Researcher Profile and Settings

Researcher

• Name

  SHIMIZU Kenta

Profile and Settings

• Name

  Shimizu, Kenta

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Department of Infectious Diseases and Host Defense, Graduate School of Medicine , Senior Assistant Professor

Education

• Apr. 2003, Mar. 2007, Gifu University, The United Graduate School of Veterinary Sciences
• Apr. 1997, Mar. 2003, Gifu University, Faculty of Agriculture, Department of Veterinary Medicine

Degree

• D.V.M., Ph.D.

Association Memberships

• JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE

Research Experience

• Oct. 2021, 9999, Gunma University, Department of Infectious Diseases and Host Defense, Graduate School of Medicine, Senior Assistant Professor, Associate prof lecturer lv
• Oct. 2008, Sep. 2021, Hokkaido University, Department of Microbiology and Immunology, Faculty of Medicine, Assistant Professor, Assistant prof lv
• Apr. 2008, Sep. 2008, The Institute of Medical Science, The University of Tokyo, Research Center for Asian Infectious Diseases, Researcher postdoc lv
• Apr. 2007, Mar. 2008, The Institute of Medical Science, The University of Tokyo, Research Center for Asian Infectious Diseases, Researcher postdoc lv

Research Activities

Research Areas

• Life sciences, Virology
• Life sciences, Veterinary medicine
• Life sciences, Laboratory animal science

Research Interests

• Zoonosis
• Virology
• Immunology
• Microbiology
• Veterinary Medicine
• Laboratory Animal Science

Published Papers

• Lanka virus, a Mus booduga-borne orthohantavirus infection-associated febrile illness in Sri Lanka., Muthusinghe DS, Senarathne P, Shimizu K, Sarathkumara Y, Nanayakkara S, Lokupathirage SMW, Wei Z, Rathnayake NS, Vijeyakumaran R, Koizumi N, Kawakami T, Koizumi A, Harada KH, Dissanayake NB, Kularathne SAM, Tsuda Y, Urata S, Arikawa J, Gamage CD, Yoshimatsu K., 2025, PLoS Negl. Trop. Dis., Scientific journal
• Characterization of quasispecies of severe fever with thrombocytopenia syndrome virus., Lokupathirage SMW, Muthusinghe DS, Sarii RS, Akanbi OA, Shimizu K, Tsuda Y, Yoshimatsu K., May 2025, J. Virol., 99, 5, e0179424, Scientific journal

  DOI
• Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung., Sugiura Y, Shimizu K, Takahashi T, Ueno S, Tanigou H, Amarbayasgalan S, Kamitani W, Dec. 2024, PLoS One, 19, 12, e0312800, Scientific journal

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• Lethal model for respiratory syncytial virus infection using C57BL/6 mice., Takahashi T, Amarbayasgalan S, Ueno S, Sugiura Y, Dorjsuren E, Shimizu K, Kamitani W., Dec. 2024, J. Virol., 98, 12, e0177224, Scientific journal

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• Eight-amino-acid sequence at the N-terminus of SARS-CoV-2 nsp1 is involved in stabilizing viral genome replication., Ueno S, Amarbayasgalan S, Sugiura Y, Takahashi T, Shimizu K, Nakagawa K, Kawabata-Iwakawa R, Kamitani W., Jul. 2024, Virology, 595, 110068, Scientific journal

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• Hantavirus infection as a risk factor for chronic kidney disease of unknown etiology (CKDu) and its prevalence in endemic areas of Sri Lanka since 2010 according to a retrospective serological analysis., Gamage CD, Nanayakkara S, Sarathkumara YD, Muthusinghe DS, Shimizu K, Arikawa J, Lokupathirage SMW, Nanayakkara N, Gunarathne L, Chandrajith R, Harada KH, Koizumi A, Yoshimatsu K., Dec. 2022, J. Med. Microbiol., 71, 12, Scientific journal

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• Pathological studies on Hantaan virus-infected mice simulating severe hemorrhagic fever with renal syndrome., Wei Z, Shimizu K, Sarii RS, Muthusinghe DS, Lokupathirage SMW, Nio-Kobayashi J, Yoshimatsu K., 13 Oct. 2022, Viruses, 2247, 14, Scientific journal

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• Serological surveillance of zoonotic pathogens in rats in markets in Bogor, Indonesia., Nuradji H, Susanti, Noor SM, Dharmayanti NI, Randusari P, Shimizu K, Hirayama K, Koizumi N, Miura K., Nov. 2022, Vector-borne Zoonotic Dis., Scientific journal

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• Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation., Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertan, Feb. 2022, Nature, 602, 7896, 300, 306, Scientific journal

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• Identification of Novel Rodent-Borne Orthohantaviruses in an Endemic Area of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka, Devinda S. Muthusinghe; Kenta Shimizu; Sithumini M. W. Lokupathirage; Zhouoxing Wei; Yomani D. Sarathkumara; G. R. Amanda Fonseka; Pavani Senarathne; Nobuo Koizumi; Tomonori Kawakami; Akio Koizumi; Chaminda Wickramasinghe; Hideki Ebihara; Keita Matsuno; Yoshimi Tsuda; Jiro Arikawa; Chandika D. Gamage; Kumiko Yoshimatsu, Oct. 2021, Viruses, 13, 10, 1984, Scientific journal

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• Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (Rattus norvegicus), Shumpei P. Yasuda; Kenta Shimizu; Takaaki Koma; Nguyen Thuy Hoa; Mai Quynh Le; Zhuoxing Wei; Devinda S. Muthusinghe; Sithumini M. W. Lokupathirage; Futoshi Hasebe; Tetsu Yamashiro; Jiro Arikawa; Kumiko Yoshimatsu, Apr. 2021, Viruses, 13, 4, 665, Scientific journal

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• Subcellular localization of nucleocapsid protein of SFTSV and its assembly into the ribonucleoprotein complex with L protein and viral RNA., Lokupathirage SMW; Tsuda Y; Ikekame K; Noda K; Kozawa F; Manzoor R; Shimizu K; Muthusinghe DS; Yoshimatsu K, Nov. 2021, Scientific Reports, 11, 1, 22977, Scientific journal

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• The Polarity of an Amino Acid at Position 1891 of Severe Fever with Thrombocytopenia Syndrome Virus L Protein Is Critical for the Polymerase Activity, Kisho Noda; Yoshimi Tsuda; Fumiya Kozawa; Manabu Igarashi; Kenta Shimizu; Jiro Arikawa; Kumiko Yoshimatsu, Jan. 2021, Viruses, 13, 1, 33, Scientific journal

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• Serological methods for detection of infection with shrew-borne hantaviruses: Thottapalayam, Seewis, Altai, and Asama viruses, Wei Z; Shimizu K; Nishigami K; Tsuda Y; Sarathukumara Y; Muthusinghe DS; Gamage CD; Granathne L; Lokupathirage SMW; Nanayakkara N; Arikawa J; Kikuchi F; Tanaka-Taya K; Suzuki M; Morikawa S; Arai S; Yoshimatsu K, Jan. 2021, Archives of Virology, 166, 1, 275, 280, Scientific journal

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• Serological evidence of Thailand orthohantavirus or antigenically related virus infection among rodents in a chronic kidney disease of unknown etiology endemic area, Girandurukotte, Sri Lanka., Lokupathirage SMW; Muthusinghe DS; Shimizu K; Nishigami K; Noda K; Tsuda Y; Sarathkumara YD; Gunawardana S; Arikawa J; Gamage CD; Yoshimatsu K, Nov. 2019, Vecror Borne Zoonotic Dis., 19, 11, 859, 866, Scientific journal
• Exposure to hantavirus is a risk factor associated with kidney diseases in Sri Lanka: A cross sectional study., Sarathkumara YD; Gamage CD; Lokupathirage SMW; Muthusinghe DS; Nanayakkara N; Gunarathne L; Shimizu K; Tsuda Y; Arikawa J; Yoshimatsu K, Jul. 2019, Viruses, 11, 700, Scientific journal
• Thailand orthohantavirus infection in patients with chronic kidney disease of unknown aetiology in Sri Lanka., Yoshimatsu K; Gamage CD; Sarathkumara YD; Kulendiran T; Muthusinghe DS; Nanayakkara N; Gunarathne L; Shimizu K; Tsuda Y; Arikawa J, Jan. 2019, Archives of virology, 164, 1, 267, 271, Scientific journal
• Involvement of CD8+ T cells in the development of renal hemorrhage in a mouse model of hemorrhagic fever with renal syndrome, Kenta Shimizu; Kumiko Yoshimatsu; Midori Taruishi; Yoshimi Tsuda; Jiro Arikawa, 01 Jun. 2018, Archives of Virology, 163, 6, 1577, 1584, Scientific journal

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• Targeting of severe fever with thrombocytopenia syndrome virus structural proteins to the ERGIC (endoplasmic reticulum Golgi intermediate compartment) and Golgi complex , Tapiwa LUNDU; Yoshimi TSUDA; Ryo ITO; Kenta SHIMIZU; Shintaro KOBAYASHI; Kentaro YOSHII; Kumiko YOSHIMATSU; Jiro ARIKAWA; Hiroaki KARIWA, 2018, Biomedical Research, 39, 1, 27, 38, Scientific journal

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• Evidence of infection with Leptospira interrogans and spotted fever group rickettsiae among rodents in an urban area of Osaka City, Japan, Kenta Shimizu; Rie Isozumi; Kazutoshi Takami; Isao Kimata; Kanae Shiokawa; Kumiko Yoshimatsu; Yoshimi Tsuda; Sanae Nishio; Jiro Arikawa, Jul. 2017, JOURNAL OF VETERINARY MEDICAL SCIENCE, 79, 7, 1261, 1263, Scientific journal

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• Establishment of Subclones of the Severe Fever with Thrombocytopenia Syndrome Virus YG1 Strain Selected Using Low pH-Dependent Cell Fusion Activity, Sanae Nishio; Yoshimi Tsuda; Ryo Ito; Kenta Shimizu; Kumiko Yoshimatsu; Jiro Arikawa, Jul. 2017, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70, 4, 388, 393, Scientific journal

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• Antibody detection from Middendorf's vole (Microtus middendorffii) against Tula virus captured in Mongolia, Kumiko Yoshimatsu; Satoru Arai; Kenta Shimizu; Yoshimi Tsuda; Bazartseren Boldgiv; Bazartseren Boldbaatar; Erdenebaatar Sergelen; Dagvatseren Ariunzaya; Orsoo Enkhmandal; Sukhbaatar Tuvshintugs; Shigeru Morikawa; Jiro Arikawa, Feb. 2017, JAPANESE JOURNAL OF VETERINARY RESEARCH, 65, 1, 39, 44, Scientific journal

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• Appearance of renal hemorrhage in adult mice after inoculation of patient-derived hantavirus, Kenta Shimizu; Takaaki Koma; Kumiko Yoshimatsu; Yoshimi Tsuda; Yuji Isegawa; Jiro Arikawa, Jan. 2017, VIROLOGY JOURNAL, 14, 1, 13, Scientific journal

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• The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity, Yoshimi Tsuda; Manabu Igarashi; Ryo Ito; Sanae Nishio; Kenta Shimizu; Kumiko Yoshimatsu; Jiro Arikawa, 2017, BIOMEDICAL RESEARCH-TOKYO, 38, 2, 89, 97, Scientific journal

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• Epizootiological study of rodent-borne hepatitis E virus HEV-C1 in small mammals in Hanoi, Vietnam, Satomu Obana; Kenta Shimizu; Kumiko Yoshimatsu; Futoshi Hasebe; Kozue Hotta; Rie Isozumi; Hoa Thuy Nguyen; Mai Quynh Le; Tetsu Yamashiro; Yoshimi Tsuda; Jiro Arikawa, Jan. 2017, JOURNAL OF VETERINARY MEDICAL SCIENCE, 79, 1, 76, 81, Scientific journal

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• Serological evidence of infection with rodent-borne hepatitis E virus HEV-C1 or antigenically related virus in humans, Kenta Shimizu; Sugihiro Hamaguchi; Cuong Chi Ngo; Tian-Cheng Li; Shuji Ando; Kumiko Yoshimatsu; Shumpei P. Yasuda; Takaaki Koma; Rie Isozumi; Yoshimi Tsuda; Hiromi Fujita; Thuy Thanh Pham; Mai Quynh Le; Anh Duc Dang; Tuan Quang Nguyen; Lay-Myint Yoshida; Koya Ariyoshi; Jiro Arikawa, Nov. 2016, JOURNAL OF VETERINARY MEDICAL SCIENCE, 78, 11, 1677, 1681, Scientific journal

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• Quantitative Analysis of the Microtubule Interaction of Rabies Virus P3 Protein: Roles in Immune Evasion and Pathogenesis, Aaron Brice; Donna R. Whelan; Naoto Ito; Kenta Shimizu; Linda Wiltzer-Bach; Camden Y. Lo; Danielle Blondel; David A. Jans; Toby D. M. Bell; Gregory W. Moseley, Sep. 2016, SCIENTIFIC REPORTS, 6, 33493, Scientific journal

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• Evaluation of truncated LipL32 expressed by Escherichia coli and Pichia pastoris for serodiagnosis of Leptospira infection in rodents, Kanae Shiokawa; Chandika D. Gamage; Nobuo Koizumi; Yoshihiro Sakoda; Kenta Shimizu; Yoshimi Tsuda; Kumiko Yoshimatsu; Jiro Arikawa, Feb. 2016, JOURNAL OF VETERINARY MEDICAL SCIENCE, 78, 2, 221, 230, Scientific journal

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• Prevalence and Phylogenetic Analysis of Orientia tsutsugamushi in Small Mammals in Hanoi, Vietnam, Kozue Hotta; Hang T. T. Pham; Huong T. Hoang; Tu C. Trang; Thuy N. Vu; Trang T. H. Ung; Kenta Shimizu; Jiro Arikawa; Akio Yamada; Hoa T. Nguyen; Hang L. K. Nguyen; Mai T. Q. Le; Daisuke Hayasaka, Feb. 2016, VECTOR-BORNE AND ZOONOTIC DISEASES, 16, 2, 96, 102, Scientific journal

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• Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam, Sugihiro Hamaguchi; Ngo Chi Cuong; Doan Thu Tra; Yen Hai Doan; Kenta Shimizu; Nguyen Quang Tuan; Lay-Myint Yoshida; Le Quynh Mai; Dang Duc-Anh; Shuji Ando; Jiro Arikawa; Christopher M. Parry; Koya Ariyoshi; Pham Thanh Thuy, May 2015, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 92, 5, 972, 978, Scientific journal

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• Distinct genetic characteristics of Sri Lankan Rattus and Bandicota (Murinae, Rodentia) inferred frommitochondrial and nuclear markers, Shumpei P. Yasuda; Chandika D. Gamage; Nobuo Koizumi; Sanae Nishio; Rie Isozumi; Kenta Shimizu; Takaaki Koma; Takako Amada; Hitoshi Suzuki; Kumiko Yoshimatsu; Jiro Arikawa, 01 Sep. 2014, Genes and Genetic Systems, 89, 2, 71, 80, Scientific journal

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• Neutrophil Depletion Suppresses Pulmonary Vascular Hyperpermeability and Occurrence of Pulmonary Edema Caused by Hantavirus Infection in C.B-17 SCID Mice, Takaaki Koma; Kumiko Yoshimatsu; Noriyo Nagata; Yuko Sato; Kenta Shimizu; Shumpei P. Yasuda; Takako Amada; Sanae Nishio; Hideki Hasegawa; Jiro Arikawa, Jul. 2014, JOURNAL OF VIROLOGY, 88, 13, 7178, 7188, Scientific journal

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• Development of an immunochromatography strip test based on truncated nucleocapsid antigens of three representative hantaviruses, Takako Amada; Kumiko Yoshimatsu; Takaaki Koma; Kenta Shimizu; Chandika D. Gamage; Kanae Shiokawa; Sanae Nishio; Clas Ahlm; Jiro Arikawa, May 2014, VIROLOGY JOURNAL, 11, 1, 87, Scientific journal

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• Role of nucleocapsid protein of hantaviruses in intracellular traffic of viral glycoproteins, Kenta Shimizu; Kumiko Yoshimatsu; Takaaki Koma; Shumpei P. Yasuda; Jiro Arikawa, 26 Dec. 2013, Virus Research, 178, 2, 349, 356, Scientific journal

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• Rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats, Takako Arnada; Kumiko Yoshimatsu; Shumpei P. Yasuda; Kenta Shimizu; Takaaki Koma; Nobuhito Hayashimoto; Chandika D. Gamage; Sanae Nishio; Akira Takakura; Jiro Arikawa, Oct. 2013, JOURNAL OF VIROLOGICAL METHODS, 193, 1, 42, 49, Scientific journal

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• A survey of rodent-borne pathogens carried by wild Rattus spp. in Northern Vietnam, T. Koma; K. Yoshimatsu; S. P. Yasuda; T. Li; T. Amada; K. Shimizu; R. Isozumi; L. T.Q. Mai; N. T. Hoa; V. Nguyen; T. Yamashiro; F. Hasebe; J. Arikawa, Sep. 2013, Epidemiology and Infection, 141, 9, 1876, 1884, Scientific journal

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• Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia, Ima-Nurisa Ibrahim; Kenta Shimizu; Kumiko Yoshimatsu; Andre Yunianto; Ervi Salwati; Shumpei P. Yasuda; Takaaki Koma; Rika Endo; Jiro Arikawa, Aug. 2013, JOURNAL OF VETERINARY MEDICAL SCIENCE, 75, 8, 1003, 1008, Scientific journal

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• Novel serological tools for detection of Thottapalayam virus, a Soricomorpha-borne hantavirus, Mathias Schlegel; Erdenesaikhan Tegshduuren; Kumiko Yoshimatsu; Rasa Petraityte; Kestutis Sasnauskas; Baerbel Hammerschmidt; Robert Friedrich; Marc Mertens; Martin H. Groschup; Satoru Arai; Rika Endo; Kenta Shimizu; Takaaki Koma; Shumpei Yasuda; Chiaki Ishihara; Rainer G. Ulrich; Jiro Arikawa; Bernd Koellner, Nov. 2012, ARCHIVES OF VIROLOGY, 157, 11, 2179, 2187, Scientific journal

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• Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection, Takaaki Koma; Kumiko Yoshimatsu; Midori Taruishi; Daisuke Miyashita; Rika Endo; Kenta Shimizu; Shumpei P. Yasuda; Takako Amada; Takahiro Seto; Ryo Murata; Haruka Yoshida; Hiroaki Kariwa; Ikuo Takashima; Jiro Arikawa, Oct. 2012, JOURNAL OF VIROLOGICAL METHODS, 185, 1, 74, 81, Scientific journal

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• Studies on Hantavirus Infection in Small Mammals Captured in Southern and Central Highland Area of Vietnam, Vu Dinh Luan; Kumiko Yoshimatsu; Rika Endo; Midori Taruishi; Vo Thi Huong; Dang Tuan Dat; Pham Cong Tien; Kenta Shimizu; Takaaki Koma; Shumpei P. Yasuda; Le Nhi; Vu Thi Que Huong; Jiro Arikawa, Sep. 2012, JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 9, 1155, 1162, Scientific journal

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• bla(NDM-1)-positive Klebsiella pneumoniae from Environment, Vietnam, Rie Isozumi; Kumiko Yoshimatsu; Tetsu Yamashiro; Futoshi Hasebe; Binh Minh Nguyen; Tuan Cuong Ngo; Shumpei P. Yasuda; Takaaki Koma; Kenta Shimizu; Jiro Arikawa, Aug. 2012, EMERGING INFECTIOUS DISEASES, 18, 8, 1383, 1385, Scientific journal

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• The N-terminus of the Montano virus nucleocapsid protein possesses broadly cross-reactive conformation-dependent epitopes conserved in rodent-borne hantaviruses, Ngonda Saasa; Haruka Yoshida; Kenta Shimizu; Cornelio Sanchez-Hernandez; Maria de Lourdes Romero-Almaraz; Takaaki Koma; Takahiro Sanada; Takahiro Seto; Kentaro Yoshii; Celso Ramos; Kumiko Yoshimatsu; Jiro Arikawa; Ikuo Takashima; Hiroaki Kariwa, Jun. 2012, VIROLOGY, 428, 1, 48, 57, Scientific journal

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• Application of Truncated Nucleocapsid Protein (N) for Serotyping ELISA of Murinae-Associated Hantavirus Infection in Rats, Shumpei P. Yasuda; Kumiko Yoshimatsu; Takaaki Koma; Kenta Shimizu; Rika Endo; Rie Isozumi; Jiro Arikawa, Feb. 2012, JOURNAL OF VETERINARY MEDICAL SCIENCE, 74, 2, 215, 219, Scientific journal

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• Amino Acid Substitution at Position 95 in Rabies Virus Matrix Protein Affects Viral Pathogenicity, Naoto Ito; Tetsuo Mita; Kenta Shimizu; Yuki Ito; Tatsunori Masatani; Keisuke Nakagawa; Satoko Yamaoka; Masako Abe; Kota Okadera; Nobuyuki Minamoto; Makoto Sugiyama, Oct. 2011, JOURNAL OF VETERINARY MEDICAL SCIENCE, 73, 10, 1363, 1366, Scientific journal

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• The nucleoprotein and matrix protein segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs, Kenta Shimizu; Chengjun Li; Yukiko Muramoto; Shinya Yamada; Jiro Arikawa; Hualan Chen; Yoshihiro Kawaoka, Jul. 2011, JOURNAL OF GENERAL VIROLOGY, 92, 7, 1645, 1649, Scientific journal

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• Amino acids at positions 273 and 394 in rabies virus nucleoprotein are important for both evasion of host RIG-I-mediated antiviral response and pathogenicity, Tatsunori Masatani; Naoto Ito; Kenta Shimizu; Yuki Ito; Keisuke Nakagawa; Masako Abe; Satoko Yamaoka; Makoto Sugiyama, Jan. 2011, VIRUS RESEARCH, 155, 1, 168, 174, Scientific journal

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• Different cross-reactivity of human and rodent sera to Tula virus and Puumala virus, Erdenesaikhan Tegshduuren; Kumiko Yoshimatsu; Midori Taruishi; Rika Endo; Kenta Shimizu; Takaaki Koma; Shumpei P. Yasuda; Hiroaki Kariwa; Jiro Arikawa; Chiaki Ishihara, Dec. 2010, COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 33, 6, E67, E73, Scientific journal

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• Role of Interferon Antagonist Activity of Rabies Virus Phosphoprotein in Viral Pathogenicity, Naoto Ito; Gregory W. Moseley; Danielle Blondel; Kenta Shimizu; Caitlin L. Rowe; Yuki Ito; Tatsunori Masatani; Keisuke Nakagawa; David A. Jans; Makoto Sugiyama, Jul. 2010, JOURNAL OF VIROLOGY, 84, 13, 6699, 6710, Scientific journal

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• Truncated Hantavirus Nucleocapsid Proteins for Serotyping Sin Nombre, Andes, and Laguna Negra Hantavirus Infections in Humans and Rodents, Takaaki Koma; Kumiko Yoshimatsu; Noemi Pini; David Safronetz; Midori Taruishi; Silvana Levis; Rika Endo; Kenta Shimizu; Shumpei P. Yasuda; Hideki Ebihara; Heinz Feldmann; Delia Enria; Jiro Arikawa, May 2010, JOURNAL OF CLINICAL MICROBIOLOGY, 48, 5, 1635, 1642, Scientific journal

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• Rabies Virus Nucleoprotein Functions To Evade Activation of the RIG-I-Mediated Antiviral Response, Tatsunori Masatani; Naoto Ito; Kenta Shimizu; Yuki Ito; Keisuke Nakagawa; Yoshiharu Sawaki; Hiroyuki Koyama; Makoto Sugiyama, Apr. 2010, JOURNAL OF VIROLOGY, 84, 8, 4002, 4012, Scientific journal

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• Molecular Epidemiological and Serological Studies of Hantavirus Infection in Northern Vietnam, Thua Thang Truong; Kumiko Yoshimatsu; Koichi Araki; Byoung-Hee Lee; Ichiro Nakamura; Rika Endo; Kenta Shimizu; Shumpei P. Yasuda; Takaaki Koma; Midori Taruishi; Megumi Okumura; Uyen Ninh Truong; Jiro Arikawa, Oct. 2009, JOURNAL OF VETERINARY MEDICAL SCIENCE, 71, 10, 1357, 1363, Scientific journal

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• Amino acid at position 95 of the matrix protein is a cytopathic determinant of rabies virus, Tetsuo Mita; Kenta Shimizu; Naoto Ito; Kentaro Yamada; Yuki Ito; Makoto Sugiyama; Nobuyuki Minamoto, Oct. 2008, VIRUS RESEARCH, 137, 1, 33, 39, Scientific journal

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• Involvement of nucleoprotein, phosphoprotein, and matrix protein genes of rabies virus in virulence for adult mice, Kenta Shimizu; Naoto Ito; Tetsuo Mita; Kentaro Yamada; Junji Hosokawa-Muto; Makoto Sugiyama; Nobuyuki Minamoto, Feb. 2007, VIRUS RESEARCH, 123, 2, 154, 160, Scientific journal

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• Characterization of recombinant rabies virus carrying double glycoprotein genes, J Hosokawa-Muto; N Ito; K Yamada; K Shimizu; M Sugiyama; N Minamoto, 2006, MICROBIOLOGY AND IMMUNOLOGY, 50, 3, 187, 196, Scientific journal

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• Sensitivity of rabies virus to type I interferon is determined by the phosphoprotein gene, Kenta Shimizu; Naoto Ito; Makoto Sugiyama; Nobuyuki Minamoto, 2006, MICROBIOLOGY AND IMMUNOLOGY, 50, 12, 975, 978, Scientific journal
• Characterization of M gene-deficient rabies virus with advantages of effective immunization and safety as a vaccine strain, N Ito; M Sugiyama; K Yamada; K Shimizu; M Takayama-Ito; J Hosokawa; N Minamoto, 2005, MICROBIOLOGY AND IMMUNOLOGY, 49, 11, 973, 981, Scientific journal
• Establishment of a new reverse genetics system for respiratory syncytial virus under the control of RNA polymerase II, Takahashi, Tatsuki;Ueno, Shiori;Sugiura, Yoshiro;Shimizu, Kenta;Kamitani, Wataru, Sep. 2023, Microbiol Immunol, 67, 9, 413, 421, Scientific journal

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Presentations

• 新規に分離したウシコロナウイルスの同定, 杉浦嘉郎、鈴木亨、清水健太、高橋龍樹、Sodbayasgalan Amarbayasgalan、Enkhjin Dorjsuren、神谷亘, 第167回日本獣医学会学術集会, Sep. 2024, Japanese, Japan, Domestic conference
• A new mouse model for respiratory syncytial virus infection, Takahashi T, Ueno S, Sugiura Y, Amarbayasgalan S, Shimizu K, Kamitani W, The 22nd Awaji International Forum on Infection and Immunity, Sep. 2024, English, Kyoto, Japan, International conference
• A new mouse-adapted strain of respiratory syncytial virus, Takahashi T, Ueno S, Sugiura Y, Amarbayasgalan S, Shimizu K, Kamitani W, 43rd Annual Meeting of the American Society for Virology, Jun. 2024, English, Ohio, United States, International conference
• ヒトコロナウイルスOC43のマウスにおける増殖性の解析, 清水健太、Enkhjin Dorjsuren、高橋龍樹、杉浦嘉郎、上野栞、Sodbayasgalan Amarbayasgalan、神谷亘, 第71回日本ウイルス学会学術集会, 04 Nov. 2024, 04 Nov. 2024, 06 Nov. 2024, Japanese, Japan, Domestic conference
• SARS-CoV-2変異株のORF1ab領域がウイルス複製に及ぼす影響, 杉浦嘉郎、清水健太、高橋龍樹、Sodbayasgalan Amarbayasgalan、Enkhjin Dorjsuren、神谷亘, 第71回日本ウイルス学会学術集会, Nov. 2024, 04 Nov. 2024, 06 Nov. 2024, Japanese, Japan, Domestic conference
• RSウイルス感染症の病態を再現する新たな動物モデル, 高橋龍樹、Sodbayasgalan Amarbayasgalan、杉浦嘉郎、上野栞、Enkhjin Dorjsuren、清水健太、神谷亘, 第71回日本ウイルス学会学術集会, Nov. 2024, 04 Nov. 2024, 06 Nov. 2024, Japanese, Japan, Domestic conference
• Analyses of bovine RS virus replication in human-derived cells using recombinant reporter, Amarbayasgalan S, Takahashi T, Sugiura Y, Ueno S, Dorjsuren E, Shimizu K, Kamitani W, 第71回日本ウイルス学会学術集会, Nov. 2024, 04 Nov. 2024, 06 Nov. 2024, English, Japan, Domestic conference
• RSウイルス流行株の分子病態を解明するためのリバースジェネティクス法の確立, 高橋龍樹, 上野栞, 杉浦嘉郎, 清水健太, Sodbayasgalan Amarbayasgalan, 神谷亘, 第46回日本分子生物学会年会, Dec. 2023, Japanese, Japan, Domestic conference
• SFTSV日本分離株YG1から検出されたGPおよびL蛋白上の変異の解析：Quasipeciesの形成, 津田祥美, Sithumini M.W. Lokupathirage, Emmanuel Kodua, 清水健太, Devinda S. Muthusinghe, 吉松組子, 第70回日本ウイルス学会学術集会, Sep. 2023, Japanese, Japan, Domestic conference
• SARS-CoV-2 nsp5における複製に重要なアミノ酸配列の決定, 杉浦 嘉郎, 上野 栞, Sodbayasgalan Amarbayasgalan, 高橋 龍樹, 清水 健太, 神谷 亘, 第70回日本ウイルス学会学術集会, Sep. 2023, Japanese, Japan, Domestic conference
• SARS-CoV2のnsp2におけるアミノ酸P624/N625がウイルス複製に与える影響, 上野栞、高橋龍樹、清水健太、杉浦嘉郎、Amarbayasgalan Sodbayasgalan、神谷亘, 第70回日本ウイルス学会学術集会, Sep. 2023, Japanese, Japan, Domestic conference
• RSウイルス実験室株の高い転写複製能を活用した臨床分離株のリバースジェネティクス法, 高橋龍樹, 上野栞, 杉浦嘉郎, 清水健太, Sodbayasgalan Amarbayasgalan, 神谷亘, 第70回日本ウイルス学会学術集会, Sep. 2023, Japanese, Japan, Domestic conference
• ウシRSウイルスの新たなリバースジェネティクス法の確立, 高橋龍樹, Sodbayasgalan Amarbayasgalan, 上野栞, 杉浦嘉郎, 清水健太, 神谷亘, 第166回日本獣医学会学術集会, Sep. 2023, Japanese, Japan, Domestic conference
• Hantavirus infection as a risk factor for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka, Kumiko Yoshimatsu, Devinda S. Muthusinghe, Pavani Senarathne, Shaanika Nanayakkara, Sithumini M.W. Lokupathirage, Kouji H. Harada, Akio Koizumi, Kenta Shimizu, Jiro Arikawa, Shuzo Urata, Chandika Gamage, International Conference on Hantaviruses 2023, Jun. 2023, English, Seoul, Korea, Republic of, International conference
• Identification of a cyclin-dependent kinase inhibitor that suppresses SARS-CoV-2 replication, Kenta Shimizu, Shiori Ueno, Tatsuki Takahashi, Rigel Suzuki, Yoshimi Tsuda, Yoshiro Sugiura, Wataru Kamitani, Takasuke Fukuhara, 42nd Annual Meeting American Society for Virology, Jun. 2023, English, Athens, Georgia, United States, International conference
• スリランカ原因不明慢性腎臓病流行地から検出されたハンタウイルスの抗原性の解析, 吉松 組子、Muthusinghe Devinda、清水 健太、Lokpathirage Sithumini、危 卓行、Senarathne Pavani、Gamage Chandika, 第165回日本獣医学会学術集会, Sep. 2022, Japanese, Japan, Domestic conference
• Reverse genetics approaches for severe fever with thrombocytopenia syndrome virus, YG1 strain; characterization of subclones., Sithumini M.W. Lokupathirage, Kenta Shimizu, Yoshimi Tsuda, Devinda S. Muthusinghe, Kumiko Yoshimatsu, the 41st Annual Meeting of the American Society for Virology, Jul. 2022, English, United States, International conference
• Characterization of severe fever of thrombocytopenia virus (SFTSV) YG1 strain quasi-species using reverse genetics approaches., Sithumini Madubashini Wimalasiri Lokupathirage, Kenta Shimizu, Yoshimi Tsuda, Devinda S. Muthusinghe, Kumiko Yoshimatsu, 第69回日本ウイルス学会学術集会, 15 Nov. 2022, 13 Nov. 2022, 15 Nov. 2022, English, Japan, Domestic conference
• HiBiT発現ヒト RSウイルスの確立, 高橋 龍樹、上野 栞、杉浦 嘉郎、清水 健太、神谷 亘, 第69回日本ウイルス学会学術集会, 13 Nov. 2022, 13 Nov. 2022, 15 Nov. 2022, Japanese, Japan, Domestic conference
• 腎症候性出血熱の病原性解析：外被糖タンパク上の単一変異 E417Kはマウスモデルにおいて病原性を変化させる, 危 卓行、清水 健太、Kodua Emmanuel、小林 純子、Lokupathirage Sithumini、Muthusinghe Devinda、吉松 組子, 第69回日本ウイルス学会学術集会, 13 Nov. 2022, 13 Nov. 2022, 15 Nov. 2022, English, Japan, Domestic conference
• SARS-CoV-2の細胞内複製を抑制するキナーゼ阻害剤の同定, 清水 健太、上野 栞、鈴木 理滋、津田 祥美、高橋 龍樹、杉浦 嘉郎、神谷 亘、福原 崇介, 第69回日本ウイルス学会学術集会, 13 Nov. 2022, 13 Nov. 2022, 15 Nov. 2022, Japanese, Japan, Domestic conference
• SARS-CoV-2の nsp1-HiBiT組換えウイルスの作出の試み, 上野 栞、高橋 龍樹、清水 健太、杉浦 嘉郎、神谷 亘, 第69回日本ウイルス学会学術集会, 13 Nov. 2022, 13 Nov. 2022, 15 Nov. 2022, Japanese, Japan, Domestic conference
• Understanding of RNP complex formation of SFTSV through subcellular localization of nucleocapsid and L proteins, Sithumini Madubashini Lokupathirage, Yoshimi Tsuda, Kisho Noda, Kenta Shimizu, Devinda Muthusinghe, Kumiko Yoshimatsu, 第６８回日本ウイルス学会学術集会, Nov. 2021, English
• Roles of TIM protein family molecules on pathogenicity of Hantaan virus in mice model, Zhuoxing Wei, Kenta Shimizu, Yoshimi Tsuda, Kumiko Yoshimatsu, 第６８回日本ウイルス学会学術集会, Nov. 2021, English
• A novel neutralization test using mutant and chimeric viruses with spike proteins derived from SARS-CoV-2 variants, 鈴木理滋、森岡佑平、伊藤駿、鳥居志保、小林展大、清水健太、小野慎子、冨山貴央、吉住朋晴、松浦善治、福原崇介, 第６８回日本ウイルス学会学術集会, Nov. 2021, English
• Detection of human infections from a novel Mus-borne hantavirus in chronic kidney disease of unknown etiology (CKDu) hotspots in Sri Lanka, Devinda S. Muthusinghe, Kenta Shimizu, Sithumini M. W. Lokupathirage, Zhuoxing Wei, Keita Matsuno, Kumiko Yoshimatsu, 第６８回日本ウイルス学会学術集会, Nov. 2021, English
• Investigation of GC content in HCV infection, 森岡佑平、鈴木理滋、小林展大、伊藤駿、清水健太、松浦善治、福原崇介, 第６８回日本ウイルス学会学術集会, Nov. 2021, English
• Roles of TIM protein family molecules on pathogenicity of Hantaan virus in mice, Wei Zhuoxing, Kenta Shimizu, Yoshimi Tsuda, Kumiko Yoshimatsu, The 40th Annual Meeting of the American Society for Virology, Jul. 2021, English, International conference
• Identification of novel rodent-borne hantaviruses in an endemic area of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka, Devinda S. Muthusinghe, Kenta Shimizu, Sithumini M. W. Lokupathirage, Zhuoxing Wei, G. R. Amanda Fonseka, Pavani Senarathne, Chaminda Wickramasinghe, Hideki Ebihara, Keita Matsuno et al., The 39th Annual Meeting of the American Society for Virology, Jun. 2020, English, International conference
• Identification of a novel Mus-borne hantavirus, Lanka virus, in endemic area of chronic kidney disease of unknown etiology in Sri Lanka, Devinda S. Muthusinghe, Kenta Shimizu, Sithumini M. W. Lokupathirage, Yomani D. Sarathkumara, Hideki Ebihara, Keita Matsuno, Yoshimi Tsuda, Jiro Arikawa, Chandika D. Gamage, Kumiko Yoshimatsu, 第６７回日本ウイルス学会学術集会, Oct. 2019, English
• Development of serodiagnostic method of Soricomorpha-borne hantaviruses, Thottapalayam, Asama, Seewis and Altai viruses, Wei Zhuoxing, Kenta Shimizu, Kumpei Nishigami, Yoshimi Tsuda, Chandika D. Gamage, Jiro Arikawa, Satoru Arai, Kumiko Yoshimatsu, 第67回日本ウイルス学会学術集会, Oct. 2019, English
• 重症熱性血小板減少症候群ウイルスの粒子形成における核蛋白質の細胞内局在解析, 池亀広大、津田祥美、清水健太、苅和宏明、有川二郎、吉松組子, 第６７回日本ウイルス学会学術集会, Oct. 2019, Japanese
• A single amino acid change in SARS-CoV-2 nsp5 reduces viral enzymatic activity and pathology in the lung of infected mice, Sugiura Y, Ueno S, Takahashi T, Shimizu K, Amarbayasgalan S, Kamitani W, 43rd Annual Meeting of the American Society for Virology, Jun. 2024, English, Ohio, United States, International conference
• T25 amino acid mutation in SARS-CoV-2 nsp5 reduces the symptoms of pneumonia in infected mice, Sugiura Y, Ueno S, Takahashi T, Shimizu K, Amarbayasgalan S, Dorjsuren E, Kamitani W, The 22nd Awaji International Forum on Infection and Immunity, Sep. 2024, English, Kyoto, Japan, International conference
• SARS-CoV-2変異株のORF1ab領域内のアミノ酸変異によるウイルス増殖の違い, 杉浦嘉郎, 高橋龍樹, 清水健太, Sodbayasgalan Amarbayasgalan, Enkhjin Dorjsuren, 神谷亘, 第47回日本分子生物学会年会, Nov. 2024, Japanese, Japan, Domestic conference
• RS virus induces G2 phase cell cycle arrest in Hela Fucci (CA) 2 cells, Tao X, Takahashi T, Amarbayasgalan S, Sugiura Y, Shimizu K, Dorjsuren E, Li Y, Kamitani W, 第71回日本ウイルス学会学術集会, Nov. 2024, 04 Nov. 2024, 06 Nov. 2024, English, Japan, Domestic conference

Awards

• Jul. 2019
• JVMS Award (2016), Shimizu K;Hamaguchi S;Ngo CC;Li TC;Ando S;Yoshimatsu K;Yasuda SP;Koma T;Isozumi R;Tsuda Y;Fujita H;Pham TT;Le MQ;Dang AD;Nguyen TQ;Yoshida LM;Ariyoshi K;Arikawa J, Serological evidence of infection with rodent-borne hepatitis E virus HEV-C1 or antigenically related virus in humans, The Japanese Society of Veterinary Science, Sep. 2017

Research Projects

• Apr. 2023, Mar. 2026, Principal investigator, Competitive research funding, 23K06569
• Apr. 2023, Mar. 2026, Coinvestigator, Competitive research funding
• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Hokkaido University, Apr. 2020, Mar. 2024, Principal investigator, 20K07510
• Japan Agency for Medical Research and Development, Research Program on Emerging and Re-emerging Infectious Diseases, Hokkaido University, Jan. 2021, Mar. 2022, Coinvestigator
• Apr. 2019, Mar. 2022, Coinvestigator
• Apr. 2019, Mar. 2020, Coinvestigator
• SHIMIZU Kenta, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2016, Mar. 2020, Principal investigator
• SHIMIZU Kenta, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2014, Mar. 2017, Principal investigator
• SHIMIZU Kenta, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Apr. 2012, Mar. 2015, Principal investigator
• SHIMIZU Kenta, Hokkaido University Graduate School of Medicine, Support Program for Young Researcher Overseas Visits, Apr. 2012, Mar. 2013, Principal investigator
• SHIMIZU Kenta, Institute of Tropical Medicine, Nagasaki University, the Joint Usage / Research Center on Tropical Disease, Apr. 2012, Mar. 2013, Principal investigator