Researcher Profile and Settings

Researcher

• Name

  Ohnishi HIROSHI

Affiliation

• Laboratory Science, Professor

Profile and Settings

• Name

  Ohnishi, Hiroshi

ホームページ

• URI

  http://biosignal.dept.med.gunma-u.ac.jp/, Laboratory of Biosignal Sciences

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Graduate School of Health Sciences
• Gunma University, Graduate School of Health Sciences
• Kobe University

Affiliation

• Affiliation

  Graduate School of Gealth Science

• Job title

  Professor

Education

• Apr. 1990, Mar. 1993
• Apr. 1988, Mar. 1990
• Apr. 1984, Mar. 1988

Degree

• PhD
• PhD

Association Memberships

• Japanese Association for Protein Phosphatase Research
• Kitakanto Medical Society
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• Society for Neuroscience
• THE JAPANESE CANCER ASSOCIATION
• THE JAPANESE BIOCHEMICAL SOCIETY
• THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
• THE JAPAN NEUROSCIENCE SOCIETY
• International Society of Radiation Neurobiology

Research Experience

• 2013, 9999, Gunma University, Graduate School of Health Science, Professor
• 1992, 1993, JSPS Post Doctoral Fellow
• 2006, 2007, Gunma University, Institute for Molecular and Cellular Regulation
• 2001, 2005, Gunma University, Institute for Molecular and Cellular Regulation
• 1993, 1997
• 1997, 2001
• 2007, 2012, Gunma University, Institute for Molecular and Cellular Regulation

Joint research and hope theme

• Regulation of neuronal functions by protein tyrosine phosphorylation., Industry-academia Collaboration, Technical consulting:Impossible, Joint Research:Possible, Others:Impossible

Research Activities

Research Areas

• Life sciences, Nutrition and health science
• Life sciences, Neuroscience - general

Research Interests

• Immunity
• thermal biology
• genetically modified mouse
• behavior
• Rasopathy
• neural network
• phosphatase
• protein phosphorylation
• synapse
• neuroimmunology
• microglia
• aging

Research Themes

• Tyrosine phosphorylation and synaptic plasticity, tyrosine phosphorylation,synapse,synaptic plasticity, Institutional Collaboration, Nerve Chemistry/ Nerve Pharmacology, Grant-in-Aid for Scientific Research

Published Papers

• Q241R mutation of Braf causes neurological abnormalities in a mouse model of cardio-facio-cutaneous syndrome, independent of developmental malformations, Akira Moriya, Shin-ichi Inoue, Fumihito Saitow, Moe Keitoku, Noato Suzuki, Etsumi Oike, Eriko Urano, Eiko Matsumoto, Hidenori Suzuki, Yoko Aoki, Hiroshi Ohnishi, 08 Jan. 2025, Human Molecular Genetics, 34, 5, 418, 434, Scientific journal

  DOI
• CD47 promotes peripheral T cell survival by preventing dendritic cell–mediated T cell necroptosis, Satomi Komori, Yasuyuki Saito, Taichi Nishimura, Datu Respatika, Hiromi Endoh, Hiroki Yoshida, Risa Sugihara, Rie Iida-Norita, Tania Afroj, Tomoko Takai, Okechi S. Oduori, Eriko Nitta, Takenori Kotani, Yoji Murata, Yoriaki Kaneko, Ryo Nitta, Hiroshi Ohnishi, Takashi Matozaki, 07 Aug. 2023, Proceedings of the National Academy of Sciences, 120, 3, e2304943120, Scientific journal

  DOI
• SIRPα on CD11c+ cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis, Taichi Nishimura; Yasuyuki Saito; Ken Washio; Satomi Komori; Datu Respatika; Takenori Kotani; Yoji Murata; Hiroshi Ohnishi; Satoshi Mizobuchi; Takashi Matozaki, Oct. 2020, European Journal of Immunology, 50, 10, 1560, 1570, Scientific journal

  DOI
• Importance of methodology in the evaluation of renal mononuclear phagocytes and analysis of a model of experimental nephritis with Shp1 conditional knockout mice, Mitsuharu Watanabe; Yoriaki Kaneko; Yuko Ohishi; Masato Kinoshita; Toru Sakairi; Hidekazu Ikeuchi; Akito Maeshima; Yasuyuki Saito; Hiroshi Ohnishi; Yoshihisa Nojima; Takashi Matozaki; Keiju Hiromura, Jul. 2020, Biochemistry and Biophysics Reports, 22, 100741, 100741, Scientific journal

  DOI
• Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter, Sato-Hashimoto M; Nozu T; Toriba R; Horikoshi A; Akaike M; Kawamoto K; Hirose A; Hayashi H; Nagai H; Shimizu W; Saiki A; Ishikawa T; Elhanbaly R; Kotani T; Murata Y; Saito Y; Naruse M; Shibasaki K; Oldenborg P.-A; Jung S; Matozaki T; Fukazawa Y; Ohnishi H, Oct. 2018, bioRxiv, Scientific journal

  DOI
• Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter., Sato-Hashimoto Miho;Nozu Tomomi;Toriba Riho;Horikoshi Ayano;Akaike Miho;Kawamoto Kyoko;Hirose Ayaka;Hayashi Yuriko;Nagai Hiromi;Shimizu Wakana;Saiki Ayaka;Ishikawa Tatsuya;Elhanbly Ruwaida;Kotani Takenori;Murata Yoji;Saito Yasuyuki;Naruse Masae;Shibasaki Koji;Oldenborg Per-Arne;Jung Steffen;Matozaki Takashi;Fukazawa Yugo;Ohnishi Hiroshi, 26 Mar. 2019, eLife, 8, Scientific journal

  DOI
• Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health Study, Alkebsi Lobna;Ohnishi Hiroshi;Nakajima-Shimada Junko;Onizuka Yoko;Ideno Yuki;Sato Yasunori;Hayashi Kunihiko, 26 Mar. 2019, Asian Pacific Journal of Cancer Prevention : APJCP, 20, 3, Scientific journal

  DOI
• Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses’ Health Study (JNHS), Lobna Alkebsi; Yuki Ideno; Jung-Su Lee; Shosuke Suzuki; Junko Nakajima-Shimada; Hiroshi Ohnishi; Yasunori Sato; Kunihiko Hayashi, 05 Jan. 2018, Journal of Epidemiology, 28, 1, 34, 40, Scientific journal

  DOI
• SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen., Saito Yasuyuki;Respatika Datu;Komori Satomi;Washio Ken;Nishimura Taichi;Kotani Takenori;Murata Yoji;Okazawa Hideki;Ohnishi Hiroshi;Kaneko Yoriaki;Yui Katsuyuki;Yasutomo Koji;Nishigori Chikako;Nojima Yoshihisa;Matozaki Takashi, 06 Nov. 2017, Proceedings of the National Academy of Sciences of the United States of America, 114, 47

  DOI
• Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy., Yanagita T; Murata Y; Tanaka D; Motegi S; Arai E; Daniwijaya E.W; Hazama D; Washio K; Saito Y; Kotani T; Ohnishi H; Oldenborg P.-A; Garcia N.V; Miyasaka M; Ishikawa O; Kanai Y; Komori T; Matozaki T, 12 Jan. 2017, JCI Insight, 2, 1, e89140, Scientific journal

  DOI
• SIRP alpha(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen, Saito, Yasuyuki;Komori, Satomi;Respatika, Datu;Washio, Ken;Kotani, Takenori;Murata, Yoji;Ohnishi, Hiroshi;Yui, Katsuyuki;Yasutomo, Koji;Matozaki, Takashi, 2017, CYTOKINE, 100, 55, 55
• Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment, Koichi Sakakura; Hideyuki Takahashi; Kyoichi Kaira; Minoru Toyoda; Takaaki Murata; Hiroshi Ohnishi; Tetsunari Oyama; Kazuaki Chikamatsu, Sep. 2016, LABORATORY INVESTIGATION, 96, 9, 994, 1003, Scientific journal

  DOI
• Relationship between tumor-Associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment, Koichi Sakakura; Hideyuki Takahashi; Kyoichi Kaira; Minoru Toyoda; Takaaki Murata; Hiroshi Ohnishi; Tetsunari Oyama; Kazuaki Chikamatsu, 01 Sep. 2016, Laboratory Investigation, 96, 9, 994, 1003, Scientific journal

  DOI
• Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment., Sakakura Koichi;Takahashi Hideyuki;Kaira Kyoichi;Toyoda Minoru;Murata Takaaki;Ohnishi Hiroshi;Oyama Tetsunari;Chikamatsu Kazuaki, 20 Jun. 2016, Laboratory investigation; a journal of technical methods and pathology, 96, 9, 994, 1003, Scientific journal

  DOI
• Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment, Sakakura, Koichi;Takahashi, Hideyuki;Kaira, Kyoichi;Toyoda, Minoru;Murata, Takaaki;Ohnishi, Hiroshi;Oyama, Tetsunari;Chikamatsu, Kazuaki, 2016, LABORATORY INVESTIGATION, 96, 9, 994, 1003

  DOI
• Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype., Mitsuji Moriya; Shin-Ichi Inoue; Sachiko Miyagawa-Tomita; Yasumi Nakashima; Daiju Oba; Tetsuya Niihori; Misato Hashi; Hiroshi Ohnishi; Shigeo Kure; Yoichi Matsubara; Yoko Aoki, 20 Dec. 2015, Human molecular genetics, 24, 25, 7349, 60, Scientific journal

  DOI
• Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium, Yoji Murata; Takenori Kotani; Yana Supriatna; Yasuaki Kitamura; Shinya Imada; Kohichi Kawahara; Miki Nishio; Edwin Widyanto Daniwijaya; Hisanobu Sadakata; Shinya Kusakari; Munemasa Mori; Yoshitake Kanazawa; Yasuyuki Saito; Katsuya Okawa; Mariko Takeda-Morishita; Hideki Okazawa; Hiroshi Ohnishi; Takeshi Azuma; Akira Suzuki; Takashi Matozaki, Aug. 2015, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 31, E4264, E4271, Scientific journal

  DOI
• ミクログリアにおけるSIRPαシグナルの役割, 橋本 美穂;野津 智美;浦野 江里子;齊藤 泰之;小谷 武徳;村田 陽二;的崎 尚;大西 浩史, Aug. 2015, 65, 3, 270, 271
• Dendritic cell SIRP regulates homeostasis of dendritic cells in lymphoid organs, Ken Washio; Takenori Kotani; Yasuyuki Saito; Datu Respatika; Yoji Murata; Yoriaki Kaneko; Hideki Okazawa; Hiroshi Ohnishi; Atsushi Fukunaga; Chikako Nishigori; Takashi Matozaki, Jun. 2015, GENES TO CELLS, 20, 6, 451, 463, Scientific journal

  DOI
• Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs, Ken Washio; Takenori Kotani; Yasuyuki Saito; Datu Respatika; Yoji Murata; Yoriaki Kaneko; Hideki Okazawa; Hiroshi Ohnishi; Atsushi Fukunaga; Chikako Nishigori; Takashi Matozaki, 01 Jun. 2015, Genes to Cells, 20, 6, 451, 463, Scientific journal

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Shinya Kusakari; Fumihito Saitow; Yukio Ago; Koji Shibasaki; Miho Sato-Hashimoto; Yasunori Matsuzaki; Takenori Kotani; Yoji Murata; Hirokazu Hirai; Toshio Matsuda; Hidenori Suzuki; Takashi Matozaki; Hiroshi Ohnishi, May 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572, Scientific journal

  DOI
• Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst, Xing Jun Li; Charles B G Oodwin; Sarah C. Nabinger; Briana M. Richine; Zhenyun Yang; Helmut Hanenberg; Hiroshi Ohnishi; Takashi Matozaki; Gen-Sheng Feng; Rebecca J. Chan, 13 Feb. 2015, Journal of Biological Chemistry, 290, 7, 3894, 3909, Scientific journal

  DOI
• Pathogenesis of Multiple Lentigines in LEOPARD Syndrome with PTPN11 Gene Mutation, Sei-ichiro Motegi; Yoko Yokoyama; Sachiko Ogino; Kazuya Yamada; Akihiko Uchiyama; Buddhini Perera; Yuko Takeuchi; Hiroshi Ohnishi; Osamu Ishikawa, 2015, ACTA DERMATO-VENEREOLOGICA, 95, 8, 978, 984, Scientific journal

  DOI
• ミクログリアを制御する細胞間相互作用シグナル, 橋本美穂; 大西浩史, 2015, Clinical Neuroscience, 33, 1350, 1353
• Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst, Li, Xing Jun;Goodwin, Charles B.;Nabinger, Sarah C.;Richine, Briana M.;Yang, Zhenyun;Hanenberg, Helmut;Ohnishi, Hiroshi;Matozaki, Takashi;Feng, Gen-Sheng;Chan, Rebecca J., 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 7, 3894, 3909

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Kusakari, Shinya;Saitow, Fumihito;Ago, Yukio;Shibasaki, Koji;Sato-Hashimoto, Miho;Matsuzaki, Yasunori;Kotani, Takenori;Murata, Yoji;Hirai, Hirokazu;Matsuda, Toshio;Suzuki, Hidenori;Matozaki, Takashi;Ohnishi, Hiroshi, 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572

  DOI
• Dendritic cell SIRP regulates homeostasis of dendritic cells in lymphoid organs, Washio, Ken;Kotani, Takenori;Saito, Yasuyuki;Respatika, Datu;Murata, Yoji;Kaneko, Yoriaki;Okazawa, Hideki;Ohnishi, Hiroshi;Fukunaga, Atsushi;Nishigori, Chikako;Matozaki, Takashi, 2015, GENES TO CELLS, 20, 6, 451, 463

  DOI
• Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium, Murata, Yoji;Kotani, Takenori;Supriatna, Yana;Kitamura, Yasuaki;Imada, Shinya;Kawahara, Kohichi;Nishio, Miki;Daniwijaya, Edwin Widyanto;Sadakata, Hisanobu;Kusakari, Shinya;Mori, Munemasa;Kanazawa, Yoshitake;Saito, Yasuyuki;Okawa, Katsuya;Takeda-Morishita, Mariko;Okazawa, Hideki;Ohnishi, Hiroshi;Azuma, Takeshi;Suzuki, Akira;Matozaki, Takashi, 2015, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112, 31, E4264, E4271

  DOI
• Pathogenesis of Multiple Lentigines in LEOPARD Syndrome with PTPN11 Gene Mutation, Motegi, Sei-ichiro;Yokoyama, Yoko;Ogino, Sachiko;Yamada, Kazuya;Uchiyama, Akihiko;Perera, Buddhini;Takeuchi, Yuko;Ohnishi, Hiroshi;Ishikawa, Osamu, 2015, ACTA DERMATO-VENEREOLOGICA, 95, 8, 978, 984

  DOI
• Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype, Moriya, Mitsuji;Inoue, Shin-ichi;Miyagawa-Tomita, Sachiko;Nakashima, Yasumi;Oba, Daiju;Niihori, Tetsuya;Hashi, Misato;Ohnishi, Hiroshi;Kure, Shigeo;Matsubara, Yoichi;Aoki, Yoko, 2015, HUMAN MOLECULAR GENETICS, 24, 25, 7349, 7360

  DOI
• The CD47-SIRPα signalling system: Its physiological roles and therapeutic application, Yoji Murata; Takenori Kotani; Hiroshi Ohnishi; Takashi Matozaki, 2014, Journal of Biochemistry, 155, 6, 335, 344, Scientific journal

  DOI
• Shear stress-induced redistribution of vascular endothelial-protein- tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation, Kemala Isnainiasih Mantilidewi; Yoji Murata; Munemasa Mori; Chihiro Otsubo; Takenori Kotani; Shinya Kusakari; Hiroshi Ohnishi; Takashi Matozaki, 07 Mar. 2014, Journal of Biological Chemistry, 289, 10, 6451, 6461, Scientific journal

  DOI
• Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium, Hironori Yamashita; Takenori Kotani; Jung-ha Park; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Yonson Ku; Takashi Matozaki, Mar. 2014, PLOS ONE, 9, 3, e92904, Scientific journal

  DOI
• Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice, Hisatsugu Koshimizu; Keizo Takao; Takashi Matozaki; Hiroshi Ohnishi; Tsuyoshi Miyakawa, Feb. 2014, PLOS ONE, 9, 2, e89584, Scientific journal

  DOI
• Autoimmune animal models in the analysis of the CD47-SIRP alpha signaling pathway, Yoji Murata; Yasuyuki Saito; Tetsuya Kaneko; Takenori Kotani; Yoriaki Kaneko; Hiroshi Ohnishi; Takashi Matozaki, Jan. 2014, METHODS, 65, 2, 254, 259, Scientific journal

  DOI
• 膜型分子CD47とSIRPαによる細胞間接触シグナルと脳内環境制御, 大西浩史; 橋本美穂, 2014, 脳内環境ー維持機構と破綻がもたらす疾患研究（遺伝子医学MOOK 26号）, 114, 118
• A Novel Signaling Mechanism in the Brain, Ohnishi Hiroshi, 2014, The Kitakanto Medical Journal, 64, 4, 349, 350
• The CD47-SIRP alpha signalling system: its physiological roles and therapeutic application, Murata, Yoji;Kotani, Takenori;Ohnishi, Hiroshi;Matozaki, Takashi, 2014, JOURNAL OF BIOCHEMISTRY, 155, 6, 335, 344

  DOI
• Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium, Yamashita, Hironori;Kotani, Takenori;Park, Jung-ha;Murata, Yoji;Okazawa, Hideki;Ohnishi, Hiroshi;Ku, Yonson;Matozaki, Takashi, 2014, PLOS ONE, 9, 3

  DOI
• Shear Stress-induced Redistribution of Vascular Endothelial-Protein-tyrosine Phosphatase (VE-PTP) in Endothelial Cells and Its Role in Cell Elongation, Mantilidewi, Kemala Isnainiasih;Murata, Yoji;Mori, Munemasa;Otsubo, Chihiro;Kotani, Takenori;Kusakari, Shinya;Ohnishi, Hiroshi;Matozaki, Takashi, 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 10, 6451, 6461

  DOI
• Autoimmune animal models in the analysis of the CD47-SIRP alpha signaling pathway, Murata, Yoji;Saito, Yasuyuki;Kaneko, Tetsuya;Kotani, Takenori;Kaneko, Yoriaki;Ohnishi, Hiroshi;Matozaki, Takashi, 2014, METHODS, 65, 2, 254, 259

  DOI
• Comprehensive Behavioral Analysis of Cluster of Differentiation 47 Knockout Mice, Koshimizu, Hisatsugu;Takao, Keizo;Matozaki, Takashi;Ohnishi, Hiroshi;Miyakawa, Tsuyoshi, 2014, PLOS ONE, 9, 2

  DOI
• SIRP alpha signaling regulates podocyte structure and function, Satoshi Takahashi; Mai Tomioka; Keiju Hiromura; Toru Sakairi; Hiroko Hamatani; Mitsuharu Watanabe; Hidekazu Ikeuchi; Yoriaki Kaneko; Akito Maeshima; Takeo Aoki; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima, Sep. 2013, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 305, 6, F861, F870, Scientific journal

  DOI
• タンパク質チロシンリン酸化シグナルによる脳機能・行動の制御, 大西 浩史, Aug. 2013, 63, 3, 312, 312
• ＳＩＲＰαによる脾臓Ｔ細胞の恒常性の調節, 橋本 美穂;齊藤 泰之;金子 哲也;大西 浩史;草刈 伸也;小谷 武徳;村田 陽二;岡澤 秀樹 的崎 尚, Aug. 2013, 63, 3, 326, 327
• 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析, Neel Benjamin G., Aug. 2013, 63, 3, 321, 322
• Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role., Daniwijaya Edwin Widyanto;Murata Yoji;Kotani Takenori;Kitamura Yasuaki;Mantilidewi Kemala Isnainiasih;Kusakari Shinya;Ohnishi Hiroshi;Okazawa Hideki;Matozaki Takashi, 03 Mar. 2013, The Kobe journal of medical sciences, 59, 5
• Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state, Ke Zen; Yalan Guo; Zhen Bian; Zhiyuan Lv; Dihan Zhu; Hiroshi Ohnishi; Takashi Matozaki; Yuan Liu, 2013, Nature Communications, 4, 2436, Scientific journal

  DOI
• SIRP alpha signaling regulates podocyte structure and function, Takahashi, Satoshi;Tomioka, Mai;Hiromura, Keiju;Sakairi, Toru;Hamatani, Hiroko;Watanabe, Mitsuharu;Ikeuchi, Hidekazu;Kaneko, Yoriaki;Maeshima, Akito;Aoki, Takeo;Ohnishi, Hiroshi;Matozaki, Takashi;Nojima, Yoshihisa, 2013, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 305, 6, F861, F870

  DOI
• Inflammation-induced proteolytic processing of the SIRP alpha cytoplasmic ITIM in neutrophils propagates a proinflammatory state, Zen, Ke;Guo, Yalan;Bian, Zhen;Lv, Zhiyuan;Zhu, Dihan;Ohnishi, Hiroshi;Matozaki, Takashi;Liu, Yuan, 2013, NATURE COMMUNICATIONS, 4

  DOI
• Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus, Yuriko Hayashi; Shinya Kusakari; Miho Sato-Hashimoto; Eriko Urano; Masahiro Shigeno; Tsuneo Sekijima; Takenori Kotani; Yoji Murata; Hirokazu Murakami; Takashi Matozaki; Hiroshi Ohnishi, Nov. 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 428, 4, 475, 481, Scientific journal

  DOI
• Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion, Takashi Nakakura; Chihiro Mogi; Masayuki Tobo; Hideaki Tomura; Koichi Sato; Masaki Kobayashi; Hiroshi Ohnishi; Shigeyasu Tanaka; Mitsutoshi Wayama; Tetsuya Sugiyama; Tadahiro Kitamura; Akihiro Harada; Fumikazu Okajima, Sep. 2012, ENDOCRINOLOGY, 153, 9, 4171, 4180, Scientific journal

  DOI
• SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress, Lang Wang; Yanyun Lu; Shan Deng; Yan Zhang; Li Yang; Yu Guan; Takashi Matozaki; Hiroshi Ohnishi; Hong Jiang; Hongliang Li, Aug. 2012, JOURNAL OF NEUROCHEMISTRY, 122, 4, 834, 843, Scientific journal

  DOI
• Hypothermia-induced tyrosine phosphorylation of SIRPa in the brain, Toshi Maruyama; Shinya Kusakari; Miho Sato-Hashimoto; Yuriko Hayashi; Takenori Kotani; Yoji Murata; Hideki Okazawa; Per-Arne Oldenborg; Shoji Kishi; Takashi Matozaki; Hiroshi Ohnishi, Jun. 2012, JOURNAL OF NEUROCHEMISTRY, 121, 6, 891, 902, Scientific journal

  DOI
• Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity, Tetsuya Kaneko; Yasuyuki Saito; Takenori Kotani; Hideki Okazawa; Hiroko Iwamura; Miho Sato-Hashimoto; Yoshitake Kanazawa; Satoshi Takahashi; Keiju Hiromura; Shinya Kusakari; Yoriaki Kaneko; Yoji Murata; Hiroshi Ohnishi; Yoshihisa Nojima; Kenji Takagishi; Takashi Matozaki, Jun. 2012, JOURNAL OF IMMUNOLOGY, 188, 11, 5397, 5407, Scientific journal

  DOI
• SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress, Wang, Lang;Lu, Yanyun;Deng, Shan;Zhang, Yan;Yang, Li;Guan, Yu;Matozaki, Takashi;Ohnishi, Hiroshi;Jiang, Hong;Li, Hongliang, 2012, JOURNAL OF NEUROCHEMISTRY, 122, 4, 834, 843

  DOI
• Hypothermia-induced tyrosine phosphorylation of SIRPa in the brain, Maruyama, Toshi;Kusakari, Shinya;Sato-Hashimoto, Miho;Hayashi, Yuriko;Kotani, Takenori;Murata, Yoji;Okazawa, Hideki;Oldenborg, Per-Arne;Kishi, Shoji;Matozaki, Takashi;Ohnishi, Hiroshi, 2012, JOURNAL OF NEUROCHEMISTRY, 121, 6, 891, 902

  DOI
• Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity, Kaneko, Tetsuya;Saito, Yasuyuki;Kotani, Takenori;Okazawa, Hideki;Iwamura, Hiroko;Sato-Hashimoto, Miho;Kanazawa, Yoshitake;Takahashi, Satoshi;Hiromura, Keiju;Kusakari, Shinya;Kaneko, Yoriaki;Murata, Yoji;Ohnishi, Hiroshi;Nojima, Yoshihisa;Takagishi, Kenji;Matozaki, Takashi, 2012, JOURNAL OF IMMUNOLOGY, 188, 11, 5397, 5407

  DOI
• Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion, Nakakura, Takashi;Mogi, Chihiro;Tobo, Masayuki;Tomura, Hideaki;Sato, Koichi;Kobayashi, Masaki;Ohnishi, Hiroshi;Tanaka, Shigeyasu;Wayama, Mitsutoshi;Sugiyama, Tetsuya;Kitamura, Tadahiro;Harada, Akihiro;Okajima, Fumikazu, 2012, ENDOCRINOLOGY, 153, 9, 4171, 4180

  DOI
• Hypothermia-dependent and -independent effects of forced swim on the phosphorylation states of signaling molecules in mouse hippocampus, Hayashi, Yuriko;Kusakari, Shinya;Sato-Hashimoto, Miho;Urano, Eriko;Shigeno, Masahiro;Sekijima, Tsuneo;Kotani, Takenori;Murata, Yoji;Murakami, Hirokazu;Matozaki, Takashi;Ohnishi, Hiroshi, 2012, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 428, 4, 475, 481

  DOI
• Src family kinases: modulators of neurotransmitter receptor function and behavior, Hiroshi Ohnishi; Yoji Murata; Hideki Okazawa; Takashi Matozaki, Dec. 2011, TRENDS IN NEUROSCIENCES, 34, 12, 629, 637, Scientific journal

  DOI
• Regulation of the adult brain function by Src family tyrosine kinases, OHNISHI Hiroshi, Nov. 2011, 83, 11, 1054, 1059
• SIRPαは腎糸球体上皮細胞の形態と蛋白尿制御に関与する, 高橋 哲史;廣村 桂樹;富岡 麻衣;浜谷 博子;坂入 徹;青木 武生;大西 浩史;的崎 尚;野島 美久, Aug. 2011, The Kitakanto medical journal, 61, 3, 457, 457
• Signal Regulatory Protein alpha Regulates the Homeostasis of T Lymphocytes in the Spleen, Miho Sato-Hashimoto; Yasuyuki Saito; Hiroshi Ohnishi; Hiroko Iwamura; Yoshitake Kanazawa; Tetsuya Kaneko; Shinya Kusakari; Takenori Kotani; Munemasa Mori; Yoji Murata; Hideki Okazawa; Carl F. Ware; Per-Arne Oldenborg; Yoshihisa Nojima; Takashi Matozaki, Jul. 2011, JOURNAL OF IMMUNOLOGY, 187, 1, 291, 297, Scientific journal

  DOI
• Essential roles of SIRP alpha in homeostatic regulation of skin dendritic cells, Hiroko Iwamura; Yasuyuki Saito; Miho Sato-Hashimoto; Hiroshi Ohnishi; Yoji Murata; Hideki Okazawa; Yoshitake Kanazawa; Tetsuya Kaneko; Shinya Kusakari; Takenori Kotani; Yoshihisa Nojima; Takashi Matozaki, Mar. 2011, IMMUNOLOGY LETTERS, 135, 1-2, 100, 107, Scientific journal

  DOI
• Roles of protein tyrosine phosphatase SHPs and their related molecules in promotion and elimination of cancer cells, 岡澤 秀樹;大西 浩史, 2011, Cell technology, 30, 6, 619, 623
• Src family kinases: modulators of neurotransmitter receptor function and behavior, Ohnishi, Hiroshi;Murata, Yoji;Okazawa, Hideki;Matozaki, Takashi, 2011, TRENDS IN NEUROSCIENCES, 34, 12, 629, 637

  DOI
• Signal Regulatory Protein alpha Regulates the Homeostasis of T Lymphocytes in the Spleen, Sato-Hashimoto, Miho;Saito, Yasuyuki;Ohnishi, Hiroshi;Iwamura, Hiroko;Kanazawa, Yoshitake;Kaneko, Tetsuya;Kusakari, Shinya;Kotani, Takenori;Mori, Munemasa;Murata, Yoji;Okazawa, Hideki;Ware, Carl F.;Oldenborg, Per-Arne;Nojima, Yoshihisa;Matozaki, Takashi, 2011, JOURNAL OF IMMUNOLOGY, 187, 1, 291, 297

  DOI
• Essential roles of SIRP alpha in homeostatic regulation of skin dendritic cells, Iwamura, Hiroko;Saito, Yasuyuki;Sato-Hashimoto, Miho;Ohnishi, Hiroshi;Murata, Yoji;Okazawa, Hideki;Kanazawa, Yoshitake;Kaneko, Tetsuya;Kusakari, Shinya;Kotani, Takenori;Nojima, Yoshihisa;Matozaki, Takashi, 2011, IMMUNOLOGY LETTERS, 135, 1-2, 100, 107

  DOI
• Regulation by protein tyrosine phosphorylation of depression-like behavior, Ohnishi, Hiroshi;Matozaki, Takashi, 2011, NEUROSCIENCE RESEARCH, 71, E36, E36

  DOI
• Role of SIRP alpha in regulation of mucosal immunity in the intestine, Yoshitake Kanazawa; Yasuyuki Saito; Yana Supriatna; Hiroyuki Tezuka; Takenori Kotani; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Yoshitaka Kinouchi; Yoshihisa Nojima; Toshiaki Ohteki; Tooru Shimosegawa; Takashi Matozaki, Dec. 2010, GENES TO CELLS, 15, 12, 1189, 1200, Scientific journal

  DOI
• Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals, Takashi Matozaki; Yoji Murata; Munemasa Mori; Takenori Kotani; Hideki Okazawa; Hiroshi Ohnishi, Dec. 2010, CELLULAR SIGNALLING, 22, 12, 1811, 1817, Scientific journal

  DOI
• Regulation by SIRP alpha of dendritic cell homeostasis in lymphoid tissues, Yasuyuki Saito; Hiroko Iwamura; Tetsuya Kaneko; Hiroshi Ohnishi; Yoji Murata; Hideki Okazawa; Yoshitake Kanazawa; Miho Sato-Hashimoto; Hisae Kobayashi; Per-Arne Oldenborg; Makoto Naito; Yoriaki Kaneko; Yoshihisa Nojima; Takashi Matozaki, Nov. 2010, BLOOD, 116, 18, 3517, 3525, Scientific journal

  DOI
• Requirement of SIRP alpha for protective immunity against Leishmania major, Naoko Morimoto; Yoji Murata; Sei-ichiro Motegi; Kazutomo Suzue; Yasuyuki Saito; Hideki Okazawa; Hiroshi Ohnishi; Takenori Kotani; Shinya Kusakari; Osamu Ishikawa; Takashi Matozaki, Oct. 2010, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 401, 3, 385, 389, Scientific journal

  DOI
• Stress-Evoked Tyrosine Phosphorylation of Signal Regulatory Protein alpha Regulates Behavioral Immobility in the Forced Swim Test, Hiroshi Ohnishi; Takaaki Murata; Shinya Kusakari; Yuriko Hayashi; Keizo Takao; Toshi Maruyama; Yukio Ago; Ken Koda; Feng-Jie Jin; Katsuya Okawa; Per-Arne Oldenborg; Hideki Okazawa; Yoji Murata; Nobuhiko Furuya; Toshio Matsuda; Tsuyoshi Miyakawa; Takashi Matozaki, Aug. 2010, JOURNAL OF NEUROSCIENCE, 30, 31, 10472, 10483, Scientific journal

  DOI
• Promotion of Cell Spreading and Migration by Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP) in Cooperation With Integrins, Munemasa Mori; Yoji Murata; Takenori Kotani; Shinya Kusakari; Hiroshi Ohnishi; Yasuyuki Saito; Hideki Okazawa; Tamotsu Ishizuka; Masatomo Mori; Takashi Matozaki, Jul. 2010, JOURNAL OF CELLULAR PHYSIOLOGY, 224, 1, 195, 204, Scientific journal

  DOI
• Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn, Yoji Murata; Munemasa Mori; Takenori Kotani; Yana Supriatna; Hideki Okazawa; Shinya Kusakari; Yasuyuki Saito; Hiroshi Ohnishi; Takashi Matozaki, May 2010, GENES TO CELLS, 15, 5, 513, 524, Scientific journal

  DOI
• Expression of PTPRO in the Interneurons of Adult Mouse Olfactory Bulb, Takenori Kotani; Yoji Murata; Hiroshi Ohnishi; Munemasa Mori; Shinya Kusakari; Yasuyuki Saito; Hideki Kazawa; John L. Bixby; Takashi Matozaki, Jan. 2010, JOURNAL OF COMPARATIVE NEUROLOGY, 518, 2, 119, 136, Scientific journal

  DOI
• Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals, Matozaki, Takashi;Murata, Yoji;Mori, Munemasa;Kotani, Takenori;Okazawa, Hideki;Ohnishi, Hiroshi, 2010, CELLULAR SIGNALLING, 22, 12, 1811, 1817

  DOI
• Regulation by SIRP alpha of dendritic cell homeostasis in lymphoid tissues, Saito, Yasuyuki;Iwamura, Hiroko;Kaneko, Tetsuya;Ohnishi, Hiroshi;Murata, Yoji;Okazawa, Hideki;Kanazawa, Yoshitake;Sato-Hashimoto, Miho;Kobayashi, Hisae;Oldenborg, Per-Arne;Naito, Makoto;Kaneko, Yoriaki;Nojima, Yoshihisa;Matozaki, Takashi, 2010, BLOOD, 116, 18, 3517, 3525

  DOI
• Requirement of SIRP alpha for protective immunity against Leishmania major, Morimoto, Naoko;Murata, Yoji;Motegi, Sei-ichiro;Suzue, Kazutomo;Saito, Yasuyuki;Okazawa, Hideki;Ohnishi, Hiroshi;Kotani, Takenori;Kusakari, Shinya;Ishikawa, Osamu;Matozaki, Takashi, 2010, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 401, 3, 385, 389

  DOI
• Stress-Evoked Tyrosine Phosphorylation of Signal Regulatory Protein alpha Regulates Behavioral Immobility in the Forced Swim Test, Ohnishi, Hiroshi;Murata, Takaaki;Kusakari, Shinya;Hayashi, Yuriko;Takao, Keizo;Maruyama, Toshi;Ago, Yukio;Koda, Ken;Jin, Feng-Jie;Okawa, Katsuya;Oldenborg, Per-Arne;Okazawa, Hideki;Murata, Yoji;Furuya, Nobuhiko;Matsuda, Toshio;Miyakawa, Tsuyoshi;Matozaki, Takashi, 2010, JOURNAL OF NEUROSCIENCE, 30, 31, 10472, 10483

  DOI
• Promotion of Cell Spreading and Migration by Vascular Endothelial-Protein Tyrosine Phosphatase (VE-PTP) in Cooperation With Integrins, Mori, Munemasa;Murata, Yoji;Kotani, Takenori;Kusakari, Shinya;Ohnishi, Hiroshi;Saito, Yasuyuki;Okazawa, Hideki;Ishizuka, Tamotsu;Mori, Masatomo;Matozaki, Takashi, 2010, JOURNAL OF CELLULAR PHYSIOLOGY, 224, 1, 195, 204

  DOI
• Role of SIRP alpha in regulation of mucosal immunity in the intestine, Kanazawa, Yoshitake;Saito, Yasuyuki;Supriatna, Yana;Tezuka, Hiroyuki;Kotani, Takenori;Murata, Yoji;Okazawa, Hideki;Ohnishi, Hiroshi;Kinouchi, Yoshitaka;Nojima, Yoshihisa;Ohteki, Toshiaki;Shimosegawa, Tooru;Matozaki, Takashi, 2010, GENES TO CELLS, 15, 12, 1189, 1200

  DOI
• Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn, Murata, Yoji;Mori, Munemasa;Kotani, Takenori;Supriatna, Yana;Okazawa, Hideki;Kusakari, Shinya;Saito, Yasuyuki;Ohnishi, Hiroshi;Matozaki, Takashi, 2010, GENES TO CELLS, 15, 5, 513, 524

  DOI
• Expression of PTPRO in the Interneurons of Adult Mouse Olfactory Bulb, Kotani, Takenori;Murata, Yoji;Ohnishi, Hiroshi;Mori, Munemasa;Kusakari, Shinya;Saito, Yasuyuki;Kazawa, Hideki;Bixby, John L.;Matozaki, Takashi, 2010, JOURNAL OF COMPARATIVE NEUROLOGY, 518, 2, 119, 136

  DOI
• Regulation by protein tyrosine phosphorylation of stress responses in the brain, Ohnishi, Hiroshi;Kusakari, Shinya;Murata, Takaaki;Maruyama, Toshi;Hayashi, Yuriko;Takao, Keizo;Miyakawa, Tsuyoshi;Ago, Yukio;Koda, Ken;Matsuda, Toshio;Okawa, Katsuya;Saito, Yasuyuki;Murata, Yoji;Matozaki, Takashi, 2010, NEUROSCIENCE RESEARCH, 68, E58, E58

  DOI
• Regulation of the functions of dendritic cells by SIRPα, 齊藤 泰之;村田 陽二;大西 浩史, Nov. 2009, Clinical immunology & allergology, 52, 5, 494, 498
• Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation, Takashi Matozaki; Yoji Murata; Yasuyuki Saito; Hideki Okazawa; Hiroshi Ohnishi, Oct. 2009, CANCER SCIENCE, 100, 10, 1786, 1793, Scientific journal

  DOI
• 2. 脳におけるSHPS-1シグナルの解析（第56回北関東医学会総会抄録　一般演題）, 林 由里子;大西浩史;草苅 伸也;村田 陽二;齊藤 泰之;的崎 尚, Aug. 2009, The Kitakanto medical journal, 59, 3, 322, 322
• SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis, Hisanobu Sadakata; Hideki Okazawa; Takashi Sato; Yana Supriatna; Hiroshi Ohnishi; Shinya Kusakari; Yoji Murata; Tomokazu Ito; Uichi Nishiyama; Takashi Minegishi; Akihiro Harada; Takashi Matozaki, Mar. 2009, GENES TO CELLS, 14, 3, 295, 308, Scientific journal

  DOI
• Regulation of TLR signaling by phosphatases and their binding proteins, 村田 陽二;齊藤 泰之;大西 浩史, Mar. 2009, Clinical immunology & allergology, 51, 3, 232, 241
• Functions and molecular mechanisms of the CD47-SIRP alpha signalling pathway, Takashi Matozaki; Yoji Murata; Hideki Okazawa; Hiroshi Ohnish, Feb. 2009, TRENDS IN CELL BIOLOGY, 19, 2, 72, 80, Scientific journal

  DOI
• Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation, Matozaki, Takashi;Murata, Yoji;Saito, Yasuyuki;Okazawa, Hideki;Ohnishi, Hiroshi, 2009, CANCER SCIENCE, 100, 10, 1786, 1793

  DOI
• SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis, Sadakata, Hisanobu;Okazawa, Hideki;Sato, Takashi;Supriatna, Yana;Ohnishi, Hiroshi;Kusakari, Shinya;Murata, Yoji;Ito, Tomokazu;Nishiyama, Uichi;Minegishi, Takashi;Harada, Akihiro;Matozaki, Takashi, 2009, GENES TO CELLS, 14, 3, 295, 308

  DOI
• Expression of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 in Pancreatic beta-Cells and Its Role in Promotion of Insulin Secretion and Protection against Diabetes, Masaki Kobayashi; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Yuriko Hayashi; Hisae Kobayashi; Tadahiro Kitamura; Takashi Matozaki, Nov. 2008, ENDOCRINOLOGY, 149, 11, 5662, 5669, Scientific journal

  DOI
• Essential roles of SHPS-1 in induction of contact hypersensitivity of skin, Sei-Ichiro Motegi; Hideki Okazawa; Yoji Murata; Yoshitake Kanazawa; Yasuyuki Saito; Hisae Kobayashi; Hiroshi Ohnishi; Per-Arne Oldenborg; Osamu Ishikawa; Takashi Matozaki, Nov. 2008, IMMUNOLOGY LETTERS, 121, 1, 52, 60, Scientific journal

  DOI
• 15. SHPS-1による樹状細胞の機能制御（第55回北関東医学会総会抄録）, 岩村 紘子;齊藤 泰之;村田 陽二;大西 浩史;的崎 尚;金子 和光;野島 美久, Aug. 2008, The Kitakanto medical journal, 58, 3, 359, 359
• Resistance to collagen-induced arthritis in SHPS-1 mutant mice, Chie Okuzawa; Yoriaki Kaneko; Yoji Murata; Astuko Miyake; Yasuyuki Saito; Jun Okajo; Takeshi Tomizawa; Yuka Kaneko; Hideki Okazawa; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima, Jul. 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371, 3, 561, 566, Scientific journal

  DOI
• Antitumor activity of NKT cells, 村田 陽二;大西 浩史;岡澤 秀樹, Jun. 2008, Clinical immunology & allergology, 49, 6, 713, 722
• Impaired proliferation and Th1 differentiation of CD4+ T cells of SHPS-1 mutant mice, Yuka Kaneko; Yoriaki Kaneko; Hiroshi Ohnishi; Takeshi Tomizawa; Jun Okajo; Yasuyuki Saito; Chie Okuzawa; Yoji Murata; Hideki Okazawa; Yoshihisa Nojima; Koichi Okamoto; Takashi Matozaki, May 2008, Kitakanto Medical Journal, 58, 2, 133, 139, Scientific journal

  DOI
• Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system, Shinya Kusakari; Hiroshi Ohnishi; Feng-Jie Jin; Yuka Kaneko; Takaaki Murata; Yoji Murata; Hideki Okazawa; Takashi Matozaki, Apr. 2008, JOURNAL OF CELL SCIENCE, 121, 8, 1213, 1223, Scientific journal

  DOI
• Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages, Atsuko Miyake; Yoji Murata; Hideki Okazawa; Hiroshi Ikeda; Yuriko Niwayama; Hiroshi Ohnishi; Yukio Hirata; Takashi Matozaki, Feb. 2008, GENES TO CELLS, 13, 2, 209, 219, Scientific journal

  DOI
• Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47, Aki Nakaishi; Mayumi Hirose; Masato Yoshimura; Chitose Oneyama; Kazunobu Saito; Nobuharu Kuki; Makoto Matsuda; Nakayuki Honma; Hiroshi Ohnishi; Takashi Matozaki; Masato Okada; Atsushi Nakagawa, Jan. 2008, JOURNAL OF MOLECULAR BIOLOGY, 375, 3, 650, 660, Scientific journal

  DOI
• Negative regulation by SHPS-1 of Toll-like receptor-dependent proinflammatory cytokine production in macrophages, Miyake, Atsuko;Murata, Yoji;Okazawa, Hideki;Ikeda, Hiroshi;Niwayama, Yuriko;Ohnishi, Hiroshi;Hirata, Yukio;Matozaki, Takashi, 2008, GENES TO CELLS, 13, 2, 209, 219

  DOI
• Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47, Nakaishi, Aki;Hirose, Mayumi;Yoshimura, Masato;Oneyama, Chitose;Saito, Kazunobu;Kuki, Nobuharu;Matsuda, Makoto;Honma, Nakayuki;Ohnishi, Hiroshi;Matozaki, Takashi;Okada, Masato;Nakagawa, Atsushi, 2008, JOURNAL OF MOLECULAR BIOLOGY, 375, 3, 650, 660

  DOI
• Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system, Kusakari, Shinya;Ohnishi, Hiroshi;Jin, Feng-Jie;Kaneko, Yuka;Murata, Takaaki;Murata, Yoji;Okazawa, Hideki;Matozaki, Takashi, 2008, JOURNAL OF CELL SCIENCE, 121, 8, 1213, 1223

  DOI
• Resistance to collagen-induced arthritis in SHPS-1 mutant mice, Okuzawa, Chie;Kaneko, Yoriaki;Murata, Yoji;Miyake, Astuko;Saito, Yasuyuki;Okajo, Jun;Tomizawa, Takeshi;Kaneko, Yuka;Okazawa, Hideki;Ohnishi, Hiroshi;Matozaki, Takashi;Nojima, Yoshihisa, 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 371, 3, 561, 566

  DOI
• Essential roles of SHPS-1 in induction of contact hypersensitivity of skin, Motegi, Sei-Ichiro;Okazawa, Hideki;Murata, Yoji;Kanazawa, Yoshitake;Saito, Yasuyuki;Kobayashi, Hisae;Ohnishi, Hiroshi;Oldenborg, Per-Arne;Ishikawa, Osamu;Matozaki, Takashi, 2008, IMMUNOLOGY LETTERS, 121, 1, 52, 60

  DOI
• Expression of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 in Pancreatic beta-Cells and Its Role in Promotion of Insulin Secretion and Protection against Diabetes, Kobayashi, Masaki;Ohnishi, Hiroshi;Okazawa, Hideki;Murata, Yoji;Hayashi, Yuriko;Kobayashi, Hisae;Kitamura, Tadahiro;Matozaki, Takashi, 2008, ENDOCRINOLOGY, 149, 11, 5662, 5669

  DOI
• 14. CD47-SHPS-1系におけるトランスエイドサイトーシスの役割（第54回北関東医学会総会抄録 一般演題）, 草苅 伸也;大西 浩史;村田 考啓;岡澤 秀樹;村田 陽二;的崎 尚, Aug. 2007, The Kitakanto medical journal, 57, 3, 302, 302
• Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice, Takeshi Tomizawa; Yuka Kaneko; Yoriaki Kaneko; Yasuyuki Saito; Hiroshi Ohnishi; Jun Okajo; Chie Okuzawa; Tomomi Ishikawa-Sekigami; Yoji Murata; Hideki Okazawa; Koichi Okamoto; Yoshihisa Nojima; Takashi Matozaki, Jul. 2007, JOURNAL OF IMMUNOLOGY, 179, 2, 869, 877, Scientific journal

  DOI
• Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells, Jun Okajo; Yoriaki Kaneko; Yoji Murata; Takeshi Tomizawa; Chie Okuzawa; Yasuyuki Saito; Yuka Kaneko; Tomomi Ishikawa-Sekigami; Hideki Okazawa; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima, May 2007, JOURNAL OF IMMUNOLOGY, 178, 10, 6164, 6172, Scientific journal

  DOI
• Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells, Okajo, Jun;Kaneko, Yoriaki;Murata, Yoji;Tomizawa, Takeshi;Okuzawa, Chie;Saito, Yasuyuki;Kaneko, Yuka;Ishikawa-Sekigami, Tomomi;Okazawa, Hideki;Ohnishi, Hiroshi;Matozaki, Takashi;Nojima, Yoshihisa, 2007, JOURNAL OF IMMUNOLOGY, 178, 10, 6164, 6172
• Resistance to experimental autoimmune encephalomyelitis and impaired T cell priming by dendritic cells in Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 mutant mice, Tomizawa, Takeshi;Kaneko, Yuka;Kaneko, Yoriaki;Saito, Yasuyuki;Ohnishi, Hiroshi;Okajo, Jun;Okuzawa, Chie;Ishikawa-Sekigami, Tomomi;Murata, Yoji;Okazawa, Hideki;Okamoto, Koichi;Nojima, Yoshihisa;Matozaki, Takashi, 2007, JOURNAL OF IMMUNOLOGY, 179, 2, 869, 877
• CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42, Takaaki Murata; Hiroshi Ohnishi; Hideki Okazawa; Yoji Murata; Shinya Kusakari; Yuriko Hayashi; Motoaki Miyashita; Hiroshi Itoh; Per-Arne Oldenborg; Nobuhiko Furuya; Takashi Matozaki, Nov. 2006, JOURNAL OF NEUROSCIENCE, 26, 48, 12397, 12407, Scientific journal

  DOI
• Mutational analysis of the mechanism of negative regulation by Src homology 2 domwin-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages, Hiroshi Ikeda; Hideki Okazawa; Hiroshi Ohnishi; Yoji Murata; Per-Arne Oldenborg; Takashi Matozaki, Sep. 2006, JOURNAL OF IMMUNOLOGY, 177, 5, 3123, 3132, Scientific journal

  DOI
• CD47 regulation of epithelial cell spreading and migration, and its signal transduction, Masahiko Shinohara; Naoko Ohyama; Yoji Murata; Hideki Okazawa; Hiroshi Ohnishi; Osamu Ishikawa; Takashi Matozaki, Sep. 2006, CANCER SCIENCE, 97, 9, 889, 895, Scientific journal

  DOI
• Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1, T Ishikawa-Sekigami; Y Kaneko; Y Saito; Y Murata; H Okazawa; H Ohnishi; PA Oldenborg; Y Nojima; T Matozaki, May 2006, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 343, 4, 1197, 1200, Scientific journal

  DOI
• Crystallization and preliminary X-ray analysis of rat SHPS-1, A Nagata; H Ohnishi; M Yoshimura; A Ogawa; S Ujita; H Adachi; M Okada; T Matozaki; A Nakagawa, Mar. 2006, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 62, 3, 189, 191, Scientific journal

  DOI
• SHPS-1 promotes the survival of circulating erythrocytes through inhibition of phagocytosis by splenic macrophages, T Ishikawa-Sekigami; Y Kaneko; H Okazawa; T Tomizawa; J Okajo; Y Saito; C Okuzawa; M Sugawara-Yokoo; L Nishiyama; H Ohnishi; T Matozaki; Y Nojima, Jan. 2006, BLOOD, 107, 1, 341, 348, Scientific journal

  DOI
• CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42, Murata, Takaaki;Ohnishi, Hiroshi;Okazawa, Hideki;Murata, Yoji;Kusakari, Shinya;Hayashi, Yuriko;Miyashita, Motoaki;Itoh, Hiroshi;Oldenborg, Per-Arne;Furuya, Nobuhiko;Matozaki, Takashi, 2006, JOURNAL OF NEUROSCIENCE, 26, 48, 12397, 12407

  DOI
• CD47 regulation of epithelial cell spreading and migration, and its signal transduction, Shinohara, Masahiko;Ohyama, Naoko;Murata, Yoji;Okazawa, Hideki;Ohnishi, Hiroshi;Ishikawa, Osamu;Matozaki, Takashi, 2006, CANCER SCIENCE, 97, 9, 889, 895

  DOI
• Mutational analysis of the mechanism of negative regulation by Src homology 2 domwin-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages, Ikeda, Hiroshi;Okazawa, Hideki;Ohnishi, Hiroshi;Murata, Yoji;Oldenborg, Per-Arne;Matozaki, Takashi, 2006, JOURNAL OF IMMUNOLOGY, 177, 5, 3123, 3132
• Physiological Functions of a Cell-cell Signaling System, the CD47-SHPS-1 System, in Nervous System, 大西 浩史, Dec. 2005, 44, 4, 292, 300
• SHP tyrosine phosphatases and a novel cell-signaling system, T Matozaki; H Ohnishi, Oct. 2005, SEIKAGAKU, 77, 10, 1299, 1307, Scientific journal
• Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons, H Ohnishi; Y Kaneko; H Okazawa; M Miyashita; R Sato; A Hayashi; K Tada; S Nagata; M Takahashi; T Matozaki, Mar. 2005, JOURNAL OF NEUROSCIENCE, 25, 10, 2702, 2711, Scientific journal

  DOI
• Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system, H Okazawa; SI Motegi; N Ohyama; H Ohnishi; T Tomizawa; Y Kaneko; PA Oldenborg; O Ishikawa; T Matozaki, Feb. 2005, JOURNAL OF IMMUNOLOGY, 174, 4, 2004, 2011, Scientific journal

  DOI
• SHPチロシンホスファターゼと新たな細胞間シグナル伝達機構 (特集:プロテインホスファターゼ研究の最近の進歩), 的崎 尚;大西 浩史, 2005, 77, 10, 1299, 1307
• Promotion of neurite and filopodium formation by CD47: Roles of integrins, Rac, and Cdc42, M Miyashita; H Ohnishi; H Okazawa; H Tomonaga; A Hayashi; TT Fujimoto; N Furuya; T Matozaki, Aug. 2004, MOLECULAR BIOLOGY OF THE CELL, 15, 8, 3950, 3963, Scientific journal

  DOI
• (The 51th Annual Meeting of the Kitakanto Medical Society), 池田 洋;岡澤 秀樹;富澤 恭子;大西 浩史;的崎 尚, Aug. 2004, The KITAKANTO medical journal, 54, 3
• Ectodomain shedding of SHPS-1 and its role in regulation of cell migration, H Ohnishi; H Kobayashi; H Okazawa; Y Ohe; K Tomizawa; R Sato; T Matozaki, Jul. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 27, 27878, 27887, Scientific journal

  DOI
• Positive regulation of phagocytosis by SIRP beta and its signaling mechanism in macrophages, A Hayashi; H Ohnishi; H Okazawa; S Nakazawa; H Ikeda; S Motegi; N Aoki; S Kimura; M Mikuni; T Matozaki, Jul. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 28, 29450, 29460, Scientific journal

  DOI
• 新規細胞間シグナル伝達システムCD47-SHPS-1系の機能 (特集 解明が進むプロテインホスファターゼ--その新機能から疾患への関わりまで) -- (チロシンホスファターゼ), 大西 浩史;岡澤 秀樹;的崎 尚, May 2004, Cell technology., 23, 5, 546, 550
• Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis, T Koga; M Inui; K Inoue; S Kim; A Suematsu; E Kobayashi; T Iwata; H Ohnishi; T Matozaki; T Kodama; T Taniguchi; H Takayanagi; T Takai, Apr. 2004, NATURE, 428, 6984, 758, 763, Scientific journal

  DOI
• Ubiquitination-mediated regulation of biosynthesis of the adhesion receptor SHPS-1 in response to endoplasmic reticulum stress, R Murai-Takebe; T Noguchi; T Ogura; T Mikami; K Yanagi; K Inagaki; H Ohnishi; T Matozaki; M Kasuga, Mar. 2004, JOURNAL OF BIOLOGICAL CHEMISTRY, 279, 12, 11616, 11625, Scientific journal

  DOI
• Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck - Roles in regulation of T cell function, T Ito; H Okazawa; K Maruyama; K Tomizawa; S Motegi; H Ohnishi; H Kuwano; A Kosugi; T Matozaki, Sep. 2003, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 37, 34854, 34863, Scientific journal

  DOI
• Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain, Y Ohe; H Ohnishi; H Okazawa; K Tomizawa; H Kobayashi; K Okawa; T Matozaki, Sep. 2003, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 308, 4, 719, 725, Scientific journal

  DOI
• Regulation of multiple functions of SHPS-1, a transmembrane glycoprotein, by its cytoplasmic region, R Sato; H Ohnishi; H Kobayashi; D Kiuchi; A Hayashi; Y Kaneko; N Honma; H Okazawa; Y Hirata; T Matozaki, Sep. 2003, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 309, 3, 584, 590, Scientific journal

  DOI
• Role of the CD47-SHPS-1 system in regulation of cell migration, S Motegi; H Okazawa; H Ohnishi; R Sato; Y Kaneko; H Kobayashi; K Tomizawa; T Ito; N Honma; HJ Buhring; O Ishikawa; T Matozaki, Jun. 2003, EMBO JOURNAL, 22, 11, 2634, 2644, Scientific journal

  DOI
• 新しい細胞間コミュニケーションCD47-SHPS-1系, 大西 浩史, Mar. 2003, 30, 42, 42
• Nerve growth factor enhances neurotransmitter release from PC12 cells by increasing Ca2+-responsible secretory vesicles through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase., Amino S; Itakura M; Ohnishi H; Tsujimura J; Koizumi S; Takei N; Takahashi M, Jun. 2002, J. Biochem. (Tokyo), 131, 6, 887, 894, Scientific journal

  DOI
• Regulation of neurotransmitter release by tyrosine kinases, H Ohnishi, Feb. 2002, SEIKAGAKU, 74, 2, 127, 130, Scientific journal
• Regulation of neurotransmitter release by tyrosine kinases, OHNISHI Hiroshi, Feb. 2002, 74, 2, 127, 130
• Negative regulation of exocytosis at the nerve terminal, M Takahashi; H Ohnishi, 2002, MOLECULAR PSYCHIATRY, 7, 6, 536, 537, Scientific journal

  DOI
• Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules, S Yamasaki; K Nishida; M Hibi; M Sakuma; R Shiina; A Takeuchi; H Ohnishi; T Hirano; T Saito, Nov. 2001, JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 48, 45175, 45183, Scientific journal

  DOI
• A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells, H Ohnishi; S Yamamori; K Ono; K Aoyagi; S Kondo; M Takahashi, Sep. 2001, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98, 19, 10930, 10935, Scientific journal

  DOI
• BIT/SHPS-1 enhances brain-derived neurotrophic factor-promoted neuronal survival in cultured cerebral cortical neurons, T Araki; M Yamada; H Ohnishi; S Sano; H Hatanaka, Oct. 2000, JOURNAL OF NEUROCHEMISTRY, 75, 4, 1502, 1510, Scientific journal

  DOI
• Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived neurotrophic factor signaling in cultured cerebral cortical neurons, T Araki; M Yamada; H Ohnishi; S Sano; T Uetsuki; H Hatanaka, Feb. 2000, JOURNAL OF NEUROCHEMISTRY, 74, 2, 659, 668, Scientific journal

  DOI
• Gene structure of mouse BIT/SHPS-1, Shin-Ichiro Sano; Hiroshi Ohnishi; Misae Kubota, 15 Dec. 1999, Biochemical Journal, 344, 3, 667, 675, Scientific journal

  DOI
• Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons, M Yamada; H Ohnishi; S Sano; T Araki; A Nakatani; T Ikeuchi; H Hatanaka, Jul. 1999, JOURNAL OF NEUROCHEMISTRY, 73, 1, 41, 49, Scientific journal

  DOI
• Tyrosine phosphorylation and association of BIT with SHP-2 induced by neurotrophins, H Ohnishi; M Yamada; M Kubota; H Hatanaka; S Sano, Apr. 1999, JOURNAL OF NEUROCHEMISTRY, 72, 4, 1402, 1408, Scientific journal

  DOI
• Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons, M Yamada; H Ohnishi; S Sano; A Nakatani; T Ikeuchi; H Hatanaka, Nov. 1997, JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 48, 30334, 30339, Scientific journal

  DOI
• BIT, an immune antigen receptor-like molecule in the brain, S Sano; H Ohnishi; A Omori; J Hasegawa; M Kubota, Jul. 1997, FEBS LETTERS, 411, 2-3, 327, 334, Scientific journal

  DOI
• BIT (Bit) maps to mouse chromosome 2, H Ohnishi; M Kubota; S Sano, Mar. 1997, GENOMICS, 40, 3, 504, 506, Scientific journal

  DOI
• Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule, H Ohnishi; R Kubota; A Ohtake; K Sato; SI Sano, Oct. 1996, JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 41, 25569, 25574, Scientific journal

  DOI
• 脳に依存する抗原レセプター様分子の遺伝子構造とスプライシングによる多様性, 佐野 慎一郎;大西 浩史;久保田 美佐江, Aug. 1996, 19
• 1D4抗原TAMによるSHPTP2の活性化, 大西 浩史;大竹 敦子;佐藤 一紀;久保田 美佐江;佐野 慎一郎, Aug. 1996, 19
• FUNCTIONAL ROLES OF TRP(337) AND GLU(632) IN CLOSTRIDIUM GLUCOAMYLASE, AS DETERMINED BY CHEMICAL MODIFICATION, MUTAGENESIS, AND THE STOPPED-FLOW METHOD, H OHNISHI; H MATSUMOTO; H SAKAI; T OHTA, Feb. 1994, JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 5, 3503, 3510, Scientific journal
• MOLECULAR-CLONING OF A GLUCOAMYLASE GENE FROM A THERMOPHILIC CLOSTRIDIUM AND KINETICS OF THE CLONED ENZYME, H OHNISHI; H KITAMURA; T MINOWA; H SAKAI; T OHTA, Jul. 1992, EUROPEAN JOURNAL OF BIOCHEMISTRY, 207, 2, 413, 418, Scientific journal

  DOI
• PURIFICATION AND SOME PROPERTIES OF A GLUCOAMYLASE FROM CLOSTRIDIUM SP G0005, H OHNISHI; H SAKAI; T OHTA, Jul. 1991, AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 55, 7, 1901, 1902, Scientific journal

  DOI
• Corrigendum to: SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress: SHPS-1 deficiency induces robust neuroprotection (Journal of Neurochemistry, (2012), 122, 4, (834-843), 10.1111/j.1471-4159.2012.07818.x), Lang Wang; Yanyun Lu; Shan Deng; Yan Zhang; Li Yang; Yu Guan; Takashi Matozaki; Hiroshi Ohnishi; Hong Jiang; Hongliang Li, 01 Dec. 2017, Journal of Neurochemistry, 122, 4, 834, 843, Scientific journal

  DOI
• Protein-tyrosine Phosphatase Shp2 Positively Regulates Macrophage Oxidative Burst, Xing Jun Li; Charles B. Goodwin; Sarah C. Nabinger; Briana M. Richine; Zhenyun Yang; Helmut Hanenberg; Hiroshi Ohnishi; Takashi Matozaki; Gen-Sheng Feng; Rebecca J. Chan, Feb. 2015, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 7, 3894, 3909, Scientific journal

  DOI
• Shear Stress-induced Redistribution of Vascular Endothelial-Protein-tyrosine Phosphatase (VE-PTP) in Endothelial Cells and Its Role in Cell Elongation, Kemala Isnainiasih Mantilidewi; Yoji Murata; Munemasa Mori; Chihiro Otsubo; Takenori Kotani; Shinya Kusakari; Hiroshi Ohnishi; Takashi Matozaki, Mar. 2014, JOURNAL OF BIOLOGICAL CHEMISTRY, 289, 10, 6451, 6461, Scientific journal

  DOI
• SIRPα signaling regulates podocyte structure and function, Satoshi Takahashi; Mai Tomioka; Keiju Hiromura; Toru Sakairi; Hiroko Hamatani; Mitsuharu Watanabe; Hidekazu Ikeuchi; Yoriaki Kaneko; Akito Maeshima; Takeo Aoki; Hiroshi Ohnishi; Takashi Matozaki; Yoshihisa Nojima, 15 Sep. 2013, American Journal of Physiology - Renal Physiology, 305, 6, F861, F870, Scientific journal

  DOI
• Crystallization and preliminary X-ray analysis of rat SHPS-1, Aki Nagata; Hiroshi Ohnishi; Masato Yoshimura; Akira Ogawa; Sayuri Ujita; Hiroaki Adachi; Masato Okada; Takashi Matozaki; Atsushi Nakagawa, 2006, Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62, 3, 189, 191, Scientific journal

  DOI
• Anticancer efficacy of monotherapy with antibodies to SIRP alpha/SIRP beta 1 mediated by induction of antitumorigenic macrophages, Sakamoto, Mariko;Murata, Yoji;Tanaka, Daisuke;Kakuchi, Yuka;Okamoto, Takeshi;Hazama, Daisuke;Saito, Yasuyuki;Kotani, Takenori;Ohnishi, Hiroshi;Miyasaka, Masayuki;Fujisawa, Masato;Matozaki, Takashi, 04 Jan. 2022, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, 1, Scientific journal

  DOI
• ホスファターゼで解き明かす生理と病態のメカニズム　タンパク質チロシンホスファターゼを制御する細胞間相互作用シグナルの機能解析, 大西 浩史, Sep. 2020, 93回, [2S05a
• 神経細胞における低温誘導性SIRPαチロシンリン酸化メカニズムの解析, ;;;;;;;, Aug. 2020, 70, 3, 294
• ミクログリア活性化チェックポイント分子による脳老化制御, ;;;;;;;;;;, Aug. 2020, 70, 3, 294
• 成熟神経細胞特異的RAS/MAPK症候群モデル動物の表現型解析, ;;;, Aug. 2020, 70, 3, 296
• Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons., Jingu Daiki;Iino Mika;Kawasaki Joji;Urano Eriko;Kusakari Shinya;Hayashi Yuriko;Matozaki Takashi;Ohnishi Hiroshi, 10 Sep. 2021, Biochemical and Biophysical Research Communications, 569, 72, 78, Scientific journal

  DOI
• Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro., Togo Kazuyuki;Fukusumi Hayato;Shofuda Tomoko;Ohnishi Hiroshi;Yamazaki Hiroyuki;Hayashi Mariko Kato;Kawasaki Nana;Takei Nobuyuki;Nakazawa Takanobu;Saito Yumiko;Baba Kousuke;Hashimoto Hitoshi;Sekino Yuko;Shirao Tomoaki;Mochizuki Hideki;Kanemura Yonehiro, Oct. 2021, Molecular Brain, 14, 1, Scientific journal

  DOI
• Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages., Sakamoto Mariko;Murata Yoji;Tanaka Daisuke;Kakuchi Yuka;Okamoto Takeshi;Hazama Daisuke;Saito Yasuyuki;Kotani Takenori;Ohnishi Hiroshi;Miyasaka Masayuki;Fujisawa Masato;Matozaki Takashi, Proceedings of the National Academy of Sciences of the United States of America, 119, 1

  DOI
• 加齢による運動学習能低下に耐性を示すミクログリア特異的遺伝子改変マウスの解析, ;;;;;;;;;;, Aug. 2021, 71, 3, 254
• 胎仔期におけるネオニコチノイド系農薬への曝露が成熟後脳機能に与える影響の解析, ;;;;;;;;;;, Aug. 2021, 71, 3, 264
• ミクログリア活性化チェックポイントSIRPα欠損による遺伝子発現変化の解析, ;;;;;;;;;, Oct. 2023, 96回, [1P
• 造血器腫瘍および免疫性血小板減少性紫斑病における貪食チェックポイント分子SIRPαの遺伝子多型の解析(Gene polymorphism of SIRPα, a phagocytic checkpoint moleculte, in hematopoietic tumors and immune thrombocytopenic purpura), ;;;, Sep. 2023, 82回, 951
• ミクログリア活性化チェックポイントSIRPα欠損による遺伝子発現変化の解析, ;;;;;;;;;, Oct. 2023, 96回, [1P
• 造血器腫瘍および免疫性血小板減少性紫斑病における貪食チェックポイント分子SIRPαの遺伝子多型の解析(Gene polymorphism of SIRPα, a phagocytic checkpoint moleculte, in hematopoietic tumors and immune thrombocytopenic purpura), ;;;, Sep. 2023, 82回, 951

MISC

• 受容体型膜蛋白質SHPS‐1のインスリン分泌制御における機能解析, 小林雅樹; 大西浩史; 岡澤秀樹; 村田陽二; 林由里子; 北村忠弘; 的崎尚, 25 Apr. 2008, 糖尿病, 51, Supplement 1, S.123
• 受容体型膜蛋白質SHPS‐1のインスリン分泌制御における機能解析, 小林雅樹; 大西浩史; 岡澤秀樹; 村田陽二; 林由里子; 小林久江; 北村忠弘; 的崎尚, 20 Apr. 2009, 日本内分泌学会雑誌, 85, 1, 305
• An essential role of SHPS‐1 in proper development of dendritic cells for induction of Th17‐mediated autoimmune diseases, SAITO Yasuyuki; KANEKO Yoriaki; KANEKO Yuka; OKUZAWA Chie; SEKIGAMI Tomomi; OKAJO Jun; TOMIZAWA Takeshi; MURATA Yoji; OKAZAWA Hideki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 25 Oct. 2007, 日本免疫学会総会・学術集会記録, 37, 125
• Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T cell Priming by Dendritic Cells in SHPS‐1 Mutant Mice, KANEKO Yoriaki; KANEKO Yuka; TOMIZAWA Takeshi; OHNISHI Hiroshi; OKAJO Jun; OKUZAWA Chie; SAITO Yasuyuki; SEKIGAMI Tomomi; MATOZAKI Takashi; NOJIMA Yoshihisa, 25 Oct. 2007, 日本免疫学会総会・学術集会記録, 37, 269
• Promotion by VE‐PTP of lamellipodium formation in cooperation with Ras and integrin, MORI Munemasa; MURATA Yoji; OHNISHI Hiroshi; OKAZAWA Hideki; KOTANI Takenori; SAITO Yasuyuki; MORI Masatomo; MATOZAKI Takashi, 31 Aug. 2009, 日本癌学会学術総会記事, 68th, 246
• Essential roles of the CD47‐SIRP α signaling in homeostasis of lymphoid tissue dendritic cells, SAITO Yasuyuki; IWAMURA Hiroko; KANAZAWA Yoshitake; HASHIMOTO Miho; MURATA Yoji; OHNISHI Hiroshi; KANEKO Yoriaki; MATOZAKI Takashi; NOJIMA Yoshihisa, 30 Sep. 2009, 臨床血液, 50, 9, 907
• Dendritic cell‐specific depletion of protein tyrosine phosphatase Shp1 promotes Th1 differentiation causes autoimmunit, KANEKO Tetsuya; SAITO Yasuyuki; OHNISHI Hiroshi; SATO‐HASHIMOTO Miho; KOTANI Takenori; MURATA Yoji; OKAZAWA Hideki; TAKAGISHI Kenji; MATOZAKI Takashi, 07 Nov. 2011, 日本免疫学会総会・学術集会記録, 40, 199
• Tyrosine phosphorylation of SAP‐1, a receptor‐type protein tyrosine phosphatase, and its association with Grb2, MURATA Yoji; KOTANI Takenori; SUPRIATNA Yana; MORI Munemasa; OKAZAWA Hideki; OHNISHI Hiroshi; SAITO Yasuyuki; MATOZAKI Takashi, 31 Aug. 2009, 日本癌学会学術総会記事, 68th, 204
• Essential role of SIRP α on dendritic cells in organization and homeostasis of the spleen, WASHIO Ken; KOTANI Takenori; RESPATIKA Datu; MURATA Yoji; SAITO Yasuyuki; KANEKO Yoriaki; OKAZAWA Hideki; OHNISHI Hiroshi; FUKUNAGA Atsushi; NISHIGORI Chikako; MATOZAKI Takashi, 18 Nov. 2014, 日本免疫学会総会・学術集会記録, 43, Proceedings, 38
• Cell‐cell interactions via CD47‐SIRPα signal regulate microglial activation, HASHIMOTO Miho; NOZU Tomomi; URANO Eriko; SAITO Yasuyuki; KOTANI Takenori; MURATA Yoji; MATOZAKI Takashi; OHNISHI Hiroshi, 2015, 日本神経化学会大会抄録集(Web), 58th, ROMBUNNO.2P‐34 (WEB ONLY)
• Dendritic cell‐specific ablation of the protein tyrosine phosphatase Shp‐1 induces autoimmune nephritis characterized by infiltration of dendritic cell and Th1 cell, WATANABE Mitsuharu; KANEKO Yoriaki; HIROMURA Keiju; OHISHI Yuko; KINOSHITA Masato; SAITO Yasuyuki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 30 Oct. 2015, 日本免疫学会総会・学術集会記録, 44, Proceedings, 126
• Dendritic cell‐specific ablation of the protein tyrosine phosphatase Shp1 induces enhanced production of inflammatory cytokines by toll‐like receptor‐mediated stimulation, OHISHI Yuko; KANEKO Yoriaki; WATANABE Mitsuharu; KINOSHITA Masato; HIROMURA Keiju; SAITO Yasuyuki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 30 Oct. 2015, 日本免疫学会総会・学術集会記録, 44, Proceedings, 160
• Accumulation of dysregulated renal mononuclear phagocytes (rMoPh) and Th1 cells in the kidney of CD11c‐specific Shp‐1 knockout mice, WATANABE Mitsuharu; KANEKO Yoriaki; HIROMURA Keiju; KINOSHITA Masato; OHISHI Yuko; SAITO Yasuyuki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 14 Nov. 2016, 日本免疫学会総会・学術集会記録, 45, Proceedings, 180
• Shp‐1 in dendritic cells controls the development of memory‐phenotype CD8⁺ T cells, OHISHI Yuko; KANEKO Yoriaki; KINOSHITA Masato; WATANABE Mitsuharu; HIROMURA Keiju; SAITO Yasuyuki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 14 Nov. 2016, 日本免疫学会総会・学術集会記録, 45, Proceedings, 41
• 2. 脳におけるSHPS-1シグナルの解析（第56回北関東医学会総会抄録 一般演題）, 林 由里子; 大西浩史; 草苅 伸也; 村田 陽二; 齊藤 泰之; 的崎 尚, 01 Aug. 2009, 59, 3, 322, 322
• SIRPαによる脾臓T細胞の恒常性の調節, 橋本美穂; 齊藤泰之; 金子哲也; 大西浩史; 草苅伸也; 小谷武徳; 村田陽二; 岡澤秀樹; 的崎尚, 01 Aug. 2013, 北関東医学会総会プログラム・抄録, 60th, 3, 24, 25
• ミクログリアにおけるSIRPαシグナルの役割, 橋本美穂; 野津智美; 浦野江里子; 齊藤泰之; 小谷武徳; 村田陽二; 的崎尚; 大西浩史, 01 Aug. 2015, 北関東医学会総会プログラム・抄録, 62nd, 3, 20, 21
• 神経系における受容体型膜蛋白質SHPS‐1の機能解析, 草苅伸也; 大西浩史; 林由里子; 高雄啓三; 宮川剛; 齊藤泰之; 村田陽二; 的崎尚, 2009, 神経組織の成長・再生・移植研究会学術集会プログラム・予稿集, 24th, 64
• 脳におけるSHPS‐1シグナルの解析, 林由里子; 大西浩史; 草苅伸也; 村田陽二; 齊藤泰之; 的崎尚, 2009, 北関東医学会総会プログラム・抄録, 56th, 14
• シグナル伝達研究 II:現象から因子へ 6.CD47‐SHPS‐1系による樹状細胞の機能制御, 齊藤泰之; 村田陽二; 大西浩史; 的崎尚, 15 Sep. 2008, 実験医学, 26, 15, 2424, 2431
• VE‐PTPによるRas,インテグリン依存的なラメリポディア形成の促進, 森宗昌; 村田陽二; 大西浩史; 岡澤秀樹; 齊藤泰之; 森昌朋; 的崎尚, 25 Sep. 2009, 生化学, ROMBUNNO.4T5A-18
• 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP‐1とIL‐10による炎症性腸疾患の制御, 小谷武徳; 村田陽二; YANA Supriatna; 大西浩史; 定方久延; 草苅伸也; 齊藤泰之; 岡澤秀樹; 的崎尚, 25 Sep. 2009, 生化学, ROMBUNNO.4T5A-16
• 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP‐1とIL‐10による炎症性腸疾患の制御, 小谷武徳; 村田陽二; YANA Supriatna; 岡澤秀樹; 大西浩史; EDWIN Daniwijaya; 定方久延; 草苅伸也; 齊藤泰之; 大川克也; 的崎尚, 2010, 生化学, ROMBUNNO.4P-0447
• 血管内皮細胞のシェアストレス刺激応答におけるVE‐PTPの機能解析, 村田陽二; 森宗昌; 小谷武徳; 草苅伸也; 岡澤秀樹; 齊藤泰之; 大西浩史; 的崎尚, 2010, 生化学, ROMBUNNO.4T9-2
• 脳におけるSIRPαチロシンリン酸化の解析, 丸山登士; 大西浩史; 草苅伸也; 林由里子; 村田陽二; 齊藤泰之; 岸章治; 的崎尚, 01 Aug. 2010, Kitakanto Medical Journal, 60, 3, 302, 303
• 低温ストレスによるSIRPαチロシンリン酸化の誘導, 丸山登士; 大西浩史; 草苅伸也; 林由里子; 草苅百合子; 村田陽二; 齊藤泰之; 岸章治; 的崎尚, 2010, 生化学, ROMBUNNO.4P-0434
• 脾臓T細胞の恒常性調節へのSIRPαの関与, 橋本(佐藤)美穂; 齊藤泰之; 金子哲也; 大西浩史; 草苅伸也; 小谷武徳; 村田陽二; 岡澤秀樹; 的崎尚, 2012, 日本生化学会大会(Web), 85th, 3T29-06 (WEB ONLY)
• 樹状細胞のチロシンホスファターゼSHP‐1は自己免疫疾患発症に関与する, 金子哲也; 齊藤泰之; 大西浩史; 岡邨興一; 米本由木夫; 篠崎哲也; 的崎尚; 高岸憲二, 25 Aug. 2011, 日本整形外科学会雑誌, 85, 8, S1299
• SIRPα欠損マウスにおけるクプリゾン感受性の亢進, 野津智美; 橋本美穂; ELHANBALY Ruwaida; 石川達也; 齊藤泰之; 小谷武徳; 村田陽二; 深澤有吾; 的崎尚; 大西浩史, 2016, 北関東医学会総会プログラム・抄録, 63rd, 27‐28
• 腸粘膜上皮細胞の微絨毛に局在する受容体型チロシンホスファターゼSAP‐1とCEACAM20による腸管免疫制御, 村田陽二; 小谷武徳; YANA Supriatna; 北村泰明; 今田慎也; 齊藤泰之; 大西浩史; 的崎尚, 05 Jun. 2015, 日本細胞生物学会大会要旨集, 67th, 175
• 白質におけるミクログリア恒常性制御, 野津智美; 橋本美穂; ELHANBALY Ruwaida; 石川達也; 齊藤泰之; 小谷武徳; 村田陽二; 深澤有吾; 的崎尚; 大西浩史, 2016, 日本生物学的精神医学会(Web), 38th, 149 (WEB ONLY)
• 細胞間シグナルCD47‐SIRPα系の生理機能とその臨床応用, 的崎尚; 村田陽二; 齊藤泰之; 小谷武徳; 柳田匡彦; 田中大介; 大西浩史, 2016, 日本生化学会大会(Web), 89th, ROMBUNNO.1S10‐6 (WEB ONLY)
• がん‐マクロファージ間相互作用を標的とした新規がん免疫療法の開発, 村田陽二; 柳田匡彦; 田中大介; 羽間大祐; 齊藤泰之; 小谷武徳; 大西浩史; 的崎尚, 2017, 日本生化学会大会(Web), 90th, ROMBUNNO.3AT26‐02(3P‐0901) (WEB ONLY)
• 樹状細胞特異的Shp1欠損マウスにおける自己免疫性腎炎の解析, 渡辺 光治; 廣村 桂樹; 金子 和光; 大石 裕子; 木下 雅人; 坂入 徹; 池内 秀和; 前嶋 明人; 大西 浩史; 的崎 尚; 野島 美久, Apr. 2015, 日本腎臓学会誌, 57, 3, 486, 486
• 樹状細胞特異的Shp1欠損マウスにおける自己免疫性腎炎の解析(第2報), 渡辺 光治; 廣村 桂樹; 金子 和光; 木下 雅人; 大石 裕子; 坂入 徹; 池内 秀和; 前嶋 明人; 大西 浩史; 的崎 尚; 野島 美久, May 2016, 日本腎臓学会誌, 58, 3, 278, 278
• がん原遺伝子BRAFの機能獲得性変異は先天性異常を引き起こす, 井上 晋一; 守谷 充司; 宮川 幸子; 田; 中嶌 八隅; 大場 大樹; 新堀 哲也; 橋 美里; 大西 浩史; 呉 繁夫; 松原 洋一; 青木 洋子, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2LBA092], [2LBA092]
• 脳に依存する抗原レセプター様分子の遺伝子構造とスプライシングによる多様性, 佐野慎一郎; 大西浩史; 久保田美佐江, 01 Aug. 1996, 19
• SIRPαによる樹状細胞の機能制御 (特集 樹状細胞の機能と関与分子), 齊藤泰之; 村田陽二; 大西浩史, Nov. 2009, 52, 5, 494, 498
• TLRシグナルのホスファターゼおよびその会合分子による制御 (特集 TLRシグナルの制御), 村田陽二; 齊藤泰之; 大西浩史, Mar. 2009, 51, 3, 232, 241
• 15.SHPS-1による樹状細胞の機能制御(一般演題,第55回北関東医学会総会抄録), 岩村紘子; 齊藤泰之; 村田陽二; 大西浩史; 的崎尚; 金子和光; 野島美久, 01 Aug. 2008, 58, 3
• NKT細胞の抗腫瘍作用, 村田陽二; 大西浩史; 岡澤秀樹, Jun. 2008, 49, 6, 713, 722
• 14. CD47-SHPS-1系におけるトランスエンドサイトーシスの役割(一般演題,第54回北関東医学会総会抄録), 草苅伸也; 大西浩史; 村田考啓; 岡澤秀樹; 村田陽二; 的崎尚, 01 Aug. 2007, 57, 3
• 細胞間シグナル伝達システムCD47-SHPS-1系の神経系における機能, 大西浩史, Dec. 2005, 44, 4, 292, 300
• SHPチロシンホスファターゼと新たな細胞間シグナル伝達機構 (特集:プロテインホスファターゼ研究の最近の進歩), 的崎尚; 大西浩史, 2005, 77, 10, 1299, 1307
• 16. 変異型SHPS-1のマクロファージ貪食に対する効果(一般演題)(第51回北関東医学会総会抄録), 池田洋; 岡澤秀樹; 富澤恭子; 大西浩史; 的崎尚, 01 Aug. 2004, 54, 3
• 新規細胞間シグナル伝達システムCD47-SHPS-1系の機能 (特集 解明が進むプロテインホスファターゼ--その新機能から疾患への関わりまで) -- (チロシンホスファターゼ), 大西浩史; 岡澤秀樹; 的崎尚, May 2004, 23, 5, 546, 550
• チロシンキナーゼによる神経伝達物質放出の制御, 大西浩史, 25 Feb. 2002, 74, 2, 127, 130
• 1D4抗原TAMによるSHPTP2の活性化, 大西浩史; 大竹敦子; 佐藤一紀; 久保田美佐江; 佐野慎一郎, 01 Aug. 1996, 19
• SIRP alpha(+) dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen, Yasuyuki Saito; Satomi Komori; Datu Respatika; Ken Washio; Takenori Kotani; Yoji Murata; Hiroshi Ohnishi; Katsuyuki Yui; Koji Yasutomo; Takashi Matozaki, Dec. 2017, CYTOKINE, 100, 55, 55, Summary international conference
• SHPS- 1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative (vol 122, pg 834, 2012), L. Wang; Y. Lu; S. Deng; Y. Zhang; L. Yang; Y. Guan; T. Matozaki; H. Ohnishi; H. Jiang; H. Li, Dec. 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 761, 761, Others

  DOI
• The CD47-SIRP alpha signalling system: its physiological roles and therapeutic application, Yoji Murata; Takenori Kotani; Hiroshi Ohnishi; Takashi Matozaki, Jun. 2014, JOURNAL OF BIOCHEMISTRY, 155, 6, 335, 344, Book review

  DOI
• Hypothermia-induced tyrosine phosphorylation of SIRP alpha in the brain, S. Kusakari; T. Maruyama; M. Sato-Hashimoto; Y. Hayashi; Y. Kusakari; T. Kotani; Y. Murata; S. Kishi; T. Matozaki; H. Ohnishi, Oct. 2012, JOURNAL OF NEUROCHEMISTRY, 123, 67, 67, Summary international conference
• IMPORTANCE OF THE PROTEIN TYROSINE PHOSPHATASE SHP1 IN DENDRITIC CELLS FOR PREVENTION OF TH1 CELL DIFFERENTIATION AND AUTOIMMUNITY: A POTENTIAL TARGET FOR THE THERAPY, T. Kaneko; Y. Saito; T. Kotani; H. Ohnishi; Y. Murata; Y. Yonemoto; K. Okamura; T. Matozaki; K. Takagishi, Jun. 2012, ANNALS OF THE RHEUMATIC DISEASES, 71, 73, 73, Summary international conference
• Regulation by protein tyrosine phosphorylation of depression-like behavior, Hiroshi Ohnishi; Takashi Matozaki, 2011, NEUROSCIENCE RESEARCH, 71, E36, E36, Summary international conference

  DOI
• Regulation by protein tyrosine phosphorylation of stress responses in the brain, Hiroshi Ohnishi; Shinya Kusakari; Takaaki Murata; Toshi Maruyama; Yuriko Hayashi; Keizo Takao; Tsuyoshi Miyakawa; Yukio Ago; Ken Koda; Toshio Matsuda; Katsuya Okawa; Yasuyuki Saito; Yoji Murata; Takashi Matozaki, 2010, NEUROSCIENCE RESEARCH, 68, E58, E58, Summary international conference

  DOI
• Regulation by CD47 of epithelial cell spreading and migration and its signal transduction, M. Shinohara; N. Ohyama; Y. Murata; H. Okazawa; H. Ohnishi; T. Matozaki, Aug. 2006, REGULATORY PEPTIDES, 135, 3, 158, 159, Summary international conference
• A novel intercellular communication system, the CD47-SHPS-1 system, in neuronal network, H Ohnishi; M Miyashita; T Murata; Y Kaneko; H Okazawa; T Matozaki, Aug. 2005, JOURNAL OF NEUROCHEMISTRY, 94, 84, 84, Summary international conference
• A novel cell-cell communication system, which acts through tyrosine phosphatase SHP-2: Its function in the central nervous system, H Ohnishi; T Matozaki, 2004, JOURNAL OF PHARMACOLOGICAL SCIENCES, 94, 14P, 14P, Summary international conference
• Inhibition of neurotransmitter release by protein-tyrosine kinase, H Ohnishi; S Yamamori; K Hirata; K Aoyagi; S Kondo; M Takahashi, Sep. 2001, JOURNAL OF NEUROCHEMISTRY, 78, 199, 199, Summary international conference
• Phosphatidylinositol 3-kinase play a critical role in growth factor-induced enhancement of neurotransmitter release, M Itakura; H Ohnishi; S Amino; M Sekiguchi; R Kuwahara; S Yamamori; M Kataoka; M Takahashi, Sep. 2001, JOURNAL OF NEUROCHEMISTRY, 78, 199, 199, Summary international conference

Books etc

• 臨床薬理の進歩, Single work, 2004
• ブレインサイエンス・レビュー, 2005
• タンパク質科学イラストレイテッド, 2005
• ストライヤー 基礎生化学, 2010
• ストライヤー 生化学, 2013
• 実験医学増刊 シグナル伝達研究2008-'09 疾患発症の分子メカニズムと実現化する分子標的薬開発, 2008, ISBN: 9784758102933

Presentations

• SENESCENCE-LIKE ACTIVATION OF ASTROCYTES IN THE BRIN OF MICROGLIA-SPECIFIC SIRPα DEFICIENT MICE, Etsumi Oike, Shunya Hanzawa, Yuka Moriya, Eriko Urano, Eiko Matsumoto, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi, FASEB Science Research Conferences Protein Phosphatases, 09 Dec. 2024, 08 Dec. 2024, 12 Dec. 2024, English, Palm Springs, California, USA, United States, International conference
• Area-specific emergence of CD11c-positive microglia in the brain of SIRPα knockout mice, Etsumi Oike, Rui Mizutani, Shunya Hanzawa, Eriko Urano, Eiko Matsumoto, Yuriko Hayashi, Hiroshi Ohnishi, The 5th Japan-Taiwan Bilateral Conference on Protein Phosphatase, 23 Mar. 2024, 23 Mar. 2024, 24 Mar. 2024, Japan
• Behavioral analysis of age-related changes in coordinated motor learning ability in mice using spontaneous running wheel test, 本澤拓郎，尾池恵摘，榛澤春哉，守家優佳，松本映子，浦野江里子，林由里子，大西浩史, 第47回日本分子生物学会年会, 29 Nov. 2024, 27 Nov. 2024, 29 Nov. 2024, Japanese, Japan
• ダイバーシティ推進委員会企画ランチョンワークショップ, 多胡　めぐみ（慶應大学） 大西　浩史（群馬大学） 照沼　美穂（新潟大学） 山内　淳司（東京薬科大学） 山崎 和彦 (産業技術総合研究所), 第97回日本生化学会大会, 07 Nov. 2024, 06 Nov. 2024, 08 Nov. 2024, Japanese, Japan
• Regulation of astrocyte activation by microglial SIRPα, 尾池恵摘，榛澤春哉，守家優佳，雨宮咲久良，松本映子，浦野江里子，林由里子，的崎尚，大西浩史, 第97回日本生化学会大会, 06 Nov. 2024, 06 Nov. 2024, 08 Nov. 2024, Japanese, Japan
• ミクログリア活性化チェックポイント SIRPα欠損による遺伝子発現変化の解析, 榛澤春哉, 水谷瑠依, 尾池恵摘, 今井武史, 浦野江里子, 松本映子, 神宮大輝, 林由里子, 的崎尚, 大西浩史, 第96回日本生化学会大会, 31 Oct. 2023, 31 Oct. 2023, 02 Nov. 2023, Japan
• SIRPa欠損によるCDlle陽性ミクログリア出現領域の解析, 尾池恵摘、水谷瑠依、榛澤春哉、今井武史、浦野江里子、松本映子、林由里子、大西浩史, 第70回北関東医学会, 28 Sep. 2023, 28 Sep. 2023, 29 Sep. 2023, Japan
• SIRPα 欠損ミクログリアの遺伝子発現プロファイル解析, 榛澤春哉、水谷瑠依、尾池恵摘、今井武史、浦野江里子、松本映子、林由里子、大西浩史, 第70回北関東医学会, 28 Sep. 2023, 28 Sep. 2023, 29 Sep. 2023, Japan
• 膜型分子SIRPαによる保護的ミクログリア活性化制御, 水谷瑠依、尾池恵摘、榛澤春哉、今井武史、浦野江里子、松本映子、林由里子、大西浩史, 第70回北関東医学会, 28 Sep. 2023, 28 Sep. 2023, 29 Sep. 2023, Maebashi, Japan, Domestic conference
• Gene polymorphism of SIRPα, a phagocytic checkpoint molecule, in hematopoietic tumors and immune thrombocytopenic purpura., 堀鮎香、後藤七海、齋藤貴之、大西浩史, 第82回日本癌学会学術総会, 22 Sep. 2023, 21 Sep. 2023, 23 Sep. 2023
• 造血器腫瘍と自己免疫疾患における貪食チェックポイント遺伝子多 型の解析, 堀 鮎香、後藤七海、齋藤貴之、大西浩史, 第21回生体機能研究会, 02 Sep. 2023, 01 Sep. 2023, 02 Sep. 2023
• Analysis of characteristics of SIRPα-deficient microglia with potential brain protective effects, 水谷 瑠依、尾池恵摘、榛澤春哉、今井 武史、富山飛鳥、浦野江里子、松本映子、林 由里子、的崎 尚、大西 浩史, 第64回日本神経病理学会総会学術研究会 第66回日本神経化学会大会 合同大会, 07 Jul. 2023, 06 Jul. 2023, 08 Jul. 2023, English
• Region-specificity of the emergence of CD11c+ microglia due to lack of the phagocytic checkpoint molecule SIRPα, 尾池恵摘、水谷瑠依、今井武史、榛澤春哉、堀鮎香、浦野江里子、松本映子、神宮大輝、林由里子、的崎尚、大西浩史, 第64回日本神経病理学会総会学術研究会 第66回日本神経化学会大会 合同大会, 07 Jul. 2023, 06 Jul. 2023, 08 Jul. 2023, English
• 膜型分子SIRPαによるミクログリア活性化制御, Rui Mizutani, Etsumi Oike, Takeshi Imai, Daichi Masabayashi, Shunya Hanzawa, Eriko Urano, Daiki Jingu, Yuriko Hayashi, Hiroshi Ohnishi, 69th Kitakanto Igaku Kai Soukai, 29 Sep. 2022, 29 Sep. 2022, 30 Sep. 2022, Japanese
• SIRPα欠損マウスにおける脳内ミクログリア活性化領域の解析, Etsumi Oike, Rui Mizutani, Takeshi Imai, Haruko Imada, Daichi Masabayashi, Shunya Hanzawa, Eriko Urano, Daiki Jingu, Yuriko Hayashi, Hiroshi Ohnishi, 69th Kitakanto Igaku Kai Soukai, 29 Sep. 2022, 29 Sep. 2022, 30 Sep. 2022, Japanese, Domestic conference
• SIRPαコンディショナルKOマウスにおけるCre発現に伴うCx3cr1遺伝子ヘテロ欠損の影響の解析, Takeshi Imai, Rui Mizutani, Etsumi Oike, Asuka Tomiyama, Syunya Hanzawa, Daichi Masabayashi, Haruko Imada, Eriko Urano, Daiki Jingu, Yuriko Hayashi, Hiroshi Ohnishi, 69th Kitakanto Igaku Kai Soukai, 29 Sep. 2022, 29 Sep. 2022, 30 Sep. 2022, Japanese
• 貪食抑制受容体SIRPαの遺伝子多型と造血器腫瘍病態との関連解析, Ayuka Hori, Nanami Goto, Takayuki Saito, Hiroshi Ohnishi, 69th Kitakanto Igaku Kai Soukai, 29 Sep. 2022, 29 Sep. 2022, 30 Sep. 2022, Japanese, Maebashi, Japan, Domestic conference
• CD47-SIRPα signal as a check point of microglia activation in the brain., Hiroshi Ohnishi, The Protein Phosphatases Conference 2022 (FASEB meeting), 15 Dec. 2022, 11 Dec. 2022, 15 Dec. 2022, English, Palm Springs, CA, USA, United States, International conference
• ミクログリアにおけるCX3CR1とSIRPαの機能的相互作用, Takeshi Imai, Asuka Tomiyama, Rui Mizutani, Sayoko Matsushita, Ayako Morita, Eriko Urano, Daiki Jingu, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi, Neuro2022, 01 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022, English, Okinawa, Japan
• 加齢による運動学習能低下が改善するミクログリア特異的SIRPα欠損マウスにおける遺伝子発現解析, Rui Mizutani, Asuka Tomiyama, Takeshi Imai, Saeko Matsushita, Ayako Morita, Eriko Urano, Miho Sato-Hashimoto, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi, Neuro2022, 01 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022, English, Okinawa, Japan, Domestic conference
• 胎仔期のネオニコチノイド暴露が成熟後のマウス脳機能に与える影響, Hiroshi Ohnishi, Akira Moriya, Shuhei Otani, Danieru Gon, Ayako Morita, Eriko Urano, Miho Sato-Hashimoto, Tsuneo Sekijima, Neuro2022, 02 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022, English, Okinawa, Japan, Domestic conference
• 成熟前脳神経細胞特異的CFC症候群モデルマウスの解析, Akira Moriya, Shin-ichi Inoue, Fumihito Saitow, Yoko Aoki, Hiroshi Ohnishi, Neuro2022, 03 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022, English, Okinawa, Domestic conference
• 脳白質におけるSIRPα欠損ミクログリア活性化の領域特異性解析, Etsumi Oike, Rui Mizutani, Takeshi Imai, Haruko Imada, Shunya Hanzawa, Daichi Masabayashi, Daiki Jingu, Yuriko Hayashi, Takashi Matozaki, Hiroshi Ohnishi, 第95回日本生化学会大会 波及する生化学〜生命科学の革新へ〜, 09 Nov. 2022, 09 Nov. 2022, 11 Nov. 2022, Japanese, Nagoya, Japan, Domestic conference
• 造血器腫瘍における貪食チェックポイント分子SIRPαの遺伝子多型の解析, Ayuka Hori, Nanami Gotoh, Takayuki Saito, Hiroshi Ohnishi, 第95回日本生化学会大会 波及する生化学〜生命科学の革新へ〜, 10 Nov. 2022, 09 Nov. 2022, 11 Nov. 2022, Japanese, Nagoya, Japan, Domestic conference
• Inhibitory effect of ethacrynic acid to low temperature-induced tyrosine phosphorylatio of SIRPα, Joji Kawasaki, Yumi Watanabe, Daiki Jingu, Mika Iino, Ayaka Motai, Taiki Kono, Eriko Urano, Hiroshi Ohnishi, The 14th International Conference on Protein Phosphatase, 10 Dec. 2020, 10 Dec. 2020, 12 Dec. 2020, English, Sysmex Hall in Kobe Univ Grad School of Med, Shinryoku Hall in Kobe Univ Grad School of Med, International conference
• Lack of the check point signal for microglial activation improves age-related motor learining deficits, Asuka Tomiyama, Daisuke Yokota, Takeshi Imai, Joji Kawasaki, Akira Moriya, Mika Iino, Ayako Morita, Eriko Urano, Yuriko Hayashi, Miho Hashimoto, Hiroshi Ohnishi, The 14th International Conference on Protein Phosphatase, 10 Dec. 2020, 10 Dec. 2020, 12 Dec. 2020, English, Sysmex Hall in Kobe Univ Grad School of Med, Shinryoku Hall in Kobe Univ Grad School of Med, International conference
• 成熟神経細胞特異的RAS/MAPK症候群モデル動物の表現型解析, 森谷晃、井上晋一、青木洋子、大西浩史, 第67回北関東医学会, 24 Sep. 2020, 24 Sep. 2020, 25 Sep. 2020
• ミクログリア活性化チェックポイント分子による脳老化制御, 富山飛鳥、横田大輔、今井武史、川﨑穣二、森谷晃、飯野美香、森田紋子、浦野江里子、林由里子、橋本美穂、大西浩史, 第67回北関東医学会, 24 Sep. 2020, 24 Sep. 2020, 25 Sep. 2020
• 神経細胞における低温誘導性SIRPαチロシンリン酸化メカニズムの解析, 川﨑穣二、渡辺佑美、神宮大輝、飯野美香、茂田井彩香、河野大希、浦野江里子、大西浩史, 第67回北関東医学会, 24 Sep. 2020, 24 Sep. 2020, 25 Sep. 2020
• 貪食チェックポイント分子によるミクログリア活性化と脳老化の制御, 富山飛鳥、今井武史、横田大輔、川﨑穣二、森谷晃、飯野美香、森田紋子、浦野江里子、林由里子、橋本美穂、大西浩史, 第19回生体機能研究会, 17 Sep. 2020, 17 Sep. 2020, 18 Sep. 2020
• タンパク質チロシンホスファターゼを制御する細胞間相互作用シグナルの機能解析, 大西浩史, 第93回日本生化学会大会, 15 Sep. 2020, 14 Sep. 2020, 16 Sep. 2020, English
• A check-point molecule that controls activation phase of microglia, Hiroshi Ohnishi, Yuriko Hayashi, Miho Sato-Hashimoto, Daisuke Yokota, Ayuto Shimoda, Hiromi Nagai, Riho Toriba, Ayano Horikoshi, Miho Akaike, Hiroshi Ohnishi, The10th International Society of Radiation Neurobiology Conference, 13 Mar. 2019, 13 Mar. 2019, 14 Mar. 2019, English, International conference
• Induction of long-term torpor by enhancing the adenosine receptor signal via PPARs activation, Miho Sato-Hashimoto; Hiroshi Ohnishi, 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies in conjunction with The 96th Annual Meeting of the Physiological Society of Japan, 28 Mar. 2019, English, Kobe Convention Center, International conference
• SIRPαシグナルの欠損がミクログリアに与える影響, 橋本美穂; 堀越絢乃; 永井裕美; 神宮大輝; 赤池美穂; 浦野江里子; 的崎尚; 大西浩史, 第16回生体機能研究会, 22 Sep. 2017, Japanese, 岐阜大学サテライトキャンパス 岐阜スカイウィング37東棟4階, Domestic conference
• 新しい細胞間シグナル伝達システムCD47-SHPS-1系と細胞機能, 生体調節研究所シンポジウム”脂質メディエーターの動態と生体機能”, 2002
• Role of the CD47-SHPS-1 System in Regulation of Cell Migration, 第１回 文部科学省特定領域「がん」6領域若手研究者ワークショップ, 2002
• 新しい細胞間シグナル伝達システムCD47-SHPS-1系の生理機能, 第１回 生体機能研究会, 2002
• CD47 promote neurite extension and filopodium formation through activation of Rac and Cdc42, 群馬大学 国際シンポジウム Molecular Mechanisms of Vesicle Trafficking and Membrane Fusion, 2003
• 新しい細胞間シグナル伝達系CD47-SHPS-1系による細胞運動の制御, 21世紀COEプログラム「生体情報の受容伝達と機能発現」平成14年度研究成果報告会, 2003
• Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain, 第７６回日本生化学会大会, 2003
• Ectodomain shedding of SHPS-1 and its functional roles., 第７６回日本生化学会大会, 2003
• 上皮細胞におけるCD47の局在とその機能, 第７７回 日本生化学会大会, 2004
• Regulation of the binding ability of SHPS-1 to its ligand CD47 by the cytoplasmic tail of SHPS-1, 第７６回 日本生化学会大会, 2003
• Polarized localization of SHPS-1 and its ligand in hippocampal neurons, 第７６回 日本生化学会大会, 2003
• Physiological roles of the CD47-SHPS-1 system, 第７６回 日本生化学会大会, 2003
• 新しい細胞間シグナル伝達システムCD47-SHPS-1系によるがん細胞浸潤の制御, 日本癌学会第62回総会, 2003
• Polarized localization of SHPS-1 and its ligand CD47 in hippocampal neurons, 第４６回 日本神経化学会大会, 2003
• The Molecular Mechanism for Negative Regulation by SHPS-1 of Phagocytosis by Macrophages, 第４回 文部科学省特定領域「がん」6領域若手研究者ワークショップ, 2003
• 新しい細胞間シグナル伝達システムCD47-SHPS-1系による細胞運動の制御, 第１回 日本プロテインホスファターゼ研究会学術集会, 2003
• SHPS-1によるマクロファージ機能のCD47依存的および非依存的制御, 第１回 日本プロテインホスファターゼ研究会学術集会, 2003
• 中枢神経系における新しいシグナリングシステムCD47-SHPS-1系の機能, 第２回 生体機能研究会, 2003
• 脳における新しい細胞間シグナリングシステムCD47-SHPS-1系の機能, 平成１５年生理学研究所研究会「神経可塑性の分子的基盤」, 2003
• A Novel Intercellular Communication System, The CD47-SHPS-1 System, in Neuronal Network, Hiroshi Ohnishi, ISN-ESN: 20th Biennial Meeting International Society for Neurochemistry jointly with the European Society for Neurochemistry, 2005, English, Innsbruck, Austria, International conference
• マクロファージ貪食制御におけるSHPS-1とそのファミリー分子SIRPβの役割, 第７８回日本生化学会大会, 2005
• Roles of CD47 in regulation of cell-cell adhesion and cell migration in epithelial cells, 第五回 文部科学省特定領域研究「がん」６領域 若手研究者ワークショップ, 2004
• Positive regulation of phagocytosis by SIRPbeta and Its signaling mechanism in macrophage, Gordon Research Conference on Signaling by Adhesion Receptors, 2004
• The role of SHPS-1 in the negative regulation of macrophage phagocytosis, Gordon Research Conference on Signaling by Adhesion Receptors, 2004
• チロシンホスファターゼSHP-2 を介して作用する新たな細胞間シグナル伝達機構とその神経系における機能, 第７７回 日本薬理学会年会, 2004
• Physiological roles of the CD47-SHPS-1 system, a novel intercellular communication system, and its implication in cancer cell invasion, The 8th Korea-Japan Cancer Research Workshop, 2003, English, Naha, International conference
• Role of the CD47-SHPS-1 System in Regulation of Cell Migration, The American Society for Cell Biology 43rd Annual Meeting, 2003
• SIRPβによるマクロファージの貪食制御とそのシグナル伝達経路, 第２６回 日本分子生物学会年会, 2003
• Positive regulation by SIRPbeta of macrophage phagocytosis and its signal transduction, 群馬大学 国際シンポジウム Molecular Mechanisms of Vesicle Trafficking and Membrane Fusion, 2003
• CD47による神経突起伸長の制御とその分子機構, 第２６回 日本分子生物学会年会, 2003
• CD47-SHPS-1系によるマクロファージ貪食の負の制御, 第２回日本プロテインホスファターゼ研究会, 2005
• 細胞間シグナル伝達システムCD47-SHPS-1系の神経系における機能解析, 第２回日本プロテインホスファターゼ研究会, 2005
• CD47-SHPS-1系の生理機能：CD47の機能を中心に, 第４回生体機能研究会, 2005
• The CD47-SHPS-1 system: A novel intercellular communication system in the formation of neuronal networks, キーストンシンポジウム, 2005
• 細胞間シグナルシステムCD47-SHPS-1系の神経系における機能解析, 第７７回 日本生化学会大会, 2004
• CD47-SHPS-1系によるマクロファージ貪食制御, 第７７回 日本生化学会大会, 2004
• SHPS-1を介したマクロファージ貪食制御の分子機構, 第５１回北関東医学会総会, 2004
• 新規細胞間シグナルシステムCD47-SHPS-1系の神経系における機能, 第２７回日本神経科学大会・第４７回日本神経化学会大会 合同大会 (Neuro2004), 2004
• 細胞間シグナルシステムCD47-SHPS-1系の神経回路形成への関与, 21世紀COEプログラム「生体情報の受容伝達と機能発現」平成16年度研究成果報告会, 2005
• 新規細胞間シグナル伝達機構CD47-SHPS-1系の神経系における機能解析, 21世紀ＣＯＥプログラム「生体情報の受容伝達と機能発現」平成15年度報告会, 2004
• 細胞間相互作用シグナルによる神経回路網の制御−新規細胞間シグナル伝達システムCD47-SHPS-1系−, 第２回名古屋大学環境医学研究所・群馬大学生体調節研究所合同シンポジウム, 2005
• CD47-SHPS-1系による細胞運動と接着の制御機構, 第２８回日本分子生物学会年会, 2005
• 極性をもった細胞間相互作用システムCD47-SHPS-1系による神経突起形成制御, 第２８回日本分子生物学会年会, 2005
• SHPS-1を介したCD47のトランスエンドサイトーシスとその分子メカニズム, 第７８回日本生化学会大会, 2005
• CD47による上皮細胞の接着と運動の制御, 第７８回日本生化学会大会, 2005
• 新規細胞間シグナルシステムCD47-SHPS-1系の神経系における機能解析, 第４８回日本神経化学会大会, 2005
• 上皮細胞におけるCD47による細胞の接着と運動の制御, 第64回日本癌学会学術総会, 2005
• CD47-SHPS-1系によるマクロファージ貪食の制御, 第64回日本癌学会学術総会, 2005
• SHPS-1のEctodomain Sheddingとその細胞運動制御における役割, 第64回日本癌学会学術総会, 2005
• SHPS-1-mediated transendocytosis of CD47 and its molecular mechanism., COE国際シンポジウム「細胞内小胞輸送 −分子機構から疾患まで−」Molecular Physiology and Pathology of Membrane Traffic, 2006
• CD47-SHPS-1系による神経突起形成の制御機構, 平成18年度 生理学研究所シナプス研究会 「シナプス形成と可塑性機構獲得の統合的理解へ向けた学際的アプローチ」, 2006
• NKT細胞の活性化と癌転移抑制におけるSHPS-1の役割, 第６５回日本癌学会学術総会, 2006
• CD47 promotes neuronal development through Src-and FRG/Vav2-mediated activation of Rac and Cdc42, 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, 2006
• SHPS-1によるマクロファージ貪食抑制の分子機構：変異型SHPS-1を用いた検討, 第６５回日本癌学会学術総会, 2006
• Regulation by CD47 of epithelial cell spreading and migration and its signal transduction, 第16回生理活性ペプチド国際シンポジウム, 2006
• CD47のトランスエンドサイトーシス制御機構, 第５回生体機能研究会, 2006
• 神経系におけるCD47-SHPS-1系の機能解析, 第５回生体機能研究会, 2006
• マクロファージにおけるSHPS-1によるToll-like receptorを介したサイトカイン産生の制御, 第6回生体機能研究会, 2007
• 細胞間シグナルシステムCD47-SHPS-1系による神経突起形成の制御, Neuro2007 第30回日本神経科学大会 第50回日本神経化学会大会 第17回日本神経回路学会大会 合同大会, 2007
• 細胞間シグナル伝達システムCD47−SHPS-1系による神経突起形成の制御機構, 第８６回日本耳鼻咽喉科学会群馬県地方部会, 2007
• 受容体型チロシンホスファターゼSAP-1の機能解析, 第6回生体機能研究会, 2007
• 受容体型膜蛋白質CD47とSHPS-1のトランスエンドサイトーシスとその分子メカニズム Trans-endocytosis of CD47 and SHPS-1 and its molecular mechanism, Neuro2007 第30回日本神経科学大会 第50回日本神経化学会大会 第17回日本神経回路学会大会 合同大会, 2007
• EAEにおける CD47-SHPS-1シグナル系の解析, 第48回日本神経学会総会, 2007
• An essential role of SHPS-1 in proper development of dendritic cells for induction of Th17-mediated autoimmune diseases, 2007
• Regulation by CD47-SHPS-1 system of neurite development, Neurosciense 2007, 2007
• Regulation by SHPS-1 of Toll-like receptor-mediated cytokine production in macrophages, 第37回日本免疫学会総会・学術集会, 2007
• Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T cell Priming by Dendritic Cells in SHPS-1 Mutant Mice, 2007
• Regulation by SHPS-1 of skin immunity and of Toll-like receptor-mediated cytokine production SHPS-1による皮膚免疫とToll-like receptorを介したサイトカイン分泌の制御, 第37回日本免疫学会総会・学術集会, 2007
• Trans-endocytosis of CD47-SHPS-1 system and its molecular mechanism, 日本癌学会第66回総会, 2007
• 細胞間シグナルシステムCD47-SHPS-1系のトランスエンドサイトーシスによる制御, BMB2007, 2007
• CD47-SHPS-1系におけるトランスエンドサイトーシスの役割, 第54回北関東医学会総会, 2007
• Negative regulation by SHPS-1 of Toll-like receptor-mediated cytokine production in macrophages., EuroPhosphatases 2007 "Protein Phosphatases in Health and Disease", 2007
• Regulation by CD47 of epithelial cell spreading and migration and its signal transduction, EUROPHOSPATASE, 2007
• Spatio-temporal Dynamics of Tyrosine Phosphorylation of SHPS-1, COE International Seminnar by Young Scientists 2006, 2006
• An essential role of SHPS-1 in development of Th17-mediated inflammatory autoimmune diseases, EuroPhosphatases 2007 "Protein Phosphatases in Health and Disease", 2007
• 細胞間シグナル伝達システムCD47-SHPS-1系の機能, 日本動物細胞工学会 2007年度大会, 2007
• Regulation by CD47-SHPS-1 system of neurite development and its molecular mechanism, 第59回日本細胞生物学会大会 第40回日本発生生物学会大会 合同大会, 2007
• Roles of SHPS-1 and its family protein SIRPb in regulation of macrophage phagocytosis, 第59回日本細胞生物学会大会 第40回日本発生生物学会大会 合同大会, 2007
• 神経系における細胞間相互作用シグナルCD47-SHPS-1系の機能, 第143回日本獣医学会学術集会, 2007
• SHPチロシンホスファターゼ結合分子SHPS-1とAutoimmunity, 日本プロテインホスファターゼ研究会 第 ３ 回 国 内 集 会 “プロテインホスファターゼとシグナル分子 - 基礎と臨床 -”, 2007
• SHPS-1は糸球体上皮細胞に発現し、障害時の蛋白尿の制御に関与する, 第50回日本腎臓学会, 2008
• 受容体型膜蛋白質SHPS-1のインスリン分泌制御における機能解析, 第51回日本糖尿病学会年次学術集会, 2008
• CD47-SHPS-1シグナルシステムの機能とその分子機構, BMB2007, 2007
• SHPS-1によるToll-like receptorを介したサイトカイン産生の制御, BMB2007, 2007
• SHPS-1による皮膚免疫とToll様受容体を介したサイトカイン産生の制御, 日本癌学会第66回総会, 2007
• 受容体型チロシンホスファターゼSAP-1の機能解析, 基礎生物学研究所研究会「リン酸化シグナルの統合的理解を目指して」, 2008
• Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system, 第第8回国際プロテインホスファターゼカンファレンス, 2008
• Defective Development of Dendritic Cells in SHPS-1 Mutant Mice, 第第8回国際プロテインホスファターゼカンファレンス, 2008
• 腸微絨毛特異名発現を示すチロシンホスファターゼSAP-1による腸管腫瘍形成の制御, 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会, 2008
• 受容体型チロシンホスファターゼSAP-1のチロシンリン酸化とその生理的, 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会, 2008
• SAP-1 is a microvillus-specific protein tyrosine phosphatase that regulates intestinal tumorigenesis, FASEB Summer Research Conferences, 2008
• チロシンホスファターゼによるがん、炎症性腸炎の制御, 第67回日本癌学会学術総会, 2008
• Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) protects against podocyte injury, American Society of Nehrology, 2008
• 神経系における受容体型膜蛋白質SHPS-1の機能解析, 神経組織の成長・再生・移植研究会 第24回学術集会, 2009
• CD47-SIRPα系による樹状細胞機能制御, 第18回内毒素・LPS研究会, 2009
• SAP-1 is an intestinal microvillus-specific protein tyrosine phosphatase that protects against colitis in cooperation with IL-10, 第61回日本細胞生物学会大会, 2009
• Tyrosine phosphorylation of SAP-1, a receptor-type protein tyrosine phosphatase, and its association with Grb2, 第68回日本癌学会学術総会, 2009
• Promotion by VE-PTP of lamellipodium formation in cooperation with Ras and integrin, 第68回日本癌学会学術総会, 2009
• 脳におけるSHPS-1シグナルの解析, 第56回北関東医学会総会, 2009
• 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1とIL-10による炎症性腸疾患の制御, 第82回日本生化学会大会, 2009
• VE-PTPによるRas, インテグリン依存的なラメリポディア形成の促進, 第82回日本生化学会大会, 2009
• CD47-SIRPα系によるリンパ組織内樹状細胞の恒常性の制御, 第71回日本血液学会, 2009
• VE-PTPによるRas, インテグリン依存的な細胞形態制御, 第４回日本プロテインホスファターゼ研究会, 2009
• CD47-SIRPα系による樹状細胞の恒常性の制御, 第４回日本プロテインホスファターゼ研究会, 2009
• Expression of SHPS-1 in pancreatic beta cells and its role in promotion of insulin secretion and protection against diabetes, 第第8回国際プロテインホスファターゼカンファレンス, 2008
• Essential roles of SHPS-1 in homeostasis of dendritic cells, 第10回国際樹状細胞シンポジウム, 2008
• CD47とSHPS-1のトランスエンドサイトーシスとCD47-SHPS-1系の制御における役割, 第60回日本細胞生物学会, 2008
• SHPS-1は樹状細胞の恒常性に重要である, 第３８回日本免疫学会総会・学術集会, 2008
• 腸管におけるSHPS-1発現と腸管免疫制御, 第３８回日本免疫学会総会・学術集会, 2008
• クラス3受容体型チロシンホスファターゼの機能と病態への関与, 第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会, 2008
• 腸微絨毛特異的な発現を示すチロシンホスファターゼSAP-1による腸管腫瘍形成の制御., 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2009
• Stress-evoked tyrosine phosphorylation of SIRPalpha mediates an antidepressant effect, FASEB Summer Research Conferences, 2010
• Expression of PTPRO in the interneurons of adult mouse olfactory bulb, FASEB Summer Research Conferences, 2010
• Promotion by VE-PTP of lameripodium formation in cooperation with Ras and integrin, 第61回日本細胞生物学会大会, 2009
• 細胞間相互作用シグナルCD47-SIRPα系による脳のストレス応答制御, 第9回生体機能研究会, 2010
• CD47-SIRPα系による免疫機能制御, 第８回生体機能研究会, 2009
• チロシンリン酸化シグナルによる脳のストレス応答制御, 第52回日本神経化学会大会, 2009
• マウス嗅球のインターニューロンにおけるProtein tyrosine phosphatase receptor-type O (PTPRO)の発現, 第52回日本神経化学会大会, 2009
• チロシンリン酸化シグナルによる脳のストレス応答制御機構, 第４回グローバルCOE若手研究者シンポジウム, 2010
• Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrin, FASEB Summer Research Conferences, 2010
• 脳におけるSIRPαチロシンリン酸化の解析, 第57回北関東医学会総会, 2010
• Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues., 11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology, 2010
• CD47-SIRPa系の機能とヒト遺伝子多型, 第一回脳表現型の分子メカニズム研究会, 2010
• Stress-evoked tyrosine phosphorylation of SIRPα mediates an antidepressant effect, 40th Annual Meeting of Society for Neuroscience, Neuroscience 2010, 2010
• 低温ストレスによるSIRPαチロシンリン酸化の誘導, BMB２０１０ 第33回日本分子生物学会年会 第83回日本生化学会大会 合同年会, 2010
• 神経細胞間相互作用シグナルCD47-SIRPα系による脳のストレス応答制御機構, 第１回放射線神経生物学研究集会, 2011
• Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain, 発がんスパイラル第1回国際シンポジウム 第９回プロテインホスファターゼ国際カンファレンス, 2011
• 樹状細胞のチロシンホスファターゼSHP-1は自己免疫疾患発症に関与する, 第26回 日本整形外科学会基礎技術集会, 2011
• チロシンリン酸化シグナルによる脳のストレス応答機構, BMB２０１０ 第33回日本分子生物学会年会 第83回日本生化学会大会 合同年会, 2010
• 血管内皮細胞のシェアストレス刺激応答におけるVE-PTPの機能解析, BMB２０１０ 第33回日本分子生物学会年会 第83回日本生化学会大会 合同年会, 2010
• 腸微絨毛特異的な発現を示す受容体型チロシンキナーゼSAP-1とIL-10による炎症性腸疾患の制御, BMB２０１０ 第33回日本分子生物学会年会 第83回日本生化学会大会 合同年会, 2010
• Shear stress regulates cellular localization of vascular endothelial-protein tyrosine phosphatase (VE-PTP), 発がんスパイラル第1回国際シンポジウム 第９回プロテインホスファターゼ国際カンファレンス, 2011
• Stress-evoked tyrosine phosphorylation of SIRPα regulates depression-like behavior, Hiroshi Ohnishi; Takashi Matozaki, ISN-ESN-2011 23rd Biennial Meeting of the International Society for Neurochemistry jointly with the European Society for Neurochemistry, Aug. 2011, English, International conference
• チロシンリン酸化シグナルによるうつ様行動の制御 Regulation by protein tyrosine phosphorylation of depression-like behavior, 第34回日本神経科学大会 Neuroscience 2011 こころの脳科学 ―Neuroscience of the Mind―, 2011
• 脳内蛋白質チロシンリン酸化シグナルによるストレス応答制御, 平成23年度生理学研究所研究会 感覚刺激・薬物による快・不快情動生成機構とその破綻 提案代表者：喜田聡 生理研対応者：重本隆一 ―Neuroscience of the Mind―, 2011
• 樹状細胞特異的チロシンホスファターゼShp1欠損はTh1分化と自己免疫病を誘導する Dendritic cell-specific depletion of protein tyrosine phosphatase Shp1 promotes Th1 differentiation causes autoimmunity, 第40回日本免疫学会学術集会, 2011
• Regulation of brain functions by a protein tyrosine phosphatase Shp2, 平成24年度国際シナプス研究会 International Synapse Research Workshop 2012 "Understanding of synapse pathologyl, from genome mutation to functional defects", 2012
• Roles of vascular endothelial protein tyrosine phosphatase (VE-PTP) in endothelial cells, 2nd Bandung Biomolecular Medicine Conference, 2012
• Hypothermia-induced tyrosine phosphorylation of SIRPa in the brain, The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry The 55th Annual Meeting of the Japanese Society for Neurochemistry, 2012
• タンパク質チロシンリン酸化シグナルによる行動と脳機能の制御, 秋田大学生体情報研究センター設置記念シンポジウム グローバルCOEプログラム「生体調節シグナルの統合的研究」（群馬大学・秋田大学連携）のさらなる展開, 2012
• Signaling through direct cell-cell contact: functional roles of SIRP family membrane proteins in the brain, 新学術領域「脳内環境」夏のワークショップ, 2012
• 低温ストレスによる受容体型分子SIRPαのチロシンリン酸化誘導, 第30回内分泌代謝学サマーセミナー, 2012
• 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析, 第11回生体機能研究会, 2012
• IMPORTANCE OF THE PROTEIN TYROSINE PHOSPHATASE SHP1 IN DENDRITIC CELLS FOR PREVENTION OF TH1 CELL DIFFERENTIATION AND AUTOIMMUNITY: A POTENTIAL TARGET FOR THE THERAPY, EULAR2012 （European League Against Rheumatism 2012） （欧州リウマチ学会議）, 2012, International conference
• Regulation by protein tyrosine phosphorylation of depression-like behavior, Hiroshi Ohnishi; Takashi Matozaki, 第34回日本神経科学大会 Neuroscience 2011 こころの脳科学 ―Neuroscience of the Mind―, Sep. 2011, English, Domestic conference
• 腸微絨毛特異的な発現を示す受容体型チロシンホスファターゼSAP-1による腸管免疫制御, 第5回 日本プロテインホスファターゼ研究会学術集会, 2012
• 成熟脳におけるShp2の生理機能解析, 第5回 日本プロテインホスファターゼ研究会学術集会, 2012
• SIRPαを介した細胞間接触シグナルによる脳内免疫系制御機構, 新学術領域「脳内環境」冬のワークショップ, 2013
• Regulation of intestinal immunity by the protein tyrosine phosphatase SAP-1, 10th International Conference on Protein Phosphatase Protein Phosphatases and Diseases, 2013
• Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain, 10th International Conference on Protein Phosphatase Protein Phosphatases and Diseases, 2013
• Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell diffierentiation and induces autoimmunity, 10th International Conference on Protein Phosphatase Protein Phosphatases and Diseases, 2013
• Tyrosine phosphorylation of CEACAM20 and its functional roles, 10th International Conference on Protein Phosphatase Protein Phosphatases and Diseases, 2013
• 脾臓T細胞の恒常性調節へのSIRPαの関与 Signal regulatory protein alpha regulates the homeostasis of T lymphocytes in the spleen., 第85回日本生化学会大会, 2012
• 細胞質型チロシンホスファターゼShp2の成熟脳における機能解析 Functional analysis of tyrosine phosphatase Shp2 in the adult brain, 第85回日本生化学会大会, 2012
• The impact of ion dynamics on tyrosine phosphorylation of SIRPα, Daiki Jingu; Mika Iino; Shinya Kusakari; Miho Hashimoto; Hiroshi Ohnishi, The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase in Sendai / The 8th Japanese Conference on Protein Phosphatase, 19 Nov. 2017, English, 東北大学さくらホール, International conference
• SIRPα欠損マウスはLPS投与によって誘導される低体温症が重症化する, 橋本美穂; 野津智美; 浦野江里子; 齊藤泰之; 小谷武徳; 村田陽二; 的崎尚; 大西浩史, 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会, 08 Sep. 2016, English, 福岡国際会議場, Domestic conference
• 白質におけるミクログリア恒常性制御, 野津智美; 橋本美穂; Ruwaida Elhanbaly; 石川達也; 齊藤泰之; 小谷武徳; 村田陽二; 的崎尚; 深澤有吾; 大西浩史, 第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会, 10 Sep. 2016, English, 福岡国際会議場, Domestic conference
• SIRPα欠損マウスにおけるクプリゾン感受性の亢進, 野津智美; 橋本美穂; Ruwaida Elhanbaly; 石川達也; 齊藤泰之; 小谷武徳; 村田陽二; 深澤有吾; 的崎尚; 大西浩史, 第63回北関東医学会総会, 29 Sep. 2016, Japanese, 群馬大学刀城会館, Domestic conference
• LEOPARD症候群の多発性黒子の病態解明, 茂木精一郎; 横山洋子; 荻野幸子; 大西浩史; 石川治, 第63回北関東医学会総会, 29 Sep. 2016, Japanese, 群馬大学刀城会館, Domestic conference
• Analysis of a direct cell-cell communication signal that regulates glial acrivation in the brain, Tomomi Nozu; Miho Hashimoto; Ruwaida Elhanbaly; Tatsuya Ishikawa; Ayaka Hirose; Waka Shimizu; Takashi Matozaki; Yugo Fukazawa; Hiroshi Ohnishi, 12th International Conference on Protein Phosphatase International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics, 29 Oct. 2016, English, November HALL, International conference
• 遺伝子改変動物を用いた細胞間接触シグナルの機能解析, Hiroshi Ohnishi, 第2回分子細胞生物学基礎臨床連携セミナー, 02 Nov. 2016, Japanese, 獨協医科大学, Domestic conference
• Possible roles of thyroid hormones in hibernation control, Miho Sato-Hashimoto; Tsuneo Sakijima; Takashi Ohtsu; Taito Kamata; Hiroshi Ohnishi; Noriaki Kondo, The 22nd International Congress of Zoology/The 87th Meeting of Zoological Society of Japan Joint meeting, 18 Nov. 2016, English, Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa Convention Center (OCC), International conference
• Shp-1 in dendritic cells controls the development of memory-phenotype CD8+ T cells, OHISHI Yuko; KANEKO Yoriaki; KINOSHITA Masato; WATANABE Mitsuharu; HIROMURA Keiju; SAITO Yasuyuki; OHNISHI Hiroshi; MATOZAKI Takashi; NOJIMA Yoshihisa, 第45回日本免疫学会学術集会, 05 Dec. 2016, English, 沖縄コンベンションセンター Laguna Garden Hotel, Domestic conference
• Accumulation of dysregulated renal mononuclear phagocytes (rMoPh) and Th1 cells in the kidney of CD11c-specific Shp-1 knockout mice, WATANABE Mitsuharu; KANEKO Yoriaki; HIROMURA Keiju; KINOSHITA Masato; OHISHI Yuko; SAITO Yasuyuki; OHNISHI Hiroshi; MATZAKI Takashi; NOJIMA Yoshihisa, 第45回日本免疫学会学術集会, 07 Dec. 2016, English, 沖縄コンベンションセンター Laguna Garden Hotel, Domestic conference
• 細胞間接触シグナルによる脳内グリア恒常性制御, Hiroshi Ohnishi, The 6th Multidisciplinary meeting on atherosclerosis, 07 Jan. 2017, Japanese, 仙台トラストシティ, Domestic conference
• Regulation of microglia activation and tissue damage in white matter by a cell-cell contact signal, Hiroshi Ohnishi, Workshop on Frontiers in Phosphatase Research and Drug Discovery, 23 Oct. 2018, English, TMDU Akio, Suzuki Memorial Hall, International conference
• PPARsの活性化がアデノシンA1受容体作動薬による低体温を長期化する, Miho Hashimoto; Hiroshi Ohnishi, 第17回生体機能研究会, 28 Jul. 2018, Japanese, 群馬県(伊香保）, Domestic conference
• Study of stress-induced tyrosine phosphorylation of SIRPα in immortalized murine microglia cell line, Daiki Jingu; Ayaka Motai; Mika Iino; Joji Kawasaki; Kaori Imai; Miho Sato-Hashimoto; Takashi Matozaki; Hiroshi Ohnishi, 第40回日本生物学的精神医学会・第61回日本神経化学会大会, 06 Sep. 2018, English, 神戸国際会議場, Domestic conference
• A molecular signal that controls tissue damage and repair in the brain white matter, Hiromi Nagai; Miho Hashimoto; Ayano Horikoshi; Ruwaida Elhanbaly; Tatsuya Ishikawa; Takashi Matozaki; Yugo Fukasawa; Hiroshi Ohnishi, 第40回日本生物学的精神医学会・第61回日本神経化学会大会, 07 Sep. 2018, English, 神戸国際会議場, Domestic conference
• 哺乳類神経細胞に秘められた低温応答メカニズムの解明, 大西浩史, 新学術領域研究「温度生物学」第7回領域会議, 22 Nov. 2018, Japanese, 大阪大学南部陽一郎ホール, Domestic conference
• Activation of peroxisome proliferator-activated receptors exerts prolonged hypothermia induced by the adenosine A1 receptor agonist., Miho Sato-Hashimoto; Hiroshi Ohnishi, 第41回日本神経科学大会, 26 Jul. 2018, English, Kobe Convention Center, Kobe International Conference Center, Domestic conference
• 哺乳類神経細胞に秘められた低温応答メカニズムの解明, 大西浩史, 新学術領域研究「温度生物学」第6回領域会議, 26 Jun. 2018, Japanese, Okinawa Convention Center, Domestic conference
• Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp-1 induces autoimmune sialadenitis characterized by infiltration of CD4+T cells and B cells, Kinoshita Masato; Kaneko Yoriaki; Watanabe Mitsuharu; Ohishi Yuko; Saito Yasuyuki; Ohnishi Hiroshi; Nojima Yoshihisa; Matozaki Takashi; Hiromura Keiju, 第46回日本免疫学会学術集会, 12 Dec. 2017, English, 仙台国際センター, Domestic conference
• Regulation of Microglia Activation by A Cell-cell Communication Signal, Hiroshi Ohnishi; Miho Hashimoto; Tomomi Nozu; Ruwaida Elhanbaly; Tatsuya Ishikawa; Yugo Fukazawa; Takashi Matozaki, 第40回日本神経科学大会, 22 Jul. 2017, English, 幕張メッセ, Domestic conference
• The importance of ion dynamics for low temperature-induced tyrosine phosphorylation of SIRPα in neurons, Hiroshi Ohnishi; Shinya Kusakari; Miho Hashimoto; Kaori Imai; Eriko Urano; Takashi Matozaki, 第60回日本神経化学会, 07 Sep. 2017, English, 仙台国際センター, Domestic conference
• The effect of genetic ablation of CD47-SIRPα signal on microglial activation and pathology of demyelination, Ayano Horikoshi; Miho Hashimoto; Hiromi Nagai; Hiroshi Ohnishi, The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase in Sendai / The 8th Japanese Conference on Protein Phosphatase, 19 Nov. 2017, English, 東北大学さくらホール, International conference
• Study of stress-induced tyrosine phosphorylation of SIRPα in immortalized murine microglia cell line, Daiki Jingu; Ayaka Motai; Mika Iino; Joji Kawasaki; Kaori Imai; Miho Sato-Hashimoto; Hiroshi Ohnishi, Workshop on Frontiers in Phosphatase Research and Drug Discovery, 24 Oct. 2018, English, TMDU Akio, Suzuki Memorial Hall, International conference
• Analysis of stress-induced tyrosine phosphorylation of SIRPα in primary cultured neurons, Mika Iino; Joji Kawasaki; Daiki Jingu; Ayaka Motai; Kaori Imai; Miho Sato-Hashimoto; Hiroshi Ohnishi, Workshop on Frontiers in Phosphatase Research and Drug Discovery, 24 Oct. 2018, English, TMDU Akio, Suzuki Memorial Hall, International conference
• Control of microglia activation by SIRPα, Hiromi Nagai; Ayuto Shimoda; Tomomi Nozu; Ayano Horikoshi; Miho Akaike; Yuriko Hayashi; Miho Sato-Hashimoto; Hiroshi Ohnishi, Workshop on Frontiers in Phosphatase Research and Drug Discovery, 24 Oct. 2018, English, TMDU Akio, Suzuki Memorial Hall, International conference
• Lack of the check point signal for microglial activation improves age-related motor learining deficits, Asuka Tomiyama, Daisuke Yokota, Takeshi Imai, Joji Kawasaki, Akira Moriya, Mika Iino, Ayako Morita, Eriko Urano, Yuriko Hayashi, Miho Hashimoto, Hiroshi Ohnishi, The 14th International Conference on Protein Phosphatase, 10 Dec. 2020, 10 Dec. 2020, 12 Dec. 2020, English, Sysmex Hall in Kobe Univ Grad School of Med, Shinryoku Hall in Kobe Univ Grad School of Med, International conference
• Contribution of tyrosine phosphatase activity to the regulation of low temperature-induced tyrosine phosphorylation of SIRPα, Daiki Jingu, Joji Kawasaki, Taiki Kono, Mika Iino, Eriko Urano, Yuriko Hayashi, Hiroshi Ohnishi, The 14th International Conference on Protein Phosphatase, 10 Dec. 2020, 10 Dec. 2020, 12 Dec. 2020, English, Sysmex Hall in Kobe Univ Grad School of Med, Shinryoku Hall in Kobe Univ Grad School of Med, International conference
• ランニングホイールを用いた運動技能学習の加齢変化の解析, 本澤拓郎，尾池恵摘，榛澤春哉，守家優佳，松本映子，浦野江里子，林由里子，大西浩史, 第71回北関東医学会総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese, Japan
• 老化と発達におけるミクログリア活性化と受容体型分子SIRPαの関連解析, 榛澤春哉，上田瑞姫，尾池恵摘，守家優佳，本澤拓郎，松本映子，浦野江里子，林由里子，大西浩史, 第71回北関東医学会総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese, Japan
• CD11c陽性ミクログリア誘導制御メカニズムの解析, 守家優佳，仲丸優香，尾池恵摘，榛澤春哉，松本映子，浦野江里子，小林良祐，堀居拓郎，畑田出穂，林由里子，大西浩史, 第71回北関東医学会総会, 19 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese, Japan, Domestic conference
• マウス脳における保護型ミクログリア誘導制御メカニズムの解析, 守家優佳，尾池恵摘，榛澤春哉，雨宮咲良，仲丸優香，浦野江里子，松本映子，小林良祐，堀居拓郎，畑田出穂，林由里子，的崎尚，大西浩史, 2024年度 生化学会関東支部例会, 15 Jun. 2024, 15 Jun. 2024, 15 Jun. 2024, Japan, Domestic conference
• 受容体型分子 SIRPα の欠損がミクログリアの老化と発生に与える影響の解析, 榛澤春哉，尾池恵摘，守家優佳，本澤拓郎，上田瑞姫，浦野江里子，松本映子，林由里子，的崎尚，大西浩史, 2024年度 生化学会関東支部例会, 15 Jun. 2024, 15 Jun. 2024, 15 Jun. 2024, Japan, Domestic conference
• ミクログリア特異的SIRPα欠損マウス脳におけるアストロサイト活性化状態の解析, 尾池恵摘，榛澤春哉，守家優佳，雨宮咲久良，松本映子，浦野江里子，林由里子，大西浩史, 第22回生体機能研究会, 07 Sep. 2024, 06 Sep. 2024, 07 Sep. 2024, Japanese
• Analysis of age-dependent effects of receptor-type molecule SIRPα deficiency on microglia activation in mice, 榛澤春哉，尾池恵摘，守家優佳，本澤拓郎，上田瑞姫，松本映子，浦野江里子，林由里子，的崎尚，大西浩史, 第47回日本分子生物学会年会, 29 Nov. 2024, 27 Nov. 2024, 29 Nov. 2024, Japanese, Japan
• Analysis of the regulatory mechanism of CD11c-positive microglia induction by the membrane protein SIRPα, 守家優佳，尾池恵摘，榛澤春哉，仲丸優香，松本映子，浦野江里子，小林良祐，堀居拓郎，畑田出穂，林由里子，的崎尚，大西浩史, 第47回日本分子生物学会年会, 29 Nov. 2024, 27 Nov. 2024, 29 Nov. 2024, Japanese, Japan
• 老化型ミクログリアが秘める生体保護作用に基づく 脳疾患治療法の開発, 大西浩史，的崎尚, Brain/MINDS 2.0 脳神経科学統合プログラム キックオフ会議, 16 Oct. 2024, 15 Oct. 2024, 17 Oct. 2024, Japanese, Japan
• THE ASSOCIATION BETWEEN SIRPα SIGNALING AND AGE-RELATED INFLAMMATORY RESPONSES IN HUMAN MONOCYTES, Yuriko Hayashi, Ririka Arai, Rino Watanabe, Etsumi Oike, Hiroshi Ohnishi, FASEB Science Research Conferences Protein Phosphatases, 09 Dec. 2024, 08 Dec. 2024, 12 Dec. 2024, English, Palm Springs, California, USA, United States, International conference
• A CHECKPOINT SIGNAL OF MICROGLIA ACTIVATION IN MOUSE BRAIN, Hiroshi Ohnishi, Etsumi Oike, Yuka Moriya, Shunya Hanzawa , Takuro Honzawa, Yuka Nakamaru, Mizuki Ueda, Sakura Amemiya, Eiko Matsumoto, Eriko Urano, Takenori Kotani, Yoji Murata, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Yuriko Hayashi, Takashi Matozaki, FASEB Science Research Conferences Protein Phosphatases, 10 Dec. 2024, 08 Dec. 2024, 12 Dec. 2024, English, Palm Springs, California, USA, United States, International conference

Industrial Property Rights

• Patent right, US2005/244415 A 1, 特許米国特許第7,449,301号, 11 Nov. 2008
• Patent right, 特願2004-133599, 特許4224586, 05 Dec. 2008

Awards

• Oct. 2019
• May 2019
• 群馬健康医学振興会 平成30年度 群馬健康医学振興会研究助成, Hiroshi Ohnishi, Jul. 2018
• 群馬大学医学部保健学科ベストティーチャー賞, Hiroshi Ohnishi, 2017
• 平成28年度 群馬大学 一般研究助成, Hiroshi Ohnishi, 2016
• 第45回（2013年度）内藤記念科学奨励金・研究助成, Hiroshi Ohnishi, 2013
• 平成23年度 公益財団法人 武田科学振興財団 ビジョナリーリサーチ助成, Hiroshi Ohnishi, 2011
• 平成20年度 財団法人 ライフサイエンス振興財団 研究助成, Hiroshi Ohnishi, 2008
• 平成19年度 財団法人 武田科学振興財団 特定研究助成［II], Hiroshi Ohnishi, 2007
• 第21回（平成18年度）基礎医学医療研究助成, Hiroshi Ohnishi, 公益財団法人 金原一郎記念医学医療振興財団, 2006
• 2005
• 2005
• 第32回（平成17年度）大和証券ヘルス財団調査研究助成, Hiroshi Ohnishi, 2005
• 第22回（平成16年度）持田記念研究助成, Hiroshi Ohnishi, 2004
• 平成16年度 医科学応用財団調査研究助成, Hiroshi Ohnishi, 2004
• 平成16年度 群馬大学COE若手研究者奨励賞, Hiroshi Ohnishi, 2004
• 平成14年度 中島記念国際交流財団 日本人若手研究者研究助成, Hiroshi Ohnishi, 2002
• 平成14年度 ブレインサイエンス振興財団研究助成, Hiroshi Ohnishi, 2002
• 平成13年度 財団法人 大阪癌研究会 一般学術研究助成, Hiroshi Ohnishi, 2001
• 平成13年度 上原記念生命科学財団研究奨励, Hiroshi Ohnishi, 2001
• 平成13年度 臨床薬理研究振興財団研究助成, Hiroshi Ohnishi, 2001
• 平成13年度 公益信託 原口記念癌研究助成基金 研究助成, Hiroshi Ohnishi, 2001
• Oct. 2019
• May 2019
• Oct. 2020

Research Projects

• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, Apr. 2019, 9999
• Hiroshi Ohnishi, 群馬健康医学振興会, 平成30年度 群馬健康医学振興会研究助成金, Jul. 2018, Principal investigator, Competitive research funding
• 2018, 2019, Principal investigator, Competitive research funding

  対象リソースIRI
• 2018, 2021, Competitive research funding

  対象リソースIRI
• Hiroshi Ohnishi, 群馬大学, 平成28年度 群馬大学 一般研究助成, 2016, Principal investigator, Competitive research funding
• 2014, 2015, Principal investigator, Competitive research funding

  対象リソースIRI
• Search for a novel biological regulatory system based on low temperature biology, 大西浩史, 文部科学省, 科学研究費補助金(挑戦的萌芽研究), 2014, 2016, Principal investigator, Competitive research funding

  対象リソースIRI
• Molecular basis of the CD47-SIRP alpha signaling system in the regulation of physiological function, 的崎尚, 文部科学省, 科学研究費補助金(基盤研究(B)), 2014, 2016, Competitive research funding

  対象リソースIRI
• Study on a cold sensitive signal that regulates brain function, 大西浩史, 文部科学省, 科学研究費補助金(基盤研究(C)), 2013, 2016, Principal investigator, Competitive research funding

  対象リソースIRI
• 先天奇形症候群からの新規シナプス制御機構の解明, Hiroshi Ohnishi, 公益財団法人 内藤記念科学振興財団, 第45回（2013年度）内藤記念科学奨励金・研究助成, 2013, Principal investigator, Competitive research funding
• 2012, 2013, Principal investigator, Competitive research funding

  対象リソースIRI
• 低温バイオロジーにもとづく新たな脳機能制御法の開発, Hiroshi Ohnishi, 独立行政法人 科学技術振興機構, 研究成果展開事業 研究成果最適展開支援プログラム A-STEP フィージビリティスタディステージ【FS】探索タイプ, Aug. 2011, Mar. 2012, Principal investigator, Competitive research funding
• Analysis of the signaling mechanisms that regulates brain stress responses through protein tyrosine phosphorylation, 大西浩史, 文部科学省, 科学研究費補助金(基盤研究(C)), 2011, 2014, Principal investigator, Competitive research funding

  対象リソースIRI
• 病原蛋白質の細胞間感染メカニズム解明からめざす神経変性疾患の克服, Hiroshi Ohnishi, 公益財団法人 武田科学振興財団, 平成23年度 ビジョナリーリサーチ助成, 2011, Principal investigator, Competitive research funding
• The integrative research for regulation by protein tyrosine phosphatases of biological functions and its molecular mechanism, 的崎尚, 文部科学省, 科学研究費補助金(基盤研究(B)), 2011, 2013, Competitive research funding

  対象リソースIRI
• Molecular basis for regulation of the cellular life span, 的崎尚, 文部科学省, 科学研究費補助金(挑戦的萌芽研究), 2011, 2012, Competitive research funding

  対象リソースIRI
• 細胞間シグナルシステムを標的とした新規うつ診断法・抗うつ薬の開発, Hiroshi Ohnishi, 独立行政法人 科学技術振興機構, 平成21年度「シーズ発掘試験」（発掘型）重点地域研究開発推進プログラム, 2009, Principal investigator, Competitive research funding
• 新規細胞間シグナル伝達系によるうつ様行動の制御機構解明, Hiroshi Ohnishi, 財団法人 ライフサイエンス振興財団, 平成20年度 研究助成金, 2008, Principal investigator, Competitive research funding
• Physiological and pathological roles of CD47-SHPS-1 system, 的崎尚, 文部科学省, 科学研究費補助金(基盤研究(B)), 2008, 2010, Competitive research funding

  対象リソースIRI
• 2008, 2009, Principal investigator, Competitive research funding, 20022006

  対象リソースIRI
• 2008, 2010, Principal investigator, Competitive research funding, 20500332

  対象リソースIRI
• 新しい膜型分子間相互作用シグナルによる神経ストレス応答機構の解明：うつ病克服への新たなアプローチ, Hiroshi Ohnishi, 財団法人 武田科学振興財団, 平成19年度 特定研究助成［II], 2007, Principal investigator, Competitive research funding
• 神経細胞間相互作用シグナルによる脳内ストレス応答機構の解析, Hiroshi Ohnishi, 公益財団法人 金原一郎記念医学医療振興財団, 第21回（平成18年度）基礎医学医療研究助成金, 2006, Principal investigator, Competitive research funding
• 2006, 2007, Principal investigator, Competitive research funding, 18500288

  対象リソースIRI
• チロシンリン酸化シグナルによる神経機能制御機構の解明：脳機能維持・改善にむけた新戦略の創出, Hiroshi Ohnishi, 大和証券ヘルス財団, 第32回（平成17年度）調査研究助成, 2005, Principal investigator, Competitive research funding
• 2005, 2005, Principal investigator, Competitive research funding, 17024008

  対象リソースIRI
• 2005, 2009, Competitive research funding, 17014010

  対象リソースIRI
• Hiroshi Ohnishi, 群馬大学生体調節研究所, 平成16年度 若手研究支援経費, 2004, Principal investigator, Competitive research funding
• 細胞機能の負の制御システム「CD47-SHPS-1系」の生理機能と創薬への応用, Hiroshi Ohnishi, 公益財団法人 持田記念医学薬学振興財団, 第22回（平成16年度）持田記念研究助成金, 2004, Principal investigator, Competitive research funding
• チロシンリン酸化シグナルによるシナプス機能制御機構の解明：脳機能維持・改善の新たな戦略を目指して, Hiroshi Ohnishi, 医科学応用財団, 平成16年度 調査研究助成, 2004, Principal investigator, Competitive research funding
• Hiroshi Ohnishi, 群馬大学, 平成16年度 群馬大学COE若手研究者奨励賞, 2004, Principal investigator, Competitive research funding
• 2004, 2005, Principal investigator, Competitive research funding, 16500236

  対象リソースIRI
• 新規細胞間シグナルCD47-SHPS-1系による神経可塑性制御機構の解明, Hiroshi Ohnishi, 中島記念国際交流財団, 平成14年度 日本人若手研究者研究助成金, 2002, Principal investigator, Competitive research funding
• SHPS-1シグナルによる神経可塑性制御, Hiroshi Ohnishi, ブレインサイエンス振興財団, 平成14年度 研究助成, 2002, Principal investigator, Competitive research funding
• 2002, 2003, Principal investigator, Competitive research funding, 14780578

  対象リソースIRI
• 2002, 2004, Competitive research funding, 14028009

  対象リソースIRI
• 新しい細胞間シグナリングシステムCD47-SHPS-1系による細胞死誘導とがん治療への応用, Hiroshi Ohnishi, 財団法人 大阪癌研究会, 平成13年度 一般学術研究助成金, 2001, Principal investigator, Competitive research funding
• 新規シグナリングシステムCD47-SHPS-1系によるシナプス可塑性制御機構の解明, Hiroshi Ohnishi, 上原記念生命科学財団, 平成13年度 研究奨励金, 2001, Principal investigator, Competitive research funding
• 脳機能改善へむけたCD47-SHPS-1系によるシナプス可塑性制御機構の解明, Hiroshi Ohnishi, 臨床薬理研究振興財団, 平成13年度 研究助成金, 2001, Principal investigator, Competitive research funding
• 新しいシグナリング機構SHPS-1/CD47系の作用機構とがん治療への応用, Hiroshi Ohnishi, 公益信託 原口記念癌研究助成基金, 平成13年度 研究助成, 2001, Principal investigator, Competitive research funding
• 2001, 2001, Competitive research funding, 13216014

  対象リソースIRI
• Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Gunma University, Apr. 2019, Mar. 2022, 19H04027
• Hiroshi Ohnishi, Jul. 2024, Sep. 2025, Principal investigator, Competitive research funding

Research Grants & Projects

• 2024, 2026

Academic Contribution

• Academic society etc, 29 Sep. 2022, 30 Sep. 2022
• The 95th Annual Meeting of the Japanese Biochemical Society, Competition etc, The Japanese Biochemical Society, 11 Nov. 2022, 11 Nov. 2022
• Academic society etc, 17 Sep. 2020, 18 Sep. 2020
• Competition etc, 14 Sep. 2020, 16 Sep. 2020
• Academic society etc, 28 Sep. 2023, 29 Sep. 2023
• Academic society etc, 19 Sep. 2024, 20 Sep. 2023
• FASEB Science Research Conferences Protein Phosphatases, Academic society etc, 08 Dec. 2024, 12 Dec. 2024

Educational Activities

Awards

• Mar. 2020
• 26 Nov. 2023
• 25 Sep. 2023

Social Contribution

Academic Contribution

• 第69回北関東医学会総会, Academic society etc, 29 Sep. 2022, 30 Sep. 2022
• The 95th Annual Meeting of the Japanese Biochemical Society, Competition etc, The Japanese Biochemical Society, 09 Nov. 2022, 11 Nov. 2022
• 第19回生体機能研究会, Academic society etc, 17 Sep. 2020, 18 Sep. 2020
• 第93回日本生化学会大会, Competition etc, 14 Sep. 2020, 16 Sep. 2020
• 第70回北関東医学会総会, Academic society etc, 28 Sep. 2023, 28 Sep. 2023
• 第70回北関東医学会総会, Academic society etc, 28 Sep. 2023, 29 Sep. 2023
• 第71回北関東医学会総会, Academic society etc, 19 Sep. 2024, 20 Sep. 2024
• FASEB Science Research Conferences Protein Phosphatases, Academic society etc, FASEB & Japanese Association for Protein Phosphatase Research, 08 Dec. 2024, 12 Dec. 2024, International academic contribution

Media Coverage

• 脳内神経細胞の修復 仕組み一部解明, 13 Apr. 2019, Paper
• 免疫細胞 修復作用のみに 脳損傷 予防に期待, Myself, 11 Apr. 2019, Paper
• 群馬大、脳の修復阻害する分子を発見, Myself, 11 Apr. 2019, Internet
• 群馬大院などのグループ、脳内分子の作用発見 傷ついた脳の修復にブレーキ, Myself, 11 Apr. 2019, Internet
• 脳の修復阻害する分子を発見, Myself, 11 Apr. 2019, Paper
• 多発性硬化症やアルツハイマー治療に有用分子発見, 13 Apr. 2019, Internet