SAHEKI Toshihiko

Science and Engineering Education CenterAssociate Professor
Last Updated :2026/07/03

■Researcher basic information

Researcher

  • Name

    SAHEKI Toshihiko

Affiliation

  • Science and Engineering Education Center, Associate Professor

Profile and Settings

  • Name

    Saheki, Toshihiko

Foreign language

  • Use in presentation

    English
  • Use in publication

    English

Affiliation

  • Gunma University, Assistant of Professor, Assistant prof lv

Affiliation

  • 所属情報

    Graduate School of Science and Technology
  • Job title

    Assistant Professor, Assistant of Professor

Degree

  • Ph.D

Professional Memberships

  • JAPAN SOCIETY FOR SCIENCE EDUCATION, url
  • url
  • url
  • url
  • url
  • JAPAN SOCIETY FOR SCIENCE EDUCATION, url

Research History

  • 1991, 1992
  • 2005, 2007
  • Gunma University, Assistant Professor, Assistant prof lv

■Research activity information

Research Areas

  • Life sciences, Molecular biology
  • Life sciences, Cell biology
  • Life sciences, Functional biochemistry

Research Interests

  • Polyploid
  • Hepatocyte
  • Cytokinesis
  • Intermediate filaments
  • Cytoskeleton
  • signal transduction
  • proteomics
  • stem cell
  • regeneration
  • differentiation

Papers

  • STRUCTURE OF THE BOVINE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR (TYPE-C) GENE, T SAHEKI,T MIZUNO,T IWATA,Y SAITO,T NAGASAWA,KU MIZUNO,F ITO,T ITO,H HAGIWARA,S HIROSE, Jun. 1991, JOURNAL OF BIOLOGICAL CHEMISTRY, 266, 17, 11122, 11125, Scientific journal
  • OROTATE PHOSPHORIBOSYLTRANSFERASE FROM THERMUS-THERMOPHILUS - OVEREXPRESSION IN ESCHERICHIA-COLI, PURIFICATION AND CHARACTERIZATION, J BUNNAK,H HAMANA,Y OGINO,T SAHEKI,A YAMAGISHI,T OSHIMA,T DATE,T SHINOZAWA, Dec. 1995, JOURNAL OF BIOCHEMISTRY, 118, 6, 1261, 1267, Scientific journal
  • REGULATION FACTOR FOR PLANARIAN REGENERATION, T SHINOZAWA,S SHIOZAKI,M EZAKI,H FUJINO,T TANAKA,T SAHEKI, Jun. 1995, HYDROBIOLOGIA, 305, 1-3, 247, 253, Scientific journal
  • PHYSICAL AND FUNCTIONAL ASSOCIATION OF THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR WITH PARTICULATE GUANYLATE-CYCLASE AS DEMONSTRATED USING DETERGENT EXTRACTS OF BOVINE LUNG MEMBRANES, M ISHIDO,T FUJITA,H HAGIWARA,M SHIMONAKA,T SAHEKI,Y HIRATA,S HIROSE, Oct. 1986, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 140, 1, 101, 106, Scientific journal
  • IDENTIFICATION OF THE PRIMARY TRANSLATION PRODUCT OF ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR MESSENGER-RNA IN A CELL-FREE SYSTEM USING ANTIRECEPTOR ANTISERUM, K UCHIDA,M SHIMONAKA,T SAHEKI,T ITO,S HIROSE, Sep. 1987, JOURNAL OF BIOLOGICAL CHEMISTRY, 262, 26, 12401, 12402
  • INHIBITION OF ATRIAL NATRIURETIC PEPTIDE-INDUCED CYCLIC-GMP ACCUMULATION IN THE BOVINE ENDOTHELIAL-CELLS WITH ANTI-ATRIAL NATRIURETIC PEPTIDE RECEPTOR ANTISERUM, M ISHIDO,T FUJITA,M SHIMONAKA,T SAHEKI,S OHUCHI,T KUME,ISHIGAKI\, I,S HIROSE, Jan. 1989, JOURNAL OF BIOLOGICAL CHEMISTRY, 264, 1, 641, 645, Scientific journal
  • IMMUNOCHEMICAL AND BIOCHEMICAL DISTINCTION OF SUBTYPES OF ATRIAL NATRIURETIC PEPTIDE RECEPTOR, T SAHEKI,M SHIMONAKA,K UCHIDA,T MIZUNO,S HIROSE, Oct. 1989, JOURNAL OF BIOCHEMISTRY, 106, 4, 627, 632, Scientific journal
  • PRIMARY STRUCTURE OF THE HUMAN ELAFIN PRECURSOR PREPROELAFIN DEDUCED FROM THE NUCLEOTIDE-SEQUENCE OF ITS GENE AND THE PRESENCE OF UNIQUE REPETITIVE SEQUENCES IN THE PROSEGMENT, T SAHEKI,F ITO,H HAGIWARA,Y SAITO,J KUROKI,S TACHIBANA,S HIROSE, May 1992, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 185, 1, 240, 245, Scientific journal
  • 1989, 7, 461, 466
  • 2008, 7, 4, 9, 12
  • Triple Helical Conformation in Aqueous Solutions of β-1,3-D-Glucans with Varyling the Degree of Branching by the Smigh Degradation, Yoshiba Kazuto,Saheki Toshihiko,Christensen Gjorn E,Dobashi Toshiaki, 2019, ACS Applied Bio Materials
  • 細胞の運命を操るために, 佐伯俊彦, 2006, 科技振セミナー講演集
  • Carcinogen adsorbent prepared from DNA complex by gamma-ray irradiation, 2008, Journal of Biomaterials Science: Polymer Edition
  • 2004, 3, 4, 13, 14
  • 1992, 8, 258, 263
  • Induction of PC12 Cell Death, Apoptosis, by a Sialoglycopeptide from Bovine Brain., Kobayashi\, Y,Saheki\, T,Shinozawa\, T, 1994, Biochem. Biophys. Res. Commun., 203, 1554, 1559
  • Visualization of ANP Receptor on Glomeruli of Bovine Kidney by Use of a Specific Antiserum., Shimonaka\, M,Saheki\, T,Hagiwara\, H,Hagiwara\, Y,Sono\, H,Hirose\, S, 1987, Am. J. Physiol., 253, F1058, F1062
  • Purification of Atrial Natriuretic Peptide Receptor from Bovine Lung., Shimonaka\, M,Saheki\, T,Hagiwara\, H,Ishido\, M,Nogi\, A,Fujita\, T,Wakita\, K,Inada\, Y,Kondo\, J,Hirose\, S, 1987, J. Biol. Chem., 262, 12, 5510, 5514
  • Miniaturized two-dimensional gel electrophoresis of high-molecular-weight proteins using low-concentration multifilament-supporting gel for isoelectric focusing, ODAKE Tamao;SAHEKI Toshihiko;KAMEZAWA Kazutoshi;MIYATA Kozue;TAKIGUCHI Hiromi;HOTTA Hiroki;ONDA Koki;KOJIMA Yasuaki;LI Jinxiang;TSUNODA Kin-ichi, Dec. 2009, Journal of Electrophoresis, 53, 4, 57, 61
  • The Student Exchange Program Between Gunma University and New York State University at Stony Brock, SAHEKI Toshihiko, 2015, Journal of JSEE, 63, 5, 5_117, 5_121
  • Fast separation of large proteins with two-dimensional gel electrophoresis using a low-concentration polyacrylamide gel supported by a loose multifilament string, Saheki Toshihiko;Odake Tamao;Kojima Yasuaki;Tsunoda Kin-ichi, 2005, Abstracts for Annual Meeting of Japanese Proteomics Society, 2005, 0, 95, 95
  • Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation., Saheki Toshihiko;Ito Hitomi;Sekiguchi Akihiro;Nishina Atsuyoshi;Sugiyama Toshihiro;Izumi Takashi;Kojima Itaru, 15 Jan. 2008, Cytotechnology, 57, 2
  • A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test., Enomoto Rina;Kurosawa Aya;Nikaido Yoshiaki;Mashiko Misaki;Saheki Toshihiko;Nakajima Nozomi;Kuroiwa Satoshi;Otobe Michinari;Ohsaki Maki;Tooyama Kazuya;Inoue Yusuke;Kuwabara Nobuo;Kikuchi Osamu;Kitamura Tadahiro;Kojima Itaru;Nakagawa Yuko;Saito Tamio;Osada Hiroyuki;Futahashi Mizuko;Sezutsu Hideki;Takeda Shigeki, 17 Aug. 2017, European journal of pharmacology, 814
  • Conformation and cooperative order-disorder transition in aqueous solutions of β-1,3-d-glucan with different degree of branching varied by the Smith degradation., Yoshiba Kazuto;Saheki Toshihiko;Christensen Bjørn E;Dobashi Toshiaki, 10 Jun. 2019, Biopolymers, 110, 9
  • ;, Nov. 2022, 95回, 2P

Misc.

  • Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation, Toshihiko Saheki,Hitomi Ito,Akihiro Sekiguchi,Atsuyoshi Nishina,Toshihiro Sugiyama,Takashi Izumi,Itaru Kojima, Jun. 2008, CYTOTECHNOLOGY, 57, 2, 137, 143
  • A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137
  • Miniaturized two-dimensional gel electrophoresis of high-molecular-weight proteins using low-concentration multifilament-supporting gel for isoelectric focusing, Odake T,Saheki T,Kamezawa K,Miyata K,Takiguchi H,Hotta H,Onda K,Kojima Y,Li J,Tsunoda K, 2010, J. Electrophoresis, 53, 57, 61
  • Study of butyrate signal transduction pathways in rat hepatic stem-like cells, Saheki T,Mukai Y,Saito K,Tajima E,Katakura K,Nishina A,Kishi M,Izumi T,Sugiyama T,Kojima I, 2009, Animal Cell Technol.: Basic & Applied Aspects, Proceedings of the 21st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT), 16
  • Genomic and proteomic characterization of the large Myoviridae bacteriophage: PHAGE TMA of the extreme thermophile Thermus thermophilus., Tamakoshi M,Murakami A,Tsuneizumi K,Sugisawa M,Kodama M,Takeda S,Saheki T,Izumi T,Akiba T,Mitsuoka K,Toh H,Yamashita A,Arisaka F,Hattori M,Oshima T,Yamagishi A, 2011, 1, 152, 164
  • Additive Effects of Betains on the Fibrinogen cryogelation Induced by Low Temperature, Y. Toyama,K. Miyamoto,K. Kubota,K. Wakamatsu,N. Nameki,T. Saheki,M. Ochiai, 2011, Transactions of the Materials Research Society of Japan, 36, 3, 393, 396
  • 2010, 53, 57, 61
  • 2009, 16
  • 2011, 1, 152, 164
  • 2015, 63, 5, 117, 121
  • 2014, 14, 1, 29, 32

Books and Other publications

  • Leap to the Future! 1 (2022), Contributor, Mutsumi Iijima, Are you not Good at English?, 31 Mar. 2021, 124, 60-63, Textbook
  • Leap to the Future! 2 (2022), Contributor, Mutsumi Iijima, Are you not Good at English?, 31 Mar. 2021, 124, 60-63, Textbook

Presentations

  • Insulin restores decreased p53 mRNA expression during polynucleated cells induction using a histone deacetylase inhibitor, Haruka Kimura, Toshihiko Saheki, The 95th Annual Meeting of the Japanease Biochemical Society, 10 Nov. 2022, 09 Nov. 2022, 11 Nov. 2022
  • Insulin affects p21 expression to promote polynuclear rat hepatic stem-like cell induction by histone deacetylase inhibitor, Toshihiko Saheki, Haruka Kimura, The 74th Annual Meeting of the Japan Society for Cell Biology, 28 Jun. 2022, 28 Jun. 2022, 30 Jun. 2022
  • 04 Dec. 2021, 04 Dec. 2021, 04 Dec. 2021, Japanese, Japan, Domestic conference
  • 20 Sep. 2019, English, Domestic conference
  • 24 Jun. 2019, English, Domestic conference
  • Acquisition of multiple nuclei by sodium butyrate treatment of rat hepatic stem-like cells, The Molecular Biology Society of Japan, 2011
  • Proteomic analysis of polyploid cells derived from rat hepatic stem-like cells, The Japanese Biochemical Society, 2013
  • Analysis of histone H3 acetylation in rat hepatic stem-like cells during multiple nucleation, Japanese Association for Animal Cell Technology, 2012
  • 2009
  • 2009
  • 2009
  • 2010
  • 2011
  • 2011
  • 2012
  • 2012
  • 2013
  • 2013
  • 2014
  • 2015
  • 2015
  • 2014
  • 2017
  • 2012
  • 09 Jun. 2020, 09 Jun. 2020, 11 Jun. 2020, English, Domestic conference
  • 07 Dec. 2019, 07 Dec. 2019, 07 Dec. 2019, Japanese, Japan, Domestic conference
  • 07 Dec. 2019, 07 Dec. 2019, 07 Dec. 2019, Japanese, Japan, Domestic conference

Research Grants and Projects

  • 20211207, 20220331

■Information on Social Contribution Activities

Social Activities

  • 2508, Jun. 2508
  • 23 Oct. 2024, 23 Oct. 2024, Others, Yes, Yes, Yes, Yes
  • 20 Aug. 2024, 21 Aug. 2024, Seminar, Yes
  • 21 Sep. 2020, 22 Sep. 2020, Seminar, Yes
  • 2018, Research advise, Yes
  • 2019, Research advise, Yes
  • 2020, Research advise, Yes
  • 2021, Research advise, Yes
  • 21 Sep. 2019, 22 Sep. 2019, Seminar, Yes
  • 22 Nov. 2020, 22 Nov. 2020, Seminar, Yes
  • 22 Aug. 2022, 23 Aug. 2020, Seminar, Yes
  • 09 Oct. 2022, 10 Oct. 2020, Seminar, Yes
  • 22 Aug. 2023, 23 Aug. 2023, Seminar, Yes
  • 22 Sep. 2023, 22 Sep. 2023, Seminar, Yes
  • 19 Aug. 2025, 20 Aug. 2025, Seminar, Yes
  • 13 Sep. 2025, 14 Sep. 2025, Seminar, Yes