Researcher Profile and Settings

Researcher

• Name

  SANO Takaaki

Affiliation

• Diagnostic Pathology, Associate Professor

Profile and Settings

• Name

  Sano, Takaaki

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Gunma University, Associate Professor
• Gunma University, Associate Professor

Affiliation

• Affiliation

  Graduate School of Medicine, Diagnostic Pathology

Degree

• Doctor(Medical Science)
• Doctor(Medical Science)
• Doctor(Medical Science)
• Doctor(Medical Science)
• Doctor(Medical Science), Gunma University

Research Activities

Research Areas

• Life sciences, Human pathology

Research Interests

• Diagnastic pathology
• Human papillomavirus

Published Papers

• A case of pneumatosis cystoides intestinalis with intra-abdominal free air developed during treatment with voglibose, Hisanaga E, Sano T, Kumakura Y, Yokoyama Y, Nakajima I, Takagi H, Jun. 2022, JGH Open, 6, 643, 646, Scientific journal
• 核内にグリコーゲンの封入体様構造が目立った卵巣明細胞癌の１例, 吉田玲佳、佐野孝昭、星川里美、栗原康哲、伊古田勇人, Sep. 2022, 61, 333, 338, Scientific journal
• Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor with next-generation sequencing cancer panel analysis: A case report, Seki-Soda M, Sano T, Matsumura N, Takayama Y, Gomi A, Ogawa M, Yokoo S, Oyama T, 2022, Oral Surg Oral Med Oral Pathol Oral Radiol, 134, e58, e65, Scientific journal
• Multimodal immunotherapy ameliorates myasthenia gravis preceded by thymoma-associated multiorgan autoimmunity, Kasahara H, Shimizu K, Makioka K, Sano T, Ohtaki Y, Ikeda Y, 2022, Immunologic Research, Scientific journal
• Mesenteric phlebosclerosis associated with the oral intake of Japanese traditional (Kampo) medicines containing Gardeniae Fructus: A case report, Hisanaga E, Sano T, Sato K, Kuribayashi S, Uraoka T., Oct. 2021, Clin J Gastroenterol, 14, 1453, 1458, Scientific journal
• CD15+ tumor infiltrating granulocytic cells can predict recurrence and their depletion is accompanied by good responses to S-1 with oral cancer, Seki-Soda M, Sano T, Ogawa M, Yokoo S,Oyama T, Aug. 2021, Head Neck, 43, 8, 2457, 2467
• A mucinous cystic neoplasm of the pancreas containing an undifferentiated carcinoma component and harboring the NRAS driver mutation, Hisanaga E, Sano T, Yoshida Y, Ishii N, Shirabe K, Ikota H, Jun. 2021, Clinical journal of gastroenterology, 14, 910, 917
• Adenocarcinoma with intraductal papillary mucinous neoplasm arising in a duodenal heterotopic pancreas: a case report., Etsuko Hisanaga; Takaaki Sano; Norio Kubo; Norihiro Ishii; Ken Shirabe; Hitoshi Takagi; Junko Hirato; Hayato Ikota, 10 Sep. 2020, Clinical journal of gastroenterology, 13, 6, 1373, 1382, Scientific journal

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• Liver metastasis from papillary thyroid carcinoma treated by laparoscopic hepatectomy 43 years after resection of the primary tumor: a case report., Mariko Tsukagoshi; Norifumi Harimoto; Kenichiro Araki; Norio Kubo; Akira Watanabe; Takamichi Igarashi; Norihiro Ishii; Toshiki Yajima; Takaaki Sano; Ken Shirabe, 18 Jun. 2020, Surgical case reports, 6, 1, 142, 142, Scientific journal

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• Diagnostic value of 18F-FDG-PET to predict the tumour immune status defined by tumoural PD-L1 and CD8+tumour-infiltrating lymphocytes in oral squamous cell carcinoma., Maria Togo; Takehiko Yokobori; Kimihiro Shimizu; Tadashi Handa; Kyoichi Kaira; Takaaki Sano; Mariko Tsukagoshi; Tetsuya Higuchi; Satoshi Yokoo; Ken Shirabe; Tetsunari Oyama, 02 Apr. 2020, British journal of cancer, 122, 11, 1686, 1694, Scientific journal

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• Human papillomavirus (HPV) 56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの1例, 下田雄輝、佐野孝昭、村上千明、岩科雅範、松山敏之、近松一朗、小山徹也, Apr. 2020, 37, 168, 175
• 傍糸球体細胞腫2例の臨床・病理学的検討, 久永悦子、佐野孝昭、新井基展、野村昌史、鈴木和浩、伊古田勇人, Apr. 2020, 37, 136, 141
• An immunohistochemical and genetic study of BRAFV600E mutation in Japanese patients with ameloblastoma., Mai Seki-Soda; Takaaki Sano; Kenta Ito; Satoshi Yokoo; Tetsunari Oyama, Apr. 2020, Pathology international, 70, 4, 224, 230, Scientific journal

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• Two cases of odontogenic carcinoma with sclerosing features in the mandible: Diagnostic difficulties in a sclerosing odontogenic carcinoma, Mai Seki-Soda; Takaaki Sano; Ikuko Ogawa; Ayataka Ishikawa; Hideo Arai; Junko Hirato; Yu Takayama; Satoshi Yokoo; Takashi Takata; Tetsunari Oyama, Mar. 2020, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32, 2, 149, 155, Scientific journal

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• Histopathological changes in tumor budding between biopsy and resected specimens from patients treated with preoperative S‐1 chemotherapy for oral cancer, Mai Seki-Soda; Takaaki Sano; Hiromi Koshi; Satoshi Yokoo; Tetsunari Oyama, Nov. 2019, Journal of Oral Pathology & Medicine, 48, 10, 880, 887, Scientific journal

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• Granulocyte colony-stimulating factor(G-CSF)産生乳癌の1例, 片山 彩香; 平方 智子; 孫 莉華; 尾林 紗弥香; 黒住 献; 藤井 孝明; 佐野 孝昭; 飯野 祐一; 小山 徹也, Jul. 2019, 27, 47, 52
• びまん性特発性神経内分泌過形成を背景に発生した定型カルチノイドの1切除例, 河谷 菜津子; 清水 公裕; 中澤 世識; 尾林 海; 伊部 崇史; 矢島 俊樹; 茂木 晃; 調 憲; 片山 彩香; 佐野 孝昭; 小山 徹也, Apr. 2019, 59, 2, 185, 186
• 発症後22年以上の長期生存を認めた肺類上皮血管内皮腫の1例, 越 浩美; 佐野 孝昭; 原 健一郎; 早田 麻衣; 小山 徹也, Jul. 2018, 診断病理, 35, 3, 210, 215
• High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma, Yuki Shimoda; Yasunari Ubukata; Tadashi Handa; Takehiko Yokobori; Takayoshi Watanabe; Dolgormaa Gantumur; Kei Hagiwara; Takahiro Yamanaka; Mariko Tsukagoshi; Takamichi Igarashi; Akira Watanabe; Norio Kubo; Kenichiro Araki; Norifumi Harimoto; Ayaka Katayama; Toshiaki Hikino; Takaaki Sano; Kyoichi Ogata; Hiroyuki Kuwano; Ken Shirabe; Tetsunari Oyama, 25 May 2018, BMC Cancer, 18, 1, Scientific journal

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• 甲状腺に病変を形成したランゲルハンス細胞組織球症の1例, 竹渕 友弥; 佐野 孝昭; 後藤 優典; 星川 里美; 栗原 康哲; 伊古田 勇人; 平戸 純子; 小山 徹也, May 2018, 日本臨床細胞学会雑誌, 57, 3, 177, 182
• Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses, Hideo Arai; Sumihito Nobusawa; Reika Kawabata-Iwakawa; Susumu Rokudai; Toru Higuchi; Tatsuya Yamazaki; Jun Horiguchi; Takaaki Sano; Masaru Kojima; Masahiko Nishiyama; Hideaki Yokoo; Junko Hirato; Tetsunari Oyama, 01 Apr. 2018, British Journal of Haematology, 181, 2, 255, 259

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• Diagnostic pitfalls in malignant effusion cytology: Report of a case with breast cancer recurrence 28 years after surgery, Ishida Akane; Saito Makoto; Nagase Taihei; Arai Hideo; Ikota Hayato; Sano Takaaki; Hirato Junko; Sakurai Shinji, Nov. 2017, 日本臨床細胞学会雑誌, 56, 6, 289, 296
• Tumour budding evaluated in biopsy specimens is a useful predictor of prognosis in patients with cN0 early stage oral squamous cell carcinoma, Mai Seki; Takaaki Sano; Satoshi Yokoo; Tetsunari Oyama, May 2017, HISTOPATHOLOGY, 70, 6, 869, 879, Scientific journal

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• 簡易遺伝子変異測定機器(i-densy、IS-5320)を用いたIDH1の遺伝子変異検索, 越 浩美; 加藤 潤一; 半田 正; 佐野 孝昭; 小山 徹也, May 2017, 臨床病理, 65, 5, 520, 525
• Histologic assessment of tumor budding in preoperative biopsies to predict nodal metastasis in squamous cell carcinoma of the tongue and floor of the mouth, Mai Seki; Takaaki Sano; Satoshi Yokoo; Tetsunari Oyama, Apr. 2016, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38, E1582, E1590, Scientific journal

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• Immunocytochemical analysis of p63 and 34E12 in fine needle aspiration cytology specimens for breast lesions: a potentially useful discriminatory marker between intraductal papilloma and ductal carcinoma in situ, S. Hoshikawa; T. Sano; J. Hirato; T. Oyama; T. Fukuda, Apr. 2016, CYTOPATHOLOGY, 27, 2, 108, 114, Scientific journal

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• L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors, Hiromi Koshi; Takaaki Sano; Tadashi Handa; Takashi Yanagawa; Kenichi Saitou; Shushi Nagamori; Yoshikatsu Kanai; Kenji Takagishi; Tetsunari Oyama, Sep. 2015, PATHOLOGY INTERNATIONAL, 65, 9, 460, 467, Scientific journal

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• Spindle cell lipoma of the tongue: Two case reports, Mai Seki; Takaaki Sano; Satoshi Yokoo; Tetsunari Oyama, 01 Jul. 2015, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27, 4, 595, 600, Scientific journal

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• Solitary fibrous tumor composing benign and malignant components in the floor of the mouth: A case report, Aiko Nobusawa; Akihide Negishi; Takaaki Sano; Junko Hirato; Tetsunari Oyama; Satoshi Yokoo, 01 Mar. 2015, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27, 2, 267, 270, Scientific journal

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• Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis, Yasuo Shimizu; Kunio Dobashi; Hiroyuki Nagase; Ken Ohta; Takaaki Sano; Shinichi Matsuzaki; Yoshiki Ishii; Takahiro Satoh; Masashi Koka; Akihito Yokoyama; Takeru Ohkubo; Yasuyuki Ishii; Tomihiro Kamiya, Jan. 2015, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 56, 1, 74, 83, Scientific journal

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• Stratified mucin-producing intraepithelial lesions (SMILEs) of the uterine cervix are associated with HPV integration, Takaaki Sano; Chiharu Nakamura; Tomomi Yoshida; Tetsunari Oyama, Dec. 2014, PATHOLOGY INTERNATIONAL, 64, 12, 628, 630

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• Ameloblastic carcinoma developing in preexisting ameloblastoma with a mutation of the p53 gene: a case report, Aiko Nobusawa; Takaaki Sano; Satoshi Yokoo; Tetsunari Oyama, Nov. 2014, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 118, 5, E146, E150, Scientific journal

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• 【甲状腺疾患診断NOW】 甲状腺穿刺吸引細胞診の最近の動向, 星川 里美; 佐野 孝昭; 栗原 康哲; 吉田 朋美; 福田 利夫; 小山 徹也, Nov. 2014, 臨床検査, 58, 12, 1474, 1479
• Detection of human papillomavirus (HPV) in patients with squamous cell carcinoma and the clinical characteristics of HPV-positive cases, A. Shimizu; M. Kato; Y. Takeuchi; T. Sano; K. Kaira; H. Uezato; O. Ishikawa, Oct. 2014, BRITISH JOURNAL OF DERMATOLOGY, 171, 4, 779, 785, Scientific journal

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• Human Papillomavirus (HPV) infection and immunohistochemistry, Sano, T., 01 Jan. 2014, Kitakanto Medical Journal, 64, 4, 347, 348, Scientific journal

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• Immunohistochemical staining patterns of cytokeratins 13, 14, and 17 in oral epithelial dysplasia including orthokeratotic dysplasia, Aiko Nobusawa; Takaaki Sano; Akihide Negishi; Satoshi Yokoo; Tetsunari Oyama, Jan. 2014, PATHOLOGY INTERNATIONAL, 64, 1, 20, 27, Scientific journal

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• Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer, Hiroki Nakajima; Yuko Ishikawa; Mio Furuya; Takaaki Sano; Yoshihiro Ohno; Jun Horiguchi; Tetsunari Oyama, Jan. 2014, BREAST CANCER, 21, 1, 66, 74, Scientific journal

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• ROCK ACTIVATION IN LUNG OF IDIOPATHIC PULMONARY FIBROSIS WITH OXIDATIVE STRESS, Y. Shimizu; K. Dobashi; T. Sano; M. Yamada, Jan. 2014, INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 27, 1, 37, 44, Scientific journal
• A peculiar squamous dysplastic lesion presenting as a ground-glass opacity: A case report, Jun Atsumi; Kimihiro Shimizu; Tetsuhiro Nakano; Seiichi Kakegawa; Takaaki Sano; Mio Katano; Kenzo Hiroshima; Izumi Takeyoshi, 01 May 2013, European Respiratory Journal, 41, 5, 1228, 1237

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• Gardner症候群に発生したmicrocystic stromal tumor of the ovaryの1例, 越 浩美; 佐野 孝昭; 瀬川 篤記; 井出 宗則; 平戸 純子; 小山 徹也, Jan. 2013, 診断病理, 30, 1, 53, 57
• 甲状腺びまん性硬化型乳頭癌の1例 細胞像・組織像の検討, 西島 良美; 吉田 朋美; 佐野 孝昭; 平戸 純子; 小山 徹也; 福田 利夫, Nov. 2012, 日本臨床細胞学会雑誌, 51, 6, 402, 408
• Bizarre parosteal osteochondromatous proliferation of the maxilla: a case report, Aiko Nobusawa; Takaaki Sano; Akihide Negishi; Satoshi Yokoo; Takehiko Yamaguchi; Tetsunari Oyama, Oct. 2012, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 114, 4, E20, E24, Scientific journal

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• 血性胸腹水と心嚢液貯留および呼吸不全を呈した、びまん性リンパ管腫症の一例, 小板橋 紀通; 稲川 万里江; 大山 善昭; 舘野 利絵子; 倉林 正彦; 井出 宗則; 佐野 孝昭; 中里 洋一, Jul. 2012, 診療と新薬, 49, 7, 966, 970
• Dual Color in Situ Hybridization and Mutational Analysis of Triple Negative Breast Cancer with EGFR Protein Overexpression, H. Nakajima; Y. Ishikawa; Y. Mitani; Y. Ohno; M. Furuya; J. Horiguchi; T. Sano; T. Oyama, Mar. 2012, EUROPEAN JOURNAL OF CANCER, 48, S120, S120
• Paget's disease of bone resembling bone metastasis from gastric cancer, Yasuyuki Shimoyama; Motoyasu Kusano; Yoko Shimoda; Shingo Ishihara; Yoshitaka Toyomasu; Tetsuro Ohno; Erito Mochiki; Takaaki Sano; Junko Hirato; Masatomo Mori, Aug. 2011, Clinical Journal of Gastroenterology, 4, 4, 207, 211, Scientific journal

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• Usefulness of CINtec (R) PLUS p16(INK4a)/Ki-67 Double-Staining in Cytological Screening of Cervical Cancer, Tomomi Yoshida; Takaaki Sano; Tatsuya Kanuma; Hiroshi Inoue; Teruko Itoh; Chiaki Yazaki; Mitsuo Obara; Toshio Fukuda, 2011, ACTA CYTOLOGICA, 55, 5, 413, 420, Scientific journal

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• Comparison of Self-Collected and Clinician-Collected Materials for Cervical Cytology and Human Papillomavirus Genotyping: Analysis by Linear Array Assay, Tomomi Yoshida; Takaaki Sano; Nami Takada; Tatsuya Kanuma; Hiroshi Inoue; Teruko Itoh; Chiaki Yazaki; Mitsuo Obara; Toshio Fukuda, 2011, ACTA CYTOLOGICA, 55, 1, 106, 112, Scientific journal

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• 病理診断に役立つ分子生物学：Human papillomavirus：解説編, 佐野孝昭; 吉田朋美; 福田利夫, 2011, 28(臨時増刊号), 289, 292
• "病理診断に役立つ分子生物学：Human papillomavirus：診断編, 佐野孝昭; 吉田朋美; 福田利夫, 2011, 28(臨時増刊号), 293, 297
• A case of squamous cell carcinoma spreading along the alveolar walls with a ground glass opacity on High Resolution Computed Tomography (HRCT), Jun Atsumi; Kimihiro Shimizu; Seiichi Kakegawa; Takaaki Sano; Mio Katano; Izumi Takeyoshi; Kenzo Hiroshima, Aug. 2010, Japanese Journal of Lung Cancer, 50, 4, 379, 380, Scientific journal

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• CLINICOPATHOLOGICAL AND THERAPEUTIC SIGNIFICANCE OF CXCL12 EXPRESSION IN LUNG CANCER, H. Imai; N. Sunaga; Y. Shimizu; S. Kakegawa; K. Shimizu; T. Sano; T. Ishizuka; T. Oyama; R. Saito; J. D. Minna; M. Mori, Jan. 2010, INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 23, 1, 153, 164, Scientific journal

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• Decreased interstitial FOXP3+ lymphocytes in usual interstitial pneumonia with discrepancy of CXCL12/CXCR4 axis, Yasuo Shimizu; K. Dobashi; K. Endou; A. Ono; N. Yanagitani; M. Utsugi; T. Sano; T. Ishizuka; K. Shimizu; S. Tanaka; M. Mori, 2010, International Journal of Immunopathology and Pharmacology, 23, 2, 449, 461, Scientific journal

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• Immunohistological analysis of HPV L1 capsid protein and p16 protein in low-grade dysplastic lesions of the uterine cervix, Satomi Hoshikawa; Takaaki Sano; Tomomi Yoshida; Hideaki Ito; Tetsunari Oyama; Toshio Fukuda, 2010, PATHOLOGY RESEARCH AND PRACTICE, 206, 12, 816, 820, Scientific journal

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• 肺胞壁に沿って進展する小型肺扁平上皮癌の1例, 片野未央; 佐野孝昭; 中里洋一; 廣島健三; 小山徹也, 2010, 27, 285, 288
• Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma, Tomomi Yoshida; Takaaki Sano; Tetsunari Oyama; Tatsuya Kanuma; Toshio Fukuda, Sep. 2009, VIRCHOWS ARCHIV, 455, 3, 253, 259, Scientific journal

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• Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma, Akihiko Sano; Shinji Sakurai; Hiroyuki Kato; Makoto Sakai; Naritaka Tanaka; Takanori Inose; Kana Saito; Makoto Sohda; Masanobu Nakajima; Kazuha Sakamoto; Takaaki Sano; Yoshinori Hosoya; Takehiko Enomoto; Tatsuo Kanda; Yoichi Ajioka; Tetsunari Oyama; Hiroyuki Kuwano, Aug. 2009, ANTICANCER RESEARCH, 29, 8, 3375, 3380, Scientific journal
• High-grade neuroendocrine carcinoma of the lung: Comparative clinicopathological study of large cell neuroendocrine carcinoma and small cell lung carcinoma, Lihua Sun; Shinji Sakurai; Takaaki Sano; Mitsugu Hironaka; Osamu Kawashima; Takashi Nakajima, Aug. 2009, PATHOLOGY INTERNATIONAL, 59, 8, 522, 529, Scientific journal

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• Aggressive angiomyxoma extending largely into the pelvis: A case report and review of the literature, Kazuhisa Arakawa; Susumu Kawate; Yutaka Sunose; Daisuke Yoshinari; Hiroomi Ogawa; Takaaki Sano; Izumi Takeyoshi, May 2009, Kitakanto Medical Journal, 59, 2, 157, 160, Scientific journal

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• CXCR4(+)FOXP3(+)CD25(+) LYMPHOCYTES ACCUMULATE IN CXCL12-EXPRESSING MALIGNANT PLEURAL MESOTHELIOMA, Y. Shimizu; K. Dobashi; H. Imai; N. Sunaga; A. Ono; T. Sano; T. Hikino; K. Shimizu; S. Tanaka; T. Ishizuka; M. Utsugi; M. Mori, Mar. 2009, INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 22, 1, 43, 51, Scientific journal
• Spacial Distrbution and Content of Asbestos and Metals in Asbestos Lung by In-Air Micro-Particle Induced X-Ray Emission Analysis., K. Dobashi; Y. Shimizu; S. Matsuzaki; T. Kusakabe; T. Nagamine; M. Oikawa; T. Satoh; J. Haga; Y. Ishii; T. Ohkubo; T. Kamiya; K. Arakawa; T. Sano; S. Tanaka; K. Shimizu; M. Utsugi; T. Ishizuka; M. Mori, 2009, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 179
• Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients, Yuqin Li; Yasuo Tanaka; Motohisa Tada; Rui Hua; Motoko Seto; Yoshinari Asaoka; Miki Ohta; Fumihiko Kanai; Haruhiko Yoshida; Takao Kawabe; Takaaki Sano; Teiji Motojima; Osamu Yokosuka; Masao Omata, Oct. 2008, APMIS, 116, 10, 931, 933

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• IN-AIR MICRO-PARTICLE INDUCED X-RAY EMISSION ANALYSIS OF ASBESTOS AND METALS IN LUNG TISSUE, Y. Shimizu; K. Dobashi; T. Kusakbe; T. Nagamine; M. Oikawa; T. Satoh; J. Haga; Y. Ishii; T. Ohkubo; T. Kamiya; K. Arakawa; T. Sano; S. Tanaka; K. Shimizu; S. Matsuzaki; M. Utsugi; M. Mori, Jul. 2008, INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 21, 3, 567, 576, Scientific journal
• Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy, Leri S. Faried; Ahmad Faried; Tatsuya Kanuma; Hiroshi Aoki; Takaaki Sano; Tomoko Nakazato; Tomohiro Tamura; Hiroyuki Kuwano; Takashi Minegishil, Jun. 2008, MOLECULAR CARCINOGENESIS, 47, 6, 446, 457, Scientific journal

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• Immunochemical analysis of HPV L1 capsid protein and p16 protein in liquid-based cytology samples from uterine cervical lesions, Tomolmi Yoshida; Takaaki Sano; Tatsuya Kanuma; Nobuo Owada; Shinji Sakurai; Toshio Fukuda; Takashi Nakajima, Apr. 2008, CANCER CYTOPATHOLOGY, 114, 2, 83, 88, Scientific journal

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• Aberrant methylation status of known methylation-sensitive CpG islands in gastrointestinal stromal tumors without any correlation to the state of c-kit and PDGFRA gene mutations and their malignancy, Kana Saito; Shinji Sakurai; Takaaki Sano; Kazuha Sakamoto; Takayuki Asao; Yoshinori Hosoya; Takashi Nakajima; Hiroyuki Kuwano, Feb. 2008, CANCER SCIENCE, 99, 2, 253, 259, Scientific journal

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• Quantitative real-time polymerase chain reaction analysis of the type distribution, viral load, and physical status of human papillomavirus in liquid-based cytology samples from cervical lesions, T. Yoshida; T. Sano; T. Kanuma; N. Owada; S. Sakurai; T. Fukuda; T. Nakajima, Jan. 2008, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 18, 1, 121, 127, Scientific journal

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• Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis, Gehan Gamal; Takaaki Sano; Shinji Sakurai; Osamu Kawashima; Masayuki Sugano; Takashi Nakajima, Dec. 2007, PATHOLOGY INTERNATIONAL, 57, 12, 765, 774, Scientific journal

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• Gadodiamide投与を確認しえたnephrogenic systemic fibrosis(NSF;腎性全身性線維症)の1例, 対馬 義人; 遠藤 啓吾; 岡部 和彦; 佐野 孝昭, Sep. 2007, 日本透析医学会雑誌, 40, 9, 805, 810
• Nephrogenic systemic fibrosis(NSF:腎性全身性線維症) MRI用造影剤ガドリニウム製剤による新しい副作用, 対馬 義人; 遠藤 啓吾; 佐野 孝昭, Sep. 2007, クリニシアン, 54, 9, 1022, 1031
• CDX2 as a useful marker of colorectal adenocarcinoma metastases to lung in pre-operative biopsy specimens, Shigebumi Tanaka; Kana Saito; Tomokazu Ito; Kohei Tajima; Akira Mogi; Yoshinori Shitara; Takaaki Sano; Hiroyuki Kuwano, Jul. 2007, ONCOLOGY REPORTS, 18, 1, 87, 92, Scientific journal
• Primary omental Gastrointestinal stromal tumor (GIST), Takeshi Todoroki; Takaaki Sano; Shinji Sakurai; Atsuki Segawa; Tamotsu Saitoh; Koichi Fujikawa; Shuji Yamada; Nobutsune Hirahara; Yoshito Tsushima; Ryuji Motojima; Teiji Motojima, 12 Jun. 2007, World Journal of Surgical Oncology, 5, 66, Scientific journal

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• Comparative study using rabbit-derived polyclonal, mouse-derived monoclonal, and rabbit-derived monoclonal antibodies for KIT immunostaining in GIST and other tumors, Masako Saito; Shinji Sakurai; Atsushi Motegi; Kana Saito; Takaaki Sano; Takashi Nakajima, Apr. 2007, PATHOLOGY INTERNATIONAL, 57, 4, 200, 204, Scientific journal

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• 診療に役立つ肉眼像と組織像の理解 マクロからミクロ像を読む(14) 縦隔腫瘍, 田中 司玄文; 佐野 孝昭; 八巻 英; 斉藤 加奈; 桑野 博行, Feb. 2007, 臨床外科, 62, 2, 158, 164
• Clear cell carcinoid tumor of the distal common bile duct, Takeshi Todoroki; Takaaki Sano; Shuji Yamada; Nobutsune Hirahara; Naotaka Toda; Katsuhiko Tsukada; Ryuji Motojima; Teiji Motojima, 2007, World Journal of Surgical Oncology, 5, Scientific journal

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• Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression, Takayuki Kohri; Masayuki Sugano; Osamu Kawashima; Ryusei Saito; Shinji Sakurai; Takaaki Sano; Takashi Nakajima, Dec. 2006, SURGERY TODAY, 36, 12, 1039, 1046, Scientific journal

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• Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy, LS Faried; A Faried; T Kanuma; T Sano; T Nakazato; T Tamura; H Kuwano; T Minegishi, Jul. 2006, ONCOLOGY REPORTS, 16, 1, 57, 63, Scientific journal
• Unique case of pulmonary bronchial gland type tumor with broad spectrum of cell differentiation from the terminal duct-acinar unit to excretory duct, G Gamal; T Nagashima; O Kawashima; M Sugano; S Sakurai; T Sano; T Nakajima, Apr. 2006, PATHOLOGY INTERNATIONAL, 56, 4, 217, 221, Scientific journal

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• Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma, H Nakayama; T Sano; A Motegi; T Oyama; T Nakajima, Nov. 2005, PATHOLOGY INTERNATIONAL, 55, 11, 707, 715, Scientific journal

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• Papillary adenocarcinoma of the lung is a more advanced adenocarcinoma than bronchioloalveolar carcinoma that is composed of two distinct histological subtypes, Z Jian; Y Tomizawa; N Yanagitani; H Iijima; T Sano; T Nakajima, Oct. 2005, PATHOLOGY INTERNATIONAL, 55, 10, 619, 625, Scientific journal

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• A comparison of interobserver reproducibility of gleason grading of prostatic carcinoma in Japan and the United States, T Oyama; WC Allsbrook; K Kurokawa; H Matsuda; A Segawa; T Sano; K Suzuki; JI Epstein, Aug. 2005, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 129, 8, 1004, 1010, Scientific journal
• PKC theta, a novel immunohistochemical marker for gastrointestinal stromal tumors (GIST), especially useful for identifying KIT-negative tumors, A Motegi; S Sakurai; H Nakayama; T Sano; T Oyama; T Nakajima, Mar. 2005, PATHOLOGY INTERNATIONAL, 55, 3, 106, 112, Scientific journal

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• Large cell neuroendocrine carcinoma of the lung: a comparison with large cell carcinoma with neuroendocrine morphology and small cell carcinoma, WX Peng; T Sano; T Oyama; O Kawashima; T Nakajima, Feb. 2005, LUNG CANCER, 47, 2, 225, 233, Scientific journal

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• Pulmonary pleomorphic liposarcoma, Takashi Ibe; Yoshimi Otani; Kimihiro Shimizu; Tetsuhiro Nakano; Takaaki Sano; Yasuo Morishita, 2005, Japanese Journal of Thoracic and Cardiovascular Surgery, 53, 8, 443, 447, Scientific journal

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• Immunohistochemical expression of 14-3-3 sigma protein in various histological subtypes of uterine cervical cancers, T Sano; H Shimooka; P Weixa; A Segawa; Z Jian; A Motegi; H Nakayama; T Oyama; T Nakajima, Oct. 2004, PATHOLOGY INTERNATIONAL, 54, 10, 743, 750, Scientific journal

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• Immunohistochemical analysis of 14-3-3 sigma and related proteins in hyperplastic and neoplastic breast lesions, with particular reference to early carcinogenesis, H Simooka; T Oyama; T Sano; J Horiguchi; T Nakajima, Aug. 2004, PATHOLOGY INTERNATIONAL, 54, 8, 595, 602, Scientific journal

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• Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing - A comparative study using simultaneously sampled histology materials, T Yoshida; T Fukuda; T Sano; T Kanuma; N Owada; T Nakajima, Apr. 2004, CANCER CYTOPATHOLOGY, 102, 2, 100, 108, Scientific journal

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• パピローマウイルス, 佐野 孝昭; 吉田 朋美; 中島 孝, 2004, 22, 292, 297
• Synergistic decline in expressions of p73 and p21 with invasion in esophageal cancers, N Masuda; H Kato; T Nakajima; T Sano; K Kashiwabara; T Oyama; H Kuwano, Jul. 2003, CANCER SCIENCE, 94, 7, 612, 617, Scientific journal

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• Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage, T Nakajima; H Shimooka; WX Peng; A Segawa; A Motegi; J Zhang; N Masuda; M Ide; T Sano; T Oyama; H Tsukagoshi; K Hamanaka; M Maeda, Jun. 2003, PATHOLOGY INTERNATIONAL, 53, 6, 353, 360, Scientific journal

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• 群馬大学医学部附属病院における肺癌剖検例の検討, 郡 隆之; 佐野 孝昭; 小山 徹也; 中島 孝, Jun. 2003, 肺癌, 43, 3, 265, 271
• Interobserver reproducibility of gleason grading of prostate carcinoma, T Oyama; W Allsbrook; K Kurokawa; Y Mikami; A Segawa; T Sano; T Nakajima; K Suzuki; K Mangold; J Epstein, Jan. 2003, LABORATORY INVESTIGATION, 83, 1, 164A, 165A
• Interobserver reproducibility of Gleason grading of prostate carcinoma in Japan, T Oyama; W Allsbrook; K Kurokawa; Y Mikami; A Segawa; T Sano; T Nakjima; K Suzuki; K Mangold; J Epstein, Jan. 2003, MODERN PATHOLOGY, 16, 1, 164A, 165A
• 肺高血圧症と顕微鏡的肺動静脈瘻、肺癌を認めた Osler-Rendu-Weber病の１剖検例, 中山大子; 小山徹也; 中島 孝; 茂木厚; 田嶋久美子; 根岸充子; 張健; 瀬川篤記; 彭為霞; 下岡華子; 佐野 孝昭, 2003, 20, 39, 43
• Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia, T Sano; N Masuda; T Oyama; T Nakajima, May 2002, PATHOLOGY INTERNATIONAL, 52, 5-6, 375, 383, Scientific journal

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• Microcalcifications of breast cancer and atypical cystic lobules associated with infiltration of foam cells expressing osteopontin, T Oyama; T Sano; T Hikino; Q Xue; K Iijima; T Nakajima; F Koerner, Mar. 2002, VIRCHOWS ARCHIV, 440, 3, 267, 273, Scientific journal

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• Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in stage I adenocarcinomas of the lung, Q Xue; T Sano; K Kashiwabara; M Saito; T Oyama; T Nakajima, Feb. 2002, PATHOLOGY INTERNATIONAL, 52, 2, 103, 109, Scientific journal

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• Heal perforation caused by cytomegalovirus infection in a patient with recurrent gastric cancer: Report of a case, S Kawate; S Ohwada; T Sano; Y Kawashima; Kishikawa, I; N Tomizawa; Takeyoshi, I; F Watanuki; Y Morishita, 2002, SURGERY TODAY, 32, 12, 1088, 1090, Scientific journal

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• Activation of cyclin E-dependent kinase activity in colorectal cancer, WR Cam; T Masaki; Y Shiratori; N Kato; M Okamoto; Y Yamaji; K Igarashi; T Sano; M Omata, Oct. 2001, DIGESTIVE DISEASES AND SCIENCES, 46, 10, 2187, 2198, Scientific journal

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• Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma, G Togo; Y Shiratori; M Okamoto; Y Yamaji; M Matsumura; T Sano; T Motojima; M Omata, Aug. 2001, DIGESTIVE DISEASES AND SCIENCES, 46, 8, 1615, 1622, Scientific journal

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• Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum, S Sakurai; T Hishima; Y Takazawa; T Sano; T Nakajima; K Saito; S Morinaga; M Fukayama, Jul. 2001, PATHOLOGY INTERNATIONAL, 51, 7, 524, 531, Scientific journal

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• Reduced C-terminal Src kinase activity is correlated inversely with pp60(c-src) activity in colorectal carcinoma, WR Cam; T Masaki; Y Shiratori; N Kato; T Ikenoue; M Okamoto; K Igarashi; T Sano; M Omata, Jul. 2001, CANCER, 92, 1, 61, 70, Scientific journal

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• Mucinous adenocarcinoma of bartholin eland treated with radiation therapy: a case report, T Ohno; T Nakano; A Abe; T Sano; Y Niibe; K Oka, May 2001, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 31, 5, 226, 230, Scientific journal

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• 直腸肛門部無色素性悪性黒色腫の1例, 角田 祥之; 平山 功; 浅尾 高行; 佐野 孝昭; 中島 孝; 桑野 博行, May 2001, 手術, 55, 5, 733, 736
• Aberrant expression of pRb, p16, p14ARF, MDM2, p21 and p53 in squamous cell carcinomas of lung, Q Xue; T Sano; K Kashiwabara; T Oyama; T Nakajima, Mar. 2001, JAPANESE JOURNAL OF CANCER RESEARCH, 92, 3, 285, 292, Scientific journal
• Mucinous adenocarcinoma of Bartholin gland treated with radiation therapy: A case report, Tatsuya Ohno; Takashi Nakano; Atsuko Abe; Takaaki Sano; Yuzuru Niibe; Kuniyuki Oka, 2001, Japanese Journal of Clinical Oncology, 31, 5, 226, 230, Scientific journal
• A case of esophageal sarcomatoid carcinoma with molecular evidence of a monoclonal origin, K Kashiwabara; T Sano; T Oyama; T Najahima; F Makita; N Hashimoto; K Iwanami; O Kawashima; T Matsumoto; Y Matsuzaki, 2001, PATHOLOGY RESEARCH AND PRACTICE, 197, 1, 41, 46, Scientific journal

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• Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral squamous cell carcinoma, T Sano; T Hikino; Q Xue; T Saito; K Kashiwabara; T Oyama; T Nakajima, Sep. 2000, PATHOLOGY INTERNATIONAL, 50, 9, 709, 716, Scientific journal

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• 組織学的診断が困難であった巨大後腹膜腫瘍の1例, 村田 修; 小林 城治; 伊藤 潤; 伊藤 秀明; 中島 孝; 佐野 孝昭, Feb. 2000, The Kitakanto Medical Journal, 50, 2, 190, 191
• Does mutation of transforming growth factor-beta type II receptor gene play an important role in colorectal polyps?, G Togo; M Okamoto; Y Shiratori; H Yamaji; J Kato; M Matsumura; T Sano; T Motojima; M Omata, Sep. 1999, DIGESTIVE DISEASES AND SCIENCES, 44, 9, 1803, 1809, Scientific journal

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• 胞巣状軟部肉腫の1例 塗抹乾燥標本による結晶構造の観察, 福田 利夫; 斉藤 まさ子; 佐野 孝昭; 柏原 賢治; 小山 徹也; 中島 孝; 篠崎 哲也, Mar. 1999, 日本臨床細胞学会雑誌, 38, 2, 177, 182
• 子宮頚部病変とHPV感染, 佐野 孝昭; 中島 孝, 1999, 17:281
• Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions, T Sano; T Oyama; K Kashiwabara; T Fukuda; T Nakajima, Dec. 1998, AMERICAN JOURNAL OF PATHOLOGY, 153, 6, 1741, 1748, Scientific journal

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• c-Met expression of thyroid tissue with special reference to papillary carcinoma, T Oyama; E Ichimura; T Sano; K Kashiwabara; T Fukuda; T Nakajima, Oct. 1998, PATHOLOGY INTERNATIONAL, 48, 10, 763, 768, Scientific journal

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• Immunohistochemical overexpression of p16 protein associated with intact retinoblastoma protein expression in cervical cancer and cervical intraepithelial neoplasia, T Sano; T Oyama; K Kashiwabara; T Fukuda; T Nakajima, Aug. 1998, PATHOLOGY INTERNATIONAL, 48, 8, 580, 585, Scientific journal

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• Sang T, Hikino T, Niwa Y, Kashiwabara K, Oyama T, Fukuda T, Nakajima T. In situ hybridization with biotinylated tyramide amplification: Detection of human papillomavirus DNA in cervical neoplastic lesions. Mod pathol 1998;11 : 19-23. Reply, T Sano; T Nakajima, Jun. 1998, MODERN PATHOLOGY, 11, 6, 594, 595
• Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non-small cell lung cancers, K Kashiwabara; T Oyama; T Sano; T Fukuda; T Nakajima, Jun. 1998, INTERNATIONAL JOURNAL OF CANCER, 79, 3, 215, 220, Scientific journal

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• In situ hybridization with biotinylated tyramide amplification: Detection of human papillomavirus DNA in cervical neoplastic lesions, T Sano; T Hikino; Y Niwa; K Kashiwabara; T Oyama; T Fukuda; T Nakajima, Jan. 1998, MODERN PATHOLOGY, 11, 1, 19, 23, Scientific journal
• Transitional cell papilloma in the fossa navicularis is positive for human papillomavirus, Nobuaki Shimizu; Yoshio Ichinose; Masamune Shimo; Takaaki Sano; Takashi Nakajima; Hidetoshi Yamanaka, 1998, International Journal of Urology, 5, 3, 296, 298, Scientific journal

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• Coexpression of HGF and c-Met/HGF receptor in human bone and soft tissue tumors, Toshio Fukuda; Eiji Ichimura; Tetsuya Shinozaki; Takaaki Sano; Kenji Kashiwabara; Tetsunari Oyama; Takashi Nakajima; Toshikazu Nakamura, 1998, Pathology International, 48, 10, 757, 762, Scientific journal

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• Why is cyclooxygenase-2 expressed in neuroendocrine cells of the human alimentary tract?, T Nakajima; K Hamanaka; T Fukuda; T Oyama; K Kashiwabara; T Sano, Dec. 1997, PATHOLOGY INTERNATIONAL, 47, 12, 889, 891, Scientific journal

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• GASTRIC ADENOMA - CARCINOMA SEQUENCE WITH SPECIAL REFERENCE TO P53 AND KI-RAS GENE ALTERATIONS, S SAKURAI; T SANO; A MAESHIMA; K KASHIWABARA; T OYAMA; T FUKUDA; T NAKAJIMA, Sep. 1995, VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 427, 2, 119, 124, Scientific journal

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• CLINICOPATHOLOGICAL AND MOLECULAR BIOLOGICAL STUDIES OF GASTRIC ADENOMAS WITH SPECIAL REFERENCE TO P53 ABNORMALITY, S SAKURAI; T SANO; T NAKAJIMA, Jan. 1995, PATHOLOGY INTERNATIONAL, 45, 1, 51, 57, Scientific journal

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• Formalin fixation by boiling: Is it suitable for the TUNEL staining?, Eiji Ichimura; Toshio Fukuda; Tetsunari Oyama; Kenji Kashiwabara; Shinji Sakurai; Takaaki Sano; Takashi Nakajima, 1995, Pathology International, 45, 12, 971, 972

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• Primary malignant lymphoma of the intestine: Clinicopathologic and immunohistochemical studies of 39 cases, Masaru Kojima; Shigeo Nakarnura; Yoshiyuki Kurabayashi; Kazuhiko Shimizu; Yasuo Hosomura; Yoshihiro Ohno; Hideaki Itoh; Katsue Yoshida; Takaaki Sano; Shinji Sakurai; Shigeru Iwasaki; Masato Fujisaki; Taizan Suchi; Takashi Joshita, 1995, Pathology International, 45, 2, 123, 130, Scientific journal

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• Unsuccessful effort to detect human papillomavirus DNA in urinary bladder cancers by the polymerase chain reaction and in situ hybridization, Takaaki Sano; Shinji Sakurai; Toshio Fukuda; Takashi Nakajima, 1995, Pathology International, 45, 7, 506, 512, Scientific journal

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• これだけは知っておきたい検査のポイント パピローマウイルスDNA, 中島 孝; 福田 利夫; 佐野 孝昭, Oct. 1994, Medicina, 31, 11, 500, 502
• ANAPLASTIC LARGE-CELL LYMPHOMA WITH HISTIOCYTIC PHENOTYPES, S SAKURAI; T NAKAJIMA; T OYAMA; T SANO; Y HOSOMURA, Mar. 1993, ACTA PATHOLOGICA JAPONICA, 43, 3, 142, 145, Scientific journal
• Anaplastic large cell lymphoma with histiocytic phenotypes, Shinji Sakurai; Takashi Nakajima; Tetunari Oyama; Takaaki Sano; Yasuo Hosomura, 1993, Pathology International, 43, 3, 142, 145, Scientific journal

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• Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage, NAKAJIMA Takashi;SHIMOOKA Hanako;WEIXA Peng;SEGAWA Atsuki;MOTEGI Atsushi;ZHANG Jian;MASUDA Norihiko;IDE Munenori;SANO Takaaki;OYAMA Tetsunari;TSUKAGOSHI Hiroe;HAMANAKA Kozue;MAEDA Masahiro, Jun. 2003, Pathol. Int., 53, 6, 353, 360
• Multimodal immunotherapy ameliorates myasthenia gravis preceded by thymoma-associated multiorgan autoimmunity., Hiroo Kasahara; Kazuki Shimizu; Kouki Makioka; Takaaki Sano; Yoichi Ohtaki; Yoshio Ikeda, 14 Mar. 2022, Immunologic research, Scientific journal

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• Salvage thoracoscopic esophagectomy after carbon-ion radiotherapy in a patient with esophageal squamous cell carcinoma: a case report., Kengo Kuriyama; Makoto Sohda; Hideyuki Saito; Yasunari Ubukata; Nobuhiro Nakazawa; Keigo Hara; Makoto Sakai; Akihiko Sano; Hiroomi Ogawa; Takaaki Sano; Shigeo Yasuda; Hitoshi Ishikawa; Ken Shirabe; Hiroshi Saeki, 03 Feb. 2022, Surgical case reports, 8, 1, 25, 25, Scientific journal

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• Nuclear morphology in breast lesions: refining its assessment to improve diagnostic concordance., Ayaka Katayama; Michael S Toss; Matthew Parkin; Takaaki Sano; Tetsunari Oyama; Cecily M Quinn; Ian O Ellis; Emad A Rakha, Feb. 2022, Histopathology, 80, 3, 515, 528, Scientific journal

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• Mesenteric phlebosclerosis associated with the oral intake of Japanese traditional (Kampo) medicines containing Gardeniae Fructus., Etsuko Hisanaga; Takaaki Sano; Keigo Sato; Shiko Kuribayashi; Toshio Uraoka, Oct. 2021, Clinical journal of gastroenterology, 14, 5, 1453, 1458, Scientific journal

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• CD15+ tumor infiltrating granulocytic cells can predict recurrence and their depletion is accompanied by good responses to S-1 with oral cancer., Mai Seki-Soda; Takaaki Sano; Masaru Ogawa; Satoshi Yokoo; Tetsunari Oyama, Aug. 2021, Head & neck, 43, 8, 2457, 2467, Scientific journal

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• A mucinous cystic neoplasm of the pancreas containing an undifferentiated carcinoma component and harboring the NRAS driver mutation., Etsuko Hisanaga; Takaaki Sano; Yuka Yoshida; Norihiro Ishii; Ken Shirabe; Hayato Ikota, 12 Mar. 2021, Clinical journal of gastroenterology, Scientific journal

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• 急激な経過で死亡した指状嵌入樹状細胞肉腫の1例, 久永 悦子; 佐野 孝昭; 高山 佳泰; 都丸 翔太; 小林 剛; 平戸 純子; 伊古田 勇人, Oct. 2020, 37, 4, 421, 427
• 傍糸球体細胞腫2例の臨床・病理学的検討, 久永 悦子; 佐野 孝昭; 新井 基展; 野村 昌史; 鈴木 和浩; 伊古田 勇人, Apr. 2020, 37, 2, 136, 141
• Human papillomavirus(HPV)56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの1例, 下田 雄輝; 佐野 孝昭; 村上 千明; 岩科 雅範; 松山 敏之; 近松 一朗; 小山 徹也, Apr. 2020, 37, 2, 168, 175
• Human papillomavirus(HPV)56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの1例, 下田 雄輝; 佐野 孝昭; 村上 千明; 松山 敏之; 小山 徹也, Mar. 2020, 109, 1, 400, 400
• Cover image, Mai Seki-Soda; Takaaki Sano; Hiromi Koshi; Satoshi Yokoo; Tetsunari Oyama, Nov. 2019, Journal of Oral Pathology & Medicine, 48, 10, Scientific journal

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• 気管支ブラシ・気管支洗浄液検体に出現した明細胞肉腫の一例, 竹股 涼; 後藤 優典; 森田 淳; 竹渕 友弥; 星川 里美; 小野里 香織; 栗原 康哲; 佐野 孝昭; 伊古田 勇人, Oct. 2019, 58, Suppl.2, 668, 668
• 顎下腺乳腺相似分泌癌の一例, 森田 淳; 星川 里美; 後藤 優典; 吉田 玲佳; 栗原 康哲; 越 浩美; 佐野 孝昭; 小山 徹也; 伊古田 勇人, Oct. 2019, 58, Suppl.2, 674, 674
• 病理学の教育はこう変わる! バーチャルスライドとMoodleを利用した病理学総論アクティブラーニングの試み, 小山 徹也; 佐野 孝昭; 越 浩美; 早田 麻衣; 片山 彩香; 下田 雄輝, Apr. 2019, 108, 1, 206, 206
• 口腔扁平上皮癌におけるPD-L1発現と18F-FDG集積の関連について, 東郷 真理亜; 横堀 武彦; 半田 正; 佐野 孝昭; 片山 彩香; 下田 雄輝; 清水 公裕; 樋口 徹也; 横尾 聡; 小山 徹也, Apr. 2019, 108, 1, 324, 324
• 早期胃癌の腫瘍免疫に関する臨床病理学的検討, 生方 泰成; 下田 雄輝; 半田 正; 早田 麻衣; 越 浩美; 片山 彩香; 横堀 武彦; 佐野 孝昭; 調 憲; 小山 徹也, Apr. 2019, 108, 1, 371, 371
• 十二指腸に多発ガストリノーマを認めた多発性内分泌腫瘍症1型(MEN1)の一例, 金澤 彩乃; 下田 雄輝; 片山 彩香; 早田 麻衣; 越 浩美; 久保 憲生; 小澤 厚志; 佐野 孝昭; 山田 正信; 小山 徹也, Apr. 2019, 108, 1, 448, 448
• 膵内副脾に発生した類表皮嚢胞の2例, 片山 彩香; 東郷 真理亜; 小松 恵; 下田 雄輝; 伊古田 勇人; 佐野 孝昭; 小山 徹也, Apr. 2018, 107, 1, 366, 366
• Triple negative乳癌におけるCarboxypeptidase A4(CPA4)発現の臨床的意義, 半田 正; 片山 彩香; 横堀 武彦; ゴンボドルジ・ナフチャ; 山根 有人; 川端 麗香; 藤井 孝明; 佐野 孝昭; 西山 正彦; 小山 徹也, Apr. 2018, 107, 1, 429, 429
• Molecular and expressional characterization of tumor heterogeneity in pulmonary carcinosarcoma., Yoichi Ohtaki; Reika Kawabata-Iwakawa; Sumihito Nobusawa; Yusuke Goto; Kimihiro Shimizu; Toshiki Yajima; Seshiru Nakazawa; Natsuko Kawatani; Yuka Yoshida; Takaaki Sano; Ken Shirabe, 18 Jul. 2022, Molecular carcinogenesis, 61, 10, 924, 932, Scientific journal

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• Ghost cell odontogenic carcinoma arising in dentinogenic ghost cell tumor with next-generation sequencing cancer panel analysis: A case report., Mai Seki-Soda; Takaaki Sano; Nozomi Matsumura; Yoshiyasu Takayama; Akinori Gomi; Masaru Ogawa; Satoshi Yokoo; Tetsunari Oyama, 10 Jan. 2022, Oral surgery, oral medicine, oral pathology and oral radiology, 134, 3, e58, e65, Scientific journal

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• A case of nephrogenic systemic fibrosis (NSF) possibly related to gadolinium-based contrast media (Gadodiamide) administration, TSUSHIMA Yoshito; ENDO Keigo; OKABE Kazuhiko; SANO Takaaki, 28 Sep. 2007, Journal of Japanese Society for Dialysis Therapy, 40, 9, 805, 810

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• A CASE OF MYASTHENIA GRAVIS WITH MALIGNANT THYMOMA AND PURE RED CELL APLASIA, FUKUCHI Minoru; NAGAMACHI Yukio; KATOU Hiroyuki; TAKENOSHITA Seiichi; SAKURAI Sinju; SANO Takaaki; NAKAJIMA Takashi, 1994, Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association), 55, 6, 1454, 1459

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• Cover Image, Mai Seki; Takaaki Sano; Emi Saito; Masaru Ogawa; Satoshi Yokoo; Tetsunari Oyama, Feb. 2024, Journal of Oral Pathology & Medicine, Scientific journal

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• Tertiary lymphoid structures in tongue cancer: Association with clinicopathological parameters, preoperative S-1 chemotherapy response, and prognosis., Mai Seki; Takaaki Sano; Emi Saito; Masaru Ogawa; Satoshi Yokoo; Tetsunari Oyama, 06 Jan. 2024, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Scientific journal

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• Relationship between histopathological therapeutic effect and prognosis in oral cancer patients after preoperative S-1 chemotherapy followed by surgery., Mai Seki; Takaaki Sano; Masaru Ogawa; Yu Takayama; Satoshi Yokoo; Tetsunari Oyama, 14 Jun. 2023, Clinical oral investigations, Scientific journal

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• Sigmoid colon schwannoma difficult to distinguish from peritoneal dissemination 13 years after pancreatic neuroendocrine tumor surgery., Kazunobu Suzuki; Takuya Shiraishi; Ikuma Shioi; Naoya Ozawa; Takuhisa Okada; Katsuya Osone; Takaaki Sano; Kenichiro Araki; Hiroomi Ogawa; Akihiko Sano; Makoto Sakai; Makoto Sohda; Ken Shirabe; Hiroshi Saeki, 11 May 2023, Surgical case reports, 9, 1, 76, 76, Scientific journal

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• Relationships of 18F-FDG PET with tumor microenvironment immunotypes, especially PD-L1 and CD15 expression, and prognosis in oral squamous cell carcinoma, Mai Seki; Takaaki Sano; Masaru Ogawa; Satoshi Yokoo; Tetsunari Oyama, 28 Apr. 2023, Egyptian Journal of Radiology and Nuclear Medicine, 54, 1, Scientific journal

  DOI
• 乳癌における治療関連マーカーの腫瘍内不均一性と治療効果の検討, 片山 彩香; 佐野 孝昭; 黒住 献; 藤井 孝明; 小山 徹也, Mar. 2023, 112, 1, 239, 240
• A case of solitary digital glomus tumor associated with neurofibromatosis type 1, Koichiro Yanai; Tsuyoshi Tajika; Takuro Kuboi; Yuhei Hatori; Takahiro Umeyama; Shinsuke Arisawa; Ayaka Katayama; Takaaki Sano; Hirotaka Chikuda, Jan. 2023, SAGE Open Medical Case Reports, 11, Scientific journal

  DOI
• Case of pneumatosis cystoides intestinalis with intra‐abdominal free air developed during treatment with voglibose, Etsuko Hisanaga; Takaaki Sano; Yuji Kumakura; Yozo Yokoyama; Isao Nakajima; Hitoshi Takagi, Sep. 2022, JGH Open, Scientific journal

  DOI
• Correspondence re: Sano T, Hikino T, Niwa Y, Kashiwabara K, Oyama T, Fukuda T, Nakajima T. In situ hybridization with biotinylated tyramide amplification: Detection of human papillomavirus DNA in cervical neoplastic lesions. Mod pathol 1998;11:19-23 [2] (multiple letters), Tubbs, R.R.; Hauser-Kronberger, C.; Hacker, G.W.; Sano, T.; Nakajima, T., 1998, Modern Pathology, 11, 6, Scientific journal

MISC

• 小細胞肺癌の異時性臀部転移に対して外科的切除を施行し、長期生存を得た1例, 清水祐太朗、中沢世識、矢沢友弘、河谷菜津子、尾林海、大滝容一、矢島俊樹、調憲、櫻井麗子、下田雄輝、佐野孝昭, Jun. 2022, 62, 3, 271
• 悪性腫瘍との鑑別が困難であった炎症性血管筋脂肪腫(inflammatory AML)の1例, 池谷美穂、市川智章、対馬義人、佐野孝昭, Sep. 2022, 49, 2, 20
• NRAS変異を示し、未分化癌を伴う膵粘液性嚢胞腺癌の1例, 久永 悦子 , 佐野 孝昭 , 吉田 由佳 , 石井 範洋 , 調 憲 , 伊古田 勇人, Apr. 2021, 364, 37, 37
• 乳腺病変における核形態の検討と診断への応用, 片山　彩香、トス マイケル、パーキン マシュー、佐野　孝昭、クイン セシリー、ラッカ エマド 、小山　徹也, 2022
• HER2陽性乳癌における術前化学療法の病理学的完全奏効の予測因子, 片山　彩香、椎野　翔、黒住　献、下田　雄輝、増田恵、越　浩美、佐野　孝昭、ラッカエマド、小山　徹也, 2021
• Triple negative breast cancer（TNBC）における新規治療標的候補Fibrillin 2（FBN2） 発現の臨床的意義, 金澤　彩乃、半田　正、片山　彩香、横堀　武彦、山根　有人、川端　麗香、藤井　孝明、佐野　孝昭、西山　正彦、小山　徹也, Apr. 2020
• Human papillomavirus (HPV) 56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの１例, 下田雄輝、佐野孝昭、村上千明、松山敏之、小山徹也, Apr. 2020
• 術前にS-1投与を行った口腔癌における生検・手術検体での簇出の変化について, 早田　麻衣, 佐野孝昭, 越　浩美, 横尾　聡, 小山徹也, Apr. 2020
• 甲状腺に病変を形成したランゲルハンス細胞組織球症の1例, 竹渕 友弥; 佐野 孝昭; 後藤 優典; 星川 里美; 栗原 康哲; 伊古田 勇人; 平戸 純子; 小山 徹也, May 2018, 日本臨床細胞学会雑誌, 57, 3, 177, 182
• Human Papillomavirus, 佐野孝昭; 吉田朋美; 福田利夫, 2011, 129, 289, 299
• 肝細胞癌におけるForkhead box protein C2(FOXC2)発現の意義, 下田 雄輝; 生方 泰成; 半田 正; 横堀 武彦; 片山 彩香; 佐野 孝昭; 桑野 博行; 調 憲; 小山 徹也, Apr. 2018, 日本病理学会会誌, 107, 1, 370, 370
• びまん性特発性神経内分泌過形成を背景に発生した定型カルチノイドの1切除例, 河谷 菜津子; 清水 公裕; 中澤 世識; 尾林 海; 伊部 崇史; 矢島 俊樹; 茂木 晃; 調 憲; 片山 彩香; 佐野 孝昭; 小山 徹也, Apr. 2019, 肺癌, 59, 2, 185, 186
• 核内にグリコーゲンの封入体様構造を認めた卵巣明細胞癌の1例, 吉田 玲佳; 星川 里美; 佐藤 香織; 栗原 康哲; 福田 利夫; 新井 秀雄; 佐野 孝昭; 平戸 純子; 小山 徹也, Apr. 2018, 日本臨床細胞学会雑誌, 57, Suppl.1, 372, 372
• 当院におけるEUS-FNAの細胞診結果の検討, 星川 里美; 佐野 孝昭; 平戸 純子; 小山 徹也, Apr. 2018, 日本臨床細胞学会雑誌, 57, Suppl.1, 340, 340
• 一部に粘液産生を伴い神経内分泌マーカー陽性の浸潤性乳管癌の一例, 阿部 奈津美; 佐藤 香織; 植野 舞; 堀越 可奈; 福田 利夫; 齊尾 征直; 佐野 孝昭; 小山 徹也; 竹尾 健, Apr. 2018, 日本臨床細胞学会雑誌, 57, Suppl.1, 296, 296
• 発症後22年以上の長期生存を認めた肺類上皮血管内皮腫の1例, 越 浩美; 佐野 孝昭; 早田 麻衣; 小山 徹也, Apr. 2018, 日本病理学会会誌, 107, 1, 475, 475
• 口腔扁平上皮癌における頸部リンパ節転移および予後予測因子としての生検検体における簇出の評価, 関 麻衣; 佐野 孝昭; 小山 徹也; 横尾 聡, Aug. 2017, The Kitakanto Medical Journal, 67, 3, 266, 266
• 穿刺吸引細胞診で悪性が疑われた毛母腫の1例, 吉田 玲佳; 竹渕 友弥; 星川 里美; 佐藤 香織; 栗原 康哲; 福田 利夫; 佐野 孝昭; 平戸 純子; 小山 哲也, Oct. 2017, 日本臨床細胞学会雑誌, 56, Suppl.2, 862, 862
• 乳癌における術前腋窩リンパ節穿刺吸引細胞診(LN-FNA)の有用性の検討, 星川 里美; 佐野 孝昭; 荻野 美里; 小山 徹也, Jul. 2017, 日本乳癌学会総会プログラム抄録集, 25回, 377, 377
• Triple negative乳癌におけるCarboxypeptidase A4(CPA4)発現の臨床的意義, 半田 正; 片山 彩香; 横堀 武彦; ゴンボドルジ・ナフチャ; 山根 有人; 川端 麗香; 藤井 孝明; 佐野 孝昭; 西山 正彦; 小山 徹也, Apr. 2018, 日本病理学会会誌, 107, 1, 429, 429
• 肝細胞癌におけるForkhead box protein C2(FOXC2)発現の意義, 下田 雄輝; 生方 泰成; 半田 正; 横堀 武彦; 片山 彩香; 佐野 孝昭; 桑野 博行; 調 憲; 小山 徹也, Apr. 2018, 日本病理学会会誌, 107, 1, 370, 370
• 膵内副脾に発生した類表皮嚢胞の2例, 片山 彩香; 東郷 真理亜; 小松 恵; 下田 雄輝; 伊古田 勇人; 佐野 孝昭; 小山 徹也, Apr. 2018, 日本病理学会会誌, 107, 1, 366, 366
• 乳癌の体腔液セルブロック検体における免疫染色, 星川 里美; 佐野 孝昭; 平戸 純子; 小山 徹也, May 2018, 日本乳癌学会総会プログラム抄録集, 26回, 658, 658
• 肺化膿症と鑑別を要した巨大肺癌肉腫の1切除例, 河谷 菜津子; 渥實 潤; 中澤 世識; 尾林 海; 高坂 貴行; 矢島 俊樹; 清水 公裕; 茂木 晃; 桑野 博行; 佐野 孝昭; 小山 徹也, Apr. 2018, 肺癌, 58, 2, 172, 172
• 十二指腸に多発ガストリノーマを認めた多発性内分泌腫瘍症1型(MEN1)の一例, 金澤 彩乃; 下田 雄輝; 片山 彩香; 早田 麻衣; 越 浩美; 久保 憲生; 小澤 厚志; 佐野 孝昭; 山田 正信; 小山 徹也, Apr. 2019, 108, 1, 448, 448
• 早期胃癌の腫瘍免疫に関する臨床病理学的検討, 生方 泰成; 下田 雄輝; 半田 正; 早田 麻衣; 越 浩美; 片山 彩香; 横堀 武彦; 佐野 孝昭; 調 憲; 小山 徹也, Apr. 2019, 108, 1, 371, 371
• 口腔扁平上皮癌におけるPD-L1発現と18F-FDG集積の関連について, 東郷 真理亜; 横堀 武彦; 半田 正; 佐野 孝昭; 片山 彩香; 下田 雄輝; 清水 公裕; 樋口 徹也; 横尾 聡; 小山 徹也, Apr. 2019, 108, 1, 324, 324
• 病理学の教育はこう変わる! バーチャルスライドとMoodleを利用した病理学総論アクティブラーニングの試み, 小山 徹也; 佐野 孝昭; 越 浩美; 早田 麻衣; 片山 彩香; 下田 雄輝, Apr. 2019, 108, 1, 206, 206
• 顎下腺乳腺相似分泌癌の一例, 森田 淳; 星川 里美; 後藤 優典; 吉田 玲佳; 栗原 康哲; 越 浩美; 佐野 孝昭; 小山 徹也; 伊古田 勇人, Oct. 2019, 58, Suppl.2, 674, 674
• 気管支ブラシ・気管支洗浄液検体に出現した明細胞肉腫の一例, 竹股 涼; 後藤 優典; 森田 淳; 竹渕 友弥; 星川 里美; 小野里 香織; 栗原 康哲; 佐野 孝昭; 伊古田 勇人, Oct. 2019, 58, Suppl.2, 668, 668
• パピローマウイルス感染と子宮頸部癌の発生, 中島 孝; 佐野 孝昭, Dec. 1999, 日本医学会総会会誌, 25回, I, 279, 279
• 十二指腸異所性膵組織由来と考えられ、intraductal papillary mucinous neoplasmを伴う腺癌の1例, 久永 悦子; 佐野 孝昭; 久保 憲生; 石井 範洋; 調 憲; 横山 洋三; 奥田 憲太郎; 宮前 直美; 高木 均; 平戸 純子; 伊古田 勇人, May 2020, 359回, 35, 35
• 術前にS-1投与を行った口腔癌における生検・手術検体での簇出の変化について, 早田 麻衣; 佐野 孝昭; 越 浩美; 横尾 聡; 小山 徹也, Mar. 2020, 109, 1, 396, 397
• Human papillomavirus(HPV)56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの1例, 下田 雄輝; 佐野 孝昭; 村上 千明; 松山 敏之; 小山 徹也, Mar. 2020, 109, 1, 400, 400
• Triple negative breast cancer(TNBC)における新規治療標的候補Fibrillin 2(FBN2)発現の臨床的意義, 金澤 彩乃; 半田 正; 片山 彩香; 横堀 武彦; 山根 有人; 川端 麗香; 藤井 孝明; 佐野 孝昭; 西山 正彦; 小山 徹也, Mar. 2020, 109, 1, 494, 494
• Granulocyte colony-stimulating factor(G-CSF)産生乳癌の1例, 片山 彩香; 平方 智子; 孫 莉華; 尾林 紗弥香; 黒住 献; 藤井 孝明; 佐野 孝昭; 飯野 祐一; 小山 徹也, Jul. 2019, 27, 47, 52
• Synchronous double cancer involving the uterine cervix and kidney., Katsuya Maebayashi; Norio Mitsuhashi; Mitsuhiro Takahashi; Michitaka Yamakawa; Hideyuki Sakurai; Takaaki Sano; Hideo Niibe, 1997, Kitakanto Med. J. 47(2), 47, 2, 95, 98

  DOI
• Thymoma-associated multiorgan autoimmunityが先行し、免疫療法が著効した重症筋無力症の38歳男性例, 清水 一輝; 増田 美沙季; 菅原 隆; 笠原 浩生; 牧岡 幸樹; 佐野 孝昭; 大瀧 容一; 池田 佳生, Jan. 2022, 62, 1, 88, 88
• NRAS変異を示し、未分化癌を伴う膵粘液性嚢胞腺癌の1例, 久永 悦子; 佐野 孝昭; 吉田 由佳; 石井 範洋; 調 憲; 伊古田 勇人, Apr. 2021, 364回, 37, 37
• HER2陽性乳癌における術前化学療法の病理学的完全奏功の予測因子(Predictors of pathological complete response to neoadjuvant treatment in HER2-positive breast cancer), 片山 彩香; 椎野 翔; 黒住 献; 下田 雄輝; 増田 恵; 越 博美; 佐野 孝昭; ラッカ・エマド; 小山 徹也, Mar. 2021, 日本病理学会会誌, 110, 1, 229, 229
• Triple negative breast cancer(TNBC)における新規治療標的候補Fibrillin 2(FBN2)発現の臨床的意義, 金澤 彩乃; 半田 正; 片山 彩香; 横堀 武彦; 山根 有人; 川端 麗香; 藤井 孝明; 佐野 孝昭; 西山 正彦; 小山 徹也, Mar. 2020, 109, 1, 494, 494
• 3. Predictive and prognostic role of activated mammalian target of rapamycin (mTOR) in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy, Faried L.S.; Kanuma T.; Nakazato T.; Tamura T.; Minegishi T.; Faried A.; Kuwano H.; Sano T., 01 Nov. 2007, The KITAKANTO medical journal, 57, 4, 341, 342
• 乳腺病変における核形態の検討と診断への応用, 片山 彩香; トス・マイケル; パーキン・マシュー; 佐野 孝昭; クイン・セシリー; ラッカ・エマド; 小山 徹也, Mar. 2022, 111, 1, 253, 254

Presentations

• 顎下腺乳腺相似分泌癌の1例, 第58回日本臨床細胞学会秋期大会（岡山市）, 2019
• 気管支ブラシ・気管支洗浄液検体に出現した明細胞肉腫の一例, 第58回日本臨床細胞学会秋期大会（岡山市）, 2019
• HER2陽性乳癌における術前化学療法の病理学的完全奏効の予測因子, 第110回日本病理学会総会 （東京）, 22 Apr. 2021
• Triple negative breast cancer（TNBC）における新規治療標的候補 Fibrillin 2（FBN2） 発現の臨床的意義, 第109回日本病理学会総会 (福岡), 2020
• Human papillomavirus (HPV) 56型が検出されたHPV-related multiphenotypic sinonasal carcinomaの１例, 第109回日本病理学会総会 (福岡), 2020
• 術前にS-1投与を行った口腔癌における生検・手術検体での簇出の変化について, 第109回日本病理学会総会 (福岡), 2020
• 十二指腸に多発ガストリノーマを認めた多発性内分泌腫瘍症1 型（MEN1）の一例, 第108回日本病理学会総会 (東京), 2019
• 早期胃癌の腫瘍免疫に関する臨床病理学的検討, 第108回日本病理学会総会 (東京), 2019
• 口腔扁平上皮癌におけるPD-L1 発現と18F-FDG 集積の関連について, 第108回日本病理学会総会 (東京), 2019
• バーチャルスライドとMoodle を利用した病理学総論アクティブラーニングの試み, 第108回日本病理学会総会 (東京), 2019
• 発症後22 年以上の長期生存を認めた肺類上皮血管内皮腫の１例, 第107回日本病理学会総会(札幌), 2018
• Triple negative乳癌におけるCarboxypeptidase A4（ CPA4）発現の臨床的意義, 第107回日本病理学会総会(札幌), 2018
• 肝細胞癌におけるForkhead box protein C2（FOXC2）発現の意義, 第107回日本病理学会総会(札幌), 2018
• 膵内副脾に発生した類表皮嚢胞の2例, 第107回日本病理学会総会(札幌), 2018
• 当院におけるEUS-FNAの細胞診結果の検討, 第59回日本臨床細胞学会総会（札幌）, 2018
• 核内にグリコーゲンの封入体様構造を認めた卵巣明細胞癌の1例, 第59回日本臨床細胞学会総会（札幌）, 2018
• 一部に粘液産生を伴い神経内分泌マーカー陽性の浸潤性乳管癌の一例, 第59回日本臨床細胞学会総会（札幌）, 2018

Research Projects

• HISTOPATHOLOGICAL RESEARCH OF CARCINOGENESIS OF DUCTAL CARCINOMA IN SITU, OYAMA Tetsunari; SANO Takaaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), GUNMA UNIVERSITY, 2002, 2003, It becomes more important to clarify the molecular pathological mechanism of early carcinogenesis and identify the morphological change of breast cancer according to the increase of occurrence of breast cancer. We have already proposed "atypical cystic lobules (ACL)", which is also called as columnar cell hyperplasia with atypia (CCHA). It is one type of early change of low grade ductal carcinoma in situ (DCIS). In this study, we carried out immunohistochemical analysis of breast carcinogens using several antibodies for related proteins, including hormone receptor (Estrogen receptor), hormone related protein (Estrogen-responsive RING finger protein) and 14-3-3 sigma (σ) protein. We have studied the expression of these proteins in usual ductal hyperplasia (UDH), ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). Immunostaining for estrogen receptor alpha (ERα), p53 and (Efp) was also carried out. Immunohistochemically, expression of 14-3-3σ was seen in 92% UDH lesions and gradually decreased from 65% in DCIS to 23% in IDC. The expression of ERα decreased gradually from UDH to DCIS to IDC, while p53 showed an inverse staining pattern to that of ERα. The expression of Efp showed no significant difference among the three breast lesions. Hence, the present immunohistochemical study confirmed 14-3-3σ as a tumor suppressor in breast carcinogenesis. A similar immunohistochemical analysis was then carried out on columnar cell hyperplasia with atypia (CCHA), in which the expression pattern of tumor suppressor 14-3-3σ, ERα and p53 suggested that the possibility may exist that CCHA is a pre-cancerous lesions., 14570134

  対象リソースIRI
• Study of 14-3-3 sigma protein in normal and neoplastic tissues., NAKAJIMA Takashi; MAEDA Masahiro; SANO Takaaki; OYAMA Tetsunari, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Gunma University, 2002, 2003, In normal human tissues, 14-3-3 σ protein was exclusively present in various epithelial cells, of which squamous epithelia at various sites showed the strongest immunoreactivity and basal cells of respiratory tract or myoepithelial cells of various organs followed. In non-small cell carcinoma of the lung, squamous cell carcinoma expressed stronger immunoreactivity for 14-3-3 σ protein than adenocarcinoma. In human colon cancers, immunoreactivity for 14-3-3 σ protein varied from area to area or case to case. However, there was a tendency to be positive for 14-3-3 σ expression at tumor invasion front. Molecular biological study revealed that DNA methylation of the gene did not influence the expression of the 14-3-3 σ gene in colon cancers. In breast carcinogenesis, down-regulation of 14-3-3 σ protein was well correlated with its progression. In ductal carcinoma lesions, even in non-invasive, marked down-regulation of 14-3-3 σ expression was observed. Breast borderline lesion, columnar cell hyperplasia with atypia showed different 14-3-3 σ expression pattern from that of ductal cancer lesion, suggesting it to be precancerous lesion of the breast., 14370066

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• EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER-RELATED PROTEIN IN THE PRECURSOR LESION AND ERALY LESION OF BREAST CANCER, OYAMA Tetsunari; SANO Takaaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), GUNMA UNIVERSITY SCHOOL OF MEDICINE, 1999, 2000, A.Atypical cystic lobules of the breast, an early stage of low grade ductal carcinoma in situ. The authors describe the characteristics of atypical cystic lobules (ACLs), which represent a step in the formation of low-grade ductal carcinoma in-situ. The authors defined ACLs as a proliferation of luminal cells showing low-grade cytological atypia without architectural atypia. ACLs were compared with conventional hyperplasia, low-grade ductal carcinoma in-situ and lobular neoplasia. 1) In about forty percent of the cases, atypical cystic lobules merged with fully established micropapillary/cribriform ductal carcinoma in-situ. 2) Immunohistochemical staining for hormone receptors, keratin nineteen, and cyclin D1 revealed that atypical cystic lobules demonstrate a consistent immunophenotype, which differs from the pattern shown by normal lobules and benign lesions and matches the one of low-grade ductal carcinoma in-situ. 3) ACLs are sometimes calcified. Osteopontin-positive histiocytes were infiltrated in all the Kossa-positive (type II microcalcification) cribriform and comedo type carcinomas and ACLs. The similarities in the cytological and immunohistochemical features, the close proximity of the two type of proliferation and the similarities with respect to the types of calcification suggest that atypical cystic lobules represent an early stage in the formation of certain types of low-grade ductal carcinoma in-situ. B.Microcalcification of carcinoma in situ and atypical cystic lobules of the breast with infiltration of macrophages with osteopontin. Abstract We studied the pattern of calcification and the expression of osteopontin (OP) protein and mRNA by the noninvasive components i of twenty breast cancers and sixteen atypical cystic lobules (ACLs). Ten breast cancers (Cr type) showed low-grade cribriform carcinoma in-situ containing secretory material ; the remaining ten cancers (Co type) displayed high-grade carcinoma in-situ with central necrosis. Hematoxylin-eosin and Kossa staining revealed calcium hydroxyapatite calcifications in 80% of Cr type carcinomas, 50% of Co type carcinomas and 56% of ACLs. Immunohistochemical staining demonstrated OP protein in intraluminal secretory material, necrotic debris, or stroma and in histiocytes in all the Kossa-positive carcinomas and ACLs. In situ hybridization revealed OP mRNA mainly in the histiocytes and especially in those near the calcifications. The close relation between hydroxyapatite crystals and OP producing histiocytes suggests that these cells change the microenvironment in a way that facilitates the crystallization of calcium. The similarity in the patterns of osteopontin expression by ACLs and Cr type ductal carcinomas in-situ suggests that the same mechanism gives rise to the calcifications seen in both lesions. C.Expression of Steroid receptor co-activator (SRC)-1 and SRC-3 (=amplified in breast cancer, AIB1) in several breast lesions including precursor lesions. We have tried to detect expression of SRC-1 and SRC-3 in various lesions in the breast, especially in in situ carcinoma and atypical cystic lobules (ACLs) and conventional hyperplasia. SRC-1 was demonstrated almost all nuclei, benign and malignant, in the breast in contrast that estrogen receptor was observed in partial segregated nuclei in proliferative conditions. SRC-1 was partially demonstrated in some nuclei of the high-grade invasive carcinoma., 11670166

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• 1999, 2000, 11470049

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