Wada Eri;Kohno Daisuke;Sasaki Tsutomu;Takeuchi Kazusane;Kakizaki Satoru;Yamada Masanobu;Kitamura Tadahiro, Oct. 2018, Molecular metabolism, 19

  DOI
• Basal glucagon hypersecretion and response to oral glucose load in prediabetes and mild type 2 diabetes., Ichikawa Raishi;Takano Koji;Fujimoto Kazumi;Motomiya Tetsuya;Kobayashi Masaki;Kitamura Tadahiro;Shichiri Masayoshi, May 2019, Endocrine journal, 66, 8

  DOI
• Cell Autonomous Dysfunction and Insulin Resistance in Pancreatic α Cells., Honzawa Norikiyo;Fujimoto Kei;Kitamura Tadahiro, Jul. 2019, International journal of molecular sciences, 20, 15

  DOI
• Hepatic Gluconeogenic Response to Single and Long-Term SGLT2 Inhibition in Lean/Obese Male Hepatic G6pc-Reporter Mice., Inaba Yuka;Hashiuchi Emi;Watanabe Hitoshi;Kimura Kumi;Sato Makoto;Kobayashi Masaki;Matsumoto Michihiro;Kitamura Tadahiro;Kasuga Masato;Inoue Hiroshi, Endocrinology, 160, 12

  DOI
• FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression., Kodani Noriko;Nakae Jun;Kobayashi Masaki;Kikuchi Osamu;Kitamura Tadahiro;Itoh Hiroshi, Dec. 2019, iScience, 23, 1

  DOI
• Anagliptin suppresses diet-induced obesity through enhancing leptin sensitivity and ameliorating hyperphagia in high-fat high-sucrose diet fed mice., Kohno Daisuke;Furusawa Kenichi;Kitamura Tadahiro, Feb. 2020, Endocrine journal, 67, 5

  DOI
• DNA methylation status influences insulin-induced glucose transport in 3T3-L1 adipocytes by mediating p53 expression., Kuroda Masashi;Onoyama Rumi;Sasaki Waka;Sebe Mayu;Kitamura Tadahiro;Masumoto Saeko;Tsutsumi Rie;Harada Nagakatsu;Sakaue Hiroshi, Feb. 2020, Biochemical and biophysical research communications

  DOI
• The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis., Hosooka Tetsuya;Hosokawa Yusei;Matsugi Kaku;Shinohara Masakazu;Senga Yoko;Tamori Yoshikazu;Aoki Chikako;Matsui Sho;Sasaki Tsutomu;Kitamura Tadahiro;Kuroda Masashi;Sakaue Hiroshi;Nomura Kazuhiro;Yoshino Kei;Nabatame Yuko;Itoh Yoshito;Yamaguchi Kanji;Hayashi Yoshitake;Nakae Jun;Accili Domenico;Yokomizo Takehiko;Seino Susumu;Kasuga Masato;Ogawa Wataru, May 2020, Proceedings of the National Academy of Sciences of the United States of America, 117, 21

  DOI
• FOXO1 suppresses PGC-1β gene expression in skeletal muscles., Nakai Shiho;Oyabu Mamoru;Hatazawa Yukino;Akashi Shiori;Kitamura Tadahiro;Miura Shinji;Kamei Yasutomi, FEBS open bio, 10, 7

  DOI
• Plasma glucagon levels measured by sandwich ELISA are correlated with impaired glucose tolerance in type 2 diabetes., Kobayashi Masaki;Satoh Hiroaki;Matsuo Toshihiro;Kusunoki Yoshiki;Tokushima Masahiko;Watada Hirotaka;Namba Mitsuyoshi;Kitamura Tadahiro, May 2020, Endocrine journal, 67, 9

  DOI
• Pseudo-hyperglucagonemia was observed in pancreatectomized patients when measured by glucagon sandwich enzyme-linked immunosorbent assay., Kobayashi Masaki;Waki Hironori;Nakayama Hitomi;Miyachi Atsushi;Mieno Eri;Hamajima Hitoshi;Goto Moritaka;Yamada Kentaro;Yamauchi Toshimasa;Kadowaki Takashi;Kitamura Tadahiro, Jul. 2020, Journal of diabetes investigation, 12, 2

  DOI
• HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT1., Sato Yoshifumi;Rahman Md Mostafizur;Haneda Masaki;Tsuyama Tomonori;Mizumoto Tomoya;Yoshizawa Tatsuya;Kitamura Tadahiro;Gonzalez Frank J;Yamamura Ken-Ichi;Yamagata Kazuya, Jul. 2020, Biochimica et biophysica acta. Molecular basis of disease, 1866, 11

  DOI
• Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling., Suga Takayoshi;Sato Ken;Ohyama Tatsuya;Matsui Sho;Kobayashi Takeshi;Tojima Hiroki;Horiguchi Norio;Yamazaki Yuichi;Kakizaki Satoru;Nishikido Ayaka;Okamura Takashi;Yamada Masanobu;Kitamura Tadahiro;Uraoka Toshio, World journal of hepatology, 12, 7

  DOI
• Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis., Uzawa Hirotsugu;Kohno Daisuke;Koga Tomoaki;Sasaki Tsutomu;Fukunaka Ayako;Okuno Toshiaki;Jo-Watanabe Airi;Kazuno Saiko;Miyatsuka Takeshi;Kitamura Tadahiro;Fujitani Yoshio;Watada Hirotaka;Saeki Kazuko;Yokomizo Takehiko, Aug. 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34, 10

  DOI
• Effects of the Once-Weekly DPP4 Inhibitor Omarigliptin on Glycemic Control in Patients with Type 2 Diabetes Mellitus on Maintenance Hemodialysis: A 24-Week Open-Label, Multicenter Randomized Controlled Study., Yoshizawa Yuta;Hosojima Michihiro;Kabasawa Hideyuki;Tanabe Naohito;Ugamura Daisuke;Koda Yutaka;Shimada Hisaki;Takasawa Tetsuya;Ito Takahito;Kitamura Tadahiro;Kobayashi Masaki;Suzuki Yoshiki;Narita Ichiei;Saito Akihiko, Jan. 2021, Diabetes therapy : research, treatment and education of diabetes and related disorders, 12, 3

  DOI
• Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load., Kuramoto Naoki;Nomura Kazuhiro;Kohno Daisuke;Kitamura Tadahiro;Karsenty Gerard;Hosooka Tetsuya;Ogawa Wataru, Feb. 2021, Scientific reports, 11, 1

  DOI
• Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice., Wada Eri;Kobayashi Masaki;Kohno Daisuke;Kikuchi Osamu;Suga Takayoshi;Matsui Sho;Yokota-Hashimoto Hiromi;Honzawa Norikiyo;Ikeuchi Yuichi;Tsuneoka Haruka;Hirano Touko;Obinata Hideru;Sasaki Tsutomu;Kitamura Tadahiro, Jun. 2021, The Journal of nutritional biochemistry, 97

  DOI
• Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling., Morio Atsushi;Tsutsumi Rie;Kondo Takashi;Miyoshi Hirotsugu;Kato Takahiro;Narasaki Soshi;Satomi Shiho;Nakaya Erika;Kuroda Masashi;Sakaue Hiroshi;Kitamura Tadahiro;Tsutsumi Yasuo M, Jul. 2021, Nutrition, metabolism, and cardiovascular diseases : NMCD, 31, 10

  DOI
• Measurement of Plasma Glucagon Levels Using Mass Spectrometry in Patients with Type 2 Diabetes on Maintenance Hemodialysis., Yoshizawa Yuta;Hosojima Michihiro;Kabasawa Hideyuki;Tanabe Naohito;Miyachi Atsushi;Hamajima Hitoshi;Mieno Eri;Kobayashi Masaki;Kitamura Tadahiro;Narita Ichiei;Saito Akihiko, Aug. 2021, Kidney & blood pressure research, 46, 5

  DOI
• Comprehensive efficacy of ipragliflozin on various conditioned type 2 diabetes compared with dipeptidyl peptidase-4 inhibitors and with both agents, based on a real-world multicenter trial., Sawano Fumio;Kamei Nozomu;Miyahara Mitsue;Kobuke Kyoko;Nakanishi Shuhei;Nagano Chihiro;Nojima Hideki;Maeda Shusaku;Watanabe Hiroshi;Kishimoto Rui;Yamashita Mami;Hamaoka Aya;Mukai Kana;Tsuboi Tomoko;Mochizuki Hisayoshi;Nakashima Reiko;Sakashita Yu;Morishita Hisaaki;Kitamura Tadahiro, Feb. 2021, Diabetology international, 12, 4

  DOI
• The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic-Pituitary-Thyroid Axis for Regulating Thyroid Hormone Levels., Kondo Yuri;Ozawa Atsushi;Kohno Daisuke;Saito Kazuma;Buyandalai Battsetseg;Yamada Sayaka;Horiguchi Kazuhiko;Nakajima Yasuyo;Shibusawa Nobuyuki;Harada Akihiro;Yokoo Hideaki;Akiyama Hideo;Sasaki Tsutomu;Kitamura Tadahiro;Yamada Masanobu, Dec. 2021, Thyroid : official journal of the American Thyroid Association, 32, 1

  DOI
• Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model., Morio Atsushi;Tsutsumi Rie;Satomi Shiho;Kondo Takashi;Miyoshi Hirotsugu;Kato Takahiro;Kuroda Masashi;Kitamura Tadahiro;Hara Kenta;Saeki Noboru;Sakaue Hiroshi;Tsutsumi Yasuo M, Nov. 2021, Diabetology & metabolic syndrome, 13, 1

  DOI
• Effects of a new 75 g glucose- and high fat-containing cookie meal test on postprandial glucose and triglyceride excursions in morbidly obese patients., Yamamoto Yukako;Ozamoto Yuki;Kobayashi Masaki;Tezuka Yuji;Azuma Choka;Sekine Osamu;Ito-Kobayashi Jun;Washiyama Miki;Oe Yasumitsu;Iwanishi Masanori;Togawa Takeshi;Hagiwara Akeo;Kitamura Tadahiro;Shimatsu Akira;Kashiwagi Atsunori, Jan. 2022, Endocrine journal, 69, 6

  DOI
• Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells., Honzawa Norikiyo;Fujimoto Kei;Kobayashi Masaki;Kohno Daisuke;Kikuchi Osamu;Yokota-Hashimoto Hiromi;Wada Eri;Ikeuchi Yuichi;Tabei Yoko;Dorn Gerald W;Utsunomiya Kazunori;Nishimura Rimei;Kitamura Tadahiro, Apr. 2022, International journal of molecular sciences, 23, 7

  DOI
• Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders., Zhao Min;Okunishi Katsuhide;Bu Yun;Kikuchi Osamu;Wang Hao;Kitamura Tadahiro;Izumi Tetsuro, Feb. 2023, JCI insight, 8, 4

  DOI
• A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels., Kobayashi Masaki;Maruyama Nobuhiro;Yamamoto Yukako;Togawa Takeshi;Ida Takanori;Yoshida Morikatsu;Miyazato Mikiya;Kitada Masahisa;Hayashi Yoshitaka;Kashiwagi Atsunori;Kitamura Tadahiro, Feb. 2023, Journal of diabetes investigation, 14, 5

  DOI
• Robust increase in glucagon secretion after oral protein intake, but not after glucose or lipid intake in Japanese people without diabetes., Ichikawa Raishi;Takano Koji;Fujimoto Kazumi;Kobayashi Masaki;Kitamura Tadahiro;Shichiri Masayoshi;Miyatsuka Takeshi, Jul. 2023, Journal of diabetes investigation, 14, 10

  DOI
• Total Pancreatectomy in a Patient Treated with a Sensor-augmented Pump Showing no Evidence of Hyperglycemia or Ketoacidosis Without any Insulin Administration: A Case Report., Ito Hiroki;Yamada Eijiro;Kobayashi Masaki;Horiguchi Kazuhiko;Okada Shuichi;Kitamura Tadahiro;Yamada Masanobu, Sep. 2023, Internal medicine (Tokyo, Japan)

  DOI
• The oral disposition index calculated from a meal tolerance test is a crucial indicator for evaluating differential normalization of postprandial glucose and triglyceride excursions in morbidly obese patients after laparoscopic sleeve gastrectomy., Yamamoto Yukako;Togawa Takeshi;Sekine Osamu;Ozamoto Yuki;Fuse Junko;Azuma Choka;Ito-Kobayashi Jun;Oe Yasumitsu;Hagiwara Akeo;Kobayashi Masaki;Kitamura Tadahiro;Iwanishi Masanori;Shimatsu Akira;Kashiwagi Atsunori, Oct. 2023, Endocrine journal, 70, 12

  DOI
• Glucagon secretion and its association with glycaemic control and ketogenesis during sodium-glucose cotransporter 2 inhibition by ipragliflozin in people with type 1 diabetes: Results from the multicentre, open-label, prospective study., Nakamura Yuta;Horie Ichiro;Kitamura Tadahiro;Kusunoki Yoshiki;Nishida Kenro;Yamamoto Akane;Hirota Yushi;Fukui Tomoyasu;Maeda Yasutaka;Minami Masae;Matsui Takanori;Kawakami Atsushi;Abiru Norio, Jan. 2024, Diabetes, obesity & metabolism

  DOI
• Glucagon: Physiological and Pharmacological Functions and Pathophysiological Significance in Type 2 Diabetes., Kitamura Tadahiro, Feb. 2024, Endocrinology and metabolism (Seoul, Korea), 39, 1

  DOI
• Useful biomarkers and clinical characteristics of post-pancreatitis diabetes mellitus (PPDM)., Kitamura Tadahiro, Mar. 2024, The Journal of clinical endocrinology and metabolism

  DOI
• 糖尿病治療のパラダイムシフト 膵β細胞量の調節機構, 北村 忠弘, Jan. 2014, 113, 1, 113, 118

  DOI
• The roles of FOXO1 in various metabolic organs, Kitamura Tadahiro;Kitamura Yukari, Apr. 2015, 87, 2, 176, 182

  DOI
• 視床下部-下垂体-甲状腺系の責任中枢は視床下部室傍核であるPVN特異的TRHノックアウトマウスの作製と解析, ;;;;;;;, Mar. 2022, 97, 5, 1246
• 【栄養・代謝物シグナルと食品機能　転写、エピゲノムの制御から代謝性疾患の治療・予防に向けて】(第3章)栄養・代謝物シグナル修飾および破綻と疾患　糖尿病病態における高グルカゴン血症と分岐鎖アミノ酸の関連, ;, May 2022, 40, 7, 1168
• グルカゴン測定法の改良と、その臨床応用, ;, Apr. 2022, 98, 1, 206
• 新開発グルカゴンサンドイッチELISAの2型糖尿病の病態把握における臨床的有用性, ;;;, Apr. 2022, 98, 1, 323
• イメグリミンによるグルカゴン分泌への影響の検討, ;, Apr. 2022, 98, 1, 360
• 臨床・基礎におけるグルカゴン研究の進歩　正確なグルカゴン測定法の開発と、2型糖尿病におけるグルカゴン分泌異常, ;, Apr. 2022, 65, Suppl.1, S
• SGLT特異的基質(αMG)のin vivoにおける内因性グルカゴン分泌への影響の検討, ;, Apr. 2022, 65, Suppl.1, S
• 2型糖尿病の病態把握における新開発グルカゴンサンドイッチELISAの有用性の検証, ;;;;, Apr. 2022, 65, Suppl.1, S
• イメグリミンによるグルカゴン分泌への影響の検討, ;, Apr. 2022, 65, Suppl.1, S
• 膵α細胞グルコーストランスポーターによるグルカゴン分泌の制御, ;;;, Apr. 2022, 65, Suppl.1, S
• グルカゴン研究の歩みとこれからの展開　新規グルカゴンサンドイッチELISAの開発と有用性, ;, Apr. 2023, 66, Suppl.1, S
• 2型糖尿病の病態把握におけるグルカゴン測定の有用性　高精度サンドイッチELISAによる検証, ;;;;;;;;, Apr. 2023, 66, Suppl.1, S
• イメグリミンによるグルカゴン分泌への影響, ;, Apr. 2023, 66, Suppl.1, S
• Methyl α-D-Glucopyranosideによる糖・脂質代謝改善メカニズムの解明, ;;;;;;;;, Apr. 2023, 66, Suppl.1, S
• 膵α細胞SGLT1によるグルカゴン分泌の制御と糖尿病の関連, ;;;;;, Apr. 2023, 66, Suppl.1, S
• グルカゴン研究Update　グルカゴンを標的とした新しい診断法と治療法の可能性, 北村 忠弘, May 2023, 17, 1, 26
• 膵α細胞のグルコーストランスポーターはグルカゴン分泌を制御する, ;;;;;;;, May 2023, 17, 1, 64
• グルカゴン研究update　最も正確なサンドイッチELISA法の確立, ;, Jun. 2023, 56, 6, 732
• 視床下部室傍核ドーパミンニューロンの摂食行動における役割, ;;;;;, Nov. 2022, 28, Suppl., 287
• グルカゴン　生理作用,薬理作用,病態生理的意義,そして糖尿病・肥満症に対する診断と治療への応用, 北村 忠弘, Dec. 2023, 29, 3, 94
• 肥満における5G(GLP-1、GIP、Glucagon、Ghrelin、Gut hormone)　基礎研究と臨床研究　最も正確なグルカゴンサンドイッチELISA法　臨床検査における有用性(The 5Gs in Obesity(GLP-1, GIP, Glucagon, Ghrelin and Gut hormone): Basic and Clinical Research　The most accurate glucagon sandwich ELISA; its usefulness for clinical examination), 北村 忠弘, Nov. 2023, 29, 合同学術集会抄録集, 156
• 脳科学が紐解く新しい肥満症克服ターゲット　AgRPニューロンのFTOによる体重制御機構, ;;;;;;;;;;, Nov. 2023, 29, 合同学術集会抄録集, 172
• 視床下部室傍核ドーパミンニューロンによる過食誘導機構の解明, ;;;;, Nov. 2023, 29, 合同学術集会抄録集, 293
• Methyl α-D-Glucopyranosideによる糖・脂質代謝改善メカニズムの解明, ;;;;;;, Nov. 2023, 29, 合同学術集会抄録集, 298
• 視床下部室傍核ドーパミンニューロンの高脂肪食による影響と役割, ;;;;, Oct. 2022, 10, 2, 70

MISC

• The Transcription Factor COUP-TFII Is Negatively Regulated by Insulin and Glucose via Foxo1-and ChREBP-Controlled Pathways, Anais Perilhou; Cecile Tourrel-Cuzin; Ilham Kharroubi; Carole Henique; Veronique Fauveau; Tadahiro Kitamura; Christophe Magnan; Catherine Postic; Carina Prip-Buus; Mireille Vasseur-Cognet, Nov. 2008, MOLECULAR AND CELLULAR BIOLOGY, 28, 21, 6568, 6579

  DOI
• The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways., Anaïs Perilhou; Cécile Tourrel-Cuzin; Ilham Kharroubi; Carole Henique; Véronique Fauveau; Tadahiro Kitamura; Christophe Magnan; Catherine Postic; Carina Prip-Buus; Mireille Vasseur-Cognet, Nov. 2008, Molecular and cellular biology, 28, 21, 6568, 79

  DOI
• Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic beta-Cells and its role in promotion of insulin secretion and protection against diabetes., Masaki Kobayashi; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Yuriko Hayashi; Hisae Kobayashi; Tadahiro Kitamura; Takashi Matozaki, Nov. 2008, Endocrinology, 149, 11, 5662, 9

  DOI
• Expression of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 in Pancreatic beta-Cells and Its Role in Promotion of Insulin Secretion and Protection against Diabetes, Masaki Kobayashi; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Yuriko Hayashi; Hisae Kobayashi; Tadahiro Kitamura; Takashi Matozaki, Nov. 2008, ENDOCRINOLOGY, 149, 11, 5662, 5669

  DOI
• N-methyl-d-aspartate receptor coagonist d-serine suppresses intake of high-preference food., Tsutomu Sasaki; Yoshihiro Kinoshita; Sho Matsui; Shigeru Kakuta; Hiromi Yokota-Hashimoto; Kuni Kinoshita; Yusaku Iwasaki; Toshio Kinoshita; Toshihiko Yada; Naoji Amano; Tadahiro Kitamura, Sep. 2015, American journal of physiology. Regulatory, integrative and comparative physiology, 309, 5, R561-75, R575

  DOI
• N-methyl-D-aspartate receptor coagonist D-serine suppresses intake of high-preference food, Tsutomu Sasaki; Yoshihiro Kinoshita; Sho Matsui; Shigeru Kakuta; Hiromi Yokota-Hashimoto; Kuni Kinoshita; Yusaku Iwasaki; Toshio Kinoshita; Toshihiko Yada; Naoji Amano; Tadahiro Kitamura, Sep. 2015, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309, 5, R561, R575

  DOI
• A Mutant Allele Encoding DNA Binding-Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism, Joshua R. Cook; Michihiro Matsumoto; Alexander S. Banks; Tadahiro Kitamura; Kyoichiro Tsuchiya; Domenico Accili, Jun. 2015, DIABETES, 64, 6, 1951, 1965

  DOI
• A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism., Joshua R Cook; Michihiro Matsumoto; Alexander S Banks; Tadahiro Kitamura; Kyoichiro Tsuchiya; Domenico Accili, Jun. 2015, Diabetes, 64, 6, 1951, 65

  DOI
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue, Tsutomu Sasaki; Haruna Hiraga; Hiromi Yokota-Hashimoto; Tadahiro Kitamura, May 2015, ENDOCRINE JOURNAL, 62, 5, 469, 473

  DOI
• Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue., Tsutomu Sasaki; Haruna Hiraga; Hiromi Yokota-Hashimoto; Tadahiro Kitamura, 2015, Endocrine journal, 62, 5, 469, 73

  DOI
• Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice., Tsutomu Sasaki; Mitsutaka Kuroko; Sawako Sekine; Sho Matsui; Osamu Kikuchi; Vina Yanti Susanti; Masaki Kobayashi; Yoshinori Tanaka; Tomoyuki Yuasa; Tadahiro Kitamura, 2015, Endocrine journal, 62, 9, 787, 96

  DOI
• Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice, Tsutomu Sasaki; Mitsutaka Kuroko; Sawako Sekine; Sho Matsui; Osamu Kikuchi; Vina Yanti Susanti; Masaki Kobayashi; Yoshinori Tanaka; Tomoyuki Yuasa; Tadahiro Kitamura, Sep. 2015, ENDOCRINE JOURNAL, 62, 9, 787, 796

  DOI
• Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells, Jun Tanaka; Li Qiang; Alexander S. Banks; Carrie L. Welch; Michihiro Matsumoto; Tadahiro Kitamura; Yukari Ido-Kitamura; Ronald A. DePinho; Domenico Accili, Oct. 2009, DIABETES, 58, 10, 2344, 2354

  DOI
• Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells., Jun Tanaka; Li Qiang; Alexander S Banks; Carrie L Welch; Michihiro Matsumoto; Tadahiro Kitamura; Yukari Ido-Kitamura; Ronald A DePinho; Domenico Accili, Oct. 2009, Diabetes, 58, 10, 2344, 54

  DOI
• Genetic and biochemical pathways of beta-cell failure in type 2 diabetes, C. Talchai; H. V. Lin; T. Kitamura; D. Accili, Nov. 2009, DIABETES OBESITY & METABOLISM, 11, 38, 45

  DOI
• Genetic and biochemical pathways of beta-cell failure in type 2 diabetes, C. Talchai; H. V. Lin; T. Kitamura; D. Accili, Nov. 2009, DIABETES OBESITY & METABOLISM, 11, 38, 45

  DOI
• Dicer is required for maintaining adult pancreas., Sumiyo Morita; Akemi Hara; Itaru Kojima; Takuro Horii; Mika Kimura; Tadahiro Kitamura; Takahiro Ochiya; Katsumi Nakanishi; Ryo Matoba; Kenichi Matsubara; Izuho Hatada, 2009, PloS one, 4, 1, e4212

  DOI
• Dicer is required for maintaining adult pancreas., Sumiyo Morita; Akemi Hara; Itaru Kojima; Takuro Horii; Mika Kimura; Tadahiro Kitamura; Takahiro Ochiya; Katsumi Nakanishi; Ryo Matoba; Kenichi Matsubara; Izuho Hatada, 2009, PloS one, 4, 1, e4212

  DOI
• Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1., Tadahiro Kitamura; Yukari Ido Kitamura; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Ronald A Depinho; Domenico Accili, Aug. 2009, Molecular and cellular biology, 29, 16, 4417, 30

  DOI
• Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1, Tadahiro Kitamura; Yukari Ido Kitamura; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Ronald A. DePinho; Domenico Accili, Aug. 2009, MOLECULAR AND CELLULAR BIOLOGY, 29, 16, 4417, 4430

  DOI
• Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms., Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Shinji Hashimoto; Masayuki Okamoto; Motoharu Awazawa; Yukiko Okazaki; Mitsuru Ohsugi; Kazunori Inabe; Toshihiro Umehara; Masashi Yoshida; Masafumi Kakei; Tadahiro Kitamura; Ji Luo; Rohit N Kulkarni; C Ronald Kahn; Haruo Kasai; Lewis C Cantley; Takashi Kadowaki, 01 Dec. 2010, Cell metabolism, 12, 6, 619, 32

  DOI
• Class IA Phosphatidylinositol 3-Kinase in Pancreatic beta Cells Controls Insulin Secretion by Multiple Mechanisms, Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Shinji Hashimoto; Masayuki Okamoto; Motoharu Awazawa; Yukiko Okazaki; Mitsuru Ohsugi; Kazunori Inabe; Toshihiro Umehara; Masashi Yoshida; Masafumi Kakei; Tadahiro Kitamura; Ji Luo; Rohit N. Kulkarni; C. Ronald Kahn; Haruo Kasai; Lewis C. Cantley; Takashi Kadowaki, Dec. 2010, CELL METABOLISM, 12, 6, 619, 632

  DOI
• Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism, Michihiro Matsumoto; Seongah Han; Tadahiro Kitamura; Domenico Accili, Sep. 2006, JOURNAL OF CLINICAL INVESTIGATION, 116, 9, 2464, 2472

  DOI
• Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism., Michihiro Matsumoto; Seongah Han; Tadahiro Kitamura; Domenico Accili, Sep. 2006, The Journal of clinical investigation, 116, 9, 2464, 72

  DOI
• Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes., Nicole A Sherry; Jake A Kushner; Mariela Glandt; Tadahiro Kitamura; Anne-Marie B Brillantes; Kevan C Herold, Dec. 2006, Diabetes, 55, 12, 3238, 45

  DOI
• Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes, Nicole A. Sherry; Jake A. Kushner; Mariela Glandt; Tadahiro Kitamura; Anne-Marie B. Brillantes; Kevan C. Herold, Dec. 2006, DIABETES, 55, 12, 3238, 3245

  DOI
• Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake., Tadahiro Kitamura; Yun Feng; Yukari Ido Kitamura; Streamson C Chua Jr; Allison W Xu; Gregory S Barsh; Luciano Rossetti; Domenico Accili, May 2006, Nature medicine, 12, 5, 534, 40

  DOI
• Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake, Tadahiro Kitamura; Yun Feng; Yukari Ido Kitamura; Streamson C. Chua; Allison W. Xu; Gregory S. Barsh; Luciano Rossetti; Domenico Accili, May 2006, NATURE MEDICINE, 12, 5, 534, 540

  DOI
• Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo, Kinh-Tung T. Nguyen; Panteha Tajmir; Chia Hung Lin; Nicole Liadis; Xu-Dong Zhu; Mohammed Eweida; Gunce Tolasa-Karaman; Fang Cai; Rennian Wang; Tadahiro Kitamura; Denise D. Belsham; Michael B. Wheeler; Akira Suzuki; Tak W. Mak; Minna Woo, Jun. 2006, MOLECULAR AND CELLULAR BIOLOGY, 26, 12, 4511, 4518

  DOI
• Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo., Kinh-Tung T Nguyen; Panteha Tajmir; Chia Hung Lin; Nicole Liadis; Xu-Dong Zhu; Mohammed Eweida; Gunce Tolasa-Karaman; Fang Cai; Rennian Wang; Tadahiro Kitamura; Denise D Belsham; Michael B Wheeler; Akira Suzuki; Tak W Mak; Minna Woo, Jun. 2006, Molecular and cellular biology, 26, 12, 4511, 8

  DOI
• The Forkhead transcription factor Fox01 regulates proliferation and transdifferentiation of hepatic stellate cells, Masayuki Adachi; Yosuke Osawa; Hiroshi Uchinami; Tadahiro Kitamura; Domenico Accili; David A. Brenner, Apr. 2007, GASTROENTEROLOGY, 132, 4, 1434, 1446

  DOI
• The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells., Masayuki Adachi; Yosuke Osawa; Hiroshi Uchinami; Tadahiro Kitamura; Domenico Accili; David A Brenner, Apr. 2007, Gastroenterology, 132, 4, 1434, 46

  DOI
• A Foxo/Notch pathway controls myogenic differentiation and fiber type specification, Tadahiro Kitamura; Yukari Ido Kitamura; Yasuhiro Funahashi; Carrie J. Shawber; Diego H. Castrillon; Ramya Kollipara; Ronald A. DePinho; Jan Kitajewski; Domenico Accili, Sep. 2007, JOURNAL OF CLINICAL INVESTIGATION, 117, 9, 2477, 2485

  DOI
• A Foxo/Notch pathway controls myogenic differentiation and fiber type specification., Tadahiro Kitamura; Yukari Ido Kitamura; Yasuhiro Funahashi; Carrie J Shawber; Diego H Castrillon; Ramya Kollipara; Ronald A DePinho; Jan Kitajewski; Domenico Accili, Sep. 2007, The Journal of clinical investigation, 117, 9, 2477, 85

  DOI
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction., Yukari Ido Kitamura; Tadahiro Kitamura; Jan-Philipp Kruse; Jeffrey C Raum; Roland Stein; Wei Gu; Domenico Accili, Sep. 2005, Cell metabolism, 2, 3, 153, 63

  DOI
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction, YI Kitamura; T Kitamura; JP Kruse; JC Raum; R Stein; W Gu; D Accili, Sep. 2005, CELL METABOLISM, 2, 3, 153, 163

  DOI
• Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance, Hye-Jin Kim; Masaki Kobayashi; Tsutomu Sasaki; Osamu Kikuchi; Kosuke Amano; Tomoya Kitazumi; Yong-Soo Lee; Hiromi Yokota-Hashimoto; Vina Yanti Susanti; Yukari Ido Kitamura; Jun Nakae; Tadahiro Kitamura, Feb. 2012, ENDOCRINOLOGY, 153, 2, 659, 671

  DOI
• Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance., Hye-Jin Kim; Masaki Kobayashi; Tsutomu Sasaki; Osamu Kikuchi; Kosuke Amano; Tomoya Kitazumi; Yong-Soo Lee; Hiromi Yokota-Hashimoto; Vina Yanti Susanti; Yukari Ido Kitamura; Jun Nakae; Tadahiro Kitamura, Feb. 2012, Endocrinology, 153, 2, 659, 71

  DOI
• Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion., Takashi Nakakura; Chihiro Mogi; Masayuki Tobo; Hideaki Tomura; Koichi Sato; Masaki Kobayashi; Hiroshi Ohnishi; Shigeyasu Tanaka; Mitsutoshi Wayama; Tetsuya Sugiyama; Tadahiro Kitamura; Akihiro Harada; Fumikazu Okajima, Sep. 2012, Endocrinology, 153, 9, 4171, 80

  DOI
• Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion, Takashi Nakakura; Chihiro Mogi; Masayuki Tobo; Hideaki Tomura; Koichi Sato; Masaki Kobayashi; Hiroshi Ohnishi; Shigeyasu Tanaka; Mitsutoshi Wayama; Tetsuya Sugiyama; Tadahiro Kitamura; Akihiro Harada; Fumikazu Okajima, Sep. 2012, ENDOCRINOLOGY, 153, 9, 4171, 4180

  DOI
• Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation, Yukari Ido-Kitamura; Tsutomu Sasaki; Masaki Kobayashi; Hye-Jin Kim; Yong-Soo Lee; Osamu Kikuchi; Hiromi Yokota-Hashimoto; Katsumi Iizuka; Domenico Accili; Tadahiro Kitamura, Oct. 2012, PLOS ONE, 7, 10, e47231

  DOI
• Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation., Yukari Ido-Kitamura; Tsutomu Sasaki; Masaki Kobayashi; Hye-Jin Kim; Yong-Soo Lee; Osamu Kikuchi; Hiromi Yokota-Hashimoto; Katsumi Iizuka; Domenico Accili; Tadahiro Kitamura, 2012, PloS one, 7, 10, e47231

  DOI
• FoxO1 gain of function in the pancreas causes glucose intolerance, polycystic pancreas, and islet hypervascularization., Osamu Kikuchi; Masaki Kobayashi; Kosuke Amano; Tsutomu Sasaki; Tomoya Kitazumi; Hye-Jin Kim; Yong-Soo Lee; Hiromi Yokota-Hashimoto; Yukari-Ido Kitamura; Tadahiro Kitamura, 2012, PloS one, 7, 2, e32249

  DOI
• FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization, Osamu Kikuchi; Masaki Kobayashi; Kosuke Amano; Tsutomu Sasaki; Tomoya Kitazumi; Hye-Jin Kim; Yong-Soo Lee; Hiromi Yokota-Hashimoto; Yukari-Ido Kitamura; Tadahiro Kitamura, Feb. 2012, PLOS ONE, 7, 2, e32249

  DOI
• Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis, Koichi Hasegawa; Tomohiro Kawahara; Kazushiro Fujiwara; Mayumi Shimpuku; Tsutomu Sasaki; Tadahiro Kitamura; Kazuaki Yoshikawa, Apr. 2012, JOURNAL OF NEUROSCIENCE, 32, 16, 5562, 5572

  DOI
• Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis., Koichi Hasegawa; Tomohiro Kawahara; Kazushiro Fujiwara; Mayumi Shimpuku; Tsutomu Sasaki; Tadahiro Kitamura; Kazuaki Yoshikawa, 18 Apr. 2012, The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 16, 5562, 72

  DOI
• FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice., Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Hye-Jin Kim; Hiromi Yokota-Hashimoto; Yong-Soo Lee; Kosuke Amano; Tomoya Kitazumi; Vina Yanti Susanti; Yukari Ido Kitamura; Tadahiro Kitamura, 01 Mar. 2012, American journal of physiology. Endocrinology and metabolism, 302, 5, E603-13, E613

  DOI
• FoxO1 as a double-edged sword in the pancreas: analysis of pancreas-and beta-cell-specific FoxO1 knockout mice, Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Hye-Jin Kim; Hiromi Yokota-Hashimoto; Yong-Soo Lee; Kosuke Amano; Tomoya Kitazumi; Vina Yanti Susanti; Yukari Ido Kitamura; Tadahiro Kitamura, Mar. 2012, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 302, 5, E603, E613

  DOI
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation, Chutima Talchai; Shouhong Xuan; Tadahiro Kitamura; Ronald A. DePinho; Domenico Accili, Apr. 2012, NATURE GENETICS, 44, 4, 406, U213

  DOI
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation., Chutima Talchai; Shouhong Xuan; Tadahiro Kitamura; Ronald A DePinho; Domenico Accili, 11 Mar. 2012, Nature genetics, 44, 4, 406, 12

  DOI
• Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1, J Nakai; WH Biggs; T Kitamura; WK Cavenee; CVE Wright; KC Arden; D Accili, Oct. 2002, NATURE GENETICS, 32, 2, 245, 253

  DOI
• Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1., Jun Nakae; William H Biggs 3rd; Tadahiro Kitamura; Webster K Cavenee; Christopher V E Wright; Karen C Arden; Domenico Accili, Oct. 2002, Nature genetics, 32, 2, 245, 53

  DOI
• The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth., Tadahiro Kitamura; Jun Nakae; Yukari Kitamura; Yoshiaki Kido; William H Biggs 3rd; Christopher V E Wright; Morris F White; Karen C Arden; Domenico Accili, Dec. 2002, The Journal of clinical investigation, 110, 12, 1839, 47

  DOI
• The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth, T Kitamura; J Nakae; Y Kitamura; Y Kido; WH Biggs; CVE Wright; MF White; KC Arden; D Accili, Dec. 2002, JOURNAL OF CLINICAL INVESTIGATION, 110, 12, 1839, 1847

  DOI
• Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor, SH Xuan; T Kitamura; J Nakae; K Politi; Y Kido; PE Fisher; M Morroni; S Cinti; MF White; PL Herrera; D Accili; A Efstratiadis, Oct. 2002, JOURNAL OF CLINICAL INVESTIGATION, 110, 7, 1011, 1019

  DOI
• Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor., Shouhong Xuan; Tadahiro Kitamura; Jun Nakae; Katerina Politi; Yoshiaki Kido; Peter E Fisher; Manrico Morroni; Saverio Cinti; Morris F White; Pedro L Herrera; Domenico Accili; Argiris Efstratiadis, Oct. 2002, The Journal of clinical investigation, 110, 7, 1011, 9

  DOI
• The forkhead transcription factor Foxo1 regulates adipocyte differentiation, J Nakae; T Kitamura; Y Kitamura; WH Biggs; KC Arden; D Accili, Jan. 2003, DEVELOPMENTAL CELL, 4, 1, 119, 129

  DOI
• The forkhead transcription factor Foxo1 regulates adipocyte differentiation., Jun Nakae; Tadahiro Kitamura; Yukari Kitamura; William H Biggs 3rd; Karen C Arden; Domenico Accili, Jan. 2003, Developmental cell, 4, 1, 119, 29

  DOI
• Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors., Marta L Hribal; Jun Nakae; Tadahiro Kitamura; John R Shutter; Domenico Accili, 18 Aug. 2003, The Journal of cell biology, 162, 4, 535, 41

  DOI
• Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors, ML Hribal; J Nakae; T Kitamura; Shutter, JR; D Accili, Aug. 2003, JOURNAL OF CELL BIOLOGY, 162, 4, 535, 541

  DOI
• Insulin receptor knockout mice., Tadahiro Kitamura; C Ronald Kahn; Domenico Accili, 2003, Annual review of physiology, 65, 313, 32

  DOI
• Insulin receptor knockout mice, T Kitamura; CR Kahn; E Accili, 2003, ANNUAL REVIEW OF PHYSIOLOGY, 65, 313, 332, Book review

  DOI
• Transgenic rescue of insulin receptor-deficient mice, H Okamoto; J Nakae; T Kitamura; BC Park; Dragatsis, I; D Accili, Jul. 2004, JOURNAL OF CLINICAL INVESTIGATION, 114, 2, 214, 223

  DOI
• Transgenic rescue of insulin receptor-deficient mice., Haruka Okamoto; Jun Nakae; Tadahiro Kitamura; Byung-Chul Park; Ioannis Dragatsis; Domenico Accili, Jul. 2004, The Journal of clinical investigation, 114, 2, 214, 23

  DOI
• DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes, Masashi Kuroda; Ayako Tominaga; Kasumi Nakagawa; Misa Nishiguchi; Mayu Sebe; Yumiko Miyatake; Tadahiro Kitamura; Rie Tsutsumi; Nagakatsu Harada; Yutaka Nakaya; Hiroshi Sakaue, Aug. 2016, PLOS ONE, 11, 8, e0160532

  DOI
• DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes., Masashi Kuroda; Ayako Tominaga; Kasumi Nakagawa; Misa Nishiguchi; Mayu Sebe; Yumiko Miyatake; Tadahiro Kitamura; Rie Tsutsumi; Nagakatsu Harada; Yutaka Nakaya; Hiroshi Sakaue, 2016, PloS one, 11, 8, e0160532

  DOI
• Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine, Tsutomu Sasaki; Sho Matsui; Tadahiro Kitamura, Jul. 2016, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17, 7, 1081, Book review

  DOI
• Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2)., Simona S Ghanem; Garrett Heinrich; Sumona G Lester; Verena Pfeiffer; Sumit Bhattacharya; Payal R Patel; Anthony M DeAngelis; Tong Dai; Sadeesh K Ramakrishnan; Zachary N Smiley; Dae Y Jung; Yongjin Lee; Tadahiro Kitamura; Suleyman Ergun; Rohit N Kulkarni; Jason K Kim; David R Giovannucci; Sonia M Najjar, 08 Jan. 2016, The Journal of biological chemistry, 291, 2, 980, 8

  DOI
• Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigenrelated Cell Adhesion Molecule 2 (CEACAM2), Simona S. Ghanem; Garrett Heinrich; Sumona G. Lester; Verena Pfeiffer; Sumit Bhattacharya; Payal R. Patel; Anthony M. DeAngelis; Tong Dai; Sadeesh K. Ramakrishnan; Zachary N. Smiley; Dae Y. Jung; Yongjin Lee; Tadahiro Kitamura; Suleyman Ergun; Rohit N. Kulkarni; Jason K. Kim; David R. Giovannucci; Sonia M. Najjar, Jan. 2016, JOURNAL OF BIOLOGICAL CHEMISTRY, 291, 2, 980, 988

  DOI
• Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness, Daisuke Kohno; Miho Koike; Yuzo Ninomiya; Itaru Kojima; Tadahiro Kitamura; Toshihiko Yada, Nov. 2016, FRONTIERS IN NEUROSCIENCE, 10, 502

  DOI
• Sweet Taste Receptor Serves to Activate Glucose- and Leptin-Responsive Neurons in the Hypothalamic Arcuate Nucleus and Participates in Glucose Responsiveness, Daisuke Kohno; Miho Koike; Yuzo Ninomiya; Itaru Kojima; Tadahiro Kitamura; Toshihiko Yada, Nov. 2016, FRONTIERS IN NEUROSCIENCE, 10, 502

  DOI
• Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells., Masataka Kunii; Mica Ohara-Imaizumi; Noriko Takahashi; Masaki Kobayashi; Ryosuke Kawakami; Yasumitsu Kondoh; Takeshi Shimizu; Siro Simizu; Bangzhong Lin; Kazuto Nunomura; Kyota Aoyagi; Mitsuyo Ohno; Masaki Ohmuraya; Takashi Sato; Shin-Ichiro Yoshimura; Ken Sato; Reiko Harada; Yoon-Jeong Kim; Hiroyuki Osada; Tomomi Nemoto; Haruo Kasai; Tadahiro Kitamura; Shinya Nagamatsu; Akihiro Harada, 10 Oct. 2016, The Journal of cell biology, 215, 1, 121, 138

  DOI
• Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells., Masataka Kunii; Mica Ohara-Imaizumi; Noriko Takahashi; Masaki Kobayashi; Ryosuke Kawakami; Yasumitsu Kondoh; Takeshi Shimizu; Siro Simizu; Bangzhong Lin; Kazuto Nunomura; Kyota Aoyagi; Mitsuyo Ohno; Masaki Ohmuraya; Takashi Sato; Shin-Ichiro Yoshimura; Ken Sato; Reiko Harada; Yoon-Jeong Kim; Hiroyuki Osada; Tomomi Nemoto; Haruo Kasai; Tadahiro Kitamura; Shinya Nagamatsu; Akihiro Harada, 10 Oct. 2016, The Journal of cell biology, 215, 1, 121, 138

  DOI
• Genetic Defect in Phospholipase C delta 1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis, Masayuki Hirata; Mutsumi Suzuki; Rika Ishii; Reiko Satow; Takafumi Uchida; Tomoya Kitazumi; Tsutomu Sasaki; Tadahiro Kitamura; Hideki Yamaguchi; Yoshikazu Nakamura; Kiyoko Fukami, Jul. 2011, DIABETES, 60, 7, 1926, 1937

  DOI
• Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis., Masayuki Hirata; Mutsumi Suzuki; Rika Ishii; Reiko Satow; Takafumi Uchida; Tomoya Kitazumi; Tsutomu Sasaki; Tadahiro Kitamura; Hideki Yamaguchi; Yoshikazu Nakamura; Kiyoko Fukami, Jul. 2011, Diabetes, 60, 7, 1926, 37

  DOI
• Protection Against High-Fat Diet-Induced Obesity in Helz2-Deficient Male Mice Due to Enhanced Expression of Hepatic Leptin Receptor, Satoshi Yoshino; Tetsurou Satoh; Masanobu Yamada; Koshi Hashimoto; Takuya Tomaru; Akiko Katano-Toki; Satoru Kakizaki; Shuichi Okada; Hiroyuki Shimizu; Atsushi Ozawa; Takafumi Tuchiya; Hayato Ikota; Yoichi Nakazato; Munemasa Mori; Takashi Matozaki; Tsutomu Sasaki; Tadahiro Kitamura; Masatomo Mori, Sep. 2014, ENDOCRINOLOGY, 155, 9, 3459, 3472

  DOI
• Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor., Satoshi Yoshino; Tetsurou Satoh; Masanobu Yamada; Koshi Hashimoto; Takuya Tomaru; Akiko Katano-Toki; Satoru Kakizaki; Shuichi Okada; Hiroyuki Shimizu; Atsushi Ozawa; Takafumi Tuchiya; Hayato Ikota; Yoichi Nakazato; Munemasa Mori; Takashi Matozaki; Tsutomu Sasaki; Tadahiro Kitamura; Masatomo Mori, Sep. 2014, Endocrinology, 155, 9, 3459, 72

  DOI
• ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription., Yong-Soo Lee; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Hiromi Yokota-Hashimoto; Vina Yanti Susanti; Yukari Ido Kitamura; Tadahiro Kitamura, 2014, Endocrine journal, 61, 1, 85, 90

  DOI
• ATF3 expression is induced by low glucose in pancreatic alpha and beta cells and regulates glucagon but not insulin gene transcription, Yong-Soo Lee; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Hiromi Yokota-Hashimoto; Vina Yanti Susanti; Yukari Ido Kitamura; Tadahiro Kitamura, Jan. 2014, ENDOCRINE JOURNAL, 61, 1, 85, 90

  DOI
• Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice., Taro Usui; Kazuo Kajita; Toshiko Kajita; Ichiro Mori; Takayuki Hanamoto; Takahide Ikeda; Hideyuki Okada; Koichiro Taguchi; Yoshihiko Kitada; Hiroyuki Morita; Tsutomu Sasaki; Tadahiro Kitamura; Takashi Sato; Itaru Kojima; Tatsuo Ishizuka, 21 May 2014, FEBS letters, 588, 10, 1935, 41

  DOI
• Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice, Taro Usui; Kazuo Kajita; Toshiko Kajita; Ichiro Mori; Takayuki Hanamoto; Takahide Ikeda; Hideyuki Okada; Koichiro Taguchi; Yoshihiko Kitada; Hiroyuki Morita; Tsutomu Sasaki; Tadahiro Kitamura; Takashi Sato; Itaru Kojima; Tatsuo Ishizuka, May 2014, FEBS LETTERS, 588, 10, 1935, 1941

  DOI
• Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis., Daisuke Kohno; Syann Lee; Matthew J Harper; Ki Woo Kim; Hideyuki Sone; Tsutomu Sasaki; Tadahiro Kitamura; Guoping Fan; Joel K Elmquist, 12 Nov. 2014, The Journal of neuroscience : the official journal of the Society for Neuroscience, 34, 46, 15288, 96

  DOI
• Dnmt3a in Sim1 Neurons Is Necessary for Normal Energy Homeostasis, Daisuke Kohno; Syann Lee; Matthew J. Harper; Ki Woo Kim; Hideyuki Sone; Tsutomu Sasaki; Tadahiro Kitamura; Guoping Fan; Joel K. Elmquist, Nov. 2014, JOURNAL OF NEUROSCIENCE, 34, 46, 15288, 15296

  DOI
• TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass., Iseki Takamoto; Naoto Kubota; Keizo Nakaya; Katsuyoshi Kumagai; Shinji Hashimoto; Tetsuya Kubota; Mariko Inoue; Eiji Kajiwara; Hisayuki Katsuyama; Atsushi Obata; Yoshitaka Sakurai; Masahiko Iwamoto; Tadahiro Kitamura; Kohjiro Ueki; Takashi Kadowaki, Mar. 2014, Diabetologia, 57, 3, 542, 53

  DOI
• TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass., Iseki Takamoto; Naoto Kubota; Keizo Nakaya; Katsuyoshi Kumagai; Shinji Hashimoto; Tetsuya Kubota; Mariko Inoue; Eiji Kajiwara; Hisayuki Katsuyama; Atsushi Obata; Yoshitaka Sakurai; Masahiko Iwamoto; Tadahiro Kitamura; Kohjiro Ueki; Takashi Kadowaki, Mar. 2014, Diabetologia, 57, 3, 542, 53

  DOI
• FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification., Yasutomi Kamei; Maki Hattori; Yukino Hatazawa; Tomomi Kasahara; Masanobu Kanou; Sayaka Kanai; Xunmei Yuan; Takayoshi Suganami; Wouter H Lamers; Tadahiro Kitamura; Yoshihiro Ogawa, 15 Sep. 2014, American journal of physiology. Endocrinology and metabolism, 307, 6, E485-93, E493

  DOI
• FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3 '-UTR: possible contribution to ammonia detoxification, Yasutomi Kamei; Maki Hattori; Yukino Hatazawa; Tomomi Kasahara; Masanobu Kanou; Sayaka Kanai; Xunmei Yuan; Takayoshi Suganami; Wouter H. Lamers; Tadahiro Kitamura; Yoshihiro Ogawa, Sep. 2014, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 307, 6, E485, E493

  DOI
• Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice., Vina Yanti Susanti; Tsutomu Sasaki; Hiromi Yokota-Hashimoto; Sho Matsui; Yong-Soo Lee; Osamu Kikuchi; Mayumi Shimpuku; Hye-Jin Kim; Masaki Kobayashi; Tadahiro Kitamura, Oct. 2014, Obesity (Silver Spring, Md.), 22, 10, 2115, 9

  DOI
• Sirt1 Rescues the Obesity Induced by Insulin-Resistant Constitutively-Nuclear FoxO1 in POMC Neurons of Male Mice, Vina Yanti Susanti; Tsutomu Sasaki; Hiromi Yokota-Hashimoto; Sho Matsui; Yong-Soo Lee; Osamu Kikuchi; Mayumi Shimpuku; Hye-Jin Kim; Masaki Kobayashi; Tadahiro Kitamura, Oct. 2014, OBESITY, 22, 10, 2115, 2119

  DOI
• Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice, Tsutomu Sasaki; Osamu Kikuchi; Mayumi Shimpuku; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Ryo Taguchi; Nobuyuki Shibusawa; Takashi Sato; Lijun Tang; Kosuke Amano; Tomoya Kitazumi; Mitsutaka Kuroko; Yuki Fujita; Jun Maruyama; Yong-soo Lee; Masaki Kobayashi; Takashi Nakagawa; Yasuhiko Minokoshi; Akihiro Harada; Masanobu Yamada; Tadahiro Kitamura, Apr. 2014, DIABETOLOGIA, 57, 4, 819, 831

  DOI
• Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice., Tsutomu Sasaki; Osamu Kikuchi; Mayumi Shimpuku; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Ryo Taguchi; Nobuyuki Shibusawa; Takashi Sato; Lijun Tang; Kosuke Amano; Tomoya Kitazumi; Mitsutaka Kuroko; Yuki Fujita; Jun Maruyama; Yong-Soo Lee; Masaki Kobayashi; Takashi Nakagawa; Yasuhiko Minokoshi; Akihiro Harada; Masanobu Yamada; Tadahiro Kitamura, Apr. 2014, Diabetologia, 57, 4, 819, 31

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test., Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, 05 Nov. 2017, European journal of pharmacology, 814, 130, 137

  DOI
• Intraperitoneal injection of d-serine inhibits high-fat diet intake and preference in male mice., Tsutomu Sasaki; Yasunobu Yasoshima; Sho Matsui; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Tadahiro Kitamura, 01 Nov. 2017, Appetite, 118, 120, 128

  DOI
• Intraperitoneal injection of D-serine inhibits high-fat diet intake and preference in male mice, Tsutomu Sasaki; Yasunobu Yasoshima; Sho Matsui; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Tadahiro Kitamura, Nov. 2017, APPETITE, 118, 120, 128

  DOI
• Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: comparison with commercially available immunoassays., Atsushi Miyachi; Masaki Kobayashi; Eri Mieno; Moritaka Goto; Kenichi Furusawa; Takashi Inagaki; Tadahiro Kitamura, Oct. 2017, Analytical and bioanalytical chemistry, 409, 25, 5911, 5918

  DOI
• Accurate analytical method for human plasma glucagon levels using liquid chromatography-high resolution mass spectrometry: comparison with commercially available immunoassays, Atsushi Miyachi; Masaki Kobayashi; Eri Mieno; Moritaka Goto; Kenichi Furusawa; Takashi Inagaki; Tadahiro Kitamura, Oct. 2017, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409, 25, 5911, 5918

  DOI
• Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-beta expression, Ayako Fukunaka; Toshiyuki Fukada; Jinhyuk Bhin; Luka Suzuki; Takamasa Tsuzuki; Yuri Takamine; Bum-Ho Bin; Toshinori Yoshihara; Noriko Ichinoseki-Sekine; Hisashi Naito; Takeshi Miyatsuka; Shinzaburo Takamiya; Tsutomu Sasaki; Takeshi Inagaki; Tadahiro Kitamura; Shingo Kajimura; Hirotaka Watada; Yoshio Fujitani, Aug. 2017, PLOS GENETICS, 13, 8, e1006950

  DOI
• Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-beta expression, Ayako Fukunaka; Toshiyuki Fukada; Jinhyuk Bhin; Luka Suzuki; Takamasa Tsuzuki; Yuri Takamine; Bum-Ho Bin; Toshinori Yoshihara; Noriko Ichinoseki-Sekine; Hisashi Naito; Takeshi Miyatsuka; Shinzaburo Takamiya; Tsutomu Sasaki; Takeshi Inagaki; Tadahiro Kitamura; Shingo Kajimura; Hirotaka Watada; Yoshio Fujitani, Aug. 2017, PLOS GENETICS, 13, 8, e1006950

  DOI
• Intracerebroventricular injection of ghrelin decreases wheel running activity in rats, Yumiko Miyatake; Tetsuya Shiuchi; Kazuaki Mawatari; Satomi Toda; Yasuko Taniguchi; Akari Futami; Fukiko Sato; Masashi Kuroda; Mayu Sebe; Rie Tsutsumi; Nagakatsu Harada; Yasuhiko Minokoshi; Tadahiro Kitamura; Koro Gotoh; Masaki Ueno; Yutaka Nakaya; Hiroshi Sakaue, Jan. 2017, PEPTIDES, 87, 12, 19

  DOI
• Intracerebroventricular injection of ghrelin decreases wheel running activity in rats., Yumiko Miyatake; Tetsuya Shiuchi; Kazuaki Mawatari; Satomi Toda; Yasuko Taniguchi; Akari Futami; Fukiko Sato; Masashi Kuroda; Mayu Sebe; Rie Tsutsumi; Nagakatsu Harada; Yasuhiko Minokoshi; Tadahiro Kitamura; Koro Gotoh; Masaki Ueno; Yutaka Nakaya; Hiroshi Sakaue, Jan. 2017, Peptides, 87, 12, 19

  DOI
• Role of Akt in growth and survival of PANC-1 pancreatic cancer cells, Z Yao; Y Okabayashi; Y Yutsudo; T Kitamura; W Ogawa; M Kasuga, Jan. 2002, PANCREAS, 24, 1, 42, 46

  DOI
• Role of FoxO proteins in pancreatic beta cells, Tadahiro Kitamura; Yukari Ido Kitamura, Aug. 2007, ENDOCRINE JOURNAL, 54, 4, 507, 515, Book review

  DOI
• The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle, Yoshihiro Yamazaki; Yasutomi Kamei; Satoshi Sugita; Fumiko Akaike; Sayaka Kanai; Shinji Miura; Yukio Hirata; Bruce R. Troen; Tadahiro Kitamura; Ichizo Nishino; Takayoshi Suganami; Osamu Ezaki; Yoshihiro Ogawa, Mar. 2010, ENDOCRINE JOURNAL, 57, 1, S350, S350, Summary international conference

  DOI
• Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP, Tsutomu Sasaki; Hye-jin Kim; Masaki Kobayashi; Yukari-Ido Kitamura; Hiromi Yokota-Hashimoto; Tetsuya Shiuchi; Yasuhiko Minokoshi; Tadahiro Kitamura, 2010, NEUROSCIENCE RESEARCH, 68, 6, E77, E77, Summary international conference

  DOI
• iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta cells: involvement of GSK-3b, Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M, 2011, J. Biol. Chem, 286, 33, 29388
• A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting, Mas Rizky A. A. Syamsunarno; Tatsuya Iso; Hirofumi Hanaoka; Aiko Yamaguchi; Masaru Obokata; Norimichi Koitabashi; Kosaku Goto; Takako Hishiki; Yoshiko Nagahata; Hiroki Matsui; Motoaki Sano; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Kazuhisa Maeda; Masami Murakami; Tadahiro Kitamura; Makoto Suematsu; Yoshito Tsushima; Keigo Endo; Goekhan S. Hotamisligil; Masahiko Kurabayashi, Nov. 2013, PLOS ONE, 8, 11, e79386

  DOI
• Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice, Lee, Y. -S; Sasaki, T; Kobayashi, M; Kikuchi, O; Kim, H. -J; Yokota-Hashimoto, H; Shimpuku, M; Susanti, V. -Y; Ido-Kitamura, Y; Kimura, K; Inoue, H; Tanaka-Okamoto, M; Ishizaki, H; Miyoshi, J; Ohya, S; Tanaka, Y; Kitajima, S; Kitamura, T, 2013, DIABETOLOGIA, 56, 6, 1383, 1393

  DOI
• Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced beta-cell damage and diabetes in mice, Makiko Fukaya; Yoshiaki Tamura; Yuko Chiba; Toshihiro Tanioka; Ji Mao; Yoko Inoue; Marina Yamada; Christian Waeber; Yukari Ido-Kitamura; Tadahiro Kitamura; Masao Kaneki, Dec. 2013, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 442, 1-2, 92, 98

  DOI
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates, Tsutomu Sasaki; Mayumi Shimpuku; Tomoya Kitazumi; Haruna Hiraga; Yuko Nakagawa; Hiroshi Shibata; Yuko Okamatsu-Ogura; Osamu Kikuchi; Hye-jin Kim; Yuki Fujita; Jun Maruyama; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Masayuki Saito; Tadahiro Kitamura, Oct. 2013, ENDOCRINE JOURNAL, 60, 10, 1117, 1129

  DOI
• The role of FOXO1 in β-cell failure and type 2 diabetes mellitus., Tadahiro Kitamura, Oct. 2013, Nature reviews. Endocrinology, 9, 10, 615, 23

  DOI
• A novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells., Yosuke Masubuchi; Yuko Nakagawa; Jinhui Ma; Tsutomu Sasaki; Tadahiro Kitamura; Yoritsuna Yamamoto; Hitoshi Kurose; Itaru Kojima; Hiroshi Shibata, 2013, PloS one, 8, 1, e54500

  DOI
• Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine., Tsutomu Sasaki; Sho Matsui; Tadahiro Kitamura, 07 Jul. 2016, International journal of molecular sciences, 17, 7, 1081

  DOI
• Role of Akt in growth and survival of PANC-1 pancreatic cancer cells., Zan Yao; Yoshinori Okabayashi; Yoshihiro Yutsudo; Tadahiro Kitamura; Wataru Ogawa; Masato Kasuga, Jan. 2002, Pancreas, 24, 1, 42, 6

  DOI
• Role of FoxO Proteins in Pancreatic beta Cells., Tadahiro Kitamura; Yukari Ido Kitamura, Aug. 2007, Endocrine journal, 54, 4, 507, 15

  DOI
• The cathepsin L gene is a direct target of FOXO1 in the skeletal muscle, Yoshihiro Yamazaki; Yasutomi Kamei; Satoshi Sugita; Fumiko Akaike; Sayaka Kanai; Shinji Miura; Yukio Hirata; Bruce R. Troen; Tadahiro Kitamura; Ichizo Nishino; Takayoshi Suganami; Osamu Ezaki; Yoshihiro Ogawa, Mar. 2010, ENDOCRINE JOURNAL, 57, 1, S350, S350, Summary international conference

  DOI
• Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP, Tsutomu Sasaki; Hye-jin Kim; Masaki Kobayashi; Yukari-Ido Kitamura; Hiromi Yokota-Hashimoto; Tetsuya Shiuchi; Yasuhiko Minokoshi; Tadahiro Kitamura, 2010, NEUROSCIENCE RESEARCH, 68, 6, E77, E77, Summary international conference

  DOI
• iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta cells: involvement of GSK-3b, Tanioka T; Tamura Y; Fukaya M; Shinozaki S; Mao J; Kim M; Shimizu N; Kitamura T; Kaneki M, 2011, 286, 33, 29388
• A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting., Mas Rizky A A Syamsunarno; Tatsuya Iso; Hirofumi Hanaoka; Aiko Yamaguchi; Masaru Obokata; Norimichi Koitabashi; Kosaku Goto; Takako Hishiki; Yoshiko Nagahata; Hiroki Matsui; Motoaki Sano; Masaki Kobayashi; Osamu Kikuchi; Tsutomu Sasaki; Kazuhisa Maeda; Masami Murakami; Tadahiro Kitamura; Makoto Suematsu; Yoshito Tsushima; Keigo Endo; Gökhan S Hotamisligil; Masahiko Kurabayashi, 2013, PloS one, 8, 11, e79386

  DOI
• Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice, Y. S. Lee; T. Sasaki; M. Kobayashi; O. Kikuchi; H. J. Kim; H. Yokota-Hashimoto; M. Shimpuku; V. Y. Susanti; Y. Ido-Kitamura; K. Kimura; H. Inoue; M. Tanaka-Okamoto; H. Ishizaki; J. Miyoshi; S. Ohya; Y. Tanaka; S. Kitajima; T. Kitamura, Jun. 2013, Diabetologia, 56, 6, 1383, 1393

  DOI
• グルカゴン, 北村 忠弘, 2013, 61, 6, 449, 453
• 膵β細胞機能・容量調節から病態まで 第3回 膵β細胞量の調節におけるFoxO1の役割, 北村忠弘, 2013, 2, 3, 19, 22
• ホルモンからアンチエイジングを科学する インスリンシグナルによる老化制御とアンチエイジング, 北村忠弘, 2014, 69, 5, 998, 1006
• 糖尿病治療のパラダイムシフト 膵β細胞量の調節機構, 北村忠弘, 2014, 113, 1, 113, 118
• グルカゴン測定系の確立の歴史と問題点, 北村忠弘; 小林雅樹, 2014, 38, 5, 456, 461
• [The roles of FOXO1 in various metabolic organs]., Tadahiro Kitamura; Yukari Kitamura, 2015, Seikagaku. The Journal of Japanese Biochemical Society, 87, 2, 176, 82

  DOI
• 糖尿病治療におけるグルカゴンの重要性, 北村忠弘, 2016, 100, 100, 9-15.
• アプロチニン入り採血管でのグルカゴン保存安定性, 菊池唯史; 北村忠弘; 難波光義, 2017, 61, 7, 876, 883

  DOI
• Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice., Makiko Fukaya; Yoshiaki Tamura; Yuko Chiba; Toshihiro Tanioka; Ji Mao; Yoko Inoue; Marina Yamada; Christian Waeber; Yukari Ido-Kitamura; Tadahiro Kitamura; Masao Kaneki, 06 Dec. 2013, Biochemical and biophysical research communications, 442, 1-2, 92, 8

  DOI
• Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates., Tsutomu Sasaki; Mayumi Shimpuku; Tomoya Kitazumi; Haruna Hiraga; Yuko Nakagawa; Hiroshi Shibata; Yuko Okamatsu-Ogura; Osamu Kikuchi; Hye-jin Kim; Yuki Fujita; Jun Maruyama; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Masayuki Saito; Tadahiro Kitamura, 2013, Endocrine journal, 60, 10, 1117, 29

  DOI
• The role of FOXO1 in beta-cell failure and type 2 diabetes mellitus, Tadahiro Kitamura, Oct. 2013, NATURE REVIEWS ENDOCRINOLOGY, 9, 10, 615, 623, Book review

  DOI
• A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells, Yosuke Masubuchi; Yuko Nakagawa; Jinhui Ma; Tsutomu Sasaki; Tadahiro Kitamura; Yoritsuna Yamamoto; Hitoshi Kurose; Itaru Kojima; Hiroshi Shibata, Jan. 2013, PLOS ONE, 8, 1, e54500

  DOI
• 膵β細胞の発生生物学と再生医療への応用 FoxO1による腸管内分泌細胞分化制御, 北村忠弘, 2013, 36, 3, 211, 219
• 肥満症 II.肥満の成因と病態生理 肥満と中枢性エネルギー代謝調節機構, 北村忠弘, 2013, 71, 2, 217, 223
• SGLT2阻害薬の正体を知る SGLT2阻害薬に関連したトピックス SGLT2阻害による血中グルカゴン濃度増加, 北村忠弘, 2013, 61, 10, 817, 821
• 膵島機能に関するControversy GLP-1はどのようにしてグルカゴンを抑制するのか?, 北村忠弘, 2014, 39, 2, 128, 131
• 2型糖尿病における膵β細胞機能不全のメカニズム FoxO1を介した膵β細胞の脱分化, 北村忠弘; 北村忠弘, 2014, 38, 4, 332, 338
• 膵α細胞機能障害メカニズムの解明, 北村忠弘, 2014, 28, 1-5.
• 糖尿病 A.基礎分野での進歩 1.膵β細胞の分化・脱分化による量の調節機構, 北村忠弘, 2014, 2014, 4-9.
• 糖尿病治療薬update 糖尿病治療におけるグルカゴン制御の重要性, 北村忠弘, 2015, 73, 3, 509, 516
• 進化する糖尿病治療!~話題の新薬と治療法~I.内服薬 I-4 新しい標的,グルカゴン受容体とその拮抗薬の開発, 北村忠弘, 2016, 8, 10, 28, 33
• FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression., Noriko Kodani; Jun Nakae; Masaki Kobayashi; Osamu Kikuchi; Tadahiro Kitamura; Hiroshi Itoh, 24 Jan. 2020, iScience, 23, 1, 100798, 100798

  DOI
• 糖尿病病態における栄養素負荷時のグルカゴン分泌応答の検討, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 須賀孝慶; 松居翔; 佐々木努; 北村忠弘, 2018, 肥満研究, 24, Supplement, 166
• 視床下部室傍核オキシトシンニューロンのSIRT1がショ糖嗜好性を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2018, 肥満研究, 24, Supplement, 185
• サンドイッチELISAを用いたグルカゴン再検証の必要性, 北村忠弘; 小林雅樹, 2018, 和光純薬時報, 86, 3, 2‐4
• SIRT1はショ糖摂食選択行動を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2018, 日本栄養・食糧学会大会講演要旨集, 72nd, 238
• SGLT-2阻害薬によるグルカゴン分泌調節機構, 須賀 孝慶; 菊池 司; 小林 雅樹; 松居 翔; 橋本 博美; 河野 大輔; 佐々木 努; 竹内 一翔; 串田 祥; 山田 正信; 北村 忠弘, Apr. 2018, 糖尿病, 61, Suppl.1, S, 232
• 空腹時のグルカゴン分泌変動とその生理的意義, 小林 雅樹; 菊池 司; 竹内 一翔; 串田 祥; 黒田 雅士; 阪上 浩; 林 良敬; 佐々木 努; 北村 忠弘, 2018, 日本内分泌学会雑誌, 94, 1, 377, 377
• 空腹時における血中グルカゴンの変化とその生理的意義, 小林 雅樹; 菊池 司; 竹内 一翔; 串田 祥; 黒田 雅士; 阪上 浩; 林 良敬; 佐々木 努; 北村 忠弘, Apr. 2018, 糖尿病, 61, Suppl.1, S, 200
• SIRT1はショ糖摂食選択行動を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2018, 日本農芸化学会大会講演要旨集(Web), 2018, ROMBUNNO.2A23p15 (WEB ONLY)
• サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, 須賀 孝慶; 小林 雅樹; 菊池 司; 松居 翔; 河野 大輔; 橋本 博美; 佐々木 努; 山田 正信; 北村 忠弘, 2017, 日本内分泌学会雑誌, 18th, 3, 772, 772
• SIRT1はFGF21‐NRF2‐oxytocinシグナルを介してショ糖嗜好性を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2017, 肥満研究, 23, Supplement, 164
• サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, 須賀 孝慶; 菊池 司; 小林 雅樹; 松居 翔; 河野 大輔; 橋本 博美; 佐々木 努; 山田 正信; 北村 忠弘, Apr. 2017, 糖尿病, 60, Suppl.1, S, 394
• インスリン分泌低下はなぜ起きるのか?5.グルカゴン分泌異常―その病態生理的意義, 北村忠弘; 小林雅樹, 2017, 実験医学, 35, 2, 187‐193
• 糖尿病モデルマウスの栄養刺激に対するグルカゴン分泌応答の変化, 小林雅樹; 和田恵梨; 菊池司; 竹内一翔; 串田祥; 佐々木努; 北村忠弘, 2017, 日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨, 42nd, 55
• 1型糖尿病におけるグルカゴン分泌能の検討, 北村ゆかり; 小野香奈子; 亀田晶子; 山本圭子; 斎田将文; 森杏子; 是枝泉; 村田衣里; 齊藤美喜子; 小林雅樹; 北村忠弘, 2016, 藤沢市内科医学会雑誌, 28, 20‐21
• Sirt1によるショ糖嗜好性制御機構の解明, 松居翔; 佐々木努; 橋本博美; 河野大輔; 小林雅樹; 北村忠弘, 2016, 肥満研究, 22, Supplement, 172
• 遺伝子制御の新たな主役 栄養シグナル 第3章 栄養による遺伝子制御と生命現象・臓器機能~その破綻と疾患の観点から~9.栄養素によるグルカゴン,インスリンの変動と糖尿病との関連, 北村忠弘; 小林雅樹, 2016, 実験医学, 34, 15, 2594‐2601
• インスリン抵抗性およびNASHの病態形成における脂肪細胞PDK1-FoxO1経路の意義, 細岡 哲也; 松木 核; 野村 和弘; 松居 翔; 佐々木 努; 北村 忠弘; 江口 潤; Rosen Evan D; 中江 淳; Accili Domenico; 黒田 雅士; 阪上 浩; 春日 雅人; 小川 渉, 2016, 日本内分泌学会雑誌, 92, 1, 242, 242
• Sirt1はオキシトシンを介してショ糖嗜好性を抑制する, 松居翔; 佐々木努; 橋本博美; 沼田友理; 小林雅樹; 北村忠弘, 2016, 日本農芸化学会大会講演要旨集(Web), 2016, 3G001 (WEB ONLY)
• グルカゴンの新規測定系開発および血糖変化に伴う分泌動態の解析, 小林雅樹; 三重野園理; 宮地淳; 稲垣貴之; 菊池司; 河野大輔; 河野大輔; 林良敬; 佐々木努; 北村忠弘, 2016, 日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨, 41st, 40
• 新規高特異性サンドイッチELISAを用いたSGLT‐2阻害薬による血中グルカゴン濃度への影響の検討, 須賀孝慶; 須賀孝慶; 小林雅樹; 菊池司; 松居翔; 橋本博美; 河野大輔; 佐々木努; 山田正信; 北村忠弘, 2016, 糖尿病(Web), 59, Suppl, S.275(J‐STAGE)
• 中枢神経系のSIRT1による食嗜好性制御機構の解析, 松居翔; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2015, 肥満研究, 21, Supplement, 147
• 脂肪細胞のインスリン作用障害による代謝異常およびNASH発症・進展の分子機構の解明, 細岡 哲也; 松木 核; 野村 和弘; 松居 翔; 佐々木 努; 北村 忠弘; 江口 潤; Rosen Evan D; 中江 淳; Accili Domenico; 黒田 雅士; 阪上 浩; 春日 雅人; 小川 渉, 2015, 肥満研究, 21, Supplement, 161, 161
• グルカゴンの新規開発測定系による分泌動態の検証, 小林雅樹; 井田隆徳; 菊池司; 佐々木努; 北村忠弘, 2015, 糖尿病, 58, Supplement 1, S.264
• グルカゴン革命 糖尿病の真の分子病態を追え!概論 グルカゴンが糖尿病学・医療にもたらした“革命”とは?, 北村忠弘; 小林雅樹, 2015, 実験医学, 33, 6, 872, 879
• 中枢性Sirt1による食餌嗜好性制御機構の解析, 松居翔; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2015, 日本農芸化学会大会講演要旨集(Web), 2015, 2F11A02 (WEB ONLY)
• グルカゴン再評価の必要性と糖尿病における意義, 北村忠弘; 小林雅樹; 菊池司, 2015, 糖尿病学の進歩, 49th, 66
• 中枢神経系のSIRT1による食事嗜好性制御機構の解析, 松居翔; 佐々木努; 橋本(横田)博美; 小林雅樹; 北村忠弘, 2015, 日本生化学会大会(Web), 88th, 1P1163 (WEB ONLY)
• db/dbマウスでのヒトインスリン受容体過剰発現は,肥満と耐糖能を改善する, 佐々木努; 黒子光貴; 関根佐和子; 松居翔; 菊池司; ビナヤンティ スサンティ; 小林雅樹; 田中良典; 湯浅智之; 蛯名洋介; 北村忠弘, 2014, 肥満研究, 20, Supplement, 165
• Protection Against High-Fat Diet Induced Obesity in Helz2-Deficient Male Mice Due to Enhanced Expression of Hepatic Leptin Receptof, Tetsurou Satoh; Satoshi Yoshino; Masanobu Yamada; Koshi Hashimoto; Takuya Tomaru; Akiko Katano-Toki; Shuichi Okada; Atsushi Ozawa; Sumiyasu Ishii; Kazuhiko Horiguchi; Nobuyuki Shibusawa; Tsutomu Sasaki; Tadahiro Kitamura; Masatomo Mori, Jun. 2014, ENDOCRINE REVIEWS, 35, 3, Summary international conference
• 膵外分泌・内分泌における膜融合関連分子SNAP23の機能の解明, 國井政孝; 吉村信一郎; 高橋倫子; 小林雅樹; 佐藤隆史; 川上良介; 根本知己; 河西晴郎; 北村忠弘; 佐藤健; 原田彰宏; 原田彰宏, 2014, 日本細胞生物学会大会要旨集, 66th, 149
• ビルダグリプチンによるグルカゴン分泌抑制メカニズムの解明, 菊池司; 小林雅樹; 佐々木努; 北村忠弘, 2014, 日本内分泌学会雑誌, 90, 1, 275
• POMCニューロン特異的核内滞留型FoxO1・Sirt1ダブルノックインマウスの解析, 佐々木努; スサンティ ビナヤンティ; 橋本博美; 小林雅樹; 北村忠弘, 2014, 日本内分泌学会雑誌, 90, 1, 287
• ミグリトールは消化管内のαGI作用非依存性に,褐色脂肪のカテコラミン感受性亢進とエネルギー消費亢進を引き起こして抗肥満効果を示す, 平賀春菜; 佐々木努; 菊池司; 小林雅樹; 北村忠弘, 2014, 日本内分泌学会雑誌, 90, 1, 349
• α‐グルコシダーゼ阻害薬による体重減少効果の分子機序の比較, 新福摩弓; 佐々木努; 北住知也; 橋本博美; 小林雅樹; 二神生爾; 坂本長逸; 北村忠弘, 2013, 日本臨床生理学会雑誌, 43, 5, 52
• 視床下部弓状核のSirt1は加齢に伴う体重増加を抑制する, 佐々木努; 新福摩弓; 菊池司; ビナヤンティ スサンティ; 橋本博美; 小林雅樹; 北村忠弘, 2013, 肥満研究, 19, Supplement, 143
• POMCニューロン特異的核内滞留型FoxO1・Sirt1ダブルノックインマウスの解析, ビナヤンティ スサンティ; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2013, 肥満研究, 19, Supplement, 143
• ミグリトールは褐色脂肪の活性化とエネルギー消費亢進により抗肥満効果を示す, 平賀春菜; 佐々木努; 菊池司; 小林雅樹; 北村忠弘, 2013, 肥満研究, 19, Supplement, 206
• ビルダグリプチンによるグルカゴン分泌抑制メカニズムの解明, 菊池司; 小林雅樹; 佐々木努; 北村忠弘, 2013, 糖尿病, 56, Supplement 1, S.258
• 視床下部弓状核のSirt1はエネルギーバランスを負に制御する, 佐々木努; 新福摩弓; 菊池司; SUSANTI Vina Yanti; 橋本博美; 小林雅樹; 北村忠弘, 2013, 糖尿病, 56, Supplement 1, S.364
• 視床下部弓状核のSirt1はエネルギーバランスを負に制御する, 佐々木努; 新福摩弓; 菊池司; VINA Yanti Susanti; 橋本博美; 小林雅樹; 北村忠弘, 2013, 日本内分泌学会雑誌, 89, 1, 218
• Hypothalamic Sirt1 overexpression leads to a negative energy balance, Tsutomu Sasaki; Mayumi Shimpuku; Osamu Kikuchi; Vina Yanti Susanti; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Tadahiro Kitamura, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S58, S58, Summary international conference
• 膵α細胞特異的FoxO1遺伝子改変マウスの表現型解析, 小林雅樹; 菊池司; 佐々木勉; 北村忠弘, 2013, 日本神経内分泌学会学術集会プログラム・抄録集, 40th, 147
• 膵β細胞の寿命,運命決定に関わる転写因子FoxO1, 北村忠弘; 小林雅樹, 2013, 日本生化学会大会(Web), 86th, 3S17P-5 (WEB ONLY)
• 膵β細胞からのインスリン分泌における膜融合関連分子SNAP23の機能の解明, 國井政孝; 吉村信一郎; 高橋倫子; 小林雅樹; 今泉美香; 佐藤隆史; 佐藤健; 永松信哉; 河西春郎; 北村忠弘; 原田彰宏, 2013, 日本解剖学会総会・全国学術集会講演プログラム・抄録集, 118th, 178
• Conditional Knock-in of Sirt1 in AgRP or Pomc Neurons Lead to Lean Phenotype Due to Decreased Food Intake and Increased Energy Expenditure, Tsutomu Sasaki; Mayumi Shimpuku; Osamu Kikuchi; Kosuke Amano; Tomoya Kitamzumi; Hiromi Yokota-Hashimoto; Masaki Kobayashi; Tadahiro Kitamura, Jun. 2012, DIABETES, 61, A697, A697, Summary international conference
• ミグリトールによる体重減少効果の分子メカニズム, 新福摩弓; 佐々木努; 北住知也; 橋本博美; 小林雅樹; 北村忠弘, 2012, 糖尿病, 55, Supplement 1, S.108
• POMC・AgRPニューロンでのSirt1過剰発現マウスの摂食・エネルギー消費調節機構, 佐々木努; 新福摩弓; 菊池司; 橋本博美; 小林雅樹; 北村忠弘, 2012, 糖尿病, 55, Supplement 1, S.300
• 視床下部,膵臓特異的ATF3ノックアウトマウスの解析, 李容守; 菊池司; 小林雅樹; 佐々木努; 田中裕二郎; 北嶋繁孝; 北村忠弘, 2012, 糖尿病, 55, Supplement 1, S.299
• ビルダグリプチンの膵機能に対する効果の検討, 菊池司; 小林雅樹; 佐々木努; 北村忠弘, 2012, 糖尿病, 55, Supplement 1, S.305
• 視床下部,膵臓特異的ATF3ノックアウトマウス, 李容守; 菊池司; 金恵珍; 小林雅樹; 佐々木努; 田中裕二郎; 北嶋繁孝; 北村忠弘, 2012, 日本内分泌学会雑誌, 88, 1, 253
• グルカゴン調節における転写因子FoxO1の生理機能, 小林雅樹; 菊池司; 李容守; 北村忠弘, 2012, 日本内分泌学会雑誌, 88, 1, 247
• POMC・AgRPニューロンでのSirt1過剰発現マウスの摂食・エネルギー消費調節機構, 佐々木努; 新福摩弓; 菊池司; 橋本博美; 小林雅樹; 北村忠弘, 2012, 日本内分泌学会雑誌, 88, 1, 253
• 視床下部FoxO1,Sirt1による摂食,エネルギー代謝調節, 北村忠弘; 小林雅樹; 佐々木努, 2012, 日本内科学会雑誌, 101, 288
• マウス膵α細胞における転写因子FoxO1の生理機能, 小林雅樹; 菊池司; 李容守; 佐々木努; 北村忠弘, 2012, 日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨, 37th, 53
• 視床下部,膵特異的FoxO1ノックインマウスの解析, 金恵珍; 佐々木努; 小林雅樹; 北村ゆかり; 中江淳; 北村忠弘, 2011, 肥満研究, 17, Supplement, 137
• ミグリトールによる体重減少効果の分子メカニズム, 新福摩弓; 佐々木努; 北住知也; 小林雅樹; 橋本博美; 北村ゆかり; 北村忠弘, 2011, 肥満研究, 17, Supplement, 194
• AgRP・PomcニューロンでのSirt1過剰発現マウスでの摂食・エネルギー消費調節機構, 佐々木努; 北住知也; 天野剛介; 菊池司; 橋本博美; 小林雅樹; 北村忠弘, 2011, 肥満研究, 17, Supplement, 163
• ミグリトールによる体重減少効果の分子メカニズム, 北住知也; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2011, 糖尿病, 54, Supplement 1, S.183
• 視床下部,膵特異的FoxO1ノックインマウスの解析, 金恵珍; 佐々木努; 小林雅樹; 北村ゆかり; 北村忠弘, 2011, 糖尿病, 54, Supplement 1, S.117
• POMC陽性神経細胞のSirt1はエネルギー消費を制御する, 佐々木努; 天野剛介; 北住知也; 菊池司; 小林雅樹; 北村忠弘, 2011, 糖尿病, 54, Supplement 1, S.117
• Rosa26‐Sirt1ノックインマウスを用いた視床下部Sirt1とエネルギーバランスの解析, 佐々木努; 天野剛介; 北住知也; 菊池司; 小林雅樹; 北村忠弘, 2011, 日本内分泌学会雑誌, 87, 1, 293
• 膵α細胞におけるFoxO1の機能解析, 小林雅樹; 金恵珍; 李容守; 橋本博美; 佐々木努; 北村ゆかり; 北村忠弘, 2011, 日本内分泌学会雑誌, 87, 1, 374
• Induction of Sirt1 expression in the murine hypothalamic AgRP and Pomc neurons leads to lean phenotype due to decreased food intake and increased energy expenditure, Tsutomu Sasaki; Tomoya Kitazumi; Kousuke Amano; Osamu Kikuchi; Hiromi Hashimoto; Masaki Kobayashi; Tadahiro Kitamura, 2011, NEUROSCIENCE RESEARCH, 71, E62, E62, Summary international conference

  DOI
• 転写因子FoxO1のマウス膵臓における生理機能, 小林雅樹; 菊池司; 橋本博美; 北村忠弘, 2011, 日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨, 36th, 46
• ミグリトールによる体重減少効果の分子メカニズム, 北住知也; 佐々木努; 小林雅樹; 菊池司; 天野剛介; 橋本博美; 北村ゆかり; 北村忠弘, 2010, 肥満研究, 16, Supplement, 130
• 視床下部Sirt1はAgRPを介して摂食を制御する, 佐々木努; 金惠珍; 小林雅樹; 北村ゆかり; 橋本博美; 志内哲也; 箕越靖彦; 北村忠弘, 2010, 肥満研究, 16, Supplement, 142
• 視床下部,膵臓特異的FoxO1ノックインマウスは肥満と耐糖能障害を示す, 金恵珍; 佐々木努; 小林雅樹; 北村ゆかり; 北村忠弘, 2010, 肥満研究, 16, Supplement, 130
• 膵ラ氏島内微小血管の増加とFoxO1との関連性の検討, 天野剛介; 佐々木努; 菊池司; 小林雅樹; 北住知也; 北村ゆかり; 北村忠弘, 2010, 肥満研究, 16, Supplement, 134
• Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding Via AgRP, Tsutomu Sasaki; Hye-Jin Kim; Masaki Kobayashi; Yukari-Ido Kitamura; Hiromi Yokota-Hashimoto; Tetsuya Shiuchi; Yasuhiko Minokoshi; Tadahiro Kitamura, Jun. 2010, DIABETES, 59, A665, A665, Summary international conference
• Induction of hypothalamic Sirt1 leads to cessation of feeding via AgRP, Tsutomu Sasaki; Hye-Jin Kim; Masaki Kobayashi; Yukari-Ido Kitamura; Hiromi Yokota-Hashimoto; Tetsuya Shiuchi; Yasuhiko Minokoshi; Tadahiro Kitamura, Mar. 2010, ENDOCRINE JOURNAL, 57, S353, S353, Summary international conference
• The roles of FoxO1 and Sirt1 in pancreas and hypothalamus, Tadahiro Kitamura; Tsutomu Sasaki; Masaki Kobayashi; Hye-Jin Kim; Yukari Kitamura, Mar. 2010, ENDOCRINE JOURNAL, 57, S302, S302, Summary international conference
• 膵β細胞増殖を調節するシグナル インスリンシグナル 4)FoxO1による膵β細胞量の調節, 北村忠弘; 小林雅樹; 菊池司, 2010, 月刊内分泌・糖尿病・代謝内科, 30, 1, 31, 40
• Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明, 佐々木努; 金惠珍; 小林雅樹; 北村ゆかり; 志内哲也; 箕越靖彦; 北村忠弘, 17 Sep. 2009, 肥満研究, 15, Supplement, 167
• Role of Class IA PI 3-Kinase in Pancreatic beta Cells, Kazuma Kaneko; Kohjiro Ueki; Noriko Takahashi; Tadahiro Kita-mura; Shinji Hashimoto; Motoharu Awazawa; Mitsuru Ohsugi; Ji Luo; C. Ronald Kahn; Lewis C. Cantley; Takashi Kadowaki, Jun. 2009, DIABETES, 58, A58, A58, Summary international conference
• Sirt1の視床下部における摂食行動・エネルギー代謝制御機構の解明, 佐々木努; KIM Hye‐Jin; 小林雅樹; 北村ゆかり; 志内哲也; 箕越靖彦; 北村忠弘, 2009, 糖尿病, 52, Supplement 1, S.179
• 膵特異的FoxO1トランスジェニックマウスは糖尿病を発症する, 菊池司; KIM Hye‐Jin; 小林雅樹; 佐々木努; 北村ゆかり; 北村忠弘, 2009, 糖尿病, 52, Supplement 1, S.249
• 膵特異的FoxO1ノックアウトマウスの解析, 小林雅樹; 菊池司; KIM Hye‐Jin; 佐々木努; 北村ゆかり; 北村忠弘, 2009, 糖尿病, 52, Supplement 1, S.249
• FoxO1によるChREBP調節~インスリンの肝糖利用促進作用のメカニズム~, 北村忠弘; KIM Hye‐Jin; 佐々木努; 小林雅樹; 北村ゆかり, 2009, 糖尿病, 52, Supplement 1, S.159
• 転写因子ChREBPのO‐グリコシレーションによる調節機構, 北村ゆかり; KIM Hye‐Jin; 佐々木努; 小林雅樹; 北村忠弘, 2009, 糖尿病, 52, Supplement 1, S.158
• 膵臓における転写因子FoxO1の機能解析, 小林雅樹; 菊池司; 北村忠弘, 2009, 日本内分泌学会雑誌, 85, 1, 274
• 膵細胞分化とFoxO1, 北村忠弘; 菊池司; KIM Hye‐Jin; 小林雅樹; 佐々木努; 北村ゆかり, 2009, 日本内分泌学会雑誌, 85, 1, 274
• 受容体型膜蛋白質SHPS‐1のインスリン分泌制御における機能解析, 小林雅樹; 大西浩史; 岡澤秀樹; 村田陽二; 林由里子; 小林久江; 北村忠弘; 的崎尚, 2009, 日本内分泌学会雑誌, 85, 1, 305
• The roles of FoxO1 and Sirt1 in the regulation of food intake, Tadahiro Kitamura; Tsutomu Sasaki; Yukari Kitamura, 2009, NEUROSCIENCE RESEARCH, 65, S11, S11, Summary international conference

  DOI
• 受容体型膜蛋白質SHPS‐1のインスリン分泌制御における機能解析, 小林雅樹; 大西浩史; 岡澤秀樹; 村田陽二; 林由里子; 北村忠弘; 的崎尚, 2008, 糖尿病, 51, Supplement 1, S.123
• Requirement of atypical protein kinase Cλ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes, Ko Kotani; Wataru Ogawa; Wataru Ogawa; Michihiro Matsumoto; Tadahiro Kitamura; Hiroshi Sakaue; Yasuhisa Hino; Kazuaki Miyake; Wataru Sano; Kazunori Akimoto; Shigeo Ohno; Masato Kasuga, 01 Dec. 1998, Molecular and Cellular Biology, 18, 6971, 6982
• Requirement for activation of the serine-threonine kinase Akt (Protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport, Tadahiro Kitamura; Wataru Ogawa; Wataru Ogawa; Hiroshi Sakaue; Yasuhisa Hino; Shoji Kuroda; Masafumi Takata; Michihiro Matsumoto; Tetsuo Maeda; Hiroaki Konishi; Ushio Kikkawa; Masato Kasuga, 01 Jan. 1998, Molecular and Cellular Biology, 18, 7, 3708, 3717

  DOI
• Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac, Yukari Kitamura; Tadahiro Kitamura; Hiroshi Sakaue; Tetsuo Maeda; Hikaru Ueno; Shoko Nishio; Shigeo Ohno; Shin Ichi Osada; Motoyoshi Sakaue; Wataru Ogawa; Masato Kasuga, 15 Mar. 1997, Biochemical Journal, 322, 873, 878

  DOI
• Disorder of glucagon secretion in type 2 diabetes, 北村忠弘, 2021, 医学のあゆみ, 276, 5
• グルカゴン(膵α細胞)はどこまでわかったか 9 SGLT2阻害薬とグルカゴン, 須賀孝慶; 北村忠弘, 2021, 13, 3
• グルカゴン(膵α細胞)はどこまでわかったか 5 正確なグルカゴン測定法の開発と,それを用いた2型糖尿病のグルカゴン評価, 小林雅樹; 北村忠弘, 2021, 13, 3
• 肝臓特異的グルカゴン作用不全によるPP細胞量の制御メカニズムの解明, 中川祐子; PEREYE Ofejiro; 齊藤大祐; 齊藤大祐; 深石貴大; 福中彩子; 佐藤隆史; 林良敬; 北村忠弘; 堀居拓郎; 畑田出穂; 藤谷与士夫, 2021, 97, 1
• 腹腔鏡下スリーブ状胃切除術前後での75gOGTT・クッキーテストによる耐糖能評価, 山本有香子; 戸川剛; 東長佳; 大江康光; 小座本雄軌; 小林雅樹; 北村忠弘; 柏木厚典, 2021, 41st-38th (Web)
• 膵α細胞における分岐鎖アミノ酸代謝異常は糖尿病のグルカゴン過剰分泌に関与する, 和田恵梨; 小林雅樹; 菊池司; 平野瞳子; 大日方英; 河野大輔; 北村忠弘, 2021, 97, 1
• AgRPニューロンのFTOによる体重調節機構, 河野大輔; 川端麗香; 常岡明加; 西山正彦; 佐々木努; 北村忠弘, 2021, 41st-38th (Web)
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構, 菊池司; 小林雅樹; 森田恭輔; 佐々木努; 北村忠弘, 2021, 97, 1
• グルカゴンがタンパク質嗜好性に及ぼす影響, 松居翔; 中川祐子; 藤谷与士夫; 北村忠弘; 佐々木努, 2021, 97, 1
• グルカゴン, 北村忠弘, 2021, 97, 1
• 膵α細胞からのグルカゴン分泌にPKCδが関与する, 本澤訓聖; 本澤訓聖; 藤本啓; 小林雅樹; 西村理明; 北村忠弘, 2021, 97, 1
• 視床下部のFTOによる体重調節機構, 河野大輔; 川端麗香; 常岡明加; 西山正彦; 佐々木努; 北村忠弘, 2021, 97, 1
• 腹腔鏡下スリーブ状胃切除手術による血中グルカゴンの変化~測定系による分泌応答の相違について, 小林雅樹; 山本有香子; 小座本雄軌; 関根理; 山本寛; 戸川剛; 柏木厚典; 北村忠弘, 2021, 97, 1
• グルカゴンシグナルによる膵PP細胞量の制御メカニズムの解明, 中川祐子; 林良敬; 北村忠弘; 堀居拓郎; 畑田出穂; 藤谷与士夫, 2020, 34th
• 糖尿病モデルマウスにおけるグルカゴン過分泌と分岐鎖アミノ酸摂取の関連, 和田恵梨; 小林雅樹; 河野大輔; 北村忠弘, 2020, 34th
• 糖尿病高グルカゴン血症における分岐鎖アミノ酸の関与について, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 北村忠弘, 2020, 74th
• 絶食に伴う代謝変化に対するグルカゴンの生理的役割, 小林雅樹; 菊池司; 和田恵梨; 河野大輔; 林良敬; 佐々木努; 佐々木努; 北村忠弘, 2020, 96, 1
• インスリン分泌機構とその異常 8 グルカゴン分泌異常, 北村忠弘, 2020, 12, 7
• Report of the Japan Diabetes Society’s Committee on Validation of Glucagon Assay Methods: Plasma Glucagon Levels Measured by a Novel System Correlate With the Pathology of Diabetes, 北村忠弘; 北村忠弘; 綿田裕孝; 長坂昌一郎; 石原寿光; 柴輝男; 植木浩二郎; 難波光義, 2020, 糖尿病(Web), 63, 12
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構, 菊池司; 小林雅樹; 佐々木努; 北村忠弘, 2020, 96, 1
• SGLT2とグルカゴン分泌, 北村忠弘, 2020, 50, 2
• 視床下部のFTOによるm⁶A脱メチル化を介した体重調節機構, 河野大輔; 常岡明加; 川端麗香; 西山正彦; 佐々木努; 北村忠弘, 2020, 34th
• 新規グルカゴン測定系の糖尿病臨床への応用の可能性, 北村忠弘, 2020, 54th
• サンドイッチELISAと質量分析を用いた新規グルカゴン測定法, 北村忠弘, 2019, 48, 6
• SIRT1による単純糖質嗜好性の制御を担うのは,PVNのOXTニューロンである, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2019, 2019
• 臨床医が知っておくべき糖尿病の基礎 グルカゴン研究Update~糖尿病臨床への応用を目指して~, 北村忠弘, 2019, 53rd
• グルカゴンによるアミノ酸・糖代謝調節と糖尿病・肥満, 北村忠弘; 和田恵梨; 小林雅樹, 2019, 73rd
• 糖尿病病態における分岐鎖アミノ酸負荷時のグルカゴン分泌応答機序の解明, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 北村忠弘, 2019, 13th
• 絶食時におけるグルカゴンの生理的役割, 小林雅樹; 菊池司; 和田恵梨; 河野大輔; 林良敬; 佐々木努; 北村忠弘, 2019, 13th
• グルカゴン研究Update~糖尿病の新しい診断と治療の標的を目指して~, 北村忠弘; 小林雅樹, 2019, 2019
• 糖尿病病態での分岐鎖アミノ酸によるグルカゴン過剰分泌作用の解明, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 北村忠弘, 2019, 40th-37th
• 2型糖尿病を合併した維持血液透析患者におけるグルカゴン測定法の検討, 吉澤優太; 細島康宏; 蒲澤秀門; 田邊直仁; 甲田豊; 島田久基; 高澤哲也; 伊藤孝仁; 鈴木芳樹; 宮地淳; 浜島斉; 小林雅樹; 北村忠弘; 成田一衛; 斎藤亮彦, 2019, 61, 3
• 視床下部のFTOによる体重調節機構, 河野大輔; 川端麗香; 西山正彦; 佐々木努; 北村忠弘, 2019, 40th-37th
• FGF21-Oxytocin axisは糖質嗜好性を制御する, 松居翔; 松居翔; 北村忠弘; 佐々木努; 佐々木努, 2019, 40th-37th
• 2型糖尿病を有する維持血液透析患者におけるオマリグリプチンの有用性の検討, 吉澤優太; 細島康宏; 蒲澤秀門; 田邊直仁; 甲田豊; 島田久基; 高澤哲也; 伊藤孝仁; 北村忠弘; 鈴木芳樹; 成田一衛; 斎藤亮彦, 2019, 52, Supplement 1
• プレプログルカゴン遺伝子産物による膵PP細胞の増殖制御メカニズムの解明, 中川祐子; 林良敬; 北村忠弘; 藤谷与士夫, 2019, 62, Suppl
• マウス絶食時におけるグルカゴンの生理的役割, 小林雅樹; 菊池司; 和田恵梨; 河野大輔; 林良敬; 佐々木努; 佐々木努; 北村忠弘, 2019, 44th
• 膵切除による血中グルカゴンの変化~質量分析装置による解析, 小林雅樹; 宮地淳; 中山ひとみ; 脇裕典; 三重野園理; 後藤守兄; 山下聡子; 山田研太郎; 山内敏正; 門脇孝; 北村忠弘, 2019, 62, Suppl
• グルカゴン測定法の標準化と2型糖尿病の病態把握におけるその臨床的有用性, 北村忠弘; 小林雅樹; 綿田裕孝; 佐藤博亮; 徳島眞彦; 菊池唯史; 松尾俊宏; 難波光義, 2019, 62, Suppl
• 糖尿病病態での分岐鎖アミノ酸に対するグルカゴン分泌応答障害の検証, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 須賀孝慶; 松居翔; 佐々木努; 北村忠弘, 2019, 62, Suppl
• グルカゴン研究における最近の進歩, 北村忠弘, 2019, 108, 10
• SIRT1による単純糖質嗜好性の制御を担うのは,視床下部室傍核のOxytocinニューロンである, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2019, 73rd
• 膵α細胞におけるSirt1によるグルカゴン分泌制御機構の解明, 菊池司; 小林雅樹; 森田恭輔; 佐々木努; 北村忠弘, 2019, 95, 1
• 分泌顆粒蛋白質フォグリンによる膵β細胞増殖の制御, 久保田知里; 久保田知里; 竹内利行; 小林雅樹; 北村忠弘; 鳥居征司, 2019, 66th
• グルカゴンは糖代謝よりもアミノ酸代謝に重要?~糖尿病・肥満に対する治療標的の可能性も含めて~, 北村忠弘; 和田恵梨; 小林雅樹, 2019, 12, 2
• 絶食による血中グルカゴンの変化とその生理的意義, 小林雅樹; 菊池司; 和田恵梨; 林良敬; 河野大輔; 佐々木努; 北村忠弘, 2019, 95, 1
• 糖尿病病態での分岐鎖アミノ酸によるグルカゴン分泌応答亢進機序の解明, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 須賀孝慶; 松居翔; 佐々木努; 北村忠弘, 2019, 73rd
• LC-MS/MSを用いたヒト血漿中グルカゴン定量法, 宮地淳; 小林雅樹; 三重野園理; 濱島斉; 稲垣貴之; 北村忠弘, 2019, 48
• グルカゴン研究の重要性と将来展望, 北村忠弘, 2019, 85, 3
• 視床下部室傍核オキシトシンニューロンのSIRT1が糖質嗜好性を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2019, 95, 1
• SGLT2阻害薬の可能性~これまで,そしてこれから~1 SGLT2阻害薬とグルカゴン分泌, 北村忠弘, 2019, 11, 6
• SIRT1による糖質嗜好性制御メカニズムの解明, 松居翔; 松居翔; 河野大輔; 北村忠弘; 佐々木努; 佐々木努, 2019, 42nd
• SGLT2阻害薬とDPP-4阻害薬併用の相乗・相殺効果-イプラグリフロジンによる検討-LEVELUP trial第2報, 澤野文夫; 亀井望; 宮原弥恵; 中西修平; 小武家暁子; 長野千尋; 野嶋秀樹; 前田修作; 渡邉浩; 山下真未; 岸本瑠衣; 浜岡彩; 原田佳奈; 壷井知子; 毛利慧; 森下尚明; 望月久義; 中島玲子; 蜂須賀有; 稲垣早織; 佐川純司; 北村忠弘, 2019, 62, Suppl
• グルカゴンELISA測定キットの性能評価, 菊池唯史; 北村忠弘; 難波光義, 2018, 75, 4
• 低Na血症を来した自己免疫性辺縁系脳炎症例のプロテオミクス解析, 橋本直子; 橋本直子; 河野貴史; 河野貴史; 佐々木努; 北村忠弘; 小出尚史; 小出尚史; 横手幸太郎; 横手幸太郎; 田中知明; 田中知明, 2018, 94, Suppl. Update
• 骨格筋代謝制御におけるβ2アドレナリンシグナルの役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2018, 94, 1
• New Analytical Methods for Glucagon, 北村忠弘, 2018, 糖尿病(Web), 61, 2
• 視床下部のFTOによるm⁶A修飾を介した体重調節機構, 河野大輔; 川端麗香; 佐々木努; 西山正彦; 北村忠弘, 2018, 24, Supplement
• グルカゴンは糖代謝よりもアミノ酸代謝に重要!?~糖尿病・肥満に対する治療標的の可能性も含めて~, 北村忠弘, 2018, 12th
• 消化管グルカゴン関連ペプチドと糖尿病,肥満との関連, 北村忠弘, 2018, 32
• グルカゴンと糖尿病, 北村忠弘, 2018, 52nd
• SGLT-2阻害薬によるグルカゴン分泌調節機構, 須賀孝慶; 須賀孝慶; 菊池司; 小林雅樹; 松居翔; 橋本博美; 河野大輔; 佐々木努; 竹内一翔; 串田祥; 山田正信; 北村忠弘, 2018, 61, Suppl
• 膵α細胞におけるSirt1の機能解析, 菊池司; 小林雅樹; 森田恭輔; 佐々木努; 竹内一翔; 串田祥; 北村忠弘, 2018, 61, Suppl
• What has become evident using a new glucagon measurement system, 北村忠弘; 小林雅樹, 2018, 61, Suppl
• ミグリトール添加スクロース食負荷ChREBPノックアウトマウスは新たなフルクトース不耐症のモデルである, 加藤丈博; 飯塚勝美; 鷹尾賢; 土田宏美; 堀川幸男; 北村忠弘; 武田純, 2018, 61, Suppl
• 2型糖尿病コントロール不十分例に対するDPP-4阻害薬投与群とイプラグリフロジン投与群の糖・脂質代謝改善に関する研究-第1報-, 澤野文夫; 亀井望; 宮原弥恵; 中西修平; 小武家尭子; 長野千尋; 野島秀樹; 前田修作; 渡邉浩; 山下真未; 岸本瑠衣; 浜岡彩; 森下尚明; 望月久義; 中島玲子; 原田佳奈; 蜂須賀有; 毛利慧; 稲垣早織; 壺井知子; 佐川純司; 北村忠弘, 2018, 61, Suppl
• 糖尿病病態での摂取栄養素に対するグルカゴン分泌応答異常の検証, 和田恵梨; 小林雅樹; 菊池司; 須賀孝慶; 松居翔; 河野大輔; 佐々木努; 竹内一翔; 串田祥; 北村忠弘, 2018, 61, Suppl
• 空腹時における血中グルカゴンの変化とその生理的意義, 小林雅樹; 菊池司; 竹内一翔; 串田祥; 黒田雅士; 阪上浩; 林良敬; 佐々木努; 北村忠弘, 2018, 61, Suppl
• SGLT1 in pancreatic a cells regulates glucagon secretion, possibly explaining the distinct effects of SGLT2 inhibitors, 北村忠弘; 須賀孝慶, 2018, 61, Suppl
• グルカゴンの新規測定法, 北村忠弘, 2018, 46, 2
• ChREBPノックアウトマウスはスクロース不耐症のモデルマウスである, 加藤丈博; 飯塚勝美; 鷹尾賢; 土田宏美; 堀川幸男; 北村忠弘; 武田純, 2018, 94, 1
• 絶食時における血中グルカゴンの変化とその生理的意義, 小林雅樹; 菊池司; 和田恵梨; 佐々木努; 河野大輔; 北村忠弘, 2018, 12th
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, 菊池司; 小林雅樹; 森田恭輔; 佐々木努; 竹内一翔; 串田祥; 北村忠弘, 2018, 94, 1
• SIRT1はFGF21-NRF2-oxytocinシグナルを介してショ糖嗜好性を制御する, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2018, 94, 1
• 糖尿病病態での各種栄養素に対するグルカゴン分泌動態の解明, 和田恵梨; 小林雅樹; 河野大輔; 菊池司; 須賀孝慶; 松居翔; 佐々木努; 北村忠弘, 2018, 12th
• マウス絶食時の血中グルカゴンの変化とその生理的意義, 小林雅樹; 菊池司; 和田恵梨; 佐々木努; 河野大輔; 北村忠弘, 2018, 43rd
• 分泌顆粒蛋白質フォグリンによるインスリン分泌とシグナルの連結機構, 久保田知里; 久保田知里; 齊藤直也; 河野あゆみ; 竹内利行; 小林雅樹; 北村忠弘; 穂坂正博; 五味浩司; 鳥居征司, 2018, 91st
• 臨床医が知っておくべき糖尿病の基礎 グルカゴンと糖尿病~グルカゴン研究Update~, 北村忠弘, 2017, 51st
• 胆汁酸受容体TGR5における新規パーシャルアゴニストの解析, 益子美咲; 榎本理奈; 黒沢綾; 菊池司; 北村忠弘; 武田茂樹, 2017, 14th
• 高脂肪食性摂食リズム障害におけるミクログリアのギャップ結合の役割の解明, 佐々木努; 橋本博美; 松居翔; 竹内英之; 北村忠弘, 2017, 93, 1
• グルカゴンの新規測定系開発および血糖変化に伴う分泌変動, 小林雅樹; 三重野園理; 宮地淳; 稲垣貴之; 菊池司; 河野大輔; 河野大輔; 林良敬; 佐々木努; 北村忠弘, 2017, 93, 1
• グルカゴンに作用する糖尿病薬, 北村忠弘, 2017, 6, 1
• 新しいグルカゴン測定法の糖尿病診断への応用の可能性, 北村忠弘, 2017, 32, 3
• 視床下部室傍核THニューロンの肥満発症における役割, 河野大輔; 河野大輔; 小池美帆; 北村忠弘, 2017, 23, Supplement
• 新しいグルカゴン測定法の糖尿病診断への応用の可能性, 北村忠弘, 2017, 18th
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, 菊池司; 小林雅樹; 森田恭輔; 佐々木努; 北村忠弘, 2017, 60, Suppl
• 新規開発測定系を用いた血糖変化に伴う血中グルカゴン変動の再検証, 小林雅樹; 菊池司; 稲垣貴之; 河野大輔; 河野大輔; 三重野園理; 宮地淳; 林良敬; 佐々木努; 北村忠弘, 2017, 60, Suppl
• 小腸と肝臓におけるChREBPのフルクトース代謝への関与, 加藤丈博; 飯塚勝美; 鷹尾賢; 土田宏美; 丹羽啓之; 北村忠弘; 堀川幸男; 武田純, 2017, 60, Suppl
• 耐糖能正常者を対象にクランプ法を用いて検討したグルカゴン血中濃度の変化に与える要因, 末松那都; 駒田久子; 坂口一彦; 三浦洋; 中村友昭; 岡田裕子; 廣田勇士; 小林雅樹; 北村忠弘; 稲垣貴之; 小川渉, 2017, 60, Suppl
• エネルギー代謝制御における骨格筋アドレナリンシグナルの重要性と肥満病態形成における役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2017, 3rd
• 脳SIRT1による栄養素嗜好性の制御メカニズム, 佐々木努; 松居翔; 北村忠弘, 2017, 23, Supplement
• FGF21によるオキシトシン発現制御機構の解析, 松居翔; 佐々木努; 河野大輔; 橋本博美; 小林雅樹; 北村忠弘, 2017, 93, 1
• 低Na血症を来した自己免疫性辺縁系脳炎症例のプロテオミクス解析, 橋本直子; 橋本直子; 河野貴史; 河野貴史; 佐々木努; 北村忠弘; 小出尚史; 小出尚史; 横手幸太郎; 横手幸太郎; 田中知明; 田中知明, 2017, 93, 2
• サンドイッチELISAを用いたSGLT-2阻害薬による血中グルカゴン濃度への影響の検討, 須賀孝慶; 須賀孝慶; 菊池司; 小林雅樹; 松居翔; 河野大輔; 橋本博美; 佐々木努; 山田正信; 北村忠弘, 2017, 60, Suppl
• 骨格筋アドレナリン抵抗性の代謝制御における役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2017, 60, Suppl
• 新規測定系で得られたグルカゴンの新知見, 北村忠弘; 小林雅樹; 菊池司; 須賀孝慶, 2017, 60, Suppl
• グルカゴンの病態生理的意義を基礎と臨床から考える 1.糖尿病に新たな視点を与えるグルカゴン研究の最前線, 北村忠弘, 2016, 50th
• 糖尿病の検査・診断の臨床的意義 グルカゴン測定法, 北村忠弘, 2016, 74
• 糖尿病に関する検査の進歩と課題 7 グルカゴン測定の課題, 北村忠弘, 2016, 104
• NMDA受容体コアゴニストD-セリンは食事嗜好性を制御する, 佐々木努; 松居翔; 橋本博美; 北村忠弘, 2016, 92, 1
• 糖尿病治療薬Update-適正使用に向けて 経口血糖降下薬の特性と注意点 DPP-4阻害薬, 北村忠弘, 2016, 53, 1
• グルカゴン-最新の知見-, 北村忠弘, 2016, 44, 2
• 特異的グルカゴン測定キットの開発-真のグルカゴン値の測定による病態解明-, 北村忠弘, 2016, 42, 8
• 食物の性状により引き起こされる2型糖尿病の病態解析, 伊達紫; 秋枝さやか; 北村忠弘, 2016, 92, 2
• 高脂肪食性摂食リズム障害におけるミクログリアのギャップ結合の役割の解明, 佐々木努; 橋本博美; 松居翔; 竹内英之; 北村忠弘, 2016, 22, Supplement
• 新規開発測定系を用いた血糖変化に伴うグルカゴン分泌動態の解析, 小林雅樹; 井田隆徳; 菊地司; 林良敬; 佐々木努; 北村忠弘, 2016, 59, Suppl
• ミグリトールの脂質代謝への影響に関する検討 高コレステロール食負荷マウスを用いた解析, 加藤丈博; 飯塚勝美; 呉烏徳勒胡; 土田宏美; 丹羽啓之; 堀川幸男; 北村忠弘; 武田純, 2016, 59, Suppl
• 骨格筋アドレナリン抵抗性の分子機構と肥満病態形成における役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2016, 59, Suppl
• 膵α細胞におけるSirt1によるグルカゴン分泌制御, 菊池司; 森田恭輔; 小林雅樹; 佐々木努; 北村忠弘, 2016, 59, Suppl
• マウスに対する高蛋白摂取は,負荷早期よりグルカゴン分泌異常と耐糖能異常を誘導する, 桂央士; 河盛段; 小林雅樹; 北村忠弘; 松岡孝昭; 下村伊一郎, 2016, 59, Suppl
• 多彩な症状を呈したグルカゴノーマの一例, 佐々木敦美; 本間博之; 三船俊英; 肥田親彦; 佐藤隆亮; 北村忠弘; 石田和之; 村井智美; 千田愛; 八代諭; 半谷真理; 中川理友紀; 長澤幹; 梶原隆; 武部典子; 高橋義彦; 石垣泰, 2016, 59, Suppl
• 糖・エネルギー代謝制御因子 膵β細胞・インスリン 膵β細胞の容量減少・機能不全・不活化機序 膵β細胞機能不全と脱分化, 北村忠弘, 2016, 74
• 肥満における骨格筋アドレナリン抵抗性の関与とPGC-1α新規アイソフォームの役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2016, 92, 1
• Sirt1はオキシトシンを介してショ糖嗜好性を抑制する, 松居翔; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2016, 92, 1
• グルカゴン(α細胞)研究の最前線, 北村忠弘, 2016, 92, 1
• SIRT1はFGF21-oxytocinを介してショ糖嗜好性を制御する, 佐々木努; 松居翔; 北村忠弘, 2016, 89th
• 5.膵β細胞の脱分化, 北村忠弘, 2016, 59, 5
• 膵αおよびβ細胞量制御におけるFCoRとFoxo1の生理的役割と肥満・2型糖尿病における意義, 小谷紀子; 中江淳; 川野義長; 大平理沙; 菊地徹洋; 松崎素子; 後藤伸子; 八木一騎; 北村忠弘; 伊藤裕, 2016, 22, Supplement
• 視床下部FTOによる体重調節機構, 河野大輔; 河野大輔; YANTI Susanti Vina; 小池美帆; 北村忠弘, 2016, 22, Supplement
• グルカゴン反応低下による食後低血糖を来した腎移植・膵移植後1型糖尿病の1例, 枝川幸子; 宮愛香; 山本浩平; 山本知穂; 亀田友香; 中村昭伸; 小林雅樹; 北村忠弘; 三好秀明; 渥美達也, 2016, 59, 5
• グルカゴンの新規測定系の開発と分泌動態の検証, 小林雅樹; 井田隆徳; 菊池司; 佐々木努; 北村忠弘, 2015, 91, 1
• ビルダグリプチンによるグルカゴン分泌抑制効果の検討, 菊池司; 小林雅樹; 佐々木努; 北村忠弘, 2015, 58, Supplement 1
• 新規開発高特異性サンドイッチELISA法を用いたSGLT-2阻害薬によるグルカゴン分泌への影響の検討, 須賀孝慶; 須賀孝慶; 菊池司; 小林雅樹; 森田恭輔; 松居翔; 橋本博美; 河野大輔; 佐々木努; 山田正信; 北村忠弘, 2015, 58, Supplement 1
• 見えてきたSGLT2阻害薬の実力と新たな糖尿病治療薬の可能性 新たな治療標的と創薬 グルカゴンとグルカゴン受容体, 北村忠弘; 北村忠弘, 2015, 32, 3
• 糖尿病のここがわからない!?第17回 SGLT2阻害薬の投与によってグルカゴンはなぜ上昇するのか?, 北村忠弘, 2015, 5, 2
• FTOの中枢における分布と役割, 河野大輔; VINA Yanti; 小池美帆; 北村忠弘, 2015, 21, Supplement
• これからの糖尿病治療戦略-新しい経口糖尿病薬をどう使うか-, 北村忠弘, 2015, 65
• NMDA受容体コアゴニストによる食事嗜好性調節機構, 佐々木努; 松居翔; 橋本博美; 北村忠弘, 2015, 21, Supplement
• NMDA受容体コアゴニストD-セリンは食事嗜好性を制御する, 佐々木努; 松居翔; 橋本(横田)博美; 北村忠弘, 2015, 88th
• グルカゴン測定系の課題とアプローチ, 北村忠弘, 2015, 26, 5
• 新規グルカゴン測定系を用いた糖尿病病態における血中グルカゴン値の再評価, 北村忠弘, 2015, 19
• Foxo1CoRepressor(FCoR)は,膵β細胞からα細胞への変換を抑制する, 小谷紀子; 中江淳; 川野義長; 大平理沙; 菊地徹洋; 松崎素子; 後藤伸子; 茂田文子; 八木一騎; 税所芳史; 北村忠弘; アチリ ドミニコ, 2015, 91, 1
• 骨格筋のアドレナリン抵抗性は肥満を惹起する, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2015, 21, Supplement
• 中枢性Sirt1による食餌嗜好性制御機構の解析, 松居翔; 佐々木努; 橋本博美; 小林雅樹; 北村忠弘, 2015, 91, 1
• 代謝異常症およびNASHの病態における脂肪細胞の機能不全の意義と分子機構の解明, 細岡哲也; 松木核; 野村和弘; 松居翔; 佐々木努; 北村忠弘; 江口潤; ROSEN Evan D; 中江淳; ACCILI Domenico; 春日雅人; 小川渉, 2015, 91, 1
• 肥満病態形成における骨格筋アドレナリン抵抗性の関与, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2015, 91, 1
• エイジング エイジングとホルモン(5)インスリン, 北村忠弘; 北村忠弘, 2015, 22, 2
• インスリン抵抗性・糖代謝異常の病態における脂肪細胞のPDK1-FoxO1経路の意義の解明, 細岡哲也; 松木核; 野村和弘; 松居翔; 佐々木努; 北村忠弘; 江口潤; ROSEN Evan D.; 中江淳; ACCILI Domenico; 春日雅人; 小川渉, 2015, 58, Supplement 1
• Foxo1 CoRepressor(FCoR)はメチル化を介したArx遺伝子の発現調節によりalpha細胞量を調節する, 小谷紀子; 中江淳; 川野義長; 大平理沙; 菊地徹洋; 松崎素子; 後藤伸子; 茂田文子; 八木一騎; 北村忠弘; 伊藤裕, 2015, 21, Supplement
• ミグリトールによる小腸ChREBP標的遺伝子の発現変化に関する検討, 加藤丈博; 加藤丈博; 飯塚勝美; 飯塚勝美; 呉烏徳勒胡; 土田宏美; 丹羽啓之; 堀川幸男; 北村忠弘; 武田純, 2015, 58, Supplement 1
• 肥満病態形成における骨格筋アドレナリン抵抗性の関与とPGC-1α新規アイソフォームの役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2015, 58, Supplement 1
• 脂肪細胞特異的PDK1欠損マウスを用いた代謝異常症およびNASHの病態における脂肪細胞の機能不全の意義の解明, 細岡哲也; 松木核; 野村和弘; 松居翔; 佐々木努; 北村忠弘; 江口潤; ROSEN Evan D.; 中江淳; ACCILI Domenico; 春日雅人; 小川渉, 2015, 29th
• db/dbマウスでのヒトインスリン受容体過剰発現は,肥満と耐糖能を改善する, 佐々木努; 黒子光貴; 黒子光貴; 関根佐和子; 関根佐和子; 松居翔; 菊池司; スサンティビナヤンティ; 小林雅樹; 田中良典; 湯浅智之; 蛯名洋介; 北村忠弘, 2015, 91, 1
• 糖のホメオスターシス-最近の知見 糖尿病におけるグルカゴンの意義, 北村忠弘, 2015, 13, 5
• Foxo1 CoRepressor(FCoR)は膵β細胞からα細胞への変換を抑制する, 小谷紀子; 中江淳; 大平理沙; 川野義長; 菊地徹洋; 松崎素子; 後藤伸子; 茂田文子; 八木一騎; 北村忠弘; 伊藤裕, 2015, 58, Supplement 1
• 自然突然変異により生じた新規肥満抵抗性・脂肪肝抵抗性マウスモデルの解析, 高梨幹生; 佐々木努; 野田明里; 平美乃; 高瀬暁; 岡崎佐智子; 久保田みどり; 飯塚陽子; 北村忠弘; 門脇孝; 岡崎啓明, 2014, 28th
• これからの糖尿病薬の使い分け~グルカゴンと体重に着目して~, 北村忠弘, 2014, 125th
• Testosterone(T)投与,androgen receptor(AR)欠失の肥満,ミトコンドリア産生への影響, 北田善彦; 梶田和男; 田口晧一郎; 池田貴英; 森一郎; 岡田英之; 臼井太郎; 山内雅裕; 森田浩之; 石塚達夫; 佐々木努; 北村忠弘, 2014, 57, Supplement 1
• 自然突然変異により生じた肥満抵抗性・脂肪肝抵抗性マウスの解析, 高梨幹生; 佐々木努; 野田明里; 平美乃; 高瀬暁; 岡崎佐智子; 久保田みどり; 泉田欣彦; 升田紫; 飯塚陽子; 北村忠弘; 門脇孝; 岡崎啓明, 2014, 57, Supplement 1
• 視床下部弓状核の甘味受容体による摂食調節機構, 河野大輔; 河野大輔; 河野大輔; 佐々木努; 小島至; 北村忠弘; 矢田俊彦, 2014, 20, Supplement
• グルカゴン・ルネッサンス-糖尿病治療標的の新時代, 北村忠弘, 2014, 32, 8
• 自然突然変異により生じた新規肥満抵抗性・脂肪肝抵抗性マウスの病態解明, 高梨幹生; 佐々木努; 野田明里; 池洲諒; 平美乃; 高瀬暁; 岡崎佐智子; 久保田みどり; 飯塚陽子; 北村忠弘; 門脇孝; 岡崎啓明, 2014, 46th
• 糖尿病におけるグルカゴン動態, 北村忠弘, 2014, 90, 3
• 膵β細胞のTcf7l2は糖代謝と膵β細胞量を制御する, 高木偉碩; 窪田直人; 窪田直人; 熊谷勝義; 中屋恵三; 小畑淳史; 桜井賛孝; 窪田哲也; 窪田哲也; 井上真理子; 岩本真彦; 梶原栄二; 北村忠弘; 植木浩二郎; 門脇孝, 2014, 57, Supplement 1
• 肥満・肥満症の調節,発症に関わる因子 エネルギーホメオスターシスとFoxO1,Sirt1, 北村忠弘, 2014, 72
• 骨格筋のアドレナリン抵抗性はPGC1α新規アイソフォームの誘導不全により肥満を惹起する, 野村和弘; 水崎奈央; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2014, 57, Supplement 1
• 膵β細胞において2型糖尿病疾患感受性遺伝子Tcf712が担う役割, 高本偉碩; 高本偉碩; 窪田直人; 窪田直人; 熊谷勝義; 中屋恵三; 桜井賛孝; 桜井賛孝; 小畑淳史; 岩本真彦; 岩本真彦; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2014, 90, 1
• 臓器間代謝ネットワークと糖尿病 各臓器のFOXO1と糖代謝調節, 北村忠弘, 2014, 25, 1
• 骨格筋のアドレナリン抵抗性はPGC1α新規アイソフォームの誘導不全により肥満を惹起する, 野村和弘; 水崎奈央; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2014, 90, 1
• Foxo1 CoRepressor (FCoR)は,Arx遺伝子のDNAメチル化を増強させ,α細胞量を調節する, 小谷紀子; 中江淳; 大平理沙; 川野義長; 菊地徹洋; 松崎素子; 後藤伸子; 茂田文子; 税所芳史; 北村忠弘; 伊藤裕, 2014, 57, Supplement 1
• 視床下部TRHの下垂体TSH分泌並びに発現制御機構, 中島康代; 岡村孝志; 渋沢信行; 小澤厚志; 堀口和彦; 橋本貢士; 佐藤哲郎; 佐々木努; 北村忠弘; 山田正信, 2014, 90, 1
• グルカゴン・ルネッサンス α細胞の解剖学,発生学, 北村忠弘, 2014, 25, 2
• Foxo1 CoRepressor(FCoR)は,Arx遺伝子のDNAメチル化を増強させ,α細胞量を調節する, 小谷紀子; 中江淳; 川野義長; 菊地徹洋; 松崎素子; 後藤伸子; 大平理沙; 茂田文子; 税所芳史; 北村忠弘; 伊藤裕, 2014, 90, 1
• 転写因子KLF5はAMPK,FoxO1,AgRPをつなぐ摂食調節の鍵因子である, 小島敏弥; 眞鍋一郎; 田中由美子; 佐々木努; 窪田直人; 北村忠弘; 門脇孝; 永井良三; 小室一成, 2014, 20, Supplement
• 転写因子FOXO1は骨格筋のグルタミン代謝を活性化する, 亀井康富; 服部真季; 畑澤幸乃; 金井紗綾香; 北村忠弘; 小川佳宏, 2014, 8th
• Foxo1CoRepressor(FCoR)は,Arx遺伝子のエピゲノム調節により,β細胞からα細胞への変換を抑制する, 小谷紀子; 中江淳; 大平理沙; 川野義長; 菊地徹洋; 松崎素子; 後藤伸子; 近藤文子; 北村忠弘; 伊藤裕, 2014, 37th
• 変わりつつある糖尿病治療戦略について考える, 北村忠弘, 2013, 63
• 視床下部弓状核のSirt1はエネルギーバランスを負に制御する, 佐々木努; 北村忠弘, 2013, 63, 2
• Helz2ノックアウトマウスは中枢性レプチン抵抗性を示すにもかかわらずメタボリック症候群抵抗性を示す, 吉野聡; 佐藤哲郎; 登丸琢也; 土岐明子; 渡邊琢也; 中島康代; 石井角保; 小澤厚志; 渋沢信行; 橋本貢士; 佐々木努; 北村忠弘; 山田正信; 森昌朋; 森昌朋, 2013, 89, 2
• ホルモン測定系の問題と疾患 グルカゴン, 北村忠弘, 2013, 61, 6
• 甘味受容体による視床下部弓状核ニューロンの活性調節, 河野大輔; 河野大輔; 河野大輔; 小島至; 北村忠弘; 矢田俊彦, 2013, 19, Supplement
• 肥満症と糖尿病, 北村忠弘; 佐々木努, 2013, 19, Supplement
• 膵β細胞において2型糖尿病疾患感受性遺伝子Tcf712が担う役割の解明, 高本偉碩; 高本偉碩; 窪田直人; 窪田直人; 熊谷勝義; 小畑淳史; 小畑淳史; 桜井賛孝; 桜井賛孝; 中屋恵三; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2013, 89, 1
• 転写因子KLF5はFoxO1によるAgRP活性を抑制し摂食を調節する, 小島敏弥; 真鍋一郎; 田中由美子; 佐々木努; 窪田直人; 北村忠弘; 門脇孝; 永井良三; 永井良三; 小室一成, 2013, 89, 2
• 飢餓時の骨格筋における転写因子FOXO1によるグルタミン代謝調節, 笠原知美; 亀井康富; 亀井康富; 狩野理延; 金井沙綾香; 三浦進司; 菅波孝祥; 北村忠弘; 小川佳宏; 小川佳宏, 2013, 67th
• マウス骨格筋で転写因子FOXO1はグルタミン代謝を調節する, 亀井康富; 亀井康富; 狩野理延; 笠原知美; 金井紗綾香; 三浦進司; 江崎治; 菅波孝祥; 北村忠弘; 小川佳宏, 2013, 2013
• 飢餓時の骨格筋で転写因子FOXO1はグルタミン代謝を調節する, 亀井康富; 笠原知美; 金井紗綾香; 岡淳一郎; 三浦進司; 江崎治; 菅波孝祥; 北村忠弘; 小川佳宏; 小川佳宏, 2013, 6, 2
• 膵β細胞において2型糖尿病疾患感受性遺伝子Tcf712が担う役割の解明, 高本偉碩; 窪田直人; 熊谷勝義; 小畑淳史; 桜井賛孝; 中屋恵三; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2013, 27th
• 膵β細胞において2型糖尿病疾患感受性遺伝子Tcf712が担う役割の解明, 高本偉碩; 窪田直人; 熊谷勝義; 小畑淳史; 桜井賛孝; 中屋恵三; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2013, 56, Supplement 1
• 肥満病態形成におけるPGC-1α新規アイソフォームの役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2013, 27th
• DPP-4阻害薬によるグルカゴン低下の機序, 北村忠弘, 2013, 2, 3
• 骨格筋機能と遺伝子発現調節, 亀井康富; 亀井康富; 笠原知美; 狩野理延; 金井紗綾香; 北村忠弘; 三浦進司; 江崎治; 小川佳宏, 2013, 67th
• 肥満病態形成におけるPGC-1α新規アイソフォームの役割, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2013, 89, 1
• 視床下部FoxO1,Sirt1によるエネルギー代謝制御, 北村忠弘; 佐々木努, 2013, 36th
• FOXO1は骨格筋のアミノ酸代謝を調節する, 畑澤幸乃; 亀井康富; 亀井康富; 笠原知美; 金井紗綾香; 狩野理延; 菅波孝祥; 北村忠弘; 小川佳宏; 小川佳宏; 小川佳宏, 2013, 19, Supplement
• 肥満病態形成におけるPGC-1α新規アイソフォームの役割, 野村和弘; 水崎奈央; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2013, 19, Supplement
• Foxo1 CoRepressor(FCoR)は,膵島においてArx遺伝子発現を抑制し,α細胞量を調節する, 小谷紀子; 中江淳; 川野義長; 菊池徹洋; 松崎素子; 税所芳史; 北村忠弘; 伊藤裕, 2013, 19, Supplement
• 転写因子KLF5はFoxO1によるAgRP活性を抑制し摂食を調節する, 小島敏弥; 真鍋一郎; 大石由美子; 大石由美子; 佐々努; 窪田直人; 北村忠弘; 門脇孝; 永井良三; 小室一成, 2013, 19, Supplement
• 膵β細胞においてTcf7l2が担う役割の解明, 高本偉碩; 高本偉碩; 窪田直人; 窪田直人; 小畑淳史; 小畑淳史; 桜井賛孝; 桜井賛孝; 熊谷勝義; 中屋恵三; 勝山修行; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2012, 88, 1
• アンドロゲン受容体欠損マウスの肥満は視床下部の小胞体ストレス制御破綻に起因する, 佐藤隆史; 沢津橋俊; 溝端健亮; 三宅由花; 齋田佳織; 佐々木努; 北村忠弘; 柳瀬敏彦; 森和俊; 加藤茂明; 北川浩史, 2012, 88, 1
• 2型糖尿病感受性遺伝子Tcf7l2が膵β細胞で担う役割の解明, 高本偉碩; 窪田直人; 熊谷勝義; 小畑淳史; 桜井賛孝; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2012, 55, Supplement 1
• 男性ホルモンは小胞体ストレスの制御により肥満を抑制する, 佐藤隆史; 沢津橋俊; 三宅由花; 溝端健亮; 齋田佳織; 新福摩弓; 佐々木努; 北村忠弘; 柳瀬敏彦; 森和俊; 加藤茂明; 北川浩史, 2012, 2012
• β細胞分化,増殖におけるFoxO1の役割, 北村忠弘, 2012, 88, 1
• 転写因子KLF5はAgRPを抑制し摂食を調節する, 小島敏弥; 真鍋一郎; 大石由美子; 佐々木努; 窪田直人; 北村忠弘; 門脇孝; 永井良三; 永井良三, 2012, 88, 2
• PGC1α新規スプライシングバリアントは運動時の脂肪燃焼制御を通じ脂肪量とインスリン感受性を調節する, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2012, 55, Supplement 1
• PGC1α新規スプライシングバリアントのエネルギー代謝制御における機能の検討, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 阪上浩; 春日雅人; 小川渉, 2012, 26th
• PGC1α新規スプライシングバリアントのエネルギー代謝制御における機能の検討, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 春日雅人; 小川渉, 2012, 88, 1
• 転写因子KLF5はAgRPを抑制し摂食を調節する, 小島敏弥; 眞鍋一郎; 大石由美子; 佐々木努; 窪田直人; 北村忠弘; 門脇孝; 永井良三, 2011, 17, Supplement
• 2型糖尿病における膵α細胞障害の分子メカニズムの解明-新しい作用機序の糖尿病治療薬の開発を目指して, 北村忠弘, 2011, 28
• 男性ホルモンによる肥満抑制機構の解析, 北川浩史; 佐藤隆史; 沢津橋俊; 三宅由花; 齋田佳織; 佐々木努; 北村忠弘; 森和俊; 加藤茂明, 2011, 17, Supplement
• 転写コアクチベーターPGC1αの新規アイソフォームPGC1αb/cは運動時のエネルギー消費を調節する, 野村和弘; 細岡哲也; 佐々木努; 北村忠弘; 清野進; 春日雅人; 小川渉, 2011, 17, Supplement
• 膵β細胞のTcf7l2は膵β細胞量維持に重要な役割を果たしている, 高本偉碩; 窪田直人; 小畑淳史; 熊谷勝義; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2011, 73, 3
• 2型糖尿病における膵α細胞障害の分子メカニズムの解明~新しい作用機序の糖尿病治療薬の開発を目指して~, 北村忠弘, 2011, 25
• 男性ホルモンによる代謝機能制御機構の解析, 佐藤隆史; 沢津橋俊; 佐々木努; 溝端健亮; 三宅由花; 齋田佳織; 森和俊; 北村忠弘; 加藤茂明; 北川浩史, 2011, 58th
• 小胞体ストレス制御を介した新規アンドロゲン作用メカニズムの解析, 佐藤隆史; 沢津橋俊; 佐々木努; 溝端健亮; 三宅由花; 齋田佳織; 柳瀬敏彦; 北村忠弘; 森和俊; 加藤茂明; 北川浩史, 2011, 34th
• わかりやすい分子糖尿病学 FoxO1と糖尿病, 北村忠弘, 2011, 2, 4
• エネルギー代謝調節, 北村忠弘; 北村忠弘, 2011, 17, Supplement
• 成因と病態生理 メタボリックシンドローム発症基盤としての脂肪細胞機能異常 脂肪細胞の分化・増殖にかかわる転写因子 PPARファミリー,C/EBPファミリー,FoxOファミリー, 北村忠弘; 北村ゆかり, 2011, 69
• 2型糖尿病における膵・細胞障害の分子メカニズムの解明-新しい作用機序の糖尿病治療薬の開発を目指して-, 北村忠弘, 2011, 27
• 転写因子KLF5はAgRPを抑制し摂食を調節する, 小島敏弥; 真鍋一郎; 大石由美子; 藤生克仁; 佐々木努; 窪田直人; 北村忠弘; 門脇孝; 永井良三, 2011, 87, 2
• 膵β細胞のTcf712は膵β細胞量維持に重要な役割を果たしている, 高本偉碩; 窪田直人; 中屋恵三; 熊谷勝義; 小畑淳史; 勝山修行; 窪田哲也; 北村忠弘; 植木浩二郎; 門脇孝, 2011, 54, Supplement 1
• FoxO1とエネルギー代謝, 北村忠弘, 2011, 26, 14
• ChREBPのO-グリコシレーション修飾を介した肝糖代謝制御, 北村忠弘; 北村ゆかり, 2011, 87, 1
• 機能性ディスペプシアの病態生理-胃排出能と遺伝子多型-, 新福摩弓; 新福摩弓; 二神生爾; 北村忠弘; 坂本長逸, 2011, 41, 3
• SIRT1と肥満, 北村忠弘, 2010, 16, Supplement
• 糖尿病の再生医療を目指したインスリン産生細胞の作成, 北村忠弘, 2010, 24
• 膵β細胞におけるPI3キナーゼの役割, 金子和真; 植木浩二郎; 高橋倫子; 橋本信嗣; 鈴木美穂; 粟沢元晴; 岡崎由希子; 大杉満; 北村忠弘; RONALD Kahn C.; CANTLEY Lewis C.; 門脇孝, 2010, 53, Supplement 1
• 代謝 A.基礎分野での進歩 1.FoxO1による代謝制御, 北村忠弘; 北村ゆかり, 2010, 2010
• 転写因子FoxO1と骨格筋分化, 北村忠弘, 2010, 31, 5
• インスリン抵抗性 臓器インスリン抵抗性 視床下部でのインスリン作用とその障害, 北村忠弘, 2010, 58, 5
• 膵ラ氏島内微小血管の増殖メカニズムの解明-糖尿病における代償性膵島肥大との関わりから-, 北村忠弘, 2010, 24
• The Roles of FoxO Family in Adiposcience, 北村忠弘; 北村ゆかり, 2010, Adiposcience, 7, 2
• FoxO1によるChREBP調節メカニズム~インスリンによる肝脂肪合成機構の解明~, 北村ゆかり; 北村忠弘, 2009, 85, 1
• 膵β細胞におけるClass IA PI3キナーゼの役割, 金子和真; 植木浩二郎; 高橋倫子; 粟沢元晴; 北村忠弘; 大杉満; 窪田直人; 門脇孝, 2009, 85, 1
• Notch,Wnt,FOXOによる骨格筋分化制御機構, 北村忠弘, 2009, 29, 2
• 中枢性摂食調節におけるFoxO1とSirt1の役割, 北村忠弘; 佐々木努; 箕越靖彦, 2009, 15, Supplement
• 動脈硬化進展における転写因子FoxO1の役割の解明, 北村忠弘, 2009, 36
• 膵β細胞の分化,新生におけるFoxO1の意義, 北村忠弘; 北村ゆかり, 2008, 51, Supplement 1
• FoxO1-Nif3I-ChREBP経路が膵β細胞の糖毒性を調節するメカニズム, 北村ゆかり; 北村忠弘, 2008, 51, Supplement 1
• 4.シグナル伝達系 インスリン受容体シグナリング, 北村忠弘, 2008, 59, 5
• Dicer1は成体膵の内外分泌細胞の新生・維持に重要である, 森田純代; 原朱美; 小島至; 堀居拓郎; 木村美香; 北村忠弘; 落谷孝弘; 畑田出穂, 2008
• 膵β細胞の分化,新生におけるFoxO1の意義, 北村忠弘, 2008, 51, Supplement 1
• 膵細胞の分化,新生におけるFoxO1の意義, 北村忠弘; 北村ゆかり, 2008, 84, 1
• 糖尿病代謝疾患におけるエピジェネティクスと翻訳後修飾 FOXO1とリン酸化,アセチル化,ユビキチン化, 北村忠弘; 北村ゆかり, 2008, 27, 6
• シグナル伝達研究 II:現象から因子へ 16.FoxOと膵β細胞, 北村忠弘; 北村ゆかり, 2008, 26, 15
• 膵および膵外におけるFoxOの発現調節と機能, 北村忠弘; 北村ゆかり, 2008, 26, 2
• インスリンシグナルと老化, 佐々木努; 北村忠弘, 2008, 26, 6
• 大きく変わる肥満症のとらえ方-摂食とエネルギー消費のバランス機構-中枢からのアプローチ 摂食調節におけるFoxO1の役割, 北村忠弘, 2008, 63, 10
• 転写因子FoxO1を用いたインスリン産生細胞の作成~糖尿病の再生医療を目指して~, 北村忠弘, 2008, 24
• 転写因子FoxO1の各種インスリン標的臓器における役割, 北村忠弘, 2008, 58, 3
• 新時代の糖尿病学(4)-病因・診断・治療研究の進歩-FoxO1, 北村忠弘; 北村ゆかり, 2008, 66
• 視床下部FoxO1によるレプチンのエネルギー調節, 北村忠弘, 2007, 50, Supplement 1
• 膵β細胞の分化と新生における転写因子FoxO1の役割, 北村忠弘, 2007, 83, 1
• インスリンシグナルにおける転写因子FoxO1の役割, 北村忠弘, 2007, 79, 8
• 分子糖尿病学の進歩-基礎から臨床まで-2007 1.インスリン分泌の分子機構 3 膵β細胞障害におけるFoxOの役割, 北村忠弘; 北村ゆかり, 2007, 2007
• 転写因子Fox01はNotchシグナルとクロストークすることで筋細胞の分化を調節している, 北村忠弘, 2007, 50, Supplement 1
• 摂食調節因子とメタボリックシンドローム 摂食調節と神経細胞内因子 転写因子FoxO1による摂食調節ペプチドの発現調節機構, 北村忠弘, 2007, 55, 9
• 中枢神経系とメタボリックシンドローム 5.摂食調節ペプチドの発現調節機構-FoxO1, 北村忠弘, 2007, 25, 15
• インスリン抵抗性【視床下部でのインスリン作用】, 北村忠弘, 2007, 39, 4
• 転写因子Fox01のすい発生における役割, 北村忠弘; 北村ゆかり; ACCILI Domenico, 2006, 49, Supplement 1
• 転写因子FoxO1は視床下部において摂食行動を調節している, 北村ゆかり; 北村忠弘; ACCILI Domenico, 2006, 49, Supplement 1
• The Roles of Forkhead Transcription Factor Foxo1 in Glucose Metabolism, 中江淳; 北村忠弘; 北村ゆかり; HRIBAL M L; ACCILI D, 2004, 細胞工学, 23, 2
• 脂肪細胞分化におけるforkhead transcription factor Foxo1の役割, 中江淳; 北村忠弘; 北村ゆかり; 藤枝憲二; DOMENICO A, 2003, 79, 1
• PANC-1細胞の増殖と抗アポトーシスにおけるAktの役割, よう さん; 岡林克典; 湯通堂仁大; 北村忠弘; 小川渉; 木戸良明; 春日雅人, 2001, 16, 3
• インスリンによるホスフォジエステラーゼ3B (PDE3B)活性化機構の解析, 北村忠弘; 小川渉; 北村ゆかり; 黒田祥二; 安藤美和; 吉川潮; 春日雅人, 2000, 36
• インスリンによるAkt活性化におけるPKCεの関与, 松本道宏; 日野泰久; 今井誠司; 北村忠弘; 小谷光; 小川渉; 春日雅人, 2000, 43, Supplement 1
• インスリンによるAkt活性化におけるPKCεの関与, 松本道宏; 日野泰久; 北村忠弘; 小谷光; 小川渉; 春日雅人, 2000, 11, 5
• インスリン依存性のグリコーゲン合成および4E-BP1のリン酸化におけるAkt(Protein Kinase B)の役割, 高田政文; 小川渉; 北村忠弘; 日野泰久; 黒田祥二; 小谷光; 春日雅人, 1999, 10
• インスリン作用におけるAktとatypical PKCの役割, 北村忠弘; 小川渉; 春日雅人, 1999, 9, 5
• Molecular nephrology. III. Molecular biology of kidney physiological functional regulation system 3. Intracellular information transmission system. Insulin action and PI3 kinase., 北村忠弘; 小川渉; 春日雅人, 1998, 腎と透析, 45
• Crisis of NIDDM Part1. Elucidation of origin of NIDDM 1. Molecular mechanism of insulin action., 北村忠弘; 小川渉; 春日雅人, 1998, Mebio, 15, 9
• Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck., 北村忠弘; 北村ゆかり; 米沢一仁; TOTTY N F; GOUT I; 原賢太; 坂上元祥; 小川渉; 春日雅人, 1996, 分子糖尿病学, 7
• A case report of gastric schwannoma with S-100 protein immunohistochemical staining., 井上徹; 北村忠弘; 井戸ゆかり; 小林哲夫; 大江勝; 吉栖一生; 田頭幸夫; 松野寧子; 岡田聡, 1991, 兵庫県医師会医学雑誌, 34, 2
• 骨格筋アドレナリン抵抗性の代謝制御における役割, 野村 和弘; 細岡 哲也; 佐々木 努; 北村 忠弘; 阪上 浩; 春日 雅人; 小川 渉, Apr. 2017, 糖尿病, 60, Suppl.1, S, 274
• 骨格筋アドレナリン抵抗性の代謝制御における役割, 野村 和弘; 細岡 哲也; 佐々木 努; 北村 忠弘; 阪上 浩; 春日 雅人; 小川 渉, Apr. 2017, 糖尿病, 60, Suppl.1, S, 274
• 骨格筋アドレナリン抵抗性の分子機構と肥満病態形成における役割, 野村 和弘; 細岡 哲也; 佐々木 努; 北村 忠弘; 阪上 浩; 春日 雅人; 小川 渉, Apr. 2016, 糖尿病, 59, Suppl.1, S, 462
• 転写因子KLF5はAMPK、Fox01、AgRPをつなぐ摂食調節の鍵因子である, 小島 敏弥; 眞鍋 一郎; 田中 由美子; 佐々木 努; 窪田 直人; 北村 忠弘; 門脇 孝; 永井 良三; 小室 一成, Oct. 2014, 20, Suppl., 176, 176
• PGC1α新規アイソフォームの肥満病態形成における役割, 野村 和弘; 細岡 哲也; 佐々木 努; 北村 忠弘; 阪上 浩; 春日 雅人; 小川 渉, Sep. 2012, 肥満研究, 18, Suppl., 164, 164
• Role of FoxO1 in muscle cell differentiation, 北村 忠弘, Nov. 2010, Endocrinology, diabetology & metabolism, 31, 5, 478, 485
• Role of Akt in growth and survival of PANC-1 pancreatic cancer cells, YAO Z; OKABAYASHI Y; YUTSUDO Y; KITAMURA T; OGAWA W; KASUGA M, 25 Jun. 2002, 17, 3, 256, 257

Books etc

• １月刊糖尿病Diabetes, Contributor, 2019
• 17. 月刊糖尿病Diabetes, Contributor, 2016
• 1. 内分泌•糖尿病•代謝内科, Contributor, 2019
• Diabetes Update, Contributor, 2019
• 循環器内科８５巻第３号, Contributor, 2019
• 和光純薬時報８６巻第３号, Contributor, 2018
• 糖尿病６１巻第３号, Contributor, 2018
• 代謝センシングー健康、食、美容、薬、そして脳の代謝を知るー第５章, Contributor, 2018
• 医学と薬学７５巻第４号, Contributor, 2018
• 8. 内分泌•糖尿病•代謝内科, Contributor, 2018
• BIOS, Contributor, 2017
• 糖尿病学２０１７, Contributor, 2017
• 肥満と疾患〜どこまで解明されたか〜, Contributor, 2017
• 実験医学 増刊（糖尿病）, Contributor, 2017
• 実験医学 増刊（栄養素シグナル）, Contributor, 2016
• 実験医学 別冊マウス表現型解析スタンダード, 2016
• 医療情報誌Schneller, Contributor, 2016
• Medical Science Digest, Contributor, 2016
• 糖尿病５９巻第５号, Contributor, 2016
• Diabetes Journal, Contributor, 2016
• 糖尿病治療薬クリニカルクエッション, Contributor, 2016
• 診断と治療増刊号, Contributor, 2016
• 22. Medicina, Contributor, 2016
• 23. ホルモンと臨床, Contributor, 2015
• 24. Diabetes Frontier, Contributor, 2015
• 25. ホルモンと臨床, Contributor, 2015
• HORMONE FRONTIER IN GYNECOLOGY, 2015
• 27. 高崎医学, Contributor, 2015
• 28. 生化学, 2015
• 糖尿病診療マスター, Contributor, 2015
• 30. Diabetes Strategy, Contributor, 2015
• 日常臨床のための検査値のみかた, Contributor, 2015
• 実験医学 特集号（グルカゴン革命）, Supervisor, 2015
• Mebio2, Contributor, 2015
• 日本臨床, Contributor, 2015
• 内分泌？糖尿病？代謝内科, Contributor, 2013
• MEBIO, 1999
• 内分泌糖尿病科, 1999
• 分子糖尿病学の進歩, 2003
• The Annual Review of Physiology, 2003
• Islet Growth Factors, 2006
• 分子糖尿病学の進歩, 2007
• 細胞, 2007
• Endocrine Journal, 2007
• 生化学, 2007
• 実験医学, 2007
• ホルモンと臨床, 2007
• 内分泌、糖尿病科, 2008
• 日本臨床（増刊号）, 2008
• 内分泌、糖尿病科, 2008
• 実験医学（増刊）, 2008
• 生体の科学, 2008
• 最新医学, 2008
• 内分泌、糖尿病科, 2008
• 内分泌、糖尿病科, 2010
• Annual Review 糖尿病、代謝、内分泌, 2010
• 内分泌、糖尿病科, 2010
• 内分泌、糖尿病科、代謝内科, 2010
• Endocrine Journal, 2010
• アディポサイエンス, 2010
• 日本臨床、増刊号メタボリックシンドローム, 2011
• 生体の科学, 2011
• International Review of Diabetes, 2010
• ホルモンと臨床, 2010
• 細胞, 2011
• BIO Clinica, 2011
• Diabetology International, 2012
• 糖尿病学２０１３, 2013
• 高崎医学, 2013
• Diabetes Strategy, 2013
• Diabetes Frontier, 2014
• Annual Review 糖尿病？代謝？内分泌, 2014
• Diabetes Frontier, 2014
• 最新医学, 2014
• 実験医学, 2014
• 最新肥満症学, 2014
• Islet Equality, 2013
• 内科 特集 糖尿病治療のパラダイムシフト, 2014
• The Annual Review of Physiology, ANNUAL REVIEWS, 2003
• Islet Growth Factors, Landes Bioscience Eurekah, 2006
• Endocrine Journal, The Japan Endocrine Society, 2007
• Endocrine Journal, The Japan Endocrine Society, 2010
• Diabetology International, The Japan Diabetes Society, 2012

Presentations

• SGLT1 in pancreatic  cells regulates glucagon secretion, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels, Kitamura Tadahiro, 第６１回日本糖尿病学会, 25 May 2018, 24 May 2018, 26 May 2018, Domestic conference
• What has become evident using a new glucagon measurement system, Kitamura Tadahiro, 第６１回日本糖尿病学会, 24 May 2018, 24 May 2018, 26 May 2018, English, Japan, Domestic conference
• グルカゴンは糖代謝よりもアミノ酸代謝に重要！？, 北村忠弘, 第１２回日本アミノ酸学会, 20 Oct. 2018, 20 Oct. 2018, Domestic conference
• グルカゴン研究Update〜糖尿病臨床への応用を目指して〜, 北村忠弘, 第５３回糖尿病学の進歩, 02 Mar. 2019, 01 Mar. 2019, 02 Mar. 2019, Japan, Domestic conference
• SGLT1 in pancreatic  cells regulates glucagon secretion in mice, explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels, Kitamura TADAHIRO, 2019 Daegu Symposium on Obesity & Diabetes, 29 Mar. 2019, 28 Mar. 2019, 30 Mar. 2019, English, Daegu, Korea, Republic of, International conference
• グルカゴン測定法の標準化と２型糖尿病の病態把握におけるその臨床的有用性, 北村忠弘, 第６２回日本糖尿病学会, 24 May 2019, 23 May 2019, 25 May 2019
• グルカゴン研究Update〜糖尿病の新しい診断と治療の標的を目指して〜, 北村忠弘, 生体機能と創薬シンポジウム2019, 30 Aug. 2019, 30 Aug. 2019, Japan, Domestic conference
• 英文論文を書いてEJに出そう！, 北村忠弘, 第２９回臨床内分泌代謝Update, 29 Nov. 2019, 29 Nov. 2019, 30 Nov. 2019, Japan, Domestic conference
• グルカゴン研究Update, 北村忠弘, 第５７回日本糖尿病学会関東甲信越地方会, 19 Jan. 2020, 18 Jan. 2020, 19 Jan. 2020, Domestic conference
• グルカゴンを標的とした新しい糖尿病治療薬の可能性, 北村忠弘, 第６４回日本糖尿病学会, 22 May 2021, 20 May 2021, 22 May 2021, Japan, Domestic conference
• グルカゴン, 北村忠弘, 第９４回日本内分泌学会, 23 Apr. 2021, 22 Apr. 2021, 24 Apr. 2021, Domestic conference
• α細胞（グルカゴン）研究Update, 北村忠弘, 第５８回日本糖尿病学会九州地方会, 17 Oct. 2020, 17 Oct. 2020, Japan, Domestic conference
• グルカゴン測定系と糖尿病におけるグルカゴン分泌異常, 北村忠弘, 第６３回日本糖尿病学会, Oct. 2020, 05 Oct. 2020, Japan, Domestic conference
• 新規グルカゴン測定系の糖尿病臨床への応用の可能性, 北村忠弘, 第５４回糖尿病学の進歩, 03 Sep. 2020, 02 Sep. 2020, 03 Sep. 2020, Japanese, Domestic conference
• The role of transcription factor FoxO1 in the regulation of food intake, 27th Annual Meeting of Japan Society for the Study of Obesity, 2006
• The role of transcription factor FoxO1 in the regulation of food intake, 5th Annual Metabolic Syndrome Meeting, 2006
• Cellular Signaling Mediated by Transcription Factor FoxO1, COE Program Life Science Seminar, 2006
• The role of forkhead transcription factor Foxo1 in pancreatic beta cells and brain hypothalamus, Brain Korea 21 Symposium “Gene Transcription and Human Disease”, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic beta cells and brain hypothalamus, Seminar in Chungnam National University, 2007
• Regulation of Food Intake by Foxo, Endocrinology Division Seminar Series in Columbia University, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic b cells and brain hypothalamus, Okazaki Symposium 2007 on Obesity & Diabetes, 2007
• The role of forkhead transcription factor FoxO1 in the hypothalamus, 50th Annual Meeting of the Japan Diabetes Society, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic b cells and brain hypothalamus, Symposium of Metabolic Syndrome and Cellular Signaling in Kyungpook National University Hospital, 2007
• The role of forkhead transcription factor FoxO1 in pancreatic beta cell differentiation and neogenesis ~ Aim at cell therapy for diabetes ~, 80th Annual Meeting of the Japan Endocrine Society, 2007
• The role of FoxO1 in pancreatic beta cell and brain hypothalamus, 1st Diabetes Leading-edge Conference, 2007
• The role of forkhead transcription factor FoxO1 in the central regulation of food intake, 12th Adiposcience Symposium, 2007
• Transcription factor Foxo1 controls skeletal muscle fiber type composition via interaction with Notch signaling, American Diabetes Association 67th Scientific Session, 2007
• FoxO1 controls islet cell type specification in embryonic pancreas, American Diabetes Association 65th Scientific Session, 2005
• FoxO1 antagonizes leptin regulation of AgRP and POMC through competition with STAT3, American Diabetes Association 65th Scientific Session, 2005
• Foxo1 increases hepatic insulin sensitivity via inhibition of TRB-3 a negative modulator of Akt, American Diabetes Association 65th Scientific Session, 2005
• FoxO1 acetylation controls pancreatic β？cell fate under oxidative stress, American Diabetes Association 64th Scientific Session, 2004
• The foxo-1 transcription factor mediates insulin action on muscle differentiation., American Diabetes Association 62th Scientific Session, 2002
• Lipodystrophy, growth retardation and diabetes in mice bearing hypomorphic Insulin Receptor alleles generated inducible gene knockouts, American Diabetes Association 62th Scientific Session, 2002
• Mutations of forkhead transcription factor Fkhr modulate insulin sensitivity in mice, American Diabetes Association 61th Scientific Session, 2001
• The transcription factor FKHR regulates pancreatic b cell survival., American Diabetes Association 61th Scientific Session, 2001
• Akt/PKB is required for insulin-induced phosphorylation and activation of phosphodiesterase 3B, American Diabetes Association 59th Scientific Session, 1999
• Requirement for activation of Akt in insulin stimulation of protein synthesis but not glucose transport, American Diabetes Association 58th Scientific Session, 1998
• Opposing actions of FoxO1 and Stat3 on Agrp and Pomc expression in the Hypothalamus, American Diabetes Association 64th Scientific Session, 2004
• Opposing actions of FoxO1 and Foxa2 on neurogenin3 expression through the Notch pathway, American Diabetes Association 64th Scientific Session, 2004
• FoxO1 mediates insulin action on ApoC-III and triglyceride metabolism., American Diabetes Association 64th Scientific Session, 2004
• Impaired glucose tolerance and defective insulin secretion in mice lacking type 1 IGF receptor in pancreatic beta cells, American Diabetes Association 62th Scientific Session, 2002
• Prevention of diabetes in mice lacking insulin receptors requires restoration of insulin action in liver, pancreatic beta cells and brain, American Diabetes Association 62th Scientific Session, 2002
• The roles of FoxO1 in pancreatic cell differentiation, Catholic International Stem Cell Symposium, 2009
• The roles of FoxO1 and Sirt1 in hypothalamus, Anti-aging & well-being international symposium, 2010
• 中枢性摂食調節におけるFoxO1とSirt1の役割, 第３０回日本肥満学会, 2009
• The roles of FoxO1 i pancreatic cell differentiation, 日本糖尿病学会総会, 2010
• The roles of FoxO1 and Sirt1 in pancreas and hypothalamus, Korean Society for Biochemistry and Molecular Biology, 2010
• The roles of FoxO1 in pancreas and hypothalamus, 14th International Congress of Endocrinology, 2010
• FoxO1 plays important roles in pancreatic cell differentiation and cell type specification, American Diabetes Association, 2008
• 膵b細胞の分化、新生におけるFoxO1の意義, 日本糖尿病学会総会, 2008
• 膵細胞の分化、新生におけるFoxO1の意義, 日本内分泌学会総会, 2008
• FoxO1 plays important roles in pancreatic cell differentiation and cell type specification, Asia-Pacific Diabetes and Obesity Study Group, 2008
• The roles of FoxO1 in the insulin target organ, Korean Diabetes Association, 2008
• 転写因子FoxO1の各種インスリン標的臓器における役割, 北関東医学会, 2008
• 膵b細胞の分化、新生におけるFoxO1の意義, 日本臨床分子医学会, 2008
• Pancreas specific FoxO1 transgenic and knockout mice, Nanjin Symposium on Obesity and Diabetes, 2009
• Regulation of hepatic glycolysis by FoxO1 via ChREBP O-glycosylation, American Diabetes Association, 2009
• 摂食調節機構の解明とその臨床応用, 日本内分泌学会, 2009
• 膵細胞分化とFoxO1, 日本内分泌学会, 2009
• エネルギー代謝調節, 日本肥満学会総会, 2011
• ChREBPのO-グリコシレーション修飾を介した肝糖代謝制御, 日本内分泌学会総会, 2011
• The Role for Hypothalamic Sirt1 in Control of Energy Metbolism, Korean Endocrine Society Meeting, 2011
• 視床下部FoxO1、Sirt1による摂食、エネルギー代謝調節, 日本神経消化器病学会, 2011
• 視床下部FoxO1、Sirt1による摂食、エネルギー代謝調節, 日本内科学会, 2012
• The Role of Hypothalamic Sirt1 in The Regulation of Energy Balance, International Symposium for the Study of Obesity, 2012
• The role of hypothalamic Sirt1 in the regulation of food intake and energy expenditure, 2012 Shanghai Symposium on Obesity and Diabetes, 2012
• β細胞分化、増殖におけるFoxO1の役割, 日本内分泌学会, 2012
• 視床下部Sirt1、及びATF3によるエネルギー代謝調節, 日本肥満学会, 2012
• これからの糖尿病に対する治療戦略～グルカゴンの視点から～, 第１２回内分泌学会北陸支部学術集会, 2012
• FoxO1、Sirt1と糖尿病、肥満, 抗加齢医学会, 2013
• Molecular mechanism by which DPP4 inhibitor suppresses glucagon secretion, Physiological Society of Japan, 2013
• The Role of ATF3 in The Regulation of Glucose and Energy Metabolism, Asia Pacific Obesity and Diabetes Symposium, 2013
• The mechanism by which DPP4 inhibitor lowers plasma glucagon and the role of FoxO1 in alpha cells, Japan Diabetes Society, 2013
• グルカゴンからみた糖尿病の病態認識と、それに対応した治療戦略, 第１８回アディポサイエンスシンポジウム, 2013
• 肥満症と糖尿病, 第３４回日本肥満学会, 2013
• The role of ATF3 in the regulation of glucose and energy metabolism, 12th Surugadai International Symposium, 2013
• Hypothalamic Sirt1 regulates food intake and energy expenditure, 36th Naito Conference, 2013
• 膵β細胞の寿命、運命決定に関わる転写因子FoxO1, 第８６回日本生化学会大会, 2013
• 視床下部FoxO1、Sirt1によるエネルギー代謝制御, 第３６回日本分子生物学会, 2013
• グルカゴンからみた血糖制御機構, 第４８回糖尿病学の進歩, 2014
• New specific glucagon assay revealed that plasma glucagon levels increase rather than decrease after glucose loading in mice and humans - need for re-evaluation of glucagon ？, Osaka Symposium on Obesity and Diabetes, 2014
• Newly developed glucagon sandwich ELISA revealed that plasma glucagon levels increase after glucose loading in mice and humans, 57th Japan Diabetes Association, 2014
• The role of transcription factor FoxO1 in the regulation of food intake, 27th Annual Meeting of Japan Society for the Study of Obesity, 2006
• The role of transcription factor FoxO1 in the regulation of food intake, 5th Annual Metabolic Syndrome Meeting, 2006
• Cellular Signaling Mediated by Transcription Factor FoxO1, COE Program Life Science Seminar, 2006
• The role of forkhead transcription factor Foxo1 in pancreatic beta cells and brain hypothalamus, Brain Korea 21 Symposium “Gene Transcription and Human Disease”, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic beta cells and brain hypothalamus, Seminar in Chungnam National University, 2007
• Regulation of Food Intake by Foxo, Endocrinology Division Seminar Series in Columbia University, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic b cells and brain hypothalamus, Okazaki Symposium 2007 on Obesity & Diabetes, 2007
• The role of forkhead transcription factor FoxO1 in the hypothalamus, 50th Annual Meeting of the Japan Diabetes Society, 2007
• The role of forkhead transcription factor Foxo1 in pancreatic b cells and brain hypothalamus, Symposium of Metabolic Syndrome and Cellular Signaling in Kyungpook National University Hospital, 2007
• The role of forkhead transcription factor FoxO1 in pancreatic beta cell differentiation and neogenesis ~ Aim at cell therapy for diabetes ~, 80th Annual Meeting of the Japan Endocrine Society, 2007
• The role of FoxO1 in pancreatic beta cell and brain hypothalamus, 1st Diabetes Leading-edge Conference, 2007
• The role of forkhead transcription factor FoxO1 in the central regulation of food intake, 12th Adiposcience Symposium, 2007
• Transcription factor Foxo1 controls skeletal muscle fiber type composition via interaction with Notch signaling, American Diabetes Association 67th Scientific Session, 2007
• FoxO1 controls islet cell type specification in embryonic pancreas, American Diabetes Association 65th Scientific Session, 2005
• FoxO1 antagonizes leptin regulation of AgRP and POMC through competition with STAT3, American Diabetes Association 65th Scientific Session, 2005
• Foxo1 increases hepatic insulin sensitivity via inhibition of TRB-3 a negative modulator of Akt, American Diabetes Association 65th Scientific Session, 2005
• FoxO1 acetylation controls pancreatic β？cell fate under oxidative stress, American Diabetes Association 64th Scientific Session, 2004
• Opposing actions of FoxO1 and Stat3 on Agrp and Pomc expression in the Hypothalamus, American Diabetes Association 64th Scientific Session, 2004
• Opposing actions of FoxO1 and Foxa2 on neurogenin3 expression through the Notch pathway, American Diabetes Association 64th Scientific Session, 2004
• FoxO1 mediates insulin action on ApoC-III and triglyceride metabolism., American Diabetes Association 64th Scientific Session, 2004
• Impaired glucose tolerance and defective insulin secretion in mice lacking type 1 IGF receptor in pancreatic beta cells, American Diabetes Association 62th Scientific Session, 2002
• Prevention of diabetes in mice lacking insulin receptors requires restoration of insulin action in liver, pancreatic beta cells and brain, American Diabetes Association 62th Scientific Session, 2002
• The foxo-1 transcription factor mediates insulin action on muscle differentiation., American Diabetes Association 62th Scientific Session, 2002
• Lipodystrophy, growth retardation and diabetes in mice bearing hypomorphic Insulin Receptor alleles generated inducible gene knockouts, American Diabetes Association 62th Scientific Session, 2002
• Mutations of forkhead transcription factor Fkhr modulate insulin sensitivity in mice, American Diabetes Association 61th Scientific Session, 2001
• The transcription factor FKHR regulates pancreatic b cell survival., American Diabetes Association 61th Scientific Session, 2001
• Akt/PKB is required for insulin-induced phosphorylation and activation of phosphodiesterase 3B, American Diabetes Association 59th Scientific Session, 1999
• Requirement for activation of Akt in insulin stimulation of protein synthesis but not glucose transport, American Diabetes Association 58th Scientific Session, 1998
• The roles of FoxO1 in pancreatic cell differentiation, Catholic International Stem Cell Symposium, 2009
• The roles of FoxO1 and Sirt1 in hypothalamus, Anti-aging & well-being international symposium, 2010
• The roles of FoxO1 and Sirt1 in pancreas and hypothalamus, Korean Society for Biochemistry and Molecular Biology, 2010
• The roles of FoxO1 in pancreas and hypothalamus, 14th International Congress of Endocrinology, 2010
• FoxO1 plays important roles in pancreatic cell differentiation and cell type specification, American Diabetes Association, 2008
• FoxO1 plays important roles in pancreatic cell differentiation and cell type specification, Asia-Pacific Diabetes and Obesity Study Group, 2008
• The roles of FoxO1 in the insulin target organ, Korean Diabetes Association, 2008
• Pancreas specific FoxO1 transgenic and knockout mice, Nanjin Symposium on Obesity and Diabetes, 2009
• Regulation of hepatic glycolysis by FoxO1 via ChREBP O-glycosylation, American Diabetes Association, 2009
• The Role for Hypothalamic Sirt1 in Control of Energy Metbolism, Korean Endocrine Society Meeting, 2011
• The role of hypothalamic Sirt1 in the regulation of food intake and energy expenditure, 2012 Shanghai Symposium on Obesity and Diabetes, 2012
• The Role of Hypothalamic Sirt1 in The Regulation of Energy Balance, International Symposium for the Study of Obesity, 2012
• Molecular mechanism by which DPP4 inhibitor suppresses glucagon secretion, Physiological Society of Japan, 2013
• The Role of ATF3 in The Regulation of Glucose and Energy Metabolism, Asia Pacific Obesity and Diabetes Symposium, 2013
• The mechanism by which DPP4 inhibitor lowers plasma glucagon and the role of FoxO1 in alpha cells, Japan Diabetes Society, 2013
• The role of ATF3 in the regulation of glucose and energy metabolism, 12th Surugadai International Symposium, 2013
• Hypothalamic Sirt1 regulates food intake and energy expenditure, 36th Naito Conference, 2013
• New specific glucagon assay revealed that plasma glucagon levels increase rather than decrease after glucose loading in mice and humans - need for re-evaluation of glucagon ？, Osaka Symposium on Obesity and Diabetes, 2014
• Newly developed glucagon sandwich ELISA revealed that plasma glucagon levels increase after glucose loading in mice and humans, 57th Japan Diabetes Association, 2014

Research Projects

• 2013, 2014, Principal investigator, Competitive research funding
• Establishment of the alpha cell analytical methods and the clarification of the mechanism for alpha cell dysfunction, KITAMURA Tadahiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 2011, 2012, Principal investigator, We tried to elucidate the significance of ATF3 and FoxO1 in the development of type 2 diabetes. First, there was no difference in the expression levels and subcellular localization of ATF3 and FoxO1 in the alpha cells of type 2 diabetic model mice. We next generated the pancreas-specific ATF3 knockout mice and analyzed metabolic parameters and the pancreas morphology. However, we couldn't find any significant change in blood glucose levels, glucose tolerance, plasma glucagon and plasma insulin levels in these mice. Furthermore, alpha cell and beta cell mass were comparable between knockout mice and control mice. By contrast, alpha cell specific FoxO1 knockin mice showed significantly increased blood glucose levels and impaired glucose tolerance compared to the control mice, which was accompanied with increased plasma glucagon levels. Thus, FoxO1 in alpha cell is important for the regulation of glucosemetabolism, but the contribution of ATF3 seems to be less important., Competitive research funding, 23659169

  対象リソースIRI
• 2015, 2016, Principal investigator, Competitive research funding
• 2019, 2021, Principal investigator, Competitive research funding
• 2013, 2015, Principal investigator, Competitive research funding
• 2011, 2012, Principal investigator, Competitive research funding
• The roles of FoxO1 and ATF3 in pancreatic alpha cells, KITAMURA Tadahiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, 2009, 2011, Principal investigator, It has been known that type 2 diabetes is caused by not only the dysfunction of pancreatic beta cells but also the dysfunction of alpha cells. However, it is still unclear how alpha cell dysfunction occurs. Previous studies revealed that transcription factor FoxO1 and ATF3 regulats proglucagon promoter activity. Therefore we attempted in this study to elucidate the physiological roles of FoxO1 and ATF3 in pancreatic alpha cells by generating alpha cell specific FoxO1 or ATF3 knockout mice. However, due to the low efficiency of cre expression in alpha cells, we couldn't see any metabolic phenotype in these mice. So, we next generated alpha cell specific FoxO1 knockin (a-FoxO1 KI) mice by using Rosa26 system. In this system, upon cre expression, stop cassette removed and then FoxO1 expression is induced by endogenous Rosa26 promoter. We confirmed alpha cell-specific expression of FoxO1 in these mice. Interestingly a-FoxO1 KI mice showed higher fed blood glucose levels than control mice, which was accompanied with higher plasma glucagon levels. Glucose tolerance test showed impaired glucose tolerance in these mice. We concluded that FoxO1 is a key regulator of glucagon gene expression in alpha cells and contribute to the regulation of glucose metabolism in vivo. On the other hand, with respect to ATF3, we crossed ATF3 flox mice with Pdx1-cre mice, in which cre is expressed in both pancreas and hypothalamus, and generate pancreas-and hypothalamus-specific ATF3 knockout mice (PHT-ATF3-KO). We found that PHT-ATF3-KO mice lean due to decreased food intake and increased energy expenditure, which leads to increased insulin sensitivity and better glucose tolerance. We also revealed that hypothalamic ATF3 regulates Agrp transcription via interacting with FoxO1 on the Agrp promoter. Therefore, ATF3 in the hypothalamus plays an important role in the regulation of glucose and energy metabolism. However, we couldn't see any change in plasma glucagon and plasma insulin levels. Also, there was no change in glucose responsive glucagon or insulin secretion from islets isolated from PHT-ATF3-KO mice. Furthermore, there was no difference in beta cell mass and alpha cell mass in these mice compared to the control mice. Therefore, we concluded that the physiological role of ATF3 in pancreas is not so significant., Competitive research funding, 21390276

  対象リソースIRI
• 2007, 2008, Principal investigator, Competitive research funding
• 1992, Competitive research funding
• 2006, Competitive research funding
• Molecular Mechanism of Diabetes, Grant-in-Aid for Scientific Research, 1992, Competitive research funding
• Central regulation of food intake and energy metabolism, Grants and Funding, 2006, Competitive research funding
• 01 Apr. 2019, 31 Mar. 2022, 19H03707
• Identification of novel glucagon-related peptides by using C-terminal anti-glucagon antibody, KITAMURA TADAHIRO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 01 Apr. 2015, 31 Mar. 2017, We tried to identify novel glucagon-related peptides by using affinity chromatography with C-terminal anti-glucagon antibody and mouse plasma samples. However, due to insufficient sample volume, we failed to identify such molecules. Then we are now trying to do it using mouse pancreas or intestine. We also evaluated currently commercially available immunoassays for glucagon by comparing with our newly developed LC/MS/MS system and found that Mercodia sandwich ELISA has much higher correlation with LC/MS/MS compared to conventional RIA., 15K15345

  対象リソースIRI
• Molecular mechanism of pancreatic alpha cell failure in type 2 diabetes, KITAMURA TADAHIRO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, 01 Apr. 2013, 31 Mar. 2016, Pancreatic alpha cell dysfunction as well as beta cell dysfunction is known to be important for pathophysiology of type 2 diabetes. However, its molecular mechanism has been unclear. Thus, we generated both knockout mice and knockin mice in which Sirt1, an NAD-dependent deacetylase and a cellular energy sensor, lack or overexpress specifically in alpha cells. The metabolic profiles and histological analysis revealed that Sirt1 negatively regulates alpha cell differentiation/proliferation, and positively regulates glucose-dependent glucagon secretion., 25293208

  対象リソースIRI
• The role of nuclear pore complex in the regulation of glucose and lipid metabolism, KITAMURA TADAHIRO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 01 Apr. 2013, 31 Mar. 2015, We show that carbohydrate response element binding protein (ChREBP), a glucose-regulated transcription factor, is O-glycosylated by OGT, leading to increased ChREBP levels, owing to decreased ubiquitination. Conversely, expression of O-GlcNAcase (GCA) in hepatocytes decreases ChREBP O-glycosylation, thus reducing its protein levels. FoxO1, a downstream effector of insulin signaling, has been known to regulate glucose metabolism in liver. We show here that FoxO1 overexpression inhibits ChREBP O-glycosylation in hepatocytes, thus reducing ChREBP levels. Conversely, conditional FoxO1 knockout in liver results in increased levels of O-glycosylated ChREBP, even in the fasted state. O-glycosylation is an important mechanism to regulate ChREBP function, and that FoxO1 is required for ChREBP O-glycosylation. We propose that FoxO1 is the shared signaling element linking glucose- and insulin-activated pathways to regulate hepatic glucose metabolism., 25670159

  対象リソースIRI
• 01 Apr. 2011, 31 Mar. 2013, 23126503
• The roles of Fox01 in pancreatic βcell differentiation and neogenesis, KITAMURA Tadahiro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, 2007, 2008, 19390246

  対象リソースIRI

Social Contribution

Social Contribution

• スーパーサイエンス校出前授業（渋川女子高校）, 18 Dec. 2019, Visiting lecture　(Target:　High school students)
• まちなかキャンパス, 18 Jan. 2019, Lecture　(Target:　General)

Academic Contribution

• 学術評議委員, Academic society etc, 2020