Researcher Profile and Settings

Researcher

• Name

  MATSUZAKI Yasunori

Affiliation

• Neurophysiology and Neural Repair, Assistant Professor

Profile and Settings

• Name

  Matsuzaki, Yasunori

Alternate Names

• Yasunori Matsuzaki
• Matsuzaki Y
• Y. Matsuzaki

ホームページ

• URI

  https://synapse.dept.med.gunma-u.ac.jp/

Affiliation

• Gunma University, Assistant Professor
• Gunma University, Assistant Professor, 研究科講師

Affiliation

• Affiliation

  Graduate School of Medicine, Neurophysiology and Neural Repair

• Job title

  Assistant Professor

Education

• Apr. 2010, Mar. 2014, Gunma University, Graduate School of Medicine, Neurophysiology and Neural Repair
• Apr. 2008, Mar. 2010, Shinshu University, Graduate School of Medicine, Human Science
• Apr. 2004, Mar. 2008, Kindai University, Faculty of Biology-Oriented Science and Technology, Department of Genetic Engineering

Association Memberships

• The Japan Neuroscience Society, 2019
• JAPAN SOCIETY OF MARMOSET RESEARCH, 2010, 9999
• The Japan Neuroscience Society, May 2019, 9999
• Japan Society of Gene and Cell Therapy, Jun. 2023, 9999
• The Society of Primate Diseases and Pathology, Jun. 2022, 9999

Research Experience

• Jul. 2015, 9999, Gunma University, Graduate School of Medicine Neurophysiology and Neural Repair, Assistant Professor, Assistant prof lv
• Apr. 2015, Jun. 2015, Gunma University, Graduate School of Medicine Neurophysiology and Neural Repair, Postdoctoral Researcher, Researcher postdoc lv
• Apr. 2014, Mar. 2015, Gunma University, Graduate School of Medicine Neurophysiology and Neural Repair, Postdoctoral Researcher, Researcher postdoc lv

Research Activities

Research Areas

• Life sciences, Animals: biochemistry, physiology, behavioral science
• Life sciences, Neuroscience - general

Research Interests

• neuroscience
• non-human primate
• marmoset
• gene therapy
• adeno-associated viral vector
• lentiviral vector
• molecular biology

Published Papers

• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Putri T. Radhiyanti; Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, Jun. 2021, Neuroscience Letters, 756, 135956, 135956, Scientific journal

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia., Hiroyuki Yasui; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, 08 Apr. 2020, Neuroscience, 462, 328, 336, Scientific journal

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Masashi Watanave; Chiaki Hoshino; Ayumu Konno; Yumi Fukuzaki; Yasunori Matsuzaki; Tohru Ishitani; Hirokazu Hirai, Jan. 2019, Neurobiology of disease, 121, 263, 273

  DOI
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning., Masashi Watanave; Yasunori Matsuzaki; Yasuyo Nakajima; Atsushi Ozawa; Masanobu Yamada; Hirokazu Hirai, 2018, Frontiers in cellular neuroscience, 12, 490, 490, Scientific journal

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Shinya Kusakari; Fumihito Saitow; Yukio Ago; Koji Shibasaki; Miho Sato-Hashimoto; Yasunori Matsuzaki; Takenori Kotani; Yoji Murata; Hirokazu Hirai; Toshio Matsuda; Hidenori Suzuki; Takashi Matozaki; Hiroshi Ohnishi, May 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572, Scientific journal

  DOI
• Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus, Koichiro Yamada; Tomonori Tsukahara; Kazuhisa Yoshino; Katsuhiko Kojima; Hideyuki Agawa; Yuki Yamashita; Yuji Amano; Mariko Hatta; Yasunori Matsuzaki; Naoki Kurotori; Keiko Wakui; Yoshimitsu Fukushima; Ryosuke Osada; Tanri Shiozawa; Kazuo Sakashita; Kenichi Koike; Satoru Kumaki; Nobuyuki Tanaka; Toshikazu Takeshita, Sep. 2009, RETROVIROLOGY, 6, 79, Scientific journal

  DOI
• The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice, Miho Oue; Hiroshi Handa; Yasunori Matsuzaki; Kazutomo Suzue; Hirokazu Murakami; Hirokazu Hirai, Nov. 2012, PLOS ONE, 7, 11, e51015, Scientific journal

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Akira Iizuka; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Jul. 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889, Scientific journal

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Mamiko Suzuki; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry K. Y. Chan; Hirokazu Hirai, Nov. 2016, PLOS ONE, 11, 11, e0164202, Scientific journal

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Yoichiro Shinohara; Ayumu Konno; Nobutaka Takahashi; Yasunori Matsuzaki; Shoji Kishi; Hirokazu Hirai, Aug. 2016, PLOS ONE, 11, 8, e0162023, Scientific journal

  DOI
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter, Yasunori Matsuzaki; Miho Oue; Hirokazu Hirai, Feb. 2014, JOURNAL OF NEUROSCIENCE METHODS, 223, 133, 143, Scientific journal

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Fathul Huda; Ayumu Konno; Yasunori Matsuzaki; Hanna Goenawan; Koichi Miyake; Takashi Shimada; Hirokazu Hirai, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1, 14032, Scientific journal

  DOI
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells, Tomohiko Irie; Yasunori Matsuzaki; Yuko Sekino; Hirokazu Hirai, Jan. 2014, JOURNAL OF PHYSIOLOGY-LONDON, 592, 1, 229, 247, Scientific journal

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Yasunori Matsuzaki; Ayumu Konno; Ryo Mukai; Fumiaki Honda; Masafumi Hirato; Yuhei Yoshimoto; Hirokazu Hirai, Apr. 2017, MOLECULAR NEUROBIOLOGY, 54, 3, 1745, 1758, Scientific journal

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Keisuke Nitta; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Sep. 2017, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 6, 159, 170, Scientific journal

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells, Nobutaka Takahashi; Anton N. Shuvaev; Ayumu Konno; Yasunori Matsuzaki; Masashi Watanave; Hirokazu Hirai, Dec. 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 660, 670, Scientific journal

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Yasunori Matsuzaki; Ayumu Konno; Ryuta Mochizuki; Yoichiro Shinohara; Keisuke Nitta; Yukihiro Okada; Hirokazu Hirai, 05 Feb. 2018, Neuroscience Letters, 665, 182, 188, Scientific journal

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination, Masashi Watanave; Nobutaka Takahashi; Nobutake Hosoi; Ayumu Konno; Hikaru Yamamoto; Hiroyuki Yasui; Mika Kawachi; Takuro Horii; Yasunori Matsuzaki; Izuho Hatada; Hirokazu Hirai, 15 Feb. 2022, Proceedings of the National Academy of Sciences, 119, 7, e2113336119, e2113336119, Scientific journal

  DOI
• The murine stem cell virus promoter drives correlated transgene expression in the leukocytes and cerebellar Purkinje cells of transgenic mice., Oue Miho;Handa Hiroshi;Matsuzaki Yasunori;Suzue Kazutomo;Murakami Hirokazu;Hirai Hirokazu, 30 Nov. 2012, PloS one, 7, 11

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Huda, Fathul;Konno, Ayumu;Matsuzaki, Yasunori;Goenawan, Hanna;Miyake, Koichi;Shimada, Takashi;Hirai, Hirokazu, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1

  DOI
• The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice, Oue, Miho;Handa, Hiroshi;Matsuzaki, Yasunori;Suzue, Kazutomo;Murakami, Hirokazu;Hirai, Hirokazu, 2012, PLOS ONE, 7, 11

  DOI
• Kv3.3 channels harboring a missense mutation of spinocerebellar ataxia type 13 alter neuronal excitability and induce apoptotic cell death in cultured cerebellar Purkinje cells of mice, Irie, Tomohiko;Matsuzaki, Yasunori;Sekino, Yuko;Hirai, Hirokazu, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S244, S244
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells, Irie, Tomohiko;Matsuzaki, Yasunori;Sekino, Yuko;Hirai, Hirokazu, 2014, JOURNAL OF PHYSIOLOGY-LONDON, 592, 1, 229, 247

  DOI
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter, Matsuzaki, Yasunori;Oue, Miho;Hirai, Hirokazu, 2014, JOURNAL OF NEUROSCIENCE METHODS, 223, 133, 143

  DOI
• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Kusakari, Shinya;Saitow, Fumihito;Ago, Yukio;Shibasaki, Koji;Sato-Hashimoto, Miho;Matsuzaki, Yasunori;Kotani, Takenori;Murata, Yoji;Hirai, Hirokazu;Matsuda, Toshio;Suzuki, Hidenori;Matozaki, Takashi;Ohnishi, Hiroshi, 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572

  DOI
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry;Hirai, Hirokazu, 2015, MOLECULAR THERAPY, 23, S237, S237
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Iizuka, Akira;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Shinohara, Yoichiro;Konno, Ayumu;Takahashi, Nobutaka;Matsuzaki, Yasunori;Kishi, Shoji;Hirai, Hirokazu, 2016, PLOS ONE, 11, 8

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Huda, Fathul;Fan, Yiping;Suzuki, Mamiko;Konno, Ayumu;Matsuzaki, Yasunori;Takahashi, Nobutaka;Chan, Jerry K. Y.;Hirai, Hirokazu, 2016, PLOS ONE, 11, 11

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Matsuzaki, Yasunori;Konno, Ayumu;Mukai, Ryo;Honda, Fumiaki;Hirato, Masafumi;Yoshimoto, Yuhei;Hirai, Hirokazu, 2017, MOLECULAR NEUROBIOLOGY, 54, 3, 1745, 1758

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Nitta, Keisuke;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2017, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 6, 159, 170

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells, Takahashi, Nobutaka;Shuvaev, Anton N.;Konno, Ayumu;Matsuzaki, Yasunori;Watanave, Masashi;Hirai, Hirokazu, 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 660, 670

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Matsuzaki, Yasunori;Konno, Ayumu;Mochizuki, Ryuta;Shinohara, Yoichiro;Nitta, Keisuke;Okada, Yukihiro;Hirai, Hirokazu, 2018, NEUROSCIENCE LETTERS, 665, 182, 188

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor a function mitigates spinocerebellar ataxia type 3 pathology, Watanave, Masashi;Hoshino, Chiaki;Konno, Ayumu;Fukuzaki, Yumi;Matsuzaki, Yasunori;Ishitani, Tohru;Hirai, Hirokazu, 2019, NEUROBIOLOGY OF DISEASE, 121, 263, 273

  DOI
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning, Watanave, Masashi;Matsuzaki, Yasunori;Nakajima, Yasuyo;Ozawa, Atsushi;Yamada, Masanobu;Hirai, Hirokazu, 2018, FRONTIERS IN CELLULAR NEUROSCIENCE, 12

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice, Matsuzaki, Yasunori;Tanaka, Masami;Hakoda, Sachiko;Masuda, Tatsuki;Miyata, Ryota;Konno, Ayumu;Hirai, Hirokazu, 2019, MOLECULAR THERAPY, 27, 4, 700, 704

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System, Shinohara, Yoichiro;Konno, Ayumu;Nitta, Keisuke;Matsuzaki, Yasunori;Yasui, Hiroyuki;Suwa, Junya;Hiromura, Keiju;Hirai, Hirokazu, 2019, MOLECULAR NEUROBIOLOGY, 56, 6, 4203, 4214

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor a in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia, Yasui, Hiroyuki;Matsuzaki, Yasunori;Konno, Ayumu;Hirai, Hirokazu, 2021, NEUROSCIENCE, 462, 328, 336

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB, Radhiyanti, Putri T.;Konno, Ayumu;Matsuzaki, Yasunori;Hirai, Hirokazu, 2021, NEUROSCIENCE LETTERS, 756

  DOI
• Protein kinase C gamma in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination, Watanave, Masashi;Takahashi, Nobutaka;Hosoi, Nobutake;Konno, Ayumu;Yamamoto, Hikaru;Yasui, Hiroyuki;Kawachi, Mika;Horii, Takuro;Matsuzaki, Yasunori;Hatada, Izuho;Hirai, Hirokazu, 2022, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119, 7

  DOI
• リピート病における神経変性の分子機構解明を目指して　アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, ;;;;;, Dec. 2017, 2017年度, [3PW23
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells., Irie Tomohiko;Matsuzaki Yasunori;Sekino Yuko;Hirai Hirokazu, 11 Nov. 2013, The Journal of physiology, 592, 1

  DOI
• Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter., Matsuzaki Yasunori;Oue Miho;Hirai Hirokazu, 19 Dec. 2013, Journal of neuroscience methods, 223

  DOI
• Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice., Kusakari Shinya;Saitow Fumihito;Ago Yukio;Shibasaki Koji;Sato-Hashimoto Miho;Matsuzaki Yasunori;Kotani Takenori;Murata Yoji;Hirai Hirokazu;Matsuda Toshio;Suzuki Hidenori;Matozaki Takashi;Ohnishi Hiroshi, 23 Feb. 2015, Molecular and cellular biology, 35, 9

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model., Huda Fathul;Konno Ayumu;Matsuzaki Yasunori;Goenawan Hanna;Miyake Koichi;Shimada Takashi;Hirai Hirokazu, 06 Aug. 2014, Molecular therapy. Methods & clinical development, 1

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα., Iizuka Akira;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 30 Jun. 2015, Brain structure & function, 221, 6

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors., Matsuzaki Yasunori;Konno Ayumu;Mukai Ryo;Honda Fumiaki;Hirato Masafumi;Yoshimoto Yuhei;Hirai Hirokazu, 16 Feb. 2016, Molecular neurobiology, 54, 3

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains., Shinohara Yoichiro;Konno Ayumu;Takahashi Nobutaka;Matsuzaki Yasunori;Kishi Shoji;Hirai Hirokazu, 29 Aug. 2016, PloS one, 11, 8

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice., Huda Fathul;Fan Yiping;Suzuki Mamiko;Konno Ayumu;Matsuzaki Yasunori;Takahashi Nobutaka;Chan Jerry K Y;Hirai Hirokazu, 01 Nov. 2016, PloS one, 11, 11

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates., Nitta Keisuke;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 27 Jul. 2017, Molecular therapy. Methods & clinical development, 6

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells., Takahashi Nobutaka;Shuvaev Anton N;Konno Ayumu;Matsuzaki Yasunori;Watanave Masashi;Hirai Hirokazu, 29 Nov. 2017, Journal of neurochemistry, 143, 6

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain., Matsuzaki Yasunori;Konno Ayumu;Mochizuki Ryuta;Shinohara Yoichiro;Nitta Keisuke;Okada Yukihiro;Hirai Hirokazu, 24 Nov. 2017, Neuroscience letters, 665

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System., Shinohara Yoichiro;Konno Ayumu;Nitta Keisuke;Matsuzaki Yasunori;Yasui Hiroyuki;Suwa Junya;Hiromura Keiju;Hirai Hirokazu, 05 Oct. 2018, Molecular neurobiology, 56, 6

  DOI
• Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology., Watanave Masashi;Hoshino Chiaki;Konno Ayumu;Fukuzaki Yumi;Matsuzaki Yasunori;Ishitani Tohru;Hirai Hirokazu, 19 Oct. 2018, Neurobiology of disease, 121

  DOI
• Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning., Watanave Masashi;Matsuzaki Yasunori;Nakajima Yasuyo;Ozawa Atsushi;Yamada Masanobu;Hirai Hirokazu, 12 Dec. 2018, Frontiers in cellular neuroscience, 12

  DOI
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice., Matsuzaki Yasunori;Tanaka Masami;Hakoda Sachiko;Masuda Tatsuki;Miyata Ryota;Konno Ayumu;Hirai Hirokazu, 28 Feb. 2019, Molecular therapy : the journal of the American Society of Gene Therapy, 27, 4

  DOI
• Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia., Yasui Hiroyuki;Matsuzaki Yasunori;Konno Ayumu;Hirai Hirokazu, 08 Apr. 2020, Neuroscience, 462

  DOI
• Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB., Radhiyanti Putri T;Konno Ayumu;Matsuzaki Yasunori;Hirai Hirokazu, 11 May 2021, Neuroscience letters, 756

  DOI
• Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination., Watanave Masashi;Takahashi Nobutaka;Hosoi Nobutake;Konno Ayumu;Yamamoto Hikaru;Yasui Hiroyuki;Kawachi Mika;Horii Takuro;Matsuzaki Yasunori;Hatada Izuho;Hirai Hirokazu, Proceedings of the National Academy of Sciences of the United States of America, 119, 7

  DOI
• A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant., Hayato Kawabata; Ayumu Konno; Yasunori Matsuzaki; Hirokazu Hirai, 08 Jun. 2023, Molecular therapy. Methods & clinical development, 29, 81, 92, Scientific journal

  DOI
• Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization, Hayato Kawabata; Ayumu Konno; Yasunori Matsuzaki; Yumika Sato; Mika Kawachi; Ryo Aoki; Saki Tsutsumi; Shota Togai; Ryosuke Kobayashi; Takuro Horii; Izuho Hatada; Hirokazu Hirai, Mar. 2024, Molecular Therapy - Methods & Clinical Development, 32, 1, 101185, 101185, Scientific journal

  DOI
• Protein kinase Cγ negatively regulates the intrinsic excitability in zebrin-negative cerebellar Purkinje cells, Masashi Watanave; Mika Kawachi; Ayumu Konno; Ryo Aoki; Yuuki Fukai; Yasunori Matsuzaki; Ryosuke Kaneko; Hirokazu Hirai, 16 Feb. 2024, Frontiers in Cellular Neuroscience, 18, Scientific journal

  DOI
• Development of microglia-targeting adeno-associated viral vectors as tools to study microglial behavior in vivo, Yukihiro Okada; Nobutake Hosoi; Yasunori Matsuzaki; Yuuki Fukai; Akito Hiraga; Junichi Nakai; Keisuke Nitta; Yoichiro Shinohara; Ayumu Konno; Hirokazu Hirai, 11 Nov. 2022, Communications Biology, 5, 1, Scientific journal

  DOI
• Optimal AAV capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex, Yasunori Matsuzaki; Yuuki Fukai; Ayumu Konno; Hirokazu Hirai, 10 May 2024, Mol Ther Methods Clin Dev, 32, 4, Scientific journal

  DOI
• Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System, Yoichiro Shinohara; Ayumu Konno; Keisuke Nitta; Yasunori Matsuzaki; Hiroyuki Yasui; Junya Suwa; Keiju Hiromura; Hirokazu Hirai, 01 Jun. 2019, Molecular Neurobiology, 56, 6, 4203, 4214, Scientific journal

  DOI

MISC

• Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice, Shinya Kusakari; Fumihito Saitow; Yukio Ago; Koji Shibasaki; Miho Sato-Hashimoto; Yasunori Matsuzaki; Takenori Kotani; Yoji Murata; Hirokazu Hirai; Toshio Matsuda; Hidenori Suzuki; Takashi Matozaki; Hiroshi Ohnishi, May 2015, MOLECULAR AND CELLULAR BIOLOGY, 35, 9, 1557, 1572

  DOI
• Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha, Akira Iizuka; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Jul. 2016, BRAIN STRUCTURE & FUNCTION, 221, 6, 2879, 2889

  DOI
• Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Mamiko Suzuki; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry K. Y. Chan; Hirokazu Hirai, Nov. 2016, PLOS ONE, 11, 11, e0164202

  DOI
• Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains, Yoichiro Shinohara; Ayumu Konno; Nobutaka Takahashi; Yasunori Matsuzaki; Shoji Kishi; Hirokazu Hirai, Aug. 2016, PLOS ONE, 11, 8, e0162023

  DOI
• Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model, Fathul Huda; Ayumu Konno; Yasunori Matsuzaki; Hanna Goenawan; Koichi Miyake; Takashi Shimada; Hirokazu Hirai, 2014, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 1, UNSP 14032

  DOI
• Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells, Tomohiko Irie; Yasunori Matsuzaki; Yuko Sekino; Hirokazu Hirai, Jan. 2014, JOURNAL OF PHYSIOLOGY-LONDON, 592, 1, 229, 247

  DOI
• One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice, H. Saida; Y. Matsuzaki; K. Takayama; A. Iizuka; A. Konno; S. Yanagi; H. Hirai, Sep. 2014, GENE THERAPY, 21, 9, 820, 827

  DOI
• Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors, Yasunori Matsuzaki; Ayumu Konno; Ryo Mukai; Fumiaki Honda; Masafumi Hirato; Yuhei Yoshimoto; Hirokazu Hirai, Apr. 2017, MOLECULAR NEUROBIOLOGY, 54, 3, 1745, 1758

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Keisuke Nitta; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, Sep. 2017, MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 6, 159, 170

  DOI
• Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells, Nobutaka Takahashi; Anton N. Shuvaev; Ayumu Konno; Yasunori Matsuzaki; Masashi Watanave; Hirokazu Hirai, Dec. 2017, JOURNAL OF NEUROCHEMISTRY, 143, 6, 660, 670

  DOI
• Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates, Keisuke Nitta; Yasunori Matsuzaki; Ayumu Konno; Hirokazu Hirai, 15 Sep. 2017, Molecular Therapy - Methods and Clinical Development, 6, 159, 170

  DOI
• Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain, Yasunori Matsuzaki; Ayumu Konno; Ryuta Mochizuki; Yoichiro Shinohara; Keisuke Nitta; Yukihiro Okada; Hirokazu Hirai, 05 Feb. 2018, Neuroscience Letters, 665, 182, 188

  DOI
• Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice, Fathul Huda; Yiping Fan; Ayumu Konno; Yasunori Matsuzaki; Nobutaka Takahashi; Jerry Chan; Hirokazu Hirai, May 2015, MOLECULAR THERAPY, 23, S237, S237, Summary international conference
• Kv3.3 channels harboring a missense mutation of spinocerebellar ataxia type 13 alter neuronal excitability and induce apoptotic cell death in cultured cerebellar Purkinje cells of mice, Tomohiko Irie; Yasunori Matsuzaki; Yuko Sekino; Hirokazu Hirai, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S244, S244, Summary international conference
• リピート病における神経変性の分子機構解明を目指して アデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発, 今野 歩; 渡邊 将; 星野 千秋; 篠原 洋一郎; 松崎 泰教; 平井 宏和, Dec. 2017, 2017年度, [3PW23, 3]
• 小脳失調症の原因である変異型Kv3.3は培養小脳プルキンエ細胞の樹状突起発達不全と細胞死を引き起こす, 入江 智彦; 松崎 泰教; 関野 祐子; 平井 宏和, Jul. 2013, 75, 4, 187, 187
• Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice, Yasunori Matsuzaki; Masami Tanaka; Sachiko Hakoda; Tatsuki Masuda; Ryota Miyata; Ayumu Konno; Hirokazu Hirai, 10 Apr. 2019, Molecular Therapy, 27, 4, 700, 704, Report scientific journal

  DOI

Presentations

• Mouse strain-dependent BBB (blood-brain barrier) permeability of AAV-PHP.B, Matsuzaki Yasunori, 9th FAOPS (Federation of the Asian and Oceanian Physiological Societies), Mar. 2019, English, International conference
• One-year follow-up of transgene expression by integrase-defective lentiviralvectors and their therapeutic potential in inherited polyglutaminedisease model mice, Matsuzaki Yasunori, International Society of Radiation Neurobiology 5th Conference, 21 Feb. 2015, English, International conference
• Efficient Gene Transfer into the Marmoset Central Nervous System Using AAV9 Vectors, Matsuzaki Yasunori, 第5回日本マーモセット研究会大会, 17 Jan. 2016, Japanese, Domestic conference
• Minimal Purkinje Cell-Specific L7 Promoter Virally Available for Rodents and Non-human Primates, Matsuzaki Yasunori, 9th symposium of the Society for Research on the Cerebellum and Ataxias, 17 May 2018, English, International conference
• Generation of neurodegenerative disease model mice using the altered neuron-specific synapsin I promoter, Matsuzaki Yasunori, 第19回日本遺伝子治療学会学術集会, 05 Jul. 2013, English, Domestic conference
• 中枢神経系の神経細胞t特異的に導入遺伝子が発現する遺伝子組換えマウスの作出と解析, 松﨑 泰教, Neuro2013 (第36回日本神経科学大会), 20 Jun. 2013, English, Domestic conference
• インテグレースを欠損させたレンチウイルスベクターによる一年間の遺伝子発現の経過観察と遺伝性神経変性疾患モデルマウスを用いた遺伝子治療での有効性の検討, 松﨑 泰教, 第37回日本神経科学大会, 13 Sep. 2014, English, Domestic conference
• アデノ随伴ウイルスベクター血清型9(AAV9)および血液脳関門突破型AAVベクター(AAV-PHP.B)のマーモセット静脈内投与および中枢神経系での発現比較, 松﨑 泰教, 第7回日本マーモセット研究会大会, 17 Jan. 2018, Japanese, Domestic conference
• Efficient Gene Transfer into the Marmoset Central Nervous System Using AAV9 vector, Matsuzaki Yasunori, 第6回日本マーモセット研究会大会, 12 Dec. 2016, Japanese, Domestic conference
• 群馬大学におけるコモンマーモセット飼育管理, 松﨑 泰教, 第4回日本マーモセット研究会大会, 22 Jan. 2015, Japanese, Domestic conference
• BBB-permeable properties of AAV-PHP.B are shared among diverse inbred strains of mice, Yasunori Matsuzaki; Masami Tanaka; SyokoHakoda; Ryuki Masuda; Ryota Miyata; Hirokazu Hirai, Neuro 2019, 26 Jul. 2019, 25 Jul. 2019, 28 Jul. 2019, English
• Cell type analysis of the gene expression of nine AAV capsid vectors in the cerebral cortex of the common marmoset., Yasunori Matsuzaki; Yuki Fukai; Ayumu Konno; Hirokazu Hirai, The 13th International Society of Radiation Neurobiology Conference, 09 Mar. 2024, 09 Mar. 2024, 09 Mar. 2024, English
• Expression analysis of 9 AAV capsid vectors in marmoset cortex injection, Yasunori Matsuzaki; Yuki Fukai; Ayumu Konno; Hirokazu Hirai, The 13th Annual Meeting of Japan Society for Marmoset Research, 20 Feb. 2024, 20 Feb. 2024, 21 Feb. 2024, Japanese
• Comparative analysis of nine AAV capsid vector-expressing cell types in the cerebral cortex of the marmoset, Yasunori Matsuzaki; Yuki Fukai; Ayumu Konno; Hirokazu Hirai, The 29th Annual Meeting of Japan Society of Gene and Cell Therapy, 12 Sep. 2023, 11 Sep. 2023, 13 Sep. 2023, Japanese
• Development of a method to keep three newborn marmosets in parental care by supplemental feeding, Yasunori Matsuzaki; Hirokazu Hirai, The 12th Annual Meeting of Japan Society for Marmoset Research, 08 Feb. 2023, 07 Feb. 2023, 08 Feb. 2023, Japanese
• Optimal combinations of adeno-associated viral capsids and brain-cell-type-specific promoters in the common marmoset cerebral cortex, 松﨑 泰教; 深井 悠貴; 今野 歩; 平井 宏和, 第14回日本マーモセット研究会大会, 28 Jan. 2025, 28 Jan. 2025, 29 Jan. 2025, Japanese
• Comparative analysis of transgene expression using nine AAV capsids in the cerebral cortex of the common marmoset, Yasunori Matsuzaki; Yuuki Fukai; Ayumu Konno; Hirokazu Hirai, NEURO2024, 26 Jul. 2024, 24 Jul. 2024, 27 Jul. 2024, English

Awards

• Jan. 2025

  共同研究・競争的資金等の業績ID対象リソースIRI

Research Projects

• Aug. 2014, Mar. 2015, Principal investigator, Competitive research funding
• Apr. 2017, Mar. 2019, Principal investigator, Competitive research funding
• Jul. 2014, Mar. 2015, Principal investigator, Competitive research funding
• Development of an assisted feeding method for three common marmosets at birth that balances ethical considerations and research advancement., Gunma University, Sep. 2022, Mar. 2023, Principal investigator
• Development of gene therapy against neurodegenerative diseases using CRISPR/Cas9-based genome editing, Hirai Hirokazu; HOSOI Nobutake; KONNO Ayumu; MATSUZAKI Yasunori, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Gunma University, 01 Apr. 2016, 31 Mar. 2018, In this research, we aimed to establish a technique that allows elimination of a disease-causing gene from specific cell populations in the brain, using adeno-associated virus (AAV) vectors in combination with CRISPR/Cas9 system. Initially, we characterized neuron-specific, astrocyte-specific and cerebellar Purkinje cell-specific promoters available for AAV vector-mediated transgene expression. The results were published in 3 papers. Then, using the AAV vectors, we examined whether a gene responsible for developmental defects of the brain could be knocked out from Purkinje cells by CRISPR/Cas9 system. The results showed successful removal of the gene from around two thirds of Purkinje cells., 16K15477

  対象リソースIRI
• Elucidation of cellular and nuclear signals that regulate motor learning, Hirai Hirokazu; HOSOI Nobutake; KONNO Ayumu; MATSUZAKI Yasunori, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Gunma University, 01 Apr. 2015, 31 Mar. 2018, Decrease of several genes including transient receptor potential cation channel type 3 (TRPC3), inositol trisphosphate (IP3) receptor and Homer protein homolog 3 (HOMER3) were found in the cerebellum of spinocerebellar ataxia type 1 (SCA1) knock-in mouse. We identified retinoid-related orphan receptor α (RORα), which is a transcription factor that could regulate expression of those genes. Moreover, we found that a gene “X” is increased more than 3 times in SCA1 knock-in mice 3 h after treatment with baclofen and rotarod training. Since haploinsufficiency of the gene “X” is known to cause mental retardation, upregulation of the gene “X” may play a key role in baclofen-induced improvement of motor learning in SCA1 mice., 15H04254

  対象リソースIRI
• 01 Apr. 2024, 31 Mar. 2028, 24K15743

  対象リソースIRI