Researcher Profile and Settings

Affiliation

• Biochemistry, Professor

Profile and Settings

• Name

  Minamishima, Andrew, Yoji Andrew

• Foreign name

  Yoji Andrew Minamishima

Alternate Names

• Yoji Andrew Minamishima
• 南嶋 洋司
• MINAMISHIMA Yohji
• YA Minamishima
• Yoji Andy Minamishima
• MINAMISHIMA Youji
• Yohji A Minamishima
• Andrew Minamishima Yoji
• Minamishima Yoji Andrew
• 南島 洋司
• Yohji A. Minamishima
• Yohji Minamishima
• Minamishima YA
• Minamishima Y A
• Yoji A. Minamishima
• MINAMISHIMA Yoji-Andrew
• 南嶋洋司

ホームページ

• URI

  http://orcid.org/0000-0001-7995-9318, ORCID

• URI

  http://researchmap.jp/minamishima/, Researchmap

• URI

  http://biochemistry.med.gunma-u.ac.jp, Lab HP

Foreign language

• Use in presentation

  English

• Use in publication

  English

Affiliation

• Professor, Department of Biochemistry, Gunma University Graduate School of Medicine

Affiliation

• Affiliation

  Graduate School of Medicine, Biochemistry

• Job title

  Professor

Education

• Apr. 1987, Mar. 1993, Kyushu University School of Medicine, Department of Medicine
• Apr. 1998, Mar. 2002, Kyushu University, Graduate School of Medical Science

Degree

• M.D.
• Ph.D.
• M.D.
• Ph.D.
• M.D.
• M.D., Kyushu University, Mar. 1993
• Ph.D., Kyushu University, Mar. 2002

Association Memberships

• JAPAN SURGICAL SOCIETY, 1993, 1998
• THE JAPANESE SOCIETY OF GASTROENTEROLOGICAL SURGERY, 1993, 1998
• JAPAN SURGICAL ASSOCIATION, 1993, 1998
• The Molecular Biology Society of Japan, 1998, 9999
• American Association for Cancer Research, 2002, 2004
• The Japanese Biochemical Society, 2011, 9999

  対象リソースIRI
• THE JAPANESE CANCER ASSOCIATION, 2015, 9999
• THE JAPANESE PHARMACOLOGICAL SOCIETY, 2016, 2019
• THE PHYSIOLOGICAL SOCIETY OF JAPAN, 2017, 2019

Research Experience

• Apr. 1993, May 1994, Resident, Department of Surgery 1, Kyushu University Hospital
• Jun. 1994, May 1995, Resident, Department of Surgery, Kyushu Kosei Nenkin Hospital, Expert etc
• Jun. 1995, May 1996, Fellow, Department of Surgery, Miyazaki Prefectural Miyazaki Hospital, Expert etc
• Jun. 1996, Mar. 1998, Fellow, Department of Surgery, Fukuoka Red Cross Hospital, Expert etc
• Apr. 1998, Mar. 2002, Grad Student, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Others
• Sep. 2004, Aug. 2010, Research Fellow, Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Researcher postdoc lv
• Apr. 2002, Sep. 2004, Research Fellow, Beth Israel Deaconess Medical Center, Harvard Medical School, Researcher postdoc lv
• Sep. 2010, Mar. 2016, Group Leader, ERATO, Japan Science and Technology Agency (JST), Research admin
• Sep. 2010, Mar. 2016, Assistant Professor, Department of Biochemistry, Keio University School of Medicine, Assistant prof lv
• Apr. 2016, Nov. 2018, Project Associate Professor, Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Associate prof lecturer lv
• Dec. 2018, 9999, Professor, Department of Biochemistry, Gunma University Graduate School of Medicine, Prof lv

Research Activities

Research Areas

• Life sciences, Molecular biology
• Life sciences, Cell biology
• Life sciences, Medical biochemistry
• Life sciences, Pathobiochemistry

Research Interests

• Cellular senescence
• Cell cycle
• Hydrogen sulfide
• Metabolism
• Cancer biology
• Hypoxia

Published Papers

• Development of drugs targeting hypoxia-inducible factor against tumor cells with VHL mutation: Story of 127 years, Takamori, Hajime;Yamasaki, Toshinari;Kitadai, Rui;Minamishima, Yoji Andrew;Nakamura, Eijiro, 2023, Cancer science, 114, 4, 1208, 1217, Scientific journal

  DOI
• Down-regulation of p27(Kip1) expression is required for development and function of T cells, Tsukiyama, T;Ishida, N;Shirane, M;Minamishima, YA;Hatakeyama, S;Kitagawa, M;Nakayama, K;Nakayama, K, 2001, JOURNAL OF IMMUNOLOGY, 166, 1, 304, 312
• Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3., Kiyozuka Keisuke;Zhao Xian;Konishi Akimitsu;Minamishima Yoji Andrew;Obinata Hideru, Apr. 2023, Journal of biochemistry, Scientific journal

  DOI
• Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1., Zhao Xian;Kiyozuka Keisuke;Konishi Akimitsu;Kawabata-Iwakawa Reika;Minamishima Yoji Andrew;Obinata Hideru, May 2023, The Journal of biological chemistry, Scientific journal

  DOI
• Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli., Hirakawa Hidetada;Takita Ayako;Sato Yumika;Hiramoto Suguru;Hashimoto Yusuke;Ohshima Noriyasu;Minamishima Yoji A;Murakami Masami;Tomita Haruyoshi, May 2023, Microbiology spectrum, Scientific journal

  DOI
• Inactivation of ackA and pta Genes Reduces GlpT Expression and Susceptibility to Fosfomycin in Escherichia coli, Hidetada Hirakawa; Ayako Takita; Yumika Sato; Suguru Hiramoto; Yusuke Hashimoto; Noriyasu Ohshima; Yoji A. Minamishima; Masami Murakami; Haruyoshi Tomita, 18 May 2023, Microbiology Spectrum, Scientific journal

  DOI
• Apolipoprotein M supports S1P production and conservation and mediates prolonged Akt activation via S1PR1 and S1PR3., Keisuke Kiyozuka; Xian Zhao; Akimitsu Konishi; Yoji Andrew Minamishima; Hideru Obinata, 25 Apr. 2023, Journal of biochemistry, Scientific journal

  DOI
• Development of drugs targeting hypoxia-inducible factor against tumor cells with VHL mutation: Story of 127 years, Hajime Takamori; Toshinari Yamasaki; Rui Kitadai; Yoji Andrew Minamishima; Eijiro Nakamura, Apr. 2023, Cancer science, 114, 4, 1208, 1217

  DOI
• LTBP2 is a novel marker in hepatocellular carcinoma, Bilguun Erkhem-Ochir; Barbara Chivarina; Takehiko Yokobori; Evgenia Turtoi; Hideru Obinata; Gombodorj Navchaa; Yoji Andrew Minamishima; Toshiyuki Matsuzaki; Hiroshi Saeki; Masahiko Nishiyama; Ken Shirabe; Andrei Turtoi, Feb. 2021, Cancer science, 112, 755, 755
• Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Hiroaki Kikuchi; Emi Sasaki; Naohiro Nomura; Takayasu Mori; Yoji Andrew Minamishima; Yuki Yoshizaki; Naohiro Takahashi; Taisuke Furusho; Yohei Arai; Shintaro Mandai; Takahiro Yamashita; Fumiaki Ando; Yasuhiro Maejima; Kiyoshi Isobe; Tomokazu Okado; Tatemitsu Rai; Shinichi Uchida; Eisei Sohara, Jan. 2019, Kidney international, 95, 1, 123, 137, Scientific journal

  DOI
• Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment, Tomoko Oyaizu-Toramaru; Tomohiro Suhara; Noriyo Hayakawa; Takashi Nakamura; Akiko Kubo; Shizuka Minamishima; Kyoji Yamaguchi; Takako Hishiki; Hiroshi Morisaki; Makoto Suematsu; Yoji Andrew Minamishima, Aug. 2017, Molecular and cellular biology, 37, 16, Scientific journal

  DOI
• Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis, Tomoko Oyaizu-Toramaru; Tomohiro Suhara; Noriyo Hayakawa; Takashi Nakamura; Shizuka Minamishima; Akiko Kubo; Kyoji Yamaguchi; Takako Hishiki; Hiroshi Morisaki; Makoto Suematsu; Yoji Andrew Minamishima, Mar. 2017, Journal of pharmacological sciences, 133, 3, S101, S101
• Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules, Koji Futatsugi; Hirobumi Tokuyama; Shinsuke Shibata; Makiko Naitoh; Takeshi Kanda; Hitoshi Minakuchi; Shintaro Yamaguchi; Koichi Hayashi; Yoji Andrew Minamishima; Motoko Yanagita; Shu Wakino; Hiroshi Itoh, Nov. 2016, Scientific reports, 6, Scientific journal

  DOI
• Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation, Nobuyuki Tanaka; Takeo Kosaka; Yasumasa Miyazaki; Shuji Mikami; Naoya Niwa; Yutaro Otsuka; Yoji Andrew Minamishima; Ryuichi Mizuno; Eiji Kikuchi; Akira Miyajima; Hisataka Sabe; Yasunori Okada; Per Uhlen; Makoto Suematsu; Mototsugu Oya, Nov. 2016, Jci insight, 1, 18, Scientific journal

  DOI
• Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle, Tomohiro Suhara; Takako Hishiki; Masataka Kasahara; Noriyo Hayakawa; Tomoko Oyaizu; Tsuyoshi Nakanishi; Akiko Kubo; Hiroshi Morisaki; William G. Kaelin; Makoto Suematsu; Yoji Andrew Minamishima, Sep. 2015, Proceedings of the national academy of sciences of the united states of america, 112, 37, 11642, 11647, Scientific journal

  DOI
• Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1 beta and regulates the cellular PDH activity, Daisuke Kikuchi; Yoji Andrew Minamishima; Koh Nakayama, Aug. 2014, Biochemical and biophysical research communications, 451, 2, 288, 294, Scientific journal

  DOI
• Energy management by enhanced glycolysis in g(1)-phase in human colon cancer cells in vitro and in vivo, Yan Bao; Kuniaki Mukai; Takako Hishiki; Akiko Kubo; Mitsuyo Ohmura; Yuki Sugiura; Tomomi Matsuura; Yoshiko Nagahata; Noriyo Hayakawa; Takehiro Yamamoto; Ryo Fukuda; Hideyuki Saya; Makoto Suematsu; Yoji Andrew Minamishima, Sep. 2013, Molecular cancer research, 11, 9, 973, 985, Scientific journal

  DOI
• Acute HIF prolyl hydroxylase 2 inactivation confers protection against myocardial ischemic reperfusion injury, Steven M. Bair; Yoji A. Minamishima; Ronglih Liao; William G. Kaelin; Javid Moslehi, Nov. 2011, Circulation, 124, 21
• Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1, Wenchu Lin; Jian Cao; Jiayun Liu; Michael L. Beshiri; Yuko Fujiwara; Joshua Francis; Andrew D. Cherniack; Christoph Geisen; Lauren P. Blair; Mike R. Zou; Xiaohua Shen; Dan Kawamori; Zongzhi Liu; Chiara Grisanzio; Hideo Watanabe; Yoji Andrew Minamishima; Qing Zhang; Rohit N. Kulkarni; Sabina Signoretti; Scott J. Rodig; Roderick T. Bronson; Stuart H. Orkin; David P. Tuck; Elizaveta V. Benevolenskaya; Matthew Meyerson; William G. Kaelin; Qin Yan, Aug. 2011, Proceedings of the national academy of sciences of the united states of america, 108, 33, 13379, 13386, Scientific journal

  DOI
• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy, Javid Moslehi; Yoji Andrew Minamishima; Jianru Shi; Donna Neuberg; David M. Charytan; Robert F. Padera; Sabina Signoretti; Ronglih Liao; William G. Kaelin, Sep. 2010, Circulation, 122, 10, 1004, U108, Scientific journal

  DOI
• Loss of PHD prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy, Javid Moslehi; Yoji Andy Minamishima; Robert Padera; Ronglih Liao; William G. Kaelin, Aug. 2010, Journal of cardiac failure, 16, 8, S2, S2

  DOI
• Reactivation of hepatic EPO synthesis in mice after PHD loss, Yoji Andrew Minamishima; William G. Kaelin, Jul. 2010, Science, 329, 5990, 407, 407, Scientific journal

  DOI
• A feedback loop involving the phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo, Yoji Andrew Minamishima; Javid Moslehi; Robert F. Padera; Roderick T. Bronson; Ronglih Liao; William G. Kaelin, Nov. 2009, Molecular and cellular biology, 29, 21, 5729, 5741, Scientific journal

  DOI
• Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-Dependent mechanism in mice, Shizuka Minamishima; Masahiko Bougaki; Patrick Y. Sips; Jia De Yu; Yoji Andrew Minamishima; John W. Elrod; David J. Lefer; Kenneth D. Bloch; Fumito Ichinose, Sep. 2009, Circulation, 120, 10, 888, U132, Scientific journal

  DOI
• Hydrogen sulfide improves outcome after cardiac arrest and cardiopulmonary resuscitation in mouse, Shizuka Minamishima; Jia De Yu; Masahiko Bougaki; Christophe Adrie; Yoji A. Minamishima; David J. Lefer; Fumito Ichinose, Oct. 2008, Circulation, 118, 18, S1446, S1447
• Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure, Yoji Andrew Minamishima; Javid Moslehi; Nabeel Bardeesy; Darragh Cullen; Roderick T. Bronson; William G. Kaelin, Mar. 2008, Blood, 111, 6, 3236, 3244, Scientific journal

  DOI
• VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400, Arthur P. Young; Susanne Schlisio; Yoji Andrew Minamishima; Qing Zhang; Lianjie Li; Chiara Grisanzio; Sabina Signoretti; William G. Kaelin, Mar. 2008, Nature cell biology, 10, 3, 361, U115, Scientific journal

  DOI
• pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappa B agonist Card9 by CK2, Haifeng Yang; Yoji Andrew Minamishima; Qin Yan; Susanne Schlisio; Benjamin L. Ebert; Xiaoping Zhang; Liang Zhang; William Y. Kim; Aria F. Olumi; William G. Kaelin, Oct. 2007, Molecular cell, 28, 1, 15, 27, Scientific journal

  DOI
• Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations, Lianjie Li; Liang Zhang; Xiaoping Zhang; Qin Yan; Yoji Andrew Minamishima; Aria F. Olumi; Mao Mao; Steven Bartz; William G. Kaelin, Aug. 2007, Molecular and cellular biology, 27, 15, 5381, 5392, Scientific journal

  DOI
• Skp2-Mediated degradation of p27 regulates progression into mitosis, Keiko Nakayama; Hiroyasu Nagahama; Yohji A. Minamishima; Satoshi Miyake; Noriko Ishida; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Shun ichiro Iemura; Tohru Natsume; Keiichi I. Nakayama, May 2004, Developmental cell, 6, 5, 661, 672, Scientific journal

  DOI
• ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway, Takao Ohtsuka; Hoon Ryu; Yohji A. Minamishima; Salvador Macip; Junji Sagara; Keiichi I. Nakayama; Stuart A. Aaronson; Sam W. Lee, Feb. 2004, Nature cell biology, 6, 2, 121, 128, Scientific journal

  DOI
• Modulation of p53 and p73 levels by cyclin G: Implication of a negative feedback regulation, Takao Ohtsuka; Hoon Ryu; Yohji A. Minamishima; Akihide Ryo; Sam W. Lee, 20 Mar. 2003, Oncogene, 22, 11, 1678, 1687, Scientific journal

  DOI
• Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4, Michiyo Saimura; Eishi Nagai; Kazuhiro Mizumoto; Naoki Maehara; Yohji A. Minamishima; Mitsuo Katano; Kunio Matsumoto; Toshikazu Nakamura; Masao Tanaka, 01 Oct. 2002, Clinical cancer research, 8, 10, 3243, 3249, Scientific journal
• Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice, Yohji A. Minamishima; Keiko Nakayama; Kei Ichi Nakayama, Feb. 2002, Cancer research, 62, 4, 995, 999, Scientific journal
• Effect of serum depletion on centrosome overduplication and death of human pancreatic cancer cells after exposure to radiation, Masaki Shono; Norihiro Sato; Kazuhiro Mizumoto; Yohji A. Minamishima; Masafumi Nakamura; Naoki Maehara; Taro Urashima; Michiyo Saimura; Liwu Qian; Shoko Nishio; Eishi Nagai; Masao Tanaka, 10 Sep. 2001, Cancer letters, 170, 1, 81, 89, Scientific journal

  DOI
• Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells, Norihiro Sato; Kazuhiro Mizumoto; Masafumi Nakamura; Naoki Maehara; Yohji A. Minamishima; Shoko Nishio; Eishi Nagai; Masao Tanaka, Apr. 2001, Cancer genetics and cytogenetics, 126, 1, 13, 19, Scientific journal

  DOI
• Down-regulation of p27^Kip1 expression is required for development and function of T cells, Tadasuke Tsukiyama; Noriko Ishida; Michiko Shirane; Yohji A. Minamishima; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Keiko Nakayama; Kei-ichi Nakayama, 01 Jan. 2001, Journal of immunology, 166, 1, 304, 312, Scientific journal

  DOI
• A possible role for centrosome overduplication in radiation-induced cell death, Norihiro Sato; Kazuhiro Mizumoto; Masafumi Nakamura; Hikaru Ueno; Yohji A. Minamishima; John L. Farber; Masao Tanaka, 02 Nov. 2000, Oncogene, 19, 46, 5281, 5290, Scientific journal

  DOI
• Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice, Hiroyuki Takai; Kaoru Tominaga; Noboru Motoyama; Yohji A. Minamishima; Hiroyasu Nagahama; Tadasuke Tsukiyama; Kyoji Ikeda; Keiko Nakayama; Makoto Nakanishi; Kei Ichi Nakayama, 15 Jun. 2000, Genes and development, 14, 12, 1439, 1447, Scientific journal
• Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication, Keiko Nakayama; Hiroyasu Nagahama; Yohji A. Minamishima; Masaki Matsumoto; Ikuo Nakamichi; Kyoko Kitagawa; Michiko Shirane; Ryosuke Tsunematsu; Tadasuke Tsukiyama; Noriko Ishida; Masatoshi Kitagawa; Kei Ichi Nakayama; Shigetsugu Hatakeyama, 02 May 2000, EMBO journal, 19, 9, 2069, 2081, Scientific journal

  DOI
• Adenoma arising from the cystic duct and extending to the confluence of the extrahepatic biliary tract, Hiroshi Satoh; Tatsuya Hirano; Yoshiaki Ogawa; Yohji Minamishima; Shouichiro Saitoh; Masaki Takashima; Katsuaki Koga; Nobutoshi Imaizumi; Masahiko Yoshida, 1999, Journal of hepato-biliary-pancreatic surgery, 6, 2, 186, 189, Scientific journal

  DOI
• Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1, Xian Zhao; Keisuke Kiyozuka; Akimitsu Konishi; Reika Kawabata-Iwakawa; Yoji Andrew Minamishima; Hideru Obinata, Jul. 2023, Journal of biological chemistry, 299, 7, Scientific journal

  DOI
• Branched-chain amino acid metabolism is a crucial modulator of cellular senescence, Yuma Aramaki; Kazuki Irie; Hideru Obinata; Shinya Honda; Takuro Horii; Satoko Arakawa; Aiko Tsuchida; Junki Hoshino; Ryosuke Kobayashi; Takashi Izumi; Izuho Hatada; Shigeomi Shimizu; Yoji A. Minamishima; Akimitsu Konishi, 10 Sep. 2024

  DOI

MISC

• Molecular mechanism of HIF-PH inhibition and hypoxic response activation, 南嶋洋司, Aug. 2022, 腎と透析, 93, 2, 171, 177, Introduction scientific journal
• マウス由来GDE7は環状ホスファチジン酸を産生する酵素活性を有する, Tserendavga Binderiya; 大嶋 紀安; 藤田 千明; 湯澤 厚二; 大嶋 麻理; 矢中 規之; 南嶋 洋司; 和泉 孝志, May 2022, 脂質生化学研究, 64, 247, 249
• Hypoxic response as a therapeutic target of human diseases, Andrew Minamishima Yoji, 2020, Folia pharmacologica japonica, 155, 1, 40, 45

  DOI
• 恩師の2019年ノーベル医学生理学賞｢酸素濃度の感知と低酸素への適応｣受賞に寄せて : 弟子から見たDr. William "Bill" G. Kaelin Jr, 南嶋 洋司, Dec. 2019, 89, 12, 1137, 1140
• メトホルミン誘発乳酸アシドーシスに対する治療標的としてのOxygen-sensing prolyl hydroxylase(PHD)—Oxygen-sensing prolyl hydroxylase PHD as a therapeutic target of metformin-associated lactic acidosis (MALA), 南嶋 洋司, Sep. 2019, 49, 3, 218, 225
• 低酸素応答経路と疾患との関連—Clinical implication of the hypoxic response mechanism—50周年記念号 ; 特集 酸素生物学, 南嶋 洋司, Apr. 2018, 50, 4, 180, 183
• 低酸素応答とレドックスシグナル, 南嶋 洋司, 2018, 36, 5, 890, 895
• 低酸素応答による細胞内エネルギー代謝制御機構, 南嶋 洋司, 2018, 17, 3, 15, 22
• シン・メタボリズム〜代謝が関わる多彩な生命現象〜 老化・がん化耐性齧歯類ハダカデバネズミのエネルギー代謝を制御する分子機構の解析, 岡 香織; 大岩 祐基; 河村 佳見; 杉浦 悠毅; 南嶋 洋司; 末松 誠; 和氣 正樹; 武田 憲彦; 城戸 康年; 稲岡 健ダニエル; 北 潔; 三浦 恭子, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [2PW05, 4]
• 肝臓のエネルギー代謝 センシングと病態 低酸素応答メカニズムを標的としたメトホルミン関連乳酸アシドーシス(MALA)の新規治療法の開発, 南嶋 洋司; 小柳津 智子; 丸; 壽原 朋宏; 早川 典代; 中村 貴; 南嶋 しづか; 久保 亜紀子; 山口 京二; 菱木 貴子; 森崎 浩; 末松 誠, Apr. 2017, 糖尿病, 60, Suppl.1, S, 134, Summary national conference
• 低酸素応答による代謝制御とドラッグ・リポジショニング, 小柳津-寅丸 智子; 壽原 朋宏; 南嶋 洋司, 2017, 53, 3, 234, 237

  DOI
• 低酸素とがんの代謝, 南嶋 洋司, 2017, 35, 10, 1659, 1663
• Hypoxia and Disease 低酸素応答を標的とした各種疾患治療法の開発 致死的乳酸アシドーシスの新規治療法, 小柳津 智子; 寅丸; 壽原 朋宏; 早川 典代; 中村 貴; 南嶋 しづか; 山口 京二; 菱木 貴子; 森崎 浩; 末松 誠; 南嶋 洋司, Sep. 2016, 89回, [2S09, 4]
• Regulation of cellular energy metabolism by prolyl hydroxylase PHD, Minamishima Yoji Andrew, 25 Jun. 2016, 88, 3, 302, 307

  DOI
• 酸素濃度センサー分子・PHDによる細胞内代謝調節—Regulation of cellular energy metabolism by prolyl hydroxylase PHD—特集 代謝変化とエピジェネティクス制御, 南嶋 洋司, Jun. 2016, 88, 3, 302, 307
• 敗血症における乳酸の役割 低酸素応答は血中乳酸値を下げるか?, 南嶋 洋司, 2016, 40, 4, 599, 607
• メタボローム解析—Metabolomics and medical science, 南嶋 洋司; 久保 亜紀子, Aug. 2015, 2, 2, 203, 209
• 低酸素応答―細胞内エネルギー代謝の低酸素モードとは?, 南嶋 洋司, 2014, Vol.32-No.15, 15, 2397, 2403
• 成人肝細胞のエリスロポエチン産生能力再活性化と、その腎性貧血治療への応用, 南嶋 洋司; Kaelin Jr. William G.; 末松 誠, Dec. 2012, 35, 2, 112, 116
• 【低酸素のバイオロジー】エネルギー代謝異常疾患としての癌, 南嶋 洋司, Nov. 2012, 13, 4, 385, 391
• 【代謝、発生、免疫で動き出す低酸素応答システム】ノックアウトモデルからみたin vivo低酸素応答 発生、心臓・腎疾患、がんにおけるPHDの役割, 南嶋 洋司; 末松 誠, May 2012, 30, 8, 1270, 1275
• A case of transverse colon actinomycosis., Jimi S.; Minamishima Y.; Sato H.; Chijiiwa K.; Mibu R.; Tanaka M.; Ueki T., 1996, Nippon daicho komonbyo gakkai zasshi, 49, 5, 368, 372

  DOI
• 肺癌病理における腫瘍微小環境 肺癌微小環境での低酸素応答と腫瘍免疫, 南嶋 洋司, Nov. 2022, 62, 6, 510, 510
• 細胞内シグナルの開始・継続・終焉に働く多様なタンパク質分解機構 酸素濃度依存的プロリン水酸化とユビキチン-プロテアソーム系蛋白分解による低酸素応答の制御, 南嶋 洋司, Nov. 2022, 95回, 3S15m, 06
• General remarks Past and future of Hypoxic response research, 南嶋洋司, May 2022, 月刊細胞, 54, 7, 354, 355, Introduction scientific journal
• 低酸素応答分子メカニズムの臨床応用, 南嶋 洋司, Aug. 2021, 71, 3, 244, 244
• 血中スフィンゴシン1リン酸の産生および分解過程におけるキャリアタンパク質の役割, 清塚 啓介; Zhao Xian; 南嶋 洋司; 大日方 英, Sep. 2020, 93回, [1Z02, 055)]
• 敗血症に関する基礎研究-2 低酸素応答は敗血症の予後を改善させるか?, 壽原 朋宏; 伊原 奈帆; 南嶋 しづか; 寅丸 智子; 鈴木 悠太; 長田 大雅; 山田 高成; 南嶋 洋司; 森崎 浩, Sep. 2020, 27, Suppl., 280, 280
• 新しい腎性貧血治療薬としてのHIF-PHD阻害薬～これを聞けば全てが分かります～ HIF-PH阻害剤 低酸素応答が個体に与える影響, 南嶋 洋司, Jul. 2020, 62, 4, 238, 238
• BRCA1複合体による機能不全テロメアにおける細胞周期特異的なDNA損傷修復の制御機構(BRCA1 complex regulates cell cycle-dependent DNA damage repair at telomeres to maintain chromosome integrity), 小西 昭充; 南嶋 洋司, Sep. 2019, 日本癌学会総会記事, 78回, P, 3241
• 硫化水素解毒酵素sulfide-quinone oxidoreductaseの機能解析, 西村 明; 守田 匡伸; 南嶋 洋司; 井田 智章; 松永 哲郎; 藤井 重元; 本橋 ほづみ; 赤池 孝章, Jun. 2018, 43, Suppl., S298, S298
• 分子状酸素による遺伝子発現調節から紐解く疾患生物学 肥満に伴う腎障害における腎虚血とPHD2の役割, 脇野 修; 二木 功治; 徳山 博文; 内藤 真紀子; 南嶋 洋司; 伊藤 裕, Dec. 2017, 2017年度, [3PW08, 4]
• 分子状酸素による遺伝子発現調節から紐解く疾患生物学 低酸素環境下で酵素活性が低下するプロリン水酸化酵素PHDを標的とした、腎性貧血や乳酸アシドーシスなどの様々な疾患の治療法の開発, 南嶋 洋司, Dec. 2017, 2017年度, [3PW08, 5]
• 細菌から哺乳類に至るまで保存されている硫化水素代謝酵素Sqrdlの遺伝子改変マウスを用いた機能解析, 守田 匡伸; 南嶋 洋司; 井田 智章; 松永 哲郎; 笠松 真吾; 西村 明; 藤井 重元; 市瀬 史; 赤池 孝章, Feb. 2017, 72, 1, 98, 98
• 膵癌細胞は癌間質のグリコサミノグリカンをエネルギー源にしている, 岸本 翔太郎; 早川 典代; 末松 誠; 南嶋 洋司, Oct. 2016, 日本癌学会総会記事, 75回, IS6, 1
• 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 Cori回路制御機構の解明, 壽原 朋宏; 菱木 貴子; 笠原 正貴; 早川 典代; 小柳津 智子; 中西 豪; 久保 亜紀子; 末松 誠; 南嶋 洋司; 森崎 浩, Jan. 2016, 23, Suppl., 428, 428
• シングルセル生物学 ヒト大腸がん肝転移病巣のin vivo細胞周期依存的エネルギー代謝を質量分析イメージングで可視化する, 久保 亜紀子[弓場]; 鮑 彦; 向井 邦晃; 菱木 貴子; 大村 光代; 南嶋 洋司; 末松 誠, Dec. 2015, 88回・38回, [1W13, 3]
• 低酸素応答によるCori回路の制御機構の解明 肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発, 寿原 朋宏; 菱木 貴子; 笠原 正貴; 早川 典代; 小柳津 智子; 中西 豪; 久保 亜紀子; 森崎 浩; Kaelin Jr. William G.; 末松 誠; 南嶋 洋司, Dec. 2015, 88回・38回, [4T特, 06(3P1182)]
• 腎性貧血を標的とした新しい創薬に向けて 成人肝細胞のエリスロポイエチン産生能力再活性化と、その腎性貧血治療への応用 PHD-HIF依存的低酸素応答をターゲットとした新しい治療法の開発, 南嶋 洋司, May 2013, 46, Suppl.1, 367, 367
• 低酸素応答が制御する多彩な生命現象 生理機能の解明から疾患に迫る 低酸素応答によるin vivoでの細胞内エネルギー代謝の制御, 南嶋 洋司; 末松 誠, Dec. 2012, 85回, 1S12, 8
• in vivo低酸素応答の功罪, 南嶋 洋司; Moslehi Javid; Kaelin Jr. William G.; 末松 誠, Sep. 2011, 84回, 2S4p, 3
• 低酸素応答と成体肝細胞におけるerythropoietin産生の再活性化 HIFプロリン水酸化酵素をターゲットとした腎性貧血治療の可能性(Postnatal Reactivation of Hepatic Erythropoietin Production After PHD Inactivation: Impact on the treatment of anemia due to chronic renal failure), 南嶋 洋司; 末松 誠; Kaelin Jr. William G., Dec. 2010, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4T7, 10
• 血清枯渇が放射線照射後のmitotic cell deathに与える影響について 中心体過剰複製の関与, 庄野 正規; 佐藤 典宏; 水元 一博; 南嶋 洋司; 永井 英司; 田中 雅夫, Mar. 2001, 102, 臨増, 438, 438
• 多臓器不全に陥り腎摘を余儀なくされた死体腎移植の一例, 平野 達也; 南嶋 洋司; 中房 祐司; 斉藤 省一郎, Aug. 1998, 75, 8, 1826, 1826
• 多臓器不全に陥ったHBsAg陽性レシピエントへの死体腎移植の1例, 平野 達也; 南嶋 洋司; 中房 祐司; 斉藤 省一郎, Jun. 1998, 33, 3, 249, 249
• 特異な形態の結腸癌として診断された胆嚢原発転移性結腸癌の1手術例, 南嶋 洋司, May 1998, 51, 5, 356, 356
• Colo-rectal endometriosisの2症例, 南嶋 洋司, Oct. 1997, 58, 増刊, 354, 354
• 移植後17日目に急激な急性拒絶反応を呈した生体腎移植の1例, 南嶋 洋司, Aug. 1997, 74, 8, 2054, 2055
• 移植後17日目に急激な急性拒絶反応を呈した生体腎移植の1例, 南嶋 洋司, Jun. 1997, 32, 3, 222, 223
• 限局性胆管拡張で発見された早期肝内胆管癌の一治癒切除例, 南嶋 洋司, Mar. 1997, 74, 3, 679, 679
• CMV抗体陽性ドナーから抗体陰性ドナーへ生体腎移植を行った2例, 南嶋 洋司, Oct. 1996, 31, 5, 467, 467
• S状結腸憩室膀胱瘻の一例, 南嶋 洋司, Jul. 1995, 48, 6, 555, 555
• アクチン結合蛋白フィラミンBは受容体を細胞表面に維持することで内皮スフィンゴシン1リン酸受容体1の機能を制御している(Actin-binding protein Filamin B regulates endothelial sphingosine 1-phosphate receptor 1 functions by keeping the receptor on cell-surface), 大日方 英; Zhao Xian; 清塚 啓介; 小西 昭充; 南嶋 洋司, Oct. 2023, 日本生化学会大会プログラム・講演要旨集, 96回, [1P, 051]
• Metabolic alteration of branched-chain amino acids in the process of cellular senescence, 大日方英; 荒牧佑磨; 入江和樹; 南嶋洋司; 小西昭充, 2023, 質量分析総合討論会講演要旨集, 71st
• 低酸素応答の分子メカニズム-HIF-PH阻害剤の臨床応用-, 南嶋洋司, 2023, 53, 4, 47, 47
• テロメア短縮系を用いた効率的な複製老化系の樹立および分岐鎖アミノ酸代謝の細胞老化における役割の解析, 入江和樹; 荒牧佑磨; 土田愛子; 大日方英; 和泉孝志; 南嶋洋司; 南嶋洋司; 小西昭充, 2023, 96th, [1P, 388]
• HIFを介した低酸素応答の分子メカニズム, 南嶋洋司, 2022, 46th
• Proteomic analysis in senescent cells induced by telomere shortening, 土田愛子; 入江和樹; 荒牧佑磨; 南嶋洋司; 小西昭充, 2022, 日本分子生物学会年会プログラム・要旨集(Web), 45th
• 分岐鎖アミノ酸代謝の変調と細胞・個体老化, 小西昭充; 荒牧佑磨; 大日方英; 南嶋洋司, 2022, 8th
• Characterization of recombinant murine GDE4 and GDE7, enzymes producing lysophosphatidic acid and/or cyclic phosphatidic acid, Binderiya Tserendavga; Noriyasu Ohshima; Chiaki Fujita; Koji Yuzawa; Mari Ohshima; Noriyuki Yanaka; Yoji Andrew Minamishima; Takashi Izumi, Dec. 2021, Journal of biochemistry, 170, 6, 713, 727

  DOI
• Modulation of cellular senescence by branched-chain amino acid metabolism, 小西昭充; 荒牧佑磨; 大日方英; 本田真也; 和泉孝志; 清水重臣; 南嶋洋司, 2021, 日本分子生物学会年会プログラム・要旨集(Web), 44th
• LTBP2 is a novel marker in hepatocellular carcinoma, ERKHEM-OCHIR Bilguun; CHIVARINA Barbara; 横堀武彦; TURTOI Evgenia; OBINATA Hideru; NAVCHAA Gombodorj; NAVCHAA Gombodorj; MINAMISHIMA Yoji Andrew; MATSUZAKI Toshiyuki; 佐伯浩司; NISHIYAMA Masahiko; 調憲; TURTOI Andrei, 2020, 日本癌学会学術総会抄録集(Web), 79th
• MC3T3-E1における,脂質オートクライン刺激とエストラジオール刺激のクロストーク機構の解析, 鈴木啓; 大嶋紀安; 小西昭充; 立井一明; 佐藤精一; 和泉孝志; 南嶋洋司, 2020, 43rd
• Targeting hypoxic response machinery for the treatment of critical diseases~Clinical application of PHD inhibitors~, MINAMISHIMA Yoji Andrew, 2019, 日本薬理学会年会要旨集(Web), 92nd
• 骨芽細胞様細胞MC3T3-E1の細胞内外の脂質メディエーターがアクチン細胞骨格変化を介して骨形成を制御する, 鈴木啓; 大嶋紀安; 立井一明; 佐藤精一; 南嶋洋司; 和泉孝志; 小西昭充, 2019, 42nd
• 早期細胞老化におけるアミノ酸代謝の変調, 荒牧佑磨; 小西昭充; 南嶋洋司, 2019, 42nd
• 低酸素応答メカニズムを標的とした各種疾患治療法の開発, 南嶋洋司, 2019, 153, Supplement
• 老化・がん化耐性齧歯類ハダカデバネズミの代謝制御と疾患との関わり, 岡香織; 大岩祐基; 河村佳見; 杉浦悠毅; 南嶋洋司; 末松誠; 上原ひかる; 松田史生; 和氣正樹; 武田憲彦; 城戸康年; 稲岡健; 北潔; 三浦恭子, 2018, 41st
• 活性パースルフィドによるミトコンドリア膜電位形成機構の解明, 松永哲郎; 守田匡伸; 南嶋洋司; 西村明; 井田智章; 藤井重元; 本橋ほづみ; 赤池孝章, 2018, 71st
• シン・メタボリズム〜代謝が関わる多彩な生命現象〜 老化・がん化耐性齧歯類ハダカデバネズミのエネルギー代謝を制御する分子機構の解析, 岡 香織; 大岩 祐基; 河村 佳見; 杉浦 悠毅; 南嶋 洋司; 末松 誠; 和氣 正樹; 武田 憲彦; 城戸 康年; 稲岡 健ダニエル; 北 潔; 三浦 恭子, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [2PW05, 4]
• 硫化水素代謝酵素Sqrdlの生体における機能解析, 守田匡伸; 南嶋洋司; 井田智章; 松永哲郎; 笠松真吾; 西村明; 藤井重元; 市瀬史; 赤池孝章, 2017, 17th
• 老化・がん化耐性齧歯類ハダカデバネズミの代謝制御メカニズム, 岡香織; 大岩祐基; 杉浦悠毅; 南嶋洋司; 和氣正樹; 武田憲彦; 三浦恭子, 2016, 39th
• 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発, 小柳津(寅丸)智子; 小柳津(寅丸)智子; 壽原朋宏; 壽原朋宏; 早川典代; 早川典代; 中村貴; 南嶋しづか; 山口京二; 菱木貴子; 菱木貴子; 森崎浩; 末松誠; 南嶋洋司; 南嶋洋司; 南嶋洋司, 2016, 39th
• 低酸素応答とミトコンドリアストレス, 南嶋洋司, 2015, 15th
• HIFプロリン水酸化酵素PHD3はピルビン酸脱水素酵素PDH-E1βと結合して,細胞内のエネルギー代謝を制御する, 中山恒; 南嶋洋司; 南嶋洋司, 2014, 37th
• ヒト大腸がん細胞のin vitro同調培養およびin vivoにおける細胞周期依存的エネルギー代謝, 久保亜紀子; 久保亜紀子; BAO Y.; 向井邦晃; 菱木貴子; 菱木貴子; 大村光代; 南嶋洋司; 南嶋洋司; 末松誠; 末松誠, 2013, 61st
• 低酸素応答や細胞周期と細胞内エネルギー代謝制御, 南嶋洋司; 南嶋洋司; 鮑彦; 向井邦晃; 菱木貴子; 菱木貴子; 久保亜紀子; 久保亜紀子; 大村光代; 早川典代; 早川典代; 佐谷秀行; 末松誠; 末松誠, 2013, 1st
• 低酸素応答によるin vivoエネルギー代謝の制御, 南嶋洋司; 南嶋洋司; 笠原正貴; 笠原正貴; 早川典代; 早川典代; 寿原明宏; 寿原明宏; 末松誠; 末松誠, 2013, 36th
• Effect of acute or chronic hypoxic response in cardiomyocytes, MINAMISHIMA Yoji Andrew; MINAMISHIMA Yoji Andrew; MINAMISHIMA Yoji Andrew; MOSLEHI Javid; KAELIN William G., Jr.; SUEMATSU Makoto; SUEMATSU Makoto, 2011, 日本分子生物学会年会プログラム・要旨集(Web), 34th
• Postnatal Reactivation of Hepatic Erythropoietin Production After PHD Inactivation~Impact on the treatment of anemia due to chronic renal failure~, MINAMISHIMA Yoji Andrew; SUEMATSU Makoto; KAELIN William G., Jr., 2010, 生化学
• Detrimental effect of chronic HIF activation in vivo-Severe cardiomyopathy and hepatic steatosis-, MINAMISHIMA Yoji-Andrew; MOSLEHI Javid; PADERA Robert F.; BRONSON Roderick T.; KAELIN William G., Jr., 2009, 日本分子生物学会年会講演要旨集, 32nd, Vol.4
• Trials of preoperative portal embulic therapy for extended hepatectomy cases., 上田祐滋; 空閑啓高; 児嶋一司; 古川貢之; 西川卓志; 山田浩巳; 林透; 南嶋洋司; 河野通孝, 1998, 宮崎県医師会医学会誌, 21, 2
• マウスSkp1 cDNA及びgenomic DNAのクローニング, 南嶋洋司; 畠山鎮次; 豊野孝; 北川雅敏; 中山啓子; 中山敬一, 1998, 21st
• Treatment outcome of the small hepatoma in this hospital. Examination on usefulness and significance of the liver resection., 上田祐滋; 空閑啓高; 児嶋一司; 佐藤典宏; 南嶋洋司; 宮永修; 三原謙郎; 山田浩巳; 林透, 1997, 宮崎県医師会医学会誌, 21, 1
• Regulation of metabolism by the hypoxic response as a therapeutic target for various diseases, Minamishima Yoji Andrew, 2023, Proceedings for annual meeting of the japanese pharmacological society, 97, 1-B-S08-3

  DOI
• 分子状酸素による遺伝子発現調節から紐解く疾患生物学 肥満に伴う腎障害における腎虚血とPHD2の役割, 脇野 修; 二木 功治; 徳山 博文; 内藤 真紀子; 南嶋 洋司; 伊藤 裕, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [3PW08, 4]

Books etc

• 全人力・科学力・透析力・for the people 透析医学, Contributor, Jun. 2014, 5, 359-363, Textbook, ISBN: 9784753226795
• 見つける、量る、可視化する！質量分析実験ガイド, Contributor, Mar. 2013, General book, ISBN: 9784758101868
• 透析療法ネクストXXVII〜腎性貧血治療薬HIF-PH阻害薬への期待と課題:保存期から透析期まで〜, Contributor, Oct. 2021, 145p, ISBN: 9784865174397
• Lippincott Illustrated Reviews: Biochemistry, Edition 8, Joint translation, Yasuki Ishizaki; Keii Maruyama; Michiru Nishita; Yasuhiro Minami; Yoji Andrew Minamishima; Hideyuki Yamamoto; Akinori Yoda, Capter I-V, IIIV, Wolters Kluwer, Nov. 2023, 758, Textbook, ISBN: 9784621308523

Presentations

• [1P-0057] 早期細胞老化におけるアミノ酸代謝の変調, 荒牧佑磨; 小西昭充; 南嶋洋司, 第42回日本分子生物学会, 03 Dec. 2019, Japanese
• BRCA1 complex regulates cell cycle-dependent DNA damage response at telomeres to maintain chromosome integrity, 小西昭充; 南嶋洋司, 第78回日本癌学会学術総会, 28 Sep. 2019, Japanese, Domestic conference
• 様々な疾患の治療標的としての低酸素応答分子機構, 南嶋洋司, 第7回低酸素研究会, 27 Jul. 2019, 27 Jul. 2019, 27 Jul. 2019, Japanese, Domestic conference
• Targeting hypoxic response machinery for the treatment of critical diseases ~ Clinical application of PHD inhibitors ~, Yoji Andrew Minamishima, The 92nd Annual Meeting of the Japanese Pharmacological Society, 15 Mar. 2019, Japanese, Osaka International Convention Center, Domestic conference
• Targeting hypoxic response for the treatment of diseases, Yoji Andrew Minamishima, Tohoku Academy of Erythropoietin 2018, 16 Oct. 2018, Japanese, Sendai, Miyagi, Japan, Domestic conference
• Functional analysis of hydrogen sulfide detoxification enzyme, sulfide-quinone oxidoreductase, NISHIMURA Akira; MORITA Masanobu; MINAMISHIMA Youji; IDA Tomoaki; MATSUNAGA Tetsuro; FUJII Shigemoto; MOTOHASHI Hozumi; AKAIKE Takaaki, Annual Meeting of the Japanese Society of Toxicology, 10 Aug. 2018, Japanese
• Targeting hypoxic response for the treatment of diseases, Yoji Andrew Minamishima, Hypoxia Research Meeting 2018, 19 Jul. 2018, English, The University of Tokyo, Domestic conference
• 低酸素環境下で酵素活性が低下するプロリン水酸化酵素PHDを標的とした、腎性貧血や乳酸アシドーシスなど の様々な疾患の治療法の開発, 南嶋洋司, ComBio2017（2017年度生命科学系学会合同年次大会/第40回分子生物学会年会/第90回日本生化学会大会）, 08 Dec. 2017, Japanese, Domestic conference
• 心肺蘇生時に100％酸素吸入は必要か？ Effect of ventilation with high concentration oxygen during cardiopulmonary resuscitation on return of spontaneous circulation., 南嶋しづか; 井上敬; 伊原奈帆; 五十嵐達; 南嶋洋司; 森﨑浩, 第5回低酸素研究会, 29 Jul. 2017, Japanese, Domestic conference
• 腎性貧血治療薬として臨床治験中のPHD阻害剤の、乳酸アシドーシス特効薬へのドラッグ・リポジショニング, 小柳津-寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 久保亜紀子; 山口京二; 菱木貴子; 森崎浩; 末松誠; 南嶋洋司, 第5回低酸素研究会, 29 Jul. 2017, Japanese, Domestic conference
• 低酸素応答による細胞内エネルギー代謝制御機構, 小柳津-寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 久保亜紀子; 山口京二; 菱木貴子; 森﨑浩; 末松誠; 南嶋洋司, 第17回日本高気圧環境・潜水医学会 関東地方会, 10 Jun. 2017, Japanese, Domestic conference
• 低酸素応答メカニズムを標的としたメトホルミン関連乳酸アシドーシス (MALA)の新規治療法の開発, 小柳津-寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 久保亜紀子; 山口京二; 菱木貴子; 森﨑浩; 末松誠; 南嶋洋司, 第60回日本糖尿病学会/第4回肝臓と糖尿病・代謝研究会, 20 May 2017, Japanese, Domestic conference
• 低酸素応答を標的とした乳酸アシドーシス治療法の開発, 小柳津-寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 久保亜紀子; 山口京二; 菱木貴子; 森崎浩; 末松誠; 南嶋洋司, 平成29年度日本生化学会九州支部例会宮崎大会, 14 May 2017, Japanese, Domestic conference
• Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis, Oyaizu-Toramaru T; Suhara T; Hayakawa N; Nakamura T; Minamishima S; Kubo A; Yamaguchi K; Hishiki T; Morisaki H; Suematsu M; Minamishima YA, The 90th Annual Meeting of the Japanese Pharmacological Society, 16 Mar. 2017, English, Nagasaki, Japan, Domestic conference
• Targeting oxygen sensor PHD for the treatment of metformin-associated lactic acidosis (MALA), Oyaizu-Toramaru T; Suhara T; Hayakawa N; Nakamura T; Minamishima S; Kubo A; Yamaguchi K; Hishiki T; Morisaki H; Suematsu M; Minamishima YA, Keystone Symposia “Adaptations to Hypoxia in Physiology and Disease (X4)”, 07 Mar. 2017, English, International conference
• 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発 ~ Cori 回路制御機構の解明~, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 末松誠; 南嶋洋司; 森崎浩, 第43回 日本集中治療医学会学術集会, 12 Feb. 2017, Japanese, Domestic conference
• 低酸素センサーPHDを標的としたメトホルミン誘発乳酸アシドーシス(MALA)治療法の開発, 小柳津-寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 山口京二; 菱木貴子; 森崎浩; 末松誠; 南嶋洋司, 第39回日本分子生物学会年会, 30 Nov. 2016, Japanese, Domestic conference
• 膵癌細胞は間質に豊富に存在するグリコサミノグリカンを栄養源にして いる, 岸本翔太郎; 早川典代; 末松誠; 南嶋洋司, 第14回がんとハイポキシア研究会, 05 Nov. 2016, Japanese, Domestic conference
• 膵癌細胞は癌間質のグリコサミノグリカンをエネルギー源にしている, 岸本翔太郎; 早川典代; 末松誠; 南嶋洋司, 第75回日本癌学会学術総会, 07 Oct. 2016, English, Domestic conference
• Prolyl hydroxylase (PHD) as a therapeutic target for metformin-associated lactic acidosis, 寅丸智子; 壽原朋宏; 早川典代; 中村貴; 南嶋しづか; 菱木貴子; 森崎浩; 末松誠; 南嶋洋司, 第4回低酸素研究会, 23 Jul. 2016, Japanese, Domestic conference
• 低酸素・低栄養環境下で増殖する膵管癌 (PDAC)は、間質のグリコサミノグリカン (GAG)を栄養源にしている, 岸本翔太郎; 早川典代; 末松誠; 南嶋洋司, 第4回低酸素研究会, 23 Jul. 2016, Japanese, Domestic conference
• 膵癌細胞は間質のグリコサミノグリカンを栄養源にしている, 岸本翔太郎; 早川典代; 末松誠; 南嶋洋司, 第4回がんと代謝研究会, 08 Jul. 2016, Japanese, Domestic conference
• Glycosaminoglycan as an energy source for pancreatic cancer cells., Shotaro Kishimoto; Noriyo Hayakawa; Makoto Suematsu; Yoji Andrew Minamishima, The 10th AACR-JCA Joint Conference, 18 Feb. 2016, English, Hyatt Regency Maui, Maui, Hawaii, International conference
• 致死的乳酸アシドーシスに対する、低酸素センサーPHDを標的とした新しい治療法の開発, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 森崎浩; Kaelin WG J; 末松誠; 南嶋洋司, 新学術領域 酸素生物学・ダイイングコード合同若手会議, 27 Jan. 2016, Japanese, Domestic conference
• 低酸素応答によるCori回路の制御機構の解明〜肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発〜, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 森崎浩; Kaelin WG J; 末松誠; 南嶋洋司, BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）, 04 Dec. 2015, Japanese, Domestic conference
• 低酸素センサーPHD2を阻害するとCori回路の肝内経路の活性化を介して致死的乳酸アシドーシスの生存率が改善される, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 森崎浩; Kaelin WG J; 末松誠; 南嶋洋司, 第27回高遠シンポジウム, 26 Aug. 2015, Japanese, Domestic conference
• Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle, Suhara T; Hishiki T; Kasahara M; Hayakawa N; Oyaizu T; Nakanishi T; Kubo A; Morisaki H; Kaelin WG Jr; Suematsu M; Minamishima YA, 第3回低酸素研究会, 25 Jul. 2015, Japanese, Domestic conference
• 低酸素応答とミトコンドリアストレス, 南嶋洋司, 第15回日本蛋白質科学会年会, 25 Jun. 2015, Japanese, Domestic conference
• 肝臓における低酸素応答はCori回路の活性化を介して血中乳酸レベルを制御している, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 森崎浩; William G. Kaelin J; 末松誠; 南嶋洋司, 第13回がんとハイポキシア研究会, 05 Jun. 2015, Japanese, Domestic conference
• Inactivating HIF-prolyl hydroxylase PHD2 in liver improves survival after lactic acidosis by activating Cori cycle, Suhara T; Hishiki T; Kasahara M; Hayakawa N; Oyaizu T; Nakanishi T; Kubo A; Morisaki H; Suematsu M; Minamishima YA, Keystone Symposia “Hypoxia: From Basic Mechanisms to Therapeutics (E3)”, 14 May 2015, English, International conference
• 低酸素応答による乳酸代謝制御機構, 壽原朋宏; 笠原正貴; 菱木貴子; 早川典代; 南嶋洋司; 末松誠, 第12回がんとハイポキシア研究会, 21 Nov. 2014, Japanese, Domestic conference
• “Regulation of cellular metabolism in vivo by hypoxic response”, Yoji Andrew Minamishima, 熊本大学博士課程教育リーディングプログラム (HIGO program), 27 Jun. 2014, English
• Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro, Bao Y; Mukai K; Hishiki T; Kubo A; Ohmura M; Sugiura Y; Matsuura T; Nagahata Y; Hayakawa N; Yamamoto T; Fukuda R; Saya H; Suematsu M; Minamishima YA, Keystone Symposia "Tumor Metabolism (X6)", 18 Mar. 2014, English, International conference
• 低酸素応答によるin vivoレベルでの代謝制御機構, 南嶋洋司, 第1回お茶の水サイエンス倶楽部, 03 Mar. 2014, Japanese, Domestic conference
• PHD2-HIF dependent hypoxic response regulates Cori cycle, Kasahara M; Suhara T; Hayakawa N; Suematsu M; Minamishima YA, Keystone Symposia “Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (A1)”, 09 Jan. 2014, English, International conference
• 低酸素応答とin vivo糖・乳酸代謝, 南嶋洋司; 笠原正貴; 壽原朋宏; 早川典代; 末松誠, 第11回がんとハイポキシア研究会, 14 Dec. 2013, Japanese, Domestic conference
• Regulation of energy metabolism by hypoxic response in vivo, Yoji Andrew Minamishima; Masataka Kasahara; Noriyo Hayakawa; Tomohiro Suhara; Makoto Suematsu, The 36th Annual Meeting of the Molecular Biology Society of Japan, 03 Dec. 2013, Japanese, Kobe Port Island, Kobe, Hyogo, Japan, Domestic conference
• 低酸素応答や細胞周期と細胞内エネルギー代謝制御, 南嶋洋司, 第1回がんと代謝研究会, 31 Oct. 2013, Japanese, Domestic conference
• ヒト大腸がん細胞のin vitro同調培養およびin vivoにおける細胞周期依存的エネルギー代謝, 久保亜紀子; 鮑彦; 向井邦晃; 菱木貴子; 大村光代; 南嶋洋司; 末松誠, 第61回質量分析総合討論会, 11 Sep. 2013, Japanese, Domestic conference
• 低酸素応答によるエネルギー代謝制御機構〜臓器間のクロストーク〜, 南嶋洋司, 第1回低酸素研究会, 06 Jul. 2013, Japanese, Domestic conference
• 成人肝細胞のエリスロポイエチン産生能力再活性化と、その腎性貧血治療への応用～PHD-HIF依存的低酸素応答をターゲットとした新しい治療法の開発～, 南嶋洋司, 第58回日本透析医学会学術集会, 23 Jun. 2013, Japanese, Domestic conference
• “In vivo Gas Biology ~ Cellular response against hypoxia or hydrogen sulfide (H2S) ~”, 南嶋洋司, 名古屋大学大学院医学系研究科平成25年度基盤医学特論, 16 May 2013, Japanese
• In vivo Gas Biology ~ Cellular response against hypoxia or hydrogen sulfide (H2S) ~, MINAMISHIMA; Yoji andrew, Special Seminar Tokuron 2013, 16 May 2013, Japanese, Nagoya, Aichi, Japan, Domestic conference
• Hypoxic response and cellular metabolism, Yoji Andrew Minamishima, Cancer Area Meeting, Graduate School of Medicine, Kyoto University, 20 Dec. 2012, English, Kyoto city, Kyoto, Japan, Domestic conference
• Symposium: Hypoxic Response in the Multiple Cellular Events –understanding the molecular mechanisms in physiological and pathophysiological conditions-, MINAMISHIMA; Yoji andrew, The 85th Annual meeting of The Japanese Biochemical Society, 14 Dec. 2012, Japanese, Fukuoka International Congress Center / Marine Messe Fukuoka, Domestic conference
• In vivo Gas Biology ~Response against hypoxia or hydrogen sulfide and cellular metabolism~, MINAMISHIMA; Yoji andrew, Special Lecture at Graduate School of Miyazaki University, 19 Oct. 2012, Japanese, Miyazaki City, Miyazaki, Japan, Domestic conference
• In vivo Gas Biology 〜低酸素および硫化水素への生体応答が、細胞・個体に与える影響〜, 南嶋洋司, 第6回東北眼疾患病態研究会, 23 Jul. 2012, Japanese, Domestic conference
• PHD as a therapeutic target, Yoji Andrew Minamishima, The 33rd Naito Conference, 27 Jun. 2012, English, Chateraise Gateaux Kingdom Sapporo, International conference
• In vivo Gas Biology ~低酸素および硫化水素への生体応答が、細胞・個体に与える影響~, 南嶋洋司, 北海道大学大学院薬学研究院/日本薬学会北海道支部 特別講演会, Jun. 2012, Japanese, Domestic conference
• Effect of acute or chronic hypoxic response in cardiomyocytes, Minamishima YA; Moslehi J; Kaelin WG Jr; Suematsu M, The Molecular Biology Society of Japan 34th Annual Meeting, 14 Dec. 2011, Japanese, Yokohama, Japan, Domestic conference
• Acute HIF Prolyl Hydroxylase 2 Inactivation Confers Protection Against Myocardial Ischemic Reperfusion Injury, Bair SM; Minamishima YA; Liao R; Kaelin WG Jr; Moslehi J, AHA Scientific Session 2011, Core 5. Myocardium: Function and Failure. Session Title: Protection of Ischemic Myocardium, 12 Nov. 2011, English, International conference
• Hypoxic response and cellular metabolism, Yoji Andrew Minamishima, Biocenter Oulu Doctoral Programme Advanced Course, Cellular Signalling Networks – From molecular components to complex life processes, Autumn 2011, Nov. 2011, English, Oulu, Finland, Domestic conference
• In vivo Gas Biology ~Response against hypoxia or hydrogen sulfide and cellular metabolism~, MINAMISHIMA; Yoji andrew, 第一三共株式会社セミナー, Oct. 2011, Japanese, Domestic conference
• 低酸素に対する生体応答が細胞・個体に与える影響とその制御機構, 南嶋洋司, 第8回臨床・腫瘍外科セミナー, Sep. 2011, Japanese, Domestic conference
• Symposium "Frontiers of Hypoxia Biology” ~ from its physiological functions to diseases ~, Yoji Andrew; MINAMISHIMA, The 84th Annual Meeting of the Japanese Biochemical Society, Sep. 2011, Japanese, Kyoto, JAPAN, Domestic conference
• 低酸素応答が生体に与える影響〜その功罪について〜, 南嶋洋司, 第164回横浜市立大学医学会講演会, Jul. 2011, Japanese, Domestic conference
• 低酸素に対する生体反応が個体に及ぼす影響, 南嶋洋司, 第34回生命医科学科講演会, May 2011, Japanese, Domestic conference
• Beneficial or Detrimental Effect of Hypoxic Response in Cardiomyocytes, Minamishima YA; Moslehi J; Suematsu M; Kaelin WG Jr, The 36th Annual Meeting of the Japanese Society for Microcirculation, 11 Feb. 2011, Japanese, Nagoya City University Hospital, Domestic conference
• Beneficial or Detrimental Effect of Hypoxic Response in Cardiomyocytes, Minamishima YA; Moslehi J; Suematsu M; Kaelin WG Jr, The 8th Annual Meeting of the Japanese Association for Cancer and Hypoxia Research, 30 Jan. 2011, Japanese, Sapporo, Hokkaido, Domestic conference
• Postnatal Reactivation of Hepatic Erythropoietin (Epo) Production After PHD Inactivation, Minamishima YA; Suematsu M; Kaelin WG Jr, The 33rd Annual Meeting of Molecular Biology Society of Japan (BMB2010), 10 Dec. 2010, Japanese, Kobe Port Island, Domestic conference
• PHD/HIF pathway as a therapeutic target for ischemia repercussion injury, metabolic disorder and renal anemia, Yoji Andrew Minamishima, Kyowa Hakko Kirin Kidney Symposium, Oct. 2010, Japanese, Domestic conference
• Loss of PHD Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy, Moslehi J; Minamishima YA; Padera RF; Liao R; Kaelin WG Jr, 14th Annual Scientific Meeting Heart Failure Society of America, 12 Sep. 2010, English, International conference
• Beneficial or detrimental effect of hypoxia inducible factor (HIF) and its regulation in vivo, Yoji Andrew Minamishima, Keio University G-COE Symposium “Invitation to Gas Biology: Hypoxia-sensing mechanisms”, 05 Apr. 2010, 05 Apr. 2010, 05 Apr. 2010, English, Tokyo, Japan, Domestic conference
• Detrimental effect of chronic HIF activation in vivo, Yoji Andrew Minamishima, Keystone Symposia, Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response Pathways (B1), Jan. 2010, English, Keystone Resort, Keystone, Colorado, International conference
• Detrimental effect of chronic HIF activation in vivo ~ Severe cardiomyopathy and hepatic steatosis ~, Minamishima YA; Moslehi J; Padera RF; Bronson RT; Kaelin WG Jr, The Molecular Biology Society of Japan 32nd Annual Meeting, 12 Dec. 2009, Japanese, Domestic conference
• Regulation of Hypoxia-inducible factor in vivo by PHD prolyl-hydroxilases, Yoji Andrew Minamishima, Chiba Cancer Center Research Institute, 667th CCRI Seminar, 24 Feb. 2009, 24 Feb. 2009, Japanese, Chiba, Japan, Domestic conference
• Hydrogen Sulfide Improves Outcome after Cardiac Arrest and Cardiopulmonary Resuscitation in Mouse, Minamishima S; Yu JD; Bougaki M; Adrie C; Minamishima YA; Lefer DJ; Ichinose F, AHA Scientific Session 2008, Resuscitation Science Symposium, 09 Nov. 2008, English, International conference
• ASC (Apoptosis-associated Speck-like protein containing CARD) regulates apoptosis through the p53-Bax mitochondrial pathway, Otsuka T; Ryu H; Macip S; Minamishima YA; Aaronson SA; Lee SW, 94th AACR Annual Meeting: 2003, 11 Jul. 2003, English, International conference
• Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice, Yoji Andrew Minamishima, The Molecular Biology Society of Japan 24th Annual Meeting, Dec. 2001, Japanese, Yokohama, Japan, International conference
• 血清枯渇が放射線照射後のmitotic cell deathに与える影響について 中心体過剰複製の関与, 庄野正規; 佐藤典宏; 水元一博; 南嶋洋司; 永井英司; 田中雅夫, 第101回日本外科学会総会, 11 Apr. 2001, Japanese, Domestic conference
• 癌細胞の中心体過剰複製と放射線照射による分裂期細胞死: 新たな細胞死の機構, 水元一博; 佐藤典宏; 永井英司; 庄野正規; 南嶋洋司; 田中雅夫, 第101回日本外科学会総会, 11 Apr. 2001, Japanese, Domestic conference
• Molecular cloning of mouse Skp1 genome and cDNA, Yoji Andrew Minamishima, The Molecular Biology Society of Japan 21st Annual Meeting, 01 Dec. 1998, Japanese, Yokohama, Japan, Domestic conference
• 右坐骨神経より生じた多発性神経鞘腫の一例, 南嶋洋司; 佐藤裕; 和田好弘; 今泉暢登志; 吉田正彦, 第224回福岡外科集談会, 20 Dec. 1997, Japanese, Domestic conference
• 特異な形態の結腸癌として診断された胆嚢原発転移性結腸癌の一手術例, 南嶋洋司; 佐藤裕; 小川芳明; 和田好弘; 今泉暢登志; 吉田正彦, 第22回日本大腸肛門病学会九州地方会, 22 Nov. 1997, Japanese, Domestic conference
• Colo-rectal endometriosisの２症例, 南嶋洋司; 佐藤裕; 飛松正則; 清水周次; 大谷和広; 和田好弘; 今泉暢登志; 吉田正彦, 第59回日本臨床外科医学会, 13 Nov. 1997, Japanese, Domestic conference
• 多臓器不全に陥り腎摘を余儀なくされた死体腎移植の一例, 平野達也; 南嶋洋司; 中房祐司; 斉藤省一郎, 第17回九州腎移植臨床研究会, 28 Jun. 1997, Japanese, Domestic conference
• 多臓器不全に陥ったHBsAg陽性レシピエントへの死体腎移植の1例, 平野達也; 南嶋洋司; 中房祐司; 斉藤省一郎, 第31回日本腎移植臨床研究会, 28 Jun. 1997, Japanese, Domestic conference
• AFP産生膵癌（腺房細胞癌）の一手術例, 南嶋洋司; 飛松正則; 小川芳明; 和田好弘, 第34回九州外科学会, 17 May 1997, Japanese, Domestic conference
• 外傷性横隔膜ヘルニアの２症例, 上野隆幸; 上田祐滋; 南嶋洋司; 海江田衛; 小柳宏; 豊田清一, 第28回日本腹部救急医学会総会, 13 Mar. 1997, Japanese, Domestic conference
• 生体腎移植後17日目に発症した急激な急性拒絶反応の一症例, 南嶋洋司; 植木理夫; 平野達也; 中房祐司; 斉藤省一郎, 第30回日本腎移植臨床研究会, Feb. 1997, Japanese, Domestic conference
• 当院における小肝細胞癌（腫瘍径３ｃｍ以下）の治療成績, 上田祐滋; 児嶋一司; 南嶋洋司; 豊田清一; 西川卓志; 山田浩巳; 林透, 第18回九州肝臓外科研究会, 15 Jul. 1996, Japanese, Domestic conference
• 限局性胆管拡張で発見された早期肝内胆管癌の一治癒切除例, 南嶋洋司; 上田祐滋; 豊田清一, 第18回九州肝臓外科研究会, 15 Jul. 1996, Japanese, Domestic conference
• 生体腎移植後17日目に発症した急激な急性拒絶反応の一症例, 南嶋洋司; 植木理夫; 中房祐司; 斉藤省一郎, 九州腎移植研究会, 22 Jun. 1996, Japanese, Domestic conference
• 転移性肺癌手術症例の臨床的検討, 南嶋洋司; 上田祐滋; 豊田清一, 第33回九州外科学会, 10 May 1996, Japanese, Domestic conference
• CMV抗体陽性ドナーから抗体陰性レシピエントへ生体腎移植を行った２例, 南嶋洋司; 上田祐滋; 南嶋洋一; 豊田清一, 第29回日本腎移植臨床研究会, 03 Feb. 1996, Japanese, Domestic conference
• 原発性肺癌手術成績の検討-Ｔ因子、Ｎ因子、生存率からみたリンパ節郭清の意義-, 南嶋洋司; 上田祐滋; 豊田清一, 第8回宮崎肺癌研究会, 20 Jan. 1996, Japanese, Domestic conference
• 腎移植患者におけるCMV迅速診断体制の確立, 南嶋洋司; 上田祐滋; 南嶋洋一; 豊田清一, 南九州移植研究会, 09 Sep. 1995, Japanese, Domestic conference
• CAPD患者に生じた硬化性被覆性腹膜炎(SEP)の一手術例, 南嶋洋司; 上田祐滋; 豊田清一, 宮崎人工透析研究会, 15 Jul. 1995, Japanese, Domestic conference
• 原発性肝骨髄脂肪腫の一切除例, 南嶋洋司; 中野徹; 西方不二彦, 九州外科学会, 19 May 1995, Japanese, Domestic conference
• 腹腔鏡補助下内視鏡的polypectomyを施行したPeutz-Jeghers syndromeの一例, 南嶋洋司; 大畑佳裕; 志村英生; 田中雅夫, 九州消化器病学会, 11 Nov. 1994, Japanese, Domestic conference
• 急性骨髄性白血病化学療法中に発症した急性虫垂炎の一例, 南嶋洋司; 中村賢二郎; 一宮仁; 田中雅夫, 九州消化器病学会, 11 Nov. 1994, Japanese, Domestic conference
• Ｓ状結腸憩室膀胱瘻の一例, 南嶋洋司; 大畑佳裕; 壬生隆一; 田中雅夫, 日本大腸肛門病学会九州地方会, 05 Nov. 1994, Japanese, Domestic conference
• 高齢者における腎移植の経験, 西中秀和; 中房祐司; 南嶋洋司; 本山健太郎; 平野達也; 田中雅夫; 亀井隆史; 平方秀樹; 久保充明; 平野直史; 植木理夫; 斉藤省一郎; 奥田哲也; 藤見惺, 第14回九州腎移植臨床研究会, Jun. 1994, Japanese, Domestic conference
• 原発性脾血管肉腫の一切除例, 南嶋洋司; 佐藤裕; 一宮仁; 田中雅夫, 九州外科学会, 06 May 1994, Japanese, Domestic conference
• 乳腺悪性葉状腫瘍に浸潤性小葉癌を合併した一例, 南嶋洋司; 黒木祥司; 田中雅夫; 中垣充, 福岡外科集談会, Nov. 1993, Japanese, Domestic conference
• 低酸素応答と臓器間ネットワーク, 南嶋 洋司, 第106回日本消化器病学会/第4回消化器臓器間ネットワーク研究会, 14 Apr. 2021, Japanese, Domestic conference
• 低酸素応答の分子メカニズムと、その腎性貧血の治療への応用, 南嶋 洋司, 日本病院薬剤師会関東ブロック第50回学術大会, 31 Oct. 2020, Japanese, Domestic conference
• 血中スフィンゴシン1リン酸の産生および分解過程におけるキャリアタンパク質の役割, 清塚 啓介; Zhao Xian; 南嶋 洋司; 大日方 英, 日本生化学会大会プログラム・講演要旨集, Sep. 2020, Sep. 2020, Sep. 2020, Japanese
• 新しい腎性貧血治療薬としてのHIF-PHD阻害薬〜これを聞けば全てが分かります〜 HIF-PH阻害剤 低酸素応答が個体に与える影響, 南嶋 洋司, 日本腎臓学会誌, Jul. 2020, Jul. 2020, Jul. 2020, Japanese
• 骨芽細胞様細胞MC3T3-E1の細胞内外の脂質メディエーターがアクチン細胞骨格変化を介して骨形成を制御する, 鈴木啓; 大嶋紀安; 立井一明; 佐藤精一; 南嶋洋司; 和泉孝志; 小西昭充, 日本分子生物学会年会プログラム・要旨集(Web), 2019, 2019, 2019
• 老化・がん化耐性齧歯類ハダカデバネズミの代謝制御と疾患との関わり, 岡香織; 大岩祐基; 河村佳見; 杉浦悠毅; 南嶋洋司; 末松誠; 上原ひかる; 松田史生; 和氣正樹; 武田憲彦; 城戸康年; 稲岡健; 北潔; 三浦恭子, 日本分子生物学会年会プログラム・要旨集(Web), 2018, 2018, 2018, Japanese
• 低酸素環境下で酵素活性が低下するプロリン水酸化酵素PHDを標的とした,腎性貧血や乳酸アシドーシスなどの様々な疾患の治療法の開発, 南嶋洋司, 日本生化学会大会(Web), 2017, 2017, 2017, Japanese
• 肥満に伴う腎障害における腎虚血とPHD2の役割, 脇野修; 二木功治; 徳山博文; 内藤真紀子; 南嶋洋司; 伊藤裕, 日本生化学会大会(Web), 2017, 2017, 2017, Japanese
• 硫化水素代謝酵素Sqrdlの生体における機能解析, 守田匡伸; 南嶋洋司; 井田智章; 松永哲郎; 笠松真吾; 西村明; 藤井重元; 市瀬史; 赤池孝章, 日本NO学会学術集会プログラム抄録集, 2017, 2017, 2017, Japanese
• 肝臓における低酸素応答を標的とした新たな乳酸アシドーシス治療法の開発~Cori回路制御機構の解明~, 壽原朋宏; 菱木貴子; 笠原正貴; 早川典代; 小柳津智子; 中西豪; 久保亜紀子; 末松誠; 南嶋洋司; 森崎浩, 日本集中治療医学会学術集会(Web), 2016, 2016, 2016, Japanese
• 老化・がん化耐性齧歯類ハダカデバネズミの代謝制御メカニズム, 岡香織; 大岩祐基; 杉浦悠毅; 南嶋洋司; 和氣正樹; 武田憲彦; 三浦恭子, 日本分子生物学会年会プログラム・要旨集(Web), 2016, 2016, 2016
• 低酸素応答によるCori回路の制御機構の解明~肝臓における低酸素応答を標的とした新たな乳酸アシドーシスの治療法の開発~, 寿原朋宏; 寿原朋宏; 菱木貴子; 菱木貴子; 菱木貴子; 菱木貴子; 笠原正貴; 笠原正貴; 早川典代; 早川典代; 早川典代; 小柳津智子; 小柳津智子; 中西豪; 中西豪; 久保亜紀子; 久保亜紀子; 森崎浩; KAELIN William G., Jr; KAELIN William G., Jr; 末松誠; 末松誠; 南嶋洋司; 南嶋洋司, 日本生化学会大会(Web), 2015, 2015, 2015, Japanese
• ヒト大腸がん肝転移病巣のin vivo細胞周期依存的エネルギー代謝を質量分析イメージングで可視化する, 久保(弓場)亜紀子; 鮑彦; 向井邦晃; 菱木貴子; 大村光代; 大村光代; 南嶋洋司; 南嶋洋司; 末松誠; 末松誠, 日本生化学会大会(Web), 2015, 2015, 2015, Japanese
• HIFプロリン水酸化酵素PHD3はピルビン酸脱水素酵素PDH-E1βと結合して,細胞内のエネルギー代謝を制御する, 中山恒; 南嶋洋司; 南嶋洋司, 日本分子生物学会年会プログラム・要旨集(Web), 2014, 2014, 2014
• 成人肝細胞のエリスロポイエチン産生能力再活性化と,その腎性貧血治療への応用~PHD-HIF依存的低酸素応答をターゲットとした新しい治療法の開発~, 南嶋洋司, 日本透析医学会雑誌, 2013, 2013, 2013, Japanese
• 低酸素応答によるin vivoでの細胞内エネルギー代謝の制御, 南嶋洋司; 南嶋洋司; 末松誠; 末松誠, 日本生化学会大会(Web), 2012, 2012, 2012, Japanese
• in vivo低酸素応答の功罪, 南嶋洋司; 南嶋洋司; 南嶋洋司; MOSLEHI Javid; KAELIN William G., Jr.; 末松誠; 末松誠, 生化学, 2011, 2011, 2011, Japanese
• 多臓器不全に陥り腎摘を余儀なくされた死体腎移植の一例, 平野 達也; 南嶋 洋司; 中房 祐司; 斉藤 省一郎, 臨牀と研究, Aug. 1998, Aug. 1998, Aug. 1998, Japanese
• 多臓器不全に陥ったHBsAg陽性レシピエントへの死体腎移植の1例, 平野 達也; 南嶋 洋司; 中房 祐司; 斉藤 省一郎, 移植, Jun. 1998, Jun. 1998, Jun. 1998, Japanese
• 特異な形態の結腸癌として診断された胆嚢原発転移性結腸癌の1手術例, 南嶋 洋司, 日本大腸肛門病学会雑誌, May 1998, May 1998, May 1998, Japanese
• Colo-rectal endometriosisの2症例, 南嶋 洋司, 日本臨床外科医学会雑誌, Oct. 1997, Oct. 1997, Oct. 1997, Japanese
• 移植後17日目に急激な急性拒絶反応を呈した生体腎移植の1例, 南嶋 洋司, 臨牀と研究, Aug. 1997, Aug. 1997, Aug. 1997, Japanese
• 移植後17日目に急激な急性拒絶反応を呈した生体腎移植の1例, 南嶋 洋司, 移植, Jun. 1997, Jun. 1997, Jun. 1997, Japanese
• 限局性胆管拡張で発見された早期肝内胆管癌の一治癒切除例, 南嶋 洋司, 臨牀と研究, Mar. 1997, Mar. 1997, Mar. 1997, Japanese
• CMV抗体陽性ドナーから抗体陰性ドナーへ生体腎移植を行った2例, 南嶋 洋司, 移植, Oct. 1996, Oct. 1996, Oct. 1996, Japanese
• S状結腸憩室膀胱瘻の一例, 南嶋 洋司, 日本大腸肛門病学会雑誌, Jul. 1995, Jul. 1995, Jul. 1995, Japanese
• 敗血症に関する基礎研究-2 低酸素応答は敗血症の予後を改善させるか?, 壽原 朋宏; 伊原 奈帆; 南嶋 しづか; 寅丸 智子; 鈴木 悠太; 長田 大雅; 山田 高成; 南嶋 洋司; 森崎 浩, 日本集中治療医学会雑誌, Sep. 2020, Sep. 2020, Sep. 2020, Japanese
• LTBP2 is a Novel Marker in Hepatocellular Carcinoma, ERKHEM-OCHIR Bilguun; CHIVARINA Barbara; 横堀武彦; TURTOI Evgenia; OBINATA Hideru; NAVCHAA Gombodorj; NAVCHAA Gombodorj; MINAMISHIMA Yoji Andrew; MATSUZAKI Toshiyuki; 佐伯浩司; NISHIYAMA Masahiko; 調憲; TURTOI Andrei, 日本癌学会学術総会抄録集(Web), 2020, 2020, 2020
• Murine GDE4 and GDE7 produce lysophosphatidic acid and/or cyclic phosphatidic acid, Binderiya Tserendabga; Noriyasu Ohshima; Chiaki Fujita; Koji Yuzawa; Mari Ohshima; Noriyuki Yanaka; Yoji Andrew Minamishima; Takashi Izumi, The 94th Annual Meeting of the Japanese Biochemical Society, Nov. 2021, 03 Nov. 2021, 05 Nov. 2021, English
• 低酸素応答分子メカニズムの臨床応用, 南嶋 洋司, 第68回北関東医学会総会, 01 Oct. 2021, 30 Sep. 2021, 01 Oct. 2021, Japanese
• Modulation of cellular senescence by branched-chain amino acid metabolism, 小西昭充; 荒牧佑磨; 大日方英; 本田真也; 和泉孝志; 清水重臣; 南嶋洋司, 日本分子生物学会年会プログラム・要旨集(Web), Dec. 2021, 01 Dec. 2021, 03 Dec. 2021, Japanese
• 致死性乳酸アシドーシスを治療するための酸素センサーPHD(prolyl hydroxylase)の標的化(Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis), Oyaizu-Toramaru Tomoko; Suhara Tomohiro; Hayakawa Noriyo; Nakamura Takashi; Minamishima Shizuka; Kubo Akiko; Yamaguchi Kyoji; Hishiki Takako; Morisaki Hiroshi; Suematsu Makoto; Minamishima Yoji Andrew, Journal of pharmacological sciences, Mar. 2017, Mar. 2017, Mar. 2017, English
• Acute HIF prolyl hydroxylase 2 inactivation confers protection against myocardial ischemic reperfusion injury, Steven M. Bair; Yoji A. Minamishima; Ronglih Liao; William G. Kaelin; Javid Moslehi, Circulation, Nov. 2011, Nov. 2011, Nov. 2011, English
• Loss of PHD prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy, Javid Moslehi; Yoji Andy Minamishima; Robert Padera; Ronglih Liao; William G. Kaelin, Journal of cardiac failure, Aug. 2010, Aug. 2010, Aug. 2010, English
• Hydrogen sulfide improves outcome after cardiac arrest and cardiopulmonary resuscitation in mouse, Shizuka Minamishima; Jia De Yu; Masahiko Bougaki; Christophe Adrie; Yoji A. Minamishima; David J. Lefer; Fumito Ichinose, Circulation, Oct. 2008, Oct. 2008, Oct. 2008, English
• 細菌から哺乳類に至るまで保存されている硫化水素代謝酵素Sqrdlの遺伝子改変マウスを用いた機能解析, 守田匡伸; 南嶋洋司; 井田智章; 松永哲郎; 笠松真吾; 西村明; 藤井重元; 市瀬史; 赤池孝章, 日本細菌学雑誌(Web), 2017, 2017, 2017
• 低酸素応答の臨床応用〜HIF-PH阻害薬と腎性貧血などの疾患の治療〜, 南嶋洋司, 第53回九州人工透析研究会総会, 28 Nov. 2021, 28 Nov. 2021, 28 Nov. 2021, Japanese, Domestic conference
• MC3T3-E1における,脂質オートクライン刺激とエストラジオール刺激のクロストーク機構の解析, 鈴木啓; 大嶋紀安; 小西昭充; 立井一明; 佐藤精一; 和泉孝志; 南嶋洋司, 日本分子生物学会年会プログラム・要旨集(Web), Dec. 2020, 02 Dec. 2020, 04 Dec. 2020
• 低酸素応答は敗血症の予後を改善させるか?, 壽原朋宏; 伊原奈帆; 南嶋しづか; 寅丸智子; 鈴木悠太; 長田大雅; 山田高成; 南嶋洋司; 森崎浩, 日本集中治療医学会学術集会(Web), 2020, 2020, 2020, Japanese
• BRCA1 complex regulates cell cycle-dependent DNA damage repair at telomeres to maintain chromosome integrity, 小西昭充; 南嶋洋司, 日本癌学会学術総会抄録集(Web), 2019, 2019, 2019, English
• 早期細胞老化におけるアミノ酸代謝の変調, 荒牧佑磨; 小西昭充; 南嶋洋司, 日本分子生物学会年会プログラム・要旨集(Web), 2019, 2019, 2019
• 活性パースルフィドによるミトコンドリア膜電位形成機構の解明, 松永哲郎; 守田匡伸; 南嶋洋司; 西村明; 井田智章; 藤井重元; 本橋ほづみ; 赤池孝章, 日本酸化ストレス学会学術集会プログラム・抄録集, 2018, 2018, 2018
• シン・メタボリズム〜代謝が関わる多彩な生命現象〜 老化・がん化耐性齧歯類ハダカデバネズミのエネルギー代謝を制御する分子機構の解析, 岡 香織; 大岩 祐基; 河村 佳見; 杉浦 悠毅; 南嶋 洋司; 末松 誠; 和氣 正樹; 武田 憲彦; 城戸 康年; 稲岡 健ダニエル; 北 潔; 三浦 恭子, 生命科学系学会合同年次大会, Dec. 2017, Dec. 2017, Dec. 2017, Japanese
• 「低圧・低酸素から高圧・高酸素まで」臨床編 低酸素応答による細胞内エネルギー代謝制御機構, 南嶋 洋司, 日本高気圧環境・潜水医学会雑誌, Sep. 2017, Sep. 2017, Sep. 2017, Japanese
• 老化・がん化耐性齧歯類ハダカデバネズミのエネルギー代謝を制御する分子機構の解析, 岡香織; 大岩祐基; 河村佳見; 杉浦悠毅; 南嶋洋司; 末松誠; 和氣正樹; 武田憲彦; 城戸康年; 稲岡健ダニエル; 北潔; 三浦恭子, 日本生化学会大会(Web), 2017, 2017, 2017, Japanese
• Hypoxia and Disease 低酸素応答を標的とした各種疾患治療法の開発 致死的乳酸アシドーシスの新規治療法, 小柳津 智子; 寅丸; 壽原 朋宏; 早川 典代; 中村 貴; 南嶋 しづか; 山口 京二; 菱木 貴子; 森崎 浩; 末松 誠; 南嶋 洋司, 日本生化学会大会プログラム・講演要旨集, Sep. 2016, Sep. 2016, Sep. 2016, English
• PP543 癌細胞の中心体過剰複製と放射線照射による分裂期細胞死 :新たな細胞死の機構, 水元 一博; 佐藤 典宏; 永井 英司; 庄野 正規; 南島 洋司; 田中 雅夫, 日本外科学会雑誌, 10 Mar. 2001, 10 Mar. 2001, 10 Mar. 2001, Japanese
• PP858 血清枯渇が放射線照射後のmitotic cell deathに与える影響についてー中心体過剰複製の関与ー, 庄野 正規; 佐藤 典宏; 水元 一博; 南嶋 洋司; 永井 英司; 田中 雅夫, 日本外科学会雑誌, 10 Mar. 2001, 10 Mar. 2001, 10 Mar. 2001, Japanese
• Molecular cloning of mouse Skp1 cDNA and genomic DNA, MINAMISHIMA Yohji; HATAKEYAMA Shigetsugu; TOYONO Takashi; KITAGAWA Masatoshi; NAKAYAMA Keiko; NAKAYAMA Kei-ichi, 日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998, 01 Dec. 1998, 01 Dec. 1998, Japanese
• シンポジウム13：肺癌病理における腫瘍微小環境「肺癌微小環境での低酸素応答と腫瘍免疫」, 南嶋 洋司, 第63回日本肺癌学会学術集会, 03 Dec. 2022, 01 Dec. 2022, 03 Dec. 2022, Japanese, Domestic conference
• シンポジウム：細胞内シグナルの開始・継続・終焉に働く多様なタンパク質分解機構「酸素濃度依存的プロリン水酸化とユビキチン-プロテアソーム系蛋白分解による低酸素応答の制御」, 南嶋 洋司, 第95回日本生化学会, 11 Nov. 2022, 09 Nov. 2022, 11 Nov. 2022, Japanese, Domestic conference
• シンポジウム：HIFと鉄代謝「HIFを介した低酸素応答の分子メカニズム」, 南嶋 洋司, 第46回日本鉄バイオサイエンス学会学術集会, 02 Sep. 2022, 02 Sep. 2022, 03 Sep. 2022, Japanese, Domestic conference
• Actin-binding protein Filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1., Xian Zhao; Keisuke Kiyozuka; Akimitsu Konishi; Reika Kawabata-Iwakawa; Yoji Andrew Minamishima; Hideru Obinata, The Journal of biological chemistry, 21 May 2023, 21 May 2023, 21 May 2023, English

Industrial Property Rights

• Patent right, Drug For Preventing Or Treating Lactic Acidosis, Yoji Andrew Minamishima; Tomohiro Suhara; Tomoko Toramaru; Kyoji Yamaguchi, 16/091,373, 07 Apr. 2017, Keio University, Tokyo, Japan, US2019/0151315A1, 23 May 2019
• Patent right, JP2017014507, 07 Apr. 2017, WO2017-175859, 12 Oct. 2017, WO2017-175859, 12 Oct. 2017
• Patent right, JP2017014507, 07 Apr. 2017, ; , WO2017-175859, 12 Oct. 2017

Awards

• Nov. 2011
• May 2011, Publisher

  対象リソースIRI
• Young Investigator Outstanding Oral Presentation Award, The 90t Annual Meeting of the Japanese Pharmacological Society, Yoji Andrew Minamishima, Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis, The Japanese Pharmacological Society, Mar. 2017, Japan society
• Best Poster Presentation Award, Yoji Andrew Minamishima, "Detrimental effect of chronic HIF activation in vivo", Dana-Farber Cancer Institute 5th Annual Postdoc and Grad Student Retreat, http://on.fb.me/1JeSXwX, Aug. 2009, Others

Research Projects

• Maintenance of CML stem cells through regulation of C/EBPbeta transcription factor, Hirai Hideyo; MINAMISHIMA Yoji; MAEKAWA Taira; YOKOTA Asumi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kyoto University, 01 Apr. 2013, 31 Mar. 2016, Coinvestigator not use grants, In order to achieve complete cure of chronic myeloid leukemia (CML), eradication of CML stem cells (CML-SCs) is cruicial. In this study, we focused on hypoxic microenvironment and regulation of the transcription factor C/EBPbeta, which is activated by BCR-ABL and promotes differentiation and exhaustion of CML-SCs. Hypoxic condition in vitro reduced the expression of C/EBPbeta in CML cell lines, and cytokine treatment could not reverse this effect. In contrast, when the mice, which had been transplanted with BCA-ABL expressing bone marrow cells, were treated with cytokines, exhaustion of CML-SCs were promoted via upregulation of C/EBPbeta. These results suggest that cytokine treatment may eradicate CML-SCs by remodeling bone marrow microenvironment including hypoxia in addition to direct action on CML-SCs., 25461415

  対象リソースIRI
• Elucidation of activating Cori cycle caused by inhibition of PHD2 in liver, KASAHARA Masataka; MINAMISHIMA Yoji Andrew; AKIKO Kubo; TAKAKO Hishiki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Keio University, 01 Apr. 2012, 31 Mar. 2015, Coinvestigator, Prolyl hydroxylase 2 (PHD2) is an oxygen sensor that regulate the activity of the hypoxia inducible factors in an oxygen dependent manner. The purpose of this study was to examine whether inactivation of PHD2 in the liver played an important role for activating Cori cycle and decreasing lactate levels in circulation. Blood lactate levels after treadmill test or lactate tolerance test were significantly lower in PHD2-liver-specific knockout (PHD2-LKO) mice. The stable isotope labeled lactate incorporation assay revealed that livers of PHD2-LKO mice produced significantly greater amounts of glucose derived from the labeled lactate than controls, suggesting that the blockade of PHD2 in the liver helps improve lactic acidosis by activating gluconeogenesis from lactate., Competitive research funding, 24659154

  対象リソースIRI
• New concept for treatment of iscgemia/reperfusion injuries brought by metabolomics, MINAMISHIMA Yoji Andrew; KUBO Akiko; YACHIE Ayako; HISHIKI Takako, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Keio University, 01 Apr. 2011, 31 Mar. 2015, Principal investigator, Cells turn on hypoxic response under the environment where the available oxygen molecules are limited. Hypoxic response is mainly regulated by transcriptional factor HIF (hypoxia-inducible factor), which is also negatively regulated by “oxygen sensor” prolyl-hydroxylase PHDs. Among all PHDs, inactivation of PHD2 alone is sufficient to activate HIF pathway. Given that hypoxic response is designed for tissue protection under the hypoxic environment such as ischemic diseases, activation of HIF by PHD2-blocade should have beneficial role in ischemia/reperfusion model. Here we reported that inactivation of Phd2 in mice myocardial infarction model revealed smaller infarction size and better cardiac function by maintaining higher ATP with lower oxygen consumption. Our study shed light on new treatment for ischemia reperfusion injuries by targeting oxygen sensor PHD2., 23310136

  対象リソースIRI
• Hypoxic Response and Cellular Metabolism, Makoto Suematsu; Mayumi Kajimura; Yasuaki Kabe; Yoji Andrew Minamishima, Japan Science and Technology Agency, JST Basic Research Programs (Exploratory Research for Advanced Technology :ERATO), Keio University, 2010, 2014, Principal investigator, Competitive research funding

  対象リソースIRI
• Oxygen sensor as a target of type-2 DM treatment, MINAMISHIMA Yoji Andrew, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Keio University, 2011, 2013, Principal investigator, Hypoxic response is mainly regulated by VHL-PHD-HIF pathway. Systemically activating HIF in mice clearly shows blood sugar lowering effect and upregulated insulin sensitivity. Our result would highlight on a new concept of type-II diabetes treatment which target hypoxic response pathway., 23659175

  対象リソースIRI
• Hypoxic response as a new treatment of Post cardiac arrest syndrome, MINAMISHIMA Shizuka; MINAMISHIMA Shiszuka; AKIKO Kubo; TAKAKO Hishiki; MAKOTO Suematsu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Keio University, 01 Apr. 2012, 31 Mar. 2015, Coinvestigator, We demonstrated that inhaled Nitric oxide (NO) could improve outcome after successful cardiopulmonary resuscitation (CPR) in mice. It is increasingly recognized that NO production in hypoxia correlate with HIF (hypoxia inducible factor), a transcription factor which regulate hypoxic response. The present study tried to demonstrate whether systemically activating HIF in mice could improve the outcome after CPR. Although survival rate, neurological and cardiac function ware assessed after cardiac arrest and CPR, HIF activation did not work to improve outcome after CPR., Competitive research funding, 24659705

  対象リソースIRI
• Identification of the specific metabolic system for cellular senescence and tumorigenesis, Minamishima Yoji Andrew; Akiko Kubo; Takako Hishiki; Yuki Sugiura, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Keio University, 01 Apr. 2014, 31 Mar. 2017, Principal investigator, We have performed metabolome analysis on fresh, senescent, and immortalized stage in “cellular senescence to spontaneous immortalization model” using mouse embryonic fibroblasts (MEFs) 3T3 technique. Several senescent stage-specific and immortalization-specific metabolic pathways were determined, and tetracycline-inducible tunable senescence / immortalization cellular model were under development., 26670163

  対象リソースIRI
• Investigation of hypoxia adaptation and metabolic regulation in the cancer- and senescence-resistant rodent, the naked mole rat., Miura Kyoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Hokkaido University, 10 Jul. 2014, 31 Mar. 2019, Coinvestigator, In this study, by interspecies comparison between naked mole rats (NMRs) and mice, we identified the upregulated or downregulated metabolic pathways, possibly contributing to the senescence-resistance of the NMR. Next, we succeeded to generate NMR-iPS cells and revealed that NMR-iPS cells have tumor-resistance. Interestingly, NMR-fibroblasts failed to reprogram in a hypoxic condition. Thus, the response of the NMR cells to oxygen condition during the reprogramming process seems to be unique. Additionally, we identified the social context-dependent brown adipose tissues thermogenesis in the NMRs., 26111006

  対象リソースIRI
• Shizuka Minamishima, Yoji Andrew Minamishima, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma University, 01 Apr. 2020, 31 Mar. 2023, Coinvestigator, 20K09229

  対象リソースIRI
• Elucidation of the regulatory mechanism of metabolism in response to hypoxia by hydroxylation omics analysis, Minamishima Yoji Andrew, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kyushu University, Gunma University, 01 Apr. 2016, 31 Mar. 2021, Principal investigator, In our body, there are many oxygenase enzymes in the cells. Although their Km values for oxygen differ, the activity of these oxygenases decreases by hypoxia. In this study, we focused on hydroxylase, whose activity has been well studied by hypoxia, and aimed to quantify, evaluate, and understand the hypoxic response itself by quantifying the hydroxylation state in cells, i.e., "hydroxyome analysis". Through metabolome, proteome, and lipidome analysis using mass spectrometry, we were able to identify "hypoxia marker" molecules that enable us to objectively quantify and qualify the hypoxic response itself in cells., 16H04723

  対象リソースIRI
• Reactivation of erythropoietin production in adult liver and its application for treatment of renal anemia, Yoji Andrew Minamishima, The Kidney Foundation Japan, Grant-in-aid for young investigators (2010), 2011, 2012, Principal investigator, Competitive research funding

  対象リソースIRI
• PHD2-inactivation and new strategy for a treatment of Ischemia/Reperfusion Injury, Yoji Andrew Minamishima, The NOVARTIS Foundation Japan for the Promotion of Science, The 24th Novartis Research Grants 2010, 2011, 2012, Principal investigator, Competitive research funding

  対象リソースIRI
• メタボローム解析を駆使した、低酸素応答によるインスリン感受性の制御機構の解明, Yoji Andrew; MINAMISHIMA, Takeda Science Foundation, Medical Research Award, 2011, Principal investigator, Competitive research funding

  対象リソースIRI
• 01 Apr. 2021, 31 Mar. 2024, 21K07144

  対象リソースIRI
• Regulation of chronic inflammation of blood vessels by a bioactive lipid mediator, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Gunma University, 01 Apr. 2021, 31 Mar. 2024, 21K06832

  対象リソースIRI
• 01 Apr. 2024, 31 Mar. 2027, 24K10090

  対象リソースIRI

Educational Activities

Teaching Experience

• 2019
• 2019
• 2019
• 2011, 2016
• 2011, 2015
• 2011, 2015
• Medical Biochemistry, Keio University School of Medicine, 2011, 2015

Social Contribution

Social Contribution

• 群馬大学公開講座 世界脳週間2019, 16 Jun. 2019, 16 Jun. 2019

  対象リソースIRI
• 低酸素に対する応答反応と、その病気の治療への応用, 14 Dec. 2019, 14 Dec. 2019

  対象リソースIRI
• ぐんまちびっ子大学, 10 Aug. 2019, 13 Aug. 2019, gunmachibikkouniversity2019poster.jpg

  添付ファイルのURL対象リソースIRI
• キャリアトーク, 27 Jul. 2013, 27 Jul. 2013
• 低酸素の生物学, 15 Nov. 2012, 22 Nov. 2012
• 医師のキャリア・臨床医か研究医か～ノーベル賞受賞ラボでの研究～, 27 Sep. 2022

  対象リソースIRI