Satsu Hideo

Division of Materials and Environment（Department of Food Science and Engineering）Professor
Last Updated :2026/07/04

■Researcher basic information

Researcher

  • Name

    Satsu Hideo

Profile and Settings

  • Name

    HIDEO, SATSU

Affiliation

  • Gunma University, Graduate School of Science and Technology Department of Materials and Bioscience, Professor, Prof lv

Research History

  • Apr. 2014, Mar. 2025, Maebashi Institute of Technology, Graduate school of Engineering Department of Environment and Life Engineering, Associate Professor, Associate prof lecturer lv
  • Apr. 2014, Mar. 2025, Maebashi Institute of Technology, Faculty of Engineering Department of Biotechnology, Associate Professor, Associate prof lecturer lv
  • Apr. 2014, Mar. 2025, Maebashi Institute of Technology, Graduate school of Engineering Division of Biotechnology, Associate Professor, Associate prof lecturer lv
  • Apr. 2007, Mar. 2014, The University of Tokyo, Graduate School of Agricultural and Life Sciences, Applied Biological Chemistry, Assistant prof lv
  • Aug. 2000, Mar. 2007, The University of Tokyo, Graduate School of Agricultural and Life Sciences, Applied Biological Chemistry, Others
  • Jan. 2000, Jul. 2000, Researcher postdoc lv
  • Jan. 2000, Jul. 2000
  • Apr. 1999, Dec. 1999, Researcher postdoc lv
  • Apr. 1999, Dec. 1999

■Research activity information

Research Areas

  • Life sciences, Food sciences

Papers

  • Promotion of ABCG2 gene expression by neolignans from Piper longum L, Nishina A; Ukiya M; Motegi K; Kiryu R; Sato D; Sada M; Hori Y; Satsu H; Uemura K; Koketsu M; Ninomiya M; Myint LMM; Kimura H, Sep. 2023, Biosci Biotechnol Biochem, 87, 12, 1523, 1531, Scientific journal
    DOI
  • Physiological effects of food ingredients on intestinal epithelial cell function., Satsu; H.; Kimura; S.; Hori; Y., Jun. 2023, Drug Metab Pharmacokinet., 50, 100499, Scientific journal
  • Signaling Pathway of Taurine-Induced Upregulation of TXNIP, Satsu; H.; Gondo; Y.; Shimanaka; H.; Imae; M.; Murakami; S.; Watari; K.; Wakabayashi; S.; Park; S.J.; Nakai; K.; Shimizu; M., Jul. 2022, Metabolites, 12, 7, 636, Scientific journal
  • Inhibitory Effect of Tangeretin and Cardamonin on Human Intestinal SGLT1 Activity In Vitro and Blood Glucose Levels in Mice In Vivo, Satsu; H.; Shibata; R.; Suzuki; H.; Kimura; S.; Shimizu; M., Sep. 2021, Nutrients, 13, 10, 3382, Scientific journal
  • Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease (NAFLD) Model System, Ukiya M; Motegi K; Sato D; Kimura H; Satsu H; Koketsu M; Ninomiya M; Myint LM; Nishina A., Jul. 2021, Chem. Biodivers., 18, 7, e2100243, Scientific journal
    DOI
  • Dipeptidyl Peptidase-IV Inhibitory Activity of Katsuobushi-Derived Peptides in Caco-2 Cell Assay and Oral Glucose Tolerance Test in ICR Mice, E. Seki; A. Yamamoto; Y. Fujiwara; T. Yamane; H. Satsu; I. Ohkubo, Jun. 2020, J. Agric. Food Chem., 68, 23, 6355, 6367, Scientific journal
    DOI
  • Regulation of detoxification enzymes by food components in intestinal epithelial cells, Satsu; H., 2019, Food Sci. Technol. Res., 25, 2, 149, 156, Scientific journal
    DOI
  • Effect of taurine on cell function via TXNIP induction in Caco-2 cells, Satsu; H.; Gondo; Y.; Shimanaka; H.; Watari; K.; Fukumura; M.; Shimizu; M., 2019, Adv. Exp. Med. Biol., 1155, 163, 172, Scientific journal
    DOI
  • Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in vitro., Gao; S.; Satsu; H.; Makino; T., Mar. 2018, J. Nat. Med., 72, 2, 530, 536, Scientific journal
    DOI
  • Suppressive effect of nobiletin and epicatechin gallate on fructose uptake in human intestinal epithelial Caco-2 cells, Hideo Satsu; Sohei Awara; Tomonori Unno; Makoto Shimizu, 2018, Bioscience, Biotechnology and Biochemistry, 82, 4, 636, 646, Scientific journal
    DOI
  • Molecular and cellular studies on the absorption, function, and safety of food components in intestinal epithelial cells, Hideo Satsu, Mar. 2017, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81, 3, 419, 425, Scientific journal
    DOI
  • Catechol groups enable reactive oxygen species scavenging-mediated suppression of PKD-NFkappaB-IL-8 signaling pathway by chlorogenic and caffeic acids in human intestinal cells, Hee Soon Shin; Hideo Satsu; Min-Jung Bae; Mamoru Totsuka; Makoto Shimizu, 2017, Nutrients, 9, 2, E165, Scientific journal
    DOI
  • Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People, Tatsuhiro Hisatsune; Jun Kaneko; Hiroki Kurashige; Yuan Cao; Hideo Satsu; Mamoru Totsuka; Yoshinori Katakura; Etsuko Imabayashi; Hiroshi Matsuda, 2016, JOURNAL OF ALZHEIMERS DISEASE, 50, 1, 149, 159, Scientific journal
    DOI
  • Establishment of a stable aryl hydrocarbon receptor-responsive HepG2 cell line, Hideo Satsu; Kazutaka Yoshida; Ayano Mikubo; Haru Ogiwara; Takahiro Inakuma; Makoto Shimizu, Aug. 2015, CYTOTECHNOLOGY, 67, 4, 621, 632, Scientific journal
    DOI
  • Anti-inflammatory effect of chlorogenic acid on the IL-8 production in Caco-2 cells and the dextran sulphate sodium-induced colitis symptoms in C57BL/6 mice, Hee Soon Shin; Hideo Satsu; Min-Jung Bae; Zhaohui Zhao; Haru Ogiwara; Mamoru Totsuka; Makoto Shimizu, Feb. 2015, FOOD CHEMISTRY, 168, 167, 175, Scientific journal
    DOI
  • Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin, Phuong Le Vu; Ryo Takatori; Taku Iwamoto; Yutaka Akagi; Hideo Satsu; Mamoru Totsuka; Kazuhiro Chida; Kenji Sato; Makoto Shimizu, 2015, SKIN PHARMACOLOGY AND PHYSIOLOGY, 28, 5, 227, 235, Scientific journal
    DOI
  • 6-Shogaol, a Major Compound in Ginger, Induces Aryl Hydrocarbon Receptor-Mediated Transcriptional Activity and Gene Expression, Kazutaka Yoshida; Hideo Satsu; Ayano Mikubo; Haru Ogiwara; Takafumi Yakabe; Takahiro Inakuma; Makoto Shimizu, Jun. 2014, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62, 24, 5492, 5499, Scientific journal
    DOI
  • Branched-chain amino acids inhibit the TGF-beta-induced down-regulation of taurine biosynthetic enzyme cysteine dioxygenase in HepG2 cells, Asami Hagiwara; Sonoko Ishizaki; Kenji Takehana; Shoji Fujitani; Ichiro Sonaka; Hideo Satsu; Makoto Shimizu, May 2014, AMINO ACIDS, 46, 5, 1275, 1283, Scientific journal
    DOI
  • Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells, Yuto Hiura; Hideo Satsu; Mika Hamada; Makoto Shimizu, May 2014, BIOFACTORS, 40, 3, 336, 345, Scientific journal
    DOI
  • Effects of Oral Administration of Glucosylceramide on Gene Expression Changes in Hairless Mouse Skin: Comparison between Whole Skin, Epidermis, and Dermis., Takatori; R*.; Le Vu Phuong*; Iwamoto; T.; Satsu; H.; Totsuka; M.; Chida; K.; Shimizu; M.; (*equal contribution), 2013, Biosci. Biotechnol. Biochem., 77, 9, 1882, 1887, Scientific journal
    DOI
  • A sphingosine 1-phosphate receptor 2 selective allosteric agonist., Satsu; H.; Schaeffer; M.T.; Guerrero; M.; Saldana; A.; Eberhart; C.; Hodder; P.; Cayanan; C.; Schürer; S.; Bhatarai; B.; Roberts; E.; Rosen; H.; Brown; S.J., 2013, Bioorg. Med. Chem., 21, 17, 5373, 5382, Scientific journal
  • In Vivo and in Vitro Studies on the Absorption Characteristics of beta-Cryptoxanthin in the Intestine, Naoki Takaishi; Hideo Satsu; Katsuhiko Takayanagi; Katsuyuki Mukai; Makoto Shimizu, Nov. 2012, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76, 11, 2124, 2128, Scientific journal
    DOI
  • Induction of NAD(P)H:quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells, Hideo Satsu; Emi Chidachi; Yuto Hiura; Haru Ogiwara; Yusuke Gondo; Makoto Shimizu, Oct. 2012, AMINO ACIDS, 43, 4, 1547, 1555, Scientific journal
    DOI
  • Effect of taurine on mRNA expression of thioredoxin interacting protein in Caco-2 cells, Yusuke Gondo; Hideo Satsu; Yoko Ishimoto; Taku Iwamoto; Makoto Shimizu, Sep. 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 426, 3, 433, 437, Scientific journal
    DOI
  • Dietary Flavonoid Naringenin induces Regulatory T cells via an Aryl Hydrocarbon Receptor (AhR)-mediated pathway., Wang; H.K. Yeh; C.H.; Iwamoto; T.; Satsu; H.; Shimizu; M.; Totsuka; M., 2012, J. Agric. Food Chem., 60, 9, 2071, 2178, Scientific journal
    DOI
  • Synergistic Effect of Tumor Necrosis Factor-Alpha and Hydrogen Peroxide on the Induction of IL-8 Production in Human Intestinal Caco-2 Cells, Hee Soon Shin; Zhaohui Zhao; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Oct. 2011, INFLAMMATION, 34, 5, 440, 447, Scientific journal
    DOI
  • IEX-1 suppresses apoptotic damage in human intestinal epithelial Caco-2 cells induced by co-culturing with macrophage-like THP-1 cells, Yoko Ishimoto; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Oct. 2011, BIOSCIENCE REPORTS, 31, 5, 345, 351, Scientific journal
    DOI
  • Effects of Chondroitin Sulfate and Its Oligosaccharides on Toll-Like Receptor-Mediated IL-6 Secretion by Macrophage-Like J774.1 Cells, Miao Jin; Taku Iwamoto; Kiyoshi Yamada; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Jul. 2011, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 75, 7, 1283, 1289, Scientific journal
    DOI
  • Metabolites of Galangin by 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Inducible Cytochrome P450 1A1 in Human Intestinal Epithelial Caco-2 Cells and Their Antagonistic Activity toward Aryl Hydrocarbon Receptor, Mika Hamada; Hideo Satsu; Hitoshi Ashida; Yoshiko Sugita-Konishi; Makoto Shimizu, Jul. 2010, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58, 13, 8111, 8118, Scientific journal
    DOI
  • Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells, Miao Jin; Taku Iwamoto; Kiyoshi Yamada; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Jul. 2010, CYTOKINE, 51, 1, 53, 59, Scientific journal
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  • Permeation of Disaccharides Derived from Chondroitin Sulfate through Human Intestinal Caco-2 Cell Monolayers via the Paracellular Pathway, Miao Jin; Hideo Satsu; Kiyoshi Yamada; Nozomi Hisada; Mamoru Totsuka; Makoto Shimizu, Jun. 2010, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74, 6, 1243, 1249, Scientific journal
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  • Transient Up-Regulation of Immunity- and Apoptosis-Related Genes in Caco-2 Cells Cocultured with THP-1 Cells Evaluated by DNA Microarray Analysis, Yoko Ishimoto; Yuji Nakai; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Feb. 2010, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74, 2, 437, 439, Scientific journal
    DOI
  • In Vitro Analysis of the Interaction Between Human Intestinal Epithelial Cells and Macrophage-Like Cells, Yoko Ishimoto; Hideo Satsu; Tetsunosuke Mochizuki; Mamoru Totsuka; Makoto Shimizu, 2010, ANIMAL CELL TECHNOLOGY: BASICS & APPLIED ASPECTS, 16, 231, 236, International conference proceedings
    DOI
  • Transepithelial Transport of Macromolecular Substances in IL-4 Treated Human Intestinal T84 Cell Monolayers, Tetsunosuke Mochizuki; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, Nov. 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73, 11, 2422, 2426, Scientific journal
    DOI
  • Suppressive Effect of an Isoflavone Fraction on Tumor Necrosis Factor-alpha-Induced Interleukin-8 Production in Human Intestinal Epithelial Caco-2 Cells, Hideo Satsu; Ja Shil Hyun; Hee Soon Shin; Makoto Shimizu, Oct. 2009, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 55, 5, 442, 446, Scientific journal
  • Inhibition of P-Glycoprotein Enhances the Suppressive Effect of Kaempferol on Transformation of the Aryl Hydrocarbon Receptor, Rie Mukai; Hideo Satsu; Makoto Shimizu; Hitoshi Ashida, Jul. 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73, 7, 1635, 1639, Scientific journal
    DOI
  • Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells, Yayoi Natsume; Shinya Ito; Hideo Satsu; Makoto Shimizu, Apr. 2009, TOXICOLOGY, 258, 2-3, 164, 175, Scientific journal
    DOI
  • Cycloheximide Treatment Induces the Uptake of Neutral and Dibasic Amino Acids via the Activation of System b(0,+) in Human Intestinal Caco-2 Cells, Hideo Satsu; Ja Shil Hyun; Hee Soon Shin; Makoto Shimizu, Feb. 2009, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 55, 1, 44, 51, Scientific journal
  • The effect of quercetin on the gene expression profile at mouse intestine., Natsume; Y.; Kadota; K.; Satsu; H.; Shimizu; M., 2009, Biosci. Biotechnol. Biochem., 73, 3, 722, 725, Scientific journal
    DOI
  • Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells, Yuri Kusano; Shunsuke Horie; Takahiro Shibata; Hideo Satsu; Makoto Shimizu; Eri Hitomi; Motohiro Nishida; Hitoshi Kurose; Ken Itoh; Akira Kobayashi; Masayuki Yamamoto; Koji Uchida, Jun. 2008, BIOCHEMISTRY, 47, 23, 6169, 6177, Scientific journal
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  • Attenuation by dietary taurine of dextran sulfate sodium-induced colitis in mice and of THP-1-induced damage to intestinal Caco-2 cell monolayers, Z. Zhao; H. Satsu; M. Fujisawa; M. Hori; Y. Ishimoto; M. Totsuka; A. Nambu; S. Kakuta; H. Ozaki; M. Shimizu, Jun. 2008, AMINO ACIDS, 35, 1, 217, 224, Scientific journal
    DOI
  • Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation, Dong Ok Son; Hideo Satsu; Yoshinobu Kiso; Mamoru Totsuka; Makoto Shimizu, May 2008, CYTOKINE, 42, 2, 265, 276, Scientific journal
  • 5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha-induced secretion of interleukin-8 from caco-2 cells, Zhaohui Zhao; Hee Soon Shin; Hideo Satsu; Mamoru Totsuka; Makoto Shimizu, May 2008, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 10, 3863, 3868, Scientific journal
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  • Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway, Nozomi Hisada; Hideo Satsu; Akira Mori; Mamoru Totsuka; Jun-ichi Kamei; Takashi Nozawa; Makoto Shimizu, Apr. 2008, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 72, 4, 1111, 1114, Scientific journal
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  • Producibility and digestibility of antihypertensive beta-casein tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in the gastrointestinal tract: Analyses using an in vitro model of mammalian gastrointestinal digestion, Kazuhito Ohsawa; Hideo Satsu; Kohj Ohki; Masashi Enjoh; Toshiaki Takano; Makoto Shimizu, Feb. 2008, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56, 3, 854, 858, Scientific journal
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  • The modulating effects of chondroitin sulphate A and its oligosaccharides on a macrophage-like cell line J774.1., Jin; M.; Yamada; K.; Satsu; H.; Hisada; N.; Totsuka; M.; Shimizu; M., 2008, J. Clin. Biochem. Nutr., 43, 1, 370, 373, International conference proceedings
  • Inhibitory effect of lactoperoxidase on the secretion of proinflammatory cytokine IL-8 in human intestinal epithelial Caco-2 cells., Matsushita; A.; Son; DO.; Satsu; H.; Takano; Y.; Kawakami; H.; Totsuka; M.; Shimizu; M., 2008, Int. Dairy J., 18, 9, 932, 938, Scientific journal
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  • Carnosine inhibits Interleukin-8 production via the suppression of eIF4E phosphorylation in the intestinal epithelial cells., Son; D.O.; Satsu; H.; Totsuka.; M.; Shimizu; M., 2008, J. Clin. Biochem. Nutr., 43, 1, 351, 354, International conference proceedings
  • Activation of the Pregnane X Receptor and Induction of MDR1 by Dietary Phytochemicals., Satsu; H.; Hiura; Y.; Mochizuki; K.; Hamada; M.; Shimizu; M., 2008, J. Agric. Food Chem., 56, 13, 5366, 5373, Scientific journal
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  • Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers, Naoki Takaishi; Kazutaka Yoshida; Hideo Satsu; Makoto Shimizu, Jun. 2007, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 55, 13, 5253, 5259, Scientific journal
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  • Modulation of the intestinal Ca2+ uptake by a cheese whey protein digest, Yoshihiko Takano; Toshiki Matsuura; Yukako Yoshikawa; Hideo Satsu; Ryuichiro Sato; Makoto Shimizu, Jun. 2007, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 71, 6, 1487, 1493, Scientific journal
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  • Cadmium induces Interleukin-8 production via NF-kappa B activation in the human intestinal epithelial cell, Caco-2, Ja Shil Hyun; Hideo Satsu; Makoto Shimizu, Jan. 2007, CYTOKINE, 37, 1, 26, 34, Scientific journal
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  • Induction by activated macrophage-like THP-1 cells of apoptotic and necrotic cell death in intestinal epithelial Caco-2 monolayers via tumor necrosis factor-alpha, Hideo Satsu; Yoko Ishimoto; Tomoko Nakano; Tetsunosuke Mochizuki; Toshihiko Iwanaga; Makoto Shimizu, Nov. 2006, EXPERIMENTAL CELL RESEARCH, 312, 19, 3909, 3919, Scientific journal
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  • Enhanced daunomycin accumulation in human intestinal Caco-2 cells from non-ionic food emulsifiers unrelated to the P-glycoprotein inhibitory mechanism, Naoki Takaishi; Hideo Satsu; Makoto Shimizu, Nov. 2006, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 70, 11, 2703, 2711, Scientific journal
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  • Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated by the over-expression of tissue macrophage inflammatory protein-2 mRNA, ZH Zhao; JS Hyun; H Satsu; S Kakuta; M Shimizu, Jul. 2006, TOXICOLOGY LETTERS, 164, 2, 144, 154, Scientific journal
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  • TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeated the human intestinal Caco-2 cell monolayers., Hamada; M.; Satsu; H.; Natsume; Y.; Nishiumi; S.; Fukuda; I.; Ashida; H.; Shimizu; M., 2006, J. Agric. Food Chem., 54, 23, 8891, 8898, Scientific journal
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  • Food factors that regulate intestinal inflammation: Evaluation of the factors by using a coculture system, Hideo Satsu; Makoto Shimizu, 2006, ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 14, 29, +, International conference proceedings
  • Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells, DO Son; H Satsu; M Shimizu, Aug. 2005, FEBS LETTERS, 579, 21, 4671, 4677, Scientific journal
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  • Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells, T Mochizuki; H Satsu; M Shimizu, Jun. 2005, FEBS LETTERS, 579, 14, 3069, 3074, Scientific journal
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  • In vitro system for assessing dioxin absorption by intestinal epithelial cells and for preventing this absorption by food substances, Y Natsume; H Satsu; M Hamada; K Kitamura; N Okamoto; M Shimizu, Jan. 2005, CYTOTECHNOLOGY, 47, 1-3, 79, 88, Scientific journal
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  • Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells, T Konishi; H Satsu; Y Hatsugai; K Aizawa; T Inakuma; S Nagata; S Sakuda; H Nagasawa; M Shimizu, Oct. 2004, BRITISH JOURNAL OF PHARMACOLOGY, 143, 3, 379, 387, Scientific journal
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  • Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter, H Satsu; M Manabe; M Shimizu, Jul. 2004, FEBS LETTERS, 569, 1-3, 123, 128, Scientific journal
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  • Effects of tributyltin on barrier functions in human intestinal Caco-2 cells, M Tsukazaki; H Satsu; A Mori; Y Sugita-Konishi; M Shimizu, Mar. 2004, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 315, 4, 991, 997, Scientific journal
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  • Regulation of the human taurine transporter by TNF-alpha and an anti-inflammatory function of taurine in human intestinal Caco-2 cells., Mochizuki; T.; Satsu; H.; Nakano; T.; Shimizu; M., 2004, Biofactors, 21, 1-4, 137, 139, International conference proceedings
  • Regulation of interleukin-8 secretion in human intestinal epithelial Caco-2 cells by alpha-humulene, H Satsu; T Matsuda; T Toshimitsu; A Mori; T Mae; M Tsukagawa; M Kitahara; M Shimizu, 2004, BIOFACTORS, 21, 1-4, 137, 139, Scientific journal
  • Physiological significance of the taurine transporter and taurine biosynthetic enzymes in 3T3-L1 adipocytes, M Takasaki; H Satsu; M Shimizu, 2004, BIOFACTORS, 21, 1-4, 419, 421, Scientific journal
  • Development of the method for evaluating protective effect of food factors on THP-1-induced damage to human intestinal Caco-2 monolayers, F Watanabe; H Satsu; T Mochizuki; T Nakano; M Shiniizu, 2004, BIOFACTORS, 21, 1-4, 145, 147, Scientific journal
  • Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells, DO Son; H Satsu; Y Kiso; M Shimizu, 2004, BIOFACTORS, 21, 1-4, 395, 398, Scientific journal
  • Assessment system for dioxin absorption in the small intestine and prevention of its absorption by food factors, Y Natsume; H Satsu; K Kitamura; N Okamoto; M Shimizu, 2004, BIOFACTORS, 21, 1-4, 375, 377, Scientific journal
  • A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: Monoglyceride as an active compound, T Konishi; H Satsu; Y Hatsugai; K Aizawa; T Inakuma; S Nagata; S Sakuda; H Nagasawa; M Shimizu, 2004, BIOFACTORS, 22, 1-4, 71, 74, Scientific journal
  • Functional characterization and regulation of the taurine transporter and cysteine dioxygenase in human hepatoblastoma HepG2 cells, H Satsu; E Terasawa; Y Hosokawa; M Shimizu, Oct. 2003, BIOCHEMICAL JOURNAL, 375, 2, 441, 447, Scientific journal
  • Expression profiling of translation-associated genes in sporulating Bacillus subtilis and consequence of sporulation by gene inactivation, Y Ohashi; T Inaoka; K Kasai; Y Ito; S Okamoto; H Satsu; Y Tozawa; F Kawamura; K Ochi, Oct. 2003, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67, 10, 2245, 2253, Scientific journal
  • The effect of neuronal PC12 cells on the functional properties of intestinal epithelial Caco-2 cells., Satsu; H.; Yokoyama; T.; Ogawa; N.; Fujiwara-Hatano; Y.; Shimizu; M., 2003, Biosci. Biotech. Biochem., 67, 6, 1312, 1318, Scientific journal
  • Regulation of intestinal taurine transporter by cytokines., Shimizu; M.; Mochizuki; T.; Satsu; H., 2003, Adv. Exp. Med. Biol., 526, 213, 217, International conference proceedings
  • New model for studying the migration of immune cells into intestinal epithelial cell monolayers, A Mori; H Satsu; M Shimizu, 2003, CYTOTECHNOLOGY, 43, 1-3, 57, 64, Scientific journal
  • Evaluation of intestinal dioxin permeability by using human intestinal Caco-2 cell monolayers., Natsume; Y.; Satsu; H.; Hatsugai; Y.; Watanabe; H.; Sato; R.; Ashida; H.; Tukey; R.H.; Shimizu; M., 2003, Food Sci. Technol. Res., 9, 4, 364, 366, Scientific journal
  • Characterization of the human intestinal calcium transporter, CaT1, stably expressed in CHO cells, Y Takano; R Sato; H Satsu; M Shimizu, 2003, CYTOTECHNOLOGY, 43, 1-3, 113, 120, Scientific journal
  • Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells, T Mochizuki; H Satsu; M Shimizu, Apr. 2002, FEBS LETTERS, 517, 1-3, 92, 96, Scientific journal
  • Effect of dietary sulfur amino acids on the taurine content of rat tissues, H Satsu; Y Kobayashi; T Yokoyama; E Terasawa; M Shimizu, 2002, AMINO ACIDS, 23, 4, 447, 452, Scientific journal
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  • The changes in the neuronal PC12 and the intestinal epithelial Caco-2 cells during the coculture. The functional analysis using an in vitro coculture system, H Satsu; T Yokoyama; N Ogawa; Y Fujiwara-Hatano; M Shimizu, Jan. 2001, CYTOTECHNOLOGY, 35, 1, 73, 79, Scientific journal
  • Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism, Y Kobayashi; M Suzuki; H Satsu; S Arai; Y Hara; K Suzuki; Y Miyamoto; M Shimizu, Nov. 2000, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 48, 11, 5618, 5623, Scientific journal
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  • Identification of a taurine transport inhibitory substance in sesame seeds, K Ishizuka; A Kanayama; H Satsu; Y Miyamoto; K Furihata; M Shimizu, Jun. 2000, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 64, 6, 1166, 1172, Scientific journal
  • Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of Caco-2 cells, N Ogawa; H Satsu; H Watanabe; M Fukaya; Y Tsukamoto; Y Miyamoto; M Shimizu, Mar. 2000, JOURNAL OF NUTRITION, 130, 3, 507, 513, Scientific journal
  • Regulation of intestinal glucose transport by tea catechins, M Shimizu; Y Kobayashi; M Suzuki; H Satsu; Y Miyamoto, 2000, BIOFACTORS, 13, 1-4, 61, 65, Scientific journal
  • Physiological significance of taurine and the taurine transporter in intestinal epithelial cells, M Shimizu; H Satsu, 2000, AMINO ACIDS, 19, 3-4, 605, 614, Scientific journal
  • Hypertonicity stimulates taurine uptake and transporter gene expression in Caco-2 cells, H Satsu; Y Miyamoto; M Shimizu, Jun. 1999, BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1419, 1, 89, 96, Scientific journal
  • Acetic acid suppresses the increase of glycosidase activity during culture of Caco-2 intestinal epithelial cells, N Ogawa; H Satsu; H Watanabe; M Fukaya; Y Tsukamoto; Y Miyamoto; M Shimizu, 1999, ANIMAL CELL TECHNOLOGY: CHALLENGES FOR THE 21ST CENTURY, 361, 365, International conference proceedings
  • System b(0,+)-mediated regulation of lysine transport in Caco-2 human intestinal cells, H Satsu; H Watanabe; S Arai; M Shimizu, 1998, AMINO ACIDS, 14, 4, 379, 384, Scientific journal
  • Characterization and regulation of taurine transport in Caco-2, human intestinal cells, H Satsu; H Watanabe; S Arai; M Shimizu, Jun. 1997, JOURNAL OF BIOCHEMISTRY, 121, 6, 1082, 1087, Scientific journal

Misc.

  • Sep. 2023, 9, 1, 35, 37, Introduction scientific journal
  • Jan. 2023, 6, 14, 25, 30, Introduction scientific journal
  • Sep. 2022, 8, 1, 11, 13, Introduction scientific journal
  • Mar. 2022, 25, Report research institution
  • Mar. 2022, 25, Report research institution
  • Sep. 2021, 7, 1, 14, 16, Introduction scientific journal
  • Jul. 2021, 59, 7, 317, 319, Introduction scientific journal
  • Regulation of CXCR4 expression by taurine in macrophage-like cells, Satsu; H.; Fukumura; M.; Watari; K., 2021, Adv. Exp. Med. Biol., Introduction scientific journal
  • Sep. 2020, 6, 62, 64, Introduction scientific journal
  • Mar. 2020, 23, Report research institution
  • Sep. 2019, 5, 1, 45, 46, Introduction scientific journal
  • Mar. 2019, 22, 49, 53, Report research institution
  • Mar. 2019, 22, 55, 60, Report research institution
  • Mar. 2019, Report research institution
  • Sep. 2017, 3, 1, 39, 41, Introduction scientific journal
  • Nov. 2016, 31, 12, 70, 74, Introduction scientific journal
  • Sep. 2015, 1, 39, 41, Introduction scientific journal
  • 腸管の機能とポリフェノール, 清水 誠; 戸塚 護; 薩 秀夫, Jul. 2015, 日本ポリフェノール学会雑誌, 4, 1, 30, 36
  • Interaction between intestinal epithelial transporter and functional food components, Satsu Hideo, Jun. 2015, Vitamins, 89, 5・6, 275, 279, Report scientific journal
    DOI
  • 2012, 29, 2, 38, 44, Introduction scientific journal
  • 2011, 64, 4, 207, 214, Introduction scientific journal
  • Dec. 2010, 13, 79, 84, Introduction scientific journal
  • 2010, 6, 2, 131, 138, Introduction scientific journal
  • 2010, 27, 7, 39, 46, Introduction scientific journal
  • 2009, 117, 124, Introduction scientific journal
  • 2009, 29, 4, 16, 26, Introduction scientific journal
  • Dietary taurine attenuates dextran sulfate sodium (DSS)-induced experimental colitis in mice., Shimizu; M.; Zhao; Z.; Ishimoto; Y.; Satsu; H., 2009, Adv. Exp. Med. Biol., 643, 265, 271, Introduction international proceedings
    DOI
  • 2007, 10, 124, 127, Introduction scientific journal
  • 2007, 45, 4, 273, 281, Introduction scientific journal
  • 2006, 175, 175, 49, 53, Introduction scientific journal
  • 2005, 173, 22, 27, Introduction scientific journal
  • 2005, 18, 31, 40
  • 2004, 78, 11, 555, 563, Introduction scientific journal
  • 2003, 169, 44, 49, Introduction scientific journal
  • Characteristics of lysophosphatidylcholine in its inhibition of taurine uptake by human intestinal Caco-2 cells, K Ishizuka; Y Miyamoto; H Satsu; R Sato; M Shimizu, Apr. 2002, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66, 4, 730, 736, Introduction international proceedings
  • 2002, 163, 1, 4, Introduction scientific journal
  • 2002, 165, 26, 30, Introduction scientific journal
  • 2002, 51, 3, 169, 172, Introduction scientific journal
  • 2002, 51, 2, 89, 91, Introduction scientific journal
  • 2002, 100, 2, 155, 160, Introduction scientific journal
  • 2001, 75, 9, 976, 979, Introduction scientific journal
  • 2001, 161, 8, 14, Introduction scientific journal
  • 1999, 154, 49, 54, Introduction scientific journal
  • 1997, 55, 225, 229, Introduction scientific journal
  • 1997, 149, 17, 21, Introduction scientific journal

Books and Other publications

  • The physiological functions of taurine, Contributor, Satsu; H., Springer, 2023, Scholarly book
  • Regulation of CXCR4 expression by taurine in macrophage-like cells, Contributor, Satsu; H.; Fukumura; M.; Watari; K., Springer, 2022, 41-49, Scholarly book
  • Contributor, Sep. 2018, 239-250, Scholarly book
  • Contributor, Apr. 2018, 3-12, Scholarly book
  • Joint editor, May 2017, Scholarly book
  • Contributor, May 2017, Scholarly book
  • Contributor, 2017, 76-78, Scholarly book
  • Contributor, 2017, 85-87, Scholarly book
  • Contributor, 2017, 79-84, Scholarly book
  • Contributor, May 2015, 144-160, Scholarly book
  • Contributor, May 2014, 220-228, Scholarly book
  • Contributor, 2013, 146-147, Scholarly book
  • Joint editor, May 2011, Scholarly book
  • Contributor, May 2011, 247-264, Scholarly book
  • Contributor, 2011, 161-170, Scholarly book
  • Contributor, 2010, 145-151, Scholarly book
  • Contributor, 2008, 215-225, Scholarly book
  • Contributor, 2005, 225-236, Scholarly book
  • Contributor, 2005, 35-40, 49-54, 96-101, Scholarly book
  • The physiological functions of taurine., Contributor, Satsu, H, Kadowaki, M. and Furuya, S. eds., Scholarly book

Presentations

  • 16 Mar. 2025, 15 Mar. 2025, 16 Mar. 2025, Japanese
  • 15 Mar. 2025, 15 Mar. 2025, 16 Mar. 2025, Japanese
  • 03 Dec. 2024, 02 Dec. 2024, 03 Dec. 2024, Japanese
  • 02 Dec. 2024, 02 Dec. 2024, 03 Dec. 2024, Japanese
  • 02 Dec. 2024, 02 Dec. 2024, 03 Dec. 2024, Japanese
  • Jul. 2024, 23 Jul. 2024, 24 Jul. 2024, Japanese
  • May 2024, 24 May 2024, 26 May 2024, Japanese
  • May 2024, 24 May 2024, 26 May 2024, Japanese
  • May 2024, 24 May 2024, 26 May 2024, Japanese
  • Mar. 2024, 24 Mar. 2024, 27 Mar. 2024, Japanese
  • Mar. 2024, 24 Mar. 2024, 27 Mar. 2024, Japanese
  • Mar. 2024, 24 Mar. 2024, 27 Mar. 2024, Japanese
  • 30 Nov. 2023, 28 Nov. 2023, 01 Dec. 2023, Japanese, International conference
  • 30 Nov. 2023, 28 Nov. 2023, 01 Dec. 2023, Japanese, International conference
  • 18 Nov. 2023, 18 Nov. 2023, 19 Nov. 2023, Japanese
  • 18 Nov. 2023, 18 Nov. 2023, 19 Nov. 2023, Japanese
  • Nov. 2023, 14 Nov. 2023, 15 Nov. 2023, Japanese
  • Nov. 2023, 14 Nov. 2023, 15 Nov. 2023, Japanese
  • 27 May 2023, 27 May 2023, 27 May 2023, Japanese
  • 14 May 2023, 12 May 2023, 14 May 2023, Japanese
  • 14 May 2023, 12 May 2023, 14 May 2023, Japanese
  • 13 May 2023, 12 May 2023, 14 May 2023, Japanese
  • Mar. 2023, 14 Mar. 2023, 17 Mar. 2023, Japanese
  • Mar. 2023, 14 Mar. 2023, 17 Mar. 2023, Japanese
  • Mar. 2023, 14 Mar. 2023, 17 Mar. 2023, Japanese
  • 07 Mar. 2023, 06 Mar. 2023, 07 Mar. 2023, Japanese
  • Regulation of gene expression and cell function by taurine, Hideo Satsu, 22th IUNS-ICN, Dec. 2022, English, International conference
  • 08 Nov. 2022, 08 Nov. 2022, 09 Nov. 2022, Japanese
  • 08 Nov. 2022, 08 Nov. 2022, 09 Nov. 2022, Japanese
  • Jun. 2022, 10 Jun. 2022, 12 Jun. 2022, Japanese
  • Jun. 2022, 10 Jun. 2022, 12 Jun. 2022, Japanese
  • Jun. 2022, 10 Jun. 2022, 12 Jun. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • Mar. 2022, 15 Mar. 2022, 18 Mar. 2022, Japanese
  • 21 Nov. 2021, 20 Nov. 2021, 21 Nov. 2021, Japanese
  • 20 Nov. 2021, 20 Nov. 2021, 21 Nov. 2021, Japanese
  • 16 Nov. 2021, 16 Nov. 2021, 17 Nov. 2021, Japanese
  • 16 Nov. 2021, 16 Nov. 2021, 17 Nov. 2021, Japanese
  • 16 Nov. 2021, 16 Nov. 2021, 17 Nov. 2021, Japanese
  • 16 Nov. 2021, 16 Nov. 2021, 17 Nov. 2021, Japanese
  • 29 Oct. 2021, Japanese
  • 29 Oct. 2021, Japanese
  • Jul. 2021, Japanese
  • Jan. 2016, Japanese

Awards

  • Dec. 2024, Japan society
  • Dec. 2024, Japan society
  • Nov. 2023, Japan society
  • May 2023, Japan society
  • Nov. 2022, Japan society
  • International Meeting of JAACT2020 Best Poster Presentation Award, Tsukiho Hiura;Masahiko Suzuki;Kana Umetani;Mizuki Honda;Yuji Tsujikawa;Iwao Sakane;Hideo Satsu, Japanese Association for Animal Cell Technology (JAACT), Nov. 2020, International society
  • Nov. 2020, Japan society
  • Nov. 2020, Japan society
  • Jul. 2019, Japan society
  • Mar. 2019, Japan society
  • International Meeting of JAACT2018 Best Poster Presentation Award, Mizuki Honda,Mio Aida,Asuka Kamei,Hideo Satsu, Japanese Association for Animal Cell Technology (JAACT), Nov. 2018, International society
  • Feb. 2017, Japan society
  • Jul. 2012, Publisher
  • Mar. 2012, Japan society
  • Nov. 2011, International society
  • Oct. 2011, Japan society
  • May 2010, Japan society
  • Jun. 2008, Japan society

Research Projects

  • Apr. 2024, Coinvestigator, Others
  • Studies searching for urate-lowering food components using pharmacokinetic model of urate in the whole body, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), The University of Tokyo, Apr. 2020, Mar. 2024, Coinvestigator, Others, 20H00568, kaken
    対象リソースIRI
  • Search and analysis of food substances which could activate NK cells via IL-12, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Maebashi Institute of Technology, Apr. 2020, Mar. 2023, Principal investigator, Others, 20K05893, kaken
    対象リソースIRI
  • Development of assay system to search for food substances which prevent non-alcoholic fatty liver disease considering intestinal absorption, SATSU Hideo, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Maebashi Institute of Technology, Apr. 2017, Mar. 2020, Principal investigator, This study aimed to develop in vitro assessment system to search for food components which could prevent non-alcoholic fatty liver disease (NAFLD) after intestinal absorption and also analyze the identified functional food components. Human hepatic HepG2 cells were cultured with the medium containing fatty acid Mix (palmitic acid and oleic acid) and fructose, respectively. Consequently, incubation of HepG2 cells with fatty acid Mix or fructose resulted in the formation of intracellular lipid droplets and also accumulation of intracellular triglyceride. Next we examined the effect of several kinds of herbal extracts from Myanmar on fatty acid Mix-induced lipid droplets. We found that two kinds of Myanmar-derived herbal extracts significantly suppressed the formation of intracellular lipid droplets by fatty acid Mix., Others, 17K07796, kaken
    対象リソースIRI
  • Studies searching for functional food components to control novel SUA regulators, TAKADA Tappei, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), The University of Tokyo, Apr. 2016, Mar. 2020, Coinvestigator, By in vitro and in vivo experiments and clinical analyses, we revealed that 1) OAT10/SLC22A13 mediates physiological transport of urate and its dysfunctional missense variant (R377C) decreases gout risk and serum uric acid levels, 2) ABCG2 is a physiological exporter of uremic toxin indoxyl sulfate and a crucial factor influencing CKD progression, 3) some of antihyperuricemic drugs such as febuxostat are strong ABCG2 inhibitors, and osthol isolated from Cnidium monnieri fruit and flavonoids in Citrus fruits have potential to inhibit URAT1-mediated transport of urate., Others, 16H01808, kaken
    対象リソースIRI
  • Nov. 2014, Mar. 2019, Coinvestigator, Competitive research funding
  • Food functional study on the regulation of glucose reabsorption transporter SGLT2 in the kidney, SATSU HIDEO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Maebashi Institute of Technology, Apr. 2015, Mar. 2017, Principal investigator, We focused on sodium-dependent glucose transporter 2(SGLT2) that is responsible for glucose reabsorption in the kidney, a new drug target of diabetes, and tried to search for food factors which inhibit SGLT2 activity. We constructed a stable cell line expressing human SGLT2 and developed assay system to assess SGLT2 activity. By using this system, we performed screening of food substances which inhibit SGLT2 activity. As a result, we found that catechin gallate which is one of catechins in tea, and nobiletin which is mainly contained in citrus fruits inhibited SGLT2 activity. These flavonoids may be useful to prevent diabetes., Others, 15K14737, kaken
    対象リソースIRI
  • Regulation of intestinal epithelial glucose transporter by food factors to prevent or improve metabolic syndrome, SATSU HIDEO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Apr. 2012, Mar. 2015, Principal investigator, We analyzed the food substances that inhibit intestinal monosaccharide absorption to prevent the diseases caused by excessive carbohydrates. We searched for phytochemicals that inhibit glucose transporter SGLT1, responsible for glucose absorption, and also GLUT5, responsible for fructose absorption. We found that tangeretin contained in citrus fruits and epicatechin gallate contained in green tea inhibited SGLT1 and GLUT5 activity. Oral glucose tolerance test using mice showed that tangeretin significantly suppressed the increase in mouse blood glucose level., Others, 24580176, kaken
    対象リソースIRI

■Information on Social Contribution Activities

Social Activities

  • 21 Nov. 2024, 21 Nov. 2024
  • Nov. 2024, Nov. 2024
  • May 2024, May 2024
  • Sep. 2020, Sep. 2020
  • Jun. 2019, Jun. 2019
  • Jun. 2019, Jun. 2019
  • Apr. 2019, Apr. 2019
  • Dec. 2017, Dec. 2017
  • Mar. 2016, Mar. 2016
  • Nov. 2015, Nov. 2015
  • Jun. 2014, Jun. 2014