Researcher Profile and Settings

Researcher

• Name

  MIYOSHI Goichi

Profile and Settings

• Name

  Miyoshi, Goichi

ホームページ

• URI

  https://sites.google.com/view/goichimiyoshi/

Foreign language

• Use in presentation

  English

• Use in publication

  English

Degree

• Ph.D. (Biostudy)

Research Activities

Research Interests

• FOXG1 syndrome
• Behavior
• Neuraldevelopment
• Neurodevelopmental Disorder
• Autism Spectrum Disorder
• Mouse Genetics
• Inhibitory Neuron Development

Published Papers

• Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry., Hirofumi Asano; Masaya Arai; Aito Narita; Takayuki Kuroiwa; Mamoru Fukuchi; Yuhei Yoshimoto; Soichi Oya; Goichi Miyoshi, 15 Jan. 2025, Frontiers in cellular neuroscience, 18, 1513347, 1513347, Scientific journal

  DOI
• A novel quadrant spatial assay reveals environmental preference in mouse spontaneous and parental behaviors., Aito Narita; Hirofumi Asano; Hayato Kudo; Shigeo Miyata; Fumihiro Shutoh; Goichi Miyoshi, 10 Aug. 2024, Neuroscience research, Scientific journal

  DOI
• Developmental trajectories of GABAergic cortical interneurons are sequentially modulated by dynamic FoxG1 expression levels., Goichi Miyoshi; Yoshifumi Ueta; Yuki Yagasaki; Yusuke Kishi; Gord Fishell; Robert P Machold; Mariko Miyata, 16 Apr. 2024, Proceedings of the National Academy of Sciences of the United States of America, 121, 16, e2317783121, Scientific journal

  DOI
• Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons, Miyuki Takahashi; Takeru Nakabayashi; Naoki Mita; Xiaohua Jin; Yuta Aikawa; Kodai Sasamoto; Goichi Miyoshi; Mariko Miyata; Takafumi Inoue; Toshio Ohshima, Apr. 2022, MOLECULAR BRAIN, 15, 1, 37, 37, Scientific journal

  DOI
• FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes., Goichi Miyoshi; Yoshifumi Ueta; Akiyo Natsubori; Kou Hiraga; Hironobu Osaki; Yuki Yagasaki; Yusuke Kishi; Yuchio Yanagawa; Gord Fishell; Robert P Machold; Mariko Miyata, 18 Jun. 2021, Nature communications, 12, 1, 3773, 3773, Scientific journal

  DOI
• Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network., Pei-Shan Hou; Goichi Miyoshi; Carina Hanashima, 08 Aug. 2019, Nature communications, 10, 1, 3581, 3581, Scientific journal

  DOI
• Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes., Miyoshi G, Jan. 2019, Neuroscience research, 138, 26, 32, Scientific journal

  DOI
• Experience-dependent MeCP2 expression in the excitatory cells of mouse visual thalamus, Yuki Yagasaki; Goichi Miyoshi; Mariko Miyata, 01 May 2018, PLoS ONE, 13, 5, e0198268, Scientific journal

  DOI
• Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon, Geeta Godbole; Ashwin S. Shetty; Achira Roy; Leora D’Souza; Bin Chen; Goichi Miyoshi; Gordon Fishell; Shubha Tole, 01 Jan. 2018, Development (Cambridge), 145, 1, Scientific journal

  DOI
• Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons, Goichi Miyoshi; Allison Young; Timothy Petros; Theofanis Karayannis; Melissa McKenzie Chang; Alfonso Lavado; Tomohiko Iwano; Miho Nakajima; Hiroki Taniguchi; Z. Josh Huang; Nathaniel Heintz; Guillermo Oliver; Fumio Matsuzaki; Robert P. Machold; Gord Fishell, Sep. 2015, JOURNAL OF NEUROSCIENCE, 35, 37, 12869, 12889, Scientific journal

  DOI
• Continuous Postnatal Neurogenesis Contributes to Formation of the Olfactory Bulb Neural Circuits and Flexible Olfactory Associative Learning, Masayuki Sakamoto; Nao Ieki; Goichi Miyoshi; Daisuke Mochimaru; Hitoshi Miyachi; Tetsuya Imura; Masahiro Yamaguchi; Gord Fishell; Kensaku Mori; Ryoichiro Kageyama; Itaru Imayoshi, Apr. 2014, JOURNAL OF NEUROSCIENCE, 34, 17, 5788, 5799, Scientific journal

  DOI
• Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate, Goichi Miyoshi; Gord Fishell, Jun. 2012, NEURON, 74, 6, 1045, 1058, Scientific journal

  DOI
• A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre- and Flp-mediated recombination, Itaru Imayoshi; Kyoko Hirano; Masayuki Sakamoto; Goichi Miyoshi; Tetsuya Imura; Satsuki Kitano; Hitoshi Miyachi; Ryoichiro Kageyama, May 2012, NEUROSCIENCE RESEARCH, 73, 1, 85, 91, Scientific journal

  DOI
• Dynamic Changes in Interneuron Morphophysiological Properties Mark the Maturation of Hippocampal Network Activity, Camille Allene; Michel A. Picardo; Helene Becq; Goichi Miyoshi; Gord Fishell; Rosa Cossart, May 2012, JOURNAL OF NEUROSCIENCE, 32, 19, 6688, 6698, Scientific journal

  DOI
• A Resource of Cre Driver Lines for Genetic Targeting of GABAergic Neurons in Cerebral Cortex, Hiroki Taniguchi; Miao He; Priscilla Wu; Sangyong Kim; Raehum Paik; Ken Sugino; Duda Kvitsani; Yu Fu; Jiangteng Lu; Ying Lin; Goichi Miyoshi; Yasuyuki Shima; Gord Fishell; Sacha B. Nelson; Z. Josh Huang, Sep. 2011, NEURON, 71, 6, 995, 1013, Scientific journal

  DOI
• GABAergic Interneuron Lineages Selectively Sort into Specific Cortical Layers during Early Postnatal Development, Goichi Miyoshi; Gord Fishell, Apr. 2011, CEREBRAL CORTEX, 21, 4, 845, 852, Scientific journal

  DOI
• The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching, Freddy Jeanneteau; Katrin Deinhardt; Goichi Miyoshi; Anton M. Bennett; Moses V. Chao, Nov. 2010, NATURE NEUROSCIENCE, 13, 11, 1373, U103, Scientific journal

  DOI
• Genetic Fate Mapping Reveals That the Caudal Ganglionic Eminence Produces a Large and Diverse Population of Superficial Cortical Interneurons, Goichi Miyoshi; Jens Hjerling-Leffler; Theofanis Karayannis; Vitor H. Sousa; Simon J. B. Butt; James Battiste; Jane E. Johnson; Robert P. Machold; Gord Fishell, Feb. 2010, JOURNAL OF NEUROSCIENCE, 30, 5, 1582, 1594, Scientific journal

  DOI
• Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells, Ludovic Tricoire; Kenneth A. Pelkey; Michael I. Daw; Vitor H. Sousa; Goichi Miyoshi; Brian Jeffries; Bruno Cauli; Gord Fishell; Chris J. McBain, Feb. 2010, JOURNAL OF NEUROSCIENCE, 30, 6, 2165, 2176, Scientific journal

  DOI
• The integration of CGE-derived interneurons into the developing cortex Challenging the temporal matching hypothesis, Goichi Miyoshi, 2010, International Journal of Developmental Neuroscience, Scientific journal

  DOI
• Emx1-Lineage Progenitors Differentially Contribute to Neural Diversity in the Striatum and Amygdala, Laura A. Cocas; Goichi Miyoshi; Rosalind S. E. Carney; Vitor H. Sousa; Tsutomu Hirata; Kevin R. Jones; Gord Fishell; Molly M. Huntsman; Joshua G. Corbin, Dec. 2009, JOURNAL OF NEUROSCIENCE, 29, 50, 15933, 15946, Scientific journal

  DOI
• Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages, Vitor H. Sousa; Goichi Miyoshi; Jens Hjerling-Leffler; Theofailis Karayannis; Gord Fishell, Jul. 2009, CEREBRAL CORTEX, 19, I1, I10, Scientific journal

  DOI
• THE DEVELOPMENTAL GENETIC ORIGINS OF CORTICAL INTERNEURONS, Goichi Miyoshi, 2009, Journal of Neurochemistry, Scientific journal
• The requirement of Nkx2-1 in the temporal specification of cortical interneurion subtypes, Simon J. B. Butt; Vitor H. Sousa; Marc V. Fuccillo; Jens Hjerling-Leffler; Goichi Miyoshi; Shioko Kimura; Gord Fishell, Sep. 2008, NEURON, 59, 5, 722, 732, Scientific journal

  DOI
• Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic olig2-expressing precursors, Goichi Miyoshi; Simon J. B. Butt; Hirohide Takebayashi; Gord Fishell, Jul. 2007, JOURNAL OF NEUROSCIENCE, 27, 29, 7786, 7798, Scientific journal

  DOI
• Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord, James Battiste; Amy W. Helms; Euiseok J. Kim; Trisha K. Savage; Diane C. Lagace; Chitra D. Mandyam; Amelia J. Eisch; Goichi Miyoshi; Jane E. Johnson, Jan. 2007, DEVELOPMENT, 134, 2, 285, 293, Scientific journal

  DOI
• Directing neuron-specific transgene expression in the mouse CNS, Goichi Miyoshi; Gord Fishell, Oct. 2006, CURRENT OPINION IN NEUROBIOLOGY, 16, 5, 577, 584

  DOI
• Requirement of multiple basic helix-loop-helix genes for retinal neuronal subtype specification, T Akagi; T Inoue; G Miyoshi; Y Bessho; M Takahashi; JE Lee; F Guillemot; R Kageyama, Jul. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 27, 28492, 28498, Scientific journal

  DOI
• Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic Neurogenesis, G Miyoshi; Y Bessho; S Yamada; R Kageyama, Apr. 2004, JOURNAL OF NEUROSCIENCE, 24, 14, 3672, 3682, Scientific journal

  DOI
• Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm, Y Bessho; G Miyoshi; R Sakata; R Kageyama, Feb. 2001, GENES TO CELLS, 6, 2, 175, 185, Scientific journal
• The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina, T Satow; SK Bae; T Inoue; C Inoue; G Miyoshi; K Tomita; Y Bessho; N Hashimoto; R Kageyama, Feb. 2001, JOURNAL OF NEUROSCIENCE, 21, 4, 1265, 1273, Scientific journal
• Editorial: Cellular and molecular mechanisms that govern assembly, plasticity, and function of GABAergic inhibitory circuits in the mammalian brain., Yasufumi Hayano; Goichi Miyoshi; Anirban Paul; Hiroki Taniguchi, 2025, Frontiers in cellular neuroscience, 19, 1568845, 1568845, Scientific journal

  DOI
• Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons., Miyoshi Goichi;Young Allison;Petros Timothy;Karayannis Theofanis;McKenzie Chang Melissa;Lavado Alfonso;Iwano Tomohiko;Nakajima Miho;Taniguchi Hiroki;Huang Z Josh;Heintz Nathaniel;Oliver Guillermo;Matsuzaki Fumio;Machold Robert P;Fishell Gord, The Journal of neuroscience : the official journal of the Society for Neuroscience, 35, 37

  DOI
• 自閉スペクトラム症の生後発症臨界期を制御する抑制ニューロン発達機構, ;;;;;;;;, Aug. 2024, 74, 3, 245

Books etc

• 自閉スペクトラム発症の臨界期における抑制回路発達機構の解明, Oct. 2022
• 自閉スペクトラム症医療を加速する発症の臨界期および抑制回路発達機構の解明, 22 Sep. 2021, Scholarly book
• 大脳皮質介在ニューロンの発生 脳科学辞典, 20 Sep. 2020
• 自閉症関連因子FoxG1「量」が制御する回路形成機構, 20 Mar. 2018
• GABA細胞移植と脳疾患治療の大いなる可能性, 18 Mar. 2016
• 大脳皮質GABA産生インターニューロンの発生機構 ― 遺伝学的手法の展開と医療応用への大きな可能性., Dec. 2014, 1129-1136
• SfN 2013 学会参加記, 10 Feb. 2014
• 大脳皮質の発生過程における未分化なピラミダルニューロンの移動は転写因子FoxG1のダイナミックな減少および増加により制御されている, 2012

Presentations

• 非典型レットFOXG1症候群の細胞移植治療モデルが解き明かす高次機能発達機構, 三好悟一, 第67回 日本小児神経学会学術集会, 04 Jun. 2025, 04 Jun. 2025, 07 Jun. 2025, Japanese, Japan, Domestic conference
• Inhibitory Neuron Development: A Key to Understanding Social Behavior and Autism Spectrum Disorder, 三好悟一, CSHA Optical Interrogation of Neural Structure and Dynamics Underlying Behavior, 23 Apr. 2024, 21 Apr. 2025, 24 2025, English, Japan, International conference
• Early Postnatal Critical Period for Social Behavioral Circuit Development, 三好悟一, Principles of Neocortical Development and Evolution II, 15 Apr. 2025, 15 Apr. 2025, 16 Apr. 2025, English, Japan, International conference
• FOXG1症候群とその治療モデルマウスを用いた回路発達研究への取り組み, 三好悟一, レット症候群とその周辺疾患の臨床調査研究班公開シンポジウムin大阪, 22 Mar. 2025, 22 Mar. 2025, Japanese, Japan
• 自閉スペクトラム症モデルを用いた社会性回路発達機構の解明, 三好悟一, 滋賀医科大学セミナー, 13 Mar. 2025, 13 Mar. 2025, Japanese, Japan
• 自閉スペクトラム症モデルを用いた社会性回路発達のメカニズム解明, 三好悟一, 新学術創成研究機構 異分野融合セミナー, 27 Feb. 2025, 27 Feb. 2025, Japanese, Japan
• あの時の○○が、今の研究者ライフにつながっている, 三好悟一, 臨界期生物学　冬のワークショップ, 20 Feb. 2025, 20 Feb. 2025, Japanese, Japan, Domestic conference
• ASDモデルにおける抑制ニューロン発達と社会性形成機構, 三好悟一, 第19回自閉症学研究会（19th JCAR in SENDAI）, 08 Feb. 2025, 08 Feb. 0205, 09 Feb. 2025, Japanese, Japan, Domestic conference
• ASDモデルを用いた社会性発達における抑制ニューロンメカニズムの解明, 三好悟一, 鹿児島神経科学 鍋倉 淳一先生特別講演会および研究会, 17 Dec. 2024, 16 Dec. 2024, 17 Dec. 2024, Domestic conference
• An Early Postnatal Critical Period for Social Behavior Circuit Development, 三好悟一, 遺伝研研究会2024「哺乳類脳の機能的神経回路の構築メカニズム」, 12 Dec. 2024, 12 Dec. 2024, 13 Dec. 2024
• An Early Postnatal Critical Period for Social Behavior Circuit Development Miyoshi, G., 三好悟一, 第97回日本生化学会大会, 06 Nov. 2024, 06 Nov. 2024, 08 Nov. 2024, Japan, Domestic conference
• An early postnatal critical period for autism spectrum disorder-related circuit development, 三好悟一, The 10th IMCR symposium on Endocrine and Metabolism Gunma University, Institute for Molecular and Cellular Regulation (IMCR), 31 Oct. 2024, 31 Oct. 2024, 01 Nov. 2024, English, Gunma University, Japan, International conference
• 研究成果報告, 三好悟一, 第三回　FOXG1患者家族会, 13 Oct. 2024, 13 Oct. 2024, Japanese, Japan
• 自閉スペクトラム症解明と画期的治療法の開発, 三好悟一, 公益財団法人 アステラス病態代謝研究会 第54回 研究報告会, 12 Oct. 2024, 12 Oct. 2024, Japanese, Japan
• An early postnatal critical period for the development of inhibitory neurons in social circuit, 三好悟一, International Society for Developmental Neuroscience (ISDN) 2024, 24 Sep. 2024, 21 Sep. 2024, 24 Sep. 2024, English, Montpellier, France, International conference
• An early postnatal critical period for autism spectrum disorder-related circuit development, 三好悟一, College de France, 18 Sep. 2024, 18 Sep. 2024, English, College de France, France
• ASD 研究に変革をもたらす臨界期再構築戦略, 三好悟一, 文部科学省科学研究費助成金事業　学術変革A　臨界期生物学 領域班会議(オンライン), 28 Aug. 2024, 30 Aug. 2024, Japanese
• An early postnatal critical period for ASD-related GABAergic circuit development, 三好悟一, Gordon Research Conference, Neural Development, 28 Jul. 2024, 28 Jul. 2024, 04 Aug. 2024, English, Lucca (Barga), Italy, International conference
• 自閉スペクトラムの生後発症臨界期を制御する抑制ニューロン発達機構, 三好悟一, NEURO2024, 24 Jul. 2024, 24 Jul. 2024, 27 Jul. 2024, Japanese, Japan, Domestic conference
• 自閉スペクトラム症につながる脳発達過程を理解する, 三好悟一, 都医学研 第3回 都民講座, 18 Jul. 2024, 18 Jul. 2024, Japanese, Japan
• ⾃閉スペクトラム症の発症臨界期機構の解明, 三好　悟一, 第7 回包括的神経グリア研究会, 27 Jan. 2024, 27 Jan. 2024, Japanese, Japan
• Early postnatal developmental period for ASD-related social behavioral circuit formation, 三好　悟一, The 38th International Kumamoto Medical and Bioscience Symposium, 14 Dec. 2023, 14 Dec. 2023, 15 Dec. 2023, English, Japan, Domestic conference
• FOXG1最新研究, 三好　悟一, FOXG1 JAPAN会合, 16 Sep. 2023, 16 Sep. 2023, Japanese, Japan
• 自閉スペクトラム症の生後発症臨界期における回路発達メカニズムの解明, 三好　悟一, 愛知県医療療育総合センター発達障害研究所共同セミナー, 15 Sep. 2023, 15 Sep. 2023, Japan
• ASD研究に変革をもたらす臨界期再構築戦略, 三好　悟一, 文部科学省科学研究費助成金事業　学術変革（臨界期）班会議, 30 Aug. 2023, 30 Aug. 2023, Japanese, Japan
• 大脳皮質GABA抑制回路のインタクティブ形成, 三好　悟一, 第46回日本神経科学大会, 04 Aug. 2023, 01 Aug. 2023, 04 Aug. 2023, Japanese, Japan, International conference
• Early postnatal developmental period for ASD-related social behavioral circuits, 三好　悟一, 17th Biennial Meeting of the Asian-Pacific Society for Neurochemistry, 19 Jun. 2023, 19 Jun. 2023, 21 Jun. 2023, English, Marina Bay Sands, Singapore, International conference
• 自閉症スペクトラム症の発症臨界期機構の解明, 三好　悟一, 高崎健康福祉大学　薬学部セミナー, 09 May 2023, 09 May 2023, Japanese, Japan
• A critical developmental period for autism-related social behavioral cortical circuits, 三好悟一, International Symposium on Neural Development and Diseases, 16 Mar. 2023, 15 Mar. 2023, 17 Mar. 2023, English, Shiran Kaikan, Kyoto University, Japan, International conference
• 自閉スペクトラム症の発症を司る臨界期抑制回路機構の解明, 三好悟一, JASS ニューヨーク日本人理系勉強会（リモート）, 28 Oct. 2022, 28 Oct. 2022, Japanese
• 自閉スペクトラム症の発症を司る臨界期抑制回路機構の解明, 三好悟一, 名古屋大学　卓越大学院プログラム GTRセミナー, 19 Oct. 2022, 19 Oct. 2022, Japanese
• 自閉スペクトラム症モデルにおける 抑制回路発達機構の解明, 三好悟一, 大阪公立大学セミナー, 15 Jun. 2022, 15 Jun. 2022, Japanese, Japan

Industrial Property Rights

• Patent right, 特願2018-92200, 11 May 2018, P2019-195314A, 14 Nov. 2019, 特許第7123372号, 15 Aug. 2022

Academic Contribution

• Interactive assembly of the neocortical GABAergic circuits, 04 Aug. 2023, 04 Aug. 2023

Social Contribution

Social Contribution

• レット症候群とその周辺疾患の臨床調査研究班公開シンポジウムin大阪, 22 Mar. 2025, Others　(Target:　Researchers, General, Civic organization)
• 第3回FOXG1患者家族会, 13 Oct. 2024, Others　(Target:　Others)
• 都医学研 第3回 都民講座, 18 Jul. 2024　(Target:　Others)
• 第２回FOXG1患者家族会, 22 Sep. 2023, Others　(Target:　Others)
• FOXG1症候群患者家族会, 2019

Media Coverage

• 蚕が出す「きびそ」に安らぎ効果？　群馬大大学院の三好教授が発見　企業開発の壁紙に注目集まる, Other than myself, Jomo newspaper, 24 Nov. 2024, Paper
• 上毛新聞 脳とこころ 概説記事　変化し形保つ"可塑性", Myself, 26 Sep. 2022, Paper
• 上毛新聞 脳とこころ 第２章 インタビュー記事　難病支援向き合う, Myself, 03 Sep. 2022, Paper
• Critical time window flagged for autism gene's influence, Other than myself, SIMONS FOUNDATION, Spectrum News, 16 Jul. 2021, https://doi.org/10.53053/BLQG5882, Internet
• 自閉スペクトラム発症を制御する抑制回路の仕組みを解明, Other than myself, 18 Jun. 2021
• 自閉スペクトラム症の発症につながる「FOXG1」遺伝子の異常と発達期との関係を解明, Other than myself, 09 Jul. 2021, Internet