研究者基本情報

研究者

• 氏名

  井上　裕介, イノウエ　ユウスケ

所属

• 分子科学部門, 教授

基本情報

• 研究者氏名（日本語）

  井上, 裕介

• 研究者氏名（カナ）

  イノウエ, ユウスケ

• researchmapへのデータアップロードの有無

  はい

使用外国語

• 発表に使用する外国語

  英語, 英語

• 執筆に使用する外国語

  英語, 英語

所属

• 群馬大学, 教授

所属部局等

• 所属情報

  大学院理工学府, 分子科学部門

• 職名情報

  教授

学位

• 博士（医学）

所属学協会

• 日本分子生物学会
• 肝細胞研究会
• 日本RNA学会
• American Society for Microbiology
• American Society for Biochemistry and Molecular Biology

研究活動情報

研究分野

• ライフサイエンス, 遺伝学
• ライフサイエンス, 細胞生物学
• ライフサイエンス, 分子生物学

研究キーワード

• HNF4alpha
• C/EBPalpha
• PPARalpha
• 肝臓
• ノックアウトマウス
• RNA
• 核内レセプター
• 転写因子
• 糖尿病
• 代謝

論文

• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice, Kasano-Camones CI, Takizawa T, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y, 2022年, J Biochem, 173, 5, 393, 411, 研究論文（学術雑誌）
• Histidine-rich glycoprotein suppresses the S100A8/A9-mediated organ-tropic metastasis of melanoma cells, Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma IMW, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto KI, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M., 2022年, Int J Mol Sci, 23, 18, 1030
• Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation, Rodrigoa AGH, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki S, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto K, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi, 2022年, Biochem Biophys Res Commun, 634, 83, 91
• Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression, Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, et al, 2019年, Mol Carcinogen, Mol Carcinogen., 58, 980, 995

  DOI
• Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue, Tomonobu N, Kinoshita R, Sumardika IW, Youyi C, Inoue Y, Yamauchi A, Yamamoto KI, Murata H, Sakaguchi M., 2019年, Biochem Biophys Rep, Biochem Biophys Rep, 18, 100619

  DOI
• Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion, Chen Y, Sumardika IW, Tomonobu N, Ruma IMW, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, et al, 2019年, Cancer Lett, Cancer Lett, 452, 178

  DOI
• Upregulation of mobility in pancreatic cancer cells by secreted S100A11 through activation of surrounding fibroblasts, Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, et al, 2019年, Oncology Research, Oncology Research, 27, 945, 956
• Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness, Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, et al, 2019年, Neoplasia, Neoplasia, 21, 627, 640

  DOI
• Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility, Bajkowska K, Sumardika IW, Tomonobu N, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Komalasari NLGY, Jiang F, Yamauchi A, Ruma IMW, Kasano-Camones CI, Inoue Y, Sakaguchi M, 2020年, Biochem Biophys Res Commun, Biochem Biophys Res Commun, 530, 432, 439

  DOI
• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, 2009年05月, Nature genetics, 41, 5, 553, 62, 研究論文（学術雑誌）

  DOI
• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, 2008年09月, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151, 研究論文（学術雑誌）

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,SunHee Yim,Gilles Lambert,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue, 2008年07月, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920, 研究論文（学術雑誌）

  DOI
• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4 alpha 2 gene, Y Inoue,M Miyazaki,T Tsuji,M Sakaguchi,K Fukaya,NH Huh,M Namba, 2001年11月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 8, 5, 481, 487, 研究論文（学術雑誌）
• Loss of nuclear localization of the S100C protein in immorialized human fibroblasts, M Sakaguchi,H Yamada,T Tsuji,Y Inoue,M Miyazaki,T Tanaka,M Namba, 2001年01月, RADIATION RESEARCH, 155, 1, 208, 214, 研究論文（学術雑誌）

  DOI
• Hepatocyte nuclear factor 4alpha controls iron metabolism and regulates transferrin receptor 2 in mouse liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, 2015年12月, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865, 研究論文（学術雑誌）

  DOI
• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, 2013年09月, PLOS ONE, 8, 9, e74637, 研究論文（学術雑誌）

  DOI
• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, 2013年03月, ONCOLOGY REPORTS, 29, 3, 1073, 1079, 研究論文（学術雑誌）

  DOI
• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, 2010年11月, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273, 研究論文（学術雑誌）

  DOI
• The role of hepatocyte nuclear factor 4 alpha in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, H. Safdar,Y. Inoue,G. H. van Puijvelde,P. H. Reitsma,B. J. M. van Vlijmen, 2010年12月, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841

  DOI
• Hepatocyte nuclear factor-4 alpha is essential for glucosestimulated insulin secretion by pancreatic beta-cells, A Miura,K Yamagata,M Kakei,H Hatakeyama,N Takahashi,K Fukui,T Nammo,K Yoneda,Y Inoue,FM Sladek,MA Magnuson,H Kasai,J Miyagawa,FJ Gonzalez,Shimomura\, I, 2006年02月, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257, 研究論文（学術雑誌）

  DOI
• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha, Elyhisha A. Hanniman,Gilles Lambert,Yusuke Inoue,Frank J. Gonzalez,Christopher J. Sinal, 2006年11月, JOURNAL OF LIPID RESEARCH, 47, 11, 2503, 2514, 研究論文（学術雑誌）

  DOI
• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4 alpha and peroxisome proliferator-activated receptor alpha, Mariko Shin,Insook Kim,Yusuke Inoue,Shioko Kimura,Frank J. Gonzalez, 2006年10月, MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290, 研究論文（学術雑誌）

  DOI
• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4 alpha, Y Inoue,AM Yu,SH Yim,XC Ma,KW Krausz,J Inoue,CC Xiang,MJ Brownstein,G Eggertsen,Bjorkhem\, I,FJ Gonzalez, 2006年01月, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227, 研究論文（学術雑誌）

  DOI
• Role of hepatocyte nuclear factor 4 alpha in control of blood coagulation factor gene expression, Y Inoue,LL Peters,SH Yim,J Inoue,FJ Gonzalez, 2006年04月, JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344, 研究論文（学術雑誌）

  DOI
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, 2006年01月, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57, 研究論文（学術雑誌）

  DOI
• Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 gene, H Pu,T Tsuji,A Kondo,K Fushimi,R Ohashi,Y Inoue,T Mimura,K Hamazaki,M Miyazaki,M Namba, 1997年12月, ACTA MEDICA OKAYAMA, 51, 6, 313, 319, 研究論文（学術雑誌）

  DOI
• Pyruvate alleviates toxic effects of ethanol on cells in culture, K Fukaya,M Miyazaki,H Pu,B Katayama,Y Inoue,R Ohashi,C Nakamura,M Namba, 1997年09月, ARCHIVES OF TOXICOLOGY, 71, 10, 651, 654, 研究論文（学術雑誌）

  DOI
• Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory, K Mihara,M Miyazaki,T Kondo,K Fushimi,T Tsuji,Y Inoue,K Fukaya,C Ishioka,M Namba, 1997年10月, ACTA MEDICA OKAYAMA, 51, 5, 261, 265, 研究論文（学術雑誌）

  DOI
• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, 2007年06月, HEPATOLOGY, 45, 6, 1478, 1488, 研究論文（学術雑誌）

  DOI
• 2-DIMENSIONAL ELECTROPHORETIC ANALYSIS OF DOWN-REGULATED PROTEINS IN HUMAN FIBROBLASTS IMMORTALIZED BY TREATMENT WITH EITHER 4-NITROQUINOLINE 1-OXIDE OR CO-60 GAMMA-RAYS, T KONDO,K MIHARA,Y INOUE,M IIJIMA,M NAMBA, 1995年06月, ELECTROPHORESIS, 16, 6, 1067, 1073, 研究論文（学術雑誌）

  DOI
• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha, O Barbier,H Girard,Y Inoue,H Duez,L Villeneuve,A Kamiya,JC Fruchart,C Guillemette,FJ Gonzalez,B Staels, 2005年01月, MOLECULAR PHARMACOLOGY, 67, 1, 241, 249, 研究論文（学術雑誌）

  DOI
• Maintenance of near-diploid karyotype of PA-1 human ovarian teratocarcinoma cells due to death of polyploid cells by chromosome fragmentation/pulverization, C Gao,M Miyazaki,R Ohashi,T Tsuji,Y Inoue,M Namba, 1999年09月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 4, 3, 291, 294, 研究論文（学術雑誌）
• Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma, C Gao,R Ohashi,H Pu,Y Inoue,T Tsuji,M Miyazaki,M Namba, 1999年11月, ONCOLOGY REPORTS, 6, 6, 1267, 1271, 研究論文（学術雑誌）
• Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages, C Gao,M Miyazaki,JW Li,T Tsuji,Y Inoue,M Namba, 1999年12月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 4, 6, 597, 600, 研究論文（学術雑誌）
• Enhanced activity of cyclin A-associated kinase in immortalized human fibroblasts, R Ohashi,M Miyazaki,K Fushimi,T Tsuji,Y Inoue,N Shimizu,M Namba, 1999年08月, INTERNATIONAL JOURNAL OF CANCER, 82, 5, 754, 758, 研究論文（学術雑誌）

  DOI
• Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4 alpha and C/EBP alpha, Huma Safdar,Ka Lei Cheung,Hans L. Vos,Frank J. Gonzalez,Pieter H. Reitsma,Yusuke Inoue,Bart J. M. van Vlijmen, 2012年06月, PLOS ONE, 7, 6, 研究論文（学術雑誌）

  DOI
• Solution structure and siRNA-mediated knockdown analysis of the mitochondrial disease-related protein C12orf65, Hiroyuki Kogure,Yusuke Hikawa,Mamoru Hagihara,Naoya Tochio,Seizo Koshiba,Yusuke Inoue,Peter Guentert,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, 2012年11月, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 80, 11, 2629, 2642, 研究論文（学術雑誌）

  DOI
• C/EBP alpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism, B Courselaud,C Pigeon,Y Inoue,J Inoue,FJ Gonzalez,P Leroyer,D Gilot,K Boudjema,C Guguen-Guillouzo,P Brissott,O Loreal,G Ilyin, 2002年10月, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 43, 41163, 41170, 研究論文（学術雑誌）

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• Defective ureagenesis in mice carrying a liver-specific disruption of he-datocvte nuclear factor 4 alpha (HNF4 alpha) - HNF4 alpha regulates ornithine transcarbamylase in vivo, Y Inoue,GP Hayhurst,J Inoue,M Mori,FJ Gonzalez, 2002年07月, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 28, 25257, 25265, 研究論文（学術雑誌）

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• Role of the hepatocyte nuclear factor 4 alpha in control of the pregnane X receptor during fetal liver development, A Kamiya,Y Inoue,FJ Gonzalez, 2003年06月, HEPATOLOGY, 37, 6, 1375, 1384, 研究論文（学術雑誌）

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• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, 2003年08月, GASTROENTEROLOGY, 125, 2, 544, 555, 研究論文（学術雑誌）

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• Regulation of hepatic fasting response by PPAR gamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis, J Rhee,Y Inoue,JC Yoon,P Puigserver,ML Fan,FJ Gonzalez,BM Spiegelman, 2003年04月, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017, 研究論文（学術雑誌）

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• Serine/threonine phosphorylation regulates HNF-4 alpha-dependent redox-mediated iNOS expression in hepatocytes, HT Guo,JP Wei,Y Inoue,FJ Gonzalez,PC Kuo, 2003年04月, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 284, 4, C1090, C1099, 研究論文（学術雑誌）

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• The orphan nuclear receptor HNF4 alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4, RG Tirona,W Lee,BF Leake,LB Lan,CB Cline,Lamba\, V,F Parviz,SA Duncan,Y Inoue,FJ Gonzalez,EG Schuetz,RB Kim, 2003年02月, NATURE MEDICINE, 9, 2, 220, 224, 研究論文（学術雑誌）

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• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, 2004年04月, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862, 研究論文（学術雑誌）

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• Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice, K Matsusue,O Gavrilova,G Lambert,HB Brewer,JM Ward,Y Inoue,D LeRoith,FJ Gonzalez, 2004年11月, MOLECULAR ENDOCRINOLOGY, 18, 11, 2751, 2764, 研究論文（学術雑誌）

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• Hepatocyte nuclear factors 1 alpha and 4 alpha control expression of proline oxidase in adult liver, A Kamiya,Y Inoue,T Kodama,FJ Gonzalez, 2004年12月, FEBS LETTERS, 578, 1-2, 63, 68, 研究論文（学術雑誌）

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• Hepatocyte nuclear factor 4 alpha is a central regulator of bile acid conjugation, Y Inoue,AM Yu,J Inoue,FJ Gonzalez, 2004年01月, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489, 研究論文（学術雑誌）

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• Disruption of hepatic C/EBP alpha results in impaired glucose tolerance and age-dependent hepatosteatosis, Y Inoue,J Inoue,G Lambert,SH Yim,FJ Gonzalez, 2004年10月, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748, 研究論文（学術雑誌）

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• ATP inhibition of proliferation of immortalized human fibroblasts is greater than that of normal human diploid fibroblasts, B Katayama,M Sakaguchi,JW Li,H Pu,Y Inoue,M Namba, 1998年11月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2, 5, 603, 606, 研究論文（学術雑誌）
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, 2016年12月, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

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• β-1,3-Galactosyl-O-Glycosyl-Glycoprotein β-1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility., Sumardika IW,Youyi C,Kondo E,Inoue Y,Ruma IMW,Murata H,Kinoshita R,Yamamoto KI,Tomida S,Shien K,Sato H,Yamauchi A,Futami J,Putranto EW,Hibino T,Toyooka S,Nishibori M,Sakaguchi M, 2018年04月10日, Oncology Research, Oncology research, 26, 3, 431, 444

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• Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent Mechanisms., I Made Winarsa Ruma,Rie Kinoshita,Nahoko Tomonobu,Yusuke Inoue,Eisaku Kondo,Akira Yamauchi,Hiroki Sato,I Wayan Sumardika,Youyi Chen,Ken-Ichi Yamamoto,Hitoshi Murata,Shinichi Toyooka,Masahiro Nishibori, 2018年07月23日, Cancers, Cancers, 10, 7, E239, E239

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• Ubiquitous presence of cellular proteins that specifically bind to the 3 ' terminal region of hepatitis C virus, Y Inoue,M Miyazaki,R Ohashi,T Tsuji,K Fukaya,H Kouchi,T Uemura,K Mihara,M Namba, 1998年04月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 245, 1, 198, 203, 研究論文（学術雑誌）

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• Cyclin E overexpression responsible for growth of human hepatic tumors with p21(WAF1/CIP1/SDI1), T Tsuji,M Miyazaki,K Fushimi,K Mihara,Y Inoue,R Ohashi,M Ohtsubo,K Hamazaki,S Furusako,M Namba, 1998年01月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 242, 2, 317, 321, 研究論文（学術雑誌）

  DOI
• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, Ruma IM,Putranto EW,Kondo E,Murata H,Watanabe M,Huang P,Kinoshita R,Futami J,Inoue Y,Yamauchi A,Sumardika IW,Youyi C,Yamamoto K,Nasu Y,Nishibori M,Hibino T,Sakaguchi M, 2016年08月, Clinical and Experimental Metastasis, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627, 研究論文（学術雑誌）

  DOI
• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, 2016年11月, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250, 研究論文（学術雑誌）

  DOI
• Different expression of positive and negative regulators of hepatocyte growth in growing and shrinking hepatic lobes after portal vein branch ligation in rats, T Uemura,M Miyazaki,R Hirai,H Matsumoto,T Ota,R Ohashi,N Shimizu,T Tsuji,Y Inoue,M Namba, 2000年02月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 5, 2, 173, 179, 研究論文（学術雑誌）
• Treatment of surgically induced acute liver failure with transplantation of highly differentiated immortalized human hepatocytes, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,H Noguchi,T Matsumura,T Watanabe,T Totsugawa,N Tanaka,M Namba, 2000年09月, CELL TRANSPLANTATION, 9, 5, 733, 735, 研究論文（学術雑誌）

  DOI
• Establishment of a highly differentiated immortalized human hepatocyte cell line as a source of hepatic function in the bioartificial liver, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,H Noguchi,N Tanaka,M Namba, 2000年03月, TRANSPLANTATION PROCEEDINGS, 32, 2, 237, 241, 研究論文（学術雑誌）

  DOI
• Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes, N Kobayashi,T Fujiwara,KA Westerman,Y Inoue,M Sakaguchi,H Noguchi,M Miyazaki,J Cai,N Tanaka,IJ Fox,P Leboulch, 2000年02月, SCIENCE, 287, 5456, 1258, 1262, 研究論文（学術雑誌）

  DOI
• Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro, SH Oh,M Miyazaki,H Kouchi,Y Inoue,M Sakaguchi,T Tsuji,N Shima,K Higashio,M Namba, 2000年12月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 279, 2, 500, 504, 研究論文（学術雑誌）

  DOI
• A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines, T Tsuji,M Miyazaki,M Sakaguchi,Y Inoue,M Namba, 2000年02月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 268, 1, 20, 24, 研究論文（学術雑誌）

  DOI
• Growth inhibitory effects of ATP and its derivatives on human fibroblasts immortalized with Co-60-gamma rays, JW Li,Y Inoue,M Miyazaki,H Pu,A Kondo,M Namba, 2000年01月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 5, 1, 59, 62, 研究論文（学術雑誌）
• Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of P450 2E1-related cytotoxicity, Nozaki\, I,T Tsuji,M Sakaguchi,Y Inoue,R Hirai,A Andou,M Miyazaki,N Shimizu,M Namba, 2000年10月, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 36, 9, 566, 570, 研究論文（学術雑誌）

  DOI
• Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts, M Sakaguchi,M Miyazaki,Y Inoue,T Tsuji,H Kouchi,T Tanaka,H Yamada,M Namba, 2000年06月, JOURNAL OF CELL BIOLOGY, 149, 6, 1193, 1206, 研究論文（学術雑誌）

  DOI
• Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure, N Kobayashi,M Miyazaki,K Fukaya,Y Inoue,M Sakaguchi,T Uemura,H Noguchi,A Kondo,N Tanaka,M Namba, 2000年01月, TRANSPLANTATION, 69, 2, 202, 207, 研究論文（学術雑誌）

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, 2011年01月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717, 研究論文（学術雑誌）

  DOI
• Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or Co-60 gamma rays, T Kondo,K Mihara,Y Inoue,M Namba, 1996年10月, ELECTROPHORESIS, 17, 10, 1638, 1642, 研究論文（学術雑誌）

  DOI
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Hiroto Fujita,Yusuke Inoue,Masayasu Kuwahara, 2018年01月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1, 35, 39, 研究論文（学術雑誌）

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, 2014年07月, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218, 研究論文（学術雑誌）

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, 2014年07月, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630, 研究論文（学術雑誌）

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, 2014年08月, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402, 研究論文（学術雑誌）

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Morimoto A,Kannari M,Tsuchida Y,Sasaki S,Saito C,Matsuta T,Maeda T,Akiyama M,Nakamura T,Sakaguchi M,Nameki N,Gonzalez FJ,Inoue Y, 2017年06月, Journal of Biological Chemistry, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585, 研究論文（学術雑誌）

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, 2017年11月, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137, 研究論文（学術雑誌）

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, 2017年07月, ONCOLOGY LETTERS, 14, 1, 1041, 1048, 研究論文（学術雑誌）

  DOI
• Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells, Sasaki S,Hara A,Sakaguchi M,Nangaku M,Inoue Y, 2018年11月, Biochemistry and Biophysics Reports, Biochemistry and Biophysics Reports, 17, none, 87, 92

  DOI
• Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers, Takamatsu H,Yamamoto KI,Tomonobu N,Murata H,Inoue Y,Yamauchi Y,Sumardika IW,Youyi C,Kinoshita R,Yamamura M,Fujiwara H,Mitsui Y,Araki K,Futami J,Saito K,Iioka H,Ruma IM,Putranto EW,Nishibori M,Kondo E,Yamamoto Y,Toyooka S,Sakaguchi M, 2018年11月, Oncology Research, Oncology Research, 27, 6, 713, 727, 研究論文（学術雑誌）

  DOI
• Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis, Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Winarsa Ruma IM,Yamamoto H,Soh J,Hibino T,Nishibori M,Kondo E,Toyooka S,Sakaguchi M, 2018年10月, International Journal of Cancer, International Journal of Cancer, 145, 2, 569, 575

  DOI
• Induction of hepatic metabolic functions by a novel variant of hepatocyte nuclear factor 4γ., Sasaki S,Urabe M,Maeda T,Suzuki J,Irie R,Suzuki M,Tomaru Y,Sakaguchi M,Gonzalez FJ,Inoue Y, 2018年09月, Molecular and Cellular Biology, Molecular and Cellular Biology, 38, 24, e00213-18, e00213-18

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi R,Gao C,Miyazaki M,Hamazaki K,Tsuji T,Inoue Y,Uemura T,Hirai R,Shimizu N,Namba M, 2001年, Anticancer Research, Anticancer Research, 21, 657-662.
• The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory., Mihara K,Miyazaki M,Fushimi K,Tsuji T,Inoue Y,Fukaya K,Ohashi R,Namba M, 1997年, Tissue Culture Research Communications, Tissue Culture Research Communications, 16, 173, 178

  DOI
• Immortalization of cultured human fibroblasts with the mutant p53 gene and X-rays., Namba M,Mihara K,Kondo T,Inoue Y,Tsuji T,Fushimi K,Shima T,Iijima M, 1996年, Radiation Oncology Investigations, 3, 294, 298

  DOI
• Comparison of aging and immortalization process of cells derived from brains of newborn and old rats, Abe E,Yuasa T,Kondo T,Kondo Y,Tsuji T,Inoue Y,Fushimi K,Namba M, 1996年, Tissue Culture Research Communications, Tissue Culture Research Communications, 15, 179, 185

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Ahn, Sung-Hoon;Shah, Yatrik M.;Inoue, Junko;Morimura, Keiichirou;Kim, Insook;Yim, SunHee;Lambert, Gilles;Kurotani, Reiko;Nagashima, Kunio;Gonzalez, Frank J.;Inoue, Yusuke, 2008年, INFLAMMATORY BOWEL DISEASES, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level, Tomonobu, Nahoko;Komalasari, Ni Luh Gede Yoni;Sumardika, I. Wayan;Jiang, Fan;Chen, Youyi;Yamamoto, Ken-ichi;Kinoshita, Rie;Murata, Hitoshi;Inoue, Yusuke;Sakaguchi, Masakiyo, 2020年, CHEMICO-BIOLOGICAL INTERACTIONS, CHEMICO-BIOLOGICAL INTERACTIONS, 324, none, 109085, 109085

  DOI
• Synergistic regulation of hepatic Fsp27b expression by HNF4 alpha and CREBH, Kasano-Camones, Carlos Ichiro;Takizawa, Masayuki;Iwasaki, Wakana;Sasaki, Shota;Hamada, Mume;Morimoto, Aoi;Sakaguchi, Masakiyo;Gonzalez, Frank J.;Inoue, Yusuke, 2020年, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 530, 2, 432, 439

  DOI
• exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis., Rie Kinoshita,Hiroki Sato,Akira Yamauchi,Yuta Takahashi,Yusuke Inoue,I Wayan Sumardika,Youyi Chen,Nahoko Tomonobu,Kota Araki,Kazuhiko Shien,Shuta Tomida,Hidejiro Torigoe,Kei Namba,Eisuke Kurihara,Yusu, 2019年06月15日, International journal of cancer, International journal of cancer, 144, 12, 3138, 3145

  DOI
• PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice, Kasano-Camones, Carlos Ichiro;Takizawa, Masayuki;Ohshima, Noriyasu;Saito, Chinatsu;Iwasaki, Wakana;Nakagawa, Yuko;Fujitani, Yoshio;Yoshida, Ryo;Saito, Yoshifumi;Izumi, Takashi;Terawaki, Shin-Ichi;Sakaguchi, Masakiyo;Gonzalez, Frank J.;Inoue, Yusuke, 2023年, JOURNAL OF BIOCHEMISTRY, JOURNAL OF BIOCHEMISTRY, 173, 5, 393, 411

  DOI
• LOXL1 and LOXL4 are novel target genes of the Zn²⁺-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells, Hirabayashi, Daisuke;Yamamoto, Ken-ichi;Maruyama, Akihiro;Tomonobu, Nahoko;Kinoshita, Rie;Chen, Youyi;Komalasari, Ni Luh Gede Yoni;Murata, Hitoshi;Gohara, Yuma;Jiang, Fan;Zhou, Jin;Ruma, I. Made Winarsa;Sumardika, I. Wayan;Yamauchi, Akira;Kuribayashi, Futoshi;Toyooka, Shinichi;Inoue, Yusuke;Sakaguchi, Masakiyo, 2023年, FRONTIERS IN ONCOLOGY, FRONTIERS IN ONCOLOGY, 13

  DOI
• Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2, Komalasari, Ni Luh Gede Yoni;Tomonobu, Nahoko;Kinoshita, Rie;Chen, Youyi;Sakaguchi, Yoshihiko;Gohara, Yuma;Jiang, Fan;Yamamoto, Ken-ich;Murata, Hitoshi;Ruma, I. Made Winarsa;Sumardika, I. Wayan;Zhou, Jin;Yamauchi, Akira;Kuribayashi, Futoshi;Inoue, Yusuke;Toyooka, Shinichi;Sakaguchi, Masakiyo, 2023年, FRONTIERS IN ONCOLOGY, FRONTIERS IN ONCOLOGY, 13

  DOI

MISC

• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, 2009年05月, Nature genetics, 41, 5, 553, 62

  DOI
• The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line., Harukazu Suzuki,Alistair R R Forrest,Erik van Nimwegen,Carsten O Daub,Piotr J Balwierz,Katharine M Irvine,Timo Lassmann,Timothy Ravasi,Yuki Hasegawa,Michiel J L de Hoon,Shintaro Katayama,Kate Schroder,Piero Carninci,Yasuhiro Tomaru,Mutsumi Kanamori-Katayama,Atsutaka Kubosaki,Altuna Akalin,Yoshinari Ando,Erik Arner,Maki Asada,Hiroshi Asahara,Timothy Bailey,Vladimir B Bajic,Denis Bauer,Anthony G Beckhouse,Nicolas Bertin,Johan Björkegren,Frank Brombacher,Erika Bulger,Alistair M Chalk,Joe Chiba,Nicole Cloonan,Adam Dawe,Josee Dostie,Pär G Engström,Magbubah Essack,Geoffrey J Faulkner,J Lynn Fink,David Fredman,Ko Fujimori,Masaaki Furuno,Takashi Gojobori,Julian Gough,Sean M Grimmond,Mika Gustafsson,Megumi Hashimoto,Takehiro Hashimoto,Mariko Hatakeyama,Susanne Heinzel,Winston Hide,Oliver Hofmann,Michael Hörnquist,Lukasz Huminiecki,Kazuho Ikeo,Naoko Imamoto,Satoshi Inoue,Yusuke Inoue,Ryoko Ishihara,Takao Iwayanagi,Anders Jacobsen,Mandeep Kaur,Hideya Kawaji,Markus C Kerr,Ryuichiro Kimura,Syuhei Kimura,Yasumasa Kimura,Hiroaki Kitano,Hisashi Koga,Toshio Kojima,Shinji Kondo,Takeshi Konno,Anders Krogh,Adele Kruger,Ajit Kumar,Boris Lenhard,Andreas Lennartsson,Morten Lindow,Marina Lizio,Cameron Macpherson,Norihiro Maeda,Christopher A Maher,Monique Maqungo,Jessica Mar,Nicholas A Matigian,Hideo Matsuda,John S Mattick,Stuart Meier,Sei Miyamoto,Etsuko Miyamoto-Sato,Kazuhiko Nakabayashi,Yutaka Nakachi,Mika Nakano,Sanne Nygaard,Toshitsugu Okayama,Yasushi Okazaki,Haruka Okuda-Yabukami,Valerio Orlando,Jun Otomo,Mikhail Pachkov,Nikolai Petrovsky,Charles Plessy,John Quackenbush,Aleksandar Radovanovic,Michael Rehli,Rintaro Saito,Albin Sandelin,Sebastian Schmeier,Christian Schönbach,Ariel S Schwartz,Colin A Semple,Miho Sera,Jessica Severin,Katsuhiko Shirahige,Cas Simons,George St Laurent,Masanori Suzuki,Takahiro Suzuki,Matthew J Sweet,Ryan J Taft,Shizu Takeda,Yoichi Takenaka,Kai Tan,Martin S Taylor,Rohan D Teasdale,Jesper Tegnér,Sarah Teichmann,Eivind Valen,Claes Wahlestedt,Kazunori Waki,Andrew Waterhouse,Christine A Wells,Ole Winther,Linda Wu,Kazumi Yamaguchi,Hiroshi Yanagawa,Jun Yasuda,Mihaela Zavolan,David A Hume,Takahiro Arakawa,Shiro Fukuda,Kengo Imamura,Chikatoshi Kai,Ai Kaiho,Tsugumi Kawashima,Chika Kawazu,Yayoi Kitazume,Miki Kojima,Hisashi Miura,Kayoko Murakami,Mitsuyoshi Murata,Noriko Ninomiya,Hiromi Nishiyori,Shohei Noma,Chihiro Ogawa,Takuma Sano,Christophe Simon,Michihira Tagami,Yukari Takahashi,Jun Kawai,Yoshihide Hayashizaki, 2009年05月, Nature genetics, 41, 5, 553, 62

  DOI
• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, 2008年09月, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151

  DOI
• Interaction of anti-aggregation agent dimethylethylammonium propane sulfonate with acidic fibroblast growth factor, Long Xiang,Takeshi Ishii,Kazuo Hosoda,Ayumi Kamiya,Mayu Enomoto,Nobukazu Nameki,Yusuke Inoue,Kenji Kubota,Toshiyuki Kohno,Kaori Wakamatsu, 2008年09月, JOURNAL OF MAGNETIC RESONANCE, 194, 1, 147, 151

  DOI
• Hepatocyte nuclear factor 4 alpha in the intestinal epithelial cells protects against inflammatory bowel disease, Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,SunHee Yim,Gilles Lambert,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue, 2008年07月, INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease., Ahn\, S. H,Shar\, Y. M,Inoue\, J,Morimura\, K,Yim\, S. H,Lambert\, G,Kurotani\, R,Nagashima\, K,Gonzalez\, F. J,Inoue\, Y, 2008年07月, Inflamm. Bowel Dis., INFLAMMATORY BOWEL DISEASES, 14, 7, 908, 920

  DOI
• Hepatocyte Nuclear Factor 4 alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, 2015年12月, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865

  DOI
• Hepatocyte Nuclear Factor 4 alpha Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver, Shunsuke Matsuo,Masayuki Ogawa,Martina U. Muckenthaler,Yumiko Mizui,Shota Sasaki,Takafumi Fujimura,Masayuki Takizawa,Nagayuki Ariga,Hiroaki Ozaki,Masakiyo Sakaguchi,Frank J. Gonzalez,Yusuke Inoue, 2015年12月, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 52, 30855, 30865

  DOI
• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, 2013年09月, PLOS ONE, 8, 9, e74637

  DOI
• Regulation of the F11, Klkb1, Cyp4v3 Gene Cluster in Livers of Metabolically Challenged Mice, Huma Safdar,Audrey C. A. Cleuren,Ka Lei Cheung,Frank J. Gonzalez,Hans L. Vos,Yusuke Inoue,Pieter H. Reitsma,Bart J. M. van Vlijmen, 2013年09月, PLOS ONE, 8, 9, e74637

  DOI
• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, 2013年03月, ONCOLOGY REPORTS, 29, 3, 1073, 1079

  DOI
• DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells, Ken-Ichi Yamamoto,Hitoshi Murata,Endy Widya Putranto,Ken Kataoka,Akira Motoyama,Toshihiko Hibino,Yusuke Inoue,Masakiyo Sakaguchi,Nam-Ho Huh, 2013年03月, ONCOLOGY REPORTS, 29, 3, 1073, 1079

  DOI
• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, 2010年11月, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273

  DOI
• Solution Structure of the Catalytic Domain of the Mitochondrial Protein ICT1 That Is Essential for Cell Vitality, Yoshihiro Handa,Yusuke Hikawa,Naoya Tochio,Hiroyuki Kogure,Makoto Inoue,Seizo Koshiba,Peter Guentert,Yusuke Inoue,Takanori Kigawa,Shigeyuki Yokoyama,Nobukazu Nameki, 2010年11月, JOURNAL OF MOLECULAR BIOLOGY, 404, 2, 260, 273

  DOI
• The role of hepatocyte nuclear factor 4 alpha in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, H. Safdar,Y. Inoue,G. H. van Puijvelde,P. H. Reitsma,B. J. M. van Vlijmen, 2010年12月, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841, 速報，短報，研究ノート等（学術雑誌）

  DOI
• The role of hepatocyte nuclear factor 4α in regulating mouse hepatic anticoagulation and fibrinolysis gene transcript levels, Safdar\, H,Inoue\, Y,van Puijvelde\, G.H,Reitsma\, P.H,van Vlijmen\, B.J, 2010年12月, J. Thromb. Haemost., JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8, 12, 2839, 2841, 速報，短報，研究ノート等（学術雑誌）

  DOI
• Hepatocyte nuclear factor-4 alpha is essential for glucosestimulated insulin secretion by pancreatic beta-cells, A Miura,K Yamagata,M Kakei,H Hatakeyama,N Takahashi,K Fukui,T Nammo,K Yoneda,Y Inoue,FM Sladek,MA Magnuson,H Kasai,J Miyagawa,FJ Gonzalez,Shimomura\, I, 2006年02月, JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257

  DOI
• Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells., Miura\, A,Yamagata\, K,Kakei\, M,Hatakeyama\, H,Takahashi\, N,Fukui\, K,Nammo\, T,Yoneda\, K,Inoue\, Y,Sladek\, F. M,Magnuson\, M. A,Kasai\, H,Miyagawa\, J,Gonzalez\, F. J,Shimomura\, I, 2006年02月, J. Biol. Chem., JOURNAL OF BIOLOGICAL CHEMISTRY, 281, 8, 5246, 5257

  DOI
• Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4 alpha and peroxisome proliferator-activated receptor alpha, Mariko Shin,Insook Kim,Yusuke Inoue,Shioko Kimura,Frank J. Gonzalez, 2006年10月, MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290

  DOI
• Regulation of mouse hepatic α-amino β-carboxymuconate ε-semialdehyde decarboxylase, a key enzyme in the tryptophan-NAD pathway, by hepatocyte nuclear factor 4α and peroxisome-proliferator activated receptor α., Shin\, M,Kim\, I,Inoue\, Y,Kimura\, S,Gonzalez\, F. J, 2006年10月, Mol. Pharmacol., MOLECULAR PHARMACOLOGY, 70, 4, 1281, 1290

  DOI
• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4 alpha, Y Inoue,AM Yu,SH Yim,XC Ma,KW Krausz,J Inoue,CC Xiang,MJ Brownstein,G Eggertsen,Bjorkhem\, I,FJ Gonzalez, 2006年01月, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227

  DOI
• Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α., Inoue\, Y,Yu,A. M,Yim,S. H,Ma\, X,Krausz\, K. W,Inoue\, J,Xiang\, C. C,Brownstein\, M. J,Eggertsen\, G,Bjorkhem\, I,Gonzalez\, F. J, 2006年01月, J. Lipid Res, JOURNAL OF LIPID RESEARCH, 47, 1, 215, 227

  DOI
• Role of hepatocyte nuclear factor 4 alpha in control of blood coagulation factor gene expression, Y Inoue,LL Peters,SH Yim,J Inoue,FJ Gonzalez, 2006年04月, JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344

  DOI
• Role of hepatocyte nuclear factor 4α in control of blood coagulation factor gene expression., Inoue\, Y,Peters\, L. L,Yim\, S. H,Inoue\, J,Gonzalez\, F. J, 2006年04月, J. Mol. Med., JOURNAL OF MOLECULAR MEDICINE-JMM, 84, 4, 334, 344

  DOI
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, 2006年01月, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57

  DOI
• The effect of dimethyl sulfoxide on the function of cytochrome P450 2D6 in HepG2 cells upon the co-expression with NADPH-cytochrome P450 reductase, S Narimatsu,N Takatsu,S Yamano,Y Inoue,N Hanioka,K Kiryu,S Naito,FJ Gonzalez,S Yamamoto, 2006年01月, CHEMICO-BIOLOGICAL INTERACTIONS, 159, 1, 47, 57

  DOI
• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, 2007年06月, HEPATOLOGY, 45, 6, 1478, 1488

  DOI
• Glucocorticoid signaling synchronizes the liver circadian transcriptome, Akhilesh B. Reddy,Elizabeth S. Maywood,Natasha A. Karp,Verdun M. King,Yusuke Inoue,Frank J. Gonzalez,Kathryn S. Lilley,Charalambos P. Kyriacou,Michael H. Hastings, 2007年06月, HEPATOLOGY, 45, 6, 1478, 1488

  DOI
• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4 alpha, O Barbier,H Girard,Y Inoue,H Duez,L Villeneuve,A Kamiya,JC Fruchart,C Guillemette,FJ Gonzalez,B Staels, 2005年01月, MOLECULAR PHARMACOLOGY, 67, 1, 241, 249

  DOI
• Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4α., Barbier\, O,Girard\, H,Inoue\, Y,Duez\, H,Villeneuve\, L,Kamiya\, A,Fruchart\, J. C,Guillemette\, C,Gonzalez\, F. J,Staels\, B, 2005年01月, Mol. Pharmacol., MOLECULAR PHARMACOLOGY, 67, 1, 241, 249

  DOI
• Modulation of Mouse Coagulation Gene Transcription following Acute In Vivo Delivery of Synthetic Small Interfering RNAs Targeting HNF4 alpha and C/EBP alpha, Huma Safdar,Ka Lei Cheung,Hans L. Vos,Frank J. Gonzalez,Pieter H. Reitsma,Yusuke Inoue,Bart J. M. van Vlijmen, 2012年06月, PLOS ONE, 7, 6

  DOI
• Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα, Safdar\, H,Cheung\, K.L,Vos\, H.L,Gonzalez\, F.J,Reitsma\, P.H,Inoue\, Y,van Vlijmen\, B.J, 2012年06月, PLoS One, PLOS ONE, 7, 6

  DOI
• Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development., Kamiya\, A,Inoue\, Y,Gonzalez\, F. J, 2003年06月, Hepatology, HEPATOLOGY, 37, 6, 1375, 1384

  DOI
• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, 2003年08月, GASTROENTEROLOGY, 125, 2, 544, 555

  DOI
• Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression, T Claudel,Y Inoue,O Barbier,D Duran-Sandoval,Kosykh\, V,J Fruchart,JC Fruchart,FJ Gonzalez,B Staels, 2003年08月, GASTROENTEROLOGY, 125, 2, 544, 555

  DOI
• Regulation of hepatic fasting response by PPAR gamma coactivator-1 alpha (PGC-1): Requirement for hepatocyte nuclear factor 4 alpha in gluconeogenesis, J Rhee,Y Inoue,JC Yoon,P Puigserver,ML Fan,FJ Gonzalez,BM Spiegelman, 2003年04月, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017

  DOI
• Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis., Rhee\, J,Inoue\, Y,Yoon\, J. C,Puigserver\, P,Fan\, M,Gonzalez\, F. J,Spiegelman\, B. M, 2003年04月, Proc. Natl. Acad. Sci. USA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100, 7, 4012, 4017

  DOI
• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, 2004年04月, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862

  DOI
• Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors, Y Zhang,JJ Repa,Y Inoue,GP Hayhurst,FJ Gonzalez,DJ Mangelsdorf, 2004年04月, MOLECULAR ENDOCRINOLOGY, 18, 4, 851, 862

  DOI
• Hepatocyte nuclear factors 1 alpha and 4 alpha control expression of proline oxidase in adult liver, A Kamiya,Y Inoue,T Kodama,FJ Gonzalez, 2004年12月, FEBS LETTERS, 578, 1-2, 63, 68

  DOI
• Hepatocyte nuclear factor 4 alpha is a central regulator of bile acid conjugation, Y Inoue,AM Yu,J Inoue,FJ Gonzalez, 2004年01月, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489

  DOI
• Hepatocyte nuclear factor 4α is a central regulator of bile acid conjugation., Inoue\, Y,Yu\, A. M,Inoue\, J,Gonzalez\, F. J, 2004年01月, J. Biol. Chem., JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 4, 2480, 2489

  DOI
• Disruption of hepatic C/EBP alpha results in impaired glucose tolerance and age-dependent hepatosteatosis, Y Inoue,J Inoue,G Lambert,SH Yim,FJ Gonzalez, 2004年10月, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748

  DOI
• Disruption of hepatic C/EBPα results in impaired glucose tolerance and age-dependent hepatosteatosis., Inoue\, Y,Inoue\, J,Lambert\, G,Yim\, S. H,Gonzalez\, F. J, 2004年10月, J. Biol. Chem., JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 43, 44740, 44748

  DOI
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, 2016年12月, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

  DOI
• Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells., Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi, 2016年12月, Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 9, 2-3, 93, 105

  DOI
• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Hitoshi Murata,Masami Watanabe,Peng Huang,Rie Kinoshita,Junichiro Futami,Yusuke Inoue,Akira Yamauchi,I. Wayan Sumardika,Chen Youyi,Ken-Ichi Yamamoto,Yasutomo Nasu,Masahiro Nishibori,Toshihiko Hibino,Masakiyo Sakaguchi, 2016年08月, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627

  DOI
• MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappa B and ROS formation upon ligand binding, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Hitoshi Murata,Masami Watanabe,Peng Huang,Rie Kinoshita,Junichiro Futami,Yusuke Inoue,Akira Yamauchi,I. Wayan Sumardika,Chen Youyi,Ken-Ichi Yamamoto,Yasutomo Nasu,Masahiro Nishibori,Toshihiko Hibino,Masakiyo Sakaguchi, 2016年08月, CLINICAL & EXPERIMENTAL METASTASIS, 33, 6, 609, 627

  DOI
• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, 2016年11月, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250

  DOI
• Identification of an S100A8 Receptor Neuroplastin-beta and its Heterodimer Formation with EMMPRIN, Masakiyo Sakaguchi,Mami Yamamoto,Masashi Miyai,Tatsuo Maeda,Junichiro Hiruma,Hitoshi Murata,Rie Kinoshita,I. Made Winarsa Ruma,Endy Widya Putranto,Yusuke Inoue,Shin Morizane,Nam-Ho Huh,Ryoji Tsuboi,Toshihiko Hibino, 2016年11月, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136, 11, 2240, 2250

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, 2011年01月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717

  DOI
• Synthesis of modified siRNA bearing C-5 polyamine-substituted pyrimidine nucleoside in their 3 '-overhang regions and its RNAi activity, Mohammad Mehedi Masud,Tomokazu Masuda,Yusuke Inoue,Masayasu Kuwahara,Hiroaki Sawai,Hiroaki Ozaki, 2011年01月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21, 2, 715, 717

  DOI
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Hiroto Fujita,Yusuke Inoue,Masayasu Kuwahara, 2018年01月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1, 35, 39

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, 2014年07月, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218

  DOI
• Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells, I. Made Winarsa Ruma,Endy Widya Putranto,Eisaku Kondo,Risayo Watanabe,Ken Saito,Yusuke Inoue,Ken-Ichi Yamamoto,Susumu Nakata,Masaji Kaihata,Hitoshi Murata,Masakiyo Sakaguchi, 2014年07月, INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 1, 209, 218

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, 2014年07月, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630

  DOI
• Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene, Masakiyo Sakaguchi,Masami Watanabe,Rie Kinoshita,Haruki Kaku,Hideo Ueki,Junichiro Futami,Hitoshi Murata,Yusuke Inoue,Shun-Ai Li,Peng Huang,Endy Widya Putranto,I. Made Winarsa Ruma,Yasutomo Nasu,Hiromi Kumon,Nam-ho Huh, 2014年07月, MOLECULAR BIOTECHNOLOGY, 56, 7, 621, 630

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, 2014年08月, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402

  DOI
• DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes, Masakiyo Sakaguchi,Hitoshi Murata,Yumi Aoyama,Toshihiko Hibino,Endy Widya Putranto,I. Made Winarsa Ruma,Yusuke Inoue,Yoshihiko Sakaguchi,Ken-ichi Yamamoto,Rie Kinoshita,Junichiro Futami,Ken Kataoka,Keiji Iwatsuki,Nam-ho Huh, 2014年08月, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 34, 23389, 23402

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Aoi Morimoto,Mana Kannari,Yuichi Tsuchida,Shota Sasaki,Chinatsu Saito,Tsuyoshi Matsuta,Tsukasa Maeda,Megumi Akiyama,Takahiro Nakamura,Masakiyo Sakaguchi,Nobukazu Nameki,Frank J. Gonzalez,Yusuke Inoue, 2017年06月, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585

  DOI
• An HNF4-microRNA-194/192 signaling axis maintains hepatic cell function, Aoi Morimoto,Mana Kannari,Yuichi Tsuchida,Shota Sasaki,Chinatsu Saito,Tsuyoshi Matsuta,Tsukasa Maeda,Megumi Akiyama,Takahiro Nakamura,Masakiyo Sakaguchi,Nobukazu Nameki,Frank J. Gonzalez,Yusuke Inoue, 2017年06月, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 25, 10574, 10585

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, 2017年11月, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, 2017年11月, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, 2017年07月, ONCOLOGY LETTERS, 14, 1, 1041, 1048

  DOI
• Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3'-side of the transgene, Endy Widya Putranto,Rie Kinoshita,Masami Watanabe,Takuya Sadahira,Hitoshi Murata,Ken-Ichi Yamamoto,Junichiro Futami,Ken Kataoka,Yusuke Inoue,I. Made Winarsa Ruma,I. Wayan Sumardika,Chen Youyi,Miyoko Kubo,Yoshihiko Sakaguchi,Kenji Saito,Yasutomo Nasu,Hiromi Kumon,Nam-Ho Huh,Masakiyo Sakaguchi, 2017年07月, ONCOLOGY LETTERS, 14, 1, 1041, 1048

  DOI
• Hepatocyte nuclear factors 1α and 4α control expression of proline oxidase in adult liver., Kamiya\, A,Inoue\, Y,Kodama\, T,Gonzalez\, F. J, 2004年, FEBS Lett., 578, 63, 68

  DOI
• The orphan nuclear receptor HNF4 determines PXR, CAR and FXR-mediated induction by xenobiotics., Tirona\, R. G,Lee\, W,Leake\, B. F,Lan\, L. B,Brimer\, C,Lamda\, V,Parviz\, F,Duncan\, S. A,Inoue\, Y,Gonzalez\, F. J,Schuetz\, E. G,Kim\, R. B, 2003年, Nat. Med., 9, 220-224.

  DOI
• Serine/threonine phosphorylation regulates HNF-4 dependent redox mediated iNOS expression in hepatocytes., Guo\, H. T,Wei\, J. P,Inoue\, Y,Gonzalez\, F. J,Kuo\, P. C, 2003年, Am. J. Physiol. Cell Physiol., 284, C1090-1099.
• C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism; Cross-talk between C/EBP pathway and iron metabolism., Courselaud\, B,Pigeon\, C,Inoue\, Y,Inoue\, J,Gonzalez\, F. J,Leroyer\, P,Gilot\, D,Boudjema\, K,Guguen-Guillouzo\, C,Brissot\, P,Loreal\, O,Ilyin\, G, 2002年, J. Biol. Chem., 277, 41163-41170.

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi\, R,Gao\, C,Miyazaki\, M,Hamazaki\, K,Tsuji\, T,Inoue\, Y,Uemura\, T,Hirai\, R,Shimizu\, N,Namba\, M, 2001年, Anticancer Res., 21, 657-662.
• Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts., Sakaguchi\, M,Tsuji\, T,Inoue\, Y,Miyazaki\, M,Namba\, M,Yamada\, H,Tanaka\, T, 2001年, Radiat. Res., 155, 208-214.

  DOI
• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4α2 gene., Inoue\, Y,Miyazaki\, M,Tsuji\, T,Sakaguchi\, M,Fukaya\, K,Huh\, N. H,Namba\, M, 2001年, Int. J. Mol. Med., 84, 481-487.
• Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α); HNF4α regulates ornithine transcarbamylase in vivo., Inoue\, Y,Hayhurst\, G. P,Inoue\, J,Mori\, M,Gonzalez\, F. J, 2002年, J. Biol. Chem., 277, 25257-25265.
• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 and PGC-1., Hanniman\, E. A,Lambert\, G,Inoue\, Y,Gonzalez\, F. J,Sinal\, C. J, 2006年, J. Lipid Res., 47, 215, 227

  DOI
• Ohashi, R., Miyazaki, M., Fushimi, K., Tsuji, T., Inoue, Y., Shimizu, N., and Namba, M. (1999) Enhanced activity of cyclin A-associated kinase in immortalized human fibroblasts., 井上 裕介, 1999年, Int. J. Cancer, 82, 754-758.
• Mihara, K., Miyazaki, M., Fushimi, K., Tsuji, T., Inoue, Y., Fukaya, K., Ohashi, R., and Namba, M. (1997) The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory., 井上 裕介, 1997年, Tissue Cul. Res. Commun., 16, 173-178.
• Abe, E., Yuasa, T., Kondo, T., Kondo, Y., Tsuji, T., Inoue, Y., Fushimi, K., and Namba, M. (1996) Comparison of aging and immortalization process of cells derived from brains of newborn and old rats., 井上 裕介, 1996年, Tissue Cul. Res. Commun., 15, 179-185.
• Gao, C., Ohashi, R., Pu, H., Inoue, Y., Tsuji, T., Miyazaki, M., and Namba, M. (1999) Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma., 井上 裕介, 1999年, Oncol. Reports, 6, 1267-1271.
• Gao, C., Miyazaki, M., Ohashi, R., Tsuji, T., Inoue, Y., and Namba, M. (1999) Maintenance of near-diploid karyotype of PA-1 human ovarian teratocarcinoma cells due to death of polyploid cells by chromosome fragmentation/pulverization., 井上 裕介, 1999年, Int. J. Mol. Med., 4, 291-294.
• Tsuji, T., Miyazaki, M., Fushimi, K., Mihara, K., Inoue, Y., Ohashi, R., Ohtsubo, M., Hamazaki, K., Furusako, S., and Namba, M. (1998) Cyclin E overexpression responsible for growth of human hepatic tumors with p21WAF1/CIP1/SDI1., 井上 裕介, 1998年, Biochem. Biophys. Res. Commun., 242, 317-321.
• Katayama, B., Sakaguchi, M., Li, W. J., Pu, H., Inoue, Y., and Namba, M. (1998) ATP inhibition of proliferation of immortalized human fibroblasts is greater than that of normal diploid fibroblasts., 井上 裕介, 1998年, Int. J. Mol. Med., 2, 603-606.
• Li, J. W., Inoue, Y., Miyazaki, M., Pu, H., Kondo, A., and Namba, M. (2000) Growth inhibitory effects of ATP and its derivatives on human fibroblasts immortalized with 60Co-gamma rays., 井上 裕介, 2000年, Int. J. Mol. Med., 5, 59-62.
• Kobayashi, N., Fujiwara, T., Westerman, K. A., Inoue, Y., Sakaguchi, M., Noguchi, H., Miyazaki, M., Cai, J., Tanaka, N., Fox, I. J., and Leboulch, P. (2000) Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes., 井上 裕介, 2000年, Science, 287, 1258-1262.
• Gao, C., Miyazaki, M., Li, J. W., Tsuji, T., Inoue, Y., and Namba, M. (1999) Cytogenetic characteristics and p53 gene status of human teratocarcinoma PA-1 cells in 407-445 passages., 井上 裕介, 1999年, Int. J. Mol. Med., 4, 597-600.
• Fukaya, K., Miyazaki, M., Pu, H., Katayama, B., Inoue, Y., Ohashi, R., Nakamura, C., and Namba, M. (1997) Pyruvate alleviates toxic effects of ethanol on cells in culture., 井上 裕介, 1997年, Arch. Toxicol., 71, 651-654.
• Mihara, K., Miyazaki, M., Kondo, T., Fushimi, K., Tsuji, T., Inoue, Y., Fukaya, K., Ishioka, C., and Namba, M. (1997) Yeast functional assay of the p53 gene status in human cell lines maintain in our laboratory., 井上 裕介, 1997年, Acta Med. Okayama, 51, 261-265.
• Pu, H., Tsuji, T., Kondo, A., Fushimi, K., Ohashi, R., Inoue, Y., Mimura, T., Hamazaki, K., Miyazaki M, Namba M (1997) Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 genes., 井上 裕介, 1997年, Acta Med Okayama, 51, 313-319.
• Kondo, T., Mihara, K., Inoue, Y., and Namba, M. (1996) Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline1-oxide or 60Co gamma rays., 井上 裕介, 1996年, Electrophoresis, 17, 1638-1642.
• Namba, M., Mihara, K., Kondo, T., Inoue, Y., Tsuji, T., Fushimi, K., Shima, T., and Iijima, M. (1996) Immortalization of cultured human fibroblasts with the mutant p53 gene and X-rays., 井上 裕介, 1996年, Rad.？Oncol.？Invest., 3,?294-298.
• Kondo, T., Mihara, K., Inoue, Y., Iijima, M., and Namba, M. (1995) Two-dimensional electrophoretic analysis of down-regulated proteins in human fibroblasts immortalized by treatment with either 4-nitroquinoline1-oxide or 60Co gamma rays., 井上 裕介, 1996年, Electrophoresis, 16, 1067-1073.
• Uemura, T., Miyazaki, M., Hirai, R., Matsumoto, H., Ota, T., Ohashi, R., Shimizu, N., Tsuji, T., Inoue, Y., and Namba, M. (2000) Different expression of positive and negative regulators of hepatocyte growth in growing and shrinking hepatic lobes after ・・・, 井上 裕介, 2000年, Int. J. Mol. Med., 5, 173-179.
• Nozaki, I., Tsuji, T., Sakaguchi, M., Inoue, Y., Hirai, R., Andou, A., Miyazaki, M., Shimizu, N., and Namba, M. (2000) Establishment of a human hepatoma cell line, HLE/2E1, suitable for detection of P450 2E1-related cytotoxicity., 井上 裕介, 2000年, In Vitro Cell Dev. Biol. Anim., 36, 566-570.

  DOI
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Noguchi, H., Matsumura, T., Watanabe, T., Totsugawa, T., Tanaka, N., and Namba, M. (2000) Treatment of surgically induced acute liver failure with transplantation of highly differentiat・・・, 井上 裕介, 2000年, Cell Transplant., 9, 733-735.
• Sakaguchi, M., Miyazaki, M., Inoue, Y., Tsuji, T., Kouchi, H., Tanaka, T., Yamada, H., and Namba, M. (2000) Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts., 井上 裕介, 2000年, J. Cell. Biol., 149, 1193-1206.

  DOI
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Uemura, T., Noguchi, H., Kondo, A., Tanaka, N., and Namba, M. (2000) Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure., 井上 裕介, 2000年, Transplantation, 69, 202-207.
• Kobayashi, N., Miyazaki, M., Fukaya, K., Inoue, Y., Sakaguchi, M., Noguchi, H., Tanaka, N., and Namba M (2000) Establishment of a highly differentiated immortalized human hepatocyte cell line as a source of hepatic function in the bioartificial liver., 井上 裕介, 2000年, Transplant. Proc., 32, 237-241.
• Tsuji, T., Miyazaki, M., Sakaguchi, M., Inoue, Y., and Namba, M. (2000) A REIC gene shows down-regulation in human immortalized cells and humantumor-derived cell lines., 井上 裕介, 2000年, Biochem. Biophys. Res. Commun., 268, 20-24.
• Inoue, Y., Miyazaki, M., Ohashi, R., Tsuji, T., Fukaya, K., Kouchi, H., Uemura, T., Mihara, K., and Namba, M. (1998) Ubiquitous presence of cellular proteins that specifically bind to the 3' terminal region of hepatitis C virus., 井上 裕介, 1998年, Biochem. Biophys. Res. Commun., 245, 198-203.
• Oh, S. H., Miyazaki, M., Kouchi, H., Inoue, Y., Sakaguchi, M., Tsuji, T., Shima, N., Higashio, K., and Namba, M. (2000) Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. ・・・, 井上 裕介, 2000年, Biochem. Biophys. Res. Commun., 279, 500-504.
• Selective incorporation of foreign functionality into fibrin gels through a chemically modified DNA aptamer, Fujita\, Hiroto,Inoue\, Yusuke,Kuwahara\, Masayasu, 2018年, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 28, 1, 35, 39

  DOI
• Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development., Kamiya\, A,Inoue\, Y,Gonzalez\, F. J, 2003年, Hepatology, 37, 1375-1384.

  DOI
• The orphan nuclear receptor HNF4 determines PXR, CAR and FXR-mediated induction by xenobiotics., Tirona\, R. G,Lee\, W,Leake\, B. F,Lan\, L. B,Brimer\, C,Lamda\, V,Parviz\, F,Duncan\, S. A,Inoue\, Y,Gonzalez\, F. J,Schuetz\, E. G,Kim\, R. B, 2003年, Nat. Med., 9, 220-224.

  DOI
• Serine/threonine phosphorylation regulates HNF-4 dependent redox mediated iNOS expression in hepatocytes., Guo\, H. T,Wei\, J. P,Inoue\, Y,Gonzalez\, F. J,Kuo\, P. C, 2003年, Am. J. Physiol. Cell Physiol., 284, C1090-1099.
• C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism; Cross-talk between C/EBP pathway and iron metabolism., Courselaud\, B,Pigeon\, C,Inoue\, Y,Inoue\, J,Gonzalez\, F. J,Leroyer\, P,Gilot\, D,Boudjema\, K,Guguen-Guillouzo\, C,Brissot\, P,Loreal\, O,Ilyin\, G, 2002年, J. Biol. Chem., 277, 41163-41170.

  DOI
• Enhanced expression of cyclin E and cyclin A in human hepatocellular carcinomas., Ohashi\, R,Gao\, C,Miyazaki\, M,Hamazaki\, K,Tsuji\, T,Inoue\, Y,Uemura\, T,Hirai\, R,Shimizu\, N,Namba\, M, 2001年, Anticancer Res., 21, 657-662.
• Loss of Nuclear Localization of the S100C Protein in Immortalized Human Fibroblasts., Sakaguchi\, M,Tsuji\, T,Inoue\, Y,Miyazaki\, M,Namba\, M,Yamada\, H,Tanaka\, T, 2001年, Radiat. Res., 155, 208-214.

  DOI
• Reactivation of liver-specific gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4α2 gene., Inoue\, Y,Miyazaki\, M,Tsuji\, T,Sakaguchi\, M,Fukaya\, K,Huh\, N. H,Namba\, M, 2001年, Int. J. Mol. Med., 84, 481-487.
• Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4α (HNF4α); HNF4α regulates ornithine transcarbamylase in vivo., Inoue\, Y,Hayhurst\, G. P,Inoue\, J,Mori\, M,Gonzalez\, F. J, 2002年, J. Biol. Chem., 277, 25257-25265.
• Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 and PGC-1., Hanniman\, E. A,Lambert\, G,Inoue\, Y,Gonzalez\, F. J,Sinal\, C. J, 2006年, J. Lipid Res., 47, 215, 227

  DOI

講演・口頭発表等

• Maintenance of hepatic function by nuclear receptor HNF4α, Mini-symposium “Cellular sensing and maintenance, Inoue Y, Mini-symposium of Cellular sensing and maintenance, 2018年, 英語, 国際会議
• 肝臓特異的HNF4α欠損マウスで発現上昇する転写因子の機能解析, 安藤翔太朗, 井上裕介, 第41回日本分子生物学会, 2018年, 国内会議
• 肝臓HNF4αの標的タンパク質の同定, 生井美帆, 井上 裕介, 第41回日本分子生物学会, 2018年, 国内会議
• PPARαカスケードの活性化による新規NASH発症機構の解明, 笠野一郎, 瀧澤将行, 齊藤千夏, Frank J. Gonzalez,井上裕介, 第41回日本分子生物学会, 2018年, 国内会議
• 新規HNF4γバリアントによる肝機能の誘導, 佐々木翔太, 浦部瑞穂, 前田つかさ, 鈴木淳子, 入江亮太, 阪口政清, Frank J. Gonzalez, 井上裕介, 第41回日本分子生物学会, 2018年, 国内会議
• HNF4AとCREBHによる肝臓CIDEC2/Fsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩﨑若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank J. Gonzalez、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020年, 国内会議
• 肝がん細胞を抑制するSALL1の標的遺伝子の同定, 齋藤義文、安藤翔太朗、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020年, 国内会議
• miR-455を介した新規HNF4αカスケードの同定, 加藤佑弥、小菅優里、秋山萌、岩﨑若菜、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020年, 国内会議
• ヒト肺がん細胞で発現する核内受容体HNF4αの 機能解析, 黒田知紘、亀井めぐみ、井上裕介, 令和2年度日本化学会関東支部 群馬地区 研究交流発表会, 2020年, 国内会議
• 肝臓におけるHNF4α/miR-194-5p経路の標的遺伝子の探索, 岩崎若菜、守本葵、松田龍太郎、井上裕介, 第43回日本分子生物学会年会, 2020年, 国内会議
• HNF4αとCREBHによる肝臓のFsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩崎若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank Gonzalez、井上裕介, 第43回日本分子生物学会年会, 2020年, 国内会議
• 近位尿細管におけるHNF4αの標的遺伝子の同定, 淀美穂里、服部詩萌里、水野叶梧、柳田素子、井上裕介, 第43回日本分子生物学会年会, 2020年, 国内会議
• HNF4γ2に相互作用するタンパク質の探索, 江原伸哉、佐々木翔太、浦部 瑞穂、前田つかさ、鈴木淳子、入江亮太、鈴木正則、外丸靖浩、阪口政清、Gonzalez Frank、井上裕介, 第43回日本分子生物学会年会, 2020年, 国内会議
• 肝臓におけるHNF4α/miR-194経路の標的遺伝子の探索, 岩﨑若菜、守本葵、井上裕介, 第19回生体機能研究会, 2020年, 国内会議
• HNF4AとCREBHによる肝臓CIDE2/Fsp27bの相乗的な発現制御, 笠野一郎、瀧澤将行、岩﨑若菜、佐々木翔太、濱田夢芽、守本葵、阪口政清、Frank J Gonzalez、井上裕介, 第19回生体機能研究会, 2020年, 国内会議
• 肝臓におけるHNF4α/miR-194-5p経路の標的遺伝子の探索, 岩崎若菜、守本葵、松田龍太郎、井上裕介, 第43回日本分子生物学会年会, 国内会議
• 肺腺がん細胞における核内受容体HNF4αの機能解析と標的遺伝子の同定, 亀井めぐみ、濱田真輝、阪口政清、井上裕介, 第42回日本分子生物学会, 2019年, 国内会議
• miR-Xを介した肝臓の新規HNF4αカスケードの同定, 小菅優里、秋山萌、岩﨑若菜、井上裕介, 第42回日本分子生物学会, 2019年, 国内会議
• HNF4αを介した補体遺伝子C8γおよびC9の転写活性化機構の解析, 笠野一郎、大橋真衣子、横田聡美、坂本憲昭、Frank J. Gonzalez、井上裕介, 第42回日本分子生物学会, 2019年, 国内会議
• 肝臓特異的HNF4α欠損マウスにおけるHNF4γの機能解析, 第36回日本分子生物学会, 2013年
• PPARαカスケードの活性化は肝臓特異的HNF4α欠損マウスで脂肪肝を発症する, 第36回日本分子生物学会, 2013年
• 肝臓特異的HNF4α欠損マウスの血糖値低下機構の解明, 第36回日本分子生物学会, 2013年
• HNF4αによるmiR-194/192の発現制御機構の解析と標的遺伝子の同定, 第36回日本分子生物学会, 2013年
• 2型トランスフェリン受容体遺伝子の転写活性化機構の解析, 第36回日本分子生物学会, 2013年
• ミトコンドリアにおける翻訳停滞解消因子ICT1およびC12orf65の機能解析, 第15回日本RNA学会, 2013年
• PPARαカスケードの活性化による脂肪肝の発症, 第37回日本分子生物学会, 2014年
• miR-194/192を介した新規HNF4αネットワークの解明, 第37回日本分子生物学会, 2014年
• 肝臓特異的HNF4α欠損マウスにおけるHNF4γの機能解析, 第37回日本分子生物学会, 2014年
• miR-194/192を介した新規HNF4αネットワークの解明, 第16回日本RNA学会, 2014年
• Invastigation of a novel HNF4α network through miR-194/192., 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Enginering., 2014年
• Investigation of hepatic HNF4γ., International symposium on homeostasis through development, life and diseases., 2014年
• HNF4γの機能解析, 第38回日本生化学関東支部例会, 2015年
• Hepatic HNF4α cascade through modulation of miR-194/192., 2nd International Symposium of Gunma University Medical Innovation., 2015年
• HNF4γの転写活性化能の解析と相互作用タンパク質の探索, 第38回日本分子生物学会, 2015年
• HNF4αはmiR-194/192を介して肝細胞の脱分化を抑制する, 第38回日本分子生物学会, 2015年
• HNF4αによる補体遺伝子C8γの転写活性化機構の解析, 第36回日本分子生物学会, 2013年
• HNF4αによるmiR-194/192の発現制御機構の解析と標的遺伝子の同定, 第15回日本RNA学会, 2013年
• HNF4αによる肺がん形成、進行への影響, 第39回日本分子生物学会, 2016年
• 肝臓特異的HNF4α欠損マウスの血糖値低下機構の解析, 第39回日本分子生物学会, 2016年
• PPARαカスケードの活性化による脂肪肝の発症, 第39回日本分子生物学会, 2016年
• Positive regulation of hepatic miRNA by HNF4α, 3rd international symposium of GUMI&AMDE 2016, 2016年
• Invastigation of a novel HNF4α network through miR-194/192., 1st International Symposium of Gunma University Medical Innovation and 6th International Conference on Advanced Micro-Device Enginering., 2014年
• Investigation of hepatic HNF4γ., International symposium on homeostasis through development, life and diseases., 2014年
• Hepatic HNF4α cascade through modulation of miR-194/192., 2nd International Symposium of Gunma University Medical Innovation., 2015年
• Positive regulation of hepatic miRNA by HNF4α, 3rd international symposium of GUMI&AMDE 2016, 2016年

産業財産権

• 特許権, 抗S100A8/A9抗体, 阪口政清，豊岡伸一，冨田秀太，枝園和彦，佐藤博紀，木下理恵，二見淳一郎，荒木恒太，岡崎幹生，近藤英作，井上裕介，山内明, 特願2018-087576, 2018年04月27日, 国立大学法人岡山大学、国立大学法人新潟大学、国立大学法人群馬大学、学校法人川崎学園, はい, はい

受賞

• The Fellows Award For Research Excellence 2003, 2003年
• The Fellows Award For Research Excellence 2005, 2005年
• 優秀ポスター賞, 2016年
• The Fellows Award For Research Excellence 2003, 2003年
• The Fellows Award For Research Excellence 2005, 2005年

共同研究・競争的資金等の研究課題

• 非アルコール性脂肪性肝炎と肝細胞癌に関与するmiR-194/192の標的遺伝子の同定, 井上裕介, 群馬大学生体調節研究所, 「内分泌・代謝学共同研究拠点」共同研究, 2020年, 競争的資金, 国際共著していない
• 核内受容体のクロストークによるインスリン非依存性の新規の非アルコール性脂肪性肝炎の発症機序の解明, 井上裕介, 武田科学振興財団, 武田科学振興財団生命科学研究助成, 2019年, 研究代表者, 競争的資金, 国際共著していない
• 肝臓特異的HNF4α欠損マウスにおける脂肪肝発生機構の解明, 井上 裕介, 小野医学研究財団, 研究奨励助成, 2005年, 2006年, 研究代表者, 競争的資金
• 肝臓における遺伝子発現制御ネットワークの解明, 井上 裕介, 日揮･実吉奨学会, 研究助成制度, 2009年, 2010年, 研究代表者, 競争的資金
• 肝臓特異的 HNF4α欠損マウスにおける鉄代謝異常の分子機構の解明, 井上 裕介, 加藤記念バイオサイエンス研究振興財団, 研究助成金, 2005年, 2006年, 研究代表者, 競争的資金
• 核内受容体HNF4αを介したグルカゴン受容体の発現制御ネットワークの解明, 井上 裕介, 武田科学振興財団, 医学系研究奨励, 2010年, 2011年, 研究代表者, 競争的資金
• 核内受容体による非アルコール性脂肪肝炎発症経路の解明と治療応用への基盤構築, 井上 裕介, 基盤研究(C), 2013年, 2016年, 研究代表者, 競争的資金
• 核内受容体を介した新規NAFLD/NASH発症・進展機構の解明, 井上 裕介, ブリストル・マイヤーズ・スクイブ, 非アルコール性脂肪性肝疾患研究助成, 2017年, 2018年, 研究代表者, 競争的資金
• 脂肪肝改善に関与する核内受容体の研究：新規病態モデルの確立と治療応用への展開, 井上 裕介, 独立行政法人 日本学術振興会, 基盤研究(C), 2010年, 2012年, 研究代表者, 競争的資金
• 核内受容体HNF4αとPPARによるNASH発症機序の解明と治療応用への基礎研究, 井上 裕介, 独立行政法人 日本学術振興会, 基盤研究(C), 2016年, 2019年, 研究代表者, 競争的資金

社会貢献活動情報

社会貢献活動

• 博士学生の米国派遣, 2022年, 9999年
• 食品科学特論, 2023年11月17日, 2023年11月17日
• 出張模擬授業（渋川高校）, 2023年11月17日, 2023年11月17日（対象：高校生）
• 食品科学特論の運営, 2021年11月12日, 2021年11月19日, その他（対象：大学生, 大学院生, 教育関係者, 研究者, 社会人・一般, 企業, 市民団体, 行政機関）
• 出前授業（佐野東高校）, 佐野東高校, 令和3年度　佐野東高一日大学, 2021年06月18日, 2021年06月18日, 佐野東高校, 出前授業（対象：高校生, 教育関係者）