Researcher Profile and Settings

Researcher

• Name

  SADAKATA Tetsushi

Profile and Settings

• Name

  Tetsushi, Sadakata

• Profile

  CAPS proteins are known to associate with secretory vesicles and regulate their secretion. I have shown that CAPS2 is involved in the secretion of BDNF (brain-derived neurotrophic factor), which is important for the formation of neural networks (Sadakata et al., J. Neurosci., 2004; J. Comp. Neurol., 2007; Shinoda, Sadakata et al. Proc. Natl. Acad. Sci. USA., 2011).
  Expression analysis of human CAPS2 revealed that abnormal splicing occurs in some autistic patients (Sadakata et al., J. Clin. Invest., 2007). It was suggested that BDNF secretion is abnormal in brains expressing autistic-type CAPS2 protein, resulting in abnormal neural network formation (Sadakata et al., J. Clin. Invest., 2007; J. Neurosci., 2007). To prove this hypothesis, I generated genetically engineered mice that express only the autistic CAPS2 protein. These mice exhibited various autism-like traits, including abnormal social behavior (Sadakata et al., Proc. Natl. Acad. Sci. USA., 2012). Analysis of CAPS2 heterozygous mice revealed that a decrease in CAPS2 protein also causes autism (Sadakata et al., FEBS Lett., 2013).
  The CAPS2 protein was also found to bind to class II ARF proteins, indicating that CAPS and class II ARF proteins are involved in the formation of secretory vesicles in the Golgi apparatus (Sadakata et al; FEBS J., 2012; J. Neurosci., 2013; Neurosci. lett., 2017). We have also shown that Class II ARF proteins transport specific Na+ channels to neuroaxonal origins and are involved in essential tremor (Hosoi et al., J. Neurosci., 2019).

  
  I am currently studying other effects of microglia on brain development.

Other names

• T.Sadakata

Alternate Names

• Tetsushi Sadakata
• T Sadakata

Website

• URI

  https://researchmap.jp/sadakata

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University Graduate School of Medicine, Education and Research Support Center, Associate Professor

Education

• Apr. 1994, Mar. 1998, Tohoku University, Biological Institute, Faculty of Science, Undergraduate Student
• Apr. 1998, Mar. 2000, Osaka University, Graduate School of Medicine, Master's Student
• Apr. 2000, Mar. 2004, The University of Tokyo, Division of Neuroscience, Graduate School of Medicine, PhD Student

Degree

• Ph.D., Mar. 2004

Association Memberships

• The Japan Neuroscience Society
• Society for Neuroscience
• The Japanese Society for Neurochemistry
• The Japanese Biochemical Society

Research Experience

• Apr. 2001, Mar. 2004, RIKEN, Junior Research Associate
• Apr. 2004, Mar. 2007, Brain Science Institute, RIKEN, Laboratory for Molecular Neurogenesis, Staff Scientist
• Apr. 2007, Mar. 2010, Brain Science Institute, RIKEN, Laboratory for Molecular Neurogenesis, Special Postdoctoral Researcher
• Apr. 2010, Feb. 2011, Brain Science Institute, RIKEN, Laboratory for Molecular Neurogenesis, Staff Scientist
• Mar. 2011, Mar. 2015, Gunma University, Advanced Scientific Research Leaders Development Unit, Assistant Professor
• Apr. 2015, Mar. 2018, Gunma University, Advanced Scientific Research Leaders Development Unit, Lecturer
• Apr. 2018, Nov. 2018, Gunma University Graduate School of Medicine, Education and Research Support Center, Lecturer
• Dec. 2018, 9999, Gunma University Graduate School of Medicine, Education and Research Support Center, Associate Professor

Research Activities

Research Areas

• Life sciences, Pharmacology
• Life sciences, Neuroscience - general
• Life sciences, Laboratory animal science

Research Interests

• trafficking
• neuron
• autism
• microglia

Published Papers

• Critical factors for flow cytometry analysis of the brain., Mizuki Sadakata, Ayumu Konno, Akinori Takase, Tetsuhiro Kasamatsu, Takatoshi Iijima, Hirokazu Hirai, Tetsushi Sadakata., 2025, FEBS Journal, Scientific journal

  DOI
• CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning., Chiaki Ishii; Natsumi Shibano; Mio Yamazaki; Tomoki Arima; Yuna Kato; Yuki Ishii; Yo Shinoda; Yugo Fukazawa; Tetsushi Sadakata; Yoshitake Sano; Teiichi Furuichi, 2021, SCIENTIFIC REPORTS, 11, 1, Scientific journal

  DOI
• CAPS2 deficiency impairs the release of the social peptide, oxytocin, as well as oxytocin-associated social behavior., Shuhei Fujima; Ryosuke Yamaga; Haruka Minami; Shota Mizuno; Yo Shinoda; Tetsushi Sadakata; Manabu Abe; Kenji Sakimura; Yoshitake Sano; Teiichi Furuichi, 2021, JOURNAL OF NEUROSCIENCE, 41, 20, 4524, 4535, Scientific journal

  DOI
• The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice., Hisako Sugimoto; Takuro Horii; Jun-Na Hirota; Yoshitake Sano; Yo Shinoda; Ayumu Konno; Hirokazu Hirai; Yasuki Ishizaki; Hajime Hirase; Izuho Hatada; Teiichi Furuichi; Tetsushi Sadakata, 2021, MOLECULAR BRAIN, 14, 1, 1, 9, Scientific journal

  DOI
• Absence of thyroid hormone induced delayed dendritic arborization in mouse primary hippocampal neurons through insufficient expression of brain-derived neurotrophic factor., Hiroyuki Yajima; Izuki Amano; Sumiyasu Ishii; Tetsushi Sadakata; Wataru Miyazaki; Yusuke Takatsuru; Noriyuki Koibuchi, 2021, FRONTIERS IN ENDOCRINOLOGY, 12, 1, 13, Scientific journal

  DOI
• Deletion of Class II ADP-Ribosylation Factors in Mice Causes Tremor by the Nav1.6 Loss in Cerebellar Purkinje Cell Axon Initial Segments., Nobutake Hosoi; Koji Shibasaki; Mayu Hosono; Ayumu Konno; Yo Shinoda; Hiroshi Kiyonari; Kenichi Inoue; Shin-Ichi Muramatsu; Yasuki Ishizaki; Hirokazu Hirai; Teiichi Furuichi; Tetsushi Sadakata, 07 Aug. 2019, JOURNAL OF NEUROSCIENCE, 39, 32, 6339, 6353, Scientific journal

  DOI
• Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3., Yo Shinoda; Tetsushi Sadakata; Kaori Yagishita; Emi Kinameri; Ritsuko Katoh-Semba; Yoshitake Sano; Teiichi Furuichi, 2019, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 509, 2, 429, 434, Scientific journal

  DOI
• Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals, Yo Shinoda; Tetsushi Sadakata; Takumi Akagi; Yuriko Sakamaki; Tsutomu Hashikawa; Yoshitake Sano; Teiichi Furuichi, 11 Jun. 2018, NEUROSCIENCE LETTERS, 677, 65, 71, Scientific journal

  DOI
• CAPS2 deficiency affects environmental enrichment-induced adult neurogenesis and differentiation/survival of newborn neurons in the hippocampal dentate gyrus, Kaori Yagishita; Ritsuko Suzuki; Shota Mizuno; Ritsuko Katoh-Semba; Tetsushi Sadakata; Yoshitake Sano; Teiichi Furuichi; Yo Shinoda, Nov. 2017, NEUROSCIENCE LETTERS, 661, 121, 125, Scientific journal

  DOI
• The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination, Kanehiro Hayashi; Asako Furuya; Yuriko Sakamaki; Takumi Akagi; Yo Shinoda; Tetsushi Sadakata; Tsutomu Hashikawa; Kazuki Shimizu; Haruka Minami; Yoshitake Sano; Manabu Nakayama; Teiichi Furuichi, Mar. 2017, PLOS ONE, 12, 3, 1, 15, Scientific journal

  DOI
• Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways, Tetsushi Sadakata; Yo Shinoda; Yasuki Ishizaki; Teiichi Furuichi, Feb. 2017, NEUROSCIENCE LETTERS, 639, 88, 93, Scientific journal

  DOI
• Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments, Fumio Yoshikawa; Yumi Sato; Koujiro Tohyama; Takumi Akagi; Tamio Furuse; Tetsushi Sadakata; Mika Tanaka; Yo Shinoda; Tsutomu Hashikawa; Shigeyoshi Itohara; Yoshitake Sano; M. Said Ghandour; Shigeharu Wakana; Teiichi Furuichi, Nov. 2016, PLOS ONE, 11, 11, 1, 18, Scientific journal

  DOI
• CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus, Yo Shinoda; Chiaki Ishii; Yugo Fukazawa; Tetsushi Sadakata; Yuki Ishii; Yoshitake Sano; Takuji Iwasato; Shigeyoshi Itohara; Teiichi Furuichi, Aug. 2016, SCIENTIFIC REPORTS, 6, 1, 8, Scientific journal

  DOI
• Interaction of Ca2+-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain, Mayu Hosono; Yo Shinoda; Touko Hirano; Yasuki Ishizaki; Teiichi Furuichi; Tetsushi Sadakata, Mar. 2016, NEUROSCIENCE LETTERS, 617, 232, 235, Scientific journal

  DOI
• Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice, Yuriko Mishima; Yo Shinoda; Tetsushi Sadakata; Masami Kojima; Shigeharu Wakana; Teiichi Furuichi, Mar. 2015, SCIENTIFIC REPORTS, 5, 1, 6, Scientific journal

  DOI
• Age-dependent redistribution and hypersialylation of the central myelin paranodal loop membrane protein Opalin in the mouse brain, Yumi Sato; Fumio Yoshikawa; Tetsushi Sadakata; Yo Shinoda; Michinori Koebis; Teiichi Furuichi, Oct. 2014, NEUROSCIENCE LETTERS, 581, 14, 19, Scientific journal

  DOI
• Axonal Localization of Ca2+- Dependent Activator Protein for Secretion 2 Is Critical for Subcellular Locality of Brain-Derived Neurotrophic Factor and Neurotrophin-3 Release Affecting Proper Development of Postnatal Mouse Cerebellum, Tetsushi Sadakata; Wataru Kakegawa; Yo Shinoda; Mayu Hosono; Ritsuko Katoh-Semba; Yukiko Sekine; Yumi Sato; Chihiro Saruta; Yasuki Ishizaki; Michisuke Yuzaki; Masami Kojima; Teiichi Furuichi, Jun. 2014, PLOS ONE, 9, 6, 1, 10, Scientific journal

  DOI
• Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants, Tetsushi Sadakata; Yo Shinoda; Akira Sato; Hirotoshi Iguchi; Chiaki Ishii; Makoto Matsuo; Ryosuke Yamaga; Teiichi Furuichi, Dec. 2013, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 10, 12, 6335, 6353, Scientific journal

  DOI
• CAPS1 Deficiency Perturbs Dense-Core Vesicle Trafficking and Golgi Structure and Reduces Presynaptic Release Probability in the Mouse Brain, Tetsushi Sadakata; Wataru Kakegawa; Yo Shinoda; Mayu Hosono; Ritsuko Katoh-Semba; Yukiko Sekine; Yumi Sato; Mika Tanaka; Takuji Iwasato; Shigeyoshi Itohara; Kenichiro Furuyama; Yoshiya Kawaguchi; Yasuki Ishizaki; Michisuke Yuzaki; Teiichi Furuichi, Oct. 2013, JOURNAL OF NEUROSCIENCE, 33, 44, 17326, 17334, Scientific journal

  DOI
• Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice, Yo Shinoda; Tetsushi Sadakata; Teiichi Furuichi, Apr. 2013, EXPERIMENTAL ANIMALS, 62, 2, 71, 78, Scientific journal

  DOI
• Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene, Tetsushi Sadakata; Yo Shinoda; Megumi Oka; Yukiko Sekine; Teiichi Furuichi, Jan. 2013, FEBS LETTERS, 587, 1, 54, 59, Scientific journal

  DOI
• Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice, Tetsushi Sadakata; Yo Shinoda; Megumi Oka; Yukiko Sekine; Yumi Sato; Chihiro Saruta; Hideki Miwa; Mika Tanaka; Shigeyoshi Itohara; Teiichi Furuichi, Dec. 2012, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109, 51, 21104, 21109, Scientific journal

  DOI
• Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking, Tetsushi Sadakata; Yukiko Sekine; Megumi Oka; Makoto Itakura; Masami Takahashi; Teiichi Furuichi, Feb. 2012, FEBS JOURNAL, 279, 3, 384, 394, Scientific journal

  DOI
• Systematizing and Cloning of Genes Involved in the Cerebellar Cortex Circuit Development, Teiichi Furuichi; Yoko Shiraishi-Yamaguchi; Akira Sato; Tetsushi Sadakata; Jinhong Huang; Yo Shinoda; Kanehiro Hayashi; Yuriko Mishima; Mineko Tomomura; Hirozumi Nishibe; Fumio Yoshikawa, Jul. 2011, NEUROCHEMICAL RESEARCH, 36, 7, 1241, 1252, Scientific journal

  DOI
• Phase Advance of the Light-Dark Cycle Perturbs Diurnal Rhythms of Brain-derived Neurotrophic Factor and Neurotrophin-3 Protein Levels, Which Reduces Synaptophysin-positive Presynaptic Terminals in the Cortex of Juvenile Rats, Michiko Hamatake; Noriko Miyazaki; Kaori Sudo; Motoko Matsuda; Tetsushi Sadakata; Asako Furuya; Satoshi Ichisaka; Yoshio Hata; Chiaki Nakagawa; Koh-ichi Nagata; Teiichi Furuichi; Ritsuko Katoh-Semba, Jun. 2011, JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 24, 21478, 21487, Scientific journal

  DOI
• Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network, Yo Shinoda; Tetsushi Sadakata; Kazuhito Nakao; Ritsuko Katoh-Semba; Emi Kinameri; Asako Furuya; Yuchio Yanagawa; Hajime Hirase; Teiichi Furuichi, Jan. 2011, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 1, 373, 378, Scientific journal

  DOI
• Interaction of Calcium-dependent Activator Protein for Secretion 1 (CAPS1) with the Class II ADP-ribosylation Factor Small GTPases Is Required for Dense-core Vesicle Trafficking in the trans-Golgi Network, Tetsushi Sadakata; Yo Shinoda; Yukiko Sekine; Chihiro Saruta; Makoto Itakura; Masami Takahashi; Teiichi Furuichi, Dec. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 49, 38710, 38719, Scientific journal

  DOI
• Phospholipase D Family Member 4, a Transmembrane Glycoprotein with No Phospholipase D Activity, Expression in Spleen and Early Postnatal Microglia, Fumio Yoshikawa; Yoshiko Banno; Yoshinori Otani; Yoshihide Yamaguchi; Yuko Nagakura-Takagi; Noriyuki Morita; Yumi Sato; Chihiro Saruta; Hirozumi Nishibe; Tetsushi Sadakata; Yo Shinoda; Kanehiro Hayashi; Yuriko Mishima; Hiroko Baba; Teiichi Furuichi, Nov. 2010, PLOS ONE, 5, 11, 1, 13, Scientific journal

  DOI
• Expression of the IP(3)R1 Promoter-Driven nls-LacZ Transgene in Purkinje Cell Parasagittal Arrays of Developing Mouse Cerebellum, Daisuke Furutama; Noriyuki Morita; Riya Takano; Yukiko Sekine; Tetsushi Sadakata; Yo Shinoda; Kanehiro Hayashi; Yuriko Mishima; Katsuhiko Mikoshiba; Richard Hawkes; Teiichi Furuichi, Oct. 2010, JOURNAL OF NEUROSCIENCE RESEARCH, 88, 13, 2810, 2825, Scientific journal

  DOI
• Ca2+-dependent activator protein for secretion 2 and autistic-like phenotypes, Tetsushi Sadakata; Teiichi Furuichi, Jul. 2010, NEUROSCIENCE RESEARCH, 67, 3, 197, 202, Scientific journal

  DOI
• Developmentally Regulated Ca2+-Dependent Activator Protein for Secretion 2 (CAPS2) is Involved in BDNF Secretion and is Associated with Autism Susceptibility, Tetsushi Sadakata; Teiichi Furuichi, Sep. 2009, CEREBELLUM, 8, 3, 312, 322, Scientific journal

  DOI
• Response to the letter by Eran et al., Tetsushi Sadakata; Teiichi Furuichi, 2009, Journal of Clinical Investigation, 119, 4, 679, 680, Scientific journal

  DOI
• Cerebellar development transcriptome database (CDT-DB): Profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum, Akira Sato; Yukiko Sekine; Chihiro Saruta; Hirozumi Nishibe; Noriyuki Morita; Yumi Sato; Tetsushi Sadakata; Yo Shinoda; Toshio Kojima; Teiichi Furuichi, Oct. 2008, NEURAL NETWORKS, 21, 8, 1056, 1069, Scientific journal

  DOI
• Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients, Tetsushi Sadakata; Miwa Washida; Yoshimi Iwayama; Satoshi Shoji; Yumi Sato; Takeshi Ohkura; Ritsuko Katoh-Semba; Mizuho Nakajima; Yukiko Sekine; Mika Tanaka; Kazuhiko Nakamura; Yasuhide Iwata; Kenji J. Tsuchiya; Norio Mori; Sevilla D. Detera-Wadleigh; Hironobu Ichikawa; Shigeyoshi Itohara; Takeo Yoshikawa; Teiichi Furuichi, Apr. 2007, JOURNAL OF CLINICAL INVESTIGATION, 117, 4, 931, 943, Scientific journal

  DOI
• Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants, Tetsushi Sadakata; Miwa Washida; Teiichi Furuichi, Apr. 2007, BMC NEUROSCIENCE, 8, 25, 1, 11, Scientific journal

  DOI
• Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice, Tetsushi Sadakata; Miwa Washida; Noriyuki Morita; Teiichi Furuichi, Mar. 2007, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 55, 3, 301, 311, Scientific journal

  DOI
• Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release, Tetsushi Sadakata; Wataru Kakegawa; Akira Mizoguchi; Miwa Washida; Ritsuko Katoh-Semba; Fumihiro Shutoh; Takehito Okamoto; Hisako Nakashima; Kazushi Kimura; Mika Tanaka; Yukiko Sekine; Shigeyoshi Itohara; Michisuke Yuzaki; Soichi Nagao; Teiichi Furuichi, Mar. 2007, JOURNAL OF NEUROSCIENCE, 27, 10, 2472, 2482, Scientific journal

  DOI
• Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain, Tetsushi Sadakata; Teiichi Furuichi, Sep. 2006, NEUROSCIENCE LETTERS, 405, 3, 217, 222, Scientific journal

  DOI
• Differential distributions of the Ca2+-dependent activator protein for secretion family proteins (CAPS2 and CAPS1) in the mouse brain, Tetsushi Sadakata; Makoto Itakura; Shunji Kozaki; Yukiko Sekine; Masami Takahashi; Teiichi Furuichi, 10 Apr. 2006, Journal of Comparative Neurology, 495, 6, 735, 753, Scientific journal

  DOI
• The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival, T Sadakata; A Mizoguchi; Y Sato; R Katoh-Semba; M Fukuda; K Mikoshiba; T Furuichi, Jan. 2004, JOURNAL OF NEUROSCIENCE, 24, 1, 43, 52, Scientific journal

  DOI
• Deciphering the genetic blueprint of cerebellar development by the gene expression profiling informatics, A Sato; N Morita; T Sadakata; F Yoshikawa; Y Shiraishi-Yamaguchi; JH Huang; S Shoji; M Tomomura; Y Sato; E Suga; Y Sekine; A Kitamura; Y Shibata; T Furuichi, 2004, NEURAL INFORMATION PROCESSING, 3316, 880, 884, Scientific journal

  DOI
• The effects of amiloride on the labellar taste receptor cells of the fleshfly Boettcherisca peregrina, T Sadakata; H Hatano; T Koseki; M Koganezawa; Shimada, I, May 2002, JOURNAL OF INSECT PHYSIOLOGY, 48, 5, 565, 570, Scientific journal

  DOI
• Increase of calmodulin III gene expression by mu-opioid receptor stimulation in PC12 cells, SY Niu; CH Kuo; Y Gan; E Nishikawa; T Sadakata; H Ichikawa; N Miki, Dec. 2000, JAPANESE JOURNAL OF PHARMACOLOGY, 84, 4, 412, 417, Scientific journal

  DOI
• Pur alpha, a single-stranded DNA binding protein, suppresses the enhancer activity of cAMP response element (CRE), T Sadakata; CH Kuo; H Ichikawa; E Nishikawa; SY Niu; E Kumamaru; N Miki, Apr. 2000, MOLECULAR BRAIN RESEARCH, 77, 1, 47, 54, Scientific journal

  DOI
• Calmodulin functions as an activator of Pur alpha binding to single-stranded purine-rich DNA elements (PUR elements), CH Kuo; E Nishikawa; H Ichikawa; T Sadakata; SY Niu; N Miki, Feb. 1999, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 255, 2, 406, 411, Scientific journal

  DOI
• The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells., Teiichi Furuichi; Yuko Muto; Tetsushi Sadakata; Yumi Sato; Kanehiro Hayashi; Yoko Shiraishi-Yamaguchi; Yo Shinoda, 2021, MOLECULAR BRAIN, 14, 1, Scientific journal

  DOI
• Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain., Bin Xu; Hiroya Shimauchi-Ohtaki; Yuhei Yoshimoto; Tetsushi Sadakata; Yasuki Ishizaki, Jan. 2023, Journal of Neuroinflammation, 20, 1, Scientific journal

  DOI
• Loss of CAPS2/Cadps2 Leads to Exocrine Pancreatic Cell Injury and Intracellular Accumulation of Secretory Granules in Mice., Yotaroh Sato; Miho Tsuyusaki; Hiromi Takahashi-Iwanaga; Rena Fujisawa; Atsushi Masamune; Shin Hamada; Ryotaro Matsumoto; Yu Tanaka; Yoichi Kakuta; Yumi Yamaguchi-Kabata; Tamio Furuse; Shigeharu Wakana; Takuya Shimura; Rika Kobayashi; Yo Shinoda; Ryo Goitsuka; So Maezawa; Tetsushi Sadakata; Yoshitake Sano; Teiichi Furuichi, 2022, Frontiers in Molecular Biosciences, 9, 1040237, 1, 18, Scientific journal

  DOI
• クラスIIARFタンパク質は、小脳プルキンエ細胞の軸索起始部へのNav1.6チャネルの輸送に関与する, ;;;;;;, Sep. 2019, 92回, [1T14a
• 細胞のメカニズムと神経疾患　Nav1.6の軸索起始部への輸送異常と本態性振戦, 定方 哲史, Aug. 2021, 39, 8, 920
• Analysis of autism-related gene CAPS2, Sadakata Tetsushi, Aug. 2016, 88, 4, 501, 505

  DOI
• ヒトPHYHIPL遺伝子のSer19Stop SNPは小脳の機能に影響を与える, 定方 哲史, Nov. 2021, 94回, [P
• GABAB receptor activation induces phasic neurotransmitter release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles., Peter Koppensteiner; Pradeep Bhandari; Cihan Önal; Carolina Borges-Merjane; Elodie Le Monnier; Utsa Roy; Yukihiro Nakamura; Tetsushi Sadakata; Makoto Sanbo; Masumi Hirabayashi; JeongSeop Rhee; Nils Brose; Peter Jonas; Ryuichi Shigemoto, 2024, Proceedings of the National Academy of Sciences of the United States of America., Scientific journal
• ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development, Yoshinobu Hara; Takehiko Katsuyama; Masahiro Fukaya; Takeyuki Sugawara; Tomoko Shiroshima; Tetsushi Sadakata; Noriko Osumi; Hiroyuki Sakagami, 17 Oct. 2023, eNeuro, 10, 11, ENEURO.0125, 23.2023, Scientific journal

  DOI
• Calcium-dependent activator protein for secretion 2 is involved in dopamine release in mouse midbrain neurons, Hirotoshi Iguchi; Takumi Katsuzawa; Chihiro Saruta; Tetsushi Sadakata; Shota Kobayashi; Yumi Sato; Akira Sato; Yoshitake Sano; So Maezawa; Yo Shinoda; Teiichi Furuichi, 18 Jul. 2024, Frontiers in Molecular Neuroscience, 17, Scientific journal

  DOI
• Maternal Immunoglobulin G Affects Brain Development of Mouse Offspring., Mizuki Sadakata; Kazuki Fujii; Ryosuke Kaneko; Emi Hosoya; Hisako Sugimoto; Reika Kawabata-Iwakawa; Tetsuhiro Kasamatsu; Shoko Hongo; Yumie Koshidaka; Akinori Takase; Takatoshi Iijima; Keizo Takao; Tetsushi Sadakata, 2024, Journal of Neuroinflammation, 21, 114, 1, 20, Scientific journal

  DOI
• The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells., Furuichi Teiichi;Muto Yuko;Sadakata Tetsushi;Sato Yumi;Hayashi Kanehiro;Shiraishi-Yamaguchi Yoko;Shinoda Yo, Jun. 2021, Molecular brain, 14, 1

  DOI
• Synaptic transmission in hippocampus of CAPS1 conditional KO mice, Ishii, Chiaki;Shinoda, Yo;Sadakata, Tetsushi;Furuichi, Teiichi, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S184, S184
• Response to the letter by Eran et al., Tetsushi Sadakata; Teiichi Furuichi, 2009, Journal of Clinical Investigation, 119, 4, 679, 680, Scientific journal

  DOI

MISC

• 小脳形成の遺伝子システム, 古市貞一; 森田規之; 佐藤明; 定方哲史, 2003, 25, 11, 22, Introduction scientific journal
• 有芯小胞分泌関連タンパク質CAPS2研究の展開～自閉症との関連～, 定方哲史, 2007, 46, 4, 836, 843, Introduction scientific journal
• 自閉症に関連する遺伝子の研究, 定方哲史, 2007, 104, 8, 9
• 自閉症の遺伝要因とCAPS2遺伝子, 定方哲史; 篠田陽; 古市貞一, 2008, 26, 12, 209, 217, Introduction scientific journal
• CADPS2, 定方哲史; 古市貞一, 2008, 8, 2, 150, 151, Introduction scientific journal
• 発達障害の新たな遺伝子 CADPS2と自閉症感受性, 定方哲史; 古市貞一, 2009, 9, 3, 240, 246, Introduction scientific journal
• 有芯小胞の分泌制御因子CAPS2と自閉症感受性, 定方哲史; 篠田陽; 林周宏; 古市貞一, 2010, 28, 5, 63, 69, Introduction scientific journal
• 自閉症感受性候補遺伝子CAPS2/CADPS2における遺伝子多型とノックアウトマウスの行動障害, 定方哲史; 古市貞一, 2011, 239, 6, 701, 707, Introduction scientific journal
• ゴルジ体における有芯小胞の生合成とCAPSタンパク質の役割, 定方哲史; 篠田陽; 古市貞一, 2012, 63, 5, 414, 415, Introduction scientific journal

  DOI
• Analysis of autism-related gene CAPS2, Tetsushi Sadakata, 2016, Seikagaku, 88, 4, 501, 505, Book review

  DOI
• 高齢者の体が震える原因とは？ ～本態性振戦発症メカニズムの解明～, 定方哲史, 2019, 6/24, Introduction commerce magazine
• 自閉症の感受性候補遺伝子と動物モデル, 篠田陽; 定方哲史; 林周宏; 古市貞一, 2009, 20, 4, 303, 310, Introduction scientific journal

  DOI
• 自閉症の発症要因と動物モデル, 篠田陽; 定方哲史; 三島百合子; 古市貞一, 2012, 30, 2, 236, 241, Introduction scientific journal
• Nav1.6の軸索起始部への輸送異常と本態性振戦, 定方哲史, 2021, 39, 8
• モデルマウスを用いた本態性振戦発症機序の解明, 細井延武; 柴崎貢志; 今野歩; 村松慎一; 石崎泰樹; 平井宏和; 古市貞一; 定方哲史, Aug. 2018, 北関東医学会総会プログラム・抄録, 65th, 3, 31, 211
• BDNFの分泌と自閉症, 定方哲史; 篠田陽; 古市貞一, 2014
• CAPS2タンパク質による有芯小胞分泌経路の制御と発達障害の感受性, 古市貞一; 定方哲史; 篠田陽; 仙波りつ子, 2009
• 【神経回路の制御と脳機能発現のメカニズム 細胞移動・接着から記憶・学習・行動発現までの分子基盤解明と研究を躍進させる最新技術】神経回路の破綻による疾患 自閉症の遺伝要因とCAPS2遺伝子, 定方 哲史; 篠田 陽; 古市 貞一, Jul. 2008, 26, 12, 2015, 2023
• マウス小脳発達のトランスクリプトーム・データベース(Cerebellar development transcriptome database), 古市 貞一; 佐藤 明; 定方 哲史; 松木 亨; 吉川 文生; 森田 規之; 佐藤 友美; 白石 陽子[山口]; 菅 恵美子; 関根 友紀子; 北村 愛子; 柴田 泰行, Aug. 2004, 神経化学, 43, 2-3, 394, 394
• 神経栄養因子の分泌に関わる新規遺伝子CAPS2の解析(The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival), 定方 哲史; 溝口 明; 佐藤 友美; 仙波 りつ子; 福田 光則; 御子柴 克彦; 古市 貞一, Aug. 2004, 神経化学, 43, 2-3, 529, 529
• 生後発達期のマウス小脳における遺伝子発現の解析, 佐藤明; 中村浩; 白石陽子; 鏡良弘; 定方哲史; 古市貞一, 2000, 72, 8

Books etc

• 分子・細胞・シナプスからみる脳（シリーズ脳科学５）, Joint work, 2008
• 発達障害白書 2009年版, Joint work, 2009
• 自閉症支援のすべて, Joint work, 2011

Presentations

• Comprehensive quantitative analysis of the mouse brain using flow cytometry., Tetsushi Sadakata, Mizuki Sadakata, Ayumu Konno, Tetsuhiro Kasamatsu, NEURO2024（第47回日本神経科学大会　第67回日本神経化学会大会　第46回日本生物学的精神医学会年会）, 24 Jul. 2024, English
• Maternal Immunoglobulin G Affects Brain Development of Mouse Offspring., Mizuki Sadakata, Ryosuke Kaneko, Takatoshi Iijima, Keizo Takao, Tetsushi Sadakata, NEURO2024（第47回日本神経科学大会　第67回日本神経化学会大会　第46回日本生物学的精神医学会年会）, 24 Jul. 2024, English
• The Influence of Breast Milk on Brain Development via Microglia, Mizuki Sadakata, Keizo Takao, Ryosuke Kaneko, Takatoshi Iijima, Tetsushi Sadakata., 第46回日本神経科学大会, 03 Aug. 2023, English
• 母乳がミクログリアを介して脳の発達に与える影響について, 第5回グリアデコード領域会議, 08 Feb. 2023
• Maternal immunoglobulin G affects brain development of mouse offspring, 第13回国際放射線神経生物学会, 09 Mar. 2024
• 母乳がミクログリアを介して子の脳の発達に与える影響について, 定方哲史, 第5回 和光-精神神経懇話会, 10 Dec. 2022, Japanese, Japan, Domestic conference
• 子の脳の発達に影響を与える母乳の因子について, 定方哲史, 産学連携協定締結金融機関等意見交換会, 15 Nov. 2022, Japanese, Japan, Domestic conference
• 母乳がミクログリアを介して脳の発達に与える影響について, 定方瑞樹、高雄啓三、金子涼輔、飯島崇利、定方哲史, 第4回グリアデコード領域会議, 30 Sep. 2022, Japanese, Japan, Domestic conference
• 母乳がミクログリアを介して脳の発達に与える影響について, 定方哲史, 第3回グリアデコード領域会議, 17 Dec. 2021, Japanese, Japan, Domestic conference
• 母性因子がミクログリアを介して子の脳の発達に与える影響の解析, 定方瑞樹、高雄啓三、金子涼輔、飯島崇利、定方哲史, NEURO2022（第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会　合同大会）, 02 Jul. 2022, English, Japan, Domestic conference
• 母性因子がミクログリアを介して子の脳の発達に与える影響の解析, 定方哲史、高雄啓三、金子涼輔、飯島崇利, NEURO2022（第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会　合同大会）, 02 Jul. 2022, English, Japan, Domestic conference
• 精神・神経疾患に関連する遺伝子, 定方哲史, 金沢医科大学　第16回 大学院医学研究セミナー, Oct. 2017, Japanese, Japan, Domestic conference
• 遺伝子と病気, 定方哲史, 公開講座・世界脳週間2019, Jun. 2019, Japanese, Japan, Domestic conference
• The therapeutic effect of transplanted human iPS-derived vascular endothelial cells on white matter ischemic damage, Bin Xu、定方哲史, 日本学術振興会サイエンス・ダイアログ, 22 Oct. 2021, English, Japan, Domestic conference
• 子の脳の発達に影響を与える母乳の因子について, 定方哲史, フードテックグランプリ2022, 15 Oct. 2022, 15 Oct. 2022, 15 Oct. 2022, Japanese, Japan, Domestic conference
• Axonal transport of Caps2 splice variant linked to BDNF coordination of brain circuit development and autism-related behavior in a mouse model., Tetsushi Sadakata and Teiichi Furuichi, 第59回北関東医学会総会, Sep. 2012
• CAPS2遺伝子異常による自閉症発症機序の解明, 定方哲史, 第85回日本生化学会大会, Dec. 2012
• CAPS2スプライシング異常による自閉症モデルマウスの解析, 定方哲史, Neuro2013（第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同大会）, Jun. 2013
• 自閉症モデルマウスを用いた発症メカニズムの解明, 定方哲史, 平成２５年度生理学研究所研究会, Jun. 2013
• 自閉症モデルマウスを用いた発症メカニズムの解明, 定方哲史, 包括的神経グリア研究会2013, Jan. 2013
• Reduced axonal localization of a Caps2 splice variant impairs polarization of BDNF release and causes autistic-like behavior in mice, Tetsushi Sadakata, The 11th Japanese Association of Scientists in Singapore (JASS), Nov. 2012, Singapore
• CAPS2のsplicing異常と自閉症, 定方哲史、古市貞一, 平成24年度日本生化学会関東支部例会, Jun. 2012
• 自閉症関連遺伝子CAPS2, 定方哲史, 第61回北関東医学会総会, Sep. 2014
• BDNFの分泌と自閉症, 定方哲史, 第36回日本生物学的精神医学会・第57回日本神経化学会大会合同年会, Sep. 2014
• Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice, Tetsushi Sadakata, 第5回国際放射線神経生物学会大会, Feb. 2015
• BDNFの局所性分泌に異常をきたす自閉症モデルマウスの解析, 定方哲史, 第38回日本神経科学大会, Jul. 2015
• Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice, Tetsushi Sadakata, 第58回日本神経化学会大会, Sep. 2015
• 本態性振戦の発症メカニズムの解明, 定方哲史, 第3回包括的神経グリア研究会, Jan. 2016
• 自閉症モデルマウスを用いた包括的解析, 定方哲史, 第２回生物学的自閉症研究会, Jul. 2015
• Autistic-like phenotypes in Cadps2/CAPS2 knockout mice and aberrant CADPS2 splicing in autistic patients, Tetsushi Sadakata, Teiichi Furuichi, BMB2007（第30回日本分子生物学会年会・第80回日本生化学会大会　合同大会）, Dec. 2007
• 自閉症の発症に関連する遺伝子CAPS2の解析, 定方哲史, Neuro2007（第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会 合同大会）, Sep. 2007
• 自閉症に関する遺伝子の研究, 定方哲史, 第6回日本自閉症スペクトラム学会, Aug. 2007
• Reduced axonal transport of a Cadps2 splice variant causes impaired BDNF-mediated brain circuit development and autism-related behavior in a mouse model, Tetsushi Sadakata, Yo Shinoda, Yukiko Sekine, Megumi Oka, Yumi Sato, Mika Tanaka, Shigeyoshi Itohara, Shigeharu Wakana, Teiichi Furuichi, 第2回国際放射線神経生物学会大会, Nov. 2011
• CAPS2 protein-mediated regulation of dense-core vesicle secretion pathway and susceptivility to developmental disorders, Tetsushi Sadakata, Yo Shinoda, Teiichi Furuichi, 第１回放射線神経生物学研究集会, Jan. 2011
• Interaction of CAPS1 with the class II ARF small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network, Tetsushi Sadakata, Yo Shinoda, Teiichi Furuichi, BMB2010（第33回日本分子生物学会年会・第83回日本生化学会大会合同大会）, Dec. 2010
• CAPS2 protein-mediated regulation of dense-core vesicle secretion pathway and susceptibility to developmental disorders, Tetsushi Sadakata, 第82回日本生化学会大会, Oct. 2009
• The functional analyses of CAPS family proteins, Tetsushi Sadakata, Yo Shinoda, Teiichi Furuichi, 第33回日本神経科学大会, Jul. 2008
• CADPS2/CAPS2遺伝子と自閉症との関連－ノックアウトマウスの解析と自閉症患者におけるスプライシング異常, 定方哲史、鷲田美和、岩山佳美、大倉勇史、仙波りつ子、田中三佳、森則夫、市川宏伸、糸原重美、吉川武男、古市貞一, 第50回日本神経化学会大会, Sep. 2007
• Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum, Tetsushi Sadakata, Wataru Kakegawa, Yo Shinoda, Mayu Hosono, Ritsuko Katoh-Semba, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Yasuki Ishizaki, Michisuke Yuzaki, Masami Kojima, Teiichi Furuichi, The 44th Annual Meeting of the Society for Neuroscience, Nov. 2014, Washington, DC
• Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice, Tetsushi Sadakata, Yo Shinoda, Megumi Oka, Yukiko Sekine, Yumi Sato, Chihiro Saruta, Hideki Miwa, Mika Tanaka, Shigeyoshi Itohara, Teiichi Furuichi, The 43rd Annual Meeting of the Society for Neuroscience, Nov. 2013, San Diego
• CAPS2 protein-mediated regulation of dense-core vesicle secretion pathway and susceptibility to developmental disorders, Tetsushi Sadakata, Yo Shinoda, Teiichi Furuichi, The 18th World Congress on Psychiatric Genetics, Oct. 2010, Athens, Greece
• Autistic-like phenotypes in CADPS2/CAPS2 knockout mice and aberrant CADPS2 splicing in autistic patients, Tetsushi Sadakata, Ritsuko Katoh-Semba, Mika Tanaka, Shigeyoshi Itohara, Takeo Yoshikawa, Teiichi Furuichi, The 37th Annual Meeting of Society for Neuroscience, Nov. 2007, San Diego, California, USA
• CAPS2のexon3スキップと自閉症, 定方哲史, BMB2015（第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会）, Dec. 2015
• ペプチドを含む有芯小胞はGolgi体よりいかにして生まれるか？, 定方哲史、篠田陽、古市貞一, 第36回日本神経内分泌学会, Sep. 2009
• CAPS familyタンパク質の有芯小胞トラフィッキングにおける役割, 定方哲史、古市貞一, 第32回日本神経科学大会, Sep. 2009
• 有芯小胞のトラフィッキングにおけるCAPSファミリータンパク質の働き, 定方哲史、古市貞一, BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）, Dec. 2008
• CAPS1とクラスII ARFはゴルジ体における有芯小胞の生成に関わる, 定方哲史、篠田陽、古市貞一, 第82回日本生化学会大会, Oct. 2009
• Analysis of autism-related gene CAPS2/CADPS2, Tetsushi Sadakata, The 8th Biennial Meeting of the Asia-Pacific Society for Neurochemistry (APSN), Jun. 2008, Shanghai, P.R. China
• 小胞の輸送・分泌に関与する遺伝子と疾患, 定方哲史, 第60回日本神経化学会大会, Sep. 2017

Works

• Jun. 2019

Industrial Property Rights

• Patent right, 特願2003-140684, 19 May 2003, 特開2004-337126(P2004-337126A)
• Patent right, 特願2004-271208, 17 Sep. 2004, 特開2006-81496(P2006-81496A)
• Patent right, 特願2006-184655, 04 Jul. 2006, 特開2008-11744(P2008-11744A)

Awards

• Excellent Presentation Award, Tetsushi Sadakata, KITAKANTO Medical Society, 2012
• The Award for Young Investigator, Tetsushi Sadakata, Japanese Society for Neurochemistry, 2007
• Young Investigator Award, Tetsushi Sadakata, Japan Neuroendocrine Society, 2009
• The Japan Neuroscience Society Young Investigator Award, 2009

Research Projects

• Apr. 2020, Mar. 2021, Principal investigator, Competitive research funding
• Apr. 2008, Mar. 2010, Principal investigator, Competitive research funding
• Apr. 2019, Mar. 2023, Principal investigator, Competitive research funding
• Apr. 2011, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2013, Mar. 2015, Principal investigator, Competitive research funding
• Apr. 2005, Mar. 2008, Principal investigator, Competitive research funding
• Apr. 2009, Mar. 2011, Principal investigator, Competitive research funding
• Dec. 2009, Sep. 2011, Principal investigator, Competitive research funding
• Apr. 2011, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2013, Mar. 2017, Principal investigator, Competitive research funding
• Apr. 2015, Mar. 2016, Principal investigator, Competitive research funding
• Apr. 2018, Mar. 2019, Principal investigator, Competitive research funding
• Apr. 2019, Mar. 2020, Principal investigator, Competitive research funding
• Principal investigator, Competitive research funding
• Apr. 2017, Mar. 2018, Principal investigator, Competitive research funding
• Apr. 2017, Mar. 2018, Principal investigator, Competitive research funding
• Apr. 2007, Mar. 2010, Principal investigator, Competitive research funding
• Oct. 2008, Mar. 2010, Principal investigator, Competitive research funding
• Dec. 2009, Oct. 2010, Principal investigator, Competitive research funding
• Apr. 2010, Mar. 2011, Principal investigator, Competitive research funding
• Apr. 2010, Mar. 2011, Principal investigator, Competitive research funding
• Apr. 2011, Mar. 2012, Principal investigator, Competitive research funding
• Feb. 2012, Jan. 2013, Principal investigator, Competitive research funding
• Apr. 2012, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2012, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2012, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2012, Mar. 2013, Principal investigator, Competitive research funding
• Apr. 2013, Mar. 2014, Principal investigator, Competitive research funding
• Apr. 2013, Mar. 2014, Principal investigator, Competitive research funding
• Apr. 2014, Mar. 2016, Principal investigator, Competitive research funding
• Apr. 2016, Mar. 2017, Principal investigator, Competitive research funding
• Apr. 2016, Mar. 2017, Principal investigator, Competitive research funding
• Dec. 2016, Dec. 2017, Principal investigator, Competitive research funding
• Dec. 2020, Nov. 2021, Principal investigator
• Apr. 2022, Mar. 2026, Principal investigator
• Dec. 2021, Sep. 2023, Principal investigator
• Apr. 2021, Mar. 2023, Principal investigator
• Apr. 2021, Mar. 2023, Principal investigator
• Dec. 2021, Nov. 2022, Principal investigator
• The role of CAPS in the activity-dependent dense-core vesicle exocytosis: function and impairment, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Tokyo University of Science, Apr. 2022, Mar. 2025, Coinvestigator, 22K06447

  対象リソースIRI
• Apr. 2023, Mar. 2024, Principal investigator
• Regulatory mechanism and cellular dynamics of exocytosis of BDNF-containing secretory vesicles by CAPS2, FURUICHI Tei-Ichi; SADAKATA Tetsushi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), The Institute of Physical and Chemical Research, 2008, 2010, We analyzed cellular function and biological significance of secretion-associated protein CAPS and reported the following findings. 1) CAPS2 promotes kinetics of activity-dependent secretion of brain-derived neuotrophic factor BDNF. CAPS2 KO mice have impairments in development and function of GABAergic inhibitory circuits and exhibit increased anxiety-like phenotype. 2) In addition to involvement in exocytosis of dense core vesicles, CAPS associates with small GTPase Arf4/5 and is associated with biogenesis and trafficking of dense-core vesicles in the trans-Golgi network., Competitive research funding, 20300134

  対象リソースIRI

Social Contribution

Social Contribution

• サイエンス・ダイアログ, Japan Society for the Promotion of Science, 22 Oct. 2021, Gunma Maebashi High School, Introduce high school students to cutting-edge science　(Target:　High school students)
• 公開シンポジウム 最新の医療 －画像・神経生理・神経心理・遺伝の立場からー, Aug. 2007
• 公開講座・世界脳週間2012, Apr. 2012
• 公開講座・世界脳週間2019, Jun. 2019
• 理化学研究所和光地区一般公開, 2002, 2009
• 「こころの発達」臨床教育センター 公開シンポジウム, Jan. 2008

Media Coverage

• 母乳の抗体が子の脳に作用, Other than myself, 02 May 2025, Paper
• モデルマウスによる糖尿病と鬱の関連性を示唆した論文(Sadakata et al., J. Neurosci., 2013)に関するプレスリリース, Nov. 2013
• 自閉症モデルマウスの作製に関する論文(Sadakata et al., Proc. Natl. Acad. Sci. USA., 2012)に関するプレスリリース, Dec. 2012
• 「自閉症を遺伝子レベルで研究する」, Dec. 2009
• 高齢者の手脚の震え原因解明, Myself, 13 Jun. 2019, Media report
• 自閉症患者におけるCAPS2遺伝子異常に関する論文(Sadakata et al., J. Clin. Invest., 2007)に関するプレスリリース（文部科学省）, Mar. 2007
• 手足震える疾患 原因解明, Myself, 15 Jun. 2019, Paper
• 手足震える原因解明, Myself, 14 Jun. 2019, Paper
• 体の「震え」原因解明, Myself, 13 Jun. 2019, Paper
• 「震えの原因特定」群馬大が発表, Myself, 12 Jun. 2019, Internet
• 手足や頭の「震え」原因解明, Myself, 12 Jun. 2019, Paper
• 母乳中の抗体　子の脳に影響, Other than myself, 02 May 2025, Paper
• 母親抗体　子の脳に影響, Other than myself, 02 May 2025, Paper
• 母乳の抗体　子の脳に影響, Other than myself, 02 May 2025, Paper
• 母乳の抗体が子供の脳の発達に影響, Other than myself, 02 May 2025, Paper
• 母親からの抗体　子どもの脳の発達などに影響, Other than myself, 02 May 2025, Internet
• 母親の抗体　子どもの脳の発達や行動に影響, Other than myself, 03 May 2025, Media report
• マウスの母乳中の抗体　子の脳にも届くことを実証, Other than myself, 29 May 2025, Internet