Researcher Profile and Settings

Researcher

• Name

  Tokumasu Fuyuki

Profile and Settings

• Name

  Tokumasu, Fuyuki

Alternate Names

• Fuyuki Tokumasu

Affiliation

• Gunma University, Graduate School of Health Science Laboratory Science, Professor

Education

• 1996, 2000, Kyoto University, Human and Environmental Studies
• 1994, 1996, The Ohio State University, Biophysics Interdisciplinary Program
• Aug. 1990, May 1994, Birmingham-Southern College, Physics

Degree

• Ph.D., Kyoto University, 2000
• Master of Science, The Ohio State University
• Bachelor of Science, Birmingham-Southern College, 1994

Association Memberships

• American Society of Cell Biology
• Biophysical Society
• THE JAPANESE SOCIETY OF PARASITOLOGY
• THE JAPANESE BIOCHEMICAL SOCIETY

Research Experience

• 01 Apr. 2024, 31 Mar. 2025, Prof lv, Japan
• Apr. 2024, 9999
• Apr. 2019, 9999, Department of Lipidomics, School of Medicine, The University of Tokyo
• Apr. 2014, 9999, National Center for Global Health and Medicine
• Apr. 2019, Mar. 2024, School of Tropical Medicine and Global Health, Nagasaki University, Professor
• Apr. 2019, Mar. 2024, Institute of Tropical Medicine, Nagasaki University, Department of Cellular Architecture Studies, Shionogi Global Infectious Diseases Division, Professor
• Apr. 2014, Mar. 2019, The University of Tokyo
• 2006, Mar. 2014, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Staff Scientist
• 2007, 2014, NIAD, NIH, Biophysical and Biochemical Parasitology Project, Leading Investigator
• 2003, 2013, National Institute of Standards and Technology, Guest Researcher
• 2003, 2006, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Research Fellow
• 2001, 2003, National Institutes of Health, National Institute of Allergy and Infectious Diseases, JSPS-NIH Research Fellow
• 2000, 2001, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Visiting Fellow

Research Activities

Research Areas

• Life sciences, Parasitology
• Natural sciences, Bio-, chemical, and soft-matter physics
• Life sciences, Biophysics

Research Interests

• Fluorescence Microscopy
• Atomic force Microscopy
• Lipid membrane
• Malaria
• Biophysics

Published Papers

• Discovery of antimalarial drugs from secondary metabolites in actinomycetes culture library., Teklemichael, A. A., Teshima, A., Hirata, A., Akimoto, M., Taniguchi, M., Khodakaramian, G., Fujimura, T., Tokumasu, F.., Arakawa, K. & Mizukami, S., 09 Jul. 2024, Tropical Medicine and Health, 52, 1, 11, Scientific journal

  DOI
• Hyperspectral analysis to assess gametocytogenesis stage progression in malaria-infected human erythrocytes, Ik Hwan Kwon, Ji Youn Lee, Fuyuki Tokumasu, Sang-Won Lee, Jeeseong Hwang, 24 Jan. 2025, Journal of Biomedical Optics, 30, 2, 023516-1, 023516-14, Scientific journal

  DOI
• Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization, Junpei Fukumoto, Minako Yoshida, Suzumi M. Tokuoka, Eri Saki H. Hayakawa, Shinya Miyazaki, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Jiro Usukura, Hideo Shindou & Fuyuki Tokumasu, 29 Jan. 2025, Communications Biology, 8, 142, 1, 17, Scientific journal

  DOI
• Different lateral packing stress in acyl chains alters KcsA orientation and structure in lipid membranes, Eri Saki H Hayakawa, Misuzu Ueki, Elmukhtar Alhatmi, Shigetoshi Oiki, Fuyuki Tokumasu, Drake C Mitchell, Masayuki Iwamoto, 18 May 2025, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866, 6, 1, 10, Scientific journal

  DOI
• Pivotal roles ofPlasmodium falciparumlysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization, Junpei Fukumoto; Minako Yoshida; Suzumi M. Tokuoka; Eri Saki H. Hayakawa; Shinya Miyazaki; Takaya Sakura; Daniel Ken Inaoka; Kiyoshi Kita; Jiro Usukura; Hideo Shindou; Fuyuki Tokumasu, 13 Jan. 2024

  DOI
• Effect of geranylated dihydrochalcone from Artocarpus altilis leaves extract on Plasmodium falciparum ultrastructural changes and mitochondrial malate: Quinone oxidoreductase, Agriana Rosmalina Hidayati; Melinda; Hilkatul Ilmi; Takaya Sakura; Miako Sakaguchi; Junko Ohmori; Endah Dwi Hartuti; Lidya Tumewu; Daniel Ken Inaoka; Mulyadi Tanjung; Eri Yoshida; Fuyuki Tokumasu; Kiyoshi Kita; Mihoko Mori; Kazuyuki Dobashi; Tomoyoshi Nozaki; Din Syafruddin; Achmad Fuad Hafid; Danang Waluyo; Aty Widyawaruyanti, Apr. 2023, International Journal for Parasitology: Drugs and Drug Resistance, 21, 40, 50, Scientific journal

  DOI
• Budding pouches and associated bubbles: 3D visualization of exo-membrane structures in plasmodium falciparum gametocytes, Eri Saki H. Hayakawa; Marina Wayama; Fuyuki Tokumasu; Nobuhiko Ohno; Mami Matsumoto; Jiro Usukura, 22 Aug. 2022, Frontiers in Cellular and Infection Microbiology, 12, Scientific journal

  DOI
• Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins, Naoyuki Iso-o; Keisuke Komatsuya; Fuyuki Tokumasu; Noriko Isoo; Tomohiro Ishigaki; Hiroshi Yasui; Hiroshi Yotsuyanagi; Masumi Hara; Kiyoshi Kita, 11 Nov. 2021, Frontiers in Cell and Developmental Biology, 9, 1, 12, Scientific journal

  DOI
• Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase, Endah Dwi Hartuti; Takaya Sakura; Mohammed S. O. Tagod; Eri Yoshida; Xinying Wang; Kota Mochizuki; Rajib Acharjee; Yuichi Matsuo; Fuyuki Tokumasu; Mihoko Mori; Danang Waluyo; Kazuro Shiomi; Tomoyoshi Nozaki; Shinjiro Hamano; Tomoo Shiba; Kiyoshi Kita; Daniel Ken Inaoka, 05 Jul. 2021, International Journal of Molecular Sciences, 22, 13, 7236, 7236, Scientific journal

  DOI
• Creative interior design by Plasmodium falciparum: Lipid metabolism and the parasite's secret chamber., Fuyuki Tokumasu; Eri H Hayakawa; Junpei Fukumoto; Suzumi M Tokuoka; Shinya Miyazaki, 24 Apr. 2021, Parasitology international, 83, 102369, 102369, Scientific journal

  DOI
• Polyunsaturated fatty acids promote Plasmodium falciparum gametocytogenesis, Takeshi Q Tanaka; Suzumi M Tokuoka; Daichi Nakatani; Fumie Hamano; Shin-ichiro Kawazu; Thomas E Wellems; Kiyoshi Kita; Takao Shimizu; Fuyuki Tokumasu, Jul. 2019, Biology Open, 8, 7, bio042259, Scientific journal

  DOI
• Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity, Emmanuel Oluwadare Balogun; Daniel Ken Inaoka; Tomoo Shiba; Suzumi M. Tokuoka; Fuyuki Tokumasu; Kimitoshi Sakamoto; Yasutoshi Kido; Paul A. M. Michels; Yoh-Ichi Watanabe; Shigeharu Harada; Kiyoshi Kita, Nov. 2017, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1861, 11, 2830, 2842, Scientific journal

  DOI
• Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells, Hideo Shindou; Hideto Koso; Junko Sasaki; Hiroki Nakanishi; Hiroshi Sagara; Koh M. Nakagawa; Yoshikazu Takahashi; Daisuke Hishikawa; Yoshiko Iizuka-Hishikawa; Fuyuki Tokumasu; Hiroshi Noguchi; Sumiko Watanabe; Takehiko Sasaki; Takao Shimizu, Jul. 2017, JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 29, 12054, 12064, Scientific journal

  DOI
• Digital phantoms generated by spectral and spatial light modulators, Bonghwan Chon; Fuyuki Tokumasu; Ji Youn Lee; David W. Allen; Joseph P. Rice; Jeeseong Hwang, 01 Nov. 2015, Journal of Biomedical Optics, 20, 11, 111215, 111218, Scientific journal

  DOI
• Imaging of the subsurface structures of "unroofed" Plasmodium falciparum-infected erythrocytes, Eri H. Hayakawa; Fuyuki Tokumasu; Jiro Usukura; Hiroyuki Matsuoka; Takafumi Tsuboi; Thomas E. Wellems, Jun. 2015, EXPERIMENTAL PARASITOLOGY, 153, 174, 179, Scientific journal

  DOI
• Accumulations and Energy Recycling Pathway in P. Falciparum Gametocyte-Infected Human Erythrocytes, Fuyuki Tokumasu; Takeshi Q. Tanaka; Suzumi Tokuoka; Daichi Nakatani; Shin-ichiro Kawazu; Kiyoshi Kita, Jan. 2015, BIOPHYSICAL JOURNAL, 108, 2, 614A, 614A, Symposium

  DOI
• Simplagrin, a Platelet Aggregation Inhibitor from Simulium nigrimanum Salivary Glands Specifically Binds to the Von Willebrand Factor Receptor in Collagen and Inhibits Carotid Thrombus Formation In Vivo, Andrezza C. Chagas; Peter McPhie; Hong San; David Narum; Karine Reiter; Fuyuki Tokumasu; Fabio A. Brayner; Luiz C. Alves; José M. C. Ribeiro; Eric Calvo, 12 Jun. 2014, PLoS Neglected Tropical Diseases, 8, 6, e2947, e2947, Scientific journal

  DOI
• Inward cholesterol gradient of the membrane system in P. falciparum-infected erythrocytes involves a dilution effect from parasite-produced lipids, Fuyuki Tokumasu; Georgeta Crivat; Hans Ackerman; Jeeseong Hwang; Thomas E. Wellems, Jun. 2014, BIOLOGY OPEN, 3, 6, 529, 541, Scientific journal

  DOI
• Modifications in erythrocyte membrane zeta potential by Plasmodium falciparum infection, Fuyuki Tokumasu; Graciela R. Ostera; Chanaki Amaratunga; Rick M. Fairhurst, Jun. 2012, EXPERIMENTAL PARASITOLOGY, 131, 2, 245, 251, Scientific journal

  DOI
• Absorption-based hyperspectral imaging and analysis of single erythrocytes, Lee, J.Y.; Clarke, M.L.; Tokumasu, F.; Lesoine, J.F.; Allen, D.W.; Chang, R.; Litorja, M.; Hwang, J., May 2012, IEEE Journal on Selected Topics in Quantum Electronics, 18, 3, 1130, 1139, Scientific journal

  DOI
• Tetracysteine-Based Fluorescent Tags to Study Protein Localization and Trafficking in Plasmodium falciparum-Infected Erythrocytes, Georgeta Crivat; Fuyuki Tokumasu; Juliana Martha Sa; Jeeseong Hwang; Thomas E. Wellems, Aug. 2011, PLOS ONE, 6, 8, Scientific journal

  DOI
• A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets alpha(IIb)beta(3) or alpha(V)beta(3) and inhibits platelet aggregation and angiogenesis, Dongying Ma; Xueqing Xu; Su An; Huan Liu; Xuening Yang; John F. Andersen; Yipeng Wang; Fuyuki Tokumasu; Jose M. C. Ribeiro; Ivo M. B. Francischetti; Ren Lai, Jun. 2011, THROMBOSIS AND HAEMOSTASIS, 105, 6, 1032, 1045, Scientific journal

  DOI
• Plasmodium falciparum: Nitric oxide modulates heme speciation in isolated food vacuoles, Graciela Ostera; Fuyuki Tokumasu; Clarissa Teixeira; Nicolas Collin; Juliana Sa; Jennifer Hume; Sanjai Kumar; Jose Ribeiro; Gudrun S. Lukat-Rodgers; Kenton R. Rodgers, Jan. 2011, EXPERIMENTAL PARASITOLOGY, 127, 1, 1, 8, Scientific journal

  DOI
• Aegyptin displays high-affinity for the von Willebrand factor binding site (RGQOGVMGF) in collagen and inhibits carotid thrombus formation in vivo, Eric Calvo; Fuyuki Tokumasu; Daniella M. Mizurini; Peter McPhie; David L. Narum; Jose Marcos C. Ribeiro; Robson Q. Monteiro; Ivo M. B. Francischetti, Jan. 2010, FEBS JOURNAL, 277, 2, 413, 427, Scientific journal

  DOI
• Probing dynamic fluorescence properties of single and clustered quantum dots toward quantitative biomedical imaging of cells, Hyeong-Gon Kang; Fuyuki Tokumasu; Matthew Clarke; Zhenping Zhou; Jianyong Tang; Tinh Nguyen; Jeeseong Hwang, Jan. 2010, WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2, 1, 48, 58, Scientific journal

  DOI
• Altered Membrane Structure and Surface Potential in Homozygous Hemoglobin C Erythrocytes, Fuyuki Tokumasu; Glenn A. Nardone; Graciela R. Ostera; Rick M. Fairhurst; Steven D. Beaudry; Eri Hayakawa; James A. Dvorak, Jun. 2009, PLOS ONE, 4, 6, e5828, Scientific journal

  DOI
• Plasmodium falciparum: Food vacuole localization of nitric oxide-derived species in intraerythrocytic stages of the malaria parasite, Graciela Ostera; Fuyuki Tokumasu; Fabiano Oliveira; Juliana Sa; Tetsuya Furuya; Clarissa Teixeira; James Dvorak, Sep. 2008, EXPERIMENTAL PARASITOLOGY, 120, 1, 29, 38, Scientific journal

  DOI
• A Mycobacterium tuberculosis-derived lipid inhibits membrane fusion by modulating lipid membrane domains, Eri Hayakawa; Fuyuki Tokumasu; Glenn A. Nardone; Albert J. Jin; Vince A. Hackley; James A. Dvorak, Dec. 2007, BIOPHYSICAL JOURNAL, 93, 11, 4018, 4030, Scientific journal

  DOI
• Aegyptin, a novel mosquito salivary gland protein, specifically binds to collagen and prevents its interaction with platelet glycoprotein VI, integrin alpha 2 beta 1, and von Willebrand factor, Eric Calvo; Fuyuki Tokumasu; Osvaldo Marinotti; Jean-Luc Villeval; Jose M. C. Ribeiro; Ivo M. B. Francischetti, Sep. 2007, JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 37, 26928, 26938, Scientific journal

  DOI
• Band 3 modifications in Plasmodium falciparum-infected AA and CC erythrocytes assayed by autocorrelation analysis using quantum dots, F Tokumasu; RM Fairhurst; GR Ostera; NJ Brittain; J Hwang; TE Wellems; JA Dvorak, Mar. 2005, JOURNAL OF CELL SCIENCE, 118, 5, 1091, 1098, Scientific journal

  DOI
• Heterogeneous molecular distribution in supported multicomponent lipid bilayers, F Tokumasu; J Hwang; JA Dvorak, Feb. 2004, LANGMUIR, 20, 3, 614, 618, Scientific journal

  DOI
• Atomic force microscopy of nanometric liposome adsorption and nanoscopic membrane domain formation, F Tokumasu; AJ Jin; GW Feigenson; JA Dvorak, Oct. 2003, ULTRAMICROSCOPY, 97, 1-4, 217, 227, Scientific journal

  DOI
• Development and application of quantum dots for immunocytochemistry of human erythrocytes, F Tokumasu; J Dvorak, Sep. 2003, JOURNAL OF MICROSCOPY-OXFORD, 211, Pt3, 256, 261, Scientific journal
• Nanoscopic lipid domain dynamics revealed by atomic force microscopy, F Tokumasu; AJ Jin; GW Feigenson; JA Dvorak, Apr. 2003, BIOPHYSICAL JOURNAL, 84, 4, 2609, 2618, Scientific journal

  DOI
• Lipid membrane phase behaviour elucidated in real time by controlled environment atomic force microscopy, F Tokumasu; AJ Jin; JA Dvorak, 2002, JOURNAL OF ELECTRON MICROSCOPY, 51, 1, 1, 9, Scientific journal

  DOI
• Long range interaction of cis-DNA elements mediated by architectural transcription factor Bach1, Yoshida, C.; Tokumasu, F.; Hohmura, K.I.; Bungert, J.; Hayashi, N.; Nagasawa, T.; Engel, J.D.; Yamamoto, M.; Takeyasu, K.; Igarashi, K., Nov. 1999, Genes to Cells, 4, 11, 643, 655, Scientific journal

  DOI
• Atomic force microscopy sees nucleosome positioning and histone H1-induced compaction in reconstituted chromatin, Sato, M.H.; Ura, K.; Hohmura, K.I.; Tokumasu, F.; Yoshimura, S.H.; Hanaoka, F.; Takeyasu, K., 11 Jun. 1999, FEBS Letters, 452, 3, 267, 271, Scientific journal

  DOI
• Carbon nanotube tips for a scanning probe microscope: their fabrication and properties, S Akita; H Nishijima; Y Nakayama; F Tokumasu; K Takeyasu, May 1999, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 32, 9, 1044, 1048, Scientific journal

  DOI
• Plasmid relaxation and DNA shortening induced by DNA-replication initiating proteins, F Tokumasu; SH Yoshimura; M Sato; F Matsunaga; H Uga; C Wada; K Takeyasu, Feb. 1998, BIOPHYSICAL JOURNAL, 74, 2, A287, A287
• Atomic force microscopy of Escherichia coli FoF1-ATPase in reconstituted membranes, Takeyasu, K.; Omote, H.; Nettikadan, S.; Tokumasu, F.; Iwamoto-Kihara, A.; Futai, M., Nov. 1997, Annals of the New York Academy of Sciences, 834, 1 Na/K-ATPase a, 149, 152, Scientific journal

  DOI
• [Atomic force microscopy for biochemist], Tokumasu F; Takeyasu K, Jun. 1997, Scientific journal
• Atomic force microscopy for biochemist, Tokumasu, F.; Takeyasu, K., 1997, Seikagaku, 69, 6, Scientific journal
• Atomic force microscopy proposes a novel model for stem-loop structure that binds a heat shock protein in the Staphylococcus aureus HSP70 operon, Ohta, T.; Nettikadan, S.; Tokumasu, F.; Ideno, H.; Abe, Y.; Kuroda, M.; Hayashi, H.; Takeyasu, K., Sep. 1996, Biochemical and Biophysical Research Communications, 226, 3, 730, 734, Scientific journal

  DOI
• Quantitative Analysis of the Transcription Factor AP2 Binding to DNA by Atomic Force Microscopy, Saju Nettikadan; Fuyuki Tokumasu; Kunio Takeyasu, Sep. 1996, Biochemical and Biophysical Research Communications, 226, 3, 645, 649, Scientific journal

  DOI
• Molecular imaging of Escherichia coli F0F1-ATPase in reconstituted membranes using atomic force microscopy, Takeyasu, K.; Omote, H.; Nettikadan, S.; Tokumasu, F.; Iwamoto-Kihara, A.; Futai, M., 1996, FEBS Letters, 392, 2, Scientific journal

  DOI

MISC

• 赤内型マラリア原虫はエクソソームを介して宿主血小板由来スカベンジャー受容体CD36を輸送され宿主HDLを取り込む, 磯尾 直之; 小松谷 啓介; 徳舛 富由樹; 原 眞純; 北 潔, Jun. 2018, 50回, 279, 279
• 細胞外リン脂質は熱帯熱マラリア原虫性分化の重要因子である, 田中 健; 徳岡 涼美; 中谷 大地; 浜野 文三江; Wellems Thomas; 河津 信一郎; 北 潔; 清水 孝雄; 徳舛 富由樹, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [3LBA, 106]
• 熱帯熱マラリア原虫による細胞外Glycerolのリン脂質生成への取り込み, 徳舛富由樹; 徳岡涼美; 田中健Q; 稲岡健ダニエル; 浜野文三江; 河津信一郎; 北潔; 清水孝雄; 清水孝雄, Sep. 2016, 日本生化学会大会(Web), 89th, ROMBUNNO.1T16‐03(1P‐352) (WEB ONLY), 03(1P
• 熱帯マラリア原虫ガメトサイト内リン脂質・中性脂質プロファイルの解析, 田中健Q; 徳岡涼美; 中谷大地; 河津信一郎; 浜野文三江; 北潔; 清水孝雄; 清水孝雄; 徳舛富由樹, Feb. 2016, 日本寄生虫学会大会プログラム・抄録集, 85th, 64
• 熱帯熱マラリア原虫ガメトサイトの脂質分子プロファイルの解析, 田中健; 徳岡涼美; 中谷大地; 浜野文三江; 浜野文三江; 河津信一郎; 北潔; 清水孝雄; 清水孝雄; 徳舛富由樹, Dec. 2015, 日本生化学会大会(Web), 88th, 2P0371 (WEB ONLY), [2P0371]
• 熱帯熱マラリア原虫ガメトサイト内の脂質分子代謝と糖新生経路の解析, 徳舛富由樹; 田中健; 徳岡涼美; 中谷大地; 河津信一郎; 北潔, Feb. 2015, 日本寄生虫学会大会プログラム・抄録集, 84th, 76
• The Steric Fine Structure of Maurer's Cleft in "Unroofed" Plasmodium Falciparum-Infected Erythrocytes, Eri H. Hayakawa; Fuyuki Tokumasu; Jiro Usukura; Hiroyuki Matsuoka; Takafumi Tsuboi; Thomas E. Wellems, Jan. 2015, BIOPHYSICAL JOURNAL, 108, 2, 618A, 618A, Summary international conference
• Three dimensional structure of Maurer's cleft with tiny filaments in Plasmodium falciparum-infected Erythrocytes by "unroofing" method, E. H. Hayakawa; F. Tokumasu; J. Usukura; H. Matsuoka; T. Tsuboi; T. E. Wellems, Dec. 2014, MOLECULAR BIOLOGY OF THE CELL, 25, Summary international conference
• 熱帯マラリア原虫ガメトサイト期における脂質分子の蓄積とエネルギー再利用経路の解析, 徳舛富由樹; 田中健Q; 徳岡涼美; 中谷大地; 河津信一郎; 北潔, Oct. 2014, 日本生化学会大会(Web), 87th, 3P-482 (WEB ONLY), 482]
• Label-Free Hyperspectral Imaging of Intracellular Hemoglobin in Human Erythrocytes, Ji Youn Lee; Fuyuki Tokumasu; Dan Sackett; Ralph Nossal; Jeeseong Hwang, Jan. 2012, BIOPHYSICAL JOURNAL, 102, 3, 195A, 195A, Summary international conference
• Three Dimensional Imaging of Maurer's Clefts in "Unroofed" Plasmodium Falciparum-Infected Erythrocytes by Transmission Electron Microscopy, Eri H. Hayakawa; Fuyuki Tokumasu; Jiro Usukura; Takafumi Tsuboi; Hiroyuki Matsuoka; Thomas E. Wellems, Jan. 2012, BIOPHYSICAL JOURNAL, 102, 3, 395A, 395A, Summary international conference
• Stereoscopic transmission electron microscopy of Maurer's Clefts in "unroofed" specimens of Plasmodium falciparum-infected erythrocytes, E. H. Hayakawa; F. Tokumasu; J. Usukura; T. Tuboi; H. Matsuoka; T. E. Wellems, 2011, MOLECULAR BIOLOGY OF THE CELL, 22, Summary international conference
• ASSOCIATION OF NITRIC OXIDE WITH HEME IN PLASMODIUM FALCIPARUM FOOD VACUOLES, Graciela R. Ostera; Gudrun Lukat-Rodgers; Fuyuki Tokumasu; Sanjai Kumar; Kenton Rodgers, Nov. 2009, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 81, 5, 243, 243, Summary international conference
• The effect of lipoarabinomannan, Mycobacterium tuberculosis - derived lipids on lipid membrane domain structure, E Hayakawa; F Tokumasu; T Takeuchi; JA Dvorak, Jan. 2005, BIOPHYSICAL JOURNAL, 88, 1, 417A, 418A, Summary international conference
• Accelerated band 3 clustering in Plasmodium falciparum-infected homozygous hemoglobin C erythrocytes assayed by single-cell antocorrelation analysis using quantum dots, F Tokumasu; RM Fairhurst; N Brittain; TE Wellems; JA Dvorak, Nov. 2004, MOLECULAR BIOLOGY OF THE CELL, 15, 465A, 465A, Summary international conference
• Lipoarabinomannan, a Mycobacterium tuberculosis-derived lipid modulates raft-like membrane domain structure, E Hayakawa; F Tokumasu; T Takeuchi; JA Dvorak, Nov. 2004, MOLECULAR BIOLOGY OF THE CELL, 15, 318A, 318A, Summary international conference
• Photoluminescence studies of CdSe nanocrystals conjugated with biomolecules., JS Hwang; Krogmeier, JR; F Tokumasu; KA Briggman; JA Dvorak, Jan. 2004, BIOPHYSICAL JOURNAL, 86, 1, 481A, 482A, Summary international conference
• The application of quantum dots for immunocytochemical studies of normal and malaria-infected erythrocytes, F Tokumasu; JA Dvorak, Jan. 2004, BIOPHYSICAL JOURNAL, 86, 1, 581A, 581A, Summary international conference
• Characterization of micro-domain structure in ROS disk model membranes using differential scanning calorimetry and atomic force microscopy, SL Niu; F Tokumasu; A Jin; J Dvorak; BJ Litman, Feb. 2003, BIOPHYSICAL JOURNAL, 84, 2, 332A, 332A, Summary international conference
• Nanoscopic lipid domain dynamics revealed by Atomic Force Microscopy., F Tokumasu; AJ Jin; GW Feigenson; JA Dvorak, Jan. 2002, BIOPHYSICAL JOURNAL, 82, 1, 157A, 157A, Summary international conference
• Atomic force microscopy studies of membrane structure and transformation thermodynamics, F Tokumasu; AJ Jin; JA Dvorak, Jan. 2001, BIOPHYSICAL JOURNAL, 80, 1, 304A, 304A, Summary international conference
• Application of atomic force microscopy to study DNA-protein interactions, S Nettikadan; H Yu; F Tokumasu; P Kolattukudy; K Takeyasu, Feb. 1996, BIOPHYSICAL JOURNAL, 70, 2, TU462, TU462, Summary international conference

Books etc

• 実験医学別冊「脂質解析ハンドブック」脂質分子の正しい理解と取り扱い・データ取得の技術, Joint work, Sep. 2019, 未定, Scholarly book, ISBN: 9784758122412

Presentations

• Study of control mechanisms involved in cell multiplication and sexual differentiation by phospholipid metabolism in Plasmodium falciparum, Fuyuki Tokumasu, The 97th Annual Meeting of the Japanese Biochemical Society, 06 Nov. 2024, 06 Nov. 2024, 08 Nov. 2024, English, Japan
• ハイパースペクトラルイメージングによる熱帯熱マラリアガメトサイトステージ進行の解析, 徳舛富由樹, 第３０回 分子寄生虫学ワークショップ 第２０回 分子寄生虫・マラリア研究フォーラム 合同大会, 29 Aug. 2024, 27 Aug. 2024, 30 Aug. 2024, Japanese, Domestic conference
• マラリア感染赤血球の「構造と状態」を観察する壁を打ち破る, 第 83 回日本寄生虫学会東日本支部大会・ 第 75 回日本衛生動物学会東日本支部大会 合同大会, 12 Oct. 2024, 12 Oct. 2024, 13 Oct. 2024, Japanese, Japan, Domestic conference
• マラリア原虫感染細胞の構造バランスと創薬の可能性, 徳舛富由樹, 第71回北関東医学会総会, 20 Sep. 2024, 19 Sep. 2024, 20 Sep. 2024, Japanese, Domestic conference
• 熱帯熱マラリア原虫（P. falciparum）におけるリン脂質合成経路の解明に向けて, 福本隼平; 吉田益奈子; 宮崎真也; 矢幡一英; 徳舛富由樹, 第92回日本寄生虫学会大会, 31 Mar. 2023, 30 Mar. 2023, 31 Mar. 2023
• P. falciparumにおける細胞内液ー液相分離の解析, 石井隆太; 佐倉孝哉; 稲岡 健ダニエル; 徳舛富由樹, 第92回日本寄生虫学会大会, 31 Mar. 2023, 30 Mar. 2023, 31 Mar. 2023
• リゾフォスファチジン酸アシル転移酵素（LPAAT)は赤内期における熱帯熱マラリア原虫（P. falciparum) のステージ移行に必須である, 福本隼平; 吉田益奈子; 宮崎真也; 矢幡一英; 徳舛富由樹, 第92回日本寄生虫学会大会, 31 Mar. 2023, 30 Mar. 2023, 31 Mar. 2023
• マラリア感染赤血球におけるHDL取り込み関連分子の解析, 徳舛富由樹, 第28回分子寄生虫ワークショップ、第18回分子寄生虫・マラリア研究フォーラム合同大会, 05 Aug. 2022, 03 Aug. 2022, 05 Aug. 2022
• マラリア原虫によるホスト受容体を利用した細胞外コレステロールの取り込み, 徳舛富由樹, 第91回寄生虫学会大会, 29 May 2022, 28 May 2022, 29 May 2022
• Importance of Lipid Biology in Plasmodium falciparum development and differentiation, Fuyuki Tokumasu, The 18th Awaji International Forum on Infection and Immunity, 11 Sep. 2019, English, International conference
• マラリア原虫感染細胞の脂質Variationに関わる代謝系の解析, 徳舛富由樹, 第27回分子寄生虫ワークショップ、第17回分子寄生虫・マラリア研究フォーラム合同大会, 29 Aug. 2019, Japanese, Domestic conference
• ネズミマラリア原虫Plasmodium yoeliiのDiacylglycerol kinase (DAGK)は赤血球進入関連分子の表面分泌に関わる, 石崎隆弘, 第27回分子寄生虫ワークショップ、第17回分子寄生虫・マラリア研究フォーラム合同大会, 28 Aug. 2019, Japanese, Domestic conference
• Elucidation of biosynthesis of very long chain fatty acids in the protozoan pathogenEntamoeba histolytica, Santos Herbert J, 第88回日本寄生虫学会大会, 17 Mar. 2019, English, Domestic conference
• Red cells become good home for malaria parasites, Fuyuki Tokumasu, Tropical Diseases II, International Health Study, The University of Tokyo, 19 Jan. 2019, English
• Characterizations of Lysophospholipid Acyltransferase in Plasmodium falciparum, Fuyuki Tokumasu, The 26th Molecular parasitology workshop/The 16th Molecular parasitology and malaria research forum, 19 Sep. 2018, English, Domestic conference
• Layered membrane structure and 3D environment created in Plasmodium falciparum-infected erythrocyte, 徳舛富由樹, 生化学特別講義 (岡山大学医歯薬学総合研究科）Methods in Science Research (Basics and Applications), 06 Mar. 2017, Japanese
• マラリア原虫による ホスト赤血球膜改変と3 次元的環境構築, 徳舛富由樹, 日本脂質生化学会 ランチョンセミナー, 09 Jun. 2016, Japanese, Domestic conference
• Phospholipid and Neutral Lipid Profile Analyses of Plasmodium falciparum gametocyte, Fuyuki Tokumasu, The 85th Annual Meeting of the Japanese Society of Parasitology, 20 Mar. 2016, English, Domestic conference
• Host membrane modifications and establishment of 3D intracellular environment by malaria parasite, Fuyuki Tokumasu, プロテオサイエンスセンター学術シンポジウム, 13 Feb. 2016, Japanese, Domestic conference
• Lipid profile study of Plasmodium falciparum gametocytes, Fuyuki Tokumasu, The 23nd Molecular parasitology workshop/The 13th Molecular parasitology and malaria research forum, 30 Aug. 2015, Japanese, Domestic conference
• Lipid metabolism and gluconeogenesis in Plasmodium falciparum gametocytes, Fuyuki Tokumasu, The 84th Annual Meeting of the Japanese Society of Parasitology, 21 Mar. 2015, Japanese, Domestic conference
• Host membrane modifications and inward cholesterol gradient occurred in malaria parasite-infected human erythrocytes, Fuyuki Tokumasu, The 35th International Plant Meeting in Kyoto, 16 Jan. 2015, English, International conference
• Lipid membrane modifications in malaria parasite-infected human erythrocytes., Fuyuki Tokumasu, The 22nd Molecular parasitology workshop/The 12th Molecular parasitology and malaria research forum, 31 Aug. 2014, Japanese, Domestic conference
• Unique membrane modifications in Plasmodium falciparum-infected HbS erythrocytes revealed by fluorescence lifetime microscopy, Fuyuki Tokumasu, The 82th Annual Meeting of the Japanese Society of Parasitology, 29 Mar. 2013, Japanese, Domestic conference
• Membrane properties of Plasmodium falciparum-infected erythrocytes revealed by Fluorescence Lifetime Microscopy, Fuyuki Tokumasu, The 81th Annual Meeting of the Japanese Society of Parasitology, 22 Mar. 2012, Japanese, Domestic conference
• Pathophysiology and Public Health of Dengue, Fuyuki Tokumasu, Georgetown University Public Health Program, Nov. 2011, English
• Three world infectious diseases, Fuyuki Tokumasu, 宇部教会公開セミナー, 27 Jul. 2005, Japanese
• Molecular Assembly of Biological Macromolecules Studied by Atomic Force Microscopy : Quantitative analyses of membrane structures and DNA-protein interactions., Fuyuki Tokumasu, 12th Symposium on Analytical Chemistry of Biological Samples, 1997, English, Domestic conference

Research Projects

• Apr. 2023, Mar. 2025, Principal investigator, 23K06518
• Apr. 2017, Mar. 2020, Principal investigator, Competitive research funding

  対象リソースIRI
• Apr. 2015, Principal investigator, Competitive research funding
• Biochemical And Biophysical Parasitology (#1ZIAAI000099), Fuyuki Tokumasu, National Institutes of Health, Investigator-Initiated Intramural Research Projects (ZIA), National Institute of Allergy and Infectious Diseases, Sep. 2007, Aug. 2014, Principal investigator

Educational Activities

Teaching Experience

• 01 Oct. 2024
• 01 Oct. 2024, Undergraduate special subjects, Japan
• Apr. 2024, 9999
• Apr. 2024, 9999
• Apr. 2024, 9999
• Oct. 2019, Mar. 2024
• Global Health Seminar, Nagasaki University, May 2022, Aug. 2022

Social Contribution

Media Coverage

• マラリアの新規創薬を目指した新展開, 05 Jul. 2024, Media report
• 长崎大学发现维系疟原虫生存的脂质分子群的合成酶，通过基因破坏可使原虫灭亡, Other than myself, Internet

  共同研究・競争的資金等の業績ID
• Nagasaki University identifies enzyme required for synthesizing lipid molecules critical for survival of malaria parasite, Other than myself, Science Japan, 16 Apr. 2025, "Medicine" section, Internet, On February 14, a research group led by Professor Daniel Ken Inaoka of the Department of Molecular Infection Dynamics, Institute of Tropical Medicine at Nagasaki University, Research Fellow Junpei Fukumoto of the Proteo-Science Center at Ehime University, and Professor Fuyuki Tokumasu of the Graduate School of Health Sciences at Gunma University, in collaboration with the National Center for Global Health and Medicine and Jichi Medical University, has announced that they have identified an acyltransferase (PfLPLAT1) essential for the survival of Plasmodium falciparum. P. falciparum rapidly died when the gene for this enzyme was destroyed. The findings are expected to contribute to the development of new antimalarial drugs and were published in the international journal Communications Biology on January 29.

  共同研究・競争的資金等の業績ID
• マラリアの新規創薬を目指した新展開, Myself, 05 Jul. 2024, Media report