研究者基本情報

研究者

• 氏名

  喜名　振一郎, キナ　シンイチロウ

所属

• 医学教育開発学分野, 講師

基本情報

• 研究者氏名（日本語）

  喜名, 振一郎

• 研究者氏名（カナ）

  キナ, シンイチロウ

所属

• 群馬大学, 大学院医学系研究科, 講師

所属部局等

• 所属情報

  大学院医学系研究科

学位

• 医学博士

経歴

• 群馬大学大学院医学系研究科, 講師, 准教授・常勤専任講師相当
• 琉球大学 医学研究科, 助教, 助教相当
• 2010年04月01日
• 2010年04月01日, - , 琉球大学 医学研究科 助教

研究活動情報

研究分野

• ライフサイエンス, 分子生物学

研究キーワード

• 活性酸素
• メトロノーム化学療法
• 組織学的分化度
• 炎症
• HPV
• 癌

論文

• Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy, Shinichiro Kina, Sho Miyamoto, Reika Kawabata-Iwakawa, Mika Kina-Tanada, Masaru Ogawa, Satoshi Yokoo, 2024年03月15日, Am J Cancer Res, 14, 3, 1033, 1051, 研究論文（学術雑誌）

  DOI
• Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis, Akiyuki Sugisawa, Zensei Toyoda, Yasuka Tanabe, Karina Uehara, Aya Oshiro, Reo Yamazato, Chiharu Sakamoto, Shohei Yogi, Kiyoto Kurima, Shinichiro Kina, Michiyo Sakiyama, Takao Kinjo, 2023年02月01日, Menopause, 30, 2, 193, 200, 研究論文（学術雑誌）

  DOI
• EphA4 signaling is involved in the phenotype of well-differentiated oral squamous cell carcinoma with decreased tumor immunity, Shinichiro Kina, Reika Kawabata-Iwakawa, Sho Miyamoto, Tomoki Kato, Mika Kina-Tanada, Akira Arasaki, 2023年02月18日, European Journal of Pharmacology, 945, 研究論文（学術雑誌）

  DOI
• Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage, Uehara K, Tanabe Y, Hirota S, Higa S, Toyoda Z, Kurima K, Kina S, Nakasone T, Arasaki A, Kinjo T., 2021年06月, BMC Cancer, 21, 1
• Synthesis and Binding Property of a Novel Tripodal Hexadentate Ligand Having Catechol Moieties, Minoru Hayashi,Kazuhisa Hiratani,Shin-Ichiro Kina,Megumi Ishii,Kazuhiko Saigo, 1998年06月, Tetrahedron Letter, Tetrahedron Letter, 39, 34, 6211, 6214
• Trinuclear copper(II) complex showing high selectivity for the hydrolysis of 2'-5' over 3'-5' for UpU and 3'-5' over 2'-5' for ApA ribonucleotides., Komiyama M,Kina S,Matsumura K,Sumaoka J,Tobey S,Lynch VM,Anslyn E, 2002年11月, J Am Chem Soc., J Am Chem Soc., 124, 46, 13731, 13736
• Anti-CD26 monoclonal antibody-mediated G(1)-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix, T Inamoto,T Yamochi,K Ohnuma,S Iwata,S Kina,S Inamoto,M Tachibana,Y Katsuoka,NH Dang,C Morimoto, 2006年06月, CLINICAL CANCER RESEARCH, 12, 11, 3470, 3477, 研究論文（学術雑誌）

  DOI
• Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1., Ohnuma K,Uchiyama M,Yamochi T,Nishibashi K,Hosono O,Takahashi N,Kina S,Tanaka H,Lin X,Dang NH,Morimoto C, 2007年03月, J Biol Chem., J Biol Chem., 282, 13, 10117, 10131
• Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors, Teruo Inamoto,Taketo Yamada,Kei Ohnuma,Shinichiro Kina,Nozomu Takahashi,Tadanori Yamochi,Sakiko Inamoto,Yoji Katsuoka,Osamu Hosono,Hirotoshi Tanaka,Nam H. Dang,Chikao Morimoto, 2007年07月, CLINICAL CANCER RESEARCH, 13, 14, 4191, 4200, 研究論文（学術雑誌）

  DOI
• Involvement of protein-tyrosine phosphatase PTPMEG in motor learning and cerebellar long-term depression, Shin-ichiro Kina,Tohru Tezuka,Shinji Kusakawa,Yasushi Kishimoto,Sho Kakizawa,Koichi Hashimoto,Miho Ohsugi,Yuji Kiyama,Reiko Horai,Katsuko Sudo,Shigeru Kakuta,Yoichiro Iwakura,Masamitsu Iino,Masanobu Kano,Toshiya Manabe,Tadashi Yamamoto, 2007年10月, EUROPEAN JOURNAL OF NEUROSCIENCE, 26, 8, 2269, 2278, 研究論文（学術雑誌）

  DOI
• Regulation of chemokine production via oxidative pathway in HeLa cells., Kina S,Nakasone T,Takemoto H,Matayoshi A,Makishi S,Sunagawa N,Liang F,Phonaphonh T,Sunakawa H, 2010年01月, Mediators Inflamm., Mediators Inflamm., 2009, 2009, doi: 10.1155/2009/183760.
• HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production, Takemoto\, Hiroyuki,Kina\, Shinichiro,Arakaki\, Keiichi,Matayoshi\, Akira,Liang\, Feixin,Phonaphonh\, Thongsavanh,Kuang\, Hai,Sunakawa\, Hajime, 2010年10月, Ryukyu Medical Journal, Ryukyu Medical Journal, 29, 3・4, 23, 30
• Evaluation of delayed cervical lymph node metastasis in T1/2 squamous cell carcinoma of the tongue, Matayoshi\, Akira,Nakasone\, Toshiyuki,Kina\, Shinichiro,Arakaki\, Keiichi,Takemoto\, Hiroyuki,Liang\, Feixin,Phonaphonh\, Thongsavanh,Kuang\, Hai,Sunakawa\, Hajime, 2010年12月, Ryukyu Medical Journal, Ryukyu Medical Journal, 29, 3・4, 31, 38
• HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells, Feixin Liang,Shinichiro Kina,Hiroyuki Takemoto,Akira Matayoshi,Thongsavanh Phonaphonh,Nao Sunagawa,Keiichi Arakaki,Akira Arasaki,Hai Kuang,Hajime Sunakawa, 2011年, MEDIATORS OF INFLAMMATION, 2011, 2011, doi: 10.1155/2011/263216., 研究論文（学術雑誌）

  DOI
• GABA/glycine signaling during degeneration and regeneration of mouse hypoglossal nerves., Tatetsu M,Kim J,Kina S,Sunakawa H,Takayama C, 2012年01月, Brain Res., Brain Res., 1446, 22, 33
• PDGF alpha receptor is a mediator for Cisplatin-induced Met expression, Kina S,Phonaphonh T,Liang F,Kuang H,Arasaki A,Arakaki K,Nakasone T,Sunakawa H, 2013年01月, Eur J Pharmacol., EUROPEAN JOURNAL OF PHARMACOLOGY, 699, 1-3, 227, 232, 研究論文（学術雑誌）

  DOI
• Impact of metronomic neoadjuvant chemotherapy on early tongue cancer, Shinichiro Kina,Toshiyuki Nakasone,Takao Kinjo,Tessho Maruyama,Toshihiro Kawano,Akira Arasaki, 2016年10月, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 78, 4, 833, 840, 研究論文（学術雑誌）

  DOI
• Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice, Mika Kina-Tanada,Mayuko Sakanashi,Akihide Tanimoto,Tadashi Kaname,Toshihiro Matsuzaki,Katsuhiko Noguchi,Taro Uchida,Junko Nakasone,Chisayo Kozuka,Masayoshi Ishida,Haruaki Kubota,Yuji Taira,Yuichi Totsuka,Shin-ichiro Kina,Hajime Sunakawa,Junichi Omura,Kimio Satoh,Hiroaki Shimokawa,Nobuyuki Yanagihara,Shiro Maeda,Yusuke Ohya,Masayuki Matsushita,Hiroaki Masuzaki,Akira Arasaki,Masato Tsutsui, 2017年06月, DIABETOLOGIA, 60, 6, 1138, 1151, 研究論文（学術雑誌）

  DOI
• Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line., Kina S,Kinjo T,Liang F,Nakasone T,Yamamoto H,Arasaki A, 2018年12月, Eur J Pharmacol., Eur J Pharmacol., 5, 840, 70, 78
• K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation., Tamanaha-Nakasone A,Uehara K,Tanabe Y,Ishikawa H,Yamakawa N,Toyoda Z,Kurima K,Kina S,Tsuneki M,Okubo Y,Yamaguchi S,Utsumi D,Takahashi K,Arakawa H,Arasaki A,Kinjo T, 2019年04月, Sci Rep., Sci Rep., 9, 1, 6416, doi: 10.1038/s41598-019-42763-
• Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma., Kina S,Nakasone T,Kinjo T,Nimura F,Sunagawa N,Arasaki A, 2019年06月, Clin Oral Investig., Clin Oral Investig., 23, 6, 2593, 2598
• Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor., Higa-Nakamine S,Okitsu-Sakurayama S,KIna S,Yamamoto H, 2020年01月, FEBS J
• A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates, Kina, Shinichiro; Kawabata-Iwakawa, Reika; Miyamoto, Sho; Arasaki, Akira; Sunakawa, Hajime; Kinjo, Takao, 2021年, Journal of Drug Targeting, in press
• Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line, Kina, Shinichiro;Kinjo, Takao;Liang, Feixin;Nakasone, Toshiyuki;Yamamoto, Hideyuki;Arasaki, Akira, 2018年, EUROPEAN JOURNAL OF PHARMACOLOGY, EUROPEAN JOURNAL OF PHARMACOLOGY, 840, 70, 78

  DOI
• K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation, Tamanaha-Nakasone, Ayumi;Uehara, Karina;Tanabe, Yasuka;Ishikawa, Haruna;Yamakawa, Natsuko;Toyoda, Zensei;Kurima, Kiyoto;Kina, Shinichiro;Tsuneki, Masayuki;Okubo, Yuko;Yamaguchi, Sayaka;Utsumi, Daisuke;Takahashi, Kenzo;Arakawa, Hirofumi;Arasaki, Akira;Kinjo, Takao, 2019年, SCIENTIFIC REPORTS, SCIENTIFIC REPORTS, 9

  DOI
• Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma, Kina, Shinichiro;Nakasone, Toshiyuki;Kinjo, Takao;Nimura, Fumikazu;Sunagawa, Nao;Arasaki, Akira, 2019年, CLINICAL ORAL INVESTIGATIONS, CLINICAL ORAL INVESTIGATIONS, 23, 6, 2593, 2598

  DOI
• Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor, Higa-Nakamine, Sayomi;Okitsu-Sakurayama, Shiho;Kina, Shinichiro;Yamamoto, Hideyuki, 2020年, FEBS JOURNAL, FEBS JOURNAL, 287, 16, 3551, 3564

  DOI
• A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates, Kina, Shinichiro;Kawabata-Iwakawa, Reika;Miyamoto, Sho;Arasaki, Akira;Sunakawa, Hajime;Kinjo, Takao, 2021年, JOURNAL OF DRUG TARGETING, JOURNAL OF DRUG TARGETING, 29, 10, 1118, 1127

  DOI
• Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage, Uehara, Karina;Tanabe, Yasuka;Hirota, Shintaro;Higa, Saki;Toyoda, Zensei;Kurima, Kiyoto;Kina, Shinichiro;Nakasone, Toshiyuki;Arasaki, Akira;Kinjo, Takao, 2021年, BMC CANCER, BMC CANCER, 21, 1

  DOI
• 早期舌扁平上皮癌患者に対してUFTおよびS-1を投与した術前化学療法, 喜名 振一郎;仁村 文和;金城 貴夫;砂川 奈穂;喜名 美香;新崎 章;仲宗根 敏幸, 2019年10月, 日本癌治療学会学術集会抄録集, 57回, P2
• パンデミック下の医学部初年次教育　リアルタイム型オンライン配信による自然科学演習・実験, 山本 華子;岸 美紀子;喜名 振一郎;鈴木 啓;關 麻衣;鎌田 英男;鯉淵 典之, 2021年07月, 医学教育, 52, Suppl., 145
• オンラインと対面を併用した医療面接実習の構築と感染対策の実際, 葭田 明弘;岸 美紀子;喜名 振一郎;鈴木 啓;齋藤 従道;藤平 和吉;鎌田 英男, 2021年07月, 医学教育, 52, Suppl., 152
• オンラインを活用した臨床実習前医療面接実習の実践, 齋藤 従道;藤平 和吉;岸 美紀子;葭田 明弘;喜名 振一郎;鈴木 啓;鎌田 英男, 2021年07月, 医学教育, 52, Suppl., 172
• Targeting EphA4 abrogates intrinsic resistance to chemotherapy in well-differentiated cervical cancer cell line., Kina Shinichiro;Kinjo Takao;Liang Feixin;Nakasone Toshiyuki;Yamamoto Hideyuki;Arasaki Akira, 2018年09月27日, European journal of pharmacology, European journal of pharmacology, 840

  DOI
• Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma., Kina Shinichiro;Nakasone Toshiyuki;Kinjo Takao;Nimura Fumikazu;Sunagawa Nao;Arasaki Akira, 2018年10月13日, Clinical oral investigations, Clinical oral investigations, 23, 6

  DOI
• K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation., Tamanaha-Nakasone Ayumi;Uehara Karina;Tanabe Yasuka;Ishikawa Haruna;Yamakawa Natsuko;Toyoda Zensei;Kurima Kiyoto;Kina Shinichiro;Tsuneki Masayuki;Okubo Yuko;Yamaguchi Sayaka;Utsumi Daisuke;Takahashi Kenzo;Arakawa Hirofumi;Arasaki Akira;Kinjo Takao, 2019年04月23日, Scientific reports, Scientific reports, 9, 1

  DOI
• A molecular signature of well-differentiated oral squamous cell carcinoma reveals a resistance mechanism to metronomic chemotherapy and novel therapeutic candidates., Kina Shinichiro;Kawabata-Iwakawa Reika;Miyamoto Sho;Arasaki Akira;Sunakawa Hajime;Kinjo Takao, 2021年05月27日, Journal of drug targeting, Journal of drug targeting, 29, 10

  DOI
• Co-expression of low-risk HPV E6/E7 and EBV LMP-1 leads to precancerous lesions by DNA damage., Uehara Karina;Tanabe Yasuka;Hirota Shintaro;Higa Saki;Toyoda Zensei;Kurima Kiyoto;Kina Shinichiro;Nakasone Toshiyuki;Arasaki Akira;Kinjo Takao, 2021年06月10日, BMC cancer, BMC cancer, 21, 1

  DOI
• Cytological characteristics of premalignant cervical epithelial lesions in postmenopausal women based on endocrine indices and parakeratosis, Sugisawa, Akiyuki;Toyoda, Zensei;Tanabe, Yasuka;Uehara, Karina;Oshiro, Aya;Yamazato, Reo;Sakamoto, Chiharu;Yogi, Shohei;Kurima, Kiyoto;Kina, Shinichiro;Sakiyama, Michiyo;Kinjo, Takao, 2023年, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 30, 2, 193, 200

  DOI

MISC

• 食事中のnitriteおよびnitrateの不足は代謝症候群、内皮機能不全、および心血管死を惹起する, 喜名 美香,坂梨 まゆ子,谷本 昭英,松崎 俊博,野口 克彦,仲宗根 淳子,下川 宏明,喜名 振一郎,砂川 元,大屋 祐輔,新崎 章,筒井 正人, 2017年01月, 血管, 40, 1, 60, 60
• Molecular Signature of Tumors with Monoallelic 13q14 Deletion: a Case Series of Spindle Cell Lipoma and Genetically-Related Tumors Demonstrating a Link Between FOXO1 Status and p38 MAPK Pathway, Karina Uehara,Fukino Ikehara,Ryo Shibuya,Iwao Nakazato,Mariko Oshiro,Masaya Kiyuna,Yasuka Tanabe,Zensei Toyoda,Kiyoto Kurima,Shinichiro Kina,Masanori Hisaoka,Takao Kinjo, 2018年10月01日, Pathology and Oncology Research, Pathology and Oncology Research, 24, 861, 869

  DOI

講演・口頭発表等

• 一年次学生の学修支援環境の新型コロナウイルス禍による変化, 医学教育学会, 2022年07月, 2022年07月
• 高分化型口腔扁平上皮癌が有するメトロノーム化学療法耐性機構の解明, 喜名振一郎, 宮本昇, 第４０回日本口腔腫瘍学会, 2022年02月, 2022年02月

共同研究・競争的資金等の研究課題

• Wnt 経路を介した組織学的分化度依存的に生じる腫瘍血管形成機構の解明, 喜名振一郎, 文部科学省, 科学研究費, 基盤研究(C), 群馬大学, 2024年, 2026年, 研究代表者
• 抗癌剤耐性高分化型口腔癌に対するEphA4を標的とした分子生学的メカニズムの解明, 仲宗根敏幸, 基盤研究(C), 2018年, 2020年, 競争的資金
• ＨＰＶ陽性腫瘍に対する効率的な分子標的薬投与の可能性について, 砂川 元, 基板研究(C), 2011年, 2013年, 競争的資金
• 癌治療後に誘起される後発転移活性化機構の解明, 喜名 振一郎, 若手研究(B), 2012年, 2014年, 研究代表者, 競争的資金
• 抗癌剤曝露依存的に活性化されるEphA4 を標的とした新規治療戦略の構築, 喜名 振一郎, 基盤研究(C), 2017年, 2019年, 研究代表者, 競争的資金