Researcher Profile and Settings

Researcher

• Name

  SAHEKI Toshihiko

Profile and Settings

• Name

  Saheki, Toshihiko

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Assistant of Professor

Degree

• Ph.D

Association Memberships

• JAPAN SOCIETY FOR SCIENCE EDUCATION
• JAPAN SOCIETY FOR SCIENCE EDUCATION

Research Experience

• 1991, 1992
• 2005, 2007
• Gunma University, Assistant Professor, Assistant prof lv

Research Activities

Research Areas

• Life sciences, Molecular biology
• Life sciences, Cell biology
• Life sciences, Functional biochemistry

Research Interests

• Polyploid
• Hepatocyte
• Cytokinesis
• Intermediate filaments
• Cytoskeleton
• signal transduction
• proteomics
• stem cell
• regeneration
• differentiation

Published Papers

• STRUCTURE OF THE BOVINE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR (TYPE-C) GENE, T SAHEKI,T MIZUNO,T IWATA,Y SAITO,T NAGASAWA,KU MIZUNO,F ITO,T ITO,H HAGIWARA,S HIROSE, Jun. 1991, JOURNAL OF BIOLOGICAL CHEMISTRY, 266, 17, 11122, 11125, Scientific journal
• OROTATE PHOSPHORIBOSYLTRANSFERASE FROM THERMUS-THERMOPHILUS - OVEREXPRESSION IN ESCHERICHIA-COLI, PURIFICATION AND CHARACTERIZATION, J BUNNAK,H HAMANA,Y OGINO,T SAHEKI,A YAMAGISHI,T OSHIMA,T DATE,T SHINOZAWA, Dec. 1995, JOURNAL OF BIOCHEMISTRY, 118, 6, 1261, 1267, Scientific journal
• REGULATION FACTOR FOR PLANARIAN REGENERATION, T SHINOZAWA,S SHIOZAKI,M EZAKI,H FUJINO,T TANAKA,T SAHEKI, Jun. 1995, HYDROBIOLOGIA, 305, 1-3, 247, 253, Scientific journal
• PHYSICAL AND FUNCTIONAL ASSOCIATION OF THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR WITH PARTICULATE GUANYLATE-CYCLASE AS DEMONSTRATED USING DETERGENT EXTRACTS OF BOVINE LUNG MEMBRANES, M ISHIDO,T FUJITA,H HAGIWARA,M SHIMONAKA,T SAHEKI,Y HIRATA,S HIROSE, Oct. 1986, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 140, 1, 101, 106, Scientific journal
• IDENTIFICATION OF THE PRIMARY TRANSLATION PRODUCT OF ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR MESSENGER-RNA IN A CELL-FREE SYSTEM USING ANTIRECEPTOR ANTISERUM, K UCHIDA,M SHIMONAKA,T SAHEKI,T ITO,S HIROSE, Sep. 1987, JOURNAL OF BIOLOGICAL CHEMISTRY, 262, 26, 12401, 12402
• INHIBITION OF ATRIAL NATRIURETIC PEPTIDE-INDUCED CYCLIC-GMP ACCUMULATION IN THE BOVINE ENDOTHELIAL-CELLS WITH ANTI-ATRIAL NATRIURETIC PEPTIDE RECEPTOR ANTISERUM, M ISHIDO,T FUJITA,M SHIMONAKA,T SAHEKI,S OHUCHI,T KUME,ISHIGAKI\, I,S HIROSE, Jan. 1989, JOURNAL OF BIOLOGICAL CHEMISTRY, 264, 1, 641, 645, Scientific journal
• IMMUNOCHEMICAL AND BIOCHEMICAL DISTINCTION OF SUBTYPES OF ATRIAL NATRIURETIC PEPTIDE RECEPTOR, T SAHEKI,M SHIMONAKA,K UCHIDA,T MIZUNO,S HIROSE, Oct. 1989, JOURNAL OF BIOCHEMISTRY, 106, 4, 627, 632, Scientific journal
• PRIMARY STRUCTURE OF THE HUMAN ELAFIN PRECURSOR PREPROELAFIN DEDUCED FROM THE NUCLEOTIDE-SEQUENCE OF ITS GENE AND THE PRESENCE OF UNIQUE REPETITIVE SEQUENCES IN THE PROSEGMENT, T SAHEKI,F ITO,H HAGIWARA,Y SAITO,J KUROKI,S TACHIBANA,S HIROSE, May 1992, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 185, 1, 240, 245, Scientific journal
• 畜産副生物、特に家畜肺の高度利用−家畜肺からの ANP 受容体の単離とそのサブタイプの同定−, 内田恵子,佐伯 俊彦,水野 武,萩原啓実,広瀬茂久, 1989, 7, 461, 466
• コンニャク飛粉中の神経活性化物質（抗うつ、抗痴呆物質）の実用化研究, 関口昭博,佐伯俊彦,鎌田 直, 2008, 7, 4, 9, 12
• Triple Helical Conformation in Aqueous Solutions of β-1,3-D-Glucans with Varyling the Degree of Branching by the Smigh Degradation, Yoshiba Kazuto,Saheki Toshihiko,Christensen Gjorn E,Dobashi Toshiaki, 2019, ACS Applied Bio Materials
• 細胞の運命を操るために, 佐伯俊彦, 2006, 科技振セミナー講演集
• Carcinogen adsorbent prepared from DNA complex by gamma-ray irradiation, 2008, Journal of Biomaterials Science: Polymer Edition
• 組換えセリシンの大腸菌での発現とその性質, 佐伯 俊彦, 2004, 3, 4, 13, 14
• 血圧調節にかかわるペプチド因子の構造とその作用機態(中) ナトリウム利尿ペプチドの作用機序, 萩原啓実,佐伯俊彦,広瀬茂久, 1992, 8, 258, 263
• Induction of PC12 Cell Death, Apoptosis, by a Sialoglycopeptide from Bovine Brain., Kobayashi\, Y,Saheki\, T,Shinozawa\, T, 1994, Biochem. Biophys. Res. Commun., 203, 1554, 1559
• Visualization of ANP Receptor on Glomeruli of Bovine Kidney by Use of a Specific Antiserum., Shimonaka\, M,Saheki\, T,Hagiwara\, H,Hagiwara\, Y,Sono\, H,Hirose\, S, 1987, Am. J. Physiol., 253, F1058, F1062
• Purification of Atrial Natriuretic Peptide Receptor from Bovine Lung., Shimonaka\, M,Saheki\, T,Hagiwara\, H,Ishido\, M,Nogi\, A,Fujita\, T,Wakita\, K,Inada\, Y,Kondo\, J,Hirose\, S, 1987, J. Biol. Chem., 262, 12, 5510, 5514
• Miniaturized two-dimensional gel electrophoresis of high-molecular-weight proteins using low-concentration multifilament-supporting gel for isoelectric focusing, ODAKE Tamao;SAHEKI Toshihiko;KAMEZAWA Kazutoshi;MIYATA Kozue;TAKIGUCHI Hiromi;HOTTA Hiroki;ONDA Koki;KOJIMA Yasuaki;LI Jinxiang;TSUNODA Kin-ichi, Dec. 2009, Journal of Electrophoresis, 53, 4, 57, 61
• The Student Exchange Program Between Gunma University and New York State University at Stony Brock, SAHEKI Toshihiko, 2015, Journal of JSEE, 63, 5, 5_117, 5_121
• Fast separation of large proteins with two-dimensional gel electrophoresis using a low-concentration polyacrylamide gel supported by a loose multifilament string, Saheki Toshihiko;Odake Tamao;Kojima Yasuaki;Tsunoda Kin-ichi, 2005, Abstracts for Annual Meeting of Japanese Proteomics Society, 2005, 0, 95, 95
• Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation., Saheki Toshihiko;Ito Hitomi;Sekiguchi Akihiro;Nishina Atsuyoshi;Sugiyama Toshihiro;Izumi Takashi;Kojima Itaru, 15 Jan. 2008, Cytotechnology, 57, 2

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test., Enomoto Rina;Kurosawa Aya;Nikaido Yoshiaki;Mashiko Misaki;Saheki Toshihiko;Nakajima Nozomi;Kuroiwa Satoshi;Otobe Michinari;Ohsaki Maki;Tooyama Kazuya;Inoue Yusuke;Kuwabara Nobuo;Kikuchi Osamu;Kitamura Tadahiro;Kojima Itaru;Nakagawa Yuko;Saito Tamio;Osada Hiroyuki;Futahashi Mizuko;Sezutsu Hideki;Takeda Shigeki, 17 Aug. 2017, European journal of pharmacology, 814

  DOI
• Conformation and cooperative order-disorder transition in aqueous solutions of β-1,3-d-glucan with different degree of branching varied by the Smith degradation., Yoshiba Kazuto;Saheki Toshihiko;Christensen Bjørn E;Dobashi Toshiaki, 10 Jun. 2019, Biopolymers, 110, 9

  DOI
• ヒストン脱アセチル化酵素阻害剤を用いた多核細胞誘導時のp53 mRNA発現量の減少はインスリンにより回復する, ;, Nov. 2022, 95回, 2P

MISC

• Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation, Toshihiko Saheki,Hitomi Ito,Akihiro Sekiguchi,Atsuyoshi Nishina,Toshihiro Sugiyama,Takashi Izumi,Itaru Kojima, Jun. 2008, CYTOTECHNOLOGY, 57, 2, 137, 143

  DOI
• A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test, Rina Enomoto,Aya Kurosawa,Yoshiaki Nikaido,Misaki Mashiko,Toshihiko Saheki,Nozomi Nakajima,Satoshi Kuroiwa,Michinari Otobe,Maki Ohsaki,Kazuya Tooyama,Yusuke Inoue,Nobuo Kuwabara,Osamu Kikuchi,Tadahiro Kitamura,Itaru Kojima,Yuko Nakagawa,Tamio Saito,Hiroyuki Osada,Mizuko Futahashi,Hideki Sezutsu,Shigeki Takeda, Nov. 2017, EUROPEAN JOURNAL OF PHARMACOLOGY, 814, 130, 137

  DOI
• Miniaturized two-dimensional gel electrophoresis of high-molecular-weight proteins using low-concentration multifilament-supporting gel for isoelectric focusing, Odake T,Saheki T,Kamezawa K,Miyata K,Takiguchi H,Hotta H,Onda K,Kojima Y,Li J,Tsunoda K, 2010, J. Electrophoresis, 53, 57, 61

  DOI
• Study of butyrate signal transduction pathways in rat hepatic stem-like cells, Saheki T,Mukai Y,Saito K,Tajima E,Katakura K,Nishina A,Kishi M,Izumi T,Sugiyama T,Kojima I, 2009, Animal Cell Technol.: Basic & Applied Aspects, Proceedings of the 21st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT), 16
• Genomic and proteomic characterization of the large Myoviridae bacteriophage: PHAGE TMA of the extreme thermophile Thermus thermophilus., Tamakoshi M,Murakami A,Tsuneizumi K,Sugisawa M,Kodama M,Takeda S,Saheki T,Izumi T,Akiba T,Mitsuoka K,Toh H,Yamashita A,Arisaka F,Hattori M,Oshima T,Yamagishi A, 2011, 1, 152, 164
• Additive Effects of Betains on the Fibrinogen cryogelation Induced by Low Temperature, Y. Toyama,K. Miyamoto,K. Kubota,K. Wakamatsu,N. Nameki,T. Saheki,M. Ochiai, 2011, Transactions of the Materials Research Society of Japan, 36, 3, 393, 396

  DOI
• Miniaturized two-dimensional gel electrophoresis of high-molecular-weight proteins using low-concentration multifilament-supporting gel for isoelectric focusing, Odake T,Saheki T,Kamezawa K,Miyata K,Takiguchi H,Hotta H,Onda K,Kojima Y,Li J,Tsunoda K, 2010, 53, 57, 61

  DOI
• Study of butyrate signal transduction pathways in rat hepatic stem-like cells, Saheki T,Mukai Y,Saito K,Tajima E,Katakura K,Nishina A,Kishi M,Izumi T,Sugiyama T,Kojima I, 2009, 16
• Genomic and proteomic characterization of the large Myoviridae bacteriophage: PHAGE TMA of the extreme thermophile Thermus thermophilus., Tamakoshi M,Murakami A,Tsuneizumi K,Sugisawa M,Kodama M,Takeda S,Saheki T,Izumi T,Akiba T,Mitsuoka K,Toh H,Yamashita A,Arisaka F,Hattori M,Oshima T,Yamagishi A, 2011, 1, 152, 164
• 群馬大学とニューヨーク州立大学ストーニーブルック校との交換留学プログラム, 佐伯俊彦, 2015, 63, 5, 117, 121
• 理工学部サマープログラム２０１４の開催について, 佐伯 俊彦, 2014, 14, 1, 29, 32

Books etc

• Leap to the Future! 1 (2022), Contributor, Mutsumi Iijima, Are you not Good at English?, 31 Mar. 2021, 124, 60-63, Textbook
• Leap to the Future! 2 (2022), Contributor, Mutsumi Iijima, Are you not Good at English?, 31 Mar. 2021, 124, 60-63, Textbook

Presentations

• Insulin restores decreased p53 mRNA expression during polynucleated cells induction using a histone deacetylase inhibitor, Haruka Kimura, Toshihiko Saheki, The 95th Annual Meeting of the Japanease Biochemical Society, 10 Nov. 2022, 09 Nov. 2022, 11 Nov. 2022
• Insulin affects p21 expression to promote polynuclear rat hepatic stem-like cell induction by histone deacetylase inhibitor, Toshihiko Saheki, Haruka Kimura, The 74th Annual Meeting of the Japan Society for Cell Biology, 28 Jun. 2022, 28 Jun. 2022, 30 Jun. 2022
• ヒストン脱アセチル化酵素阻害剤による多核細胞誘導はインスリンで促進される, 木村春香、佐伯俊彦, 日本化学会関東支部群馬地区研究交流会, 04 Dec. 2021, 04 Dec. 2021, 04 Dec. 2021, Japanese, Japan, Domestic conference
• ラット肝臓幹様細胞の多核化における中間径フィラメントビメンチンのリン酸化, 佐伯 俊彦,福島 惇斗,髙梨 有輝, 第92回日本生化学会大会, 20 Sep. 2019, English, Domestic conference
• 中間径フィラメントビメンチンとラット肝臓幹様細胞の多核化との関連, 佐伯 俊彦,登坂 凌雅,髙梨 有輝,福島 惇斗, 第71回日本細胞生物学会年会, 24 Jun. 2019, English, Domestic conference
• Acquisition of multiple nuclei by sodium butyrate treatment of rat hepatic stem-like cells, The Molecular Biology Society of Japan, 2011
• Proteomic analysis of polyploid cells derived from rat hepatic stem-like cells, The Japanese Biochemical Society, 2013
• Analysis of histone H3 acetylation in rat hepatic stem-like cells during multiple nucleation, Japanese Association for Animal Cell Technology, 2012
• 酪酸ナトリウムに対して可逆的に反応するラット肝臓幹様細胞のプロテオーム解析, 日本分子生物学会, 2009
• 電場中で低濃度のポリアクリルアミドゲルが変形する要因の解明, 日本バイオレオロジー学会, 2009
• マイタケ由来のリゾホスファチジルエタノールアミン（ＬＰＥ）を添加したPC12細胞中のモノアミン含量の経時変化, 日本農芸化学会, 2009
• 酪酸ナトリウムでラット肝臓幹様細胞のAnnexin A3 の発現が抑制される, 日本生化学会, 2010
• ラット肝臓幹様細胞の多核化, 日本動物細胞工学会2011年大会, 2011
• Acquisition of multiple nuclei by sodium butyrate treatment of rat hepatic stem-like cells, The Molecular Biology Society of Japan, 2011
• ラット肝臓幹様細胞から誘導された多核細胞の性質, 日本生化学会, 2012
• ラット肝臓幹様細胞から誘導された多核細胞の性質, 日本動物細胞工学会, 2012
• ラット肝臓幹様細胞の多核化機構と細胞活性の解析, 日本動物細胞工学会, 2013
• Proteomic analysis of polyploid cells derived from rat hepatic stem-like cells, The Japanese Biochemical Society, 2013
• ラット肝臓幹様細胞の多核化におけるアクチンの役割, 日本生化学会, 2014
• ヒストン脱アセチル化酵素阻害剤はラット肝臓幹様細胞を多核細胞に誘導する, 日本細胞生物学会, 2015
• ヒストン脱アセチル化酵素阻害剤が細胞質分裂不全を引き起こしラット肝臓幹様細胞を多核にする, 日本生化学会, 2015
• ラット肝臓幹様細胞を使った多核細胞形成のモデル実験系, 日本細胞生物学会, 2014
• 3-ヒドロキシ酪酸がラット肝臓肝様細胞を多核化する, 第69回 日本細胞生物学会, 2017
• Analysis of histone H3 acetylation in rat hepatic stem-like cells during multiple nucleation, Japanese Association for Animal Cell Technology, 2012
• 肝臓由来細胞が多核化する細胞質分裂のポイントは複数存在する, 佐伯 俊彦,髙梨 有輝, 第72回日本細胞生物学会年会, 09 Jun. 2020, 09 Jun. 2020, 11 Jun. 2020, English, Domestic conference
• TD-NMRによるポリアクリルアミドゲルの分析, 福島 惇斗,佐伯 俊彦, 2019年日本化学会関東支部群馬地区研究交流発表会, 07 Dec. 2019, 07 Dec. 2019, 07 Dec. 2019, Japanese, Japan, Domestic conference
• 自作ステージヒーターを用いた細胞分裂のタイムラプス観察, 高梨有輝, 佐伯 俊彦, 2019年日本化学会関東支部群馬地区研究交流発表会, 07 Dec. 2019, 07 Dec. 2019, 07 Dec. 2019, Japanese, Japan, Domestic conference

Research Grants & Projects

• 20211207, 20220331

Social Contribution

Social Contribution

• 第95回群馬県創意くふう作品展　審査委員, 2410, 2410, Others　(Target:　Schoolchildren, Junior high school students, High school students, General)
• 高校生サイエンスインストラクター育成プログラム, 2408, 2408, Seminar　(Target:　High school students)
• サイエンスインストラクター養成講座, 21 Sep. 2020, 22 Sep. 2020, Seminar　(Target:　High school students)
• 桐生高校スーパーサイエンスハイスクール, 2018, Research advise　(Target:　High school students)
• 桐生高校スーパーサイエンスハイスクール, 2019, Research advise　(Target:　High school students)
• 桐生高校スーパーサイエンスハイスクール, 2020, Research advise　(Target:　High school students)
• 桐生高校スーパーサイエンスハイスクール, 2021, Research advise　(Target:　High school students)
• サイエンスインストラクター養成講座, 21 Sep. 2019, 22 Sep. 2019, Seminar　(Target:　High school students)
• サイエンスインストラクター養成講座, 22 Nov. 2020, 22 Nov. 2020, Seminar　(Target:　High school students)
• 高校生サイエンスインストラクター育成プログラム, 22 Aug. 2022, 23 Aug. 2020, Seminar　(Target:　High school students)
• 高校生サイエンスインストラクター育成プログラム, 09 Oct. 2022, 10 Oct. 2020, Seminar　(Target:　High school students)
• 高校生サイエンスインストラクター育成プログラム, 22 Aug. 2023, 23 Aug. 2023, Seminar　(Target:　High school students)
• 高校生サイエンスインストラクター育成プログラム, 22 Sep. 2023, 22 Sep. 2023, Seminar　(Target:　High school students)