Researcher Profile and Settings

Researcher

• Name

  TAKEDA SHIGEKI

Profile and Settings

• Name

  TAKEDA, SHIGEKI

Alternate Names

• S. Takeda

Affiliation

• Gunma University
• Gunma University

Education

• Mar. 1986, Hokkaido University, Faculty of Pharmaceutical Science
• Mar. 1991, The University of Tokyo, Graduate School, Division of Engineering

Research Experience

• Gunma University

Research Activities

Research Areas

• Life sciences
• Functional Biochemistry
• Life sciences, Molecular biology

Research Interests

• Protein, Receptor, Bacteriophage, Self-assembly, interaction

Published Papers

• Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis., Shimamori Y, Pramono AK, Kitao T, Suzuki T, Aizawa SI, Kubori T, Nagai H, Takeda S, Ando H., 10 Apr. 2021

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• In vitro assessment of antitumor immune responses using tumor antigen proteins produced by transgenic silkworms, Kanae Yamada, Kei Masuda, Shota Ida, Hiroe Tada, Minori Bando, Kanako Abe, Ken-ichiro Tatematsu, Hideki Sezutsu, Tetsunari Oyama, Kazuaki Chikamatsu, Shigeki Takeda, 2021, Journal of Materials Science: Materials in Medicine
• Staphylococcal Phage in Combination with Staphylococcus Epidermidis as a Potential Treatment for Staphylococcus Aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants., Shimamori Y, Mitsunaka S, Yamashita H, Suzuki T, Kitao T, Kubori T, Nagai H, Takeda S, Ando H., 22 Dec. 2020, Viruses., Scientific journal

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• Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics, Tatsuro Kawamura; Yushi Futamura; Erchang Shang; Makoto Muroi; Petra Janning; Masayoshi Ueno; Julian Wilke; Shigeki Takeda; Yasumitsu Kondoh; Slava Ziegler; Nobumoto Watanabe; Herbert Waldmann; Hiroyuki Osada, 31 Aug. 2020, Bioscience, Biotechnology, and Biochemistry, 1, 7, Scientific journal

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• Secretory expression of thyroid hormone receptor using transgenic silkworms and its DNA binding activity., Hirofumi Nakaya; Ken-Ichiro Tatematsu; Hideki Sezutsu; Nobuo Kuwabara; Noriyuki Koibuchi; Shigeki Takeda, 05 Aug. 2020, Protein expression and purification, 105723, 105723, Scientific journal

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• Points to consider on quality risk management of biopharmaceuticals produced by transgenic silkworms, A. Ishii-Watabe; M. Tada; A. Harazono; M. Kiyoshi; K. Tatematsu; M. Tomita; T. Ohmura; T. Ichihara; H. Yamaguchi; T. Tanaka; T. Tanaka; H. Shibata; K. Yusa; Y. Sato; S. Takeda; K. Itoh; N. Kawasaki; H. Sezutsu, Dec. 2019, Pharmaceutical and Medical Device Regulatory Science
• Observation of unexpected molecular binding activity for Mu phage tail fiber chaperones., Sakai K; Iwazaki T; Yamashita E; Nakagawa A; Sakuraba F; Enomoto A; Inagaki M; Takeda S, Aug. 2019, Journal of biochemistry

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• Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres., North OI; Sakai K; Yamashita E; Nakagawa A; Iwazaki T; Buttner CR; Takeda S; Davidson AR, Aug. 2019, Nat Microbiol., 4, 10, 1645, 1653

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• Observation of unexpected molecular binding activity for Mu phage tail fiber chaperones., Sakai K; Iwazaki T; Yamashita E; Nakagawa A; Sakuraba F; Enomoto A; Inagaki M; Takeda S, Aug. 2019
• Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres., North OI; Sakai K; Yamashita E; Nakagawa A; Iwazaki T; Buttner CR; Takeda S; Davidson AR, Jun. 2019, Nature microbiology

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• GPR31 and GPR151 are activated under acidic conditions., Mashiko M; Kurosawa A; Tani Y; Tsuji T; Takeda S, May 2019, Journal of biochemistry

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• GPR31 and GPR151 are activated under acidic conditions., Mashiko M; Kurosawa A; Tani Y; Tsuji T; Takeda S, May 2019, Journal of biochemistry
• Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae., Iwasaki T; Yamashita E; Nakagawa A; Enomoto A; Tomihara M; Takeda S, May 2019
• Points to consider on quality risk management of biopharmaceuticals produced by transgenic silkworms, 武田 茂樹, 2019, Pharmaceutical and Medical Device Regulatory Science
• A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription., Ariyani W; Iwasaki T; Miyazaki W; Yu L; Takeda S; Koibuchi N, Aug. 2018, Toxicological Sciences

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• A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription., Ariyani W; Iwasaki T; Miyazaki W; Yu L; Takeda S; Koibuchi N, Aug. 2018
• Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae., Iwasaki T; Yamashita E; Nakagawa A; Enomoto A; Tomihara M; Takeda S, May 2018, Genes to cells : devoted to molecular & cellular mechanisms, 23, 7, 528, 536

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• Most of it started with T4 phage and was then taken over, Shigeki Takeda, 01 Apr. 2018, Biophysical Reviews, 10, 2, 141, 144, Scientific journal

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• Melanoma antigen family A4 protein produced by transgenic silkworms induces antitumor immune responses, Yoko Motokawa; Michifumi Kokubo; Nobuo Kuwabara; Ken-Ichiro Tatematsu; Hideki Sezutsu; Hideyuki Takahashi; Koichi Sakakura; Kazuaki Chikamatsu; Shigeki Takeda, 01 Mar. 2018, Experimental and Therapeutic Medicine, 15, 3, 2512, 2518, Scientific journal

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• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto; Aya Kurosawa; Yoshiaki Nikaido; Misaki Mashiko; Toshihiko Saheki; Nozomi Nakajima; Satoshi Kuroiwa; Michinari Otobe; Maki Ohsaki; Kazuya Tooyama; Yusuke Inoue; Nobuo Kuwabara; Osamu Kikuchi; Tadahiro Kitamura; Itaru Kojima; Yuko Nakagawa; Tamio Saito; Hiroyuki Osada; Mizuko Futahashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137, Scientific journal

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• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Toshihiro Yanai; Aya Kurosawa; Yoshiaki Nikaido; Nozomi Nakajima; Tamio Saito; Hiroyuki Osada; Ayumu Konno; Hirokazu Hirai; Shigeki Takeda, Jul. 2016, GENES TO CELLS, 21, 7, 717, 727, Scientific journal

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• 遺伝子組換えカイコの有用タンパク質生産への応用, 武田 茂樹, 2016, 72, 10

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• In vivo and in vitro evaluation of novel mu-opioid receptor agonist compounds, Yoshiaki Nikaido; Aya Kurosawa; Hitomi Saikawa; Satoshi Kuroiwa; Chiharu Suzuki; Nobuo Kuwabara; Hazime Hoshino; Hideaki Obata; Shigeru Saito; Tamio Saito; Hiroyuki Osada; Isao Kobayashi; Hideki Sezutsu; Shigeki Takeda, Nov. 2015, EUROPEAN JOURNAL OF PHARMACOLOGY, 767, 193, 200, Scientific journal

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• Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84, Yoshiaki Nikaido; Yuuta Koyama; Yasushi Yoshikawa; Toshio Furuya; Shigeki Takeda, May 2015, JOURNAL OF BIOCHEMISTRY, 157, 5, 311, 320, Scientific journal

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• カイコ利用の新時代, 武田 茂樹; 河原 豊; 粕谷 健一, Dec. 2014, 67, 12
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells., Yoshiaki Ohtsu; Yuko Nakagawa; Masahiro Nagasawa; Shigeki Takeda; Hirokazu Arakawa; Itaru Kojima, 25 Aug. 2014, Molecular and cellular endocrinology, 394, 1-2, 70, 9, Scientific journal

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• Identification of a Morphogenic Intermediate of the Bacteriophage Mu Baseplate, Nao Tsukamoto; Yuko Kanazawa; Yuzuki Shimamori; Keiko Yoshida; Shigeki Takeda, Apr. 2014, Advances in Microbiology, 4, 3
• Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion, Kenichi Harada; Eiki Yamashita; Atsushi Nakagawa; Takamitsu Miyafusa; Kouhei Tsumoto; Takashi Ueno; Yoshiharu Toyama; Shigeki Takeda, Jan. 2013, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834, 1, 284, 291, Scientific journal

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• MRGD, a MAS-related G-protein Coupled Receptor, Promotes Tumorigenisis and Is Highly Expressed in Lung Cancer, S. Nishimura; M. Uno; Y. Kaneta; K. Fukuchi; H. Nishigohri; J. Hasegawa; H. Komori H; S. Takeda; K. Enomoto; F. Nara; T. Agatsuma, Jul. 2012, PLoS One,, 7
• MRGD, a MAS-related G-protein Coupled Receptor, Promotes Tumorigenisis and Is Highly Expressed in Lung Cancer, Satoko Nishimura; Makiko Uno; Yasuyuki Kaneta; Keisuke Fukuchi; Haruyuki Nishigohri; Jun Hasegawa; Hironobu Komori; Shigeki Takeda; Katsuhiko Enomoto; Futoshi Nara; Toshinori Agatsuma, Jun. 2012, PLOS ONE, 7, 6, Scientific journal

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• Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion, K. Harada; E. Yamashita; A. Nakagawa; T. Miyafusa; K. Tsumoto; T. Ueno; Y. Toyama; S. Takeda, Apr. 2012, Biochem Biophys Acta, 1804
• Identification of Physiologically Active Substances as Novel Ligands for MRGPRD, Makiko Uno; Satoko Nishimura; Keisuke Fukuchi; Yasuyuki Kaneta; Yoko Oda; Hironobu Komori; Shigeki Takeda; Tatsuya Haga; Toshinori Agatsuma; Futoshi Nara, 2012, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, Scientific journal

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• Identification of Physiologically Active Substances as Novel Ligands for MRGPRD, Makiko Uno; Satoko Nishimura; Keisuke Fukuchi; Yasuyuki Kaneta; Yoko Oda; Hironobu Komori; Shigeki Takeda; Tatsuya Haga; Toshinori Agatsuma; Futoshi Nara, 2012, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, Scientific journal

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• 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion, Ryouta Kogure; Kazuya Toyama; Shuichi Hiyamuta; Itaru Kojima; Shigeki Takeda, Dec. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 416, 1-2, 58, 63, Scientific journal

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• 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion, R. Kogure; K. Toyama; S. Hiyamuta; I. Kojima; S. Takeda, Nov. 2011, . Biochem Biophys Res Commun., 416
• The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure, Eiki Yamashita; Atsushi Nakagawa; Junichi Takahashi; Kin-ichi Tsunoda; Seiko Yamada; Shigeki Takeda, Aug. 2011, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 67, 837, 841, Scientific journal

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• The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure, Eiki Yamashita; Atsushi Nakagawa; Junichi Takahashi; Kin-ichi Tsunoda; Seiko Yamada; Shigeki Takeda, Aug. 2011, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 67, 837, 841, Scientific journal

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• Genomic and proteomic characterization of the largeMyoviridaebacteriophage ϕTMA of the extreme thermophileThermus thermophilus, Masatada Tamakoshi; Aya Murakami; Motoki Sugisawa; Kenji Tsuneizumi; Shigeki Takeda; Toshihiko Saheki; Takashi Izumi; Toshihiko Akiba; Kaoru Mitsuoka; Hidehiro Toh; Atsushi Yamashita; Fumio Arisaka; Masahira Hattori; Tairo Oshima; Akihiko Yamagishi, May 2011, Bacteriophage, 1, 3, 152, 164, Scientific journal

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• The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein,, H. Suzuki; S. Yamada; Y. Toyama; S. Takeda, Oct. 2010, Biochim Biophys Acta,, 1804
• The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein, Hidetaka Suzuki; Seiko Yamada; Yoshiharu Toyama; Shigeki Takeda, Sep. 2010, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804, 9, 1738, 1742, Scientific journal

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• Observation of the membrane binding activity and domain structure of gpV, which comprises the tail spike of bacteriophage P2, Hidetaka Suzuki; Seiko Yamada; Yoshiharu Toyama; Shigeki Takeda, Sep. 2010, Biochim Biophys Acta, 1804, 9
• The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure, Eiki Yamashita; Atsushi Nakagawa; Junichi Takahashi; Kin-ichi Tsunoda; Seiko Yamada; Shigeki Takeda, Sep. 2010, Acta Crystallographica
• Observation of the Membrane Binding Activity and Domain Structure of gpV, Which Comprises the Tail Spike of Bacteriophage P2, Yasuhiro Kageyama; Masanori Murayama; Takashi Onodera; Seiko Yamada; Harumi Fukada; Motonori Kudou; Kouhei Tsumoto; Yoshiharu Toyama; Syunsaku Kado; Kenji Kubota; Shigeki Takeda, Oct. 2009, BIOCHEMISTRY, 48, 42, 10129, 10135, Scientific journal

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• Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system, Mizuho Kajikawa; Kaori Sasaki; Yoshitaro Wakimoto; Masaru Toyooka; Tomoko Motohashi; Tsukasa Shimojima; Shigeki Takeda; Enoch Y. Park; Katsumi Maenaka, Jul. 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385, 3, 375, 379, Scientific journal

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• Production and characterization of the recombinant human μ-opioid receptor from transgenic silkworms, Mayuko Tateno; Masaru Toyooka; Yohko Shikano; Shigeki Takeda; Nobuo Kuwabara; Hideki Sezutsu; Toshiki Tamura, Jun. 2009, The Journal of Biochemistry
• The N-Terminal Domain of GPR61, an Orphan G-Protein-Coupled Receptor, Is Essential for Its Constitutive Activity, Masaru Toyooka; Takashi Tujii; Shigeki Takeda, May 2009, JOURNAL OF NEUROSCIENCE RESEARCH, 87, 6, 1329, 1333, Scientific journal

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• The N-Terminal Domain of GPR61, an Orphan G-Protein-Coupled Receptor, Is Essential for Its Constitutive Activity, Masaru Toyooka; Takashi Tujii; Shigeki Takeda, May 2009, JOURNAL OF NEUROSCIENCE RESEARCH, 87, 6, 1329, 1333, Scientific journal

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• Efficient Silkworm Expression of Human GPCR (Nociceptin Receptor) by a Bombyx mori Bacmid DNA System, M. Kajikawa; K. Sasaki; Y. Wakimoto; M. Toyooka; T. Motohashi; T. Shimojima; S. Takeda; Y. Park; K. Maenaka, Mar. 2009, Biochem. Biophys. Res. Commun.. Biochem., 385
• Production and Characterization of the Recombinant Human -Opioid Receptor from Transgenic Silkworms, Mayuko Tateno; Masaru Toyooka; Yohko Shikano; Shigeki Takeda; Nobuo Kuwabara; Hideki Sezutsu; Toshiki Tamura, Jan. 2009, JOURNAL OF BIOCHEMISTRY, 145, 1, 37, 42, Scientific journal

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• Production and Characterization of the Recombinant Human -Opioid Receptor from Transgenic Silkworms, Tateno, Mayuko;Toyooka, Masaru;Shikano, Yohko;Takeda, Shigeki;Kuwabara, Nobuo;Sezutsu, Hideki;Tamura, Toshiki, 2009, JOURNAL OF BIOCHEMISTRY, 145, 1, 37, 42

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• Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids, Yoshinori Sasaki; Takashi Tsujii; Shigeki Takeda; Hideru Obinata; Takashi Izumi; Keiichi Yamada; Ryoichi Katakai, Dec. 2008, JOURNAL OF PEPTIDE SCIENCE, 14, 12, 1251, 1258, Scientific journal

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• Morphine is an exogenous ligand for MrgX2, a G protein-coupled receptor for cortistatin, N. Akuzawa; H. Obinata; T. Izumi; S. S. Takeda, Jan. 2008, J. Cell and Animal Biol., 2
• Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids, Yoshinori Sasaki; Takashi Tsujii; Shigeki Takeda; Hideru Obinata; Takashi Izumi; Keiichi Yamada; Ryoichi Katakai, 2008, Journal of Peptide Science, 14, 12, 1251, 1258, Scientific journal

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• Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes, Natsuyo Akuzawa; Shigeki Takeda; Masaji Ishiguro, Jun. 2007, JOURNAL OF BIOCHEMISTRY, 141, 6, 907, 916, Scientific journal

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• Structural modeling and mutation analysis of a nociceptin receptor and its ligand complexes., N. Akuzawa; S. Takeda; M. Ishiguro, May 2007, J. Biochem. (Tokyo),, 141
• Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes, Akuzawa, Natsuyo;Takeda, Shigeki;Ishiguro, Masaji, 2007, JOURNAL OF BIOCHEMISTRY, 141, 6, 907, 916

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• 5-oxo-eicosatetraenoic acid-induced chemotaxis: Identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13), D Koike; H Obinata; A Yamamoto; S Takeda; H Komori; F Nara; T Izumi; T Haga, Mar. 2006, JOURNAL OF BIOCHEMISTRY, 139, 3, 543, 549, Scientific journal

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• 5-oxo-eicosatetraenoic acid-induced chemotaxis: Identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13), D Koike; H Obinata; A Yamamoto; S Takeda; H Komori; F Nara; T Izumi; T Haga, Mar. 2006, JOURNAL OF BIOCHEMISTRY, 139, 3, 543, 549, Scientific journal

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• (book) G protein-coupled receptors; Structure,Function, and Ligand Screening Ed. by T. Haga and S. Takeda, TAKEDA SHIGEKI, Feb. 2006, CRC Press
• Inhibitory regulation of 5-oxo-ETE dependent chemotaxis by G12/13 pathways, TAKEDA SHIGEKI, Jan. 2006, J. Biochem. (Tokyo), 139, 1-7
• 味覚受容体の機能解析, 武田 茂樹, Dec. 2005
• 受容体の解析／スクリーニング, 武田 茂樹, Nov. 2005
• Structure of the central hub of bacteriophage Mu baseplate determined by X-ray crystallography of gp44, Y Kondou; D Kitazawa; S Takeda; Y Tsuchiya; E Yamashita; M Mizuguchi; K Kawano; T Tsukihara, Sep. 2005, JOURNAL OF MOLECULAR BIOLOGY, 352, 4, 976, 985, Scientific journal

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• Structure of the central hub of bacteriophage Mu baseplate determined by X-ray crystallography of gp44, TAKEDA SHIGEKI, Aug. 2005, J. Mol. Biol., 352, 976-985
• G蛋白質共役受容体機能の解析方法, 武田 茂樹, Jul. 2005
• Expression and characterization of a baseplate protein for bacteriophage Mu, gp44, D Kitazawa; S Takeda; Y Kageyama; M Tomihara; H Fukada, May 2005, JOURNAL OF BIOCHEMISTRY, 137, 5, 601, 606, Scientific journal

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• Expression and characterization of a baseplate protein for bacteriophage Mu, gp44, TAKEDA SHIGEKI, Apr. 2005, J. Biochem. (Tokyo), 137, 601-606
• Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu, Y Kondou; D Kitazawa; S Takeda; E Yamashita; M Mizuguchi; K Kawano; T Tsukihara, Jan. 2005, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 61, 104, 105, Scientific journal

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• Crystallization and preliminary X-ray analysis of gene product 44 from bacteriophage Mu, Y Kondou; D Kitazawa; S Takeda; E Yamashita; M Mizuguchi; K Kawano; T Tsukihara, Jan. 2005, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 61, 104, 105, Scientific journal

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• Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis, S Takeda; M Suzuki; T Yamada; M Kageyama; F Arisaka, Jun. 2004, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1699, 1-2, 163, 171, Scientific journal

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• Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis, S Takeda; M Suzuki; T Yamada; M Kageyama; F Arisaka, Jun. 2004, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1699, 1-2, 163, 171, Scientific journal

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• Stimulation of increases in intracellular calcium and prostaglandin E-2 generation in chinese hamster ovary cells expressing receptor G alpha(16) fusion proteins, H Suga; S Takeda; T Haga; M Okamura; K Takao; K Tatemoto, May 2004, JOURNAL OF BIOCHEMISTRY, 135, 5, 605, 613, Scientific journal

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• The receptor-G alpha fusion protein as a tool for ligand screening: A model study using a nociceptin receptor-G alpha(i2) fusion protein, S Takeda; T Okada; M Okamura; T Haga; J Isoyama-Tanaka; H Kuwahara; N Minamino, May 2004, JOURNAL OF BIOCHEMISTRY, 135, 5, 597, 604, Scientific journal

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• Stimulation of increases in intracellular calcium and prostaglandin E-2 generation in chinese hamster ovary cells expressing receptor G alpha(16) fusion proteins, H Suga; S Takeda; T Haga; M Okamura; K Takao; K Tatemoto, May 2004, JOURNAL OF BIOCHEMISTRY, 135, 5, 605, 613, Scientific journal

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• ヒトゲノムの全貌 （ヒトの遺伝子構成、GPCR）, 武田 茂樹, 2004
• Identification of surrogate ligands, for orphan G protein-coupled receptors, S Takeda; A Yamamoto; T Okada; E Matsumura; E Nose; K Kogure; S Kojima; T Haga, Dec. 2003, LIFE SCIENCES, 74, 2-3, 367, 377, Scientific journal

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• Identification of surrogate ligands, for orphan G protein-coupled receptors, S Takeda; A Yamamoto; T Okada; E Matsumura; E Nose; K Kogure; S Kojima; T Haga, Dec. 2003, LIFE SCIENCES, 74, 2-3, 367, 377, Scientific journal

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• 5-oxo-ETE受容体の活性化が引き起こすケモタキシスと細胞内セカンドメッセンジャー濃度変化の測定, 小池太悟; 大日方 英; 和泉 孝志; 武田 茂樹, 2003, 45
• 受容体-G融合タンパク質を用いたリガンド検索, 武田 茂樹, 2003, 37-39
• ヒトゲノムからGタンパク質共役受容体遺伝子を探す, 武田 茂樹, 2003
• G蛋白質共役受容体機能の解析方法, 武田 茂樹, 2003
• Promoter analysis of human cholecystokinin type-A receptor gene, Y Takata; S Takeda; T Kawanami; S Takiguchi; Y Yoshida; K Miyasaka; A Funakoshi, Oct. 2002, JOURNAL OF GASTROENTEROLOGY, 37, 10, 815, 820, Scientific journal
• Identification of G protein-coupled receptor genes from the human genome sequence (vol 520, pg 97, 2002), S Takeda; S Kadowaki; T Haga; H Takaesu; S Mitaku, Jul. 2002, FEBS LETTERS, 523, 1-3, 257, 257
• Identification of G protein-coupled receptor genes from the human genome sequence, S Takeda; S Kadowaki; T Haga; H Takaesu; S Mitaku, Jun. 2002, FEBS LETTERS, 520, 1-3, 97, 101, Scientific journal

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• Identification of a G protein-coupled receptor for 5-oxo-eicosatetraenoic acid, S Takeda; A Yamamoto; T Haga, Apr. 2002, BIOMEDICAL RESEARCH-TOKYO, 23, 2, 101, 108, Scientific journal
• Receptor-G alpha fusion proteins as a tool for ligand screening, ZD Guo; H Suga; M Okamura; S Takeda; T Haga, Apr. 2001, LIFE SCIENCES, 68, 19-20, 2319, 2327, Scientific journal

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• Receptor-G alpha fusion proteins as a tool for ligand screening, ZD Guo; H Suga; M Okamura; S Takeda; T Haga, Apr. 2001, LIFE SCIENCES, 68, 19-20, 2319, 2327, Scientific journal
• 受容体機能の測定法, 武田 茂樹, 2001, 15 - 21
• Systematic search for G protein-coupled receptor genes from human genome database, TAKEDA SHIGEKI, 2001, Jpn. J. Pharmacol., 85 (Suppl. 1), 167
• Nociceptin receptor-Gialpha fusion protein as a model of ligand screening, TAKEDA SHIGEKI, 2001, Neurochemical Research, 26, 298
• Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11, of bacteriophage T4, L Zhao; S Takeda; PG Leiman; F Arisaka, Jun. 2000, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1479, 1-2, 286, 292, Scientific journal

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• Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11, of bacteriophage T4, L Zhao; S Takeda; PG Leiman; F Arisaka, Jun. 2000, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1479, 1-2, 286, 292, Scientific journal
• Selective antagonism by naloxonazine of antinociception by Tyr-D-Arg-Phe-beta-Ala, a novel dermorphin analogue with high affinity at mu-opioid receptors, S Sakurada; S Takeda; T Sato; T Hayashi; M Yuki; M Kutsuwa; K Tan-No; C Sakurada; K Kisara; T Sakurada, Apr. 2000, EUROPEAN JOURNAL OF PHARMACOLOGY, 395, 2, 107, 112, Scientific journal

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• The C-terminal fragment of the precursor tail lysozyme of bacteriophage T4 stays as a structural component of the baseplate after cleavage, S Kanamaru; NC Gassner; NZ Ye; S Takeda; F Arisaka, May 1999, JOURNAL OF BACTERIOLOGY, 181, 9, 2739, 2744, Scientific journal
• The C-terminal fragment of the precursor tail lysozyme of bacteriophage T4 stays as a structural component of the baseplate after cleavage, S Kanamaru; NC Gassner; NZ Ye; S Takeda; F Arisaka, May 1999, JOURNAL OF BACTERIOLOGY, 181, 9, 2739, 2744, Scientific journal
• Comparative Imaging of the Baseplate of Bacteriophage T4 with Atomic Force Microscopy and Electron Microscopy, TAKEDA SHIGEKI, 1999, Res. Comm. in Biochem. Cell & Mol. Biol., 3, 181-191
• Functional assay of allosteric ligands for muscarinic acetylcholine receptors, TAKEDA SHIGEKI, 1999, Jpn. J. Pharmacol., 79 (Suppl. 1), 134
• Discovery of the tail tube gene of bacteriophage Mu and sequence analysis of the sheath and tube genes, S Takeda; T Sasaki; A Ritani; MM Howe; F Arisaka, Jul. 1998, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1399, 1, 88, 92, Scientific journal

  DOI
• Discovery of the tail tube gene of bacteriophage Mu and sequence analysis of the sheath and tube genes, S Takeda; T Sasaki; A Ritani; MM Howe; F Arisaka, Jul. 1998, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1399, 1, 88, 92, Scientific journal
• Mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage T4 by mutational analysis, S Takeda; K Hoshida; F Arisaka, May 1998, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1384, 2, 243, 252, Scientific journal

  DOI
• Mapping of functional sites on the primary structure of the tail lysozyme of bacteriophage T4 by mutational analysis, S Takeda; K Hoshida; F Arisaka, May 1998, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1384, 2, 243, 252, Scientific journal
• Reversible Dissociation and Unforlding of gp57A a Molecular Chaperon, TAKEDA SHIGEKI, 1998, Protein Science, 7 (Suppl. 1), 101
• Reversible Dissociation and Unforlding of gp57A a Molecular Chaperon, TAKEDA SHIGEKI, 1998, Protein Science, 7 (Suppl. 1), 101
• Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone, JH Ha; U Hellman; ER Johnson; LS Li; DB McKay; MC Sousa; S Takeda; C Wernstedt; SM Wilbanks, Oct. 1997, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 27796, 27803, Scientific journal

  DOI
• Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone, JH Ha; U Hellman; ER Johnson; LS Li; DB McKay; MC Sousa; S Takeda; C Wernstedt; SM Wilbanks, Oct. 1997, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 27796, 27803, Scientific journal
• ネガティブ染色, 武田 茂樹, 1997, 881 - 889
• Small angle X-ray scattering experiments of T4 phage gp57A" Photon Factory activity report, TAKEDA SHIGEKI, 1997, Photon Factory activity report, 15 (part B), 73
• Kinetics of peptide binding to the bovine 70 kDa heat shock cognate protein, a molecular chaperone, S Takeda; DB McKay, Apr. 1996, BIOCHEMISTRY, 35, 14, 4636, 4644, Scientific journal

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• Kinetics of peptide binding to the bovine 70 kDa heat shock cognate protein, a molecular chaperone, S Takeda; DB McKay, Apr. 1996, BIOCHEMISTRY, 35, 14, 4636, 4644, Scientific journal
• Control of crystal forms of apoferritin by site-directed mutagenesis, S Takeda; H Yoshimura; S Endo; T Takahashi; K Nagayama, Dec. 1995, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 23, 4, 548, 556, Scientific journal

  DOI
• Control of crystal forms of apoferritin by site-directed mutagenesis, S Takeda; H Yoshimura; S Endo; T Takahashi; K Nagayama, Dec. 1995, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 23, 4, 548, 556, Scientific journal
• SITE-SPECIFIC REACTIVITIES OF CYSTEINE RESIDUES IN HORSE L-APOFERRITIN, S TAKEDA; M YAMAKI; S EBINA; K NAGAYAMA, Feb. 1995, JOURNAL OF BIOCHEMISTRY, 117, 2, 267, 270, Scientific journal

  DOI
• SITE-SPECIFIC REACTIVITIES OF CYSTEINE RESIDUES IN HORSE L-APOFERRITIN, S TAKEDA; M YAMAKI; S EBINA; K NAGAYAMA, Feb. 1995, JOURNAL OF BIOCHEMISTRY, 117, 2, 267, 270, Scientific journal
• Fabrication and control of two-dimensional crystalline arrays of protein molecules, Shigeki Takeda; Shigeru Endo; Hideyuki Yoshimura, 1995, Japanese Journal of Applied Physics, 34, 7S, 3947, 3954, Scientific journal

  DOI
• The receptor-Galpha fusion protein as a tool for ligand screening; a model study using a nociceptin receptor-Gi2alpha fusion protein, TAKEDA SHIGEKI, 1994, J. Biochem. (Tokyo), 135, 597-604
• PREPARATION AND SIGNIFICANCE OF FLUORESCENCE LABELED RECOMBINANT APOFERRITIN FOR INSITU CHARACTERIZATION OF 2D PROTEIN ARRAYS ON MERCURY, S TAKEDA; G PICARD; M YAMAKI; K NAGAYAMA, 1994, ADVANCED MATERIALS '93, II - A & B, 15, A & B, 509, 512, International conference proceedings
• CLONING, EXPRESSION AND CHARACTERIZATION OF HORSE L-FERRITIN IN ESCHERICHIA-COLI, S TAKEDA; M OHTA; S EBINA; K NAGAYAMA, Aug. 1993, BIOCHIMICA ET BIOPHYSICA ACTA, 1174, 2, 218, 220

  DOI
• CLONING, EXPRESSION AND CHARACTERIZATION OF HORSE L-FERRITIN IN ESCHERICHIA-COLI, S TAKEDA; M OHTA; S EBINA; K NAGAYAMA, Aug. 1993, BIOCHIMICA ET BIOPHYSICA ACTA, 1174, 2, 218, 220
• EFFECTS OF SUBSITE ALTERATIONS ON SUBSTRATE-BINDING MODE IN THE ACTIVE-SITE OF HEN EGG-WHITE LYSOZYME, KUMAGAI, I; K MAENAKA; F SUNADA; S TAKEDA; K MIURA, Feb. 1993, EUROPEAN JOURNAL OF BIOCHEMISTRY, 212, 1, 151, 156, Scientific journal

  DOI
• EFFECTS OF SUBSITE ALTERATIONS ON SUBSTRATE-BINDING MODE IN THE ACTIVE-SITE OF HEN EGG-WHITE LYSOZYME, KUMAGAI, I; K MAENAKA; F SUNADA; S TAKEDA; K MIURA, Feb. 1993, EUROPEAN JOURNAL OF BIOCHEMISTRY, 212, 1, 151, 156, Scientific journal
• Bacterial expression and cavity specific fluorescence labeling of horse ferritin L-chain, TAKEDA SHIGEKI, 1993, Protein Engineering, 6, 1013
• A PROTEASE INHIBITOR PRODUCED BY STREPTOMYCES-LIVIDANS 66 EXHIBITS INHIBITORY ACTIVITIES TOWARD BOTH SUBTILISIN BPN' AND TRYPSIN, Y UEDA; S KOJIMA; K TSUMOTO; S TAKEDA; K MIURA; KUMAGAI, I, Aug. 1992, JOURNAL OF BIOCHEMISTRY, 112, 2, 204, 211, Scientific journal

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• A PROTEASE INHIBITOR PRODUCED BY STREPTOMYCES-LIVIDANS 66 EXHIBITS INHIBITORY ACTIVITIES TOWARD BOTH SUBTILISIN BPN' AND TRYPSIN, Y UEDA; S KOJIMA; K TSUMOTO; S TAKEDA; K MIURA; KUMAGAI, I, Aug. 1992, JOURNAL OF BIOCHEMISTRY, 112, 2, 204, 211, Scientific journal
• FUNCTIONAL CONVERSION OF THE HOMOLOGOUS PROTEINS ALPHA-LACTALBUMIN AND LYSOZYME BY EXON EXCHANGE, KUMAGAI, I; S TAKEDA; K MIURA, Jul. 1992, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89, 13, 5887, 5891, Scientific journal

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• FUNCTIONAL CONVERSION OF THE HOMOLOGOUS PROTEINS ALPHA-LACTALBUMIN AND LYSOZYME BY EXON EXCHANGE, KUMAGAI, I; S TAKEDA; K MIURA, Jul. 1992, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 89, 13, 5887, 5891, Scientific journal
• REDESIGN OF THE SUBSTRATE-BINDING SITE OF HEN EGG-WHITE LYSOZYME BASED ON THE MOLECULAR EVOLUTION OF C-TYPE LYSOZYMES, KUMAGAI, I; F SUNADA; S TAKEDA; K MIURA, Mar. 1992, JOURNAL OF BIOLOGICAL CHEMISTRY, 267, 7, 4608, 4612, Scientific journal
• REDESIGN OF THE SUBSTRATE-BINDING SITE OF HEN EGG-WHITE LYSOZYME BASED ON THE MOLECULAR EVOLUTION OF C-TYPE LYSOZYMES, KUMAGAI, I; F SUNADA; S TAKEDA; K MIURA, Mar. 1992, JOURNAL OF BIOLOGICAL CHEMISTRY, 267, 7, 4608, 4612, Scientific journal
• [Recruitment of enzymatic function to alpha-lactalbumin by protein engineering], Kumagai I; Takeda S, Feb. 1992, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
• 酵素機能実現をめざしたa-ラクトアルブミンの蛋白質工学, 武田 茂樹, 1992, 371 - 380
• INTRODUCTION OF ENZYMATIC-ACTIVITY TO ALPHA-LACTALBUMIN BY ARTIFICIAL EXON SHUFFLING, KUMAGAI, I; S TAKEDA; KI MIURA, Dec. 1991, PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 67, 10, 184, 187, Scientific journal
• 食品タンパク質のタンパク質工学, 武田 茂樹, 1991, 137 - 153
• Structural studies of the contractile tail sheath protein of bacteriophage T4 1. Conformational change of the tail sheath upon contraction as probed by differential chemical modification, TAKEDA SHIGEKI, 1991, Biochemistry
• Structural studies of the contractile tail sheath protein of bacteriophage T4 1. Conformational change of the tail sheath upon contraction as probed by differential chemical modification, TAKEDA SHIGEKI, 1991, Biochemistry
• EXPRESSION AND SECRETION OF GOAT ALPHA-LACTALBUMIN AS AN ACTIVE PROTEIN IN SACCHAROMYCES-CEREVISIAE, S TAKEDA; E TAMAKI; K MIURA; KUMAGAI, I, Dec. 1990, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 173, 2, 741, 747, Scientific journal

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• EXPRESSION AND SECRETION OF GOAT ALPHA-LACTALBUMIN AS AN ACTIVE PROTEIN IN SACCHAROMYCES-CEREVISIAE, S TAKEDA; E TAMAKI; K MIURA; KUMAGAI, I, Dec. 1990, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 173, 2, 741, 747, Scientific journal
• [Functional analysis of lysozyme by conversion of amino acid residues], Kumagai I; Sunada F; Takeda S, Oct. 1990, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
• STRUCTURAL STUDIES OF THE CONTRACTILE TAIL SHEATH PROTEIN OF BACTERIOPHAGE-T4 .2. STRUCTURAL-ANALYSES OF THE TAIL SHEATH PROTEIN, GP18, BY LIMITED PROTEOLYSIS, IMMUNOBLOTTING, AND IMMUNOELECTRON MICROSCOPY, F ARISAKA; S TAKEDA; K FUNANE; N NISHIJIMA; S ISHII, May 1990, BIOCHEMISTRY, 29, 21, 5057, 5062, Scientific journal

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• STRUCTURAL STUDIES OF THE CONTRACTILE TAIL SHEATH PROTEIN OF BACTERIOPHAGE-T4 .1. CONFORMATIONAL CHANGE OF THE TAIL SHEATH UPON CONTRACTION AS PROBED BY DIFFERENTIAL CHEMICAL MODIFICATION, S TAKEDA; F ARISAKA; S ISHII; Y KYOGOKU, May 1990, BIOCHEMISTRY, 29, 21, 5050, 5056, Scientific journal

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• STRUCTURAL STUDIES OF THE CONTRACTILE TAIL SHEATH PROTEIN OF BACTERIOPHAGE-T4 .2. STRUCTURAL-ANALYSES OF THE TAIL SHEATH PROTEIN, GP18, BY LIMITED PROTEOLYSIS, IMMUNOBLOTTING, AND IMMUNOELECTRON MICROSCOPY, F ARISAKA; S TAKEDA; K FUNANE; N NISHIJIMA; S ISHII, May 1990, BIOCHEMISTRY, 29, 21, 5057, 5062, Scientific journal
• STRUCTURAL STUDIES OF THE CONTRACTILE TAIL SHEATH PROTEIN OF BACTERIOPHAGE-T4 .1. CONFORMATIONAL CHANGE OF THE TAIL SHEATH UPON CONTRACTION AS PROBED BY DIFFERENTIAL CHEMICAL MODIFICATION, S TAKEDA; F ARISAKA; S ISHII; Y KYOGOKU, May 1990, BIOCHEMISTRY, 29, 21, 5050, 5056, Scientific journal
• EXPRESSION OF GOAT ALPHA-LACTALBUMIN IN ESCHERICHIA-COLI AND ITS REFOLDING TO BIOLOGICALLY-ACTIVE PROTEIN, KUMAGAI, I; S TAKEDA; T HIBINO; K MIURA, Apr. 1990, PROTEIN ENGINEERING, 3, 5, 449, 452, Scientific journal

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• EXPRESSION OF GOAT ALPHA-LACTALBUMIN IN ESCHERICHIA-COLI AND ITS REFOLDING TO BIOLOGICALLY-ACTIVE PROTEIN, KUMAGAI, I; S TAKEDA; T HIBINO; K MIURA, Apr. 1990, PROTEIN ENGINEERING, 3, 5, 449, 452, Scientific journal
• アミノ酸置換によるc型リゾチームの機能変換, 武田 茂樹, 1990, 2632 - 2642
• Site directed mutagenesis studies on oligosaccaride binding sites of hen egg-white lysozyme and a homologues protein alpha-lactalbumin, TAKEDA SHIGEKI, 1990, Protein Engineering, 354
• Structural studies on the contractile tail sheath protein of bacteriophage T4, TAKEDA SHIGEKI, 1990, Protein Engineering, 366
• Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids, Sasaki, Yoshinori;Tsujii, Takashi;Takeda, Shigeki;Obinata, Hideru;Izumi, Takashi;Yamada, Keiichi;Katakai, Ryoichi, 2008, JOURNAL OF PEPTIDE SCIENCE, 14, 12, 1251, 1258

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• Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system, Kajikawa, Mizuho;Sasaki, Kaori;Wakimoto, Yoshitaro;Toyooka, Masaru;Motohashi, Tomoko;Shimojima, Tsukasa;Takeda, Shigeki;Park, Enoch Y.;Maenaka, Katsumi, 2009, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 385, 3, 375, 379

  DOI
• Observation of the Membrane Binding Activity and Domain Structure of gpV, Which Comprises the Tail Spike of Bacteriophage P2, Kageyama, Yasuhiro;Murayama, Masanori;Onodera, Takashi;Yamada, Seiko;Fukada, Harumi;Kudou, Motonori;Tsumoto, Kouhei;Toyama, Yoshiharu;Kado, Syunsaku;Kubota, Kenji;Takeda, Shigeki, 2009, BIOCHEMISTRY, 48, 42, 10129, 10135

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• The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein, Suzuki, Hidetaka;Yamada, Seiko;Toyama, Yoshiharu;Takeda, Shigeki, 2010, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1804, 9, 1738, 1742

  DOI
• The host-binding domain of the P2 phage tail spike reveals a trimeric iron-binding structure, Yamashita, Eiki;Nakagawa, Atsushi;Takahashi, Junichi;Tsunoda, Kin-ichi;Yamada, Seiko;Takeda, Shigeki, 2011, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 67, 837, 841

  DOI
• 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion, Kogure, Ryouta;Toyama, Kazuya;Hiyamuta, Shuichi;Kojima, Itaru;Takeda, Shigeki, 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 416, 1-2, 58, 63

  DOI
• Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion, Harada, Kenichi;Yamashita, Eiki;Nakagawa, Atsushi;Miyafusa, Takamitsu;Tsumoto, Kouhei;Ueno, Takashi;Toyama, Yoshiharu;Takeda, Shigeki, 2013, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1834, 1, 284, 291

  DOI
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells, Ohtsu, Yoshiaki;Nakagawa, Yuko;Nagasawa, Masahiro;Takeda, Shigeki;Arakawa, Hirokazu;Kojima, Itaru, 2014, MOLECULAR AND CELLULAR ENDOCRINOLOGY, 394, 1-2, 70, 79

  DOI
• Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84, Nikaido, Yoshiaki;Koyama, Yuuta;Yoshikawa, Yasushi;Furuya, Toshio;Takeda, Shigeki, 2015, JOURNAL OF BIOCHEMISTRY, 157, 5, 311, 320

  DOI
• In vivo and in vitro evaluation of novel mu-opioid receptor agonist compounds, Nikaido, Yoshiaki;Kurosawa, Aya;Saikawa, Hitomi;Kuroiwa, Satoshi;Suzuki, Chiharu;Kuwabara, Nobuo;Hoshino, Hazime;Obata, Hideaki;Saito, Shigeru;Saito, Tamio;Osada, Hiroyuki;Kobayashi, Isao;Sezutsu, Hideki;Takeda, Shigeki, 2015, EUROPEAN JOURNAL OF PHARMACOLOGY, 767, 193, 200

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain, Yanai, Toshihiro;Kurosawa, Aya;Nikaido, Yoshiaki;Nakajima, Nozomi;Saito, Tamio;Osada, Hiroyuki;Konno, Ayumu;Hirai, Hirokazu;Takeda, Shigeki, 2016, GENES TO CELLS, 21, 7, 717, 727

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• Melanoma antigen family A4 protein produced by transgenic silkworms induces antitumor immune responses, Motokawa, Yoko;Kokubo, Michifumi;Kuwabara, Nobuo;Tatematsu, Ken-Ichiro;Sezutsu, Hideki;Takahashi, Hideyuki;Sakakura, Koichi;Chikamatsu, Kazuaki;Takeda, Shigeki, 2018, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 15, 3, 2512, 2518

  DOI
• Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae, Iwasaki, Takuma;Yamashita, Eiki;Nakagawa, Atsushi;Enomoto, Atsushi;Tomihara, Masashi;Takeda, Shigeki, 2018, GENES TO CELLS, 23, 7, 528, 536

  DOI
• A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription, Ariyani, Winda;Iwasaki, Toshiharu;Miyazaki, Wataru;Yu, Lu;Takeda, Shigeki;Koibuchi, Noriyuki, 2018, TOXICOLOGICAL SCIENCES, 164, 2, 417, 427

  DOI
• Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres, North, Olesia, I;Sakai, Kouhei;Yamashita, Eiki;Nakagawa, Atsushi;Iwazaki, Takuma;Buttner, Carina R.;Takeda, Shigeki;Davidson, Alan R., 2019, NATURE MICROBIOLOGY, 4, 10, 1645, 1653

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• GPR31 and GPR151 are activated under acidic conditions, Mashiko, Misaki;Kurosawa, Aya;Tani, Yuki;Tsuji, Takashi;Takeda, Shigeki, 2019, JOURNAL OF BIOCHEMISTRY, 166, 4, 317, 322

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• Observation of unexpected molecular binding activity for Mu phage tail fibre chaperones, Sakai, Kohei;Iwazaki, Takuma;Yamashita, Eiki;Nakagawa, Atsushi;Sakuraba, Fumiya;Enomoto, Atsushi;Inagaki, Minoru;Takeda, Shigeki, 2019, JOURNAL OF BIOCHEMISTRY, 166, 6, 529, 535

  DOI
• Discovery of small-molecule modulator of heterotrimeric G(i)-protein by integrated phenotypic profiling and chemical proteomics, Kawamura, Tatsuro;Futamura, Yushi;Shang, Erchang;Muroi, Makoto;Janning, Petra;Ueno, Masayoshi;Wilke, Julian;Takeda, Shigeki;Kondoh, Yasumitsu;Ziegler, Slava;Watanabe, Nobumoto;Waldmann, Herbert;Osada, Hiroyuki, 2020, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

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• Secretory expression of thyroid hormone receptor using transgenic silkworms and its DNA binding activity, Nakaya, Hirofumi;Tatematsu, Ken-ichiro;Sezutsu, Hideki;Kuwabara, Nobuo;Koibuchi, Noriyuki;Takeda, Shigeki, 2020, PROTEIN EXPRESSION AND PURIFICATION, 176

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• Stimulation of Increases in Intracellular Calcium and Prostaglandin E_2 Generation in Chinese Hamster Ovary Cells Expressing Receptor-Gα_<16> Fusion Proteins, SUGA Hinako;TAKEDA Shigeki;HAGA Tatsuya;OKAMURA Michiko;TAKAO Kyoichi;TATEMOTO Kazuhiko, May 2004, Journal of Biochemistry, 135, 5, 605, 613
• Expression and Characterization of a Baseplate Protein for Bacteriophage Mu, gp44, KITAZAWA Daisuke;TAKEDA Shigeki;KAGEYAMA Yasuhiro;TOMIHARA Masashi;FUKADA Harumi, May 2005, Journal of Biochemistry, 137, 5, 601, 606
• 5-Oxo-Eicosatetraenoic Acid-Induced Chemotaxis : Identification of a Responsible Receptor hGPCR48 and Negative Regulation by G Protein G_<12/13>, KOIKE Daigo;OBINATA Hideru;YAMAMOTO Atsushi;TAKEDA Shigeki;KOMORI Hironobu;NARA Futoshi;IZUMI Takashi;HAGA Tatsuya, Mar. 2006, Journal of Biochemistry, 139, 3, 543, 549
• Structural Modelling and Mutation Analysis of a Nociceptin Receptor and its Ligand Complexes, AKUZAWA Natsuyo;TAKEDA Shigeki;ISHIGURO Masaji, Jun. 2007, Journal of Biochemistry, 141, 6, 907, 916
• Production and Characterization of the Recombinant Human μ-Opioid Receptor from Transgenic Silkworms, TATENO Mayuko;TOYOOKA Masaru;SHIKANO Yohko;TAKEDA Shigeki;KUWABARA Nobuo;SEZUTSU Hideki;TAMURA Toshiki, Jan. 2009, Journal of Biochemistry, 145, 1, 37, 42
• Receptor : Gα Fusion Protein as a Tool for Ligand Screening, TAKEDA Shigeki, Jan. 2003, Seibutsu Butsuri, 43, 1, 37, 39
• 1P147 2-dimensional crystallization of mutant bacterioferritin(4. Protein engineering,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006), Takasaki Yuka;Noguchi Motoi;Takeda Shigeki, 2006, Seibutsu Butsuri, 46, 2
• The Receptor-Gα Fusion Protein as a Tool for Ligand Screening: a Model Study Using a Nociceptin Receptor-Gα_i2 Fusion Protein, Takeda Shigeki;Okada Tomoaki;Okamura Michiko;Haga Tatsuya;Isoyama-Tanaka Junko;Kuwahara Hiromiki;Minamino Naoto, 2004, The Journal of Biochemistry, 135, 5, 597, 604
• Stimulation of Increases in Intracellular Calcium and Prostaglandin E₂ Generation in Chinese Hamster Ovary Cells Expressing Receptor-Gα₁₆ Fusion Proteins, Suga Hinako;Takeda Shigeki;Haga Tatsuya;Okamura Michiko;Takao Kyoichi;Tatemoto Kazuhiko, 2004, The Journal of Biochemistry, 135, 5, 605, 613
• Application of Transgenic Silkworms for Recombinant Protein Expression, TAKEDA SHIGEKI, 2016, Sen'i Gakkaishi, 72, 10, P, 465-P-466
• Ligand screening of THTR G protein-coupled receptors using receptor-Galpha16 fusion proteins, Takao Kyoichi;Takao Tetsuya;Kazama Hiromi;Yoshida Yuka;Sakai Mamiko;Takeda Shigeki;Haga Tatsuya;Kokubun Shinichiro;Suga Hinako, 2004, Proceedings of Annual Meeting of the Physiological Society of Japan, 2004, 0, S129, S129
• Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis., Takeda Shigeki;Suzuki Makoto;Yamada Takahito;Kageyama Manabu;Arisaka Fumio, Biochimica et biophysica acta, 1699, 1-2

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• Expression and characterization of a baseplate protein for bacteriophage Mu, gp44., Kitazawa Daisuke;Takeda Shigeki;Kageyama Yasuhiro;Tomihara Masashi;Fukada Harumi, Journal of biochemistry, 137, 5

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• 5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13)., Koike Daigo;Obinata Hideru;Yamamoto Atsushi;Takeda Shigeki;Komori Hironobu;Nara Futoshi;Izumi Takashi;Haga Tatsuya, Journal of biochemistry, 139, 3

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• Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes., Akuzawa Natsuyo;Takeda Shigeki;Ishiguro Masaji, 24 Apr. 2007, Journal of biochemistry, 141, 6

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• Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids., Sasaki Yoshinori;Tsujii Takashi;Takeda Shigeki;Obinata Hideru;Izumi Takashi;Yamada Keiichi;Katakai Ryoichi, Journal of peptide science : an official publication of the European Peptide Society, 14, 12

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• Production and characterization of the recombinant human mu-opioid receptor from transgenic silkworms., Tateno Mayuko;Toyooka Masaru;Shikano Yohko;Takeda Shigeki;Kuwabara Nobuo;Sezutsu Hideki;Tamura Toshiki, 04 Nov. 2008, Journal of biochemistry, 145, 1

  DOI
• The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity., Toyooka Masaru;Tujii Takashi;Takeda Shigeki, Journal of neuroscience research, 87, 6

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• Observation of the membrane binding activity and domain structure of gpV, which comprises the tail spike of bacteriophage P2., Kageyama Yasuhiro;Murayama Masanori;Onodera Takashi;Yamada Seiko;Fukada Harumi;Kudou Motonori;Tsumoto Kouhei;Toyama Yoshiharu;Kado Syunsaku;Kubota Kenji;Takeda Shigeki, Biochemistry, 48, 42

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• トランスジェニックカイコによるがん抗原タンパクの作成とがんワクチン療法への応用, ;;;;, Apr. 2016, 119, 4, 574
• ファージ・ルネッサンス　ファージ発見から100年たった今　ファージ感染機構の構造生物学からの解析(Phage renaissance: 100 years have passed since phage discovery　Structural studies of bacteriophage host recognition and infection process), 武田 茂樹, Feb. 2016, 71, 1, 54
• トランスジェニックカイコを用いたがん抗原タンパクによるがんワクチン療法の開発, ;;;;, Jun. 2016, 34, 2, 110
• 新たに見出したプロトン感受性Gタンパク質共役受容体とそのアンタゴニストの同定, ;;;;;, Dec. 2017, 2017年度, [1P
• DNA修復阻害剤を用いた食品由来抗酸化剤による抗腫瘍機構の解析, ;;;, Dec. 2017, 2017年度, [1P
• トランスジェニックカイコで発現させたがん抗原の発現および精製, ;;;;;, Dec. 2017, 2017年度, [1P
• GPCRの熱安定性および長期安定性の新規スルホベタイン類による向上, ;;;;;, Dec. 2017, 2017年度, [2P
• 甲状腺ホルモン受容体を介する転写におけるイソフラボン類の作用, ;;;;, Dec. 2018, 94, 4, 1226
• 5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion., Kogure Ryouta;Toyama Kazuya;Hiyamuta Shuichi;Kojima Itaru;Takeda Shigeki, 06 Nov. 2011, Biochemical and biophysical research communications, 416, 1-2

  DOI
• Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells., Ohtsu Yoshiaki;Nakagawa Yuko;Nagasawa Masahiro;Takeda Shigeki;Arakawa Hirokazu;Kojima Itaru, 10 Jul. 2014, Molecular and cellular endocrinology, 394, 1-2

  DOI
• Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84., Nikaido Yoshiaki;Koyama Yuuta;Yoshikawa Yasushi;Furuya Toshio;Takeda Shigeki, 25 Nov. 2014, Journal of biochemistry, 157, 5

  DOI
• In vivo and in vitro evaluation of novel μ-opioid receptor agonist compounds., Nikaido Yoshiaki;Kurosawa Aya;Saikawa Hitomi;Kuroiwa Satoshi;Suzuki Chiharu;Kuwabara Nobuo;Hoshino Hazime;Obata Hideaki;Saito Shigeru;Saito Tamio;Osada Hiroyuki;Kobayashi Isao;Sezutsu Hideki;Takeda Shigeki, 20 Oct. 2015, European journal of pharmacology, 767

  DOI
• Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain., Yanai Toshihiro;Kurosawa Aya;Nikaido Yoshiaki;Nakajima Nozomi;Saito Tamio;Osada Hiroyuki;Konno Ayumu;Hirai Hirokazu;Takeda Shigeki, 17 May 2016, Genes to cells : devoted to molecular & cellular mechanisms, 21, 7

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test., Enomoto Rina;Kurosawa Aya;Nikaido Yoshiaki;Mashiko Misaki;Saheki Toshihiko;Nakajima Nozomi;Kuroiwa Satoshi;Otobe Michinari;Ohsaki Maki;Tooyama Kazuya;Inoue Yusuke;Kuwabara Nobuo;Kikuchi Osamu;Kitamura Tadahiro;Kojima Itaru;Nakagawa Yuko;Saito Tamio;Osada Hiroyuki;Futahashi Mizuko;Sezutsu Hideki;Takeda Shigeki, 17 Aug. 2017, European journal of pharmacology, 814

  DOI
• Most of it started with T4 phage and was then taken over., Takeda Shigeki, 06 Oct. 2017, Biophysical reviews, 10, 2

  DOI
• Melanoma antigen family A4 protein produced by transgenic silkworms induces antitumor immune responses., Motokawa Yoko;Kokubo Michifumi;Kuwabara Nobuo;Tatematsu Ken-Ichiro;Sezutsu Hideki;Takahashi Hideyuki;Sakakura Koichi;Chikamatsu Kazuaki;Takeda Shigeki, 04 Jan. 2018, Experimental and therapeutic medicine, 15, 3

  DOI
• A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription., Ariyani Winda;Iwasaki Toshiharu;Miyazaki Wataru;Yu Lu;Takeda Shigeki;Koibuchi Noriyuki, Toxicological sciences : an official journal of the Society of Toxicology, 164, 2

  DOI
• Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae., Iwasaki Takuma;Yamashita Eiki;Nakagawa Atsushi;Enomoto Atsushi;Tomihara Masashi;Takeda Shigeki, 16 May 2018, Genes to cells : devoted to molecular & cellular mechanisms, 23, 7

  DOI
• GPR31 and GPR151 are activated under acidic conditions., Mashiko Misaki;Kurosawa Aya;Tani Yuki;Tsuji Takashi;Takeda Shigeki, 23 May 2019, Journal of biochemistry

  DOI
• Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres., North Olesia I;Sakai Kouhei;Yamashita Eiki;Nakagawa Atsushi;Iwazaki Takuma;Büttner Carina R;Takeda Shigeki;Davidson Alan R, 17 Jun. 2019, Nature microbiology, 4, 10

  DOI
• Observation of unexpected molecular binding activity for Mu phage tail fibre chaperones., Sakai Kohei;Iwazaki Takuma;Yamashita Eiki;Nakagawa Atsushi;Sakuraba Fumiya;Enomoto Atsushi;Inagaki Minoru;Takeda Shigeki, Journal of biochemistry, 166, 6

  DOI
• Secretory expression of thyroid hormone receptor using transgenic silkworms and its DNA binding activity., Nakaya Hirofumi;Tatematsu Ken-Ichiro;Sezutsu Hideki;Kuwabara Nobuo;Koibuchi Noriyuki;Takeda Shigeki, 05 Aug. 2020, Protein expression and purification, 176

  DOI
• Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics., Kawamura Tatsuro;Futamura Yushi;Shang Erchang;Muroi Makoto;Janning Petra;Ueno Masayoshi;Wilke Julian;Takeda Shigeki;Kondoh Yasumitsu;Ziegler Slava;Watanabe Nobumoto;Waldmann Herbert;Osada Hiroyuki, 31 Aug. 2020, Bioscience, biotechnology, and biochemistry

  DOI
• The N-Terminal Domain of GPR61, an Orphan G-Protein-Coupled Receptor, Is Essential for Its Constitutive Activity, Toyooka, Masaru;Tujii, Takashi;Takeda, Shigeki, 2009, JOURNAL OF NEUROSCIENCE RESEARCH, 87, 6, 1329, 1333

  DOI
• MRGD, a MAS-related G-protein Coupled Receptor, Promotes Tumorigenisis and Is Highly Expressed in Lung Cancer, Nishimura, Satoko;Uno, Makiko;Kaneta, Yasuyuki;Fukuchi, Keisuke;Nishigohri, Haruyuki;Hasegawa, Jun;Komori, Hironobu;Takeda, Shigeki;Enomoto, Katsuhiko;Nara, Futoshi;Agatsuma, Toshinori, 2012, PLOS ONE, 7, 6

  DOI
• Identification of Physiologically Active Substances as Novel Ligands for MRGPRD, Uno, Makiko;Nishimura, Satoko;Fukuchi, Keisuke;Kaneta, Yasuyuki;Oda, Yoko;Komori, Hironobu;Takeda, Shigeki;Haga, Tatsuya;Agatsuma, Toshinori;Nara, Futoshi, 2012, JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Enomoto, Rina;Kurosawa, Aya;Nikaido, Yoshiaki;Mashiko, Misaki;Saheki, Toshihiko;Nakajima, Nozomi;Kuroiwa, Satoshi;Otobe, Michinari;Ohsaki, Maki;Tooyama, Kazuya;Inoue, Yusuke;Kuwabara, Nobuo;Kikuchi, Osamu;Kitamura, Tadahiro;Kojima, Itaru;Nakagawa, Yuko;Saito, Tamio;Osada, Hiroyuki;Futahashi, Mizuko;Sezutsu, Hideki;Takeda, Shigeki, 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• Staphylococcal Phage in Combination with Staphylococcus epidermidis as a Potential Treatment for Staphylococcus aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants, Shimamori, Yuzuki;Mitsunaka, Shoichi;Yamashita, Hirotaka;Suzuki, Tohru;Kitao, Tomoe;Kubori, Tomoko;Nagai, Hiroki;Takeda, Shigeki;Ando, Hiroki, 2021, VIRUSES-BASEL, 13, 1

  DOI
• Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis, Shimamori, Yuzuki;Pramono, Ajeng K.;Kitao, Tomoe;Suzuki, Tohru;Aizawa, Shin-ichi;Kubori, Tomoko;Nagai, Hiroki;Takeda, Shigeki;Ando, Hiroki, 2021, CURRENT MICROBIOLOGY, 78, 4, 1267, 1276

  DOI
• Impact of sulforaphane on genome integrity, Kurosawa, Aya;Nishiba, Seiya;Toriumi, Kazuya;Takeda, Shigeki;Adachi, Noritaka, 2021, FREE RADICAL BIOLOGY AND MEDICINE, 165

  DOI
• In vitro assessment of antitumor immune responses using tumor antigen proteins produced by transgenic silkworms, Yamada, Kanae;Masuda, Kei;Ida, Shota;Tada, Hiroe;Bando, Minori;Abe, Kanako;Tatematsu, Ken-ichiro;Sezutsu, Hideki;Oyama, Tetsunari;Chikamatsu, Kazuaki;Takeda, Shigeki, 2021, JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 32, 6

  DOI
• Dynamic alterations of circulating T lymphocytes and the clinical response in patients with head and neck squamous cell carcinoma treated with nivolumab, Tada, Hiroe;Takahashi, Hideyuki;Yamada, Kanae;Masuda, Kei;Nagata, Yurino;Uchida, Miho;Shino, Masato;Ida, Shota;Mito, Ikko;Matsuyama, Toshiyuki;Oyama, Tetsunari;Tatematsu, Ken-Ichiro;Sezutsu, Hideki;Takeda, Shigeki;Chikamatsu, Kazuaki, 2022, CANCER IMMUNOLOGY IMMUNOTHERAPY, 71, 4, 851, 863

  DOI
• Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain, Sakai, Aya;Yasui, Takeshi;Watanave, Masashi;Tatsumi, Rine;Yamamoto, Yoshihiko;Takano, Wataru;Tani, Yuki;Okamura, Izumi;Hirai, Hirokazu;Takeda, Shigeki, 2022, GENES TO CELLS, 27, 5, 345, 355

  DOI
• あなたの知らないファージの世界　三次元構造解析により明らかになったMuファージサブユニットの特徴, 武田 茂樹, Feb. 2021, 76, 1, 42
• 高LET線ならびに放射線類似薬により誘発されるDNA二本鎖切断の修復における修復経路の重要度の解析(Requirement of DNA double-strand break repair pathways for repairing high LET radiation- and radiomimetic agents-induced DNA damage), ;;;;, Oct. 2020, 63回, 75
• Staphylococcal Phage in Combination with Staphylococcus Epidermidis as a Potential Treatment for Staphylococcus Aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants., Shimamori Yuzuki;Mitsunaka Shoichi;Yamashita Hirotaka;Suzuki Tohru;Kitao Tomoe;Kubori Tomoko;Nagai Hiroki;Takeda Shigeki;Ando Hiroki, 22 Dec. 2020, Viruses, 13, 1

  DOI
• Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis., Shimamori Yuzuki;Pramono Ajeng K;Kitao Tomoe;Suzuki Tohru;Aizawa Shin-Ichi;Kubori Tomoko;Nagai Hiroki;Takeda Shigeki;Ando Hiroki, 26 Feb. 2021, Current microbiology, 78, 4

  DOI
• In vitro assessment of antitumor immune responses using tumor antigen proteins produced by transgenic silkworms., Yamada Kanae;Masuda Kei;Ida Shota;Tada Hiroe;Bando Minori;Abe Kanako;Tatematsu Ken-Ichiro;Sezutsu Hideki;Oyama Tetsunari;Chikamatsu Kazuaki;Takeda Shigeki, 17 May 2021, Journal of materials science. Materials in medicine, 32, 6

  DOI
• Dynamic alterations of circulating T lymphocytes and the clinical response in patients with head and neck squamous cell carcinoma treated with nivolumab., Tada Hiroe;Takahashi Hideyuki;Yamada Kanae;Masuda Kei;Nagata Yurino;Uchida Miho;Shino Masato;Ida Shota;Mito Ikko;Matsuyama Toshiyuki;Oyama Tetsunari;Tatematsu Ken-Ichiro;Sezutsu Hideki;Takeda Shigeki;Chikamatsu Kazuaki, 31 Aug. 2021, Cancer immunology, immunotherapy : CII, 71, 4

  DOI
• Development of novel potent ligands for GPR85, an orphan G protein-coupled receptor expressed in the brain., Sakai Aya;Yasui Takeshi;Watanave Masashi;Tatsumi Rine;Yamamoto Yoshihiko;Takano Wataru;Tani Yuki;Okamura Izumi;Hirai Hirokazu;Takeda Shigeki, 01 Mar. 2022, Genes to cells : devoted to molecular & cellular mechanisms, 27, 5

  DOI

MISC

• トランスジェニックカイコを用いて製造されるバイオ医薬品の品質管理戦略構築に関する考え方, 石井明子; 多田稔; 立松謙一郎; 冨田正浩; 市原隆光; 山口秀人; 田中貴; 田中剛; 原園景; 木吉真人; 柴田寛子; 遊佐敬介; 佐藤陽治; 武田茂樹; 伊藤孝司; 川崎ナナ; 瀬筒秀樹, 10 Oct. 2019, 医薬品医療機器レギュラトリーサイエンス, 50, 10, 615‐627
• トランスジェニックカイコで発現させたがん抗原の発現および精製, 坂東 みのり; 近松 一朗; 桑原 伸夫; 瀬筒 秀樹; 立松 謙一郎; 武田 茂樹, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [1P, 1389]
• トランスジェニックカイコで発現させたがん抗原の発現および精製, 坂東みのり; 近松一朗; 桑原伸夫; 瀬筒秀樹; 立松謙一郎; 武田茂樹, Dec. 2017, 日本生化学会大会(Web), 90th, ROMBUNNO.1P‐1389 (WEB ONLY), 1389]
• トランスジェニックカイコで発現させたがんワクチンの精製と活性測定, 元川瑶子; 近松一朗; 桑原伸夫; 瀬筒秀樹; 立松謙一郎; 武田茂樹, 2016, 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.1P‐0824 (WEB ONLY)
• 胆汁酸受容体TGR5に対する新規リガンドの解析, 榎本理奈; 二階堂良亮; 黒沢綾; 黒岩聡; 井上裕介; 乙部理也; 斎藤臣雄; 桑原伸夫; 瀬筒秀樹; 二橋美瑞子; 武田茂樹, 2016, 日本分子生物学会年会プログラム・要旨集(Web), 39th, ROMBUNNO.3P‐0408 (WEB ONLY)
• オピオイド受容体新規アゴニストの同定と評価, 二階堂良亮; 黒沢綾; 齋川瞳; 桑原伸夫; 星野一; 小幡英章; 齋藤繁; 齋藤臣雄; 小林功; 瀬筒秀樹; 武田茂樹, 2015, GPCR研究会プログラム・抄録集, 12th, 50
• トランスジェニックカイコで発現させた組換えタンパク質の解析, 黒岩聡志; 小久保倫文; 元川揺子; 桑原伸夫; 二橋(長内; 美瑞子; 鈴木誉保; 立松謙一郎; 瀬筒秀樹; 武田茂樹, 2014, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 3P-0071 (WEB ONLY)
• オピオイド受容体に対する新規アゴニスト化合物の評価, 齋川瞳; 二階堂良亮; 黒沢綾; 桑原伸夫; 星野一; 小幡英章; 齋藤繁; 齋藤臣雄; 小林功; 瀬筒秀樹; 武田茂樹, 2014, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 3P-0098 (WEB ONLY)
• バクテリオファージMuのネックサブユニットgp36の結晶構造, 岩崎拓真; 山下栄樹; 中川敦史; 武田茂樹, 2014, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 2P-0074 (WEB ONLY)
• バクテリオファージMu尾繊維サブユニットとその特異的シャペロン複合体の精製,構造解析, 坂井康平; 山下栄樹; 中川敦史; 武田茂樹, 2014, 日本分子生物学会年会プログラム・要旨集(Web), 37th, 2P-0075 (WEB ONLY)
• 摂食抑制ペプチドNesfatin-1の細胞内シグナル伝達機構の解析とその特異的受容体の探索, 橋本 貢士; 石田 恵美; 武田 茂樹; 登丸 琢也; 石井 角保; 小澤 厚志; 渋沢 信行; 佐藤 哲郎; 岡田 秀一; 清水 弘行; 山田 正信; 森 昌朋, Apr. 2013, 日本内分泌学会雑誌, 89, 1, 274, 274
• インスリン分泌促進物質の精製と解析, 中嶋希; 黒岩聡志; 小久保倫文; 武田茂樹; 立松謙一郎; 瀬筒秀樹; 三浦敦子; 森昌朋, 2013, 日本分子生物学会年会プログラム・要旨集(Web), 36th, 1P-0516 (WEB ONLY)
• 遺伝子組換えカイコを用いたオピオイドμ受容体‐Giα融合タンパク質の発現と活性評価, 二階堂良亮; 武田茂樹; 桑原伸夫; 瀬筒秀樹; 小林功; 田村俊樹, 2011, 日本分子生物学会年会プログラム・要旨集(Web), 34th, 1T14PI-6 (WEB ONLY)
• Muファージのテールスパイクタンパク質gp45のC末端のX線構造解析, 原田健一; 山下栄樹; 中川敦史; 上野貴志; 武田茂樹, 2011, 日本結晶学会年会講演要旨集, 2011, 103
• BmNPVバクミドを用いたヒト膜タンパク質受容体のカイコ個体での生産, KAJIKAWA MIZUHO; SASAKI KAORI; KUROKI KIMIKO; HASHIGUCHI TAKAO; OKABE YUKI; FUKUHARA HIDEO; TAKEDA MAKOTO; YANAGI YUSUKE; WAKIMOTO YOSHITARO; TOYOOKA MASARU; TAKEDA SHIGEKI; MOTOHASHI TOMOKO; SHIMOJIMA TSUKASA; PARK ENOCH Y; MAENAKA KATSUMI, 25 Aug. 2009, 日本生物工学会大会講演要旨集, 61st, 281
• BmNPVバクミドとカイコ個体を用いたヒトGタンパク質共役型受容体の生産, KAJIKAWA MIZUHO; SASAKI KAORI; WAKIMOTO YOSHITARO; TOYOOKA MASARU; TAKEDA SHIGEKI; MOTOHASHI TOMOKO; SHIMOJIMA TSUKASA; PARK ENOCH Y; MAENAKA KATSUMI, 23 May 2008, 日本蛋白質科学会年会プログラム・要旨集, 8th, 124

Books etc

• 物理生化学, Joint work, 2003
• G protein-coupled receptors: Structure, function, and ligand screening, Single work, T. Haga; S. Takeda, CRC Press, Florida, Oct. 2006
• Observation of unexpected molecular binding activity for Mu phage tail fiber chaperones., Single work, Sakai K; Iwazaki T; Yamashita E; Nakagawa A; Sakuraba F; Enomoto A; Inagaki M; Takeda S, Journal of biochemistry, Aug. 2019
• Three-dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae., Single work, Iwasaki T; Yamashita E; Nakagawa A; Enomoto A; Tomihara M; Takeda S, May 2019

Presentations

• Features of Mu phage subunits revealed by three-dimensional structural analysis, Takeda Shigeki, Japanese Society for Bacteriology, 23 Mar. 2021
• Application to cancer immunotherapy with tumor antigens expressed using transgenic silkworms, Kanae Yamada, Ken-ichiro Tatematsu, Hideki Sezutsu,Kazuaki Chikamatsu, Shigeki Takeda, 第４３回日本分子生物学会, 05 Dec. 2020
• Expression of human m opioid receptors using transgenic silkworm, 武田茂樹, 34th annual meeting of society for neuroscience, 2004, San Diego
• 5-oxo-ETEに対するヒト顆粒球のケモタキシスはhGPCR48を介して起こる, 武田茂樹, 第27回分子生物学会年会, 2004
• トランスジェニック蚕によるヒトオピオイドμ受容体の発現, 武田茂樹, 第27回分子生物学会年会, 2004
• Expression and purification of Bacteriophage Mu subunits, 武田茂樹, 蛋白質科学会, 2004, 横浜
• バクテリオファージMuの基盤サブユニットgp44の解析, 武田茂樹, 日本生化学会, 2005
• バクテリオファージMuの基盤蛋白質gp44のX線結晶構造解析, 武田茂樹, 結晶学会, 2005
• ヒトGタンパク質共役受容体MrgX2のリガンド探索, 武田茂樹; 大日方英; 和泉孝志, 第28回日本分子生物学会大会, 2005
• ヒトノシセプチン受容体の変異体作製とコンピュータモデリングによる解析, 武田茂樹, 日本薬学会第126年会, 2005
• hGPCR48を介した5-oxo-ETEに対するケモタキシスの解析, 武田茂樹, 脂質研究会年度, 2003
• Functional analysis of bitter taste receptors, TAKEDA SHIGEKI, 20th IUBMB international congress of Biochemistry and Molecular Biology and 11th FASOBMB congress, Jun. 2006, Kyoto
• Partial purification of natural ligands for orphan G-protein coupled receptors, TAKEDA SHIGEKI, 20th IUBMB international congress of Biochemistry and Molecular Biology and 11th FASOBMB congress, Jun. 2006, Kyoto
• Purification and characterization of protein subunit for TMA phage, TAKEDA SHIGEKI, 20th IUBMB international congress of Biochemistry and Molecular Biology and 11th FASOBMB congress, Jun. 2006, Kyoto
• ランダムペプチドライブラリーからのＧタンパク質共役受容体リガンドの検索, 武田 茂樹; 山田 圭一; 片貝 良一, 第４３回日本生物物理年会, Dec. 2005
• 5-oxo-ETE受容体に対するペプチドリガンドの検索, 武田 茂樹; 山田 圭一; 片貝 良一, 第２８回日本分子生物学会年会, Dec. 2005
• Ｐ２ファージ基盤サブユニットの精製, 武田 茂樹, 第２８回日本分子生物学会年会, Dec. 2005
• バクテリオファージMu頭部サブユニットの調製, 冨原 雅史; 武田 茂樹; 窪田 健二; 高橋 亮, 日本分子生物学会, Dec. 2005
• Muファージサブユニットの構造解析, 武田 茂樹, 大阪大学蛋白質研究所 公開セミナー, Sep. 2006
• バクテリオファージMugp45の精製と解析, 武田 茂樹, 特定領域研究「生体超分子構造」第2回ワークショップ, Aug. 2006
• Ｇタンパク質共役受容体のリガンド検索, 武田 茂樹, 特定領域研究 「生体機能分子の創製」 第二回公開シンポジウム, Dec. 2006
• Gタンパク質共役受容体のリガンド開発ースクリーニングから設計へー, 武田茂樹, 群馬大学工学研究科・生体調節研究所 第５回生命科学セミナー, 06 Jul. 2007
• 新規喘息・アレルギー治療薬の開発, 武田茂樹, JSTイノベーションサテライト新潟研究成果発表会, 05 Jul. 2007
• Ｍｕファージ サブユニット複合体精製の試み, 武田茂樹, 特定領域研究「生体超分子構造」第三回研究会, 11 Aug. 2007
• Muファージサブユニットの構造解析, 武田茂樹, 14 Sep. 2006
• 遺伝子共発現によるＭｕファージ サブユニット複合体精製の試み, 武田茂樹, 特定領域研究「生態超分子構造」ワークショップ, 22 Jul. 2007
• Ｇタンパク質共役受容体ＧＰＲ６１のＮ末端による恒常的活性化の検証, 豊岡勝; 武田茂樹, 日本分子生物学会, Dec. 2007
• バクテリオファージＭｕ基盤サブユニットｇｐ４５の精製と解析, 鈴木栄貴; 武田茂樹, 日本分子生物学会, Dec. 2007
• BmNPV expression systam, Application to human immuune receptors and membrane proteins, M.Kajikawa; S.Takeda; K.Maenaka, Dec. 2007
• バクテリオファージ基盤サブユニットの精製と解析, 武田 茂樹; 鈴木 栄貴; 木全 英喜; 小野寺 崇; 村山 正承; 影山 泰大, 日本生化学会 関東支部例会, 27 Jun. 2008
• 苦味受容体の機能解析, 新井 萌子; 田中 麻衣; 伊良波 あすみ; 武田 茂樹, 日本生化学会 関東支部例会, 27 Jun. 2008
• 糸状菌培養液からの機能不明G蛋白質共役受容体(GPCR)の新規リガンド検索, 遠山 和矢; 豊岡 勝; 武田 茂樹, 日本生化学会 関東支部例会, 27 Jun. 2008
• 微生物培養液からのＧタンパク質共役受容体ＧＰＲ１４８のリガンド検索, 遠山和矢; 武田茂樹, 日本生化学会, 18 Dec. 2008
• 微生物培養液からのＧタンパク質共役受容体ＧＰＲ１４８のリガンド検索, 遠山和矢; 武田茂樹, 群馬大学ファイブロバイオプロセス研究会, 12 Dec. 2008
• 機能物質の探査・利用開発のための生物資源ライブラリー作製の重要性とその活性スクリーニング方法の紹介, 武田茂樹, 群馬大学ファイブロバイオプロセス研究会, 18 Dec. 2008
• Ｍｕファージ基盤サブユニットの精製と解析, 武田茂樹, 「生体超分子構造」公開シンポジウム, 19 Dec. 2008
• 光る糸を吐くカイコの誕生とカイコの薬品開発への応用, 武田茂樹, 群馬大学ファイブロバイオプロセス研究会, 29 Oct. 2009
• GPR84の機能解析を目指したアゴニスト探索, 小山雄大; 武田茂樹; 岡部隆義, 第83回日本生化学会大会, 10 Dec. 2010
• カイコ発現系を用いたオピオイドμ受容体T4L融合タンパク質(MOR-T4L)の発現と可溶化, 大崎真希; 武田茂樹; 若松馨, 第83回日本生化学会大会, 10 Dec. 2010
• バクテリオファージMu基盤タンパク質gp46のX線結晶解析に向けた精製, 金澤悠子; 武田茂樹; 津本浩平, 第83回日本生化学会大会, 10 Dec. 2010
• P2ファージテイルタンパク質ｇｐVの解析, 武田茂樹, 大阪大学蛋白質研究所セミナー, 10 Sep. 2010
• G protein-coupled receptors and insulin secretion; drug screening for type 2 diabetes, Shgeki Takeda, 14th International Congress of Endocrinology, 30 Mar. 2010, Kyoto
• Mutational analysis and molecular modeling of a G protein-coupled receptor GPR84, Yoshiaki Nikaido; Yasushi Yoshikawa; Toshio Furuya; Shigeki Takeda, 12 May 2012
• インスリン分泌を促進する化合物の探索とそれに関与する受容体の同定, 木暮亮太; 遠山和也; 小島至; 武田茂樹, 09 Dec. 2011
• バクテリオファージMu基盤サブユニットgp45変異体の精製と解析, 上野貴志; 外山吉治; 武田茂樹, 09 Dec. 2011
• バクテリオファージMu基盤サブユニットの発現と精製, 塚本奈央; 武田茂樹, ファージ研究会, 19 Sep. 2012
• メタゲノム解析による淡水中のファージDNAの検出, 島守祐月; 志村洋一郎; 稲元民夫; 加藤毅; 武田茂樹; 福島淳, ファージ研究会, 19 Sep. 2012
• Gタンパク質共役受容体GPR84の変異体と分子モデルによる解析, 二階堂良亮; 吉川寧; 古谷俊夫; 小山雄大; 武田茂樹, 分子生物学会, 10 Dec. 2012
• Purification of bacteriophage Mu baseplate protein, gp46, for structual analysis, 金澤悠子; 武田茂樹, 09 Dec. 2010
• バクテリオファージMu基盤サブユニットgp45変異体の精製と解析, 上野 貴志; 外山 吉治; 武田茂樹, 分子生物学会, 16 Dec. 2011
• インスリン分泌を促進する化合物の探索と、それに関与する受容体の同定, 木暮 亮太; 遠山 和矢; 小島 至; 武田 茂樹, 分子生物学会, 16 Dec. 2011
• GPR61の恒常的活性化に関与するN末端アミノ酸配列の同定, 中島 隆博; 武田 茂樹, 分子生物学会, 10 Dec. 2012
• バクテリオファージＭｕ基盤サブユニットの発現と精製, 塚本奈央; 武田茂樹, 分子生物学会, 10 Dec. 2012
• Purification and characterization of substances that enhance insulin secretion., Nozomi Nakajima; Satoshi Kuroiwa; Michifumi Kokubo; Shigeki Takeda; Kenichiro Tatematsu; Hideki Sezutsu; Atsuko Miura; Masatomo Mori, The Molecular Biology Society of Japan, 06 Dec. 2013
• Identification of an intermediate complex for Mu phage baseplate assembly, Nao Tsukamoto; Shigeki Takeda, The Molecular Biology Society of Japan, 06 Dec. 2013
• Characterization of Mu phage tube protein gp40 and its polymerization, Yuzuki Shimamori; Nao Tsukamoto; Shigeki Takeda, The Molecular Biology Society of Japan, 06 Dec. 2013

Industrial Property Rights

• Patent right, 特願2021-139639
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Awards

• Early-Career recognition award, K. Yamada, Journal of Materials Science: Materials in Medicine, 10 Mar. 2022, Official journal
• 01 Feb. 2008

Research Projects

• Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, 01 Apr. 2018, 31 Mar. 2022, 18H03379
• Biochemical preparation of isotpe-labelled lipopolysaccharide and nmr analysis of host recognition mechanism of phage, Inagaki Minoru; KARITA Shuichi; TAKEDA Shigeki; FUJITA Katsutoshi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Mie University, 01 Apr. 2014, 31 Mar. 2017, For incorpolation of 13C isotope-labelled galactose into the non-reducing end of lipopolysaccharide core structure, galE gene on E. coli C bacterium was determined on the gene. The mutant of E. coli F2513 were prepared by deletion of Galactosyl transferase genes, waaW and waaT. However, those mutants doesn't propagete in the cultural medium, and not yet certified the altered saccharide stracture on R-core lipopolysaccharide. By using the ASKA(-) clone, JW3598AM, the protein fraction of WaaU (hetosyl transferase) was prepared and submitted to treat the Salmonella bacterium. The incorpolation of an unnatural Hep residue was confirmed on the lipopolysacchride of Salmonella, using DOC-PAGE and LC-ESI-MS., 26660085

  対象リソースIRI
• Structural study of bacteriophage Mu, TAKEDA Shigeki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2012, 31 Mar. 2015, We purified Mu phage tailfiber (gp49-gp50 complex) and neck subunit (gp36). We also crystallize them and determined their three dimensional structure. Tailfiber consisted of trimer of beta-strand and beta-helix. Neck gp36 was monomer and did not formed ring sturcture, 24570123

  対象リソースIRI
• Identification of peptide ligands for lipid receptors, TAKEDA Shigeki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Gunma University, 2009, 2011, A random hexapeptide library was screened to identify novel peptide ligands for a TGR5, which is a G-protein-coupled receptor for bioactive steroids. We successfully identified a weak agonist peptide (Ac-WLFLHV-NH2 ) with EC50 of 630 nM, and a weak antagonist peptide (Ac-WVFLIV-NH2) with IC50 of 15 nM., 21570128

  対象リソースIRI
• 2008, 2009, 20051004
• Assembly and Mechanism of Infection of Bacteriophage, ARISAKA Fumio; KANAMARU Shuji; TAKEDA Shigeki; MOH LAN Yap; NEMOTO Mai; TAHMINA Akhter; SUBODH Sarkar; ABURAI Kohei; MONZAKI Yasunori; OKUDA Mako; UCHIDA Kazuya; NAMURA Mikiyoshi; TERAUCHI Makoto; ITO Masako; HORIKOSHI Yusuke; FUJITA Daigo; SUGAI Shinnji; NAGAO Tatsuya; DONNY Sunanda; NAKAO Tomoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, Grant-in-Aid for Scientific Research on Priority Areas, Tokyo Institute of Technology, 2004, 2009, All the subunit proteins were localized in the baseplate before and after infection by a combination of X-ray crystallography and three-dimensional image econstruction from electron-micrographs. As a result, the gross structural change of the baseplate upon infection can be interpreted by the change of the relative positions of the subunits. Also, a new method was developed, which indicated that the stringent sequential assembly of the baseplate wedge is based on the induced-fit of the subunits upon binding., 16087204

  対象リソースIRI
• 2006, 2007, 18032016
• 2006, 2007, 18054005
• 2005, 2005, 17035013
• Structure and Assembly of the Contractile Tail of Bacteriophage, ARISAKA Fumio; KANAMARU SHUJI; TAKEDA SHIGEKI, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Tokyo Institute of Technology, 2003, 2005, The purpose of the present study is to elucidate the mechanism of assembly and function of bacteriophage as a model system in terms of its molecular and atomic level. The major results we obtained were the following : The most important progress in elucidating the mechanism of the structural transformation of the contractile tail of phage T4 came from the collaboration with Michael Rossmann's group at Purdue. Leiman in Rossmann's group succeeded in determining the low resolution structure of the contracted tail by 3D image reconstruction from cryo-EM. The fact that the same high resolution structure of the subunits can be fitted into the electron density of the contracted conformation indicates that the subunits themselves do not change their conformation significantly, but change the relative positions in the baseplate during conformational change of the baseplate. Using the extended and contracted images of the tail and interpolation, we were able obtain a reasonably detailed model of how the subunit rearrangement takes place. Gp11 strongly binds to the domain III and the N-terminus of gp12 which is the short tail fiber binds to domain IV of gp10 before structural change. The protein which plays a key role during the "hexagon" to "star" conformational change of the baseplate is gp10. Upon infection, as gp10 rotates around the longitudinal axis, gp11 which had been bound to gp12 now binds to gp34, the proximal long tail fiber, and the short tail fiber extends out from the bottom of the baseplate. Secondly, we have succeeded in elucidating the tail lysozyme (gp5) structure, where the amino acid at 351^ position was replaced with seven different amino acids. One of them, S351L, of which the cleavage was completely suppressed, was expressed, purified and crystallized for X-ray diffraction. The structure of the S351L mutant showed that the cleavage site was highly exposed, as would be required for efficient digestion during phage maturation. Since the structure of gp5 does not resemble any known protease, the cleavage is most likely not autocatalytic, but the result of an E.coli protease. The mutant structure further demonstrates that the inhibition peptide from the neighboring subunit is already at the substrate recognition site prior to cleavage., 15370065
• 2004, 2004, 16048202
• 2001, 2002, 12780579
• 1997, 1997, 09240210
• 1997, 1997, 09261207
• 1997, 1997, 09276205

Academic Contribution

• Academic society etc