研究者データベース
| 森口 朋尚 |  |
| モリグチ トモヒサ | |
| 分子科学部門 | |
| 准教授 | |
Last Updated :2024/03/29
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森口 朋尚, モリグチ トモヒサ
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森口, 朋尚研究者氏名（カナ）
モリグチ, トモヒサ
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論文
- Alternate stranded triplex formation of chimeric DNA composed of tandem a- and b-anomeric strands, Kazuo Shinozuka / Noritake Matsumoto / Hideo Suzuki / Tomohisa Moriguchi / Hiroaki Sawai, 2002年11月, J. Chem. Soc. Chem. Comm.
- Unique participation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of Si-O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5' -terminal guanylated oligodeoxynucleotides, Masatoshi Ushioda / Michinori Kadokura / Tomohisa Moriguchi / Akio Kobori / Morihiro Aoyagi / Kohji Seio / Mitsuo Sekine, 2002年09月, Helvetica Chimica Acta
- Solid phase synthesis of a 5' -terminal TMG-capped trinucleotide block of U1 snRNA, Michinori Kadokura / Takeshi Wada / Kohji Seio / Tomohisa Moriguchi / Jochen Huber / Reinhard Luhrmann / Mitsuo Sekine, 2001年11月, Tetrahedron Letters
- Total synthesis of agrocin 84 and phosmidosine as naturally occurring nucleotidic antiboitics having P-N bond linkages, Mitsuo Sekine / Tomohisa Moriguchi / Takeshi Wada / Kohji Seio, 2001年11月, 有機合成化学協会誌
- Novel fluorescent oligo-DNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher, MORIGUCHI TOMOHISA / SHINOZUKA KAZUO / SAWAI HIROAKI, 2006年05月, Bioorganic and Medicial Chemistry Letters
- Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence, MORIGUCHI TOMOHISA / SHINOZUKA KAZUO, 2004年03月, Bioorganic and Medicinal Chemistry Letters
- Synthesis of enol adenosine 5'-phosphate derivatives by the Perkow reaction of a silylated adenosine 5'-phosphonate derivative with a-halo ketones, MORIGUCHI TOMOHISA / 関根 光雄, 2004年03月, Letters in Organic Chemistry
- Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix, MIYASITA MASANOR/MATSUMOTO NORITAKE/MORIGUCHI TOMOHISA/SHINOZUKA KAZUO, 2003年11月, Tetrahedron Letters
- Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position, MORIGUCHI TOMOHISA / SHINOZUKA KAZUO, 2006年04月, Nucleosides Nucleotides Nucleic Acids
- Modified a-b chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability, MORIGUCHI TOMOHISA / SHINOZUKA KAZUO, 2006年02月, Chemical Communications
- Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA, MORIGUCHI TOMOHISA / 関根 光雄 / 西川 一八, 2006年04月, Protein and Peptide Letters
- First synthesis and anti-cancer activity of phosmidosine and its related compounds, MORIGUCHI TOMOHISA / 関根 光雄, 2002年05月, Journal of Organic Chemistry
- Synthesis and properties of oligodeoxynucleotides having an N-phosphoryl group, MORIGUCHI TOMOHISA / 関根 光雄, 2003年06月, European Journal of Organic Chemistry
- Synthesis and stability of 1-phenylethynyl phosphate derivatives and their phosphoryl transfer activity, MORIGUCHI TOMOHISA / 関根 光雄, 2004年02月, Letters in Organic Chemistry
- Formation and stability of alternate-stranded triplex formed with alpha, beta-chimeric oligoDNA, Yoshihiro Hirose, Aimi Kadoya, Noritake Matsumoto, Takanori Miyashita, Tomohisa Moriguchi, Kazuo Shinozuka, 2002年11月, Nucleic Acids Research Supplement
- α-β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves the thermal stability of an alternate-stranded triple helix, MORIGUCHI TOMOHISA / SHINOZUKA KAZUO, 2004年12月, Bioorganic and Medicinal Chemistry Letters
- Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms, Masaru Tsunoda, Yoshio Kusakabe, Nobutada Tanaka, Satoshi Ohno, Masashi Nakamura, Toshiya Senda, Tomohisa Moriguchi, Norio Asai, Mitsuo Sekine, Takashi Yokogawa, Kazuya Nishikawa, and Kazuo T. Nakamura, 2007年07月, Nucleic Acids Research
- Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis, Tomohisa Moriguchi, Tomoyuki Ohike, Kazuo Shinozuka, 2006年11月, Nucleic Acids Symposium Series
- Investigation of antisense DNA having C-5 polyamine substituted 2’-deoxyuridine derivative, Hideaki Sakai, Tomohisa Moriguchi, Hideo Suzuki, Makoto Matsukura, Kazuo Shinozuka, 2001年11月, Nucleic Acids Research Supplement, 1
- Synthesis of small multifunctional molecules having nucleic acid binding property, Kumiko Nakanuma, Tomohisa Moriguchi, Hideo Suzuki, Kazuo Shinozuka, 2001年11月, Nucleic Acids Research Supplement
- Spermine Moiety Attached to the C-5 Position of Deoxyuridine Enhances the Duplex Stability of the Phosphorothioate DNA/Complementary DNA and Shows the Susceptibility of the Substrate to RNase H, T. Moriguchi, H. Sakai, H. Suzuki, K. Shinozuka, 2008年04月, Chem Pharm. Bull.
- Synthesis and Properties of Oligonucleotides Containing Silylated Pyrene Derivatives, T. Moriguchi, M. Hattori, T. Sekiguchi, M. Ichimura, K. Shinozuka, 2008年11月, Nucleid Acids Res. Symp. Ser.,
- Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds, 2009年04月, Chem. Lett
- Investigation of the mechanism of the fluorescent emmision of the silylated pyrene-modified DNA., T. Moriguchi, M. Hattori, M. Sekiguchi, K. Shinozuka, 2009年11月, Nucleic Acids Res. Sym. Ser.
- Synthesis and properties of novel oligodeoxynucleotides containing 6,3'-methanodeoxyuridine, Tomohisa Moriguchi, Fumisada Yamato, Kazuo Shinozuka, 2008年05月, Chemistry Letters
- Synthesis and Properties of Fluorescent Biological Molecules Labeled with Novel Silylated Perylene Derivative, , Y. Sato, A. Ozaki, M. Hosaka, T. Moriguchi, K. Shinozuka,, 2011年, Key Engineering Materials,
- Modified OligoDNA having Two Consecutive Silylated-pyrene Moieties in Minor Groove Exhibiting an Excimer Fluorescent Signal upon Binding to Fully-complementary DNA Strand,, M. Mogi, M.D. Gias Uddine, M. Ichimura, T. Moriguchi, K. Shinozuka, , 2010年11月, Chem. Lett.,
- Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells, , M. Tsuchiya, M. Hosaka, T. Moriguchi, S. Zhang, M. Suda, H. Yokota-Hashimoto, K. Shinozuka, T. Takeuchi, , 2010年10月, Endoclinology,
- Stabilizing Effectof Propionic Acid Derivative of Anthraquinone-Polyamine Conjugate Incorporated into Chimeric Oligonucleotides on the Alternate-Stranded Triple Helix, T. Moriguchi, A.T.M. Zafrul Azam, K. Shinozuka, 2011年06月, Bioconjugate Chemistry
- Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore, Chowdhury, Jakir Ahmed; Moriguchi, Tomohisa; Shinozuka, Kazuo, 2015年, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5 '-Terminus, Moriguchi, Tomohisa; Moki, Daisuke; Sekiguchi, Tohru; Kato, Takahiko; Shinozuka, Kazuo, 2015年, CHEMISTRY LETTERS
- Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA, Moriguchi, Tomohisa; Hida, Satomi; Yoneda, Fumio; Shinozuka, Kazuo, 2015年, AUSTRALIAN JOURNAL OF CHEMISTRY
- Development of a Novel Stem-loop-type Molecular Beacon Probe Possessing Polyamine-connected Deoxyuridine and Silylated Pyrene, Chowdhury, Jakir Ahmed; Moriguchi, Tomohisa; Shinozuka, Kazuo, 2014年12月, CHEMISTRY LETTERS
- Development of the excimer probe responsible for DNA target bearing the silylated pyrenes at base moiety, Moriguchi, Tomohisa; Ichimura, Mayumi; Kato, Mitsuhisa; Suzuki, Kenya; Takahashi, Yuki; Shinozuka, Kazuo, 2014年, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage, Moriguchi, Tomohisa; Sekine, Mitsuaki; Shinozuka, Kazuo, 2013年12月, BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and properties of molecular beacon DNA probe bearing novel silylated pyrene derivative, Md. Gias Uddin, T. Moriguchi, M. Ichimura, K. Shinozuka, 2012年06月, Key Engineering Materials
- Termini-free molecular beacon utilizing silylated perylene and anthraquinone attached to the C-5 position of pyrimidine nucleobase, Y. Sato, T. Moriguchi, K. Shinozuka, 2012年06月, Chem. Lett.,
- Investigation of the mechanism of the fluorescent emission of the silylated pyrene modified DNA, Tomohisa Moriguchi, Masayoshi Hattori, Tohru Sekiguchi, Kazuo Shinozuka, 2009年11月, Nucleic Acids Symp. Ser
MISC
- Spermine moiety attached to the C-5 position of deoxyuridine enhances the duplex stability of the phosphorothioate DNA/complementary DNA and shows the susceptibility of the substrate to RNase H, Tomohisa Moriguchi; Hideaki Sakai; Hideo Suzuki; Kazuo Shinozuka, 2008年09月, CHEMICAL & PHARMACEUTICAL BULLETIN, 56, 9, 1259, 1263
- Spermine moiety attached to the C-5 position of deoxyuridine enhances the duplex stability of the phosphorothioate DNA/complementary DNA and shows the susceptibility of the substrate to RNase H, Tomohisa Moriguchi; Hideaki Sakai; Hideo Suzuki; Kazuo Shinozuka, 2008年09月, CHEMICAL & PHARMACEUTICAL BULLETIN, 56, 9, 1259, 1263
- Synthesis and properties of novel oligodeoxynucleotides containing 6,3 '-methanodeoxyuridine, Tomohisa Moriguchi; Fumisada Yaniato; Kazuo Shinozuka, 2008年05月, CHEMISTRY LETTERS, 37, 5, 548, 549
- Solid-phase synthesis of a 5 '-terminal TMG-capped trinucleotide block of U1 snRNA, M Kadokura; T Wada; K Seio; T Moriguchi; J Huber; R Luhrmann; M Sekine, 2001年12月, TETRAHEDRON LETTERS, 42, 50, 8853, 8856
- Solid-phase synthesis of a 5 '-terminal TMG-capped trinucleotide block of U1 snRNA, M Kadokura; T Wada; K Seio; T Moriguchi; J Huber; R Luhrmann; M Sekine, 2001年12月, TETRAHEDRON LETTERS, 42, 50, 8853, 8856
- Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5 '-Terminus, Tomohisa Moriguchi; Daisuke Moki; Tohru Sekiguchi; Takahiko Kato; Kazuo Shinozuka, 2015年01月, CHEMISTRY LETTERS, 44, 1, 44, 46
- Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5 '-Terminus, Tomohisa Moriguchi; Daisuke Moki; Tohru Sekiguchi; Takahiko Kato; Kazuo Shinozuka, 2015年01月, CHEMISTRY LETTERS, 44, 1, 44, 46
- Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore, Jakir Ahmed Chowdhury; Tomohisa Moriguchi; Kazuo Shinozuka, 2015年03月, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88, 3, 496, 502
- Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA, Tomohisa Moriguchi; Satomi Hida; Fumio Yoneda; Kazuo Shinozuka, 2015年, AUSTRALIAN JOURNAL OF CHEMISTRY, 68, 2, 256, 259
- Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA, Tomohisa Moriguchi; Satomi Hida; Fumio Yoneda; Kazuo Shinozuka, 2015年, AUSTRALIAN JOURNAL OF CHEMISTRY, 68, 2, 256, 259
- Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds, Tomohisa Moriguchi; Masahiro Hosaka; Akihito Yoshinari; Akiko Ozaki; Toshiyuki Takeuchi; Kazuo Shinozuka, 2009年10月, CHEMISTRY LETTERS, 38, 10, 966, 967
- Cholesterol Analogs Labeled with Novel Silylated Fluorescent Compounds, Tomohisa Moriguchi; Masahiro Hosaka; Akihito Yoshinari; Akiko Ozaki; Toshiyuki Takeuchi; Kazuo Shinozuka, 2009年10月, CHEMISTRY LETTERS, 38, 10, 966, 967
- Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage, Tomohisa Moriguchi; Mitsuaki Sekine; Kazuo Shinozuka, 2013年12月, BIOORGANIC & MEDICINAL CHEMISTRY, 21, 24, 8013, 8018
- Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic beta-Cells, Miho Tsuchiya; Masahiro Hosaka; Tomohisa Moriguchi; Shaojuan Zhang; Masayuki Suda; Hiromi Yokota-Hashimoto; Kazuo Shinozuka; Toshiyuki Takeuchi, 2010年10月, ENDOCRINOLOGY, 151, 10, 4705, 4716
- Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells,, M. Tsuchiya; M. Hosaka; T. Moriguchi; S. Zhang; M. Suda; H. Yokota-Hashimoto; K. Shinozuka; T. Takeuchi, 2010年10月, Endoclinology,, ENDOCRINOLOGY, 151, 10, 4705, 4716
- Modified OligoDNA Having Two Consecutive Silylated-pyrene Moieties in Minor Groove Exhibiting an Excimer Fluorescent Signal upon Binding to Fully Complementary DNA Strand, Mika Mogi; Md Gias Uddin; Mayumi Ichimura; Tomohisa Moriguchi; Kazuo Shinozuka, 2010年12月, CHEMISTRY LETTERS, 39, 12, 1254, 1255
- Modified OligoDNA Having Two Consecutive Silylated-pyrene Moieties in Minor Groove Exhibiting an Excimer Fluorescent Signal upon Binding to Fully Complementary DNA Strand, Mika Mogi; Md Gias Uddin; Mayumi Ichimura; Tomohisa Moriguchi; Kazuo Shinozuka, 2010年12月, CHEMISTRY LETTERS, 39, 12, 1254, 1255
- Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher, S Kodama; S Asano; T Moriguchi; H Sawai; K Shinozuka, 2006年05月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 10, 2685, 2688
- Novel fluorescent oligoDNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher, S Kodama; S Asano; T Moriguchi; H Sawai; K Shinozuka, 2006年05月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16, 10, 2685, 2688
- Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA, Y Kusakabe; S Ohno; N Tanaka; M Nakamura; M Tsunoda; T Moriguchi; N Asai; M Sekine; T Yokogawa; K Nishikawa; KT Nakamura, 2006年, PROTEIN AND PEPTIDE LETTERS, 13, 4, 417, 419
- Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA, Y Kusakabe; S Ohno; N Tanaka; M Nakamura; M Tsunoda; T Moriguchi; N Asai; M Sekine; T Yokogawa; K Nishikawa; KT Nakamura, 2006年, PROTEIN AND PEPTIDE LETTERS, 13, 4, 417, 419
- Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position, Tomohisa Moriguchi; Hirokazu Sekiguchi; Makoto Tachibana; Kazuo Shinozuka, 2006年, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 25, 4-6, 601, 612
- Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position, Tomohisa Moriguchi; Hirokazu Sekiguchi; Makoto Tachibana; Kazuo Shinozuka, 2006年, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 25, 4-6, 601, 612
- Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms, Masaru Tsunoda; Yoshio Kusakabe; Nobutada Tanaka; Satoshi Ohno; Masashi Nakamura; Toshiya Senda; Tomohisa Moriguchi; Norio Asai; Mitsuo Sekine; Takashi Yokogawa; Kazuya Nishikawa; Kazuo T. Nakamura, 2007年, NUCLEIC ACIDS RESEARCH, 35, 13, 4289, 4300
- Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms, Masaru Tsunoda; Yoshio Kusakabe; Nobutada Tanaka; Satoshi Ohno; Masashi Nakamura; Toshiya Senda; Tomohisa Moriguchi; Norio Asai; Mitsuo Sekine; Takashi Yokogawa; Kazuya Nishikawa; Kazuo T. Nakamura, 2007年, NUCLEIC ACIDS RESEARCH, 35, 13, 4289, 4300
- Synthesis and Properties of Molecular Beacon DNA Probe Bearing Novel Silylated Pyrene Derivative, Md Gias Uddin; Tomohisa Moriguchi; Mayumi Ichimura; Kazuo Shinozuka, 2012年, SILICON SCIENCE AND ADVANCED MICRO-DEVICE ENGINEERING II, 497, 47, +
- Synthesis and Properties of Molecular Beacon DNA Probe Bearing Novel Silylated Pyrene Derivative, Md Gias Uddin; Tomohisa Moriguchi; Mayumi Ichimura; Kazuo Shinozuka, 2012年, SILICON SCIENCE AND ADVANCED MICRO-DEVICE ENGINEERING II, 497, 47, +
- Termini-free Molecular Beacon Utilizing Silylated Perylene and Anthraquinone Attached to the C-5 Position of Pyrimidine Nucleobase, Yuzuru Sato; Tomohisa Moriguchi; Kazuo Shinozuka, 2012年04月, CHEMISTRY LETTERS, 41, 4, 420, 422
- Unique participation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si-O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5 '-terminal guanylated oligodeoxynucleotides, M Ushioda; M Kadokura; T Moriguchi; A Kobori; M Aoyagi; K Seio; M Sekine, 2002年, HELVETICA CHIMICA ACTA, 85, 9, 2930, 2945
- Unique participation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si-O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5 '-terminal guanylated oligodeoxynucleotides, M Ushioda; M Kadokura; T Moriguchi; A Kobori; M Aoyagi; K Seio; M Sekine, 2002年, HELVETICA CHIMICA ACTA, 85, 9, 2930, 2945
- First synthesis and anticancer activity of phosmidosine and its related compounds, T Moriguchi; N Asai; K Okada; K Seio; T Sasaki; M Sekine, 2002年05月, JOURNAL OF ORGANIC CHEMISTRY, 67, 10, 3290, 3300
- First synthesis and anticancer activity of phosmidosine and its related compounds, T Moriguchi; N Asai; K Okada; K Seio; T Sasaki; M Sekine, 2002年05月, JOURNAL OF ORGANIC CHEMISTRY, 67, 10, 3290, 3300
- Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix, T Miyashita; N Matsumoto; T Moriguchi; K Shinozuka, 2003年09月, TETRAHEDRON LETTERS, 44, 40, 7399, 7402
- Novel dinucleoside phosphotriester unit conjugated with an intercalative moiety in a stereospecific manner enhances thermal stability of an alternate-stranded triple helix, T Miyashita; N Matsumoto; T Moriguchi; K Shinozuka, 2003年09月, TETRAHEDRON LETTERS, 44, 40, 7399, 7402
- alpha-beta Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix, ATMZ Azam; M Hasegawa; T Moriguchi; K Shinozuka, 2004年12月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 23, 5747, 5750
- α-β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves the thermal stability of an alternate-stranded triple helix, MORIGUCHI TOMOHISA; SHINOZUKA KAZUO, 2004年12月, Bioorganic and Medicinal Chemistry Letters, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 23, 5747, 5750
- Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence, M Sato; T Moriguchi; K Shinozuka, 2004年03月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 5, 1305, 1308
- Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphodiester linkage facilitates triplex formation with dsDNA bearing a pyrimidine-gapped polypurine sequence, M Sato; T Moriguchi; K Shinozuka, 2004年03月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14, 5, 1305, 1308
- Synthesis and stability of 1-phenylethenyl phosphate derivatives and their phosphoryl transfer activity, T Moriguchi; K Okada; K Seio; M Sekine, 2004年04月, LETTERS IN ORGANIC CHEMISTRY, 1, 2, 140, 144
- Synthesis and stability of 1-phenylethenyl phosphate derivatives and their phosphoryl transfer activity, T Moriguchi; K Okada; K Seio; M Sekine, 2004年04月, LETTERS IN ORGANIC CHEMISTRY, 1, 2, 140, 144
- Synthesis of enol adenosine 5 '-phosphate derivatives by the Perkow reaction of a silylated adenosine 5 '-phosphonate derivative with alpha-halo ketones, T Moriguchi; K Okada; K Seio; M Sekine, 2004年07月, LETTERS IN ORGANIC CHEMISTRY, 1, 3, 246, 248
- Synthesis of enol adenosine 5 '-phosphate derivatives by the Perkow reaction of a silylated adenosine 5 '-phosphonate derivative with alpha-halo ketones, T Moriguchi; K Okada; K Seio; M Sekine, 2004年07月, LETTERS IN ORGANIC CHEMISTRY, 1, 3, 246, 248
- Stabilizing Effect of Propionic Acid Derivative of Anthraquinone-Polyamine Conjugate Incorporated into alpha-beta Chimeric Oligonucleotides on the Alternate-Stranded Triple Helix, Tomohisa Moriguchi; A. T. M. Zafrul Azam; Kazuo Shinozuka, 2011年06月, BIOCONJUGATE CHEMISTRY, 22, 6, 1039, 1045
- Synthesis and Properties of Fluorescent Biological Molecules Labeled with Novel Silylated Perylene Derivative, Yuzuru Sato; Akiko Ozaki; Masahiro Hosaka; Tomohisa Moriguchi; Kazuo Shinozuka, 2011年, SILICON SCIENCE AND ADVANCED MICRO-DEVICE ENGINEERING I, 459, 63, +
- Synthesis and Properties of Fluorescent Biological Molecules Labeled with Novel Silylated Perylene Derivative, Yuzuru Sato; Akiko Ozaki; Masahiro Hosaka; Tomohisa Moriguchi; Kazuo Shinozuka, 2011年, SILICON SCIENCE AND ADVANCED MICRO-DEVICE ENGINEERING I, 459, 63, +
- Development of a Novel Stem-loop-type Molecular Beacon Probe Possessing Polyamine-connected Deoxyuridine and Silylated Pyrene, Jakir Ahmed Chowdhury; Tomohisa Moriguchi; Kazuo Shinozuka, 2014年12月, CHEMISTRY LETTERS, 43, 12, 1915, 1917
- Development of the excimer probe responsible for DNA target bearing the silylated pyrenes at base moiety, Tomohisa Moriguchi; Mayumi Ichimura; Mitsuhisa Kato; Kenya Suzuki; Yuki Takahashi; Kazuo Shinozuka, 2014年09月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24, 18, 4372, 4375
- Development of the excimer probe responsible for DNA target bearing the silylated pyrenes at base moiety, Tomohisa Moriguchi; Mayumi Ichimura; Mitsuhisa Kato; Kenya Suzuki; Yuki Takahashi; Kazuo Shinozuka, 2014年09月, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 24, 18, 4372, 4375
- Alternate stranded triplex formation of chimeric DNA composed of tandem a- and b-anomeric strands, Kazuo Shinozuka; Noritake Matsumoto; Hideo Suzuki; Tomohisa Moriguchi; Hiroaki Sawai, 2002年, J. Chem. Soc. Chem. Comm., 2712-13
- Total synthesis of agrocin 84 and phosmidosine as naturally occurring nucleotidic antibiotics having P-N bond linkages, Mitsuo Sekine; Tomohisa Moriguchi; Takeshi Wada; Kohji Seio, 2001年, Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 59, 11, 1109, 1120, 書評論文,書評,文献紹介等
- Modified a-b chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability, MORIGUCHI TOMOHISA; SHINOZUKA KAZUO, 2006年, Chemical Communications, pp 335-337
- Synthesis and properties of oligodeoxynucleotides having an N-phosphoryl group, MORIGUCHI TOMOHISA; 関根 光雄, 2003年, European Journal of Organic Chemistry, pp. 2260-67
- Synthesis of small multifunctional molecules having nucleic acid binding property, Kumiko Nakanuma; Tomohisa Moriguchi; Hideo Suzuki; Kazuo Shinozuka, 2001年, Nucleic Acids Research Supplement, 1, 69, 70
- Formation and stability of alternate-stranded triplex formed with alpha, beta-chimeric oligoDNA, Yoshihiro Hirose; Aimi Kadoya; Noritake Matsumoto; Takanori Miyashita; Tomohisa Moriguchi; Kazuo Shinozuka, 2002年, Nucleic Acids Research Supplement, 2, 263, 264
- Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis, Tomohisa Moriguchi; Tomoyuki Ohike; Kazuo Shinozuka, 2006年, Nucleic Acids Symposium Series, 50, 187, 188
- Investigation of antisense DNA having C-5 polyamine substituted 2’-deoxyuridine derivative, Hideaki Sakai; Tomohisa Moriguchi; Hideo Suzuki; Makoto Matsukura; Kazuo Shinozuka, 2001年, Nucleic Acids Research Supplement, 1
- Investigation of the mechanism of the fluorescent emmision of the silylated pyrene-modified DNA., T. Moriguchi; M. Hattori; M. Sekiguchi; K. Shinozuka, 2009年, Nucleic Acids Res. Sym. Ser., 53, 31, 32
- Synthesis and Properties of Oligonucleotides Containing Silylated Pyrene Derivatives, T. Moriguchi; M. Hattori; T. Sekiguchi; M. Ichimura; K. Shinozuka, 2008年, Nucleid Acids Res. Symp. Ser.,, 52, 255, 256
- Stabilizing Effectof Propionic Acid Derivative of Anthraquinone-Polyamine Conjugate Incorporated into Chimeric Oligonucleotides on the Alternate-Stranded Triple Helix, T. Moriguchi; A.T.M; Zafrul Azam; K. Shinozuka, 2011年, Bioconjugate Chemistry
- Investigation of the mechanism of the fluorescent emission of the silylated pyrene modified DNA, Tomohisa Moriguchi; Masayoshi Hattori; Tohru Sekiguchi; Kazuo Shinozuka, 2009年, Nucleic Acids Symp. Ser, 53, 31-32.
- Novel method of the synthesis and hybridization properties of an oligonucleotide containing non-ionic diisopropylsilyl internucleotide linkage, Moriguchi, Tomohisa; Sekine, Mitsuaki; Shinozuka, Kazuo, 2013年, BIOORGANIC & MEDICINAL CHEMISTRY, 21, 24, 8013, 8018
- Pseudo-dumbbell-type molecular beacon probes bearing modified deoxyuridine derivatives and a silylated pyrene as a fluorophore, Jakir Ahmed Chowdhury; Tomohisa Moriguchi; Kazuo Shinozuka, 2015年, Bulletin of the Chemical Society of Japan, 88, 3, 496, 502
- Development of a novel stem-loop-type molecular beacon probe possessing polyamine-connected deoxyuridine and silylated pyrene, Jakir Ahmed Chowdhury; Tomohisa Moriguchi; Kazuo Shinozuka, 2014年, Chemistry Letters, 43, 12, 1915, 1917
- Alternate stranded triplex formation of chimeric DNA composed of tandem a- and b-anomeric strands, Kazuo Shinozuka; Noritake Matsumoto; Hideo Suzuki; Tomohisa Moriguchi; Hiroaki Sawai, 2002年, J. Chem. Soc. Chem. Comm., 2712-13
- Total synthesis of agrocin 84 and phosmidosine as naturally occurring nucleotidic antibiotics having P-N bond linkages, Mitsuo Sekine; Tomohisa Moriguchi; Takeshi Wada; Kohji Seio, 2001年, Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 59, 11, 1109, 1120, 書評論文,書評,文献紹介等
- Modified a-b chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability, MORIGUCHI TOMOHISA; SHINOZUKA KAZUO, 2006年, Chemical Communications, pp 335-337
- Synthesis and properties of oligodeoxynucleotides having an N-phosphoryl group, MORIGUCHI TOMOHISA; 関根 光雄, 2003年, European Journal of Organic Chemistry, pp. 2260-67
- Synthesis of small multifunctional molecules having nucleic acid binding property, Kumiko Nakanuma; Tomohisa Moriguchi; Hideo Suzuki; Kazuo Shinozuka, 2001年, Nucleic Acids Research Supplement, 1, 69, 70
- Formation and stability of alternate-stranded triplex formed with alpha, beta-chimeric oligoDNA, Yoshihiro Hirose; Aimi Kadoya; Noritake Matsumoto; Takanori Miyashita; Tomohisa Moriguchi; Kazuo Shinozuka, 2002年, Nucleic Acids Research Supplement, 2, 263, 264
- Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis, Tomohisa Moriguchi; Tomoyuki Ohike; Kazuo Shinozuka, 2006年, Nucleic Acids Symposium Series, 50, 187, 188
- Investigation of antisense DNA having C-5 polyamine substituted 2’-deoxyuridine derivative, Hideaki Sakai; Tomohisa Moriguchi; Hideo Suzuki; Makoto Matsukura; Kazuo Shinozuka, 2001年, Nucleic Acids Research Supplement, 127, 128
- Investigation of the mechanism of the fluorescent emmision of the silylated pyrene-modified DNA., T. Moriguchi; M. Hattori; M. Sekiguchi; K. Shinozuka, 2009年, Nucleic Acids Res. Sym. Ser., 53, 31, 32
- Synthesis and Properties of Oligonucleotides Containing Silylated Pyrene Derivatives, T. Moriguchi; M. Hattori; T. Sekiguchi; M. Ichimura; K. Shinozuka, 2008年, Nucleid Acids Res. Symp. Ser.,, 52, 255, 256
- Synthesis and properties of novel oligodeoxynucleotides containing 6,3′-methanodeoxyuridine, Tomohisa Moriguchi; Fumisada Yamato; Kazuo Shinozuka, 2008年05月05日, Chemistry Letters, 37, 5, 548, 549
- Termini-free molecular beacon utilizing silylated perylene and anthraquinone attached to the C-5 position of pyrimidine nucleobase, Yuzuru Sato; Tomohisa Moriguchi; Kazuo Shinozuka, 2012年, Chemistry Letters, 41, 4, 420, 422
- Investigation of the mechanism of the fluorescent emission of the silylated pyrene modified DNA, Tomohisa Moriguchi; Masayoshi Hattori; Tohru Sekiguchi; Kazuo Shinozuka, 2009年, Nucleic Acids Symp. Ser, 53, 31-32.
講演・口頭発表等
- Synthesis and triplex forming ability of Novel α-β chimeric oligonucleotides having an intercalator moiety at the linker portion, Pacfichem2005, 2005年
- EDTA・Fe(II)-アントラキノン新規金属錯体の合成とその二重DNA切断活性に関する研究, 日本化学会第85春季年会, 2005年
- C-5トリスミアン修飾した2'-O-Methyluridine誘導体を含む新規ホスホロチオエートDNAの合成とその性質, 日本化学会第85回春期年会, 2005年
- mRNAを加水分解敵・配列特異的に切断する切断活性を持つアントラキノン誘導体を導入した新規修飾核酸の開発, 第15回アンチセンスシンポジウム, 2005年
- EDTA・Fe(II)-アントラキノン新規金属錯体の合成とそのDNA切断活性に関する研究, 第15回アンチセンスシンポジウム, 2005年
- 塩基部及び糖部固定型ヌクレオシドを含むオリゴDNAの合成と性質の比較, 日本化学会第84春季年会, 2004年
- 3'アミノアシルチミジン-5'-リン酸体の合成と、これを用いた核酸上でのペプチド結合形成反応の検討, 日本化学会第84春季年会, 2004年
- 高次構造を制御した新規人工RNA切断酵素の開発, 日本化学会第84春季年会, 2004年
- メチルシトシンを含むDNA二重鎖を識別するTFOの開発, 日本化学会第84春季年会, 2004年
- Synthesis and alternate-stranded triplex forming ability of novel alpha-beta chimeric oligonucleotides bearing an intercalator-conjugated nucleobase, 第31回核酸化学シンポジウム, 2004年
- ピリミジンギャップを含むポリピュリン配列に結合するアントラキノンを導入した新規三重鎖形成核酸の開発, 第14回アンチセンスシンポジウム, 2004年
- 新規蛍光消光解消型オリゴヌクレオチドプローブの合成、及びその二重鎖形成能と蛍光挙動, 日本化学会第83春季年会, 2003年
- N-3位ポリアミン修飾ヌクレオシドを導入したアンチセンス核酸によるRNA鎖の特異的切断効果について, 第13回アンチセンスシンポジウム, 2003年
- 糖部および塩基部を同時に固定化したヌクレオシドを含むDNAの合成と性質, 第45回有機合成化学協会関東支部シンポジウム, 2003年
- 末端、及び鎖中央部にアントラキノン誘導体を結合した修飾オリゴDNAの合成及びその二重鎖安定化効果, 日本化学会第83春季年会, 2003年
- 核酸結合部位を持つ金属錯体-インターカレータ分子の合成とその性質に関する研究, 日本化学会第81春季年会, 2002年
- α、β-キメラ型DNAの合成、及びこれを用いたトランスストランド型三重鎖DＮＡ形成, 日本化学会第81春季年会, 2002年
- ピリミジンN-3位に分岐状ポリアミンを導入した修飾DNAの合成、及び人工Rnaseとしての応用, 日本化学会第81春季年会, 2002年
- C-5位ポリアミン修飾デオキシウリジン誘導体を含むアンチセンスDNAに関する研究, 第28回核酸化学シンポジウム, 2001年
- Synthesis and alternated-stranded triplex forming ability of novel α-β chimeric oligoDNA bearing an anthraquinone conjugate with 2.2-bis(hydroxymethyl)propionic acid, 日本化学会第85春季年会, 2005年
- Synthesis and sequense specific alternate-stranded triplex forming ability of novel lapha-beta chimeric oligoDNA bearing a muti-conjugate of 2.2'-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine, 第15回アンチセンスシンポジウム, 2005年
- ピリミジン逆位を持つポリピュリン鎖と安定なDNA三重鎖を形成する新規TFOの開発, 日本化学会第84春季年会, 2004年
- ポリアミンで修飾されたデオキシウリジン、及びデオキシイノシン誘導体を併せ持つ新規アンチセンスDNAの合成とその性質, 第13回アンチセンスシンポジウム, 2003年
- α、β-キメラ型オリゴDNAを用いた交叉型三重鎖の形成とその安定性, 第29回核酸化学シンポジウム, 2002年
- 核酸結合能を持つ多機能性小分子の合成, 第28回核酸化学シンポジウム, 2001年
- 新規蛍光消光解消型の二重鎖形成能、及び蛍光挙動と、リンカーがこれらに及ぼす影響, 日本化学会第84春季年会, 2004年
- 5-メチルシトシンをDNA二重鎖を検出する新規オリゴDNAの開発, 第14回アンチセンスシンポジウム, 2004年
- Synthesis of novel TFOs bearing an abasic portion and their triplex forming ability with a DNA duplex containing a pyrimidine-gapped polypurine strand, 3rd Internationla Symposium on Nucleic Acids Chemistry, 2003年
- ポリアミンで修飾されたデオキシウリジン、及びデオキシイノシン誘導体を併せ持つ新規オリゴDNAの合成とその性質, 日本化学会第83春季年会, 2003年
- C-5位に直鎖ポリアミンを結合したデオキシウリジンを組み込んだアンチセンスDNAの研究, 日本化学会第81春季年会, 2002年
- ホスミドシンの全合成を指向したN-アシルリン酸アミド結合の構築反応に関する研究, 日本化学会第79春季年会, 2001年
- アルファ型プリンヌクレオシドの合成法の検討, 日本化学会第86春季年会, 2006年
- cap構造を特異的に認識する分子の開発, 日本化学会第86春季年会, 2006年
- 5'-側にα-DNA鎖を3'-側にβ-DNA鎖をもつキメラTFOの合成及びその三重鎖形成能, 日本化学会第86春季年会, 2006年
- 二重鎖に対する鎖交換能を持つ新規修飾オリゴDNAの研究, 日本化学会第86春季年会, 2006年
- 核酸の位置特異的切断能を持つ、新規なオリゴDNA・インターカレーター・金属錯体コンジュゲートの開発, 日本化学会第88春季年会, 2007年
- SNP検出を指向した双頭型ヌクレオシド類縁体を含むオリゴヌクレオチドの合成, 日本化学会第８６春季年会, 2006年
- 遺伝子検出を指向した分岐型DNA-PNA複合体の合成に関する研究, 第21回生体機能関連シンポジウム, 2006年
- Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis, 第33回核酸化学シンポジウム, 2006年
- ケイ素を導入した新規ピレン蛍光標識化剤の開発、及びオリゴ核酸への導入, 第16回アンチセンスシンポジウム, 2006年
- Preparation of Silylpyrene Derivatives and Their Application as Fluorescent Labeling Agent for Biological Molecules, 第2回ケイ素科学国際シンポジウム, 2006年
- 二重鎖に対する鎖交換能を持つ新規修飾オリゴDNA, 日本化学会第88春季年会, 2007年
- 新規シリル化ピレン誘導体の合成及びこれを用いた蛍光標識化核酸の開発, 日本化学会第88春季年会, 2007年
- 5位にピレンを導入したデオキシウリジン誘導体を含む新規蛍光プローブDNAの開発, 日本化学会第88春季年会, 2007年
- シリル基を導入した新規ピレン誘導体によるオリゴ核酸の蛍光標識化, 日本化学会第88春季年会, 2007年
- 2'-位にシリル化ピレンが導入された修飾DNAの合成と性質, 日本化学会第８9春期年会, 2009年
- シリル化ピレンを導入した蛍光性コレステロールアナログの開発, 2009年
- C-5ビスピレン修飾デオキシウリジンを含む新規蛍光DNAプローブの開発, 日本化学会第８９春期年会, 2009年
- 異なるリンカー長をもつピレンをC-5位に導入したデオキシウリジンを含む蛍光プローブの開発, 日本化学会第８８春期年会, 2008年
- 核酸蛍光標識化化合物としての、二つのシリル基を持った新規ピレン誘導体の開発, 日本化学会第８８春期年会, 2008年
- シリル化ピレンで蛍光標識化された人工DNAの合成と性質, 日本化学会第８８春期年会, 2008年
- シリル化ピレンで修飾されたオリゴヌクレオチドを用いた遺伝子解析法の開発, 第１８回アンチセンスシンポジウム, 2008年
- デオキシウリジンのC-5位にピレン誘導体をもつ修飾DNAの合成と性質, 2010年
- Sequence Selective Recognition of Silylated Perylene-Labeled Molecular Beacon Probes, 2012年
- ダンベル型構造を持つ消光剤フリーなモレキュラービーコン, 2012年
- 光反応基ベンゾフェノンを含む修飾DNAの合成と光クロスリンク反応の検討, 2012年
- Fluorescent Properties of the Dumbbell-formed Silylated Pyrene ModifiedOligonucleotides, 2011年
- クリックケミストリーを用いた鎖交換能をもつ新規分岐型DNAの合成, 日本化学会, 2010年
- 新規ビスピレン修飾デオキシウリジン誘導体を含むDNAの合成と性質, 2010年
- シリル基を導入したピレン誘導体の核酸塩基による蛍光消光, 2010年
- C5位シリル化ペリレン修飾デオキシウリジン配列中に導入したモレキュラービーコンプローブの開発, 2010年
- クリックケミストリーを用いた鎖交換能を有する新規分岐型DNAの合成, 2011年
- シリル化ペリレン修飾蛍光プローブの開発, 2011年
- 新規Nile Red 型蛍光標識化剤のDNAへの導入とその蛍光挙動, 2011年
- シリル化ピレンのエキシマー発光を利用した新規モレキュラービーコン型蛍光核酸プローブの開発, 2011年
- 二重鎖DNA切断活性を持つ新規機能性TFOの合成, 2011年
- 金属錯体部位とインターカレーター部位をもつ三重鎖形成核酸の合成と配列特異的DNA切断活性, 2012年
- 新規ナイルレッド誘導体の合成と、DNA蛍光標識化への応用, 2012年
- シリル化ピレン修飾ダンベル型の開発, 2012年
- シリル化ペリレンをもつATPアプタマーの合成とその蛍光特性, 2012年
- ジイソプロピル基を持つ新規シリル化ピレンの合成、及びこれを用いた蛍光標識化プローブDNAの開発, 2013年
- シリル化ピレン修飾ダンベル型モレキュラービーコンの開発, 2013年
- C-5位トリスアミン修飾ヌクレオシドを含む新規ダンベル型デコイ核酸の開発, 2013年
- ジイソプロピルシリル結合をもつ修飾DNAの合成と性質, 2013年
- Synthesis and triplex forming ability of Novel α-β chimeric oligonucleotides having an intercalator moiety at the linker portion, Pacfichem2005, 2005年
- Synthesis and alternate-stranded triplex forming ability of novel alpha-beta chimeric oligonucleotides bearing an intercalator-conjugated nucleobase, 第31回核酸化学シンポジウム, 2004年
- Synthesis and alternated-stranded triplex forming ability of novel α-β chimeric oligoDNA bearing an anthraquinone conjugate with 2.2-bis(hydroxymethyl)propionic acid, 日本化学会第85春季年会, 2005年
- Synthesis and sequense specific alternate-stranded triplex forming ability of novel lapha-beta chimeric oligoDNA bearing a muti-conjugate of 2.2'-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine, 第15回アンチセンスシンポジウム, 2005年
- Synthesis of novel TFOs bearing an abasic portion and their triplex forming ability with a DNA duplex containing a pyrimidine-gapped polypurine strand, 3rd Internationla Symposium on Nucleic Acids Chemistry, 2003年
- Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis, 2006年
- Preparation of Silylpyrene Derivatives and Their Application as Fluorescent Labeling Agent for Biological Molecules, 2006年
- Sequence Selective Recognition of Silylated Perylene-Labeled Molecular Beacon Probes, 2012年
- Fluorescent Properties of the Dumbbell-formed Silylated Pyrene ModifiedOligonucleotides, 2011年