Researcher Profile and Settings

Researcher

• Name

  FUJIHARA Kazuyuki

Affiliation

• Neuropsychiatry, Lecturer

Profile and Settings

• Name

  Fujihara, Kazuyuki

Affiliation

• Gunma University, Graduate School of Medicine, Assistant Professor
• Gunma University, Assistant Professor

Affiliation

• Affiliation

  Graduate School of Medicine

Education

• Apr. 2010, Mar. 2014, Gunma University, Graduate School of Medicine
• Apr. 2001, Mar. 2007, Gunma University, Faculty of Medicine, School of Medicine

Research Experience

• Apr. 2017, 9999, Gunma University, Molecular Pharmacology and Oncology, Graduate School of Medicine, Assistant prof lv
• Apr. 2014, Mar. 2017, Gunma University, University Hospital, Neuropsychiatry, Assistant prof lv
• Apr. 2010, Mar. 2014, Gunma University, University Hospital, Neuropsychiatry
• Apr. 2009, Mar. 2010, Gunma University, University Hospital, Neuropsychiatry
• Apr. 2007, Mar. 2009, Gunma University, University Hospital, Clinical Education Center
• Gunma University

Research Activities

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Neuroscience - general

Research Interests

• Schizophrenia
• γ-aminobutyric acid
• knockout rat

Published Papers

• Behavioral Consequences of a Combination of Gad1 Haplodeficiency and Adolescent Exposure to an NMDA Receptor Antagonist in Long-Evans Rats, Kazuyuki Fujihara; Takumi Sato; Yoshiki Miyasaka; Tomoji Mashimo; Yuchio Yanagawa, 30 Mar. 2021, Frontiers in Pharmacology, 12, 646088.
• Relationship of γ-aminobutyric acid and glutamate+glutamine concentrations in the perigenual anterior cingulate cortex with performance of Cambridge Gambling Task, Kazuyuki Fujihara; Kosuke Narita; Yusuke Suzuki; Yuichi Takei; Masashi Suda; Minami Tagawa; Koichi Ujita; Yuki Sakai; Jin Narumoto; Jamie Near; Masato Fukuda, Apr. 2015, NeuroImage, 109, 102, 108, Scientific journal

  DOI
• Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes, Kazuyuki Fujihara; Hideki Miwa; Toshikazu Kakizaki; Ryosuke Kaneko; Masahiko Mikuni; Chiyoko Tanahira; Nobuaki Tamamaki; Yuchio Yanagawa, Sep. 2015, Neuropsychopharmacology, 40, 10, 2475, 2486, Scientific journal

  DOI
• Contribution of parvalbumin and somatostatin-expressing GABAergic neurons to slow oscillations and the balance in beta-gamma oscillations across cortical layers, Toshinobu Kuki; Kazuyuki Fujihara; Hideki Miwa; Nobuaki Tamamaki; Yuchio Yanagawa; Hajime Mushiake, 03 Feb. 2015, Frontiers in Neural Circuits, 9, Scientific journal

  DOI
• Associations among parenting experiences during childhood and adolescence, hypothalamus‐pituitary‐adrenal axis hypoactivity, and hippocampal gray matter volume reduction in young adults, Kosuke Narita; Kazuyuki Fujihara; Yuichi Takei; Masashi Suda; Yoshiyuki Aoyama; Toru Uehara; Takehiko Majima; Hirotaka Kosaka; Makoto Amanuma; Masato Fukuda; Masahiko Mikuni, Sep. 2012, Human Brain Mapping, 33, 9, 2211, 2223, Scientific journal

  DOI
• The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: A multtimodal-imaging study using MEG and MRS, Yuichi Takei; Kazuyuki Fujihara; Minami Tagawa; Naruhito Hironaga; Jamie Near; Masato Kasagi; Yumiko Takahashi; Tomokazu Motegi; Yusuke Suzuki; Yoshiyuki Aoyama; Noriko Sakurai; Miho Yamaguchi; Shozo Tobimatsu; Koichi Ujita; Yoshito Tsushima; Kosuke Narita; Masato Fukuda, Mar. 2016, NeuroImage, 128, 302, 315, Scientific journal

  DOI
• γ-Aminobutyric acid type A receptor binding affinity in the right inferior frontal gyrus at resting state predicts the performance of healthy elderly people in the visual sustained attention test., Kasagi M; Motegi T; Narita K; Fujihara K; Suzuki Y; Tagawa M; Ujita K; Shimada H; Fukuda M, 2018, International Psychogeriatrics, in press

  DOI
• Can We Find Any Sustained Neurofunctional Alteration in Remitted Depressive Patients with a History of Modified Electroconvulsive Therapy?, Saito R; Fujihara K; Kasagi M; Motegi T; Suzuki Y; Narita K; Ujita K; Fukuda M, 2017, Open Journal of Depression, 6, 3, 88, 99

  DOI
• P2-23. GABA predicts resting-state functional connectivity in cingulate cortex, Fujihara K; Narita K; Suzuki Y; Kasagi M; Motegi T; Takei Y; Tagawa M; Ujita K; Near J; Fukuda M, 2017, Clinical Neurophysiology, 128, 9, e174, e174

  DOI
• Genetic deletion of the 67‐kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats, Kazuyuki Fujihara; Takumi Sato; Yoshiki Miyasaka; Tomoji Mashimo; Yuchio Yanagawa, 15 Dec. 2020, FEBS Open Bio, (in press), Scientific journal

  DOI
• Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice, Shigeo Miyata; Toshikazu Kakizaki; Kazuyuki Fujihara; Hideru Obinata; Touko Hirano; Junichi Nakai; Mika Tanaka; Shigeyoshi Itohara; Masahiko Watanabe; Kenji F. Tanaka; Manabu Abe; Kenji Sakimura; Yuchio Yanagawa, Dec. 2020, Molecular Brain, (in press), Scientific journal
• CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia, Kazuyuki Fujihara; Kazuo Yamada; Yukio Ichitani; Toshikazu Kakizaki; Weiru Jiang; Shigeo Miyata; Takashi Suto; Daiki Kato; Shigeru Saito; Masahiko Watanabe; Yuki Kajita; Tomokazu Ohshiro; Hajime Mushiake; Yoshiki Miyasaka; Tomoji Mashimo; Hiroki Yasuda; Yuchio Yanagawa, Dec. 2020, Translational Psychiatry, 10, 1, Scientific journal

  DOI
• Frequency-Specific Resting Connectome in Bipolar Disorder: An MEG Study, Masakazu Sunaga; Yuichi Takei; Yutaka Kato; Minami Tagawa; Tomohiro Suto; Naruhito Hironaga; Takefumi Ohki; Yumiko Takahashi; Kazuyuki Fujihara; Noriko Sakurai; Koichi Ujita; Yoshito Tsushima; Masato Fukuda, 24 Jun. 2020, Frontiers in Psychiatry, 11, Scientific journal

  DOI
• Characterization of the signature of peripheral innate immunity in women with later-life major depressive disorder., Shigeo Miyata; Hirotaka Yamagata; Koji Matsuo; Shusaku Uchida; Kenichiro Harada; Kazuyuki Fujihara; Yuchio Yanagawa; Yoshifumi Watanabe; Masahiko Mikuni; Shin Nakagawa; Masato Fukuda, 23 Mar. 2020, Brain, behavior, and immunity

  DOI
• Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly, Tomokazu Motegi; Kosuke Narita; Kazuyuki Fujihara; Masato Kasagi; Yusuke Suzuki; Minami Tagawa; Koichi Ujita; Jamie Near; Masato Fukuda, 03 Oct. 2019, International Psychogeriatrics, 1, 9, Scientific journal

  DOI
• Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway., Miyata S; Kumagaya R; Kakizaki T; Fujihara K; Wakamatsu K; Yanagawa Y, 2019, Frontiers in behavioral neuroscience, 13, 131

  DOI
• FreeSurfer as a Platform for Associating Brain Structure with Function, Kazuyuki Fujihara; Yuichi Takei, Jul. 2018, Brain Nerve, 70, 7, 841, 848
• P1-1-7. Relationship between gray matter volume of posterior cingulate cortex and frontal activation, Kazuyuki Fujihara; Yuichi Takei; Minami Tagawa; Kosuke Narita; Koichi Ujita; Masato Fukuda, May 2018, Clinical Neurophysiology, 129, 5, e37, e37, Scientific journal

  DOI
• Association between scale-free brain dynamics and behavioral performance: Functional MRI study in resting state and emotional face recognition task., Kasagi M; Huang Z; Narita K; Shitara H; Motegi T; Suzuki Y; Fujihara K; Tanabe S; Kosaka H; Ujita K; Fukuda M; Northoff G, Nov. 2017, Behav. Neurol., 0, 0, 0, 2017: 2824615, Scientific journal
• 中高年齢うつ病患者の白血球に認められる遺伝子発現変化には性差が存在する, ;;;;;;;;;;, Mar. 2020, 140年会, 26Q
• Parvalbumin-positive neuron-specific GAD67 knockout mice exhibit schizophrenia-like phenotypes, Fujihara, Kazuyuki;Miwa, Hideki;Kakizaki, Toshikazu;Mikuni, Masahiko;Tanahira, Chiyoko;Tamamaki, Nobuaki;Yanagawa, Yuchio, 2011, NEUROSCIENCE RESEARCH, 71, E298, E298

  DOI
• 脳構造と脳機能をつなぐプラットフォームとしてのFreeSurfer, ;, Jul. 2018, 70, 7, 0841
• 後部帯状回体積と前頭葉機能の関連, ;;;;;, Oct. 2017, 45, 5, 432
• 巻き込み型の強迫症に対する入院治療　薬物・精神療法・家族介入による統合的アプローチ, ;;;;;;;, Oct. 2017, 119, 10, 801
• 脳磁図を用いた統合失調症の安静時神経ネットワークの研究, ;;;;;;;;;;, Jun. 2016, 29, 1, 120
• ワーキングメモリー課題中のオシレーション活動と神経伝達物質の関係についての検討　MEGとMRSによるマルチモダリティ研究, ;;;;;;;;;;;;;, Jun. 2016, 29, 1, 100
• 興奮-抑制バランスはワーキングメモリー課題におけるオシレーション変化を予測する　MEGとMRSを用いたマルチモーダル画像研究, ;;;;;;;;;;;;;;;, Oct. 2015, 43, 5, 415
• 前部帯状回のγ-アミノ酪酸(GABA)濃度と帯状回領域内の安静時機能的結合強度の関連, ;;;;;;;;, Oct. 2015, 43, 5, 446
• 精神・神経疾患における認知機能障害の病態・評価・治療:トランスレーショナルなアプローチ　精神疾患についての光トポグラフィー検査実用化の経験, ;;;;;;;;, Jul. 2016, 46回, 125
• 気分障害とインスリン抵抗性の病態生理学的関連性について, ;;;;, Nov. 2016, 31, 12, 1291
• 抑制性神経伝達障害に着目した統合失調症のモデル動物研究, 藤原 和之, Sep. 2021, 36, 10, 996
• Disrupted local beta band networks in schizophrenia revealed through graph analysis: A magnetoencephalography study., Tagawa Minami;Takei Yuichi;Kato Yutaka;Suto Tomohiro;Hironaga Naruhito;Ohki Takefumi;Takahashi Yumiko;Fujihara Kazuyuki;Sakurai Noriko;Ujita Koichi;Tsushima Yoshito;Fukuda Masato, Apr. 2022, Psychiatry and clinical neurosciences, 76, 7

  DOI
• Glioma facilitates the epileptic and tumor-suppressive gene expressions in the surrounding region., Komiyama Kazuki;Iijima Keiya;Kawabata-Iwakawa Reika;Fujihara Kazuyuki;Kakizaki Toshikazu;Yanagawa Yuchio;Yoshimoto Yuhei;Miyata Shigeo, Apr. 2022, Scientific reports, 12, 1

  DOI
• Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats., Jiang Weiru;Kakizaki Toshikazu;Fujihara Kazuyuki;Miyata Shigeo;Zhang Yue;Suto Takashi;Kato Daiki;Saito Shigeru;Shibasaki Koji;Ishizaki Yasuki;Isoda Koji;Yokoo Hideaki;Obinata Hideru;Hirano Touko;Miyasaka Yoshiki;Mashimo Tomoji;Yanagawa Yuchio, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, 2

  DOI

MISC

• Characterization of glutamate decarboxylase 67-kDa and 65-kDa isoforms knockout rats, Kazuyuki Fujihara, Toshikazu Kakizaki, Weiru Jiang, Shigeo Miyata, Yuchio Yanagawa, 21 May 2021, The Cell, 53, 7, 47, 51, Introduction scientific journal
• 社会で働くことをどう支援するか（1）～統合失調症の生活障害の特質とその支援, 福田正人; 鈴木雄介; 藤原和之; 須藤哲, 2009, 10, 4, 12, 18
• 気分障害とインスリン抵抗性の病態生理学的関連性について, 成田耕介; 茂木智和; 笠木真人; 鈴木雄介; 藤原和之; 福田正人, Nov. 2016, 1291, 1296
• 統合失調症, 藤原 和之, 2015, 36, 2, 26, 32, Others
• 脳磁図を用いた統合失調症の安静時神経ネットワークの研究, 田川みなみ; 武井雄一; 笠木真人; 高橋由美子; 加藤隆; 藤原和之; 茂木智和; 鈴木雄介; 櫻井敬子; 山口実穂; 福田正人, 2016, 29, 120, 121
• ワーキングメモリー課題中のオシレーション活動と神経伝達物質の関係についての検討－MEGとMRSによるマルチモダリティ研究, 武井雄一; 藤原和之; 田川みなみ; 笠木真人; 高橋由美子; 加藤隆; 茂木智和; 鈴木雄介; 櫻井敬子; 山口実穂; 廣永成人; 飛松省三; 成田耕介; 福田正人, 2016, 29, 100, 101

Presentations

• Behavioral phenotypes induced by the interaction between GAD67 haploinsuffic iency and neonatal NMDA receptor blockade, Kazuyuki Fujihara; Takumi Sato; Yoshiki Miyasaka; Tomoji Mashimo; Yuchio Yanagawa, NPBPPP2020, 21 Aug. 2020, 21 Aug. 2020, 23 Aug. 2020
• "グルタミン酸脱炭酸酵素67ヘテロ欠損とNMDA型グルタミン酸受容体遮断の組み合わせ によって生ずる行動学的表現型, 藤原和之、佐藤匠、宮坂佳樹、真下知士、柳川右千夫, 文部科学省新学術領域研究 先端モデル動物支援プラットフォーム若手技術講習会2020（オンライン）, 11 Sep. 2020, 11 Sep. 2020, 11 Sep. 2020, Domestic conference
• 精神神経疾患モデルとしてのグルタミン酸脱炭酸酵素GAD67ノックアウトラット, 藤原 和之, 文部科学省新学術領域研究 先端モデル動物支援プラットフォーム成果発表会2020, 02 Feb. 2021, 02 Feb. 2021, 02 Feb. 2021, Domestic conference

Awards

• Nov. 2011
• Nov. 2015
• Sep. 2019
• 2015

Social Contribution

Social Contribution

• 外部の看護学校での講演・教育, Apr. 2023, May 2023　(Target:　Teachers, Others)