Researcher Profile and Settings

Researcher

• Name

  TAGO Kenji

Profile and Settings

• Name

  Tago, Kenji

Alternate Names

• Kenji Tago

Affiliation

• Gunma University, Graduate School of Health Science Laboratory Science (Basic laboratory science)

Education

• Apr. 1993, Mar. 1998, Tokyo Institute of Technology
• Apr. 1989, Mar. 1993, Saitama University

Association Memberships

• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• THE JAPANESE BIOCHEMICAL SOCIETY

Research Experience

• Apr. 2023, 9999, Gunma University, Graduate School of Health Science Laboratory Science (Basic laboratory science), Prof lv
• Apr. 2012, Mar. 2023, Jichi Medical University, School of Medicine, Department of Biochemistry, Assistant Professor, Associate prof lecturer lv
• Jun. 2006, Mar. 2012, NAIST, Department of Bioscience, Assistant Professor, Assistant prof lv
• Apr. 2002, May 2006, St. Jude Children's Research Hospital, Department of Tumor Cell Biology, Research Associate, Researcher postdoc lv
• Apr. 1998, Mar. 2002, Jichi Medical University, School of Medicine, Research Assistant, Research assistance

Research Activities

Research Areas

• Life sciences, Functional biochemistry

Published Papers

• The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB., Taisuke Murata; Sho Ishiwa; Xin Lin; Yosuke Nakazawa; Kenji Tago; Megumi Funakoshi-Tago, 27 Sep. 2023, Neurochemistry international, 171, 105613, 105613, Scientific journal

  DOI
• Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation., Shingo Hokimoto; Megumi Funakoshi-Tago; Kenji Tago, Feb. 2023, The FEBS journal, 290, 4, 988, 1007, Scientific journal

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• The indispensable role of the RNA helicase DDX5 in tumorigenesis induced by the myeloproliferative neoplasm-associated JAK2V617F mutant., Kengo Takeda; Kenji Tago; Megumi Funakoshi-Tago, Feb. 2023, Cellular signalling, 102, 110537, 110537, Scientific journal

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• GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons., Yusuke Nojima; Manami Toriyama; Kenji Tago; Norikazu Mizuno; Kazuhiro Morishita; Hiroshi Itoh, 30 Nov. 2022, Genes to cells : devoted to molecular & cellular mechanisms, Scientific journal

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• Overexpression of satellite RNAs in heterochromatin induces chromosomal instability and reflects drug sensitivity in mouse cancer cells., Sawako Tamaki; Koichi Suzuki; Iku Abe; Yuhei Endo; Nao Kakizawa; Fumiaki Watanabe; Masaaki Saito; Shingo Tsujinaka; Yasuyuki Miyakura; Satoshi Ohta; Kenji Tago; Ken Yanagisawa; Fumio Konishi; Toshiki Rikiyama, 29 Jun. 2022, Scientific reports, 12, 1, 10999, 10999, Scientific journal

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• CRISPR/CasRx-Mediated RNA Knockdown Reveals That ACE2 Is Involved in the Regulation of Oligodendroglial Cell Morphological Differentiation., Yukino Kato; Kenji Tago; Shoya Fukatsu; Miyu Okabe; Remina Shirai; Hiroaki Oizumi; Katsuya Ohbuchi; Masahiro Yamamoto; Kazushige Mizoguchi; Yuki Miyamoto; Junji Yamauchi, 06 Jun. 2022, Non-coding RNA, 8, 3, Scientific journal

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• The role of MerTK in promoting cell migration is enhanced by the oncogenic Ras/IL-33 signaling axis., Satoshi Ohta; Kenji Tago; Takahiro Kuchimaru; Megumi Funakoshi-Tago; Hisanaga Horie; Chihiro Aoki-Ohmura; Jitsuhiro Matsugi; Ken Yanagisawa, Apr. 2022, The FEBS journal, 289, 7, 1950, 1967, Scientific journal

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• A bis-pyridinium fullerene derivative induces apoptosis through the generation of ROS in BCR-ABL-positive leukemia cells., Kazuya Sumi; Kenji Tago; Yosuke Nakazawa; Kyoko Takahashi; Tomoyuki Ohe; Tadahiko Mashino; Megumi Funakoshi-Tago, 05 Feb. 2022, European journal of pharmacology, 916, 174714, 174714, Scientific journal

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• Novel Mechanism by a Bis-Pyridinium Fullerene Derivative to Induce Apoptosis by Enhancing the MEK-ERK Pathway in a Reactive Oxygen Species-Independent Manner in BCR-ABL-Positive Chronic Myeloid Leukemia-Derived K562 Cells., Kazuya Sumi; Kenji Tago; Yosuke Nakazawa; Kyoko Takahashi; Tomoyuki Ohe; Tadahiko Mashino; Megumi Funakoshi-Tago, 11 Jan. 2022, International journal of molecular sciences, 23, 2, Scientific journal

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• Hypomyelinating Leukodystrophy 7 (HLD7)-Associated Mutation of POLR3A Is Related to Defective Oligodendroglial Cell Differentiation, Which Is Ameliorated by Ibuprofen., Sui Sawaguchi; Kenji Tago; Hiroaki Oizumi; Katsuya Ohbuchi; Masahiro Yamamoto; Kazushige Mizoguchi; Yuki Miyamoto; Junji Yamauchi, 22 Dec. 2021, Neurology international, 14, 1, 11, 33, Scientific journal

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• The indole-hydantoin derivative exhibits anti-inflammatory activity by preventing the transactivation of NF-κB through the inhibition of NF-κB p65 phosphorylation at Ser276., Xin Lin; Kenji Tago; Nozomi Okazaki; Takanori So; Kyoko Takahashi; Tadahiko Mashino; Hiroomi Tamura; Megumi Funakoshi-Tago, Nov. 2021, International immunopharmacology, 100, 108092, 108092, Scientific journal

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• K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors., Kenji Tago; Satoshi Ohta; Chihiro Aoki-Ohmura; Megumi Funakoshi-Tago; Miho Sashikawa; Takeshi Matsui; Yuki Miyamoto; Taeko Wada; Tomoyuki Oshio; Mayumi Komine; Jitsuhiro Matsugi; Yusuke Furukawa; Mamitaro Ohtsuki; Junji Yamauchi; Ken Yanagisawa, 19 Oct. 2021, Scientific reports, 11, 1, 20658, 20658, Scientific journal

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• Calciprotein Particles Induce IL-1β/α-Mediated Inflammation through NLRP3 Inflammasome-Dependent and -Independent Mechanisms., Fumiya Anzai; Tadayoshi Karasawa; Takanori Komada; Naoya Yamada; Yutaka Miura; Ariunaa Sampilvanjil; Chintogtokh Baatarjav; Kenta Fujimura; Takayoshi Matsumura; Kenji Tago; Hiroshi Kurosu; Yasuchika Takeishi; Makoto Kuro-O; Masafumi Takahashi, 29 Jul. 2021, ImmunoHorizons, 5, 7, 602, 614, Scientific journal

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• Hypomyelinating Leukodystrophy 15 (HLD15)-Associated Mutation of EPRS1 Leads to Its Polymeric Aggregation in Rab7-Positive Vesicle Structures, Inhibiting Oligodendroglial Cell Morphological Differentiation., Sui Sawaguchi; Mizuki Goto; Yukino Kato; Marina Tanaka; Kenji Tago; Hiroaki Oizumi; Katsuya Ohbuchi; Kazushige Mizoguchi; Yuki Miyamoto; Junji Yamauchi, 29 Mar. 2021, Polymers, 13, 7, Scientific journal

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• The Infantile Leukoencephalopathy-Associated Mutation of C11ORF73/HIKESHI Proteins Generates de novo Interactive Activity with Filamin A, Inhibiting Oligodendroglial Cell Morphological Differentiation., Kohei Hattori; Kenji Tago; Shiori Memezawa; Arisa Ochiai; Sui Sawaguchi; Yukino Kato; Takanari Sato; Kazuma Tomizuka; Hiroaki Ooizumi; Katsuya Ohbuchi; Kazushige Mizoguchi; Yuki Miyamoto; Junji Yamauchi, 01 Feb. 2021, Medicines (Basel, Switzerland), 8, 2, Scientific journal

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• EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53., Yuki Uchihara; Kenji Tago; Hiroomi Tamura; Megumi Funakoshi-Tago, Jan. 2021, Molecular oncology, 15, 1, 167, 194, Scientific journal

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• Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells., Megumi Funakoshi-Tago; Kenji Tago; Chin Li; Shingo Hokimoto; Hiroomi Tamura, 11 Nov. 2020, Scientific reports, 10, 1, 19588, 19588, Scientific journal

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• Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2., Megumi Funakoshi-Tago; Yusuke Nonaka; Kenji Tago; Mika Takeda; Yuma Ishihara; Ami Sakai; Mari Matsutaka; Kenji Kobata; Hiroomi Tamura, 13 Feb. 2020, Scientific reports, 10, 1, 2584, 2584

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• N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties., Yuki Uchihara; Tomoyuki Ohe; Tadahiko Mashino; Takayuki Kidokoro; Kenji Tago; Hiroomi Tamura; Megumi Funakoshi-Tago, Dec. 2019, Pharmacological reports : PR, 71, 6, 1067, 1078

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• Methotrexate significantly induces apoptosis by inhibiting STAT3 activation in NPM-ALK-positive ALCL cells., Yuki Uchihara; Reiko Komori; Kenji Tago; Hiroomi Tamura; Megumi Funakoshi-Tago, Dec. 2019, Biochemical pharmacology, 170, 113666, 113666

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• Tyrosine-phosphorylated SOCS3 negatively regulates cellular transformation mediated by the myeloproliferative neoplasm-associated JAK2 V617F mutant., Megumi Funakoshi-Tago; Rina Tsuruya; Fumihito Ueda; Aki Ishihara; Tadashi Kasahara; Hiroomi Tamura; Kenji Tago, Nov. 2019, Cytokine, 123, 154753, 154753

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• Oncogenic Ras mutant causes the hyperactivation of NF-κB via acceleration of its transcriptional activation., Kenji Tago; Megumi Funakoshi-Tago; Satoshi Ohta; Hirotoshi Kawata; Hiroshi Saitoh; Hisanaga Horie; Chihiro Aoki-Ohmura; Junji Yamauchi; Akira Tanaka; Jitsuhiro Matsugi; Ken Yanagisawa, Nov. 2019, Molecular oncology, 13, 11, 2493, 2510, Scientific journal

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• [The mechanisms of taxodione-induced apoptosis in BCR-ABL-positive leukemia cells]., Yuki Uchihara; Kenji Tago; Megumi Funakoshi-Tago, 2019, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153, 4, 147, 154

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• Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation., Yuri Urai; Minami Yamawaki; Natsumi Watanabe; Yoich Seki; Takako Morimoto; Kenji Tago; Keiichi Homma; Hiroyuki Sakagami; Yuki Miyamoto; Junji Yamauchi, 10 Sep. 2018, Biochemical and biophysical research communications, 503, 3, 2047, 2053, Scientific journal

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• Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells., Megumi Funakohi-Tago; Tomoki Sakata; Satoru Fujiwara; Ayaka Sakakura; Takeshi Sugai; Kenji Tago; Hiroomi Tamura, 05 Sep. 2018, European journal of pharmacology, 834, 246, 256

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• A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis., Tomomi Niino; Kenji Tago; Daisuke Yasuda; Kyoko Takahashi; Tadahiko Mashino; Hiroomi Tamura; Megumi Funakoshi-Tago, Sep. 2018, Biochemical pharmacology, 155, 182, 197

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• Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation., Yuki Uchihara; Kenji Tago; Hidetoshi Taguchi; Yuji Narukawa; Fumiyuki Kiuchi; Hiroomi Tamura; Megumi Funakoshi-Tago, Aug. 2018, Biochemical pharmacology, 154, 357, 372

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• A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK., Yuki Uchihara; Takayuki Kidokoro; Kenji Tago; Tadahiko Mashino; Hiroomi Tamura; Megumi Funakoshi-Tago, 15 Apr. 2018, European journal of pharmacology, 825, 1, 9

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• BIG1/Arfgef1 and Arf1 regulate the initiation of myelination by Schwann cells in mice., Yuki Miyamoto; Tomohiro Torii; Kenji Tago; Akito Tanoue; Shou Takashima; Junji Yamauchi, Apr. 2018, Science advances, 4, 4, eaar4471, Scientific journal

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• ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages., Akira Kawashima; Tadayoshi Karasawa; Kenji Tago; Hiroaki Kimura; Ryo Kamata; Fumitake Usui-Kawanishi; Sachiko Watanabe; Satoshi Ohta; Megumi Funakoshi-Tago; Ken Yanagisawa; Tadashi Kasahara; Koichi Suzuki; Masafumi Takahashi, 15 Nov. 2017, Journal of immunology (Baltimore, Md. : 1950), 199, 10, 3614, 3622, Scientific journal

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• ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant., Kenji Tago; Satoshi Ohta; Masaki Kashiwada; Megumi Funakoshi-Tago; Jitsuhiro Matsugi; Shin-Ichi Tominaga; Ken Yanagisawa, Oct. 2017, Heliyon, 3, 10, e00436

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• Heterotrimeric G protein Gαs subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction., Kazue Sugiyama; Kenji Tago; Sayumi Matsushita; Masashi Nishikawa; Katsuya Sato; Yoshinori Muto; Takahiro Nagase; Hiroshi Ueda, Apr. 2017, Cellular signalling, 32, 115, 123, Scientific journal

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• Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis., Fumihito Ueda; Kenji Tago; Hiroomi Tamura; Megumi Funakoshi-Tago, 03 Feb. 2017, The Journal of biological chemistry, 292, 5, 1826, 1846, Scientific journal

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• Phosphorylated CIS suppresses the Epo or JAK2 V617F mutant-triggered cell proliferation through binding to EpoR., Megumi Funakoshi-Tago; Takuro Moriwaki; Fumihito Ueda; Hiroomi Tamura; Tadashi Kasahara; Kenji Tago, Feb. 2017, Cellular signalling, 31, 41, 57, Scientific journal

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• STAT3 and ERK pathways are involved in cell growth stimulation of the ST2/IL1RL1 promoter., Kenji Tago; Satoshi Ohta; Megumi Funakoshi-Tago; Chihiro Aoki-Ohmura; Jitsuhiro Matsugi; Shin-Ichi Tominaga; Ken Yanagisawa, Feb. 2017, FEBS open bio, 7, 2, 293, 302, Scientific journal

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• Coffee extract inhibits adipogenesis in 3T3-L1 preadipocyes by interrupting insulin signaling through the downregulation of IRS1., Chihiro Maki; Megumi Funakoshi-Tago; Ryohei Aoyagi; Fumihito Ueda; Masaki Kimura; Kenji Kobata; Kenji Tago; Hiroomi Tamura, 2017, PloS one, 12, 3, e0173264, Scientific journal

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• Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK., Yuki Uchihara; Fumihito Ueda; Kenji Tago; Yosuke Nakazawa; Tomoyuki Ohe; Tadahiko Mashino; Shigenobu Yokota; Tadashi Kasahara; Hiroomi Tamura; Megumi Funakoshi-Tago, 2017, PloS one, 12, 8, e0183003, Scientific journal

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• A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-kappa B activation, Megumi Funakoshi-Tago; Yurika Miyagawa; Fumihito Ueda; Tadahiko Mashino; Yasuhiro Moriwaki; Kenji Tago; Tadashi Kasahara; Hiroomi Tamura, Nov. 2016, INTERNATIONAL IMMUNOPHARMACOLOGY, 40, 254, 264, Scientific journal

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• Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway, Megumi Funakoshi-Tago; Kentaro Ohsawa; Toshiyuki Ishikawa; Fumika Nakamura; Fumihito Ueda; Yuji Narukawa; Fumiyuki Kiuchi; Hiroomi Tamura; Kenji Tago; Tadashi Kasahara, Nov. 2016, INTERNATIONAL IMMUNOPHARMACOLOGY, 40, 550, 560, Scientific journal

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• ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression, Kazuhisa Watanabe; Kazuhiro Nakayama; Satoshi Ohta; Kenji Tago; Supichaya Boonvisut; Elizabeth J. Millings; Stuart G. Fischer; Charles A. LeDuc; Rudolph L. Leibel; Sadahiko Iwamoto, Sep. 2016, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477, 4, 712, 716, Scientific journal

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• Intracellular NF-HEV/IL-33 harbors essential roles in Ras-induced cellular transformation by contributing to cyclin D1 protein synthesis, Satoshi Ohta; Kenji Tago; Megumi Funakoshi-Tago; Jitsuhiro Matsugi; Ken Yanagisawa, Aug. 2016, CELLULAR SIGNALLING, 28, 8, 1025, 1036, Scientific journal

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• Soluble form of the ST2 gene product exhibits growth promoting activity in NIH-3T3 cells, Shin-ichi Tominaga; Satoshi Ohta; Kenji Tago, 01 Mar. 2016, Biochemistry and Biophysics Reports, 5, 8, 15, Scientific journal

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• A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation, Megumi Funakoshi-Tago; Takahiro Hattori; Fumihito Ueda; Kenji Tago; Tomoyuki Ohe; Tadahiko Mashino; Hiroomi Tamura, 01 Mar. 2016, Biochemistry and Biophysics Reports, 5, 259, 265, Scientific journal

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• DDX5 is a novel targeting protein of tumor suppressor ARF, Kenji Tago; Megumi Funakoshi-Tago, 2016, Seikagaku, 88, 2, 207, 210, Scientific journal

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• Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia R. Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-kappa B, Fumihito Ueda; Keito Iizuka; Kenji Tago; Yuji Narukawa; Fumiyuki Kiuchi; Tadashi Kasahara; Hiroomi Tamura; Megumi Funakoshi-Tago, Oct. 2015, INTERNATIONAL IMMUNOPHARMACOLOGY, 28, 2, 967, 976, Scientific journal

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• Agonistic Antibodies Reveal the Function of GPR56 in Human Glioma U87-MG Cells, Shigeyuki Ohta; Sayaka Sakaguchi; Yuki Kobayashi; Norikazu Mizuno; Kenji Tago; Hiroshi Itoh, Apr. 2015, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38, 4, 594, 600, Scientific journal

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• Dual function of IL-33 on proliferation of NIH-3T3 cells, Shin-ichi Tominaga; Kenji Tago; Hidetoshi Tsuda; Mayumi Komine, Mar. 2015, CYTOKINE, 72, 1, 105, 108, Scientific journal

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• Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway, Megumi Funakoshi-Tago; Kazuhi Okamoto; Rika Izumi; Kenji Tago; Ken Yanagisawa; Yuji Narukawa; Fumiyuld Kiuchi; Tadashi Kasahara; Hiroomi Tamura, Mar. 2015, INTERNATIONAL IMMUNOPHARMACOLOGY, 25, 1, 189, 198, Scientific journal

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• Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5, K. Tago; M. Funakoshi-Tago; H. Itoh; Y. Furukawa; J. Kikuchi; T. Kato; K. Suzuki; K. Yanagisawa, Jan. 2015, ONCOGENE, 34, 3, 310, 318, Scientific journal

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• Arf6 guanine nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth., Tomohiro Torii; Yuki Miyamoto; Kenji Tago; Kazunori Sango; Kazuaki Nakamura; Atsushi Sanbe; Akito Tanoue; Junji Yamauchi, 05 Dec. 2014, The Journal of biological chemistry, 289, 49, 33887, 903, Scientific journal

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• Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant, Megumi Funakoshi-Tago; Masaki Tsukada; Toshiro Watanabe; Yuka Mameda; Kenji Tago; Tomoyuki Ohe; Shigeo Nakamura; Tadahiko Mashino; Tadashi Kasahara, May 2014, INTERNATIONAL IMMUNOPHARMACOLOGY, 20, 1, 258, 263, Scientific journal

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• NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes, Yoshiyuki Inoue; Koumei Shirasuna; Hiroaki Kimura; Fumitake Usui; Akira Kawashima; Tadayoshi Karasawa; Kenji Tago; Katsuya Dezaki; Satoshi Nishimura; Junji Sagara; Tetsuo Noda; Yoichiro Iwakura; Hiroko Tsutsui; Shun'ichiro Taniguchi; Ken Yanagisawa; Toshihiko Yada; Yoshikazu Yasuda; Masafumi Takahashi, May 2014, JOURNAL OF IMMUNOLOGY, 192, 9, 4342, 4351, Scientific journal

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• Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: Involvement of Ric-8B in Gs suppression by Gq signal, Riris I Jenie; Motoki Nishimura; Mika Fujino; Michio Nakaya; Norikazu Mizuno; Kenji Tago; Hitoshi Kurose; Hiroshi Itoh, Dec. 2013, Genes to Cells, 18, 12, 1095, 1106, Scientific journal

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• Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs, Fumihito Ueda; Kazuya Sumi; Kenji Tago; Tadashi Kasahara; Megumi Funakoshi-Tago, Nov. 2013, Cellular Signalling, 25, 11, 2115, 2124, Scientific journal

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• Critical Roles of Myc-ODC Axis in the Cellular Transformation Induced by Myeloproliferative Neoplasm-Associated JAK2 V617F Mutant, Megumi Funakoshi-Tago; Kazuya Sumi; Tadashi Kasahara; Kenji Tago, 03 Jan. 2013, PLoS ONE, 8, 1, e52844, Scientific journal

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• Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway, Megumi Funakoshi-Tago; Tatsuaki Nagata; Kenji Tago; Masaki Tsukada; Kazuyuki Tanaka; Shigeo Nakamura; Tadahiko Mashino; Tadashi Kasahara, Nov. 2012, CELLULAR SIGNALLING, 24, 11, 2024, 2034, Scientific journal

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• Rab33a Mediates Anterograde Vesicular Transport for Membrane Exocytosis and Axon Outgrowth, Hitomi Nakazawa; Tadayuki Sada; Michinori Toriyama; Kenji Tago; Tadao Sugiura; Mitsunori Fukuda; Naoyuki Inagaki, Sep. 2012, JOURNAL OF NEUROSCIENCE, 32, 37, 12712, 12725, Scientific journal

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• Phosphorylation of Doublecortin by Protein Kinase A Orchestrates Microtubule and Actin Dynamics to Promote Neuronal Progenitor Cell Migration, Manami Toriyama; Norikazu Mizuno; Takashi Fukami; Tokuichi Iguchi; Michinori Toriyama; Kenji Tago; Hiroshi Itoh, Apr. 2012, JOURNAL OF BIOLOGICAL CHEMISTRY, 287, 16, 12691, 12702, Scientific journal

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• Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin, Megumi Funakoshi-Tago; Kei Nakamura; Kenji Tago; Tadahiko Mashino; Tadashi Kasahara, Sep. 2011, INTERNATIONAL IMMUNOPHARMACOLOGY, 11, 9, 1150, 1159, Scientific journal

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• Aurora kinase A critically contributes to the resistance to anti-cancer drug cisplatin in JAK2 V617F mutant-induced transformed cells, Kazuya Sumi; Kenji Tago; Tadashi Kasahara; Megumi Funakoshi-Tago, Jun. 2011, FEBS LETTERS, 585, 12, 1884, 1890, Scientific journal

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• Akt activation through the phosphorylation of erythropoietin receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation, Jun Kamishimoto; Kenji Tago; Tadashi Kasahara; Megumi Funakoshi-Tago, May 2011, CELLULAR SIGNALLING, 23, 5, 849, 856, Scientific journal

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• JAK2 is an important signal transducer in IL-33-induced NF-kappa B activation, Megumi Funakoshi-Tago; Kenji Tago; Yoshinori Sato; Shin-ichi Tominaga; Tadashi Kasahara, Feb. 2011, CELLULAR SIGNALLING, 23, 2, 363, 370, Scientific journal

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• kappa B-Ras Is a Nuclear-Cytoplasmic Small GTPase That Inhibits NF-kappa B Activation through the Suppression of Transcriptional Activation of p65/RelA, Kenji Tago; Megumi Funakoshi-Tago; Masaki Sakinawa; Norikazu Mizuno; Hiroshi Itoh, Oct. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 40, 30622, 30633, Scientific journal

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• Structural basis for the specific inhibition of heterotrimeric G(q) protein by a small molecule, Akiyuki Nishimura; Ken Kitano; Jun Takasaki; Masatoshi Taniguchi; Norikazu Mizuno; Kenji Tago; Toshio Hakoshima; Hiroshi Itoh, Aug. 2010, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107, 31, 13666, 13671, Scientific journal

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• Ric-8B Stabilizes the alpha Subunit of Stimulatory G Protein by Inhibiting Its Ubiquitination, Yusuke Nagai; Akiyuki Nishimura; Kenji Tago; Norikazu Mizuno; Hiroshi Itoh, Apr. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 15, 11114, 11120, Scientific journal

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• STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F Mutant, Megumi Funakoshi-Tago; Kenji Tago; Miyuki Abe; Yoshiko Sonoda; Tadashi Kasahara, Feb. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285, 8, 5296, 5307, Scientific journal

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• Licochalcone A Potently Inhibits Tumor Necrosis Factor alpha-Induced Nuclear Factor-kappa B Activation through the Direct Inhibition of I kappa B Kinase Complex Activation, Megumi Funakoshi-Tago; Saeko Tanabe; Kenji Tago; Hiroshi Itoh; Tadahiko Mashino; Yoshiko Sonoda; Tadashi Kasahara, Oct. 2009, MOLECULAR PHARMACOLOGY, 76, 4, 745, 753, Scientific journal

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• The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice, Miyuki Abe; Megumi Funakoshi-Tago; Kenji Tago; Jun Kamishimoto; Eriko Aizu-Yokota; Yoshiko Sonoda; Tadashi Kasahara, Jul. 2009, INTERNATIONAL IMMUNOPHARMACOLOGY, 9, 7-8, 870, 877, Scientific journal

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• G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor, Asuka Nakata; Daisuke Urano; Yoshiaki Fujii-Kuriyama; Norikazu Mizuno; Kenji Tago; Hiroshi Itoh, Jun. 2009, EMBO REPORTS, 10, 6, 622, 628, Scientific journal

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• Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappa B p65 phosphorylation at serine 276, Jun-Ichi Furusawa; Megurmi Funakoshi-Tago; Kenji Tago; Tadahiko Mashino; Hideo Inoue; Yoshiko Sonoda; Tadashi Kasahara, May 2009, CELLULAR SIGNALLING, 21, 5, 778, 785, Scientific journal

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• The Acute Lymphoblastic Leukemia-associated JAK2 L611S Mutant Induces Tumorigenesis in Nude Mice, Megumi Funakoshi-Tago; Kenji Tago; Kazuya Sumi; Miyuki Abe; Eriko Aizu-Yokota; Tomoyuki Oshio; Yoshiko Sonoda; Tadashi Kasahara, May 2009, JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 19, 12680, 12690, Scientific journal

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• Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappa B p65 in LPS signaling pathway, Jun-ichi Furusawa; Megumi Funakoshi-Tago; Tadahiko Mashino; Kenji Tago; Hideo Inoue; Yoshiko Sonoda; Tadashi Kasahara, Apr. 2009, INTERNATIONAL IMMUNOPHARMACOLOGY, 9, 4, 499, 507, Scientific journal

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• TRAF6 negatively regulates TNF alpha-induced NF-kappa B activation, Megumi Funakoshi-Tago; Noriyuki Kamada; Taeko Shimizu; Yusuke Hashiguchi; Kenji Tago; Yoshiko Sonoda; Tadashi Kasahara, Feb. 2009, CYTOKINE, 45, 2, 72, 79, Scientific journal

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• Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation, Megumi Funakoshi-Tago; Kenji Tago; Chiho Nishizawa; Kyoko Takahashi; Tadahiko Mashino; Susumu Iwata; Hideo Inoue; Yoshiko Sonoda; Tadashi Kasahara, Dec. 2008, BIOCHEMICAL PHARMACOLOGY, 76, 12, 1681, 1693, Scientific journal

  DOI
• Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway, Megumi Funakoshi-Tago; Kenji Tago; Tadashi Kasahara; Evan Parganas; James N. Ihle, Nov. 2008, CELLULAR SIGNALLING, 20, 11, 1995, 2001, Scientific journal

  DOI
• TRAF6 is a critical signal transducer in IL-33 signaling pathway, Megumi Funakoshi-Tago; Kenji Tago; Morisada Hayakawa; Shin-ichi Tominaga; Tomoyuki Ohshio; Yoshiko Sonoda; Tadashi Kasahara, Sep. 2008, CELLULAR SIGNALLING, 20, 9, 1679, 1686, Scientific journal

  DOI
• Celecoxib potently inhibits TNF alpha-induced nuclear translocation and activation of NF-kappa B, Megumi Funakoshi-Tago; Taeko Shimizu; Kenji Tago; Motohiro Nakamura; Hiroshi Itoh; Yoshiko Sonoda; Tadashi Kasahara, Sep. 2008, BIOCHEMICAL PHARMACOLOGY, 76, 5, 662, 671, Scientific journal

  DOI
• Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein beta gamma subunits and PKA, Daisuke Urano; Asuka Nakata; Norikazu Mizuno; Kenji Tago; Hiroshi Itoh, Aug. 2008, CELLULAR SIGNALLING, 20, 8, 1545, 1554, Scientific journal

  DOI
• Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha(12/13) and rho pathway, Tokuichi Iguchi; Kensei Sakata; Kotaro Yoshizaki; Kenji Tago; Norikazu Mizuno; Hiroshi Itoh, May 2008, JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 21, 14469, 14478, Scientific journal

  DOI
• The lipid raft proteins flotillins/reggies interact with G alpha q and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase, Yo Sugawara; Hiroko Nishii; Tomoko Takahashi; Junji Yamauchi; Norikazu Mizuno; Kenji Tago; Hiroshi Itoh, Jun. 2007, CELLULAR SIGNALLING, 19, 6, 1301, 1308, Scientific journal

  DOI
• Ubiquitination of, and sumoylation by, the Arf tumor suppressor, W den Besten; ML Kuo; K Tago; RT Williams; CJ Sherr, Apr. 2006, ISRAEL MEDICAL ASSOCIATION JOURNAL, 8, 4, 249, 251, Scientific journal
• Sumoylation induced by the Arf tumor suppressor: A p53-independent function, K Tago; S Chiocca; CJ Sherr, May 2005, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 21, 7689, 7694, Scientific journal

  DOI
• Functional role of c-src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex, M Funakoshi-Tago; K Tago; K Andoh; Y Sonoda; S Tominaga; T Kasahara, Feb. 2005, JOURNAL OF BIOCHEMISTRY, 137, 2, 189, 197, Scientific journal

  DOI
• p53-dependent and -independent functions of the Arf tumor suppressor, C. J. Sherr; D. Bertwistle; W. Den Besten; M. -L. Kuo; M. Sugimoto; K. Tago; R. T. Williams; F. Zindy; M. F. Roussel, 2005, MOLECULAR APPROACHES TO CONTROLLING CANCER, 70, 129, 137, International conference proceedings

  DOI
• Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV., Iwahana H; Hayakawa M; Kuroiwa K; Tago K; Yanagisawa K; Noji S; Tominaga S, Nov. 2004, Biochimica et biophysica acta, 1681, 1, 1, 14

  DOI
• Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV, H Iwahana; M Hayakawa; K Kuroiwa; K Tago; K Yanagisawa; S Noji; S Tominaga, Nov. 2004, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1681, 1, 1, 14, Scientific journal

  DOI
• Tumor necrosis factor-induced nuclear factor kappa B activation is impaired in focal adhesion kinase-deficient fibroblasts, M Funakoshi-Tago; Y Sonoda; S Tanaka; K Hashimoto; K Tago; S Tominaga; T Kasahara, Aug. 2003, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 31, 29359, 29365, Scientific journal

  DOI
• TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway, M Funakoshi-Tago; K Tago; Y Sonoda; S Tominaga; T Kasahara, Mar. 2003, EUROPEAN JOURNAL OF BIOCHEMISTRY, 270, 6, 1257, 1268, Scientific journal

  DOI
• A novel splice variant of mouse interleukin-1-receptor-associated kinase-1 (IRAK-1) activates nuclear factor-kappa B (NF-kappa B) and c-Jun N-terminal kinase (JNK), K Yanagisawa; K Tago; M Hayakawa; M Ohki; H Iwahana; S Tominaga, Feb. 2003, BIOCHEMICAL JOURNAL, 370, Pt 1, 159, 166, Scientific journal

  DOI
• TNF-induced NF-kappa B activation is impaired in focal adhesion kinase (FAK)-deficient fibroblasts, T Kasahara; M Funakoshi-Tago; Y Sonoda; K Tago; S Tominaga, 2003, PROCEEDINGS OF THE INTERNATIONAL CYTOKINE SOCIETY ANNUAL MEETING, 85, 88, International conference proceedings
• Presence of a genistein-responsive inhibitory mechanism on interleukin-1 alpha-induced NF-kappa B activation, K Tago; M Funakoshi; H Mano; K Yanagisawa; M Hayakawa; K Kuroiwa; H Iwahana; T Kasahara; S Tominaga, Dec. 2001, EUROPEAN JOURNAL OF BIOCHEMISTRY, 268, 24, 6526, 6533, Scientific journal
• Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V, K Tago; T Noda; M Hayakawa; H Iwahana; K Yanagisawa; T Yashiro; S Tominaga, Aug. 2001, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 285, 5, 1377, 1383, Scientific journal

  DOI
• Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation, K Oshikawa; K Kuroiwa; K Tago; H Iwahana; K Yanagisawa; S Ohno; SI Tominaga; Y Sugiyama, Jul. 2001, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 164, 2, 277, 281, Scientific journal

  DOI
• A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappa B activation by the enhanced and sustained degradation of I kappa B alpha, M Funakoshi; K Tago; Y Sonoda; S Tominaga; T Kasahara, Apr. 2001, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 283, 1, 248, 254, Scientific journal

  DOI
• Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-kappa B and AP-1 activation, M Funakoshi; Y Sonoda; K Tago; S Tominaga; T Kasahara, Mar. 2001, INTERNATIONAL IMMUNOPHARMACOLOGY, 1, 3, 595, 604, Scientific journal

  DOI
• The cloning and nucleotide sequence of human ST2L cDNA, HJ Li; K Tago; KC Lo; K Kuroiwa; T Arai; H Iwahana; S Tominaga; K Yanagisawa, Aug. 2000, GENOMICS, 67, 3, 284, 290, Scientific journal

  DOI
• Construction of ELISA system to quantify human ST2 protein in sera of patients, K Kuroiwa; HJ Li; K Tago; H Iwahana; K Yanagisawa; N Komatsu; K Oshikawa; Y Sugiyama; T Arai; SI Tominaga, Apr. 2000, HYBRIDOMA, 19, 2, 151, 159, Scientific journal

  DOI
• Mechanisms of immunomodulation induced by blood transfusion: Identification of humoral factors, H Uchida; H Tanaka; Y Kitoh; K Yanagisawa; H To; K Tago; K Mizuta; A Fujimura; S Tominaga; K Hashizume; E Kobayashi, Mar. 2000, TRANSPLANTATION PROCEEDINGS, 32, 2, 255, 256, Scientific journal

  DOI
• Cooperation of Six and Eya in activation of their target genes through nuclear translocation of Eya, H Ohto; S Kamada; K Tago; S Tominaga; H Ozaki; S Sato; K Kawakami, Oct. 1999, MOLECULAR AND CELLULAR BIOLOGY, 19, 10, 6815, 6824, Scientific journal
• Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM, S Tominaga; K Kuroiwa; K Tago; H Iwahana; K Yanagisawa; N Komatsu, Oct. 1999, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 264, 1, 14, 18, Scientific journal

  DOI
• Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UF7 and TM12 cells, H Iwahana; K Yanagisawa; A Ito-Kosaka; K Kuroiwa; K Tago; N Komatsu; R Katashima; M Itakura; S Tominaga, Sep. 1999, EUROPEAN JOURNAL OF BIOCHEMISTRY, 264, 2, 397, 406, Scientific journal

  DOI
• Functional involvement of mSos in interleukin-3 and thrombin stimulation of the Ras, mitogen-activated protein kinase pathway in BaF3 murine hematopoietic cells, K Tago; Y Kaziro; T Satoh, Apr. 1998, JOURNAL OF BIOCHEMISTRY, 123, 4, 659, 667, Scientific journal
• Augmentation by calmodulin of ADP-ribosylation factor-stimulated phospholipase D activity in permeabilized rabbit peritoneal neutrophils, K Takahashi; K Tago; H Okano; Y Ohya; T Katada; Y Kanaho, Feb. 1996, JOURNAL OF IMMUNOLOGY, 156, 3, 1229, 1234, Scientific journal
• SYNERGISTIC ACTIVATION OF RAT-BRAIN PHOSPHOLIPASE-D BY ADP-RIBOSYLATION FACTOR AND RHOA P21, AND ITS INHIBITION BY CLOSTRIDIUM-BOTULINUM C3 EXOENZYME, H KURIBARA; K TAGO; T YOKOZEKI; T SASAKI; Y TAKAI; N MORII; S NARUMIYA; T KATADA; Y KANAHO, Oct. 1995, JOURNAL OF BIOLOGICAL CHEMISTRY, 270, 43, 25667, 25671, Scientific journal

  DOI
• The citrus flavonoid, nobiletin inhibits neuronal inflammation by preventing the activation of NF-κB., Murata Taisuke;Ishiwa Sho;Lin Xin;Nakazawa Yosuke;Tago Kenji;Funakoshi-Tago Megumi, Sep. 2023, Neurochemistry international, 171

  DOI
• The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis., Korai Akira;Lin Xin;Tago Kenji;Funakoshi-Tago Megumi, Nov. 2023, Cellular signalling, 114

  DOI
• Suppression of Neuroinflammation by Coffee Component Pyrocatechol via Inhibition of NF-κB in Microglia., Murata Taisuke;Tago Kenji;Miyata Kota;Moriwaki Yasuhiro;Misawa Hidemi;Kobata Kenji;Nakazawa Yosuke;Tamura Hiroomi;Funakoshi-Tago Megumi, Dec. 2023, International journal of molecular sciences, 25, 1

  DOI
• Immunoblotting法の基礎と応用, 多胡 憲治, Jul. 2023, 2023, 167

MISC

• Immunoblotting法の基礎と応用, 多胡憲治, 2023, 2023
• 融合型チロシンキナーゼNPM-ALKによる発がん誘導におけるSTAT3のアセチル化の機能解析, 向來 朗; リン・シン; 多胡 めぐみ; 多胡 憲治, Nov. 2022, 95回, 2T12a, 02
• エリスロポエチンによるSTAT5非依存的な細胞増殖誘導の分子機構の解析, 武田 健吾; 多胡 憲治; 上田 史仁; 多胡 めぐみ, Nov. 2022, 95回, 2T12a, 04
• κB-Ras結合タンパク質TRB3は新規のがん抑制シグナル分子として機能する, 多胡 憲治; 杉山 直幸; 太田 聡; 大村 千尋; 松儀 実広; 柳澤 健; 冨永 薫; 伊東 広; 多胡 めぐみ, Nov. 2022, 95回, 2T12a, 05
• Ras発がんシグナルにおける新規がん抑制遺伝子産物RGS16の機能解析, 大多和 宏季; 大村 千尋; 太田 聡; 松儀 実広; 多胡 めぐみ; 富永 薫; 多胡 憲治, Nov. 2022, 95回, 2T12a, 08
• コーヒーによる神経炎症の抑制分子メカニズムの解析, 村田 大典; 森脇 康博; 多胡 憲治; 中澤 洋介; 田村 悦臣; 多胡 めぐみ, Nov. 2022, 95回, 2T13a, 08
• SARS-CoV-2受容体であるACE2は、Rasを制御することでオリゴデンドロサイトの分化を制御する, 加藤 有希乃; 白井 玲美奈; 多胡 憲治; 山内 淳司, Nov. 2022, 95回, 1P, 345
• JAK2V617F変異体によるRNAヘリカーゼDDX5の発現誘導機構とその機能の解析, 武田 健吾; 多胡 憲治; 上田 史仁; 多胡 めぐみ, Mar. 2022, 142年会, 27H, pm08S
• ビスピリジニウム型フラーレン誘導体によるBCR-ABL陽性K562細胞のアポトーシス誘導機構の解析, 鷲見 和也; 多胡 憲治; 中澤 洋介; 高橋 恭子; 大江 知之; 増野 匡彦; 多胡 めぐみ, Mar. 2022, 142年会, 28S, am01S
• 未分化大細胞リンパ腫の原因遺伝子産物NPM-ALKによるSTAT3のリン酸化を介した発がん誘導機構, 林 シン; 上田 史仁; 多胡 憲治; 多胡 めぐみ, Nov. 2021, 94回, [P, 598]
• 慢性骨髄増殖性腫瘍の原因遺伝子産物JAK2V617F変異体によるDDX5を介した発がん誘導機構の解析, 武田 健吾; 多胡 憲治; 上田 史仁; 多胡 めぐみ, Nov. 2021, 94回, [P, 602]
• JAK2V617F変異体による腫瘍形成に及ぼすDDX5の役割, 武田 健吾; 仲本 眞子; 多胡 憲治; 上田 史仁; 多胡 めぐみ, Mar. 2021, 141年会, 27V05, am03S
• NPM-ALK発現ALCLにおけるメトトレキサートによるアポトーシス誘導機構, 芳谷 郁実; 初田 航一; 内原 脩貴; 多胡 憲治; 多胡 めぐみ, Mar. 2021, 141年会, 27V05, pm20S
• K15 promoter-driven enforced expression of κB-Ras exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors, 多胡憲治; 太田聡; 大村千尋; 多胡めぐみ; 松井毅; 宮本幸; 和田妙子; 小宮根真弓; 松儀実広; 古川雄祐; 大槻マミ太郎; 山内淳司; 山内淳司; 柳澤健, 2021, 日本分子生物学会年会プログラム・要旨集(Web), 44th
• The role of STK38 (NDR1) in cell migration induced by Ras/IL-33/MerTK pathway, 太田聡; 多胡憲治; 松儀実広; 柳澤健, 2021, 日本分子生物学会年会プログラム・要旨集(Web), 44th
• 次世代のグリアバイオロジー〜新しい機能から疾患と創薬標的分子ハンティングまで〜 神経線維腫症I型の発症と低分子量Gタンパク質シグナル, 多胡 憲治; 多胡 めぐみ; 太田 聡; 大村 千尋; 小宮根 真弓; 岡田 寛文; 松儀 実広; 大槻 マミ太郎; 柳澤 健, Sep. 2020, 93回, [1S07e, 06]
• ST2Lの新規結合タンパク質IFITM3はST2Lのリソソーム分解を介してIL-33シグナルを抑制する, 多胡 憲治; 多胡 めぐみ; 太田 聡; 大村 千尋; 松儀 実広; 富永 眞一; 柳澤 健, Sep. 2019, 日本生化学会大会プログラム・講演要旨集, 92回, [1T07a, 02]
• 核小体に局在するNPM-ALKの機能解析, 内原 脩貴; 多胡 めぐみ; 多胡 憲治; 田村 悦臣, Sep. 2019, 92回, [3T18a, 01]
• ST2Lの新規結合タンパク質IFITM3はST2Lのリソソーム分解を介してIL-33シグナルを抑制する, 多胡 憲治; 多胡 めぐみ; 太田 聡; 大村 千尋; 松儀 実広; 富永 眞一; 柳澤 健, Sep. 2019, 日本生化学会大会プログラム・講演要旨集, 92回, [1T07a, 02]
• 核小体に局在するNPM-ALKの機能解析, 内原 脩貴; 多胡 めぐみ; 多胡 憲治; 田村 悦臣, Sep. 2019, 92回, [3T18a, 01]
• ラクウショウ含有タキソジオンによるBCR-ABL陽性白血病細胞のアポトーシス誘導機構, 内原 脩貴; 多胡 憲治; 多胡 めぐみ, Apr. 2019, 153, 4, 147, 154
• NPM-ALK発現細胞におけるメトトレキサートによるアポトーシス誘導機構, 内原 脩貴; 小森 麗子; 大藏 晃; 多胡 めぐみ; 多胡 憲治; 田村 悦臣, Mar. 2019, 139年会, 3, 51, 51
• MethotrexateによるBCR-ABL陽性白血病細胞のアポトーシス誘導機構の解析, 伊勢田 昂成; 迫 ゆうか; 内原 脩貴; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Mar. 2019, 139年会, 3, 128, 128
• MethotrexateによるJAK-STAT経路の阻害機構の解析, 大藏 晃; 内原 脩貴; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Mar. 2019, 139年会, 3, 128, 128
• 抗炎症作用を示すコーヒー含有成分の同定, 豊嶋 直樹; 松高 茉里; 古旗 賢二; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Mar. 2019, 139年会, 3, 216, 216
• がん化型Ras変異体はp38-MSK1/2経路を介してNF-κB活性化を増強する, 多胡 憲治; 多胡 めぐみ; 太田 聡; 河田 浩敏; 堀江 久永; 齊藤 博司; 山内 淳司; 田中 亨; 松儀 実広; 柳澤 健, Sep. 2018, 日本生化学会大会プログラム・講演要旨集, 91回, [3T12a, 215)]
• がん化型Ras変異体はp38-MSK1/2経路を介してNF-κB活性化を増強する, 多胡 憲治; 多胡 めぐみ; 太田 聡; 河田 浩敏; 堀江 久永; 齊藤 博司; 山内 淳司; 田中 亨; 松儀 実広; 柳澤 健, Sep. 2018, 日本生化学会大会プログラム・講演要旨集, 91回, [3T12a, 05(3P
• 核小体に局在するNPM-ALKの結合分子の同定, 内原 脩貴; 多胡 めぐみ; 多胡 憲治; 田村 悦臣, Sep. 2018, 日本生化学会大会プログラム・講演要旨集, 91回, [3T12a, 09(3P
• Ras変異体が誘導する発がんシグナルにおける受容体型チロシンキナーゼMer(MerTK)の機能解析, 太田 聡; 多胡 憲治; 松儀 実広; 柳澤 健, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [2P, 0448]
• NPM-ALKの細胞内局在制御機構の解析, 内原 脩貴; 多胡 めぐみ; 多胡 憲治; 田村 悦臣, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [2P, 0460]
• KRasタンパク質のC末端側における新規の点変異は特異な生化学的特性と細胞がん化能を示す, 多胡 憲治; 多胡 めぐみ; 太田 聡; 大村 千尋; 松儀 実広; 柳澤 健, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [4LT19, 02(3P
• 【TSLPとIL-33に関する新知見】 細胞のがん化におけるIL-33前駆体の新しい機能とその分子機構に関する新たな知見, 太田 聡; 多胡 憲治; 柳澤 健, Mar. 2017, 臨床免疫・アレルギー科, 67, 3, 275, 281
• がん化型Ras変異体はNF-κBの転写活性化を促進する, 多胡 憲治; 多胡 めぐみ; 太田 聡; 河田 浩敏; 堀江 久永; 山内 淳司; 田中 亨; 松儀 実広; 柳澤 健, Sep. 2016, 日本生化学会大会プログラム・講演要旨集, 89回, [2T10, 07(2P
• 慢性骨髄増殖性腫瘍に対するメトトレキサートの新しい作用機序, 内原 脩貴; 四元 佑樹; 上田 史仁; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Sep. 2016, 日本生化学会大会プログラム・講演要旨集, 89回, [2P, 241]
• がん抑制遺伝子産物ARFの新しい標的タンパク質DDX5, 多胡 憲治; 多胡 めぐみ, Apr. 2016, 生化学, 88, 2, 207, 210

  DOI
• ParvifloronEによるTNFαシグナル伝達経路の抑制機構の解明, 小室 友紀; 野村 さやか; 多胡 憲治; 成川 佑次; 木内 文之; 多胡 めぐみ; 田村 悦臣, Mar. 2016, 日本薬学会年会要旨集, 136年会, 3, 125, 125
• コーヒー豆抽出液が示す抗炎症作用の検討, 谷尾 真由美; 野中 勇佑; 武田 峰佳; 八木 利恭; 古旗 賢二; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Mar. 2016, 日本薬学会年会要旨集, 136年会, 3, 125, 125
• メトトレキサートによるJAK2V617F変異体発現細胞のアポトーシス誘導機構, 四元 佑樹; 内原 脩貴; 上田 史仁; 多胡 憲治; 多胡 めぐみ; 田村 悦臣, Mar. 2016, 日本薬学会年会要旨集, 136年会, 3, 131, 131
• IL-33前駆体は、がん化型Ras変異体が誘導する形質転換とサイクリンD1のタンパク質合成に必須の役割を担う, 太田 聡; 多胡 憲治; 多胡 めぐみ; 松儀 実広; 柳澤 健, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0110], [1P0110]
• Gαsユビキチン修飾を制御する分子機構の解析, 鯉森 貴行; 西村 基喜; 竹田 浩之; 多胡 憲治; 小林 哲夫; 澤崎 達也; 伊東 広, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2T21, 03(2P0180)]
• 新規IL-33シグナル調節蛋白質IFITM3の同定, 多胡 憲治; 多胡 めぐみ; 太田 聡; 松儀 実広; 柳澤 健, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2T21p, 04(2P0198)]
• 慢性骨髄増殖性腫瘍の原因遺伝子産物JAK2V617F変異体が誘導する形質転換におけるDDX5の役割, 安積 尊; 上田 史仁; 多胡 憲治; 柳澤 健; 多胡 めぐみ; 田村 悦臣, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [3P0187], [3P0187]
• 脂肪細胞分化におけるRNA helicase DDX5の役割, 近藤 駿介; 野間 瞭太; 上田 史仁; 多胡 めぐみ; 多胡 憲治; 柳澤 健; 中澤 洋介; 田村 悦臣, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [3P0192], [3P0192]
• Rho特異的活性化因子PLEKHG2のGαsとの相互作用による制御機構, 杉山 和恵; 多胡 憲治; 武藤 吉徳; 長瀬 隆弘; 上田 浩, Dec. 2015, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [3P0197], [3P0197]
• がん化型Ras変異体はNF-κBの過剰な活性化を引き起こす, 多胡 憲治; 多胡 めぐみ; 太田 聡; 松儀 実広; 柳澤 健, Oct. 2014, 日本生化学会大会プログラム・講演要旨集, 87回, [4T14a, 14]
• 脂肪細胞分化におけるRNA helicase DDX5の役割, 野間 瞭太; 多胡 めぐみ; 多胡 憲治; 柳沢 健; 田村 悦臣, Oct. 2014, 日本生化学会大会プログラム・講演要旨集, 87回, [4P, 306]
• 生物系薬学 ヒアルロン酸ががんの発症を抑制する, 多胡 憲治, Mar. 2014, 50, 3, 249, 249
• 心筋細胞のGタンパク質シグナルにおけるRic-8Bの機能(Involvement of Ric-8B in Gs suppression by Gq signal in cardiac myocytes), Jenie Riris I; 仲矢 道雄; 水野 憲一; 多胡 憲治; 黒瀬 等; 伊東 広, Sep. 2013, 日本生化学会大会プログラム・講演要旨集, 86回, 1T19p, 13
• がん化型Ras変異体が誘起する発がんシグナルはTNFαによるNF-κBの活性化を増強する(Oncogenic signal caused by Ras(G12V) augments the TNFα-induced activation of NF-κB), 多胡 憲治; 多胡 めぐみ; 太田 聡; 松儀 実広; 柳澤 健, Sep. 2013, 日本生化学会大会プログラム・講演要旨集, 86回, 3T13p, 11
• 慢性骨髄増殖性腫瘍由来JAK2変異体のがん化シグナルにおけるc-Myc-ODC経路の役割, 多胡 めぐみ; 鷲見 和也; 多胡 憲治; 笠原 忠, Dec. 2012, 日本生化学会大会プログラム・講演要旨集, 85回, 3P, 586
• 低分子量G蛋白質κB-RasはRas(G12V)による発がんシグナルに関与する, 多胡 憲治; 多胡 めぐみ; 柳澤 健; 杉山 直之; 冨田 勝; 水野 憲一; 伊東 広, Dec. 2012, 日本生化学会大会プログラム・講演要旨集, 85回, 3P, 614
• JAK2 V617F mutation causes cytokine-independent growth and tumorigenesis - Roles of STAT5 and c-Myc, T. Kasahara; M. Funakoshi-Tago; K. Tago, Sep. 2012, CYTOKINE, 59, 3, 539, 539, Summary international conference

  DOI
• 細胞のがん化におけるIL‐33の役割の解析, 太田聡; 多胡憲治; 多胡めぐみ; 松儀実広; 柳澤健, 2012, 日本分子生物学会年会プログラム・要旨集(Web), 35th, 3P-0461 (WEB ONLY)
• 微小管結合タンパク質doublecortinのPKAによるリン酸化を介した新規アクチン骨格制御, 鳥山 真奈美; 猪口 徳一; 深見 岳史; 多胡 憲治; 水野 憲一; 伊東 広, Sep. 2011, 日本生化学会大会プログラム・講演要旨集, 84回, 4P, 0342
• Gタンパク質シグナルにより制御されるSUMO化とその分子機構の解析, 多胡 憲治; 多胡 めぐみ; Chiocca Susanna; 水野 憲一; 伊東 広, Sep. 2011, 日本生化学会大会プログラム・講演要旨集, 84回, 4T10p, 7
• IL-33/ST2シグナル伝達系におけるJAK2の役割について, 笠原 忠; 多胡 めぐみ; 上四元 純; 村上 はるか; 多胡 憲治, Mar. 2011, 日本薬学会年会要旨集, 131年会, 3, 156, 156
• Doublecortin orchestrates microtubule and actin dynamics to promote neuronal progenitor cell migration in a manner dependent on phosphorylation by PKA., M. Toriyama; N. Mizuno; T. Iguchi; M. Toriyama; T. Fukami; K. Tago; H. Itoh, 2011, MOLECULAR BIOLOGY OF THE CELL, 22, Summary international conference
• Rab33a stimulates vesicular trafficking and promotes axon outgrowth., H. Nakazawa; T. Sada; M. Toriyama; K. Tago; M. Fukuda; N. Inagaki, 2011, MOLECULAR BIOLOGY OF THE CELL, 22, Summary international conference
• 大脳皮質形成における神経前駆細胞移動のGタンパク質シグナルによる多重制御機構, 水野 憲一; 鳥山 真奈美; 多胡 憲治; 伊東 広, Dec. 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 1T9, 3
• 三量体Gタンパク質Gαsのユビキチン化はRic-8Bとの結合により抑制される, 永井 裕介; 西村 明幸; 多胡 憲治; 水野 憲一; 伊東 広, Sep. 2009, 日本生化学会大会プログラム・講演要旨集, 82回, 4T4a, 8
• Gタンパク質シグナルによるdoublecortinのリン酸化と細胞遊走の解析, 吉田 真奈美; 水野 憲一; 多胡 憲治; 伊東 広, Sep. 2009, 日本生化学会大会プログラム・講演要旨集, 82回, 2P, 690
• 大脳皮質形成異常疾患に関連するGタンパク質共役型受容体GPR56の機能解析, 猪口 徳一; 坂田 賢成; 吉崎 幸太郎; 多胡 憲治; 水野 憲一; 伊東 広, Jun. 2009, 解剖学雑誌, 84, 2, 55, 55
• 活性酸素産生を司るRac-GEFであるP-Rex1のPKAによる抑制機構, 浦野 大輔; 中田 飛鳥; 水野 憲一; 多胡 憲治; 伊東 広, Nov. 2008, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回, 1T14, 3
• TNF-αシグナル伝達におけるcelecoxibの作用について, 清水 妙子; 多胡 めぐみ; 園田 よし子; 中村 元洋; 多胡 憲治; 伊東 広; 笠原 忠, Mar. 2008, 日本薬学会年会要旨集, 128年会, 3, 81, 81
• Licochalcone AのTNFα誘導性NF-κBの活性化に及ぼす影響, 田辺 沙詠子; 多胡 めぐみ; 園田 よし子; 笠原 忠; 岩田 進; 中村 元洋; 多胡 憲治; 伊東 広, Mar. 2008, 日本薬学会年会要旨集, 128年会, 3, 83, 83
• 神経前駆細胞の自己複製能および細胞増殖能におけるGPR56の機能解析, 永野孝典; 猪口徳一; 多胡憲治; 水野憲一; 伊東広, 2008, 生化学, 2P-1086
• 非定型低分子量GTPase κB-Rasの動的細胞内局在と発癌シグナルへの関与可能性(Dynamic subcellular localization of atypical small GTPase kappaB-Ras and its possible contribution to oncogenic signals), 多胡 憲治; 多胡 めぐみ; 水野 憲一; 笠原 忠; 富永 眞一; 伊東 広, Nov. 2007, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 80回・30回, 3T15, 4
• GPR56はG12/13とRhoを介して神経前駆細胞の遊走を制御する(GPR56 regulates neural progenitor cell migration through G12/13 and Rho), 猪口 徳一; 坂田 賢成; 吉崎 幸太郎; 多胡 憲治; 水野 憲一; 伊東 広, Nov. 2007, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 80回・30回, 3T15, 10
• IL-1シグナル伝達経路におけるc-Srcの役割, 多胡 めぐみ; 多胡 憲治; 園田 よし子; 富永 眞一; 笠原 忠, Aug. 2002, 生化学, 74, 8, 947, 947
• Effects of a novel splice variant of mouse interleukin (IL)-1 receptor-associated kinase-1 (IRAK1) on IL-1 signaling pathway., K Yanagisawa; K Tago; S Tominaga, Mar. 2002, FASEB JOURNAL, 16, 5, A1179, A1180, Summary international conference
• IL-1受容体関連ST2遺伝子産物の細胞内情報伝達系の解析, 多胡 憲治, Dec. 2001, 自治医科大学紀要, 24, 124, 124
• IRAK-1の選択的スプライシングバリアントの発現と機能, 柳沢 健; 多胡 憲治; 早川 盛禎; 岩花 弘之; 富永 眞一, Aug. 2001, 生化学, 73, 8, 731, 731
• マウスT細胞におけるST2遺伝子の発現調節, 早川 盛禎; 柳沢 健; 多胡 憲治; 岩花 弘之; 富永 眞一, Aug. 2001, 生化学, 73, 8, 706, 706
• 大腸癌由来細胞株におけるST2遺伝子の発現とその制御, 多胡 憲治; 早川 盛禎; 柳澤 健; 岩花 弘之; 富永 眞一, Aug. 2001, 生化学, 73, 8, 707, 707
• NF-κB抑制因子κB-Ras2の細胞内局在の解析, 船越 めぐみ; 多胡 憲治; 園田 よし子; 富永 眞一; 笠原 忠, Aug. 2001, 生化学, 73, 8, 865, 865
• ニワトリST2遺伝子のゲノム構造とその発現について, 岩花 弘之; 早川 盛禎; 多胡 憲治; 柳沢 健; 富永 眞一, Aug. 2001, 生化学, 73, 8, 1056, 1056
• A MEK inhibitor, PD98059 enhances IL-1-induced NF-kB activation by the enhance and sustained degradation of IkBa, T Kasahara; M Funakoshi; Y Sonoda; K Tago, 2001, JOURNAL OF LEUKOCYTE BIOLOGY, 34, 34, Summary international conference
• NF-κB活性調節機構におけるMAPキナーゼの役割, 船越 めぐみ; 多胡 憲治; 園田 よし子; 富永 眞一; 笠原 忠, Aug. 2000, 生化学, 72, 8, 1030, 1030
• ST2の新規splicing variant,ST2Vは細胞膜表面に局在する, 多胡 憲治; 黒岩 憲二; 李 紅杰; 柳沢 健; 岩花 弘之; 富永 眞一, Aug. 2000, 生化学, 72, 8, 1030, 1030
• ST2LV:ST2遺伝子産物の新しいバリアントについて, 岩花 弘之; 早川 盛禎; 柳沢 健; 多胡 憲治; 黒岩 憲二; 芳賀 靖; 増沢 紀男; 野地 澄晴; 冨永 眞一, Aug. 2000, 生化学, 72, 8, 1031, 1031
• ST2LV: A novel variant form of interleukin-1 receptor-related ST2 gene product., H Iwahana; K Yanagisawa; K Kuroiwa; K Tago; K Haga; T Masuzawa; S Noji; S Tominaga, Apr. 2000, FASEB JOURNAL, 14, 6, A1081, A1081, Summary international conference
• 増殖刺激時のBALB/c-3T3細胞における血管内皮細胞増殖因子のprimary responseによる発現, 柳沢 健; 黒岩 憲二; 多胡 憲治; 岩花 弘之; 内田 広夫; 富永 眞一, Dec. 1999, 自治医科大学紀要, 22, 87, 94
• モノクローナル抗体によるヒトST2タンパク質の検出及び,定量法の確立, 黒岩憲二; 新井孝夫; 小松則夫; LI H; 柳沢健; 岩花弘之; 多胡憲治; 富永真一, 22 Nov. 1999, 日本分子生物学会年会プログラム・講演要旨集, 22nd, 687
• ニワトリST2遺伝子の胎生期における発現, 岩花 弘之; 柳沢 健; 多胡 憲治; 黒岩 憲二; 芳賀 靖; 増沢 紀男; 野地 澄晴; 富永 眞一, Aug. 1999, 生化学, 71, 8, 942, 942
• SixとEyaとの協同作用が標的遺伝子の活性化に必要である, 大戸 裕美; 鎌田 さやか; 多胡 憲治; 富永 真一; 尾崎 秀徳; 佐藤 滋; 川上 潔, Aug. 1999, 生化学, 71, 8, 949, 949
• ヒト膜在型ST2 cDNAのクローニングと組織における発現, 李 紅杰; 柳沢 健; 黒岩 憲二; 多胡 憲治; 岩花 弘之; 新井 孝夫; 富永 眞一, Aug. 1999, 生化学, 71, 8, 1058, 1058
• IL-1刺激によるヒトグリオーマ細胞株T98GでのIL-8産生誘導におけるTRAF6の関与について, 船越 めぐみ; 多胡 憲治; 富永 真一; 園田 よし子; 笠原 忠, Aug. 1999, 生化学, 71, 8, 1073, 1073
• マウス線維芽細胞BALB/c-3T3におけるVEGFの発現様式, 柳沢 健; 多胡 憲治; 岩花 弘之; 富永 眞一, Aug. 1998, 生化学, 70, 8, 977, 977
• IL-3情報伝達系におけるSosタンパク質の機能の解析, 多胡 憲治, Jul. 1996, 生化学, 68, 7, 828, 828
• スタウロスポリンとマストパランの三量体G蛋白質への作用様式の比較, 多胡 憲治, Aug. 1993, 生化学, 65, 8, 833, 833

Awards

• Jan. 2012

Research Projects

• 01 Apr. 2022, 31 Mar. 2025, 22K06131

  対象リソースIRI
• Analysis of nuclear signaling complexes of novel Ras family and their activities to induce cellular transformation, Tago Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Jichi Medical University, 01 Apr. 2017, 31 Mar. 2020, In this research project, we attempted to clarify the role of small GTPase NKiRas in the oncogenic signals. In the previous study, we concluded that NKiRas possesses the essential roles in Ras (G12V)-induced carcinogenic signals. Recently, we found that NKiRas is required for the expression of Slc14A1, a target gene of Ras-induced oncogenic signals. Interestingly, the expression of Slc14A1 was drastically suppressed by the enforced expression of TRB3, which we identified as a interacting protein of NKiRas. Taken together, it is suggested that TRB3 exhibits its tumor-suppressor activity mediated by suppressing NKi-Ras. In future project, we need to clarify the role of Slc14A1 in oncogenic signals., 17K07343

  対象リソースIRI
• Analysis of oncogenic signals regulated by novel type of Ras family protein, Tago Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Jichi Medical University, 01 Apr. 2014, 31 Mar. 2017, It is well established that genetic mutations of Ras genes are involved in many cases of tumorigenesis. In this study, we found that a member of Ras family, kappaB-Ras contributes to the cellular transformation mediated the activation of protein kinase mTORC1. Furthermore, we purified the protein complexes including kappaB-Ras, and found that TRB3 which is identified as an interacting protein of kappaB-Ras functions as novel type of tumor suppressor. Although detailed mechanism is still unclear, it is clarified that TRB3 suppresses the oncogenic signals mediated the SUMO-conjugation of kappaB-Ras., 26440062

  対象リソースIRI
• Investigation on inhibitory mechanism of soluble ST2 protein (secreted IL-33 receptor) against LPS signal, Yanagisawa Ken, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Jichi Medical University, 01 Apr. 2014, 31 Mar. 2017, We investigated the mechanism of inhibitory effect of soluble ST2 protein, which is the extracellular domain of IL-33 receptor (ST2L protein), against the LPS signal transduction. ST2 protein did not inhibit the binding of LPS with LPS receptor. Each component of LPS receptor complex, TLR 4, CD14 and MD2, did not show the binding with ST2 protein, and each combination of two components of above also failed to bind with ST2, which suggests higher structure of LPS receptor complex is required for the binding with ST2. Furthermore, We found novel proteins such as IFITM3 which bind with ST2L protein, and IL-33 is indispensable for the cellular transformation by Ras independent of ST2 protein, and IL-33 promotes the translation of cyclin D., 26460376

  対象リソースIRI
• Study on the mechanism of cell growth regulation by ST2 and its possible anti-cancerous effect., Tominaga Shin-ichi; TAGO KENJI, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Jichi Medical University, 01 Apr. 2013, 31 Mar. 2016, The ST2 gene was originally identified as a gene induced during the initiation of cell proliferation. Since the products had a sequence very similar to the interleukin 1 receptor and IL-33 was found as a ligand inducing inflammatory responses, the major concern has been immunological aspect. In the present study, coming back to the original findings, we investigated the roles of IL-33 and ST2 in cell proliferation of NIH-3T3 fibroblastic cell line. IL-33 had dual functions, namely, a suppressive effect on the growth initiation of quiescent cells, and a growth-promoting effect on cycling cells. On the other hand, contrary to the initial hypothesis, soluble ST2 had a growth-promoting effect. The relationship between IL-33 and ST2 in terms of growth regulation remains to be elucidated in future., 25460393

  対象リソースIRI
• Functional analysis of an atypical nuclear small GTPase in the oncogenic signal, TAGO Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), 2011, 2013, kappaB-Ras is a nuclear-cytoplasmic GTPase that mainly present as GTP-bound form with no stimulating conditions, and its cellular localization is regulated by its bound guanine nucleotides. Here, we found that kappaB-Ras is essential for Ras (G12V)-induced tumorigenesis, although kappaB-Ras itself lacks the oncogenic activities. To clarify the mechanism, by which kappaB-Ras is involved in Ras (G12V)-caused tumorigenesis, we purified the protein complexes including kappaB-Ras2, and identified novel interacting proteins of kappaB-Ras, such as TRB3 and DDB1. TRB3 exhibited the tumor suppressive activity against Ras (G12V). Furthermore, TRB3 induced SUMOylation of kappaB-Ras, and this seems to cause the inhibition of Ras (G12V)-induced transformation. These observations suggest that kappaB-Ras harbors the critical roles in tumorigenesis induced by oncogenic Ras, and this is most likely to be regulated by novel tumor suppressor TRB3 through the SUMOylation of kappaB-Ras., 23570166

  対象リソースIRI
• Analysis of the novel family of G protein-coupled receptor, ITOH Hiroshi; MIZINO Norikazu; TAGO Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Nara Institute of Science and Technology, 2009, 2011, Adhesion G protein-coupled receptors(GPCRs) have a long N-terminal extracellular domain and a seven-transmembrane domain. Most of adhesion GPCRs are orphan receptors, and the activation and signal transduction mechanisms remain to be clarified. GPR56 and Latrophilin1 belong to adhesion GPCRs. We succeed in preparing the monoclonal antibody against human GPR56, which inhibits the glioma cell migration, and have constructed several mutants. Analysis using mutants showed that an extracellular domain of Latrophilin1 has an ability to inhibit the activation of Latrophilin1 transmembarane domain as well as the GPR56 transmembrane activation., 21370056

  対象リソースIRI
• Functional analysis of atypical nuclear small GTP-binding protein, TAGO Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Nara Institute of Science and Technology, 2008, 2009, We found that κB-Ras is a novel type of nuclear-cytoplasmic small GTPase that mainly binds to GTP, and its localization seemed to be regulated by its GTP/GDP-binding state. Unexpectedly, the GDP-binding form of κB-Ras mutant exhibited a more potent inhibitory effect on NF-κB activation, and this inhibitory effect seemed to be due to suppression of the transactivation of a p65/RelA NF-κB subunit., 20770103

  対象リソースIRI
• Identification and analysis of new molecules that regulate G protein signaling, ITOH Hiroshi; MIZUNO Norikazu; TAGO Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, Grant-in-Aid for Scientific Research on Priority Areas, Nara Institute of Science and Technology, 2005, 2009, In this study, we found that orphan G protein-coupled receptor, GPR56, negatively regulates neural progenitor cell migration via G12/13 and Rho pathway, and the antibody which recognizes the orphan receptor is an useful tool for analyzing the function of the receptor. Moreover, structural basis for the specific inhibition of G proteins by YM-254890 has been revealed by biochemical and X-ray crystal structure analysis. Ubiquitination of the stimulatory G protein ・ subunit and its inhibition by Ric-8B was demonstrated. Crosstalk between G protein signaling and dioxin signaling was found by identifying AIP as a novel G protein interacting protein., 17079006

  対象リソースIRI
• Functional analysis of a novel type of G protein-coupled receptor, ITOH Horoshi; MIZINO Norikazu; TAGO Kenji, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Nara Institute of Science and Technology, 2007, 2008, 19370055

  対象リソースIRI