Researcher Profile and Settings

Researcher

• Name

  Komatsu Tetsuro

Profile and Settings

• Name

  Komatsu, Tetsuro

Affiliation

• Gunma University, Institute for Molecular and Cellular Regulation

Education

• Apr. 2006, Nov. 2010
• Apr. 2004, Mar. 2006
• Apr. 2000, Mar. 2004, Kitasato University, School of Pharmaceutical Sciences

Research Experience

• Jun. 2020, 9999, Gunma University, Institute for Molecular and Cellular Regulation
• Apr. 2017, May 2020, Kyushu University, Medical Institute of Bioregulation
• Apr. 2015, Mar. 2017
• May 2012, Mar. 2015
• Dec. 2010, Mar. 2015, University of Tsukuba, Faculty of Medicine

Research Activities

Research Areas

• Life sciences, Molecular biology

Published Papers

• Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Akiko Tanioka; Diana Vargas; Reika Kawabata-Iwakawa; Fumihito Miura; Shinnosuke Masuda; Mayuko Hayashi; Kyoko Tanimura-Inagaki; Sumiyo Morita; Junki Kohmaru; Koji Adachi; Masayuki Tobo; Hideru Obinata; Tasuku Hirayama; Hiroshi Kimura; Juro Sakai; Hideko Nagasawa; Hideyuki Itabashi; Izuho Hatada; Takashi Ito; Takeshi Inagaki, 09 May 2023, Nucleic Acids Research, 51, 12, 6120, 6142, Scientific journal

  DOI
• Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant., Seiya Hirai; Kosuke Tomimatsu; Atsuko Miyawaki-Kuwakado; Yoshimasa Takizawa; Tetsuro Komatsu; Taro Tachibana; Yutaro Fukushima; Yasuko Takeda; Lumi Negishi; Tomoya Kujirai; Masako Koyama; Yasuyuki Ohkawa; Hitoshi Kurumizaka, 11 Jan. 2022, Nucleic acids research, 50, 1, 72, 91, Scientific journal

  DOI
• Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals., Tomohiro Suzuki; Mayuko Hayashi; Tetsuro Komatsu; Akiko Tanioka; Masahiro Nagasawa; Kyoko Tanimura-Inagaki; Mohammad Sharifur Rahman; Shinnosuke Masuda; Kosuke Yusa; Juro Sakai; Hiroshi Shibata; Takeshi Inagaki, 15 Jul. 2021, Endocrine journal, 68, 12, 1429, 1438, Scientific journal

  DOI
• Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1., Genoveso MJ; Hisaoka M; Komatsu T; Wodrich H; Nagata K; Okuwaki M, Jul. 2019, The FEBS journal

  DOI
• Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration, Akihito Harada; Kazumitsu Maehara; Yusuke Ono; Hiroyuki Taguchi; Kiyoshi Yoshioka; Yasuo Kitajima; Yan Xie; Yuko Sato; Takeshi Iwasaki; Jumpei Nogami; Seiji Okada; Tetsuro Komatsu; Yuichiro Semba; Tatsuya Takemoto; Hiroshi Kimura; Hitoshi Kurumizaka; Yasuyuki Ohkawa, 01 Dec. 2018, Nature Communications, 9, 1, 1400, Scientific journal

  DOI
• In Vivo Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication., Komatsu T; Quentin-Froignant C; Carlon-Andres I; Lagadec F; Rayne F; Ragues J; Kehlenbach RH; Zhang W; Ehrhardt A; Bystricky K; Morin R; Lagarde JM; Gallardo F; Wodrich H, Sep. 2018, Journal of virology, 92, 18

  DOI
• The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation, Kensuke Kudou; Tetsuro Komatsu; Jumpei Nogami; Kazumitsu Maehara; Akihito Harada; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara; Yasuyuki Ohkawa, Sep. 2017, OPEN BIOLOGY, 7, 9, Scientific journal

  DOI
• Tracking adenovirus genomes identifies morphologically distinct late DNA replication compartments, Tetsuro Komatsu; Derrick R. Robinson; Miharu Hisaoka; Shuhei Ueshima; Mitsuru Okuwaki; Kyosuke Nagata; Harald Wodrich, Nov. 2016, TRAFFIC, 17, 11, 1168, 1180, Scientific journal

  DOI
• The Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes, Tetsuro Komatsu; Kyosuke Nagata; Harald Wodrich, Oct. 2016, VIRUSES-BASEL, 8, 10

  DOI
• Imaging analysis of nuclear antiviral factors through direct detection of incoming adenovirus genome complexes, Tetsuro Komatsu; Hans Will; Kyosuke Nagata; Harald Wodrich, Apr. 2016, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 473, 1, 200, 205, Scientific journal

  DOI
• An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies, Tetsuro Komatsu; Kyosuke Nagata; Harald Wodrich, Feb. 2016, JOURNAL OF VIROLOGY, 90, 3, 1657, 1667, Scientific journal

  DOI
• A Method for Visualization of Incoming Adenovirus Chromatin Complexes in Fixed and Living Cells, Tetsuro Komatsu; Denis Dacheux; Florian Kreppel; Kyosuke Nagata; Harald Wodrich, Sep. 2015, PLOS ONE, 10, 9, e0137102, Scientific journal

  DOI
• DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions, Tetsuro Komatsu; Takeshi Sekiya; Kyosuke Nagata, Jul. 2013, SCIENTIFIC REPORTS, 3, 2187, Scientific journal

  DOI
• B23/nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in virus replication and transcription, Mohammad Abdus Samad; Tetsuro Komatsu; Mitsuru Okuwaki; Kyosuke Nagata, Jun. 2012, JOURNAL OF GENERAL VIROLOGY, 93, Pt 6, 1328, 1338, Scientific journal

  DOI
• Replication-Uncoupled Histone Deposition during Adenovirus DNA Replication, Tetsuro Komatsu; Kyosuke Nagata, Jun. 2012, JOURNAL OF VIROLOGY, 86, 12, 6701, 6711, Scientific journal

  DOI
• Cellular and viral chromatin proteins are positive factors in the regulation of adenovirus gene expression, Tetsuro Komatsu; Hirohito Haruki; Kyosuke Nagata, Feb. 2011, NUCLEIC ACIDS RESEARCH, 39, 3, 889, 901, Scientific journal

  DOI
• Changes in adenoviral chromatin organization precede early gene activation upon infection., Uwe Schwartz; Tetsuro Komatsu; Claudia Huber; Floriane Lagadec; Conradin Baumgartl; Elisabeth Silberhorn; Margit Nuetzel; Fabienne Rayne; Eugenia Basyuk; Edouard Bertrand; Michael Rehli; Harald Wodrich; Gernot Laengst, 29 Aug. 2023, The EMBO journal, e114162, Scientific journal

  DOI
• Iron-Dependent JMJD1A-Mediated Demethylation of H3K9me2 Regulates Gene Expression During Adipogenesis in a Spatial Genome Organization-Dependent Manner., Shinnosuke Masuda; Tetsuro Komatsu; Safiya Atia; Tomohiro Suzuki; Mayuko Hayashi; Atsushi Toyoda; Hiroshi Kimura; Takeshi Inagaki, May 2025, Genes to Cells, 30, 3, e70023, Scientific journal

  DOI
• Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I., Miharu Hisaoka; Tetsuro Komatsu; Takuma Hashimoto; Jianhuang Lin; Yasuyuki Ohkawa; Mitsuru Okuwaki, 27 Mar. 2025, Epigenetics & chromatin, 18, 1, 14, 14, Scientific journal

  DOI

MISC

• 病態と細胞核 4.ウイルス感染と細胞核・クロマチン, 加藤広介; 浅賀正充; 小松哲郎; 加藤有香; 永田恭介, 2009, 27, 17
• Metabolic Responses to Energy-Depleted Conditions, Tomohiro Suzuki; Tetsuro Komatsu; Hiroshi Shibata; Takeshi Inagaki, 01 Dec. 2021, Psychology and Pathophysiological Outcomes of Eating

  DOI
• Epigenome profiling technology for spatially resolved analysis, 小松哲郎; 大川恭行, 2020, 月刊細胞, 52, 6
• 骨格筋の発生と再生 4.クロマチン構造が規定する骨格筋分化, 小松哲郎; 大川恭行, 2018, 36, 7
• 分子機構論 2.ヒストンシャペロン, 奥脇暢; 小松哲郎; 永田恭介, 2007, 25, 10

Awards

• 2022

Research Projects

• 01 Apr. 2023, 31 Mar. 2026, 23K07983

  対象リソースIRI
• 01 Apr. 2019, 31 Mar. 2021, 19H04838

  対象リソースIRI
• Functional analysis of histone H3.3 sub-variants in skeletal muscle regeneration, Komatsu Tetsuro, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Kyushu University, 01 Apr. 2018, 31 Mar. 2020, Histone variant H3.3 plays a critical role in regulating gene expression during development and differentiation. In this study, we analyzed the role of H3mm18, one of the “H3.3 sub-variants” expressed in skeletal muscle. Transcriptome analysis using mouse samples as well as culture cells revealed that H3mm18 regulates expression levels of myogenic genes upon skeletal muscle regeneration and/or differentiation. Furthermore, biochemical experiments suggested that H3mm18 itself is not stably incorporated into chromatin but regulates myogenic chromatin structure by competing with H3.3 in histone deposition., 18K16664

  対象リソースIRI
• 01 Apr. 2024, 31 Mar. 2026, 24H01222

  対象リソースIRI
• Nov. 2024, Mar. 2029, Principal investigator
• Apr. 2025, Mar. 2027, Principal investigator
• Sep. 2024, Dec. 2025, Principal investigator
• Oct. 2024, Oct. 2025, Principal investigator
• Apr. 2024, Mar. 2025, Principal investigator
• Apr. 2023, Mar. 2024, Principal investigator
• Apr. 2023, Mar. 2024, Principal investigator
• Apr. 2023, Mar. 2024, Principal investigator
• Oct. 2022, Mar. 2023, Principal investigator

Social Contribution

Social Contribution

• 群馬大学 最先端生命科学セミナー, 11 Mar. 2023, 11 Mar. 2023
• 分野研究紹介動画配信, 30 Mar. 2022　(Target:　General)
• 群馬大学 最先端生命科学セミナー, 20 Mar. 2021　(Target:　High school students)